Hub : Genes

Ubxn2a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	intron excision ratio	chr6_27887989_27893164	0.06	0.04	2.3e-03	0.04	0.05	0.05	0.05	3.4e-03	1.7e-03	8.6e-04	9.3e-04
2	BLA	intron excision ratio	chr6_27893322_27894997	0.05	0.04	5.0e-03	0.03	0.04	0.05	0.04	6.8e-03	4.3e-03	1.6e-03	2.8e-03
3	PL	gene expression	Ubxn2a	0.12	0.07	1.1e-03	-0	0.01	0.02	0	7.1e-01	7.3e-03	3.5e-03	1.6e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	5.9	9.8	13.0	-3.6	3.6	1.9
Area under the delay curve	0.1	0.1	0.2	0.1	-0.1	0.4
BMI with tail	2.0	6.4	9.5	3.1	-3.1	0.5
BMI without tail	2.0	4.2	6.2	2.5	-2.5	0.5
Body weight	1.9	7.8	10.9	3.3	-3.3	1.2
Weight adjusted by age	0.1	0.1	0.2	0.4	-0.4	0.1
Bone surface	1.7	2.9	3.9	-2.0	2.0	1.0
Bone volume	3.5	5.9	8.2	-2.9	2.8	1.2
Breakpoint value in progressive ratio session	2.5	2.8	3.6	-1.9	1.9	1.1
Number of licking bursts	1.4	1.6	2.3	1.5	-1.5	0.6
Context. condit. distance diff. score	1.6	2.0	2.5	-1.6	1.6	1.0
Locomotion velocity, session 1	0.8	0.8	1.2	0.8	-0.8	1.1
Locomotion distance, session 1	0.1	0.1	0.1	-0.4	0.4	0.2
Locomotion velocity, session 2	0.3	0.3	0.4	0.5	-0.5	0.6
Locomotion distance, session 2	0.1	0.2	0.4	0.3	-0.3	0.6
Locomotion velocity, session 3	0.2	0.2	0.2	-0.5	0.5	0.4
Locomotion distance, session 3	0.2	0.2	0.3	-0.6	0.6	0.3
Stereotopy head waving bouts, day 3	3.0	3.5	4.8	-2.2	2.2	1.0
Stereotopy head waving duration, day 3	0.4	0.5	0.8	-0.9	0.9	0.2
Locomotion velocity, session 7	0.3	0.4	0.8	-0.4	0.4	0.9
Locomotion distance, session 7	0.4	0.5	1.2	0.4	-0.4	1.1
Stereotopy head waving bouts, day 7	0.0	0.1	0.1	0.2	-0.2	-0.2
Stereotopy head waving duration, day 7	0.2	0.2	0.5	-0.2	0.2	-0.7
Locomotion velocity, session 8	1.7	2.0	2.6	-1.6	1.6	0.9
Locomotion distance, session 8	2.0	2.9	4.3	-2.1	2.1	0.6
Degree of sensitization distance	1.1	1.1	1.1	1.0	-1.0	1.0
Degree of sensitization stereotypy	1.0	1.1	1.6	1.3	-1.3	-0.5
Conditioned locomotion	3.3	3.9	5.7	-2.4	2.4	0.7
Cocaine response after cond. corrected	0.2	0.3	0.4	0.6	-0.6	0.1
Cocaine response after cond. not corrected	0.2	0.2	0.2	0.5	-0.5	-0.4
Cocaine response before conditioning	1.1	1.3	2.6	-0.8	0.8	-1.6
Saline control response	0.7	0.9	1.4	-1.2	1.2	-0.3
Bone: connectivity density	3.0	4.6	5.6	-2.4	2.4	1.6
Bone: cortical apparent density	0.5	0.6	1.2	0.6	-0.6	1.1
Bone: cortical area	0.0	0.0	0.1	0.1	-0.1	0.2
Bone: cortical porosity	1.7	1.8	2.0	-1.4	1.4	-1.2
