Hub : Genes

Scn3a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA intron excision ratio chr3_50216093_50216913 0.13 0.07 8.5e-04 0.04 0.05 0.02 0.03 5.1e-03 4.4e-03 4.9e-02 1.3e-02
2 NAcc gene expression Scn3a 0.07 0.04 3.3e-07 0.05 0.07 0.06 0.06 2.7e-06 3.0e-08 8.5e-08 1.1e-07
3 PL gene expression Scn3a 0.05 0.03 1.1e-04 0.03 0.03 0.03 0.03 7.7e-04 5.6e-04 2.8e-04 8.6e-04
4 Brain gene expression Scn3a 0.27 0.09 3.3e-16 0.12 0.18 0.17 0.18 1.7e-11 3.2e-16 1.2e-15 2.1e-16
5 OFC alternative TSS XM_039105647.1 0.18 0.09 6.8e-04 0.13 0.08 0.07 0.09 5.3e-04 5.6e-03 1.0e-02 3.2e-03
6 NAcc isoform ratio NM_013119.2 0.03 0.02 5.6e-04 0.04 0.03 0.03 0.03 1.1e-05 4.6e-04 3.6e-04 1.7e-04
7 BLA gene expression Scn3a 0.11 0.05 1.6e-05 0.08 0.09 0.07 0.08 5.0e-05 2.5e-05 1.6e-04 5.3e-05
8 Brain alternative polyA NM_013119.2 0.06 0.04 6.0e-03 0 0.01 0.03 0.01 1.2e-01 1.6e-02 1.0e-03 1.6e-02
9 Brain isoform ratio XM_008761914.3 0.07 0.04 5.0e-05 0.06 0.05 0.04 0.05 3.3e-06 2.3e-05 1.0e-04 1.3e-05
10 Brain mRNA stability Scn3a 0.09 0.06 2.5e-03 0.02 0.03 0.04 0.03 3.3e-03 5.6e-04 6.0e-05 4.2e-04
11 Brain intron excision ratio chr3_50179376_50183472 0.03 0.02 9.2e-03 0.02 0.02 0.02 0.01 3.1e-03 9.5e-03 8.4e-03 1.6e-02
12 Brain alternative polyA XM_008761914.3 0.09 0.04 1.0e-04 0.03 0.04 0.04 0.04 3.9e-04 7.4e-05 2.5e-04 8.3e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.81.33.5-0.6-0.41.6-0.81.9-1.7-1.20.1-1.3-0.51.6-0.1
Area under the delay curve0.30.30.9-0.8-1.0-0.30.5-0.60.10.1-0.20.7-0.4-0.2-0.6
BMI with tail0.10.41.30.50.80.8-0.21.2-0.6-0.5-0.8-0.2-0.90.5-0.4
BMI without tail0.20.30.9-0.2-0.3-0.10.6-0.40.90.60.10.7-0.9-0.9-0.3
Body weight0.10.51.70.81.31.1-0.41.3-0.5-0.10.4-0.6-0.30.50.3
Weight adjusted by age0.30.41.6-0.5-0.20.40.00.6-0.7-0.3-1.3-0.2-0.60.9-0.8
Bone surface0.71.22.60.0-0.11.2-0.81.6-1.3-1.30.9-1.6-0.31.40.8
Bone volume0.30.61.50.00.11.0-0.31.2-1.0-0.70.5-1.0-0.91.00.2
Breakpoint value in progressive ratio session1.01.14.5-2.1-2.00.6-0.90.4-0.4-0.7-1.30.20.4-0.2-0.7
Number of licking bursts1.21.42.6-0.4-0.21.4-1.51.2-0.9-0.91.3-1.41.61.31.0
Context. condit. distance diff. score0.50.71.9-0.8-0.3-0.10.6-0.90.71.4-0.61.1-0.3-0.5-1.3
Locomotion velocity, session 10.10.20.6-0.1-0.2-0.5-0.3-0.2-0.2-0.4-0.7-0.00.80.1-0.2
Locomotion distance, session 10.10.10.5-0.2-0.20.10.2-0.2-0.4-0.20.00.2-0.20.7-0.4
Locomotion velocity, session 20.20.20.6-0.2-0.5-0.70.0-0.60.5-0.2-0.40.10.5-0.7-0.2
Locomotion distance, session 20.30.41.41.21.0-0.30.40.0-0.2-0.31.0-0.5-0.50.00.8
Locomotion velocity, session 30.20.30.7-0.4-0.20.7-0.20.7-0.8-0.5-0.4-0.30.30.6-0.5
Locomotion distance, session 30.70.81.4-0.6-0.70.8-1.01.0-0.9-1.00.7-1.20.90.70.8
Stereotopy head waving bouts, day 31.01.14.01.21.40.6-0.50.4-0.8-0.52.0-1.10.70.71.5
Stereotopy head waving duration, day 30.50.62.21.21.50.10.2-0.3-0.00.21.4-0.30.1-0.20.8
Locomotion velocity, session 70.10.10.50.20.1-0.70.1-0.20.20.00.4-0.10.3-0.50.7
Locomotion distance, session 70.20.31.10.50.4-0.1-0.40.20.0-0.30.8-0.60.6-0.51.0
Stereotopy head waving bouts, day 71.31.53.1-0.5-0.31.4-1.31.2-1.3-1.21.4-1.81.20.91.2
