Myo7a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Myo7a	0.16	0.09	6.0e-06	0.05	0.04	0.04	0.04	7.3e-06	1.1e-05	5.2e-05	1.5e-05
2	Eye	alternative polyA	NM_153473.2	0.46	0.16	1.2e-03	0.11	0.06	0.06	0.11	8.9e-03	4.1e-02	4.7e-02	9.9e-03
3	Eye	alternative polyA	XM_006229744.4	0.48	0.18	2.2e-03	0.11	0.06	0.08	0.09	8.9e-03	3.9e-02	2.6e-02	1.5e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3
Bone: apparent density	0.0	0.1	0.1	-0.2	-0.2	0.2
Area under the delay curve	1.1	1.2	1.7	0.4	-1.3	1.3
BMI with tail	1.7	5.4	6.7	-1.7	2.6	-2.6
BMI without tail	8.2	17.0	22.4	-2.5	4.7	-4.7
Body weight	2.8	11.9	15.4	-2.2	3.9	-3.9
Weight adjusted by age	0.3	0.4	0.6	-0.8	0.5	-0.5
Bone surface	0.6	1.0	1.2	0.8	-1.1	1.1
Bone volume	0.1	0.2	0.4	0.2	-0.6	0.6
Breakpoint value in progressive ratio session	0.0	0.0	0.0	-0.1	-0.1	0.1
Number of licking bursts	3.2	3.8	6.1	-2.5	1.6	-1.6
Context. condit. distance diff. score	2.0	2.4	2.8	1.2	-1.7	1.7
Locomotion velocity, session 1	1.2	1.3	1.6	0.9	-1.3	1.3
Locomotion distance, session 1	0.6	0.7	1.4	1.2	-0.6	0.6
Locomotion velocity, session 2	0.7	0.9	1.0	0.7	-1.0	1.0
Locomotion distance, session 2	0.1	0.2	0.6	0.8	0.0	-0.0
Locomotion velocity, session 3	0.3	0.3	0.4	0.6	-0.5	0.5
Locomotion distance, session 3	2.0	2.2	2.6	1.2	-1.6	1.6
Stereotopy head waving bouts, day 3	1.4	1.7	2.3	-0.5	1.5	-1.5
Stereotopy head waving duration, day 3	0.2	0.2	0.7	0.8	-0.0	0.0
Locomotion velocity, session 7	0.3	0.3	0.3	-0.5	-0.6	0.6
Locomotion distance, session 7	0.2	0.2	0.4	-0.6	-0.4	0.4
Stereotopy head waving bouts, day 7	1.2	1.3	2.9	1.7	-0.7	0.7
Stereotopy head waving duration, day 7	1.3	1.6	3.3	1.8	-0.8	0.8
Locomotion velocity, session 8	5.3	6.3	8.2	1.6	-2.9	2.9
Locomotion distance, session 8	1.3	1.9	2.4	1.5	-1.3	1.3
Degree of sensitization distance	2.1	2.1	2.2	-1.4	1.5	-1.5
Degree of sensitization stereotypy	4.2	4.6	6.5	2.6	-1.9	1.9
Conditioned locomotion	0.3	0.3	0.4	0.4	-0.7	0.7
Cocaine response after cond. corrected	0.5	0.6	1.8	-1.3	-0.1	0.1
Cocaine response after cond. not corrected	0.1	0.2	0.2	-0.5	-0.4	0.4
Cocaine response before conditioning	0.8	1.0	2.7	1.7	-0.3	0.3
Saline control response	0.4	0.5	1.2	1.1	0.4	-0.4
Bone: connectivity density	0.6	0.9	1.2	0.7	-1.1	1.1
Bone: cortical apparent density	0.7	0.9	1.1	-1.0	0.9	-0.9
Bone: cortical area	0.3	0.5	0.6	-0.6	0.8	-0.8
Bone: cortical porosity	1.1	1.2	2.3	1.5	-0.8	0.8
