Best TWAS P = 1.69e-08 · Best GWAS P= 9.80e-09 conditioned to 1.00e+00
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Sox6 | alternative TSS | XM_039106343.2 | 0.02 | 1 | 0.01 | 1.3e-02 | 5.5 | 3.83e-08 | 0.03 | FALSE |
| Adipose | Plekha7 | gene expression | Plekha7 | 0.34 | 1041 | 0.06 | 8.0e-07 | 5.53 | 3.18e-08 | 0.44 | FALSE |
| Adipose | Sox6 | gene expression | Sox6 | 0.04 | 1 | 0.03 | 6.0e-04 | -5.5 | 3.85e-08 | 0.04 | FALSE |
| Adipose | Sox6 | isoform ratio | XM_039106343.2 | 0.02 | 881 | 0.01 | 1.2e-02 | 5.47 | 4.44e-08 | 0.29 | FALSE |
| Adipose | C1h11orf58 | mRNA stability | C1h11orf58 | 0.47 | 46 | 0.1 | 5.0e-11 | 5.46 | 4.73e-08 | 0.54 | FALSE |
| Adipose | Pik3c2a | mRNA stability | Pik3c2a | 0.08 | 1 | 0.05 | 1.4e-06 | 5.43 | 5.77e-08 | 0.34 | FALSE |
| Adipose | Sox6 | mRNA stability | Sox6 | 0.05 | 881 | 0.02 | 6.1e-03 | -5.46 | 4.73e-08 | 0.46 | FALSE |
| BLA | Plekha7 | alternative polyA | XM_063279483.1 | 0.09 | 1041 | 0.06 | 6.2e-04 | -5.5 | 3.84e-08 | 0.48 | FALSE |
| BLA | Plekha7 | alternative polyA | XM_063279498.1 | 0.06 | 1 | 0.04 | 6.0e-03 | 5.3 | 1.13e-07 | 0.04 | FALSE |
| BLA | Plekha7 | alternative polyA | XM_063279498.1 | 0.05 | 1 | 0.03 | 1.7e-02 | 5.3 | 1.13e-07 | 0.04 | FALSE |
| BLA | Plekha7 | alternative TSS | XM_063279498.1 | 0.06 | 1 | 0.01 | 5.0e-02 | -5.49 | 4.09e-08 | 0.04 | FALSE |
| BLA | Plekha7 | gene expression | Plekha7 | 0.12 | 1041 | 0.08 | 3.9e-05 | -5.49 | 3.99e-08 | 0.5 | FALSE |
| BLA | Plekha7 | isoform ratio | XM_039101147.2 | 0.07 | 1041 | 0.04 | 2.9e-03 | 5.54 | 3.07e-08 | 0.42 | FALSE |
| Brain | Plekha7 | alternative TSS | XM_063279498.1 | 0.03 | 1 | 0.01 | 3.5e-02 | -5.44 | 5.24e-08 | 0.03 | FALSE |
| Brain | Plekha7 | alternative TSS | XM_039101147.2 | 0.03 | 1041 | 0.02 | 7.5e-03 | 5.53 | 3.13e-08 | 0.39 | FALSE |
| Brain | Plekha7 | alternative TSS | XM_063279498.1 | 0.03 | 1 | 0.01 | 1.6e-02 | -5.49 | 3.94e-08 | 0.03 | FALSE |
| Brain | C1h11orf58 | gene expression | C1h11orf58 | 0.07 | 882 | 0.05 | 1.9e-05 | 5.48 | 4.36e-08 | 0.53 | FALSE |
| Brain | LOC120099912 | gene expression | LOC120099912 | 0.14 | 1 | 0.13 | 6.8e-12 | -5.49 | 3.94e-08 | 0.54 | FALSE |
| Brain | Plekha7 | gene expression | Plekha7 | 0.18 | 1 | 0.15 | 1.2e-13 | -5.44 | 5.27e-08 | 0.47 | FALSE |
| Brain | Rps13 | gene expression | Rps13 | 0.03 | 1055 | 0.03 | 1.6e-03 | -5.51 | 3.51e-08 | 0.42 | FALSE |
| Eye | Plekha7 | isoform ratio | XM_039101152.2 | 0.43 | 1041 | 0.05 | 6.9e-02 | 5.47 | 4.59e-08 | 0.21 | FALSE |
| IC | LOC120099912 | gene expression | LOC120099912 | 0.08 | 1037 | 0.04 | 6.5e-03 | -5.49 | 4.02e-08 | 0.32 | FALSE |
| IC | Plekha7 | gene expression | Plekha7 | 0.08 | 1041 | 0.02 | 4.0e-02 | -5.51 | 3.58e-08 | 0.32 | FALSE |
| LHb | Sox6 | alternative TSS | XM_063285275.1 | 0.21 | 1 | 0.11 | 1.7e-03 | -5.55 | 2.78e-08 | 0.06 | FALSE |