Stereotopy head waving duration, day 71.51.93.3-0.9-0.51.6-1.61.4-1.4-1.21.4-1.81.61.21.3
Locomotion velocity, session 80.50.61.5-0.3-0.3-0.70.7-0.91.21.2-0.21.1-0.3-0.6-0.7
Locomotion distance, session 80.10.20.9-0.40.20.30.4-0.3-0.10.8-0.30.5-0.20.2-1.0
Degree of sensitization distance0.20.20.70.20.70.10.3-0.60.50.80.10.5-0.2-0.7-0.3
Degree of sensitization stereotypy1.61.83.4-1.3-1.01.8-1.41.6-1.7-1.50.2-1.51.01.50.2
Conditioned locomotion0.30.31.1-0.3-0.00.8-0.30.4-0.9-0.30.9-0.40.31.10.3
Cocaine response after cond. corrected0.50.51.9-1.1-0.50.9-0.20.1-0.50.1-1.20.60.4-0.0-1.4
Cocaine response after cond. not corrected0.30.30.9-0.30.20.30.4-0.50.20.8-0.01.00.2-0.7-0.8
Cocaine response before conditioning1.01.23.91.21.0-0.90.9-1.01.21.12.00.4-0.4-1.11.1
Saline control response1.11.44.20.51.20.21.20.0-0.11.0-1.91.2-1.70.7-2.1
Bone: connectivity density1.93.06.2-0.9-0.82.3-1.62.5-2.5-2.00.2-2.10.32.40.4
Bone: cortical apparent density1.62.25.80.40.61.7-1.42.4-2.0-1.90.3-1.71.01.70.8
Bone: cortical area1.52.34.22.02.0-1.61.7-1.31.91.80.31.1-1.5-1.4-0.1
Bone: cortical porosity0.30.31.5-0.6-0.60.0-0.5-0.10.10.00.9-0.31.2-0.10.8
Bone: cortical porosity0.20.20.6-0.1-0.0-0.50.0-0.50.60.60.60.10.8-0.40.5
Bone: cortical thickness0.60.93.21.61.8-0.51.0-0.30.70.9-0.40.5-1.1-0.7-0.6
Bone: cortical thickness0.91.12.60.91.3-0.51.3-0.81.11.60.21.2-0.9-1.1-0.4
Bone: cortical tissue density1.92.56.70.30.51.9-1.62.6-2.1-2.10.3-1.91.01.80.9
Condit. Reinf. active minus inactive responses1.21.33.70.90.80.9-0.61.3-1.1-1.01.9-1.40.40.41.8
Condit. Reinf. active-inactive response ratio0.30.41.10.60.50.5-0.20.6-0.3-0.41.1-0.8-0.20.00.9
Condit. Reinf. active responses1.01.24.51.00.90.3-0.50.9-0.4-0.52.1-1.20.9-0.32.1
Condit. Reinf. inactive responses0.70.93.50.60.6-0.2-0.60.60.1-0.21.5-0.81.5-0.41.9
Incentive salience index mean1.92.25.31.00.81.1-1.01.9-1.3-1.52.3-2.00.60.52.3
Condit. Reinf. lever presses0.50.71.60.80.70.6-0.61.2-0.5-0.81.0-1.30.3-0.21.1
Condit. Reinf. active minus inactive responses2.43.07.72.62.8-1.42.5-1.21.01.80.21.2-2.3-0.8-0.3
Condit. Reinf. active-inactive response ratio1.92.04.42.12.0-1.42.0-1.30.81.20.21.0-2.0-0.8-0.2
Condit. Reinf. active responses1.72.48.42.62.9-1.02.1-0.50.91.70.41.0-1.7-0.70.0
Condit. Reinf. inactive responses0.40.51.70.71.3-0.10.8-0.20.71.30.00.7-0.3-0.4-0.4
Condit. Reinf. lever presses2.02.69.82.63.1-0.82.1-0.71.01.81.21.1-1.6-0.20.2
Condit. Reinf. lever reinforcers received2.02.78.72.72.9-1.22.3-0.81.01.70.11.1-2.0-0.6-0.3
Conditioned reinforcement - actives0.20.20.5-0.3-0.2-0.0-0.0-0.60.60.60.5-0.00.5-0.70.0
Conditioned reinforcement - inactives0.10.20.50.1-0.2-0.5-0.0-0.30.70.00.4-0.20.5-0.40.5
Conditioned locomotion0.91.02.4-0.2-0.0-0.70.8-1.51.21.50.11.40.2-1.6-0.8
Patch foraging indifference point 0 sec2.13.48.6-0.30.52.9-1.72.7-2.3-1.60.7-1.81.72.60.5
Patch foraging indifference point AUC1.41.65.40.5-0.2-1.81.5-1.71.71.00.81.0-0.6-2.30.4
Delay disc. indifference point, 0s delay0.30.31.00.60.60.2-0.11.0-0.8-0.60.1-0.1-0.21.00.4
Delay disc. indifference point, 16s delay0.30.31.3-0.9-1.10.4-0.60.2-0.1-0.50.5-0.40.4-0.10.4
