Hub : Genes

Wt1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Wt1	0.13	0.19	2.0e-08	0.06	0.05	0.06	0.06	2.0e-07	1.9e-06	6.0e-07	2.8e-07
2	Liver	intron excision ratio	chr3_91607414_91609445	0.02	0.02	5.2e-03	0.02	0.01	0.01	0.01	5.8e-03	1.1e-02	7.3e-03	6.9e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Bone: apparent density	0.6	1.0	1.1	-1.1	0.9
Area under the delay curve	0.4	0.4	0.5	0.6	-0.7
BMI with tail	0.3	1.0	1.1	-1.0	1.0
BMI without tail	0.3	0.5	0.6	-0.8	0.6
Body weight	0.9	3.9	4.0	-1.9	2.0
Weight adjusted by age	0.0	0.0	0.0	-0.1	-0.1
Bone surface	0.3	0.6	0.7	-0.8	0.7
Bone volume	0.8	1.3	1.4	-1.2	1.1
Breakpoint value in progressive ratio session	1.3	1.4	1.6	1.1	-1.3
Number of licking bursts	0.4	0.5	0.5	-0.7	0.7
Context. condit. distance diff. score	4.5	5.4	5.5	-2.3	2.3
Locomotion velocity, session 1	2.0	2.1	2.1	1.4	-1.5
Locomotion distance, session 1	0.2	0.2	0.2	0.5	-0.5
Locomotion velocity, session 2	0.0	0.0	0.0	0.1	-0.0
Locomotion distance, session 2	0.0	0.0	0.0	0.1	-0.2
Locomotion velocity, session 3	0.1	0.1	0.2	-0.4	0.3
Locomotion distance, session 3	0.1	0.1	0.1	-0.3	0.3
Stereotopy head waving bouts, day 3	0.1	0.1	0.2	0.3	-0.4
Stereotopy head waving duration, day 3	0.2	0.3	0.3	-0.6	0.5
Locomotion velocity, session 7	0.1	0.1	0.1	-0.2	0.3
Locomotion distance, session 7	0.2	0.2	0.2	0.5	-0.4
Stereotopy head waving bouts, day 7	0.0	0.0	0.0	-0.2	0.0
Stereotopy head waving duration, day 7	0.0	0.0	0.0	0.0	-0.2
Locomotion velocity, session 8	0.1	0.2	0.2	-0.3	0.4
Locomotion distance, session 8	2.6	3.8	3.9	-2.0	1.9
Degree of sensitization distance	0.4	0.4	0.5	0.7	-0.6
Degree of sensitization stereotypy	0.2	0.2	0.2	0.3	-0.5
Conditioned locomotion	5.6	6.6	6.8	2.6	-2.5
Cocaine response after cond. corrected	3.8	4.3	4.3	2.1	-2.1
Cocaine response after cond. not corrected	1.0	1.1	1.1	1.0	-1.1
Cocaine response before conditioning	6.3	7.6	8.0	-2.8	2.7
Saline control response	0.1	0.1	0.2	-0.3	0.4
Bone: connectivity density	0.7	1.1	1.3	-1.2	0.9
Bone: cortical apparent density	0.0	0.0	0.0	-0.1	0.0
Bone: cortical area	0.5	0.8	0.9	-0.9	0.9
Bone: cortical porosity	0.7	0.8	0.9	0.9	-0.8
Bone: cortical porosity	0.1	0.1	0.2	0.4	-0.4
Bone: cortical thickness	0.0	0.0	0.0	-0.2	0.2
Bone: cortical thickness	1.1	1.3	1.5	1.1	-1.2
Bone: cortical tissue density	0.0	0.0	0.0	-0.1	0.1
Condit. Reinf. active minus inactive responses	2.5	2.8	3.0	-1.7	1.6
Condit. Reinf. active-inactive response ratio	6.9	7.5	7.8	-2.8	2.7
Condit. Reinf. active responses	0.4	0.4	0.5	-0.7	0.6
Condit. Reinf. inactive responses	2.4	2.8	2.8	1.7	-1.7
