Hub : Genes

Wt1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Wt1	0.12	0.13	1.9e-09	0.07	0.06	0.06	0.07	2.7e-08	4.9e-07	1.4e-07	1.8e-08
2	Adipose	alternative TSS	XM_017591477.3	0.02	0.02	9.8e-03	0.01	0.01	0	0.01	2.9e-02	3.3e-02	1.1e-01	4.8e-02
3	Adipose	alternative TSS	XM_063283114.1	0.04	0.04	4.6e-04	0.02	0.02	0.02	0.02	1.9e-03	3.0e-03	5.5e-03	3.5e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.8	1.4	1.4	1.2	1.2	-1.2
Area under the delay curve	0.3	0.4	0.4	-0.6	-0.6	0.6
BMI with tail	0.0	0.0	0.0	0.1	0.1	-0.1
BMI without tail	0.2	0.7	0.8	0.8	0.9	-0.9
Body weight	0.6	2.5	2.5	1.6	1.6	-1.6
Weight adjusted by age	0.3	0.5	0.5	-0.7	-0.7	0.7
Bone surface	0.4	0.6	0.6	0.8	0.8	-0.8
Bone volume	0.9	1.6	1.6	1.3	1.3	-1.3
Breakpoint value in progressive ratio session	0.6	0.7	0.8	-0.9	-0.8	0.8
Number of licking bursts	0.4	0.6	0.6	0.8	0.8	-0.8
Context. condit. distance diff. score	4.4	5.4	5.4	2.3	2.3	-2.3
Locomotion velocity, session 1	1.6	1.7	1.7	-1.3	-1.3	1.3
Locomotion distance, session 1	0.2	0.2	0.2	-0.4	-0.4	0.4
Locomotion velocity, session 2	0.0	0.0	0.0	0.0	0.0	-0.0
Locomotion distance, session 2	0.0	0.0	0.0	-0.0	-0.0	0.0
Locomotion velocity, session 3	0.1	0.1	0.1	0.4	0.4	-0.4
Locomotion distance, session 3	0.1	0.1	0.1	0.3	0.3	-0.3
Stereotopy head waving bouts, day 3	0.1	0.1	0.1	-0.3	-0.3	0.3
Stereotopy head waving duration, day 3	0.2	0.3	0.3	0.5	0.5	-0.5
Locomotion velocity, session 7	0.0	0.0	0.0	0.2	0.2	-0.2
Locomotion distance, session 7	0.1	0.2	0.2	-0.4	-0.4	0.4
Stereotopy head waving bouts, day 7	0.0	0.0	0.0	-0.1	-0.1	0.1
Stereotopy head waving duration, day 7	0.0	0.0	0.0	-0.1	-0.1	0.1
Locomotion velocity, session 8	0.2	0.2	0.2	0.4	0.4	-0.4
Locomotion distance, session 8	2.7	3.9	3.9	2.0	2.0	-2.0
Degree of sensitization distance	0.4	0.4	0.4	-0.7	-0.7	0.7
Degree of sensitization stereotypy	0.1	0.1	0.1	-0.4	-0.4	0.4
Conditioned locomotion	6.1	7.0	7.0	-2.7	-2.6	2.6
Cocaine response after cond. corrected	4.1	4.9	4.9	-2.2	-2.2	2.2
Cocaine response after cond. not corrected	1.1	1.3	1.3	-1.2	-1.2	1.2
Cocaine response before conditioning	6.6	7.9	7.9	2.8	2.8	-2.8
Saline control response	0.0	0.1	0.1	0.3	0.3	-0.3
Bone: connectivity density	0.8	1.2	1.3	1.1	1.1	-1.1
Bone: cortical apparent density	0.1	0.1	0.1	0.4	0.4	-0.4
Bone: cortical area	0.6	1.0	1.0	1.0	1.0	-1.0
Bone: cortical porosity	0.3	0.3	0.3	-0.6	-0.6	0.6
Bone: cortical porosity	0.1	0.1	0.1	-0.4	-0.4	0.4
