Hub : Genes

Ubxn2a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	intron excision ratio	chr6_33612759_33614434	0.05	0.04	4.3e-03	0.01	0.03	0	0.02	5.5e-02	1.1e-02	1.6e-01	4.6e-02
2	BLA	intron excision ratio	chr6_33607429_33612601	0.06	0.04	2.1e-03	0.02	0.04	0.01	0.02	3.7e-02	5.6e-03	1.3e-01	2.0e-02
3	OFC	intron excision ratio	chr6_33614571_33622937	0.48	0.17	9.8e-03	-0.01	0.09	0.07	0.07	7.6e-01	4.7e-03	9.9e-03	8.5e-03
4	pVTA	gene expression	Ubxn2a	0.1	0.06	2.0e-04	0	0.04	0.04	0.02	2.2e-01	3.5e-04	2.5e-04	4.5e-03
5	PL	gene expression	Ubxn2a	0.08	0.05	9.0e-03	-0	0.02	0.01	0	7.1e-01	3.9e-03	5.2e-02	2.3e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	2.7	4.7	8.2	-2.9	2.9	1.8	-0.2	-1.9
Area under the delay curve	0.2	0.3	1.2	0.1	-0.1	0.5	1.1	-0.1
BMI with tail	1.1	3.7	5.8	2.0	-2.0	2.1	-0.3	-2.4
BMI without tail	1.4	4.2	9.8	1.3	-1.3	2.7	-0.7	-3.1
Body weight	1.1	4.9	7.9	2.8	-2.8	2.1	0.6	-2.1
Weight adjusted by age	0.0	0.0	0.1	0.2	-0.2	-0.2	-0.1	-0.2
Bone surface	0.8	1.4	2.0	-1.4	1.4	1.3	0.3	-1.1
Bone volume	1.4	2.5	4.2	-2.0	2.1	1.4	0.5	-1.3
Breakpoint value in progressive ratio session	0.8	1.0	1.4	-1.2	1.2	0.9	0.9	-0.7
Number of licking bursts	0.7	1.1	2.6	1.6	-1.6	0.3	0.0	-0.3
Context. condit. distance diff. score	1.3	1.6	2.0	-1.4	1.4	1.1	-0.8	-1.4
Locomotion velocity, session 1	0.1	0.2	0.3	0.4	-0.4	0.5	-0.2	-0.4
Locomotion distance, session 1	0.1	0.1	0.3	-0.5	0.5	-0.1	-0.1	0.2
Locomotion velocity, session 2	0.1	0.1	0.2	0.4	-0.4	0.0	-0.4	-0.0
Locomotion distance, session 2	0.1	0.2	0.6	0.2	-0.2	0.3	0.7	0.1
Locomotion velocity, session 3	0.2	0.2	0.4	-0.2	0.2	0.2	-0.7	-0.5
Locomotion distance, session 3	0.3	0.4	0.8	-0.4	0.4	0.7	-0.3	-0.9
Stereotopy head waving bouts, day 3	1.5	1.8	3.9	-2.0	2.0	0.5	-0.8	-0.5
Stereotopy head waving duration, day 3	0.2	0.3	0.5	-0.6	0.6	-0.3	-0.7	0.0
Locomotion velocity, session 7	0.4	0.5	1.2	-0.2	0.2	1.1	0.3	-1.0
Locomotion distance, session 7	0.4	0.5	1.2	0.4	-0.3	0.9	-0.4	-1.1
Stereotopy head waving bouts, day 7	0.1	0.2	0.3	0.5	-0.5	0.4	0.2	-0.3
Stereotopy head waving duration, day 7	0.1	0.1	0.3	0.1	-0.1	-0.5	-0.3	0.4
Locomotion velocity, session 8	1.0	1.2	2.1	-1.5	1.5	0.7	-0.9	-0.8
Locomotion distance, session 8	1.0	1.4	3.0	-1.7	1.7	0.7	-0.5	-0.8
Degree of sensitization distance	0.4	0.5	0.9	1.0	-0.9	0.5	-0.1	-0.5
Degree of sensitization stereotypy	1.0	1.1	2.3	1.5	-1.5	0.1	0.7	0.2
Conditioned locomotion	1.8	2.1	4.2	-2.1	2.1	0.1	-1.3	-0.7