Bone: cortical porosity	1.0	1.0	2.2	1.5	-0.7	0.7
Bone: cortical thickness	0.6	1.0	1.2	-1.1	0.9	-0.9
Bone: cortical thickness	0.3	0.4	0.5	0.0	-0.7	0.7
Bone: cortical tissue density	0.6	0.7	0.9	-1.0	0.8	-0.8
Condit. Reinf. active minus inactive responses	1.8	2.0	2.6	-1.0	1.6	-1.6
Condit. Reinf. active-inactive response ratio	1.4	1.5	2.1	-0.6	1.5	-1.5
Condit. Reinf. active responses	1.4	1.8	2.1	-1.0	1.5	-1.5
Condit. Reinf. inactive responses	0.0	0.1	0.1	-0.4	0.1	-0.1
Incentive salience index mean	0.6	0.8	0.8	-0.8	0.9	-0.9
Condit. Reinf. lever presses	0.2	0.2	0.3	-0.0	-0.6	0.6
Condit. Reinf. active minus inactive responses	0.6	0.8	1.9	1.4	-0.4	0.4
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.2	0.3	-0.5	0.5
Condit. Reinf. active responses	0.8	1.1	3.0	1.7	-0.4	0.4
Condit. Reinf. inactive responses	0.6	0.8	2.3	1.5	0.1	-0.1
Condit. Reinf. lever presses	8.4	11.4	18.4	4.3	-2.8	2.8
Condit. Reinf. lever reinforcers received	1.2	1.6	3.9	2.0	-0.7	0.7
Conditioned reinforcement - actives	3.8	3.8	3.8	1.9	-2.0	2.0
Conditioned reinforcement - inactives	0.1	0.1	0.1	-0.0	-0.4	0.4
Conditioned locomotion	3.1	3.7	3.7	1.9	-1.9	1.9
Patch foraging indifference point 0 sec	1.6	2.5	6.3	2.5	-0.8	0.8
Patch foraging indifference point AUC	0.1	0.1	0.2	-0.3	0.4	-0.4
Delay disc. indifference point, 0s delay	0.1	0.1	0.3	0.6	-0.2	0.2
Delay disc. indifference point, 16s delay	1.6	1.6	2.3	0.6	-1.5	1.5
Delay disc. indifference point, 2s delay	0.8	0.9	1.5	1.2	-0.8	0.8
Delay disc. indifference point, 24s delay	0.3	0.3	0.5	-0.7	-0.4	0.4
Delay disc. indifference point, 4s delay	0.5	0.5	0.7	0.4	-0.8	0.8
Delay disc. indifference point, 8s delay	1.7	1.8	2.4	0.7	-1.6	1.6
Indifference point function ln k	1.9	2.7	3.4	1.8	-1.5	1.5
Indifference point function log k	1.9	2.7	3.4	1.8	-1.5	1.5
Patch foraging total patch changes 0 sec	1.4	2.2	5.4	2.3	-0.8	0.8
Patch foraging total patch changes 12 sec	0.1	0.1	0.1	0.3	0.3	-0.3
Patch foraging total patch changes 18 sec	0.2	0.2	0.5	0.7	-0.3	0.3
Patch foraging total patch changes 24 sec	0.1	0.1	0.1	0.3	0.3	-0.3
Patch foraging total patch changes 6 sec	0.3	0.5	1.4	1.2	-0.0	0.0
Patch foraging time to switch 0 sec	1.2	1.9	4.2	-2.1	0.9	-0.9
Patch foraging water rate 0 sec	1.6	2.6	4.4	2.1	-1.3	1.3
Patch foraging water rate 12 sec	1.8	2.8	4.3	2.1	-1.4	1.4
Patch foraging water rate 18 sec	0.4	0.5	0.7	0.8	-0.7	0.7
Patch foraging water rate 24 sec	2.1	2.9	3.1	1.6	-1.8	1.8