Bone: cortical porosity	1.2	1.3	1.5	-1.2	1.2	-0.9
Bone: cortical thickness	0.5	0.8	1.1	1.1	-1.1	-0.1
Bone: cortical thickness	0.3	0.4	0.6	-0.8	0.7	0.1
Bone: cortical tissue density	0.6	0.8	1.5	0.6	-0.6	1.2
Condit. Reinf. active minus inactive responses	3.1	3.5	5.2	2.3	-2.3	0.3
Condit. Reinf. active-inactive response ratio	1.7	1.9	2.6	1.6	-1.6	0.7
Condit. Reinf. active responses	0.6	0.8	1.2	1.1	-1.1	0.2
Condit. Reinf. inactive responses	0.6	0.7	1.1	-1.0	1.0	0.2
Incentive salience index mean	1.2	1.4	2.1	1.5	-1.5	0.2
Condit. Reinf. lever presses	0.1	0.1	0.3	0.1	-0.1	-0.5
Condit. Reinf. active minus inactive responses	0.2	0.2	0.3	-0.5	0.5	-0.4
Condit. Reinf. active-inactive response ratio	0.3	0.3	1.0	-0.0	0.0	-1.0
Condit. Reinf. active responses	0.1	0.1	0.3	0.2	-0.2	-0.5
Condit. Reinf. inactive responses	0.1	0.1	0.1	0.3	-0.3	0.3
Condit. Reinf. lever presses	0.2	0.2	0.6	0.1	-0.1	-0.8
Condit. Reinf. lever reinforcers received	0.1	0.1	0.1	0.4	-0.4	-0.4
Conditioned reinforcement - actives	2.1	2.1	3.0	-1.7	1.7	-0.4
Conditioned reinforcement - inactives	2.9	3.3	3.5	-1.9	1.8	-1.7
Conditioned locomotion	1.4	1.7	1.8	-1.4	1.3	-1.2
Patch foraging indifference point 0 sec	0.5	0.7	1.1	-1.0	1.0	0.2
Patch foraging indifference point AUC	0.1	0.1	0.1	-0.4	0.4	-0.3
Delay disc. indifference point, 0s delay	1.0	1.1	1.5	1.2	-1.2	-0.7
Delay disc. indifference point, 16s delay	0.1	0.1	0.1	-0.2	0.2	0.3
Delay disc. indifference point, 2s delay	0.4	0.4	0.5	0.7	-0.7	-0.3
Delay disc. indifference point, 24s delay	3.7	3.5	4.2	-2.1	2.0	1.5
Delay disc. indifference point, 4s delay	0.1	0.1	0.2	0.2	-0.2	-0.4
Delay disc. indifference point, 8s delay	0.3	0.4	1.0	-0.2	0.2	1.0
Indifference point function ln k	0.7	1.0	1.4	-1.2	1.2	-0.4
Indifference point function log k	0.7	1.0	1.4	-1.2	1.2	-0.4
Patch foraging total patch changes 0 sec	0.5	0.8	1.2	-1.1	1.1	0.2
Patch foraging total patch changes 12 sec	0.0	0.0	0.1	0.2	-0.2	0.2
Patch foraging total patch changes 18 sec	0.9	1.2	1.3	-1.1	1.1	1.1
Patch foraging total patch changes 24 sec	0.1	0.1	0.1	0.2	-0.2	0.3
Patch foraging total patch changes 6 sec	0.0	0.0	0.1	0.0	-0.0	0.4
Patch foraging time to switch 0 sec	0.7	1.0	1.3	1.0	-0.9	1.1
Patch foraging water rate 0 sec	2.2	3.5	5.1	-2.2	2.2	-0.7
Patch foraging water rate 12 sec	0.4	0.6	0.7	0.8	-0.8	-0.8
Patch foraging water rate 18 sec	2.0	2.8	7.1	-0.8	0.8	-2.7
Patch foraging water rate 24 sec	0.1	0.1	0.1	-0.3	0.3	0.3