Bone: cortical thickness	0.1	0.1	0.1	0.3	0.3	-0.3
Bone: cortical thickness	1.2	1.4	1.4	-1.2	-1.2	1.2
Bone: cortical tissue density	0.1	0.1	0.1	0.3	0.3	-0.3
Condit. Reinf. active minus inactive responses	2.7	3.0	3.0	1.7	1.7	-1.7
Condit. Reinf. active-inactive response ratio	7.7	8.2	8.2	2.9	2.9	-2.9
Condit. Reinf. active responses	0.4	0.5	0.5	0.7	0.7	-0.7
Condit. Reinf. inactive responses	2.4	2.9	2.9	-1.7	-1.7	1.7
Incentive salience index mean	1.6	2.0	2.0	1.4	1.4	-1.4
Condit. Reinf. lever presses	0.3	0.4	0.4	0.7	0.7	-0.7
Condit. Reinf. active minus inactive responses	1.7	2.2	2.2	1.5	1.5	-1.5
Condit. Reinf. active-inactive response ratio	4.5	5.2	5.2	2.3	2.3	-2.3
Condit. Reinf. active responses	1.0	1.4	1.4	1.2	1.2	-1.2
Condit. Reinf. inactive responses	0.0	0.0	0.0	-0.2	-0.2	0.2
Condit. Reinf. lever presses	1.7	2.4	2.4	1.5	1.6	-1.6
Condit. Reinf. lever reinforcers received	1.2	1.6	1.6	1.3	1.3	-1.3
Conditioned reinforcement - actives	3.5	6.1	6.2	2.5	2.5	-2.5
Conditioned reinforcement - inactives	7.6	11.1	11.3	3.4	3.3	-3.3
Conditioned locomotion	3.6	4.7	4.7	2.2	2.2	-2.2
Patch foraging indifference point 0 sec	0.0	0.0	0.0	-0.0	-0.0	0.0
Patch foraging indifference point AUC	0.6	0.8	0.8	-0.9	-0.9	0.9
Delay disc. indifference point, 0s delay	0.0	0.0	0.0	-0.0	-0.0	0.0
Delay disc. indifference point, 16s delay	0.8	0.9	0.9	-0.9	-0.9	0.9
Delay disc. indifference point, 2s delay	0.0	0.0	0.0	0.1	0.1	-0.1
Delay disc. indifference point, 24s delay	0.6	0.6	0.6	-0.8	-0.8	0.8
Delay disc. indifference point, 4s delay	0.6	0.6	0.7	-0.8	-0.8	0.8
Delay disc. indifference point, 8s delay	0.1	0.1	0.1	-0.3	-0.3	0.3
Indifference point function ln k	0.3	0.6	0.6	0.7	0.7	-0.7
Indifference point function log k	0.3	0.6	0.6	0.7	0.7	-0.7
Patch foraging total patch changes 0 sec	0.0	0.0	0.0	0.0	0.0	-0.0
Patch foraging total patch changes 12 sec	0.2	0.3	0.3	0.5	0.5	-0.5
Patch foraging total patch changes 18 sec	0.0	0.0	0.0	-0.0	-0.0	0.0
Patch foraging total patch changes 24 sec	0.0	0.0	0.0	-0.1	-0.1	0.1
Patch foraging total patch changes 6 sec	0.0	0.0	0.0	-0.1	-0.1	0.1
Patch foraging time to switch 0 sec	0.4	0.8	0.8	0.9	0.9	-0.9
Patch foraging water rate 0 sec	0.0	0.0	0.0	-0.1	-0.1	0.1
Patch foraging water rate 12 sec	0.0	0.1	0.1	-0.3	-0.3	0.3
Patch foraging water rate 18 sec	0.2	0.4	0.4	0.6	0.6	-0.6
Patch foraging water rate 24 sec	0.0	0.0	0.0	0.1	0.1	-0.1