Delay disc. indifference point, 2s delay0.30.41.40.80.1-0.5-0.10.6-0.5-1.20.2-0.6-0.20.60.8
Delay disc. indifference point, 24s delay0.70.73.2-1.7-1.80.2-0.6-0.40.2-0.10.3-0.10.8-0.70.1
Delay disc. indifference point, 4s delay1.01.13.7-0.5-0.5-0.81.2-0.6-0.30.4-1.91.3-1.10.3-1.7
Delay disc. indifference point, 8s delay0.80.91.9-0.5-0.6-0.61.1-1.30.80.8-0.21.2-1.4-0.7-1.1
Indifference point function ln k0.91.33.40.00.41.2-1.21.8-1.5-1.10.5-1.20.21.80.9
Indifference point function log k0.91.33.40.00.41.2-1.21.8-1.5-1.10.5-1.20.21.80.9
Patch foraging total patch changes 0 sec2.23.59.0-0.60.33.0-1.72.7-2.5-1.70.2-1.71.52.80.1
Patch foraging total patch changes 12 sec0.10.20.50.60.4-0.20.30.00.40.10.7-0.10.6-0.20.5
Patch foraging total patch changes 18 sec0.30.42.40.20.00.4-0.30.40.2-0.31.6-0.60.6-0.41.1
Patch foraging total patch changes 24 sec0.60.83.31.61.80.10.80.00.90.90.60.2-0.7-0.5-0.0
Patch foraging total patch changes 6 sec0.71.12.9-0.5-0.41.7-1.01.2-1.0-1.00.6-1.11.41.10.4
Patch foraging time to switch 0 sec0.40.51.2-0.9-0.70.9-1.00.6-0.5-0.3-0.6-0.21.01.1-0.5
Patch foraging water rate 0 sec0.60.93.11.11.1-0.0-0.20.6-0.1-0.51.6-1.2-0.2-0.61.7
Patch foraging water rate 12 sec0.60.92.91.71.6-1.10.6-0.20.70.20.8-0.2-0.6-0.71.1
Patch foraging water rate 18 sec1.62.23.61.71.9-1.61.9-1.21.31.4-1.11.3-1.8-1.0-0.9
Patch foraging water rate 24 sec0.40.51.00.60.7-0.71.0-0.90.70.7-0.10.7-0.9-0.0-0.6
Patch foraging water rate 6 sec0.40.71.61.31.2-1.20.1-0.60.80.40.8-0.4-0.4-0.71.0
Seeking ratio, delayed vs. immediate footshock0.20.20.90.60.5-0.20.3-0.00.10.10.90.2-0.1-0.40.5
Distance traveled before self-admin0.40.51.80.80.7-0.1-0.50.10.50.21.4-0.20.7-0.51.1
Distance traveled after self-admin0.80.92.91.31.0-0.90.1-0.41.10.21.50.00.7-0.81.7
Extensor digitorum longus weight0.41.77.62.82.4-0.91.20.40.50.20.7-0.1-1.9-0.30.6
Bone: elastic displacement0.20.20.50.70.5-0.10.4-0.40.2-0.0-0.40.1-0.7-0.3-0.6
Bone: elastic work2.12.78.52.32.4-0.82.0-1.00.61.0-1.30.9-2.9-0.5-1.9
Bone: endosteal estimation1.94.18.70.70.3-2.72.3-2.82.92.60.42.2-1.7-2.2-0.4
Bone: endosteal perimeter1.83.77.31.71.3-2.72.5-2.22.42.30.61.9-1.9-1.80.2
Epididymis fat weight2.45.611.5-3.4-2.53.2-1.82.0-2.4-1.6-3.1-0.30.02.3-2.9
Delta time in closed arm before/after self-admin0.50.52.20.91.0-0.00.6-0.2-0.40.1-0.7-0.0-1.50.7-0.7
Delta time in open arm before/after self-admin0.70.72.30.70.50.3-0.80.80.2-0.41.5-0.51.5-0.21.1
Diff in mean of infusions in LGA sessions5.86.417.9-4.2-4.03.0-2.91.9-2.3-2.3-1.6-1.41.31.9-1.1
Delay discount exponential model param0.40.41.30.91.10.4-0.50.8-0.3-0.20.3-0.80.50.50.7
Extinction: sum of active levers before priming0.10.10.3-0.10.40.0-0.20.20.00.4-0.50.20.60.0-0.1
Active lever presses in extinction session 62.22.23.90.10.01.4-1.72.0-1.6-1.90.9-1.71.32.01.4
Bone: final force4.47.112.41.91.4-3.43.0-3.43.53.0-0.22.5-2.9-3.2-0.6
Bone: final moment5.18.313.92.21.7-3.63.3-3.53.73.3-0.42.8-3.2-3.4-0.8
Food consumed during 24 hour testing period0.40.52.01.31.4-0.00.40.4-0.10.30.6-0.2-1.00.20.4