Patch foraging water rate 6 sec	0.5	0.7	1.9	-0.2	0.2	-1.4
Seeking ratio, delayed vs. immediate footshock	0.8	1.0	1.1	1.1	-1.0	-0.8
Distance traveled before self-admin	0.2	0.2	0.3	0.5	-0.5	-0.4
Distance traveled after self-admin	0.1	0.1	0.2	-0.3	0.3	-0.4
Extensor digitorum longus weight	0.7	2.9	4.3	-2.1	2.1	0.3
Bone: elastic displacement	0.8	0.9	1.3	-1.1	1.1	0.2
Bone: elastic work	0.7	1.0	1.5	-1.2	1.2	0.0
Bone: endosteal estimation	0.5	1.2	1.8	-1.3	1.3	0.1
Bone: endosteal perimeter	0.1	0.2	0.3	-0.6	0.6	0.1
Epididymis fat weight	8.5	19.9	27.9	5.3	-5.3	2.0
Delta time in closed arm before/after self-admin	0.1	0.0	0.1	-0.2	0.2	-0.3
Delta time in open arm before/after self-admin	0.7	0.7	1.1	0.7	-0.6	1.1
Diff in mean of infusions in LGA sessions	0.3	0.4	1.0	-0.2	0.2	1.0
Delay discount exponential model param	0.1	0.2	0.3	0.2	-0.2	-0.6
Extinction: sum of active levers before priming	0.4	0.4	0.6	-0.8	0.8	-0.1
Active lever presses in extinction session 6	0.1	0.1	0.2	-0.4	0.4	-0.2
Bone: final force	0.2	0.3	0.6	0.4	-0.4	-0.8
Bone: final moment	0.1	0.1	0.3	0.2	-0.2	-0.6
Food consumed during 24 hour testing period	0.3	0.4	1.0	0.2	-0.2	-1.0
Glucose	0.2	0.3	0.9	0.3	-0.3	0.9
Heart weight	2.7	3.9	5.8	2.4	-2.4	-0.2
Delay discount hyperbolic model param	0.1	0.1	0.2	0.0	-0.0	-0.4
Intermittent access intake day 1-15 change	1.6	1.5	2.3	-1.5	1.5	-0.1
Intermittent access intake escalation	1.5	1.5	2.3	-1.5	1.5	0.0
Intermittent access intake escalation 2	0.5	0.5	0.6	-0.8	0.8	0.5
Intermitt. access day 1 inactive lever presses	0.2	0.2	0.4	0.4	-0.4	-0.6
Intermitt. access day 15 inactive lever presses	0.3	0.4	0.4	-0.6	0.7	-0.5
Intermitt. access escalation Index	2.2	1.9	2.6	1.6	-1.6	-0.7
Intermittent access day 1 total infusions	1.0	1.1	1.2	-1.0	1.0	-1.1
Intermittent access day 15 total infusions	0.9	1.0	1.2	-1.1	1.1	-0.8
Intermittent access terminal intake (last 3 days)	1.1	1.2	2.9	-0.6	0.6	-1.7
Intermittent access total infusions	0.9	1.0	1.2	-1.0	0.9	-1.1
Intermittent access day 1 locomotion	0.9	0.9	2.2	-0.6	0.6	-1.5
Intermittent access day 15 total locomotion	0.4	0.4	1.2	0.1	-0.1	-1.1
Intermittent access total locomotion	0.3	0.4	0.9	-0.3	0.3	-0.9
Intermittent access standard deviation	0.1	0.1	0.2	-0.2	0.2	-0.5
Left kidney weight	0.1	0.4	1.1	-0.0	-0.0	-1.0
Right kidney weight	0.3	0.8	1.0	1.0	-1.0	-0.5
Cocaine induced anxiety	3.0	3.5	4.0	-2.0	2.0	1.6