Patch foraging water rate 6 sec	0.1	0.1	0.2	-0.4	-0.4	0.4
Seeking ratio, delayed vs. immediate footshock	0.5	0.7	0.7	0.8	0.8	-0.8
Distance traveled before self-admin	0.0	0.1	0.1	0.2	0.2	-0.2
Distance traveled after self-admin	0.4	0.5	0.5	0.7	0.7	-0.7
Extensor digitorum longus weight	0.1	0.5	0.5	-0.7	-0.7	0.7
Bone: elastic displacement	0.5	0.5	0.5	-0.7	-0.7	0.7
Bone: elastic work	0.0	0.0	0.0	-0.0	-0.1	0.1
Bone: endosteal estimation	0.0	0.1	0.1	-0.3	-0.3	0.3
Bone: endosteal perimeter	0.2	0.4	0.4	0.6	0.7	-0.7
Epididymis fat weight	1.1	3.9	3.9	2.0	2.0	-2.0
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	-0.3	-0.3	0.3
Delta time in open arm before/after self-admin	0.2	0.2	0.2	-0.5	-0.5	0.5
Diff in mean of infusions in LGA sessions	0.1	0.2	0.2	-0.4	-0.4	0.4
Delay discount exponential model param	0.4	0.5	0.5	0.7	0.7	-0.7
Extinction: sum of active levers before priming	0.0	0.0	0.0	-0.2	-0.1	0.1
Active lever presses in extinction session 6	0.9	0.9	1.0	0.9	1.0	-1.0
Bone: final force	0.2	0.3	0.3	0.6	0.5	-0.5
Bone: final moment	0.1	0.2	0.2	0.4	0.4	-0.4
Food consumed during 24 hour testing period	3.5	4.8	4.8	2.2	2.2	-2.2
Glucose	2.1	3.3	3.3	1.8	1.8	-1.8
Heart weight	0.2	0.4	0.4	-0.6	-0.6	0.6
Delay discount hyperbolic model param	0.5	0.6	0.6	0.8	0.8	-0.8
Intermittent access intake day 1-15 change	0.5	0.9	1.0	1.0	1.0	-1.0
Intermittent access intake escalation	0.5	1.0	1.1	1.1	1.0	-1.0
Intermittent access intake escalation 2	0.5	0.6	0.7	0.8	0.8	-0.8
Intermitt. access day 1 inactive lever presses	0.7	2.8	2.9	1.7	1.7	-1.7
Intermitt. access day 15 inactive lever presses	1.1	2.2	2.3	1.5	1.5	-1.5
Intermitt. access escalation Index	0.6	0.9	0.9	-0.9	-0.9	0.9
Intermittent access day 1 total infusions	2.3	3.7	3.8	1.9	1.9	-1.9
Intermittent access day 15 total infusions	2.6	3.8	4.1	2.0	1.9	-1.9
Intermittent access terminal intake (last 3 days)	1.7	2.3	2.4	1.6	1.5	-1.5
Intermittent access total infusions	2.4	2.8	3.0	1.7	1.6	-1.6
Intermittent access day 1 locomotion	2.2	2.8	2.9	1.7	1.6	-1.6
Intermittent access day 15 total locomotion	0.3	0.5	0.5	0.7	0.7	-0.7
Intermittent access total locomotion	2.3	2.7	2.8	1.7	1.6	-1.6
Intermittent access standard deviation	1.5	3.0	3.2	1.8	1.7	-1.7
Left kidney weight	1.0	4.7	4.7	2.2	2.2	-2.2
Right kidney weight	1.6	7.2	7.2	2.7	2.7	-2.7
Cocaine induced anxiety	0.0	0.1	0.1	0.3	0.3	-0.3
Post-drug Anxiety	0.4	0.5	0.5	-0.7	-0.7	0.7