Glucose0.60.93.10.80.5-1.71.2-0.81.00.6-0.90.8-1.2-1.0-0.2
Heart weight0.20.30.9-0.40.30.3-0.20.10.00.8-1.00.20.90.5-0.6
Delay discount hyperbolic model param0.50.51.00.70.90.7-0.80.9-0.4-0.30.6-1.00.70.50.9
Intermittent access intake day 1-15 change1.01.02.61.51.3-1.61.2-0.70.41.00.10.3-1.1-1.00.5
Intermittent access intake escalation1.41.43.51.61.3-1.91.5-1.00.71.1-0.20.8-1.3-1.20.2
Intermittent access intake escalation 21.61.63.61.51.4-1.51.8-0.90.91.2-0.71.0-1.9-1.2-0.3
Intermitt. access day 1 inactive lever presses2.02.14.41.51.20.9-1.01.7-1.1-1.32.0-1.61.70.82.1
Intermitt. access day 15 inactive lever presses0.60.61.71.20.7-0.70.1-0.50.2-0.11.3-0.11.3-0.31.0
Intermitt. access escalation Index0.60.52.20.30.40.5-0.50.7-1.1-0.70.0-0.9-0.21.50.5
Intermittent access day 1 total infusions0.40.41.6-1.1-1.00.6-0.70.10.30.00.5-0.11.2-0.40.2
Intermittent access day 15 total infusions0.70.82.60.30.0-1.10.6-1.01.51.00.70.60.1-1.60.4
Intermittent access terminal intake (last 3 days)0.40.51.00.70.8-0.70.8-0.61.00.90.10.3-0.7-0.9-0.0
Intermittent access total infusions0.20.31.0-0.3-0.2-0.20.3-0.61.00.70.20.50.3-0.8-0.1
Intermittent access day 1 locomotion0.40.52.0-0.9-0.70.5-0.5-0.10.70.40.60.41.4-0.8-0.1
Intermittent access day 15 total locomotion0.60.61.60.50.8-0.90.7-0.80.81.3-0.50.9-0.1-1.0-0.4
Intermittent access total locomotion0.20.20.90.10.5-0.00.4-0.40.60.90.00.60.4-0.6-0.5
Intermittent access standard deviation1.82.05.11.41.0-2.11.3-1.31.91.40.21.1-0.3-2.30.5
Left kidney weight1.13.09.02.63.0-1.61.8-1.21.82.2-0.61.4-1.1-1.3-0.5
Right kidney weight0.72.010.82.93.3-0.81.20.20.50.9-0.80.2-1.0-0.1-0.3
Cocaine induced anxiety1.11.34.00.30.4-0.21.5-1.0-0.30.6-1.51.2-2.0-0.0-2.0
Post-drug Anxiety0.20.20.60.30.2-0.40.7-0.7-0.20.4-0.00.7-0.1-0.2-0.7
Baseline Anxiety1.61.75.6-0.1-0.20.5-1.61.3-0.5-0.91.8-1.22.40.52.0
Tail length0.41.35.7-0.5-0.6-0.3-0.0-0.91.50.92.4-0.10.7-1.81.5
Length with tail0.10.30.80.40.80.5-0.30.40.10.40.9-0.50.3-0.20.6
Length without tail0.30.72.21.01.50.7-0.51.1-1.0-0.3-0.5-0.70.41.3-0.0
Times rat made contact with spout0.70.81.90.70.9-0.41.1-0.70.10.6-1.01.1-1.30.0-1.4
Lifetime Intake0.20.20.8-0.5-0.6-0.2-0.2-0.40.90.30.50.10.4-0.70.3
Liver weight, left2.23.65.60.40.3-2.21.7-2.32.42.1-2.22.0-1.5-2.0-2.1
Liver weight, right2.03.37.21.91.5-2.71.9-1.82.11.7-1.31.8-1.0-2.2-0.9
Locomotor activity0.60.94.72.22.1-0.40.60.10.10.20.5-0.0-0.8-0.30.6
Locomotor testing distance1.22.09.13.03.0-1.01.2-0.00.70.90.30.5-1.2-0.60.6
Locomotor testing rearing2.64.013.83.73.7-2.02.0-1.11.71.60.71.1-1.3-1.10.9
Locomotion in novel chamber0.50.63.0-1.1-1.40.3-0.8-0.10.0-0.40.4-0.31.70.50.2
Locomotion in novel chamber post-restriction0.40.41.30.40.91.00.01.1-0.6-0.0-0.40.10.10.9-0.7
Fecal boli incidents, locomotor time 12.83.05.5-2.0-1.62.0-2.32.0-1.2-1.41.7-1.81.80.11.9
Change in fecal boli incidents, locomotor task0.70.71.71.10.6-1.01.0-1.01.30.70.60.7-0.3-0.70.1
Time >=10cm from walls, locomotor time 10.10.10.50.50.5-0.20.1-0.20.70.30.6-0.0-0.1-0.30.2
Bouts of movement, locomotor time 12.02.27.0-2.6-2.02.3-1.81.1-1.1-0.8-0.6-1.10.60.5-1.3