Cocaine response after cond. corrected	0.5	0.6	2.3	0.5	-0.6	0.5	1.5	0.1
Cocaine response after cond. not corrected	0.5	0.5	1.9	0.3	-0.3	-0.2	1.4	0.8
Cocaine response before conditioning	1.8	2.1	4.3	-1.0	1.0	-2.1	-1.0	1.8
Saline control response	0.4	0.5	1.1	-1.0	1.0	-0.4	0.2	0.4
Bone: connectivity density	1.8	2.8	4.0	-2.0	2.0	1.8	0.1	-1.7
Bone: cortical apparent density	0.9	1.2	4.5	0.0	-0.0	1.3	2.1	-0.1
Bone: cortical area	0.1	0.2	0.4	0.6	-0.6	-0.4	0.3	0.3
Bone: cortical porosity	1.2	1.3	2.6	-0.8	0.8	-1.6	-0.0	1.5
Bone: cortical porosity	0.8	0.9	1.6	-1.3	1.3	-0.8	-0.1	0.7
Bone: cortical thickness	1.0	1.6	2.3	1.5	-1.5	-0.6	1.5	1.1
Bone: cortical thickness	0.2	0.2	0.8	-0.3	0.3	0.0	0.9	0.4
Bone: cortical tissue density	0.9	1.3	4.4	0.1	-0.1	1.4	2.1	-0.2
Condit. Reinf. active minus inactive responses	2.0	2.2	4.6	2.1	-2.1	0.3	1.3	0.1
Condit. Reinf. active-inactive response ratio	1.3	1.4	2.4	1.6	-1.6	0.7	1.1	-0.4
Condit. Reinf. active responses	0.3	0.4	0.7	0.9	-0.9	-0.2	0.6	0.4
Condit. Reinf. inactive responses	0.6	0.7	1.6	-1.2	1.2	-0.5	-0.5	0.3
Incentive salience index mean	0.7	0.9	1.9	1.4	-1.4	-0.2	0.8	0.3
Condit. Reinf. lever presses	0.3	0.4	1.2	-0.0	0.0	-1.1	0.2	1.0
Condit. Reinf. active minus inactive responses	0.1	0.2	0.2	-0.5	0.5	-0.2	0.5	0.4
Condit. Reinf. active-inactive response ratio	0.4	0.5	1.4	0.1	-0.1	-1.2	0.1	1.0
Condit. Reinf. active responses	0.2	0.3	0.9	0.2	-0.2	-0.3	0.9	0.8
Condit. Reinf. inactive responses	0.1	0.1	0.2	0.2	-0.2	0.2	0.4	0.1
Condit. Reinf. lever presses	0.6	0.8	2.5	0.0	-0.0	-1.1	0.4	1.6
Condit. Reinf. lever reinforcers received	0.3	0.5	1.5	0.3	-0.3	-0.2	1.2	0.8
Conditioned reinforcement - actives	1.0	1.7	3.0	-1.7	1.7	-0.6	1.0	1.1
Conditioned reinforcement - inactives	1.4	2.0	3.4	-1.8	1.8	-1.1	0.0	1.5
Conditioned locomotion	1.2	1.5	2.2	-1.4	1.4	-0.0	1.5	1.2
Patch foraging indifference point 0 sec	0.2	0.4	0.6	-0.6	0.6	0.3	-0.8	-0.7
Patch foraging indifference point AUC	1.0	1.5	5.8	-0.5	0.5	-1.1	-2.4	-0.1
Delay disc. indifference point, 0s delay	0.8	0.9	2.1	1.0	-1.0	-0.0	1.4	0.6
Delay disc. indifference point, 16s delay	0.1	0.1	0.4	-0.0	0.0	0.2	0.6	-0.2
Delay disc. indifference point, 2s delay	0.6	0.7	2.8	0.5	-0.5	0.3	1.7	0.5
Delay disc. indifference point, 24s delay	1.7	1.9	3.1	-1.8	1.8	1.2	1.1	-0.9
Delay disc. indifference point, 4s delay	0.1	0.1	0.3	0.1	-0.2	-0.6	0.2	0.6
Delay disc. indifference point, 8s delay	0.4	0.4	0.9	-0.3	0.3	0.9	0.9	-0.5
Indifference point function ln k	0.4	0.8	2.1	-0.9	0.8	0.2	1.4	0.6