Incentive salience index mean	1.5	1.9	2.0	-1.4	1.3
Condit. Reinf. lever presses	0.4	0.6	0.6	-0.7	0.8
Condit. Reinf. active minus inactive responses	2.2	2.8	2.9	-1.6	1.7
Condit. Reinf. active-inactive response ratio	5.6	5.8	6.0	-2.4	2.5
Condit. Reinf. active responses	1.4	2.0	2.1	-1.4	1.5
Condit. Reinf. inactive responses	0.0	0.0	0.0	-0.0	-0.0
Condit. Reinf. lever presses	1.5	2.0	2.1	-1.4	1.4
Condit. Reinf. lever reinforcers received	1.6	2.2	2.3	-1.4	1.5
Conditioned reinforcement - actives	8.5	8.5	8.7	-2.9	3.0
Conditioned reinforcement - inactives	16.1	18.1	18.3	-4.3	4.2
Conditioned locomotion	5.5	6.6	6.7	-2.6	2.6
Patch foraging indifference point 0 sec	0.0	0.0	0.0	0.0	0.1
Patch foraging indifference point AUC	1.3	1.5	1.6	1.2	-1.3
Delay disc. indifference point, 0s delay	0.0	0.0	0.0	-0.1	0.1
Delay disc. indifference point, 16s delay	0.8	0.8	0.8	0.9	-0.9
Delay disc. indifference point, 2s delay	0.1	0.1	0.2	-0.4	0.3
Delay disc. indifference point, 24s delay	0.6	0.6	0.7	0.8	-0.7
Delay disc. indifference point, 4s delay	0.4	0.4	0.5	0.6	-0.7
Delay disc. indifference point, 8s delay	0.0	0.0	0.0	-0.0	-0.2
Indifference point function ln k	0.6	0.8	1.0	-0.8	1.0
Indifference point function log k	0.6	0.8	1.0	-0.8	1.0
Patch foraging total patch changes 0 sec	0.0	0.0	0.0	0.0	0.1
Patch foraging total patch changes 12 sec	0.3	0.4	0.5	-0.5	0.7
Patch foraging total patch changes 18 sec	0.0	0.0	0.0	-0.0	-0.1
Patch foraging total patch changes 24 sec	0.0	0.0	0.0	0.1	0.0
Patch foraging total patch changes 6 sec	0.0	0.0	0.0	0.1	-0.0
Patch foraging time to switch 0 sec	0.6	0.9	0.9	-1.0	0.9
Patch foraging water rate 0 sec	0.0	0.0	0.0	0.2	-0.1
Patch foraging water rate 12 sec	0.0	0.0	0.1	0.2	-0.2
Patch foraging water rate 18 sec	0.3	0.5	0.5	-0.7	0.7
Patch foraging water rate 24 sec	0.0	0.0	0.0	-0.2	0.2
Patch foraging water rate 6 sec	0.0	0.0	0.1	0.1	-0.3
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.2	-0.4	0.4
Distance traveled before self-admin	0.3	0.3	0.3	-0.5	0.5
Distance traveled after self-admin	1.5	1.7	2.5	-1.0	1.6
Extensor digitorum longus weight	0.2	0.7	0.9	0.9	-0.7
Bone: elastic displacement	0.7	0.8	0.8	0.9	-0.9
Bone: elastic work	0.0	0.0	0.0	0.1	0.0
Bone: endosteal estimation	0.0	0.1	0.1	0.3	-0.2
Bone: endosteal perimeter	0.2	0.5	0.6	-0.6	0.7
Epididymis fat weight	1.6	3.6	3.8	-1.9	2.0
Delta time in closed arm before/after self-admin	0.0	0.0	0.0	0.1	-0.1
Delta time in open arm before/after self-admin	1.7	1.6	2.0	1.1	-1.4
Diff in mean of infusions in LGA sessions	0.1	0.1	0.2	-0.2	-0.4
Delay discount exponential model param	0.5	0.5	0.6	-0.6	0.8