Baseline Anxiety	2.1	2.5	2.6	-1.6	-1.6	1.6
Tail length	0.4	1.4	1.4	1.2	1.2	-1.2
Length with tail	1.1	5.0	5.0	2.2	2.2	-2.2
Length without tail	1.2	3.8	3.8	2.0	1.9	-1.9
Times rat made contact with spout	0.3	0.4	0.4	0.6	0.6	-0.6
Lifetime Intake	1.9	2.3	2.5	1.6	1.5	-1.5
Liver weight, left	2.7	4.4	4.5	2.1	2.1	-2.1
Liver weight, right	1.7	2.9	2.9	1.7	1.7	-1.7
Locomotor activity	0.0	0.0	0.0	-0.2	-0.1	0.1
Locomotor testing distance	1.7	3.0	3.0	1.7	1.7	-1.7
Locomotor testing rearing	0.4	0.8	0.8	0.9	0.9	-0.9
Locomotion in novel chamber	0.6	0.7	0.7	0.8	0.8	-0.8
Locomotion in novel chamber post-restriction	0.7	1.1	1.1	-1.0	-1.0	1.0
Fecal boli incidents, locomotor time 1	3.4	4.9	5.0	-2.2	-2.2	2.2
Change in fecal boli incidents, locomotor task	2.0	2.0	2.0	1.4	1.4	-1.4
Time >=10cm from walls, locomotor time 1	0.7	0.8	0.8	-0.9	-0.9	0.9
Bouts of movement, locomotor time 1	0.1	0.1	0.1	-0.3	-0.3	0.3
Total resting periods, locomotor time 1	0.2	0.2	0.2	-0.5	-0.4	0.4
Rest time, locomotor task time 1	2.8	3.5	3.6	-1.9	-1.9	1.9
Distance moved, locomotor task time 1	1.4	2.0	2.1	1.5	1.4	-1.4
Vertical activity count, locomotor time 1	0.2	0.4	0.4	0.7	0.6	-0.6
Time >=10cm from walls, locomotor time 2	2.0	3.0	3.0	1.7	1.7	-1.7
Bouts of movement, locomotor time 2	1.1	1.7	1.7	1.3	1.3	-1.3
Total resting periods, locomotor time 2	1.0	1.8	1.8	1.3	1.3	-1.3
Rest time, locomotor task time 2	2.7	3.4	3.4	-1.8	-1.8	1.8
Distance moved, locomotor task time 2	2.4	2.8	2.8	1.7	1.7	-1.7
Vertical activity count, locomotor time 2	2.7	3.7	3.8	1.9	1.9	-1.9
Light reinforcement 1	0.0	0.1	0.1	0.3	0.3	-0.3
Light reinforcement 2	0.5	0.8	0.8	-0.9	-0.9	0.9
Bone: marrow area	0.0	0.1	0.1	-0.3	-0.3	0.3
Bone: maximum diameter	0.2	0.4	0.4	0.6	0.6	-0.6
Bone: maximum force	0.6	1.0	1.0	1.0	1.0	-1.0
Bone: maximum moment	0.3	0.6	0.6	0.8	0.7	-0.7
Mean time between licks in bursts	0.1	0.3	0.3	-0.6	-0.6	0.6
Mean num. licks in bursts	0.0	0.1	0.1	-0.3	-0.3	0.3
Cd content in liver	1.5	1.7	1.7	1.3	1.3	-1.3
Co content in liver	0.9	1.0	1.0	-1.0	-1.0	1.0
Cu content in liver	1.4	1.6	1.6	-1.3	-1.3	1.3
Fe content in liver	0.0	0.0	0.0	-0.1	-0.0	0.0
K content in liver	0.8	0.8	0.8	-0.9	-0.9	0.9
Mg content in liver	0.2	0.2	0.2	-0.4	-0.4	0.4
Mn content in liver	0.8	0.9	0.9	-1.0	-1.0	1.0
Na content in liver	1.5	1.6	1.6	1.2	1.3	-1.3
Rb content in liver	1.6	1.8	1.8	-1.3	-1.4	1.4
Se content in liver	4.2	4.9	4.9	-2.2	-2.2	2.2