Post-drug Anxiety	0.3	0.4	0.7	-0.4	0.4	0.8
Baseline Anxiety	2.7	2.9	3.8	1.9	-1.9	-1.0
Tail length	0.0	0.0	0.0	-0.0	0.0	-0.0
Length with tail	0.2	0.6	0.8	0.9	-0.9	0.3
Length without tail	0.0	0.1	0.1	-0.1	0.1	-0.4
Times rat made contact with spout	1.7	1.9	2.9	-1.7	1.7	0.1
Lifetime Intake	0.9	1.1	1.2	-1.0	1.0	-1.1
Liver weight, left	3.5	5.6	7.9	2.8	-2.8	-1.1
Liver weight, right	2.7	4.5	6.8	2.6	-2.6	-0.1
Locomotor activity	1.7	2.7	4.0	2.0	-2.0	0.1
Locomotor testing distance	1.1	1.9	2.4	1.6	-1.6	0.8
Locomotor testing rearing	0.2	0.3	0.5	0.7	-0.7	-0.2
Locomotion in novel chamber	1.9	2.4	3.6	1.9	-1.9	-0.2
Locomotion in novel chamber post-restriction	0.2	0.3	0.3	0.5	-0.5	-0.5
Fecal boli incidents, locomotor time 1	1.5	1.7	2.5	-1.6	1.6	0.0
Change in fecal boli incidents, locomotor task	1.3	1.2	1.4	1.2	-1.2	-0.9
Time >=10cm from walls, locomotor time 1	0.4	0.5	0.5	-0.6	0.6	0.7
Bouts of movement, locomotor time 1	0.1	0.1	0.1	-0.4	0.4	0.4
Total resting periods, locomotor time 1	0.6	0.7	0.7	-0.8	0.8	0.8
Rest time, locomotor task time 1	0.2	0.3	0.5	-0.4	0.4	0.7
Distance moved, locomotor task time 1	0.6	0.6	0.8	0.9	-0.9	-0.6
Vertical activity count, locomotor time 1	1.1	1.2	1.4	1.0	-1.0	-1.2
Time >=10cm from walls, locomotor time 2	1.7	1.8	2.4	-1.5	1.6	0.7
Bouts of movement, locomotor time 2	0.1	0.1	0.3	0.1	-0.1	0.6
Total resting periods, locomotor time 2	0.2	0.2	0.6	-0.2	0.2	0.8
Rest time, locomotor task time 2	0.5	0.5	1.5	-0.3	0.2	1.2
Distance moved, locomotor task time 2	1.0	1.1	2.7	0.6	-0.6	-1.6
Vertical activity count, locomotor time 2	0.3	0.3	0.8	0.1	-0.1	-0.9
Light reinforcement 1	0.0	0.0	0.1	0.1	-0.1	-0.3
Light reinforcement 2	1.0	1.3	1.4	-1.1	1.1	-1.2
Bone: marrow area	0.5	1.1	1.6	-1.3	1.3	0.1
Bone: maximum diameter	0.4	0.7	1.1	-1.0	1.0	0.1
Bone: maximum force	0.1	0.2	0.6	0.1	-0.1	-0.8
Bone: maximum moment	0.1	0.1	0.3	-0.1	0.1	-0.5
Mean time between licks in bursts	0.6	0.9	1.1	0.9	-0.9	1.0
Mean num. licks in bursts	3.2	3.9	5.8	-2.4	2.4	-0.4
Cd content in liver	0.0	0.0	0.0	-0.2	0.2	0.0
Co content in liver	1.5	1.8	4.0	-0.8	0.8	-2.0
Cu content in liver	0.5	0.6	1.3	0.5	-0.5	1.1
Fe content in liver	1.3	1.6	2.3	-1.5	1.5	0.5
K content in liver	0.9	0.9	1.4	1.2	-1.1	-0.1
Mg content in liver	0.4	0.4	0.6	0.7	-0.7	0.3
Mn content in liver	0.2	0.2	0.3	0.5	-0.5	-0.2
Na content in liver	1.3	1.3	2.9	-0.7	0.7	-1.7
Rb content in liver	0.0	0.0	0.0	-0.1	0.1	0.1