Indifference point function log k	0.4	0.8	2.1	-0.9	0.8	0.2	1.4	0.6
Patch foraging total patch changes 0 sec	0.2	0.3	0.5	-0.5	0.5	0.3	-0.7	-0.6
Patch foraging total patch changes 12 sec	0.6	0.8	2.0	0.9	-0.9	-0.4	-1.4	-0.6
Patch foraging total patch changes 18 sec	0.9	1.4	4.2	-0.5	0.5	0.6	-2.1	-1.4
Patch foraging total patch changes 24 sec	0.2	0.3	0.5	0.7	-0.7	-0.0	-0.7	-0.4
Patch foraging total patch changes 6 sec	0.4	0.7	2.4	0.6	-0.5	-0.4	-1.5	-0.4
Patch foraging time to switch 0 sec	0.9	1.9	4.3	0.6	-0.6	2.1	1.4	-1.5
Patch foraging water rate 0 sec	1.2	2.6	3.9	-2.0	2.0	-1.7	-0.8	1.4
Patch foraging water rate 12 sec	0.4	0.9	1.5	0.9	-0.9	-0.8	1.0	1.2
Patch foraging water rate 18 sec	2.2	3.4	8.2	-0.7	0.7	-2.8	0.4	2.9
Patch foraging water rate 24 sec	0.0	0.0	0.0	-0.1	0.1	-0.0	-0.1	-0.1
Patch foraging water rate 6 sec	1.1	1.7	4.2	-0.4	0.3	-1.9	0.3	2.1
Seeking ratio, delayed vs. immediate footshock	0.5	0.6	1.0	0.9	-0.9	-1.0	-0.6	0.4
Distance traveled before self-admin	0.1	0.1	0.2	0.1	-0.1	0.4	-0.2	-0.4
Distance traveled after self-admin	0.3	0.3	1.0	0.1	-0.2	-1.0	-0.7	0.2
Extensor digitorum longus weight	0.4	1.8	4.2	-2.0	2.0	0.5	0.5	0.1
Bone: elastic displacement	0.6	0.6	1.3	-1.2	1.1	0.2	0.7	0.1
Bone: elastic work	0.5	0.7	1.1	-1.1	1.1	0.3	1.0	0.2
Bone: endosteal estimation	0.5	1.1	1.9	-1.4	1.4	0.3	-1.1	-0.8
Bone: endosteal perimeter	0.3	0.7	2.3	-0.5	0.5	0.2	-1.5	-0.9
Epididymis fat weight	5.4	18.6	40.5	6.4	-6.3	1.9	-1.0	-2.9
Delta time in closed arm before/after self-admin	0.2	0.2	0.3	-0.5	0.5	-0.1	-0.5	-0.2
Delta time in open arm before/after self-admin	0.5	0.5	0.7	0.8	-0.7	0.7	-0.3	-0.9
Diff in mean of infusions in LGA sessions	0.2	0.3	0.7	0.4	-0.4	0.5	0.1	-0.8
Delay discount exponential model param	0.3	0.3	0.9	0.3	-0.3	-0.6	-1.0	0.2
Extinction: sum of active levers before priming	0.3	0.4	0.7	-0.8	0.8	0.0	-0.6	-0.5
Active lever presses in extinction session 6	0.3	0.3	0.6	-0.5	0.5	-0.8	-0.5	-0.1
Bone: final force	0.2	0.4	0.6	0.8	-0.8	-0.6	-0.1	0.5
Bone: final moment	0.1	0.2	0.3	0.6	-0.6	-0.5	-0.1	0.4
Food consumed during 24 hour testing period	0.7	1.0	2.2	0.3	-0.3	-1.5	-1.2	1.1
Glucose	0.7	1.1	2.3	0.6	-0.6	1.5	0.1	-1.5
Heart weight	0.2	0.4	0.8	0.9	-0.9	-0.4	-0.3	0.1
Delay discount hyperbolic model param	0.2	0.3	0.9	0.1	-0.1	-0.6	-1.0	0.2
Intermittent access intake day 1-15 change	0.7	1.4	2.4	-1.5	1.5	0.7	1.4	-0.0
Intermittent access intake escalation	0.6	1.2	2.1	-1.3	1.3	0.6	1.4	0.0