Total resting periods, locomotor time 12.12.37.6-2.8-2.22.3-1.81.2-1.0-0.8-0.8-1.00.50.2-1.3
Rest time, locomotor task time 11.11.24.5-2.1-1.71.6-1.10.7-0.1-0.10.5-0.21.1-0.6-0.8
Distance moved, locomotor task time 11.82.08.22.92.7-1.51.6-0.3-0.10.3-1.00.6-1.01.00.3
Vertical activity count, locomotor time 12.52.64.82.01.7-2.02.2-1.51.11.2-1.91.5-1.7-0.5-1.1
Time >=10cm from walls, locomotor time 21.71.83.51.31.2-1.91.2-1.71.81.8-0.31.2-0.8-1.2-0.2
Bouts of movement, locomotor time 21.41.53.8-1.4-1.51.4-2.00.8-0.4-1.10.7-1.31.80.50.1
Total resting periods, locomotor time 22.42.65.9-1.9-1.92.1-2.41.4-1.1-1.60.7-1.71.91.0-0.0
Rest time, locomotor task time 21.92.17.1-1.4-0.92.7-1.62.0-1.3-1.21.6-1.21.30.60.2
Distance moved, locomotor task time 23.54.17.52.62.7-2.42.6-1.71.42.1-2.42.0-1.7-0.3-1.2
Vertical activity count, locomotor time 21.81.96.21.00.8-1.91.6-1.30.81.1-2.51.4-1.3-0.3-1.3
Light reinforcement 10.50.81.60.40.6-0.91.2-1.00.51.0-1.01.3-0.9-0.7-1.0
Light reinforcement 21.72.34.7-0.6-0.2-1.41.7-2.20.81.7-2.01.9-1.1-0.7-2.1
Bone: marrow area1.63.57.30.60.2-2.62.1-2.62.72.30.42.0-1.5-2.0-0.3
Bone: maximum diameter0.71.42.51.51.4-1.21.3-0.71.61.51.00.8-1.0-1.00.4
Bone: maximum force4.17.212.32.21.8-3.53.1-3.23.53.2-0.42.5-2.8-2.8-0.9
Bone: maximum moment4.98.514.12.42.1-3.73.4-3.43.83.5-0.72.8-3.1-3.1-1.1
Mean time between licks in bursts1.21.73.61.71.9-1.41.3-1.81.41.60.51.0-0.5-0.9-0.2
Mean num. licks in bursts1.92.35.51.00.9-1.42.0-1.30.71.1-1.91.8-2.3-1.0-1.8
Cd content in liver0.40.51.8-0.7-0.8-0.30.3-0.10.30.3-1.30.7-0.6-0.7-1.1
Co content in liver0.30.31.40.91.20.30.40.5-0.40.00.6-0.1-0.1-0.10.6
Cu content in liver0.20.30.9-0.3-0.8-0.9-0.2-0.30.2-0.30.5-0.30.3-0.31.0
Fe content in liver1.61.93.4-1.8-1.51.5-1.21.4-1.8-1.4-1.7-0.50.91.2-0.9
K content in liver0.70.71.70.40.4-1.30.9-1.31.01.0-0.11.00.3-1.0-0.1
Mg content in liver0.40.41.20.20.2-0.90.6-1.10.80.70.50.50.3-0.60.2
Mn content in liver0.50.62.31.51.1-0.60.30.2-0.1-0.21.2-0.40.10.11.2
Na content in liver0.60.71.50.60.6-1.10.7-0.71.21.1-0.31.00.5-0.9-0.1
Rb content in liver0.20.31.30.40.3-0.50.4-0.70.30.41.2-0.1-0.2-0.10.9
Se content in liver0.40.52.1-0.40.01.4-0.71.2-0.8-0.50.1-0.30.60.50.0
Sr content in liver0.50.52.01.41.4-0.10.20.3-0.00.00.8-0.00.20.40.8
Zn content in liver0.30.31.1-0.8-0.20.5-0.0-0.20.61.1-0.40.60.0-0.7-0.6
Bone: minimum diameter1.32.44.41.11.1-2.01.8-1.72.12.1-0.51.6-1.4-1.6-0.7
Time in familiar zone, hab. session 10.40.42.0-0.3-0.5-0.40.3-0.40.60.31.40.3-0.2-0.70.9
Time in novel zone, hab. session 10.70.74.10.30.50.10.10.5-0.7-0.3-2.00.1-0.40.9-1.2
Total zone transitions, hab. session 13.04.27.52.02.3-1.72.7-2.21.62.5-1.12.3-2.3-1.3-1.9
Total locomotion distance, hab. session 12.53.66.62.52.3-2.22.6-2.11.61.8-0.31.7-1.9-1.4-0.9
Locomotion velocity, hab. session 12.53.65.91.91.6-2.22.4-2.42.02.1-0.51.9-1.6-1.9-1.2
Time in familiar zone, hab. session 23.13.212.2-1.4-0.5-0.21.5-1.30.71.9-3.02.3-1.4-0.3-3.5
Time in novel zone, hab. session 22.62.69.30.70.20.6-1.61.3-0.8-1.72.5-2.11.40.23.0
Total zone transitions, hab. session 20.30.31.01.01.0-0.30.7-0.50.20.50.10.4-0.40.3-0.6
