Dnajc27

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	IC	gene expression	Dnajc27	0.24	0.13	3.3e-06	0.17	0.14	0.13	0.18	1.1e-07	1.6e-06	3.8e-06	5.3e-08
2	Brain	gene expression	Dnajc27	0.04	0.03	3.2e-04	0.04	0.03	0.03	0.04	1.7e-04	1.0e-03	6.4e-04	3.1e-04
3	Adipose	isoform ratio	XR_010052060.1	0.59	0.16	0.0e+00	0.23	0.22	0.24	0.23	9.1e-25	1.0e-23	2.7e-26	7.4e-25
4	Adipose	gene expression	Dnajc27	0.43	0.18	0.0e+00	0.3	0.31	0.31	0.31	3.3e-33	1.6e-34	5.5e-35	4.7e-35
5	NAcc	gene expression	Dnajc27	0.12	0.05	0.0e+00	0.14	0.14	0.14	0.14	1.5e-20	6.0e-21	1.3e-20	1.4e-20
6	LHb	gene expression	Dnajc27	0.64	0.22	6.1e-03	0.07	0.03	0.14	0.04	1.0e-02	8.0e-02	4.0e-04	3.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	2.5	4.2	5.8	-2.3	-2.4	2.3	-2.2	-2.1	0.0
Area under the delay curve	0.0	0.0	0.1	-0.2	-0.2	0.0	0.1	-0.1	-0.1
BMI with tail	2.7	9.3	11.4	3.3	3.1	-3.4	3.1	3.4	1.6
BMI without tail	2.7	8.1	10.0	3.2	3.0	-3.1	3.0	3.0	1.3
Body weight	2.6	11.2	14.8	3.8	3.3	-3.7	3.2	3.8	1.7
Weight adjusted by age	0.8	1.2	1.6	1.3	1.1	-1.2	0.7	0.9	1.2
Bone surface	0.4	0.7	1.0	-1.0	-0.8	0.9	-0.9	-0.9	-0.4
Bone volume	1.2	2.2	3.0	-1.7	-1.6	1.6	-1.6	-1.5	-0.5
Breakpoint value in progressive ratio session	0.5	0.6	0.9	-0.8	-0.9	0.7	-0.9	-0.9	-0.5
Number of licking bursts	1.1	1.9	2.3	1.3	1.5	-1.3	1.4	1.5	1.1
Context. condit. distance diff. score	0.2	0.2	0.3	-0.5	-0.5	0.5	-0.3	-0.5	0.3
Locomotion velocity, session 1	0.1	0.1	0.2	0.2	0.4	-0.1	0.4	0.4	-0.1
Locomotion distance, session 1	1.0	1.3	1.7	-1.2	-1.3	1.3	-1.3	-0.9	-0.8
Locomotion velocity, session 2	0.4	0.5	0.9	0.7	0.9	-0.7	0.6	0.7	-0.3
Locomotion distance, session 2	0.3	0.4	1.9	-0.3	-0.1	0.2	-0.4	0.1	-1.4
Locomotion velocity, session 3	0.1	0.1	0.6	0.0	-0.0	-0.0	0.1	0.0	0.8
Locomotion distance, session 3	0.0	0.0	0.0	0.1	0.1	-0.1	0.1	0.1	0.1
Stereotopy head waving bouts, day 3	1.8	2.1	3.3	-1.5	-1.4	1.5	-1.7	-1.8	-0.2
Stereotopy head waving duration, day 3	0.3	0.3	0.6	-0.5	-0.4	0.5	-0.5	-0.8	0.6
Locomotion velocity, session 7	0.0	0.0	0.1	0.2	-0.2	-0.1	0.1	0.1	-0.2
Locomotion distance, session 7	0.8	1.0	1.5	1.2	0.9	-1.2	1.2	1.0	0.1
Stereotopy head waving bouts, day 7	0.2	0.2	1.1	-0.3	-0.1	0.4	-0.0	-0.1	1.0