Intermittent access intake escalation 2	0.9	1.1	1.6	-1.3	1.2	1.0	1.0	-0.5
Intermitt. access day 1 inactive lever presses	0.1	0.5	1.0	-0.2	0.2	-1.0	-0.7	0.8
Intermitt. access day 15 inactive lever presses	0.6	1.3	4.1	-0.7	0.7	-1.2	-2.0	0.5
Intermitt. access escalation Index	0.5	0.6	0.8	0.9	-0.9	0.6	-0.7	-0.9
Intermittent access day 1 total infusions	0.3	0.5	1.4	-0.5	0.5	-0.7	0.5	1.2
Intermittent access day 15 total infusions	0.8	1.2	2.9	-1.0	1.0	0.0	1.7	0.9
Intermittent access terminal intake (last 3 days)	1.5	2.0	4.1	-0.8	0.8	-1.1	1.8	2.0
Intermittent access total infusions	1.2	1.4	3.2	-0.8	0.8	-0.4	1.8	1.4
Intermittent access day 1 locomotion	1.2	1.5	3.7	-0.1	0.1	-0.4	1.9	1.9
Intermittent access day 15 total locomotion	0.5	0.9	2.1	0.3	-0.3	-0.4	1.4	1.4
Intermittent access total locomotion	1.7	2.1	6.7	-0.2	0.2	-0.3	2.6	1.9
Intermittent access standard deviation	0.3	0.6	1.3	-1.1	1.1	-0.1	0.5	0.6
Left kidney weight	0.1	0.2	0.5	0.4	-0.4	0.6	-0.1	-0.7
Right kidney weight	0.2	0.9	1.6	1.2	-1.2	0.6	-0.3	-0.9
Cocaine induced anxiety	1.6	2.3	4.1	-1.4	1.4	2.0	0.1	-1.9
Post-drug Anxiety	0.7	0.8	1.9	0.2	-0.2	0.7	-1.2	-1.4
Baseline Anxiety	2.3	2.6	3.9	2.0	-2.0	-1.7	-1.3	0.8
Tail length	0.0	0.1	0.4	-0.2	0.2	0.3	0.6	0.1
Length with tail	0.2	0.7	1.1	1.0	-1.0	0.3	1.1	0.1
Length without tail	0.2	0.5	1.0	1.0	-1.0	-0.4	0.5	0.4
Times rat made contact with spout	1.0	1.2	2.4	-1.5	1.5	-0.4	-1.0	-0.1
Lifetime Intake	1.3	1.5	3.1	-0.8	0.8	-0.6	1.7	1.8
Liver weight, left	2.5	4.2	8.3	2.9	-2.9	-0.7	1.5	1.3
Liver weight, right	2.6	4.6	6.2	2.3	-2.3	2.5	1.7	-1.8
Locomotor activity	1.2	1.9	4.2	2.0	-2.0	0.7	-0.1	-0.8
Locomotor testing distance	0.7	1.2	1.8	1.4	-1.3	0.9	-0.6	-1.2
Locomotor testing rearing	0.1	0.1	0.3	0.5	-0.5	0.0	-0.1	-0.1
Locomotion in novel chamber	1.5	1.9	3.4	1.9	-1.8	0.7	1.6	0.1
Locomotion in novel chamber post-restriction	0.4	0.7	1.3	1.1	-1.1	-0.4	0.3	0.7
Fecal boli incidents, locomotor time 1	0.9	1.3	2.5	-1.6	1.6	0.7	0.9	-0.2
Change in fecal boli incidents, locomotor task	0.7	0.7	1.2	1.0	-1.0	-1.1	-0.5	0.4
Time >=10cm from walls, locomotor time 1	1.4	1.5	4.1	-0.8	0.8	2.0	0.3	-1.4
Bouts of movement, locomotor time 1	0.1	0.1	0.1	-0.3	0.3	0.3	0.1	-0.0
Total resting periods, locomotor time 1	0.3	0.3	0.5	-0.7	0.7	0.6	-0.2	-0.4
Rest time, locomotor task time 1	0.2	0.3	0.6	-0.4	0.4	0.8	-0.3	-0.7
Distance moved, locomotor task time 1	0.3	0.5	1.0	1.0	-1.0	-0.4	0.2	0.4