Total locomotion distance, hab. session 20.20.20.90.60.4-0.10.20.0-0.6-0.60.1-0.3-0.10.9-0.2
Locomotion velocity, hab. session 20.10.20.60.70.4-0.40.4-0.1-0.4-0.5-0.1-0.1-0.20.8-0.4
Novel to familiar place preference ratio0.30.31.4-0.10.41.2-0.40.9-0.6-0.20.2-0.40.20.6-0.0
Novelty place preference0.30.31.5-0.30.11.2-0.60.9-0.6-0.30.0-0.30.40.6-0.1
Time in novel zone, NPP test0.20.21.3-0.40.11.2-0.50.7-0.5-0.1-0.1-0.10.40.4-0.3
Total zone transitions, NPP test0.10.20.7-0.00.40.20.4-0.5-0.10.6-0.10.4-0.00.1-0.8
Total locomotion distance, NPP test0.30.41.01.00.9-0.70.8-0.90.20.40.40.2-0.5-0.1-0.2
Locomotion velocity, NPP test0.30.51.71.31.1-0.90.8-0.70.10.20.50.0-0.5-0.10.1
Intraocular pressure1.01.42.31.01.5-0.71.2-1.20.91.5-1.11.2-1.5-0.5-1.2
Delta distance traveled before/after self-admin0.10.10.50.50.1-0.70.3-0.10.2-0.40.1-0.00.20.00.5
Delta ambulatory time before/after self-admin0.40.41.51.00.7-1.20.6-0.50.60.00.60.1-0.0-0.30.9
Parametrial fat weight1.83.412.2-1.1-0.9-0.91.5-1.71.11.3-3.12.4-1.7-0.7-3.5
Pavlov. Cond. lever latency1.21.53.3-1.4-1.4-1.20.2-1.81.21.1-1.41.40.5-1.0-1.0
Pavlov. Cond. magazine entry latency0.40.51.0-0.4-0.40.6-0.71.0-0.5-0.60.9-1.00.90.01.0
Pavlov. Cond. change in total contacts2.12.24.30.3-0.21.1-1.51.9-1.2-1.91.9-2.11.40.72.1
Pavlov. Cond. index score1.51.94.30.80.61.2-1.02.1-1.1-1.41.8-2.00.90.61.9
Pavlov. Cond. latency score1.62.14.51.01.01.3-0.92.1-1.3-1.41.9-2.00.60.81.9
Pavlov. Cond. lever contacts2.22.66.60.90.91.8-1.22.6-1.8-1.81.6-2.20.51.41.5
Pavlov. Cond. magazine entry number1.72.14.4-0.00.6-0.71.4-1.81.11.9-1.72.0-1.4-0.7-2.1
Pavlov. Cond. intertrial magazine entries0.91.11.81.11.0-1.01.0-1.21.31.30.70.8-0.9-1.40.3
Pavlov. Cond. lever-magazine prob. diff.1.31.63.90.60.41.1-1.12.0-0.9-1.31.6-1.81.00.41.7
Pavlov. Cond. response bias2.12.65.60.0-0.51.2-1.62.2-1.4-2.11.8-2.41.30.92.1
Pavlov. Cond. lever latency0.81.14.5-2.0-2.10.3-0.8-0.0-0.3-0.6-1.3-0.10.9-0.1-1.0
Pavlov. Cond. magazine entry latency0.40.41.0-1.0-0.80.8-0.8-0.2-0.3-0.11.0-0.40.70.20.3
Pavlov. Cond. change in total contacts0.50.73.10.50.30.2-0.70.3-0.3-0.61.8-1.10.60.51.6
Pavlov. Cond. index score0.20.21.50.30.60.5-0.1-0.2-0.20.21.2-0.20.10.40.5
Pavlov. Cond. latency score0.20.31.4-0.00.20.7-0.40.1-0.5-0.11.2-0.50.40.70.6
Pavlov. Cond. lever contacts0.81.15.01.92.20.30.40.5-0.30.21.4-0.4-0.70.71.0
Pavlov. Cond. magazine entry number0.70.92.21.51.4-1.01.3-0.20.70.6-0.60.8-1.0-0.7-0.3
Pavlov. Cond. intertrial magazine entries1.11.44.32.11.7-1.61.7-0.20.80.7-0.30.8-1.4-0.60.1
Pavlov. Cond. lever-magazine prob. diff.0.20.21.60.20.40.4-0.3-0.1-0.3-0.11.3-0.40.10.50.7
Pavlov. Cond. response bias0.40.52.41.21.50.10.4-0.10.20.61.00.0-0.60.20.5
Time in closed arm before self-admin0.20.31.0-0.8-0.80.2-0.40.20.2-0.10.30.01.0-0.60.4
Time in closed arm after self-admin0.40.40.80.20.1-0.80.7-0.90.70.7-0.50.5-0.4-0.8-0.2
Time in open arm before self-admin1.21.33.2-1.7-1.81.2-1.10.9-1.5-1.1-0.2-0.9-0.61.0-0.3
Time in open arm after self-admin1.92.14.2-0.4-0.51.7-1.91.7-1.1-1.52.0-1.61.51.11.4
Bone: periosteal estimation1.83.87.71.61.4-2.52.3-2.32.82.50.51.8-1.8-2.0-0.1