Patch foraging water rate 6 sec	1.6	2.4	2.7	1.3	-1.6	1.6
Seeking ratio, delayed vs. immediate footshock	0.6	0.6	1.8	-1.3	-0.2	0.2
Distance traveled before self-admin	0.3	0.3	0.3	-0.5	0.6	-0.6
Distance traveled after self-admin	0.1	0.1	0.1	-0.2	0.4	-0.4
Extensor digitorum longus weight	0.3	1.2	3.0	-1.7	0.6	-0.6
Bone: elastic displacement	0.4	0.4	1.2	-1.1	-0.1	0.1
Bone: elastic work	0.7	0.9	1.1	-0.7	-1.0	1.0
Bone: endosteal estimation	0.0	0.0	0.0	0.1	0.1	-0.1
Bone: endosteal perimeter	0.3	0.6	1.2	1.1	-0.5	0.5
Epididymis fat weight	4.3	10.0	11.1	-2.8	3.3	-3.3
Delta time in closed arm before/after self-admin	0.8	0.8	2.0	-1.4	0.4	-0.4
Delta time in open arm before/after self-admin	0.5	0.4	1.2	1.1	-0.2	0.2
Diff in mean of infusions in LGA sessions	2.9	3.2	4.0	-2.0	1.7	-1.7
Delay discount exponential model param	1.0	1.1	1.5	-0.5	1.2	-1.2
Extinction: sum of active levers before priming	0.1	0.1	0.2	-0.5	0.2	-0.2
Active lever presses in extinction session 6	2.8	2.7	6.7	2.6	-0.9	0.9
Bone: final force	0.0	0.1	0.1	-0.0	-0.3	0.3
Bone: final moment	0.0	0.1	0.1	0.1	-0.3	0.3
Food consumed during 24 hour testing period	4.7	5.7	7.5	2.7	-2.2	2.2
Glucose	0.2	0.3	0.4	0.4	-0.6	0.6
Heart weight	0.7	0.9	1.2	1.1	-0.9	0.9
Delay discount hyperbolic model param	1.0	1.1	1.4	-0.6	1.2	-1.2
Intermittent access intake day 1-15 change	4.5	4.5	4.9	1.9	-2.2	2.2
Intermittent access intake escalation	5.0	4.9	5.2	2.1	-2.3	2.3
Intermittent access intake escalation 2	0.8	0.8	0.8	0.9	-0.9	0.9
Intermitt. access day 1 inactive lever presses	0.2	0.2	0.5	-0.7	0.2	-0.2
Intermitt. access day 15 inactive lever presses	0.3	0.3	0.4	0.2	-0.6	0.6
Intermitt. access escalation Index	0.0	0.0	0.0	0.1	0.0	-0.0
Intermittent access day 1 total infusions	0.3	0.4	0.4	0.5	-0.7	0.7
Intermittent access day 15 total infusions	5.1	5.7	6.6	2.0	-2.6	2.6
Intermittent access terminal intake (last 3 days)	2.5	2.8	3.3	1.3	-1.8	1.8
Intermittent access total infusions	1.2	1.3	1.7	0.8	-1.3	1.3
Intermittent access day 1 locomotion	0.3	0.3	0.5	0.3	-0.7	0.7
Intermittent access day 15 total locomotion	1.7	1.8	2.1	1.5	-1.3	1.3
Intermittent access total locomotion	0.4	0.5	0.6	0.6	-0.8	0.8
Intermittent access standard deviation	0.1	0.1	0.1	0.1	-0.4	0.4
Left kidney weight	0.2	0.6	0.9	-0.2	0.9	-0.9
Right kidney weight	0.3	0.8	1.2	-0.1	1.1	-1.1
Cocaine induced anxiety	1.1	1.3	2.1	-1.5	0.9	-0.9
Post-drug Anxiety	0.1	0.1	0.3	-0.5	-0.0	0.0