Vertical activity count, locomotor time 1	0.2	0.6	1.6	0.7	-0.7	0.2	1.3	0.4
Time >=10cm from walls, locomotor time 2	1.4	2.1	3.9	-1.6	1.6	2.0	-0.1	-1.3
Bouts of movement, locomotor time 2	0.0	0.0	0.0	0.0	-0.0	0.0	0.1	0.1
Total resting periods, locomotor time 2	0.0	0.0	0.0	-0.1	0.1	0.1	-0.1	-0.1
Rest time, locomotor task time 2	0.2	0.3	0.7	-0.2	0.2	0.8	0.0	-0.7
Distance moved, locomotor task time 2	0.8	0.9	2.4	0.6	-0.6	-1.2	0.4	1.5
Vertical activity count, locomotor time 2	0.1	0.2	0.6	-0.1	0.1	-0.2	0.4	0.8
Light reinforcement 1	0.0	0.1	0.3	0.0	-0.0	-0.2	0.5	0.5
Light reinforcement 2	0.7	1.1	1.8	-1.3	1.3	-0.7	0.6	1.1
Bone: marrow area	0.5	1.0	1.7	-1.3	1.3	0.2	-1.0	-0.7
Bone: maximum diameter	0.3	0.6	1.8	-0.6	0.6	-0.8	-1.3	-0.0
Bone: maximum force	0.1	0.2	0.4	0.4	-0.4	-0.6	-0.1	0.6
Bone: maximum moment	0.1	0.1	0.2	0.1	-0.1	-0.5	-0.1	0.4
Mean time between licks in bursts	0.2	0.5	1.6	0.5	-0.5	0.2	-1.3	-0.6
Mean num. licks in bursts	1.5	2.3	5.7	-2.4	2.4	-0.4	-0.5	0.1
Cd content in liver	0.4	0.5	1.2	-0.0	0.0	1.0	-0.5	-1.1
Co content in liver	0.5	0.6	0.8	-0.8	0.8	-0.4	0.8	0.9
Cu content in liver	0.8	1.0	2.7	0.0	-0.0	1.6	0.4	-1.4
Fe content in liver	1.5	1.9	3.8	-1.9	1.9	-0.3	-1.3	-0.2
K content in liver	0.6	0.5	0.7	0.8	-0.8	-0.8	-0.8	0.2
Mg content in liver	0.0	0.0	0.1	-0.0	0.0	0.3	0.1	-0.3
Mn content in liver	0.8	0.9	2.1	0.6	-0.6	1.2	1.4	-0.6
Na content in liver	1.4	1.5	3.3	-0.9	0.9	-1.8	-0.4	1.6
Rb content in liver	1.1	1.3	4.8	-0.6	0.6	-0.1	-2.2	-0.9
Se content in liver	0.3	0.3	0.7	0.8	-0.8	0.2	0.4	0.1
Sr content in liver	0.9	0.8	1.2	-1.1	1.1	1.0	0.4	-0.7
Zn content in liver	0.7	0.8	1.9	1.4	-1.4	-0.0	-0.4	-0.3
Bone: minimum diameter	0.5	0.9	2.1	1.5	-1.4	0.4	0.2	-0.4
Time in familiar zone, hab. session 1	0.7	0.7	1.3	1.2	-1.1	0.7	0.4	-0.3
Time in novel zone, hab. session 1	0.2	0.2	0.6	-0.2	0.2	0.4	-0.5	-0.7
Total zone transitions, hab. session 1	0.3	0.4	0.7	-0.5	0.5	-0.7	-0.8	0.3
Total locomotion distance, hab. session 1	0.2	0.3	0.5	-0.6	0.6	-0.6	0.1	0.7
Locomotion velocity, hab. session 1	0.7	1.0	2.1	-0.7	0.7	-1.4	0.1	1.5
Time in familiar zone, hab. session 2	0.3	0.3	0.7	-0.1	0.1	0.8	0.7	-0.5
Time in novel zone, hab. session 2	0.4	0.4	1.0	0.2	-0.2	1.0	0.0	-1.0
Total zone transitions, hab. session 2	0.5	0.7	1.8	-0.8	0.8	-0.3	-1.3	-0.4
Total locomotion distance, hab. session 2	0.6	0.8	1.8	-0.8	0.8	0.2	-1.3	-0.8
Locomotion velocity, hab. session 2	0.7	0.9	2.7	-0.8	0.8	-0.2	-1.6	-0.6
Novel to familiar place preference ratio	0.1	0.1	0.2	0.2	-0.2	0.4	0.1	-0.3