Sr content in liver	0.0	0.0	0.0	-0.0	-0.0	0.0
Zn content in liver	0.0	0.0	0.0	-0.1	-0.1	0.1
Bone: minimum diameter	1.4	2.5	2.6	1.6	1.6	-1.6
Time in familiar zone, hab. session 1	1.2	1.2	1.2	-1.1	-1.1	1.1
Time in novel zone, hab. session 1	2.1	2.1	2.1	1.5	1.5	-1.5
Total zone transitions, hab. session 1	2.2	3.1	3.1	1.8	1.8	-1.8
Total locomotion distance, hab. session 1	0.5	0.8	0.8	0.9	0.9	-0.9
Locomotion velocity, hab. session 1	0.4	0.5	0.5	0.7	0.7	-0.7
Time in familiar zone, hab. session 2	0.2	0.2	0.2	-0.4	-0.4	0.4
Time in novel zone, hab. session 2	0.1	0.1	0.1	0.4	0.4	-0.4
Total zone transitions, hab. session 2	0.5	0.7	0.7	0.8	0.8	-0.8
Total locomotion distance, hab. session 2	0.4	0.5	0.5	-0.7	-0.7	0.7
Locomotion velocity, hab. session 2	0.2	0.3	0.3	-0.6	-0.6	0.6
Novel to familiar place preference ratio	3.2	3.5	3.5	1.9	1.9	-1.9
Novelty place preference	3.5	3.8	3.8	1.9	1.9	-1.9
Time in novel zone, NPP test	3.0	3.2	3.2	1.8	1.8	-1.8
Total zone transitions, NPP test	1.6	2.3	2.3	-1.5	-1.5	1.5
Total locomotion distance, NPP test	2.1	2.8	2.8	-1.7	-1.7	1.7
Locomotion velocity, NPP test	1.7	2.4	2.4	-1.6	-1.6	1.6
Intraocular pressure	0.2	0.3	0.3	-0.6	-0.6	0.6
Delta distance traveled before/after self-admin	0.0	0.0	0.0	0.1	0.1	-0.1
Delta ambulatory time before/after self-admin	0.2	0.2	0.2	0.5	0.5	-0.5
Parametrial fat weight	0.0	0.0	0.0	-0.2	-0.2	0.2
Pavlov. Cond. lever latency	0.5	0.6	0.6	-0.8	-0.8	0.8
Pavlov. Cond. magazine entry latency	1.0	1.3	1.3	1.2	1.2	-1.2
Pavlov. Cond. change in total contacts	0.0	0.0	0.0	-0.0	-0.0	0.0
Pavlov. Cond. index score	0.3	0.3	0.3	0.6	0.6	-0.6
Pavlov. Cond. latency score	0.4	0.4	0.5	0.7	0.7	-0.7
Pavlov. Cond. lever contacts	0.5	0.6	0.6	0.8	0.8	-0.8
Pavlov. Cond. magazine entry number	1.4	1.8	1.8	-1.3	-1.3	1.3
Pavlov. Cond. intertrial magazine entries	0.0	0.1	0.1	0.2	0.2	-0.2
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.2	0.5	0.5	-0.5
Pavlov. Cond. response bias	0.9	1.1	1.1	1.0	1.0	-1.0
Pavlov. Cond. lever latency	1.9	2.6	2.6	-1.6	-1.6	1.6
Pavlov. Cond. magazine entry latency	1.2	1.5	1.5	1.2	1.2	-1.2
Pavlov. Cond. change in total contacts	0.4	0.7	0.7	0.8	0.8	-0.8
Pavlov. Cond. index score	2.3	3.0	3.1	1.7	1.7	-1.7
Pavlov. Cond. latency score	2.1	2.7	2.7	1.6	1.7	-1.7
Pavlov. Cond. lever contacts	2.9	4.0	4.0	2.0	2.0	-2.0
Pavlov. Cond. magazine entry number	1.4	1.7	1.7	-1.3	-1.3	1.3
