Hub : Traits : Retroperitoneal fat weight : ← : →

chr3:118,826,966-120,490,128

Trait: Retroperitoneal fat weight

Best TWAS P = 3.93e-09 · Best GWAS P= 1.40e-08 conditioned to 1.00e+00

Associated models

Tissue	Gene	RNA modality	RNA phenotype	h2	# weights	Model R2	Model R2 P	TWAS Z	TWAS P	Coloc P	Joint
Adipose	Slc12a6	gene expression	Slc12a6	0.29	1136	0.21	1.2e-22	-5.26	1.44e-07	0.49	FALSE
Adipose	Slc12a6	mRNA stability	Slc12a6	0.03	1136	0.02	4.7e-03	5.39	7.23e-08	0.37	FALSE
BLA	Lpcat4	gene expression	Lpcat4	0.11	1	0.06	2.6e-04	-5.46	4.75e-08	0.05	FALSE
BLA	Nutm1	gene expression	Nutm1	0.42	1	0.23	2.9e-12	-5.3	1.14e-07	0.35	FALSE
BLA	Emc4	mRNA stability	Emc4	0.08	1	0.05	1.0e-03	-5.3	1.14e-07	0.07	FALSE
Brain	Slc12a6	alternative TSS	XM_006234710.5	0.03	1	0.03	1.8e-03	5.3	1.15e-07	0.04	FALSE
Brain	Emc4	gene expression	Emc4	0.08	39	0.08	1.2e-07	-5.29	1.22e-07	0.5	FALSE
Brain	Emc7	gene expression	Emc7	0.04	955	0.03	1.3e-03	5.81	6.19e-09	0.5	TRUE
Brain	Lpcat4	gene expression	Lpcat4	0.07	1113	0.1	3.3e-09	-5.42	6.11e-08	0.48	FALSE
Brain	Slc12a6	isoform ratio	XM_006234710.5	0.03	122	0.04	2.4e-04	5.44	5.28e-08	0.47	FALSE
Brain	Emc4	mRNA stability	Emc4	0.13	1119	0.17	2.9e-15	-5.54	3.07e-08	0.5	FALSE
Brain	Emc7	mRNA stability	Emc7	0.03	5	0.04	5.4e-05	-5.89	3.93e-09	0.54	TRUE
Brain	Lpcat4	mRNA stability	Lpcat4	0.06	1	0.04	1.0e-04	-5.36	8.52e-08	0.09	FALSE
IC	Aven	gene expression	Aven	0.06	1	0.03	2.7e-02	-5.24	1.59e-07	0.04	FALSE
IC	Emc4	gene expression	Emc4	0.12	1	0.1	5.4e-05	-5.36	8.30e-08	0.09	FALSE
IC	Nutm1	gene expression	Nutm1	0.2	1132	0.13	5.0e-06	-5.57	2.54e-08	0.48	FALSE
IC	Emc4	mRNA stability	Emc4	0.13	26	0.14	1.5e-06	-5.32	1.06e-07	0.49	TRUE
IL	Chrm5	gene expression	Chrm5	0.32	821	0.04	4.9e-02	-5.61	2.06e-08	0.27	FALSE
IL	Emc4	mRNA stability	Emc4	0.17	1	0.1	2.1e-03	-5.31	1.07e-07	0.06	FALSE
LHb	Nutm1	gene expression	Nutm1	0.11	1132	0.09	3.5e-03	-5.21	1.86e-07	0.31	FALSE
Liver	Aven	gene expression	Aven	0.13	846	0.05	2.8e-06	-5.44	5.23e-08	0.6	FALSE
NAcc	Lpcat4	alternative TSS	NM_001106494.1	0.01	1	0.01	8.0e-03	5.51	3.69e-08	0.03	FALSE
NAcc	Lpcat4	alternative TSS	XM_063283314.1	0.01	1113	0.01	3.4e-02	-5.37	7.88e-08	0.37	FALSE
NAcc	Aven	gene expression	Aven	0.09	1	0.1	4.7e-15	-5.67	1.40e-08	0.87	FALSE
NAcc	Lpcat4	gene expression	Lpcat4	0.04	1113	0.03	1.1e-05	-5.6	2.16e-08	0.49	FALSE
NAcc	Nop10	gene expression	Nop10	0.01	1133	0.01	8.1e-03	-5.5	3.81e-08	0.37	FALSE
NAcc	Nutm1	gene expression	Nutm1	0.12	1132	0.15	4.4e-22	-5.57	2.53e-08	0.5	FALSE
OFC	Nutm1	gene expression	Nutm1	0.13	63	0.08	5.8e-03	-5.38	7.45e-08	0.3	FALSE
OFC	Slc12a6	gene expression	Slc12a6	0.17	1	0.04	4.8e-02	5.3	1.19e-07	0.05	FALSE
PL	Lpcat4	alternative TSS	NM_001106494.1	0.03	1113	0.01	1.1e-02	5.58	2.36e-08	0.4	FALSE
PL	Lpcat4	alternative TSS	XM_063283314.1	0.03	1113	0.01	8.5e-03	-5.58	2.35e-08	0.42	FALSE
PL	Aven	gene expression	Aven	0.04	24	0.04	1.2e-05	-5.33	9.61e-08	0.59	FALSE
PL	Emc4	gene expression	Emc4	0.08	1	0.12	9.1e-13	-5.38	7.31e-08	0.49	FALSE
PL	Nutm1	gene expression	Nutm1	0.12	1	0.18	4.3e-19	-5.31	1.07e-07	0.36	FALSE
PL	Lpcat4	isoform ratio	NM_001106494.1	0.03	1	0.02	3.6e-03	5.35	8.77e-08	0.03	FALSE
PL	Lpcat4	isoform ratio	XM_063283314.1	0.03	1113	0.02	5.4e-03	-5.55	2.85e-08	0.41	FALSE
pVTA	Aven	gene expression	Aven	0.26	846	0.25	5.7e-20	-5.34	9.43e-08	0.6	FALSE
pVTA	Emc4	gene expression	Emc4	0.04	1119	0.05	1.2e-04	-5.37	7.93e-08	0.5	FALSE
pVTA	Nutm1	gene expression	Nutm1	0.07	5	0.09	1.1e-07	-5.38	7.40e-08	0.5	FALSE
pVTA	Slc12a6	gene expression	Slc12a6	0.04	1136	0.03	9.2e-04	-5.52	3.43e-08	0.46	FALSE
pVTA	Aven	intron excision ratio	chr3_119789454_119881163	0.09	38	0.11	4.2e-09	5.43	5.70e-08	0.58	FALSE
pVTA	Emc4	mRNA stability	Emc4	0.03	1	0.03	1.3e-03	-5.36	8.30e-08	0.04	FALSE