Se content in liver	0.3	0.4	0.5	0.7	-0.7	0.4
Sr content in liver	0.1	0.1	0.3	-0.1	0.1	0.6
Zn content in liver	3.6	4.0	5.9	2.4	-2.4	-0.4
Bone: minimum diameter	0.4	0.7	1.0	1.0	-1.0	0.2
Time in familiar zone, hab. session 1	1.2	1.1	1.6	1.3	-1.3	0.4
Time in novel zone, hab. session 1	0.3	0.3	0.6	-0.3	0.3	0.8
Total zone transitions, hab. session 1	0.2	0.3	0.4	-0.6	0.6	-0.3
Total locomotion distance, hab. session 1	0.3	0.4	0.8	-0.5	0.5	-0.9
Locomotion velocity, hab. session 1	0.8	1.1	2.7	-0.6	0.5	-1.6
Time in familiar zone, hab. session 2	0.3	0.3	0.8	0.2	-0.2	0.9
Time in novel zone, hab. session 2	0.3	0.3	1.0	0.0	-0.0	1.0
Total zone transitions, hab. session 2	0.4	0.5	0.7	-0.9	0.9	0.3
Total locomotion distance, hab. session 2	0.3	0.4	0.6	-0.8	0.8	0.2
Locomotion velocity, hab. session 2	0.3	0.5	0.7	-0.8	0.8	-0.0
Novel to familiar place preference ratio	0.0	0.0	0.0	-0.1	0.1	-0.2
Novelty place preference	0.1	0.1	0.2	0.4	-0.4	-0.3
Time in novel zone, NPP test	0.1	0.1	0.1	0.2	-0.2	0.3
Total zone transitions, NPP test	0.5	0.8	1.2	-1.1	1.1	0.1
Total locomotion distance, NPP test	1.1	1.5	2.3	-1.5	1.5	0.1
Locomotion velocity, NPP test	1.1	1.6	2.2	-1.5	1.5	-0.6
Intraocular pressure	1.5	2.1	2.8	1.3	-1.3	1.7
Delta distance traveled before/after self-admin	0.0	0.0	0.0	0.0	-0.1	0.1
Delta ambulatory time before/after self-admin	0.3	0.3	0.5	-0.7	0.7	0.1
Parametrial fat weight	12.2	23.8	35.5	6.0	-6.0	0.6
Pavlov. Cond. lever latency	0.1	0.1	0.1	0.3	-0.3	-0.1
Pavlov. Cond. magazine entry latency	0.4	0.5	1.2	-0.4	0.4	1.1
Pavlov. Cond. change in total contacts	0.4	0.4	1.2	-0.1	0.1	1.1
Pavlov. Cond. index score	0.2	0.2	0.3	-0.4	0.4	0.6
Pavlov. Cond. latency score	0.3	0.4	0.6	-0.6	0.6	0.8
Pavlov. Cond. lever contacts	0.2	0.2	0.3	-0.5	0.5	-0.0
Pavlov. Cond. magazine entry number	0.5	0.6	0.9	0.6	-0.6	-1.0
Pavlov. Cond. intertrial magazine entries	0.7	0.9	1.3	-1.1	1.1	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	0.6	-0.8	0.8	0.3
Pavlov. Cond. response bias	0.9	1.1	1.6	-1.3	1.3	0.4
Pavlov. Cond. lever latency	0.7	1.0	1.1	1.1	-1.1	0.9
Pavlov. Cond. magazine entry latency	0.0	0.1	0.1	-0.3	0.3	-0.2
Pavlov. Cond. change in total contacts	0.1	0.1	0.1	-0.3	0.3	-0.3
Pavlov. Cond. index score	0.5	0.7	1.0	-0.8	0.8	-1.0
Pavlov. Cond. latency score	0.6	0.8	0.8	-0.9	0.9	-0.9
Pavlov. Cond. lever contacts	0.3	0.4	0.9	-0.4	0.4	-0.9
Pavlov. Cond. magazine entry number	0.0	0.0	0.0	0.1	-0.1	-0.2