Novelty place preference	0.2	0.2	0.4	0.6	-0.6	0.4	0.2	-0.2
Time in novel zone, NPP test	0.3	0.3	0.7	0.5	-0.5	0.9	0.2	-0.6
Total zone transitions, NPP test	0.9	1.3	3.2	-1.2	1.2	-0.3	-1.8	-0.4
Total locomotion distance, NPP test	1.0	1.4	2.8	-1.7	1.7	0.0	-1.1	-0.5
Locomotion velocity, NPP test	1.0	1.5	2.5	-1.6	1.6	-0.7	-1.3	0.2
Intraocular pressure	1.2	1.7	3.1	1.2	-1.2	1.8	0.7	-1.5
Delta distance traveled before/after self-admin	0.8	0.8	2.0	0.8	-0.8	-1.4	-0.8	0.6
Delta ambulatory time before/after self-admin	0.2	0.3	0.9	-0.3	0.3	-1.0	-0.4	0.4
Parametrial fat weight	11.4	26.8	60.0	7.7	-7.7	2.6	0.8	-2.7
Pavlov. Cond. lever latency	0.1	0.1	0.2	0.5	-0.5	0.1	0.4	0.2
Pavlov. Cond. magazine entry latency	0.3	0.4	1.0	-0.5	0.5	0.7	-0.4	-1.0
Pavlov. Cond. change in total contacts	1.2	1.3	3.1	-0.1	0.1	1.8	1.5	-1.0
Pavlov. Cond. index score	0.2	0.3	0.5	-0.4	0.4	0.6	0.0	-0.7
Pavlov. Cond. latency score	0.3	0.4	0.7	-0.6	0.6	0.6	-0.3	-0.8
Pavlov. Cond. lever contacts	0.0	0.0	0.0	-0.2	0.2	-0.2	-0.0	0.1
Pavlov. Cond. magazine entry number	0.7	0.9	1.8	0.8	-0.9	-1.1	0.3	1.3
Pavlov. Cond. intertrial magazine entries	0.4	0.5	1.0	-1.0	1.0	0.1	0.5	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.4	-0.6	0.6	0.6	0.2	-0.6
Pavlov. Cond. response bias	0.4	0.5	0.9	-1.0	1.0	0.5	-0.2	-0.7
Pavlov. Cond. lever latency	1.2	1.7	3.0	1.0	-0.9	1.7	1.5	-1.1
Pavlov. Cond. magazine entry latency	0.4	0.5	1.8	-0.4	0.4	-0.7	-1.3	0.0
Pavlov. Cond. change in total contacts	0.5	0.9	2.2	-0.3	0.3	-1.3	-1.5	0.7
Pavlov. Cond. index score	1.2	1.6	3.0	-0.8	0.8	-1.7	-1.6	1.1
Pavlov. Cond. latency score	1.3	1.7	2.9	-1.0	0.9	-1.7	-1.6	1.0
Pavlov. Cond. lever contacts	1.1	1.5	3.2	-0.6	0.6	-1.8	-1.5	1.1
Pavlov. Cond. magazine entry number	0.4	0.5	2.2	0.3	-0.3	0.5	1.5	0.2
Pavlov. Cond. intertrial magazine entries	1.3	2.0	4.2	1.3	-1.3	1.5	2.1	-0.5
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.3	2.6	-0.7	0.7	-1.4	-1.6	0.8
Pavlov. Cond. response bias	1.1	1.5	2.8	-1.0	0.9	-1.5	-1.7	0.8
Time in closed arm before self-admin	0.3	0.4	1.6	0.1	-0.1	-0.2	-1.3	-0.3
Time in closed arm after self-admin	1.1	1.2	1.8	1.2	-1.2	-1.3	-0.6	1.0
Time in open arm before self-admin	0.3	0.4	1.5	0.3	-0.3	0.1	1.2	0.4
Time in open arm after self-admin	0.7	0.8	2.2	-0.1	0.2	1.5	0.7	-1.1
Bone: periosteal estimation	0.1	0.2	0.5	-0.7	0.7	-0.2	-0.5	-0.2
Bone: periosteal perimeter	0.3	0.5	1.9	-0.2	0.2	-0.6	-1.4	-0.2