| Liver | Pik3c2a | gene expression | Pik3c2a | 0.02 | 1151 | 0.01 | 1.6e-02 | 5.55 | 2.80e-08 | 0.27 | FALSE |
| Liver | Rps13 | gene expression | Rps13 | 0.04 | 1055 | 0.02 | 4.3e-03 | -5.54 | 3.04e-08 | 0.42 | FALSE |
| Liver | Nucb2 | isoform ratio | NM_021663.2 | 0.04 | 1148 | 0.01 | 8.0e-03 | 5.54 | 3.11e-08 | 0.35 | FALSE |
| Liver | Nucb2 | isoform ratio | XM_006230095.5 | 0.03 | 1148 | 0.01 | 2.5e-02 | -5.54 | 3.04e-08 | 0.28 | FALSE |
| Liver | Nucb2 | intron excision ratio | chr1_180185261_180203629 | 0.03 | 12 | 0.01 | 2.4e-02 | -5.44 | 5.37e-08 | 0.34 | FALSE |
| Liver | Nucb2 | intron excision ratio | chr1_180190391_180203629 | 0.06 | 1 | 0.01 | 9.7e-03 | 5.45 | 5.17e-08 | 0.03 | FALSE |
| Liver | Sox6 | intron excision ratio | chr1_179377361_179444989 | 0.18 | 1 | 0.02 | 5.7e-03 | 5.5 | 3.85e-08 | 0.03 | FALSE |
| NAcc | Plekha7 | alternative TSS | XM_039101147.2 | 0.01 | 2 | 0.01 | 3.2e-03 | 5.64 | 1.69e-08 | 0.35 | TRUE |
| NAcc | C1h11orf58 | gene expression | C1h11orf58 | 0.05 | 882 | 0.04 | 3.8e-07 | 5.47 | 4.61e-08 | 0.53 | FALSE |
| NAcc | LOC120099912 | gene expression | LOC120099912 | 0.06 | 1037 | 0.06 | 1.0e-08 | -5.54 | 2.99e-08 | 0.51 | FALSE |
| NAcc | Nucb2 | gene expression | Nucb2 | 0.02 | 1148 | 0.01 | 3.8e-02 | 5.54 | 2.98e-08 | 0.37 | FALSE |
| NAcc | Pik3c2a | gene expression | Pik3c2a | 0.02 | 1 | 0.02 | 6.4e-04 | 5.5 | 3.80e-08 | 0.03 | FALSE |
| NAcc | Plekha7 | gene expression | Plekha7 | 0.03 | 1041 | 0.03 | 5.8e-05 | -5.54 | 2.97e-08 | 0.5 | FALSE |
| NAcc | Nucb2 | mRNA stability | Nucb2 | 0.03 | 1 | 0.02 | 5.8e-04 | 5.49 | 4.09e-08 | 0.05 | FALSE |
| NAcc | Sox6 | mRNA stability | Sox6 | 0.03 | 881 | 0.02 | 2.3e-04 | -5.46 | 4.78e-08 | 0.52 | FALSE |
| OFC | Plekha7 | gene expression | Plekha7 | 0.38 | 136 | 0.13 | 6.1e-04 | -5.55 | 2.91e-08 | 0.43 | FALSE |
| PL | Plekha7 | gene expression | Plekha7 | 0.03 | 1041 | 0.02 | 1.2e-03 | -5.48 | 4.16e-08 | 0.45 | FALSE |
| PL | Sox6 | mRNA stability | Sox6 | 0.04 | 881 | 0.03 | 1.1e-04 | -5.47 | 4.59e-08 | 0.53 | FALSE |
| pVTA | C1h11orf58 | gene expression | C1h11orf58 | 0.04 | 882 | 0.02 | 8.0e-03 | 5.47 | 4.52e-08 | 0.46 | FALSE |
| pVTA | LOC120099912 | gene expression | LOC120099912 | 0.11 | 1037 | 0.11 | 3.8e-09 | -5.49 | 3.95e-08 | 0.49 | FALSE |
| pVTA | Plekha7 | gene expression | Plekha7 | 0.17 | 1041 | 0.18 | 1.2e-14 | -5.49 | 4.03e-08 | 0.49 | FALSE |
| pVTA | Rps13 | gene expression | Rps13 | 0.03 | 1055 | 0.01 | 3.0e-02 | -5.52 | 3.32e-08 | 0.36 | FALSE |
| pVTA | Plekha7 | isoform ratio | XM_063279492.1 | 0.04 | 1041 | 0.02 | 1.1e-02 | -5.53 | 3.26e-08 | 0.42 | FALSE |
| pVTA | Plekha7 | intron excision ratio | chr1_179800164_179803798 | 0.05 | 1041 | 0.04 | 6.2e-04 | -5.49 | 3.95e-08 | 0.46 | FALSE |
| pVTA | Plekha7 | intron excision ratio | chr1_179833716_179836198 | 0.05 | 1041 | 0.02 | 4.5e-03 | -5.53 | 3.25e-08 | 0.44 | FALSE |