Pavlov. Cond. intertrial magazine entries	1.0	1.3	1.6	1.2	-1.2	0.8
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.5	-0.6	0.6	-0.7
Pavlov. Cond. response bias	0.4	0.5	0.6	-0.8	0.8	-0.6
Time in closed arm before self-admin	0.0	0.0	0.0	-0.1	0.1	0.1
Time in closed arm after self-admin	1.4	1.4	2.1	1.0	-1.0	-1.5
Time in open arm before self-admin	0.5	0.6	0.7	0.7	-0.7	-0.8
Time in open arm after self-admin	0.6	0.6	1.9	-0.0	0.0	1.4
Bone: periosteal estimation	0.3	0.7	1.0	-1.0	1.0	0.2
Bone: periosteal perimeter	0.1	0.1	0.2	-0.4	0.4	-0.2
Bone: post-yield work	1.2	1.7	2.5	-1.6	1.6	-0.1
Progressive ratio test 1 active lever presses	0.7	0.8	1.9	-0.5	0.4	-1.4
Progressive ratio test 1 breakpoint	0.7	0.8	1.7	-0.6	0.5	-1.3
Progressive ratio test 1 inactive lever presses	1.3	1.4	1.9	-1.1	1.1	-1.4
Progressive ratio test 2 active lever presses	0.7	0.8	1.1	-1.1	1.0	-0.4
Progressive ratio test 2 breakpoint	0.9	1.0	1.4	-1.2	1.2	-0.4
Progressive ratio test 2 inactive lever presses	1.4	1.6	1.9	-1.4	1.4	-1.1
Incentive Sensitization - Responses	0.2	0.2	0.2	-0.5	0.5	0.4
Incentive Sensitization - Breakpoint	0.0	0.1	0.1	-0.2	0.2	0.3
Sum of active levers in priming session hrs 5-6	0.7	0.7	0.7	-0.8	0.8	0.9
Progressive ratio	0.0	0.0	0.1	0.1	-0.0	-0.3
Food seeking constrained by brief footshock	5.0	6.2	9.3	-3.0	3.0	-0.1
Seeking ratio, punishment vs. effort	1.0	1.3	1.9	-1.4	1.4	0.0
Retroperitoneal fat weight	20.4	67.1	97.5	9.9	-9.9	2.6
Reaction time number correct	0.2	0.3	0.3	-0.5	0.6	0.5
Reaction time mean minus median	2.6	3.5	6.5	1.4	-1.4	2.6
Reaction time mean minus median AUC	2.2	2.8	3.7	1.5	-1.5	1.9
Reaction time num false alarms	0.5	0.7	1.1	0.7	-0.7	1.0
Reaction time num false alarms AUC	0.6	0.8	0.9	0.9	-0.9	0.9
Reaction time trials correct on left	0.2	0.3	0.3	-0.5	0.6	0.5
Reaction time trials on left	0.2	0.3	0.5	-0.4	0.4	0.7
Reaction time mean	1.7	2.4	5.8	0.8	-0.8	2.4
Reaction time mean AUC	1.4	1.9	4.5	0.8	-0.8	2.1
Median of all reaction times	1.1	1.5	4.1	0.4	-0.4	2.0
Reaction time omissions	2.7	3.7	8.9	1.1	-1.1	3.0
Reaction time false alarm rate	0.7	1.0	1.5	1.2	-1.2	0.2
Reaction time premature initiation rate	0.3	0.5	0.6	-0.8	0.8	-0.5
Reaction time premature initiations	0.6	0.8	1.2	-1.1	1.1	0.1
Std. dev. reaction times	2.9	4.1	9.1	1.3	-1.3	3.0
Reaction time trials completed	0.2	0.3	0.5	-0.4	0.4	0.7
Reaction time trials AUC	0.2	0.2	0.5	-0.3	0.3	0.7