Extinction: sum of active levers before priming	0.0	0.0	0.0	-0.1	0.1
Active lever presses in extinction session 6	1.0	0.9	1.3	-0.8	1.1
Bone: final force	0.1	0.2	0.4	-0.4	0.6
Bone: final moment	0.0	0.1	0.1	-0.1	0.4
Food consumed during 24 hour testing period	3.8	4.6	4.8	-2.2	2.1
Glucose	1.1	1.7	1.8	-1.3	1.3
Heart weight	0.4	0.6	0.6	0.8	-0.7
Delay discount hyperbolic model param	0.3	0.3	0.4	-0.5	0.7
Intermittent access intake day 1-15 change	0.9	0.9	1.0	-1.0	0.9
Intermittent access intake escalation	1.0	1.0	1.1	-1.0	0.9
Intermittent access intake escalation 2	1.1	1.1	1.1	-1.1	1.1
Intermitt. access day 1 inactive lever presses	3.6	3.8	4.0	-1.9	2.0
Intermitt. access day 15 inactive lever presses	5.2	5.7	5.9	-2.4	2.4
Intermitt. access escalation Index	0.6	0.5	0.5	0.7	-0.7
Intermittent access day 1 total infusions	3.2	3.7	3.8	-2.0	1.9
Intermittent access day 15 total infusions	5.1	5.7	5.9	-2.4	2.3
Intermittent access terminal intake (last 3 days)	5.0	5.5	5.7	-2.3	2.4
Intermittent access total infusions	5.2	5.8	5.9	-2.4	2.4
Intermittent access day 1 locomotion	2.6	2.7	2.8	-1.7	1.6
Intermittent access day 15 total locomotion	1.4	1.5	1.6	-1.2	1.3
Intermittent access total locomotion	3.5	3.9	4.1	-2.0	2.0
Intermittent access standard deviation	2.8	3.0	3.0	-1.7	1.7
Left kidney weight	1.0	2.8	3.0	-1.6	1.7
Right kidney weight	0.9	2.5	2.9	-1.5	1.7
Cocaine induced anxiety	2.7	3.1	3.1	-1.8	1.8
Post-drug Anxiety	0.5	0.5	0.6	-0.7	0.8
Baseline Anxiety	5.5	5.9	6.0	2.4	-2.4
Tail length	0.1	0.2	0.3	-0.5	0.4
Length with tail	0.4	1.4	1.5	-1.2	1.2
Length without tail	0.8	1.8	2.0	-1.3	1.4
Times rat made contact with spout	0.3	0.3	0.3	-0.5	0.6
Lifetime Intake	4.8	5.5	5.6	-2.4	2.3
Liver weight, left	0.8	1.3	1.3	-1.2	1.1
Liver weight, right	2.7	4.4	4.5	-2.1	2.1
Locomotor activity	0.0	0.0	0.0	0.1	0.1
Locomotor testing distance	1.6	2.6	3.0	-1.5	1.7
Locomotor testing rearing	0.6	0.9	0.9	-1.0	0.9
Locomotion in novel chamber	0.4	0.6	0.6	-0.7	0.8
Locomotion in novel chamber post-restriction	1.5	1.9	2.0	1.4	-1.3
Fecal boli incidents, locomotor time 1	7.1	7.8	7.8	2.8	-2.8
Change in fecal boli incidents, locomotor task	2.1	2.0	2.1	-1.5	1.4
Time >=10cm from walls, locomotor time 1	1.1	1.1	1.1	1.0	-1.1
Bouts of movement, locomotor time 1	0.1	0.1	0.1	0.1	-0.4
Total resting periods, locomotor time 1	0.3	0.3	0.4	0.4	-0.6
Rest time, locomotor task time 1	2.8	3.0	3.4	1.7	-1.8
Distance moved, locomotor task time 1	2.6	2.9	3.3	-1.6	1.8
Vertical activity count, locomotor time 1	0.6	0.7	0.8	-0.7	0.9
Time >=10cm from walls, locomotor time 2	2.7	2.9	2.9	-1.7	1.7