Bone: post-yield work	1.1	1.6	3.1	-1.7	1.7	-0.6	-1.3	0.2
Progressive ratio test 1 active lever presses	0.9	1.1	3.4	-0.1	0.1	-1.1	0.9	1.8
Progressive ratio test 1 breakpoint	0.8	0.9	2.9	-0.3	0.3	-1.0	0.8	1.7
Progressive ratio test 1 inactive lever presses	1.0	1.5	3.5	-0.6	0.6	-1.6	-0.8	1.9
Progressive ratio test 2 active lever presses	1.4	1.6	4.4	-0.8	0.8	-0.3	2.1	1.4
Progressive ratio test 2 breakpoint	1.5	1.8	5.3	-0.7	0.7	-0.3	2.3	1.5
Progressive ratio test 2 inactive lever presses	0.9	1.4	2.5	-1.3	1.3	-1.0	0.3	1.6
Incentive Sensitization - Responses	1.3	1.8	6.6	-0.9	0.8	0.8	2.6	0.3
Incentive Sensitization - Breakpoint	1.4	1.9	7.8	-0.6	0.6	0.7	2.8	0.5
Sum of active levers in priming session hrs 5-6	0.6	0.6	1.3	-0.3	0.3	1.1	0.4	-1.1
Progressive ratio	0.3	0.5	2.3	-0.1	0.1	0.2	-1.5	-0.5
Food seeking constrained by brief footshock	2.7	3.3	8.1	-2.8	2.8	-0.2	-0.6	0.3
Seeking ratio, punishment vs. effort	0.6	0.9	1.7	-1.3	1.3	-0.8	0.0	0.7
Retroperitoneal fat weight	13.6	57.9	129.0	11.4	-11.3	3.9	0.5	-4.3
Reaction time number correct	0.1	0.2	0.5	-0.7	0.7	-0.1	-0.3	0.0
Reaction time mean minus median	1.6	4.0	10.0	1.1	-1.1	3.2	1.6	-2.3
Reaction time mean minus median AUC	1.0	2.6	5.3	1.3	-1.3	2.3	1.2	-1.7
Reaction time num false alarms	0.7	1.0	2.0	0.9	-0.9	0.4	-1.2	-1.4
Reaction time num false alarms AUC	0.7	1.1	2.0	1.2	-1.1	0.7	-0.7	-1.4
Reaction time trials correct on left	0.1	0.2	0.5	-0.7	0.7	-0.1	-0.3	0.0
Reaction time trials on left	0.1	0.2	0.4	-0.6	0.6	0.1	-0.2	-0.1
Reaction time mean	3.1	4.9	13.3	0.6	-0.6	3.6	2.3	-2.3
Reaction time mean AUC	2.8	4.5	12.2	0.6	-0.6	3.5	2.3	-2.2
Median of all reaction times	3.0	4.2	11.9	0.2	-0.1	3.4	2.2	-2.1
Reaction time omissions	3.0	4.4	10.3	1.3	-1.2	3.2	1.0	-2.8
Reaction time false alarm rate	0.8	1.1	2.2	1.5	-1.5	0.3	-0.3	-0.9
Reaction time premature initiation rate	0.7	1.0	2.0	-0.7	0.7	-1.3	-1.4	0.6
Reaction time premature initiations	0.6	1.1	1.7	-1.1	1.1	-1.1	-1.3	0.4
Std. dev. reaction times	3.0	5.5	14.1	1.1	-1.0	3.8	1.9	-2.8
Reaction time trials completed	0.1	0.2	0.4	-0.6	0.6	0.1	-0.2	-0.1
Reaction time trials AUC	0.1	0.1	0.2	-0.5	0.5	0.3	0.1	-0.2
Run reversals in cocaine runway, females	1.0	1.0	1.5	-1.2	1.2	-1.0	-1.0	0.4
Run reversals in cocaine runway, males	1.1	1.1	3.1	0.1	-0.1	-1.8	0.1	1.6
Latency to leave start box in cocaine runway	3.7	4.2	5.4	-2.3	2.3	1.2	-2.0	-2.2
Latency to leave start box in cocaine runway, F	1.7	2.0	3.9	-1.4	1.4	0.2	-2.0	-1.4