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.0	-0.1	-0.1	0.1
Pavlov. Cond. lever-magazine prob. diff.	2.0	2.6	2.6	1.6	1.6	-1.6
Pavlov. Cond. response bias	3.0	4.1	4.1	2.0	2.0	-2.0
Time in closed arm before self-admin	5.8	7.5	7.5	2.7	2.7	-2.7
Time in closed arm after self-admin	4.0	4.3	4.3	2.1	2.1	-2.1
Time in open arm before self-admin	4.3	4.7	4.9	-2.2	-2.2	2.2
Time in open arm after self-admin	6.5	7.1	7.1	-2.7	-2.7	2.7
Bone: periosteal estimation	0.0	0.0	0.0	0.2	0.2	-0.2
Bone: periosteal perimeter	0.6	1.0	1.0	1.0	1.0	-1.0
Bone: post-yield work	0.0	0.0	0.0	0.2	0.2	-0.2
Progressive ratio test 1 active lever presses	1.3	1.7	1.8	1.3	1.3	-1.3
Progressive ratio test 1 breakpoint	1.3	1.5	1.6	1.3	1.2	-1.2
Progressive ratio test 1 inactive lever presses	1.6	2.2	2.4	1.5	1.5	-1.5
Progressive ratio test 2 active lever presses	4.4	5.2	5.4	2.3	2.3	-2.3
Progressive ratio test 2 breakpoint	4.4	5.0	5.2	2.3	2.2	-2.2
Progressive ratio test 2 inactive lever presses	4.3	6.9	7.1	2.7	2.6	-2.6
Incentive Sensitization - Responses	2.4	3.3	3.3	1.8	1.8	-1.8
Incentive Sensitization - Breakpoint	2.5	3.3	3.3	1.8	1.8	-1.8
Sum of active levers in priming session hrs 5-6	3.0	2.8	2.8	-1.7	-1.7	1.7
Progressive ratio	0.9	1.4	1.4	1.1	1.2	-1.2
Food seeking constrained by brief footshock	0.2	0.2	0.2	0.4	0.4	-0.4
Seeking ratio, punishment vs. effort	0.4	0.6	0.6	-0.7	-0.8	0.8
Retroperitoneal fat weight	19.1	81.5	81.6	9.0	9.0	-9.0
Reaction time number correct	0.3	0.6	0.6	-0.8	-0.8	0.8
Reaction time mean minus median	0.0	0.1	0.1	-0.3	-0.3	0.3
Reaction time mean minus median AUC	0.0	0.0	0.0	-0.2	-0.2	0.2
Reaction time num false alarms	2.1	3.0	3.0	-1.7	-1.7	1.7
Reaction time num false alarms AUC	2.8	4.4	4.5	-2.1	-2.1	2.1
Reaction time trials correct on left	0.3	0.6	0.6	-0.8	-0.8	0.8
Reaction time trials on left	0.4	0.7	0.7	-0.8	-0.8	0.8
Reaction time mean	0.2	0.3	0.3	0.6	0.6	-0.6
Reaction time mean AUC	0.3	0.5	0.5	0.7	0.7	-0.7
Median of all reaction times	0.5	0.7	0.7	0.8	0.8	-0.8
Reaction time omissions	0.2	0.4	0.4	-0.6	-0.6	0.6
Reaction time false alarm rate	2.1	3.0	3.0	-1.7	-1.7	1.7
Reaction time premature initiation rate	0.0	0.0	0.0	-0.2	-0.2	0.2
Reaction time premature initiations	0.2	0.4	0.5	-0.7	-0.7	0.7
Std. dev. reaction times	0.0	0.0	0.0	0.0	0.0	-0.0
Reaction time trials completed	0.4	0.7	0.7	-0.8	-0.8	0.8
Reaction time trials AUC	0.2	0.4	0.4	-0.6	-0.7	0.7