Bone: periosteal perimeter1.22.03.92.01.8-1.81.6-1.21.61.50.90.8-1.1-1.20.8
Bone: post-yield work0.40.51.10.80.8-1.00.7-0.81.01.00.20.6-0.4-0.50.2
Progressive ratio test 1 active lever presses1.41.54.00.40.11.0-1.31.2-0.2-1.02.0-1.81.40.91.6
Progressive ratio test 1 breakpoint0.91.03.50.70.50.7-0.90.90.2-0.51.9-1.51.00.51.4
Progressive ratio test 1 inactive lever presses0.50.52.11.51.40.30.10.40.20.21.2-0.10.4-0.10.6
Progressive ratio test 2 active lever presses0.30.30.8-0.6-0.50.1-0.5-0.50.50.30.9-0.40.8-0.50.5
Progressive ratio test 2 breakpoint0.30.31.2-0.3-0.20.2-0.5-0.30.10.21.1-0.60.9-0.20.7
Progressive ratio test 2 inactive lever presses0.70.82.6-0.4-0.7-0.4-0.4-0.70.80.21.5-0.11.6-1.21.0
Incentive Sensitization - Responses0.40.41.6-0.40.1-0.30.3-1.20.71.30.10.2-0.3-0.6-0.1
Incentive Sensitization - Breakpoint0.50.52.1-0.30.2-0.50.5-1.40.81.50.10.4-0.3-0.8-0.2
Sum of active levers in priming session hrs 5-61.31.33.1-1.1-1.21.0-1.81.3-0.9-1.60.1-1.50.50.60.9
Progressive ratio0.70.83.7-0.6-0.80.4-1.40.1-0.1-0.61.2-0.81.90.40.8
Food seeking constrained by brief footshock0.50.63.3-1.6-1.80.1-0.5-0.2-0.1-0.4-0.8-0.10.0-0.1-0.3
Seeking ratio, punishment vs. effort0.40.52.6-0.0-0.1-0.30.80.10.10.1-1.30.4-1.6-0.5-0.5
Retroperitoneal fat weight2.68.536.4-0.90.3-0.52.3-1.30.72.4-6.03.4-2.70.0-5.7
Reaction time number correct1.42.05.12.22.1-1.81.7-1.21.21.1-0.80.7-1.5-0.8-0.6
Reaction time mean minus median0.91.25.2-2.1-2.30.2-0.6-1.00.80.3-0.80.50.7-0.4-1.0
Reaction time mean minus median AUC1.01.44.6-2.0-2.20.2-0.2-1.00.60.3-1.60.7-0.10.0-1.8
Reaction time num false alarms5.47.412.32.72.3-3.53.1-3.43.43.00.62.9-1.3-3.40.1
Reaction time num false alarms AUC4.76.511.42.72.1-3.42.7-3.13.32.61.12.6-1.0-3.40.5
Reaction time trials correct on left1.42.05.12.22.1-1.81.7-1.21.21.1-0.80.7-1.5-0.8-0.6
Reaction time trials on left1.42.04.92.22.1-1.81.7-1.31.21.2-0.80.8-1.5-0.9-0.7
Reaction time mean1.52.111.2-3.2-3.30.4-0.9-0.8-0.2-0.4-0.60.40.60.4-1.0
Reaction time mean AUC1.62.211.4-3.3-3.40.6-1.0-0.6-0.3-0.5-0.60.20.80.4-1.1
Median of all reaction times1.52.110.3-3.1-3.20.5-0.9-0.4-0.9-0.7-0.60.10.50.9-0.9
Reaction time omissions0.60.81.8-1.1-1.1-0.40.2-1.30.80.9-0.80.90.3-0.4-1.3
Reaction time false alarm rate1.82.55.31.30.9-1.81.5-1.92.11.71.51.9-0.2-2.30.8
Reaction time premature initiation rate0.30.40.9-0.4-0.10.10.5-0.40.70.9-0.30.9-0.8-0.7-0.8
Reaction time premature initiations1.31.82.80.91.1-1.11.6-1.31.61.7-0.91.5-1.6-1.5-1.2
Std. dev. reaction times1.01.47.0-2.2-2.6-0.1-0.6-1.21.00.3-0.30.60.8-0.6-0.8
Reaction time trials completed1.42.04.92.22.1-1.81.7-1.31.21.2-0.80.8-1.5-0.9-0.7
Reaction time trials AUC1.82.55.92.42.3-2.01.9-1.31.31.3-0.90.9-1.8-1.0-0.7
Run reversals in cocaine runway, females1.01.01.80.40.8-0.81.1-0.61.11.2-1.21.20.2-1.4-1.1
Run reversals in cocaine runway, males2.12.08.1-0.6-0.3-0.51.7-0.30.10.8-2.81.9-1.50.0-2.4
Latency to leave start box in cocaine runway0.30.30.8-0.10.30.30.8-0.2-0.70.3-0.50.4-0.90.5-0.9
Latency to leave start box in cocaine runway, F0.40.51.60.10.61.00.20.7-1.3-0.20.6-0.2-0.31.20.1