Baseline Anxiety	2.7	2.9	2.9	1.7	-1.7	1.7
Tail length	2.4	7.1	10.2	-1.0	3.2	-3.2
Length with tail	1.7	6.1	8.4	-1.2	2.9	-2.9
Length without tail	0.0	0.0	0.1	-0.1	-0.2	0.2
Times rat made contact with spout	0.9	1.0	1.3	-0.7	1.1	-1.1
Lifetime Intake	1.6	1.8	2.2	1.0	-1.5	1.5
Liver weight, left	1.3	2.1	2.6	-1.1	1.6	-1.6
Liver weight, right	6.2	10.3	12.0	-2.6	3.5	-3.5
Locomotor activity	0.4	0.6	1.1	1.1	0.6	-0.6
Locomotor testing distance	0.3	0.4	0.8	0.9	0.5	-0.5
Locomotor testing rearing	1.6	2.5	3.7	-0.4	1.9	-1.9
Locomotion in novel chamber	1.7	2.1	2.4	1.5	-1.4	1.4
Locomotion in novel chamber post-restriction	4.8	5.8	8.7	3.0	-2.1	2.1
Fecal boli incidents, locomotor time 1	2.5	2.8	3.5	1.2	-1.9	1.9
Change in fecal boli incidents, locomotor task	0.5	0.5	0.6	-0.5	0.8	-0.8
Time >=10cm from walls, locomotor time 1	2.0	2.1	3.2	1.8	-1.2	1.2
Bouts of movement, locomotor time 1	0.1	0.1	0.2	0.4	-0.2	0.2
Total resting periods, locomotor time 1	0.3	0.3	0.4	0.5	-0.6	0.6
Rest time, locomotor task time 1	0.6	0.7	0.9	0.6	-0.9	0.9
Distance moved, locomotor task time 1	0.4	0.4	0.6	-0.8	0.6	-0.6
Vertical activity count, locomotor time 1	0.1	0.1	0.1	-0.4	0.4	-0.4
Time >=10cm from walls, locomotor time 2	0.3	0.3	0.8	0.9	-0.3	0.3
Bouts of movement, locomotor time 2	0.2	0.3	0.4	0.7	-0.4	0.4
Total resting periods, locomotor time 2	0.2	0.2	0.3	0.6	-0.5	0.5
Rest time, locomotor task time 2	0.5	0.6	1.1	-1.1	0.5	-0.5
Distance moved, locomotor task time 2	0.2	0.3	0.6	0.8	-0.4	0.4
Vertical activity count, locomotor time 2	0.0	0.0	0.0	-0.0	0.1	-0.1
Light reinforcement 1	3.2	5.8	7.0	-1.9	2.6	-2.6
Light reinforcement 2	0.5	0.7	1.0	0.3	1.0	-1.0
Bone: marrow area	0.0	0.0	0.0	0.0	0.2	-0.2
Bone: maximum diameter	0.1	0.2	0.5	0.7	-0.1	0.1
Bone: maximum force	0.2	0.4	0.5	0.3	-0.7	0.7
Bone: maximum moment	0.2	0.4	0.5	0.4	-0.7	0.7
Mean time between licks in bursts	0.4	0.6	1.3	1.1	-0.5	0.5
Mean num. licks in bursts	2.1	2.5	4.4	2.1	-1.3	1.3
Cd content in liver	1.6	1.7	2.7	-1.6	1.1	-1.1
Co content in liver	0.0	0.0	0.0	-0.1	-0.1	0.1
Cu content in liver	0.1	0.1	0.1	0.3	0.3	-0.3
Fe content in liver	0.2	0.2	0.3	-0.2	-0.6	0.6
K content in liver	0.1	0.1	0.1	-0.3	0.3	-0.3
Mg content in liver	0.1	0.1	0.2	0.4	-0.3	0.3
Mn content in liver	0.0	0.0	0.1	-0.2	-0.2	0.2
Na content in liver	1.2	1.3	2.2	1.5	-0.9	0.9
Rb content in liver	0.1	0.1	0.2	0.5	-0.1	0.1
Se content in liver	0.6	0.7	1.9	-1.4	0.3	-0.3