Run reversals in cocaine runway, females	0.7	0.7	0.8	-0.9	0.9	-0.7
Run reversals in cocaine runway, males	0.7	0.7	1.9	-0.3	0.3	-1.4
Latency to leave start box in cocaine runway	3.5	3.7	3.9	-1.9	2.0	1.9
Latency to leave start box in cocaine runway, F	1.3	1.5	1.8	-1.3	1.3	0.9
Latency to leave start box in cocaine runway, M	3.3	3.1	3.5	-1.9	1.9	1.5
Std. dev. time between licks in bursts	0.3	0.3	1.0	-0.1	0.1	1.0
Total sessions with >9 infusions	1.5	1.6	4.0	-0.7	0.7	-2.0
Short access day 1 total inactive lever presses	1.0	1.2	1.2	-1.1	1.1	-1.1
Short access day 10 total inactive lever presses	0.7	0.8	2.1	-0.3	0.3	1.5
Short access day 1 total infusions	0.7	0.8	1.1	-1.0	1.0	-0.3
Short access day 10 total infusions	1.0	1.1	1.2	-1.0	1.0	-1.1
Short access total infusions	1.0	1.1	1.3	-1.2	1.1	-0.9
Short access day 1 locomotion	0.9	0.9	1.4	-1.2	1.2	-0.3
Short access day 10 total locomotion	0.3	0.3	0.5	-0.7	0.7	0.1
Short access total locomotion	0.8	0.9	1.0	-1.0	1.0	-0.8
One hour access (0.3 mA shock)	2.8	3.3	4.8	-2.2	2.2	0.5
Compulsive drug intake	0.5	0.5	1.3	-0.1	0.1	1.2
One hour access (shock baseline)	1.3	1.5	2.0	-1.4	1.4	-0.6
Social response proportion	0.5	0.5	1.4	0.3	-0.3	-1.2
Social responses	0.1	0.1	0.2	0.4	-0.4	0.4
Social time	0.5	0.6	0.7	0.8	-0.8	-0.8
Soleus weight	2.2	6.6	9.8	-3.1	3.1	-0.4
Bone: stiffness	0.4	0.7	1.8	0.4	-0.4	-1.4
Tibialis anterior weight	0.5	1.7	2.5	-1.6	1.6	0.2
Time to tail flick, vehicle, before self-admin	1.8	1.9	2.7	1.6	-1.7	0.4
Time to tail flick, vehicle, after self-admin	2.4	2.6	3.6	1.9	-1.9	0.8
Time to tail flick, test, before self-admin	0.7	0.7	0.9	-0.9	0.9	-0.7
Time to tail flick, test, after self-admin	0.2	0.2	0.3	-0.4	0.4	-0.6
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.4	0.1	-0.1	0.6
Delta time to tail flick, test, before/after SA	0.6	0.5	0.7	-0.8	0.8	-0.4
Tibia length	1.1	3.1	4.6	2.1	-2.1	-0.3
Ambulatory time before self-admin	0.5	0.5	0.6	0.8	-0.8	-0.5
Ambulatory time after self-admin	0.1	0.1	0.4	0.1	-0.1	-0.6
Bone: tissue strength	0.8	0.8	1.2	1.1	-1.1	-0.1
Total heroin consumption	1.3	1.6	2.3	-1.5	1.5	0.5
Bone: trabecular number	4.2	6.5	9.0	-3.0	3.0	1.3
Bone: trabecular spacing	2.8	3.6	4.4	2.1	-2.1	-1.4
Bone: trabecular thickness	3.6	4.3	5.6	-1.9	1.9	2.4
Bone: trabecular tissue density	0.1	0.2	0.2	-0.5	0.5	-0.4
Water consumed over 24 hours	0.9	1.1	1.2	-1.1	1.1	1.0
Number of responses in last shaping day	1.0	1.0	1.5	-1.2	1.2	0.2