Latency to leave start box in cocaine runway, M0.40.31.2-0.8-0.70.3-0.1-0.1-0.5-0.2-1.1-0.1-0.30.1-1.1
Std. dev. time between licks in bursts0.60.82.91.51.3-0.30.2-0.30.50.21.7-0.3-0.4-0.11.2
Total sessions with >9 infusions1.21.34.5-1.2-1.40.0-1.0-0.51.20.31.80.02.1-0.91.0
Short access day 1 total inactive lever presses0.20.20.80.80.3-0.90.2-0.60.3-0.10.4-0.00.6-0.70.4
Short access day 10 total inactive lever presses0.40.51.41.21.0-0.60.4-0.10.10.20.7-0.1-0.9-0.61.0
Short access day 1 total infusions0.50.61.8-0.5-0.8-0.70.1-1.31.20.8-0.20.5-0.0-1.1-0.5
Short access day 10 total infusions0.40.41.90.70.60.3-0.40.30.50.11.4-0.41.1-0.20.9
Short access total infusions0.30.30.9-0.8-1.00.1-0.7-0.00.4-0.10.5-0.40.6-0.40.5
Short access day 1 locomotion0.60.61.6-0.3-0.2-0.60.2-1.21.01.30.20.80.9-1.0-0.4
Short access day 10 total locomotion0.30.30.8-0.6-0.40.1-0.2-0.90.80.80.30.50.4-0.7-0.4
Short access total locomotion1.21.33.3-0.7-0.8-0.40.1-1.51.71.40.81.11.0-1.8-0.4
One hour access (0.3 mA shock)0.81.03.10.50.5-0.90.9-1.31.81.50.51.0-0.1-1.1-0.2
Compulsive drug intake0.60.61.9-0.1-0.5-1.30.1-1.40.90.3-0.10.81.0-1.2-0.1
One hour access (shock baseline)0.30.30.90.40.70.40.80.10.60.8-0.10.3-0.90.0-0.6
Social response proportion0.60.63.4-1.5-1.80.1-0.7-0.5-0.3-0.6-0.2-0.30.50.1-0.2
Social responses0.60.71.90.6-0.0-1.30.3-1.21.00.41.2-0.10.3-1.01.4
Social time1.01.33.3-0.3-1.1-0.8-0.5-1.11.70.21.80.01.6-1.31.2
Soleus weight0.72.04.11.10.9-2.01.5-1.41.81.4-0.81.4-1.1-1.9-0.6
Bone: stiffness3.45.310.81.81.2-3.32.5-3.03.32.60.42.1-1.9-2.80.2
Tibialis anterior weight0.20.61.2-0.2-0.31.0-0.71.1-0.9-1.10.8-1.00.20.60.7
Time to tail flick, vehicle, before self-admin0.90.92.9-1.5-1.50.1-0.1-0.61.10.80.50.70.6-1.7-0.0
Time to tail flick, vehicle, after self-admin0.80.92.3-1.5-1.30.7-0.80.7-1.3-1.0-1.3-0.10.40.7-0.6
Time to tail flick, test, before self-admin1.81.84.50.60.6-0.62.0-1.20.61.0-1.91.5-1.8-0.2-2.1
Time to tail flick, test, after self-admin0.10.10.6-0.1-0.2-0.3-0.3-0.10.3-0.3-0.20.00.8-0.40.2
Delta time to tail flick, vehicle, before/after SA1.61.55.80.40.50.7-0.41.3-2.3-1.6-0.9-0.9-0.32.4-0.0
Delta time to tail flick, test, before/after SA0.60.61.4-1.1-1.10.3-1.20.3-0.2-0.60.6-0.61.2-0.10.8
Tibia length0.82.49.32.33.0-1.01.8-0.90.82.01.20.6-1.5-0.30.6
Ambulatory time before self-admin0.50.51.30.50.7-0.3-0.2-0.30.80.71.10.30.9-0.90.8
Ambulatory time after self-admin0.70.81.90.90.7-1.10.5-0.81.40.61.10.60.4-1.11.2
Bone: tissue strength1.01.01.91.31.1-1.21.0-0.71.10.9-0.60.7-1.0-1.4-0.3
Total heroin consumption1.92.25.4-1.3-1.61.1-2.31.4-1.0-1.90.9-1.61.70.81.3
Bone: trabecular number1.32.14.5-1.0-0.62.1-1.32.1-2.1-1.5-0.1-1.7-0.01.9-0.1
Bone: trabecular spacing2.43.15.91.31.1-2.12.0-2.42.12.0-0.72.2-1.4-2.0-0.9
Bone: trabecular thickness0.10.20.6-0.4-0.20.5-0.40.8-0.5-0.40.1-0.50.00.40.1
Bone: trabecular tissue density0.10.20.60.70.5-0.60.4-0.20.1-0.10.30.30.0-0.20.5
Water consumed over 24 hours0.50.61.91.31.30.4-0.00.9-0.2-0.21.4-0.5-0.00.31.0
Number of responses in last shaping day1.41.43.0-1.1-1.60.8-1.50.4-0.3-1.01.7-1.41.70.41.0