Sr content in liver	0.7	0.6	0.9	0.3	-1.0	1.0
Zn content in liver	1.1	1.2	2.9	1.7	-0.6	0.6
Bone: minimum diameter	1.1	2.0	2.3	-1.2	1.5	-1.5
Time in familiar zone, hab. session 1	0.0	0.0	0.1	-0.3	-0.1	0.1
Time in novel zone, hab. session 1	0.6	0.6	0.6	-0.7	0.8	-0.8
Total zone transitions, hab. session 1	0.2	0.3	0.9	0.9	0.0	-0.0
Total locomotion distance, hab. session 1	6.6	9.4	12.0	-2.1	3.5	-3.5
Locomotion velocity, hab. session 1	5.5	7.8	10.3	-1.7	3.2	-3.2
Time in familiar zone, hab. session 2	0.3	0.3	0.3	0.4	-0.6	0.6
Time in novel zone, hab. session 2	0.0	0.0	0.0	-0.1	0.1	-0.1
Total zone transitions, hab. session 2	0.6	0.8	2.3	1.5	0.1	-0.1
Total locomotion distance, hab. session 2	5.2	6.9	9.3	-1.5	3.0	-3.0
Locomotion velocity, hab. session 2	5.9	8.0	10.7	-1.6	3.3	-3.3
Novel to familiar place preference ratio	0.1	0.1	0.2	0.4	0.3	-0.3
Novelty place preference	0.0	0.0	0.1	0.3	0.1	-0.1
Time in novel zone, NPP test	0.1	0.1	0.2	0.5	-0.1	0.1
Total zone transitions, NPP test	0.4	0.5	0.7	0.9	-0.6	0.6
Total locomotion distance, NPP test	4.1	5.7	6.4	-2.0	2.5	-2.5
Locomotion velocity, NPP test	5.0	7.1	8.2	-2.2	2.9	-2.9
Intraocular pressure	3.2	4.4	6.1	1.1	-2.5	2.5
Delta distance traveled before/after self-admin	0.2	0.3	0.4	0.7	-0.4	0.4
Delta ambulatory time before/after self-admin	0.6	0.7	0.9	0.9	-0.7	0.7
Parametrial fat weight	3.1	6.0	8.0	-1.4	2.8	-2.8
Pavlov. Cond. lever latency	1.0	1.2	1.4	-0.9	1.2	-1.2
Pavlov. Cond. magazine entry latency	0.3	0.3	0.8	0.9	-0.4	0.4
Pavlov. Cond. change in total contacts	0.7	0.8	1.0	0.6	-1.0	1.0
Pavlov. Cond. index score	0.7	0.8	0.9	0.9	-0.9	0.9
Pavlov. Cond. latency score	0.6	0.7	0.8	0.9	-0.8	0.8
Pavlov. Cond. lever contacts	0.6	0.7	1.0	0.4	-1.0	1.0
Pavlov. Cond. magazine entry number	0.8	0.9	1.2	-1.1	0.9	-0.9
Pavlov. Cond. intertrial magazine entries	0.7	0.9	1.2	-1.1	0.8	-0.8
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	1.0	0.8	-1.0	1.0
Pavlov. Cond. response bias	0.2	0.3	0.4	0.3	-0.6	0.6
Pavlov. Cond. lever latency	10.0	13.5	18.9	-4.3	3.3	-3.3
Pavlov. Cond. magazine entry latency	4.4	5.1	5.3	2.3	-2.2	2.2
Pavlov. Cond. change in total contacts	5.8	8.0	12.6	3.5	-2.4	2.4
Pavlov. Cond. index score	8.5	10.9	13.8	3.7	-3.1	3.1
Pavlov. Cond. latency score	8.4	10.4	13.2	3.6	-3.0	3.0
Pavlov. Cond. lever contacts	9.6	13.1	19.9	4.5	-3.1	3.1
Pavlov. Cond. magazine entry number	7.4	9.0	10.2	-2.6	3.2	-3.2