Latency to leave start box in cocaine runway, M	3.1	2.9	3.7	-1.9	1.9	1.8	-0.8	-1.8
Std. dev. time between licks in bursts	0.3	0.4	0.8	0.1	-0.1	0.7	-0.7	-0.9
Total sessions with >9 infusions	1.3	1.6	3.8	-0.6	0.6	-0.2	1.9	1.9
Short access day 1 total inactive lever presses	1.5	1.9	3.0	-1.6	1.6	-1.2	-0.0	1.7
Short access day 10 total inactive lever presses	1.1	2.6	5.8	-1.3	1.4	1.1	-2.4	-1.6
Short access day 1 total infusions	0.6	0.8	1.5	-0.8	0.8	-0.2	0.9	1.2
Short access day 10 total infusions	0.7	0.9	1.7	-0.8	0.8	-0.6	1.0	1.3
Short access total infusions	0.8	1.0	2.9	-0.4	0.4	-0.6	1.2	1.7
Short access day 1 locomotion	0.6	0.8	2.3	-0.2	0.2	-0.0	1.5	1.2
Short access day 10 total locomotion	0.5	1.0	3.0	-0.6	0.6	0.9	1.7	0.6
Short access total locomotion	1.6	1.9	6.9	-0.3	0.3	0.6	2.6	1.5
One hour access (0.3 mA shock)	2.1	2.4	4.5	-2.1	2.1	0.7	1.6	0.3
Compulsive drug intake	0.6	0.7	1.9	-0.1	0.1	1.4	0.1	-1.2
One hour access (shock baseline)	1.1	1.7	2.3	-1.5	1.5	-0.6	1.4	1.4
Social response proportion	0.5	0.5	2.3	0.2	-0.2	0.0	1.5	0.6
Social responses	0.1	0.2	0.4	0.3	-0.3	0.6	0.2	-0.6
Social time	0.9	1.2	3.9	0.9	-0.8	0.8	2.0	0.1
Soleus weight	1.4	4.2	10.0	-3.2	3.2	-0.6	-0.6	0.5
Bone: stiffness	0.5	0.8	1.9	0.7	-0.7	-1.4	-0.5	1.1
Tibialis anterior weight	0.3	1.1	2.5	-1.6	1.6	0.4	0.3	-0.1
Time to tail flick, vehicle, before self-admin	0.9	0.9	1.4	1.2	-1.2	0.5	1.2	0.1
Time to tail flick, vehicle, after self-admin	1.5	2.0	3.1	1.8	-1.7	1.4	-0.1	-1.5
Time to tail flick, test, before self-admin	1.0	1.0	4.4	-0.1	0.1	-0.0	2.1	0.8
Time to tail flick, test, after self-admin	0.8	0.8	1.6	-0.9	0.9	1.0	1.2	-0.1
Delta time to tail flick, vehicle, before/after SA	0.7	0.7	1.9	0.0	0.0	1.0	-0.8	-1.4
Delta time to tail flick, test, before/after SA	1.3	1.4	2.8	-1.7	1.7	1.0	-0.3	-0.5
Tibia length	0.7	1.9	3.3	1.8	-1.8	-1.1	0.5	1.3
Ambulatory time before self-admin	0.0	0.1	0.1	0.2	-0.3	0.2	-0.2	-0.3
Ambulatory time after self-admin	0.4	0.4	1.3	0.2	-0.2	-1.1	-0.9	0.2
Bone: tissue strength	0.8	0.9	1.8	1.0	-1.0	0.6	1.3	0.2
Total heroin consumption	1.6	1.8	3.7	-1.9	1.9	0.8	1.0	-0.2
Bone: trabecular number	1.9	3.1	5.8	-2.4	2.4	1.4	-0.2	-1.4
Bone: trabecular spacing	1.6	2.1	3.5	1.9	-1.9	-1.0	0.8	1.4
Bone: trabecular thickness	1.5	1.9	3.5	-1.2	1.2	1.7	-0.4	-1.9
Bone: trabecular tissue density	0.3	0.5	1.4	-0.5	0.5	-0.8	-1.2	0.2
Water consumed over 24 hours	0.5	0.7	1.7	-0.3	0.3	1.1	-0.4	-1.3
Number of responses in last shaping day	0.5	0.5	1.2	-1.1	1.1	0.1	-0.4	0.2