Run reversals in cocaine runway, females	2.0	2.0	2.0	1.4	1.4	-1.4
Run reversals in cocaine runway, males	0.0	0.0	0.0	-0.2	-0.2	0.2
Latency to leave start box in cocaine runway	0.5	0.6	0.6	-0.8	-0.7	0.7
Latency to leave start box in cocaine runway, F	0.5	0.6	0.6	-0.8	-0.7	0.7
Latency to leave start box in cocaine runway, M	0.0	0.0	0.0	0.1	0.1	-0.1
Std. dev. time between licks in bursts	0.6	0.8	0.8	0.9	0.9	-0.9
Total sessions with >9 infusions	0.8	1.0	1.0	1.0	1.0	-1.0
Short access day 1 total inactive lever presses	1.2	1.6	1.6	1.3	1.2	-1.2
Short access day 10 total inactive lever presses	0.1	0.3	0.3	0.6	0.6	-0.6
Short access day 1 total infusions	2.2	2.9	3.0	1.7	1.7	-1.7
Short access day 10 total infusions	1.0	1.3	1.4	1.2	1.1	-1.1
Short access total infusions	0.8	1.0	1.1	1.1	1.0	-1.0
Short access day 1 locomotion	1.0	1.2	1.3	1.1	1.1	-1.1
Short access day 10 total locomotion	1.4	2.6	2.7	1.6	1.6	-1.6
Short access total locomotion	1.2	1.4	1.5	1.2	1.2	-1.2
One hour access (0.3 mA shock)	3.6	4.1	4.3	2.1	2.0	-2.0
Compulsive drug intake	3.8	4.5	4.5	-2.1	-2.1	2.1
One hour access (shock baseline)	4.7	7.2	7.4	2.7	2.7	-2.7
Social response proportion	4.0	4.5	4.5	-2.1	-2.1	2.1
Social responses	0.5	0.6	0.7	-0.8	-0.8	0.8
Social time	6.3	8.5	8.5	-2.9	-2.9	2.9
Soleus weight	0.2	0.5	0.5	-0.7	-0.7	0.7
Bone: stiffness	1.0	1.6	1.6	1.3	1.3	-1.3
Tibialis anterior weight	1.6	5.3	5.3	-2.3	-2.3	2.3
Time to tail flick, vehicle, before self-admin	0.4	0.5	0.5	0.7	0.7	-0.7
Time to tail flick, vehicle, after self-admin	3.6	4.7	4.7	2.2	2.2	-2.2
Time to tail flick, test, before self-admin	2.0	2.1	2.1	1.4	1.5	-1.5
Time to tail flick, test, after self-admin	3.5	3.7	3.7	1.9	1.9	-1.9
Delta time to tail flick, vehicle, before/after SA	1.4	1.3	1.3	1.2	1.2	-1.2
Delta time to tail flick, test, before/after SA	0.1	0.1	0.1	-0.4	-0.4	0.4
Tibia length	0.2	0.5	0.5	-0.7	-0.7	0.7
Ambulatory time before self-admin	0.0	0.0	0.0	0.1	0.2	-0.2
Ambulatory time after self-admin	0.7	0.9	0.9	0.9	0.9	-0.9
Bone: tissue strength	0.4	0.4	0.4	-0.6	-0.6	0.6
Total heroin consumption	0.2	0.2	0.3	-0.5	-0.5	0.5
Bone: trabecular number	0.7	1.1	1.1	1.0	1.1	-1.1
Bone: trabecular spacing	0.0	0.0	0.0	-0.0	-0.0	0.0
Bone: trabecular thickness	0.5	0.7	0.7	0.8	0.8	-0.8
Bone: trabecular tissue density	0.3	0.4	0.4	-0.6	-0.6	0.6
Water consumed over 24 hours	1.1	1.4	1.4	1.2	1.2	-1.2
Number of responses in last shaping day	4.7	5.1	5.3	2.3	2.2	-2.2