Pavlov. Cond. intertrial magazine entries	2.8	3.6	5.0	-0.9	2.2	-2.2
Pavlov. Cond. lever-magazine prob. diff.	7.7	9.8	12.4	3.5	-2.9	2.9
Pavlov. Cond. response bias	10.4	14.1	19.3	4.4	-3.4	3.4
Time in closed arm before self-admin	2.5	2.9	3.2	1.8	-1.6	1.6
Time in closed arm after self-admin	1.8	1.8	2.7	0.4	-1.6	1.6
Time in open arm before self-admin	2.2	2.4	3.3	-1.8	1.4	-1.4
Time in open arm after self-admin	1.3	1.5	2.0	-0.6	1.4	-1.4
Bone: periosteal estimation	0.0	0.0	0.0	-0.1	0.2	-0.2
Bone: periosteal perimeter	0.1	0.2	0.5	0.7	0.0	-0.0
Bone: post-yield work	0.2	0.3	0.8	0.9	-0.1	0.1
Progressive ratio test 1 active lever presses	0.0	0.0	0.0	-0.1	-0.2	0.2
Progressive ratio test 1 breakpoint	0.0	0.0	0.0	-0.2	-0.0	0.0
Progressive ratio test 1 inactive lever presses	0.2	0.2	0.3	0.1	-0.6	0.6
Progressive ratio test 2 active lever presses	0.6	0.7	0.7	0.8	-0.9	0.9
Progressive ratio test 2 breakpoint	0.4	0.4	0.4	0.6	-0.6	0.6
Progressive ratio test 2 inactive lever presses	0.8	0.9	1.2	0.5	-1.1	1.1
Incentive Sensitization - Responses	0.8	0.8	1.0	1.0	-0.9	0.9
Incentive Sensitization - Breakpoint	0.9	0.9	1.1	1.1	-0.9	0.9
Sum of active levers in priming session hrs 5-6	0.4	0.4	0.6	-0.0	0.8	-0.8
Progressive ratio	0.6	0.7	1.0	0.5	-1.0	1.0
Food seeking constrained by brief footshock	0.5	0.6	1.0	1.0	0.7	-0.7
Seeking ratio, punishment vs. effort	1.1	1.3	2.0	0.2	1.4	-1.4
Retroperitoneal fat weight	10.1	33.3	34.9	-5.5	5.9	-5.9
Reaction time number correct	0.3	0.4	1.2	1.1	0.1	-0.1
Reaction time mean minus median	0.2	0.3	0.4	0.7	0.5	-0.5
Reaction time mean minus median AUC	0.4	0.5	1.3	1.2	0.3	-0.3
Reaction time num false alarms	2.4	3.2	5.5	-2.3	1.5	-1.5
Reaction time num false alarms AUC	0.8	1.1	2.6	-1.6	0.6	-0.6
Reaction time trials correct on left	0.3	0.4	1.2	1.1	0.1	-0.1
Reaction time trials on left	0.3	0.4	1.3	1.1	0.0	-0.0
Reaction time mean	0.5	0.8	0.9	-0.7	1.0	-1.0
Reaction time mean AUC	0.4	0.6	0.6	-0.7	0.7	-0.7
Median of all reaction times	0.3	0.5	0.7	-0.8	0.6	-0.6
Reaction time omissions	0.1	0.1	0.3	-0.5	-0.0	0.0
Reaction time false alarm rate	1.2	1.7	4.5	-2.1	0.6	-0.6
Reaction time premature initiation rate	0.9	1.3	1.7	-0.6	1.3	-1.3
Reaction time premature initiations	0.4	0.6	0.9	0.2	0.9	-0.9
Std. dev. reaction times	0.5	0.7	1.0	-0.3	1.0	-1.0
Reaction time trials completed	0.3	0.4	1.3	1.1	0.0	-0.0
Reaction time trials AUC	0.3	0.4	1.1	1.1	0.2	-0.2