Bouts of movement, locomotor time 2	1.9	2.0	2.2	-1.5	1.4
Total resting periods, locomotor time 2	1.8	1.9	2.1	-1.4	1.3
Rest time, locomotor task time 2	3.6	4.1	4.4	2.0	-2.1
Distance moved, locomotor task time 2	2.8	3.3	3.6	-1.7	1.9
Vertical activity count, locomotor time 2	3.6	4.0	4.2	-1.9	2.0
Light reinforcement 1	0.1	0.1	0.2	-0.2	0.5
Light reinforcement 2	0.8	1.0	1.2	1.1	-0.9
Bone: marrow area	0.0	0.1	0.1	0.3	-0.2
Bone: maximum diameter	0.2	0.4	0.4	-0.6	0.7
Bone: maximum force	0.4	0.6	0.9	-0.7	0.9
Bone: maximum moment	0.1	0.2	0.4	-0.3	0.6
Mean time between licks in bursts	0.2	0.2	0.2	0.4	-0.5
Mean num. licks in bursts	0.1	0.1	0.1	0.3	-0.2
Cd content in liver	0.1	0.2	0.2	-0.4	0.4
Co content in liver	1.6	1.9	1.9	1.3	-1.4
Cu content in liver	1.2	1.4	1.5	1.2	-1.1
Fe content in liver	0.2	0.2	0.2	0.4	-0.5
K content in liver	0.7	0.7	0.7	0.8	-0.8
Mg content in liver	0.7	0.7	0.7	0.8	-0.8
Mn content in liver	1.4	1.6	1.6	1.3	-1.3
Na content in liver	0.2	0.2	0.2	-0.5	0.5
Rb content in liver	1.1	1.4	1.4	1.2	-1.2
Se content in liver	3.6	4.5	4.5	2.1	-2.1
Sr content in liver	0.0	0.0	0.0	-0.1	0.1
Zn content in liver	1.4	1.6	1.6	1.2	-1.3
Bone: minimum diameter	1.2	2.3	2.6	-1.4	1.6
Time in familiar zone, hab. session 1	1.3	1.2	1.3	1.1	-1.1
Time in novel zone, hab. session 1	2.2	2.1	2.2	-1.5	1.4
Total zone transitions, hab. session 1	1.9	2.7	2.8	-1.7	1.6
Total locomotion distance, hab. session 1	0.5	0.6	0.7	-0.8	0.8
Locomotion velocity, hab. session 1	0.3	0.5	0.5	-0.7	0.6
Time in familiar zone, hab. session 2	0.3	0.3	0.3	0.6	-0.5
Time in novel zone, hab. session 2	0.2	0.2	0.2	-0.5	0.4
Total zone transitions, hab. session 2	0.4	0.6	0.6	-0.8	0.7
Total locomotion distance, hab. session 2	0.4	0.5	0.6	0.7	-0.7
Locomotion velocity, hab. session 2	0.3	0.4	0.4	0.6	-0.6
Novel to familiar place preference ratio	3.6	3.7	3.7	-1.9	1.9
Novelty place preference	3.9	3.9	3.9	-2.0	2.0
Time in novel zone, NPP test	3.2	3.2	3.3	-1.8	1.8
Total zone transitions, NPP test	1.7	2.5	2.6	1.5	-1.6
Total locomotion distance, NPP test	2.2	3.0	3.2	1.7	-1.8
Locomotion velocity, NPP test	1.9	2.7	2.8	1.6	-1.7
Intraocular pressure	0.3	0.4	0.5	0.6	-0.7
Delta distance traveled before/after self-admin	0.2	0.2	0.4	-0.1	0.6
Delta ambulatory time before/after self-admin	0.4	0.4	0.6	-0.4	0.8
Parametrial fat weight	0.1	0.2	0.2	-0.5	0.4
Pavlov. Cond. lever latency	0.4	0.5	0.6	0.8	-0.6
Pavlov. Cond. magazine entry latency	1.1	1.5	1.6	-1.2	1.2
Pavlov. Cond. change in total contacts	0.0	0.0	0.0	0.1	-0.2
Pavlov. Cond. index score	0.2	0.2	0.3	-0.5	0.4
Pavlov. Cond. latency score	0.2	0.3	0.4	-0.6	0.5
Pavlov. Cond. lever contacts	0.2	0.3	0.3	-0.6	0.4
Pavlov. Cond. magazine entry number	1.3	1.6	1.7	1.3	-1.2
Pavlov. Cond. intertrial magazine entries	0.0	0.1	0.1	-0.2	0.3
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.1	-0.3	0.2
Pavlov. Cond. response bias	0.6	0.7	0.8	-0.9	0.8
Pavlov. Cond. lever latency	2.0	2.7	3.1	1.8	-1.5
Pavlov. Cond. magazine entry latency	1.2	1.4	1.6	-1.3	1.1
Pavlov. Cond. change in total contacts	0.4	0.6	0.7	-0.8	0.6
Pavlov. Cond. index score	1.9	2.5	2.8	-1.7	1.5
Pavlov. Cond. latency score	1.9	2.3	2.6	-1.6	1.4
Pavlov. Cond. lever contacts	2.7	3.7	4.2	-2.0	1.8
Pavlov. Cond. magazine entry number	1.0	1.2	1.3	1.1	-1.0
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.0	-0.0	0.2
Pavlov. Cond. lever-magazine prob. diff.	1.8	2.2	2.5	-1.6	1.4
Pavlov. Cond. response bias	2.7	3.7	4.1	-2.0	1.8
Time in closed arm before self-admin	4.0	4.6	4.7	-2.1	2.2
Time in closed arm after self-admin	2.9	2.9	3.0	-1.7	1.7
Time in open arm before self-admin	3.1	3.4	3.5	1.9	-1.8
Time in open arm after self-admin	7.0	7.7	7.7	2.8	-2.8
Bone: periosteal estimation	0.0	0.1	0.1	-0.2	0.3
Bone: periosteal perimeter	0.5	0.9	1.0	-0.9	1.0
Bone: post-yield work	0.0	0.0	0.0	0.1	-0.1
Progressive ratio test 1 active lever presses	2.9	3.0	3.2	-1.8	1.7
Progressive ratio test 1 breakpoint	2.5	2.6	2.8	-1.7	1.6
Progressive ratio test 1 inactive lever presses	3.9	4.2	4.5	-2.1	2.0
Progressive ratio test 2 active lever presses	4.1	4.4	4.4	-2.1	2.1
Progressive ratio test 2 breakpoint	4.8	5.4	5.4	-2.3	2.3
Progressive ratio test 2 inactive lever presses	8.3	9.6	9.8	-3.1	3.1
Incentive Sensitization - Responses	1.7	1.7	1.7	-1.3	1.3
Incentive Sensitization - Breakpoint	1.5	1.5	1.6	-1.2	1.3
Sum of active levers in priming session hrs 5-6	1.3	1.3	1.4	1.2	-1.1
Progressive ratio	0.3	0.3	0.5	-0.7	0.4
Food seeking constrained by brief footshock	0.3	0.3	0.5	-0.7	0.5
Seeking ratio, punishment vs. effort	0.2	0.3	0.4	0.6	-0.4
Retroperitoneal fat weight	15.6	51.4	51.4	-7.2	7.2
Reaction time number correct	0.2	0.3	0.3	0.5	-0.5
Reaction time mean minus median	0.1	0.1	0.1	0.3	-0.3
Reaction time mean minus median AUC	0.1	0.1	0.1	0.2	-0.3
Reaction time num false alarms	2.3	3.2	3.7	1.9	-1.6
Reaction time num false alarms AUC	3.5	4.9	5.5	2.4	-2.0
Reaction time trials correct on left	0.2	0.3	0.3	0.5	-0.5
Reaction time trials on left	0.2	0.3	0.3	0.6	-0.6
Reaction time mean	0.1	0.2	0.2	-0.5	0.3
Reaction time mean AUC	0.2	0.3	0.3	-0.6	0.4
Median of all reaction times	0.3	0.5	0.5	-0.7	0.6
Reaction time omissions	0.3	0.4	0.4	0.6	-0.6