Run reversals in cocaine runway, females	3.5	3.4	4.5	-2.1	1.7	-1.7
Run reversals in cocaine runway, males	2.1	2.0	2.9	0.5	-1.7	1.7
Latency to leave start box in cocaine runway	0.9	1.0	1.4	-1.2	0.9	-0.9
Latency to leave start box in cocaine runway, F	1.3	1.4	2.0	-1.4	1.1	-1.1
Latency to leave start box in cocaine runway, M	0.0	0.0	0.1	0.2	-0.1	0.1
Std. dev. time between licks in bursts	1.0	1.2	1.7	-0.0	1.3	-1.3
Total sessions with >9 infusions	2.1	2.3	2.8	1.7	-1.4	1.4
Short access day 1 total inactive lever presses	0.4	0.5	0.7	0.1	-0.8	0.8
Short access day 10 total inactive lever presses	0.4	0.4	0.6	-0.2	0.8	-0.8
Short access day 1 total infusions	1.4	1.4	2.3	1.5	-1.0	1.0
Short access day 10 total infusions	0.3	0.3	0.4	0.4	-0.6	0.6
Short access total infusions	0.4	0.5	0.6	0.6	-0.8	0.8
Short access day 1 locomotion	4.3	4.6	5.1	2.2	-2.1	2.1
Short access day 10 total locomotion	0.0	0.0	0.0	0.2	-0.2	0.2
Short access total locomotion	0.1	0.1	0.3	0.5	-0.2	0.2
One hour access (0.3 mA shock)	1.2	1.3	1.5	1.0	-1.2	1.2
Compulsive drug intake	0.0	0.0	0.0	0.1	0.0	-0.0
One hour access (shock baseline)	1.2	1.4	1.4	1.1	-1.2	1.2
Social response proportion	1.4	1.5	2.0	-0.8	1.4	-1.4
Social responses	2.6	3.3	3.6	-1.7	1.9	-1.9
Social time	1.5	2.0	2.0	-1.4	1.4	-1.4
Soleus weight	1.1	3.3	3.3	-1.8	1.8	-1.8
Bone: stiffness	0.0	0.0	0.1	-0.2	0.2	-0.2
Tibialis anterior weight	0.2	0.6	0.8	-0.4	0.9	-0.9
Time to tail flick, vehicle, before self-admin	0.6	0.6	1.2	-1.1	0.6	-0.6
Time to tail flick, vehicle, after self-admin	2.5	2.7	2.8	1.6	-1.7	1.7
Time to tail flick, test, before self-admin	0.2	0.2	0.3	-0.2	0.6	-0.6
Time to tail flick, test, after self-admin	0.0	0.0	0.0	-0.1	0.2	-0.2
Delta time to tail flick, vehicle, before/after SA	5.5	5.5	5.9	2.4	-2.3	2.3
Delta time to tail flick, test, before/after SA	0.0	0.0	0.0	0.1	-0.1	0.1
Tibia length	0.9	2.5	4.2	2.0	-1.3	1.3
Ambulatory time before self-admin	0.0	0.0	0.1	-0.3	-0.0	0.0
Ambulatory time after self-admin	0.0	0.1	0.1	0.2	-0.2	0.2
Bone: tissue strength	0.1	0.1	0.2	0.5	-0.3	0.3
Total heroin consumption	0.0	0.0	0.1	0.3	-0.1	0.1
Bone: trabecular number	0.2	0.3	0.8	-0.9	-0.2	0.2
Bone: trabecular spacing	0.8	1.0	2.5	1.6	-0.6	0.6
Bone: trabecular thickness	0.5	0.7	1.3	-1.1	0.6	-0.6
Bone: trabecular tissue density	3.0	4.2	5.3	-1.4	2.3	-2.3
Water consumed over 24 hours	0.2	0.3	0.6	-0.8	0.3	-0.3
Number of responses in last shaping day	1.0	1.0	1.1	-0.9	1.1	-1.1