Reaction time false alarm rate	2.8	3.9	4.4	2.1	-1.8
Reaction time premature initiation rate	0.0	0.0	0.0	0.0	0.1
Reaction time premature initiations	0.1	0.1	0.1	0.4	-0.2
Std. dev. reaction times	0.0	0.0	0.0	0.0	-0.2
Reaction time trials completed	0.2	0.3	0.3	0.6	-0.6
Reaction time trials AUC	0.1	0.2	0.2	0.4	-0.4
Run reversals in cocaine runway, females	1.4	1.3	1.4	-1.2	1.1
Run reversals in cocaine runway, males	0.0	0.0	0.0	0.2	-0.2
Latency to leave start box in cocaine runway	0.4	0.4	0.5	0.7	-0.5
Latency to leave start box in cocaine runway, F	0.4	0.4	0.5	0.7	-0.6
Latency to leave start box in cocaine runway, M	0.0	0.0	0.0	0.1	-0.0
Std. dev. time between licks in bursts	0.7	0.8	1.0	-1.0	0.8
Total sessions with >9 infusions	2.4	2.6	2.7	-1.6	1.6
Short access day 1 total inactive lever presses	1.1	1.3	1.3	-1.1	1.1
Short access day 10 total inactive lever presses	0.5	0.5	0.6	-0.8	0.7
Short access day 1 total infusions	5.8	6.2	6.3	-2.5	2.5
Short access day 10 total infusions	1.8	2.0	2.2	-1.5	1.4
Short access total infusions	2.7	3.1	3.1	-1.8	1.7
Short access day 1 locomotion	0.5	0.6	0.6	-0.7	0.7
Short access day 10 total locomotion	2.3	2.6	2.8	-1.5	1.7
Short access total locomotion	1.4	1.5	1.7	-1.2	1.3
One hour access (0.3 mA shock)	4.1	4.8	4.9	-2.2	2.2
Compulsive drug intake	2.5	2.5	2.5	1.6	-1.6
One hour access (shock baseline)	6.8	7.8	7.9	-2.8	2.8
Social response proportion	4.4	4.7	4.8	2.2	-2.2
Social responses	0.5	0.6	0.7	0.8	-0.8
Social time	7.5	9.9	9.9	3.2	-3.1
Soleus weight	0.4	1.1	1.2	1.0	-1.1
Bone: stiffness	0.8	1.3	1.5	-1.0	1.2
Tibialis anterior weight	1.7	5.8	6.0	2.5	-2.4
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.3	-0.6	0.5
Time to tail flick, vehicle, after self-admin	3.6	3.8	4.2	-2.0	1.9
Time to tail flick, test, before self-admin	0.3	0.3	0.4	-0.6	0.4
Time to tail flick, test, after self-admin	0.7	0.7	1.1	-1.0	0.7
Delta time to tail flick, vehicle, before/after SA	1.6	1.6	1.6	-1.3	1.3
Delta time to tail flick, test, before/after SA	0.3	0.3	0.3	0.5	-0.6
Tibia length	0.1	0.3	0.4	0.6	-0.4
Ambulatory time before self-admin	0.3	0.3	0.3	-0.5	0.5
Ambulatory time after self-admin	2.1	2.3	2.8	-1.3	1.7
Bone: tissue strength	0.5	0.5	0.6	0.8	-0.7
Total heroin consumption	0.4	0.4	0.5	0.7	-0.6
Bone: trabecular number	0.6	1.0	1.2	-1.1	0.9
Bone: trabecular spacing	0.0	0.0	0.1	-0.1	0.2
Bone: trabecular thickness	0.1	0.2	0.2	-0.4	0.4
Bone: trabecular tissue density	0.8	1.1	1.1	1.0	-1.1
Water consumed over 24 hours	0.5	0.6	0.7	-0.8	0.7
Number of responses in last shaping day	2.2	2.3	2.4	-1.5	1.5