Stereotopy head waving duration, day 7	0.5	0.7	1.8	-0.7	-0.6	0.8	-0.6	-0.6	1.4
Locomotion velocity, session 8	0.3	0.4	0.6	-0.5	-0.5	0.5	-0.8	-0.6	-0.7
Locomotion distance, session 8	1.0	1.5	1.9	-1.4	-1.4	1.3	-1.0	-1.1	-1.2
Degree of sensitization distance	1.1	1.1	1.5	1.2	1.0	-1.2	1.2	1.1	0.5
Degree of sensitization stereotypy	0.4	0.5	1.6	0.3	0.5	-0.2	0.7	0.6	1.2
Conditioned locomotion	1.8	2.1	2.8	-1.5	-1.6	1.6	-1.5	-1.7	0.5
Cocaine response after cond. corrected	0.2	0.2	0.7	-0.3	-0.1	0.4	-0.3	-0.3	0.8
Cocaine response after cond. not corrected	0.5	0.6	0.8	-0.8	-0.6	0.9	-0.9	-0.9	0.5
Cocaine response before conditioning	1.5	1.8	2.5	-1.3	-1.2	1.4	-1.6	-1.6	-0.8
Saline control response	1.1	1.5	2.0	-1.3	-1.4	1.3	-1.3	-1.3	-0.3
Bone: connectivity density	1.2	1.9	2.6	-1.4	-1.6	1.6	-1.4	-1.4	0.4
Bone: cortical apparent density	0.1	0.2	0.7	-0.1	-0.3	0.2	-0.3	-0.4	-0.8
Bone: cortical area	0.0	0.0	0.0	0.1	0.0	0.1	-0.0	0.1	0.1
Bone: cortical porosity	1.8	2.0	3.1	-1.4	-1.5	1.4	-1.8	-1.6	0.2
Bone: cortical porosity	1.6	1.8	2.9	-1.3	-1.4	1.3	-1.7	-1.5	-0.2
Bone: cortical thickness	0.1	0.2	0.3	0.5	0.4	-0.3	0.4	0.5	-0.3
Bone: cortical thickness	0.6	0.7	1.5	-0.7	-0.8	0.6	-0.9	-0.7	-1.2
Bone: cortical tissue density	0.1	0.1	0.7	-0.0	-0.2	0.1	-0.2	-0.3	-0.8
Condit. Reinf. active minus inactive responses	2.4	2.7	3.7	1.9	1.7	-1.8	1.7	1.9	0.3
Condit. Reinf. active-inactive response ratio	2.7	2.9	4.3	2.1	1.8	-1.9	1.7	1.6	0.5
Condit. Reinf. active responses	0.2	0.3	0.5	0.6	0.5	-0.5	0.4	0.7	-0.2
Condit. Reinf. inactive responses	1.6	2.0	2.8	-1.7	-1.5	1.5	-1.5	-1.1	-1.0
Incentive salience index mean	0.6	0.7	1.0	1.0	0.8	-0.8	0.7	1.0	0.7
Condit. Reinf. lever presses	0.6	0.8	1.3	-0.9	-0.9	1.1	-1.1	-0.7	0.5
Condit. Reinf. active minus inactive responses	0.5	0.7	1.1	-0.9	-0.8	0.8	-1.0	-1.0	0.1
Condit. Reinf. active-inactive response ratio	0.3	0.4	0.9	-0.4	-0.5	0.5	-0.6	-0.5	1.0
Condit. Reinf. active responses	0.4	0.6	0.8	-0.9	-0.7	0.8	-0.9	-0.7	0.0
Condit. Reinf. inactive responses	0.2	0.2	0.4	-0.6	-0.4	0.6	-0.5	-0.3	-0.4
Condit. Reinf. lever presses	0.8	1.1	1.5	-1.2	-1.0	1.1	-1.2	-1.2	-0.4
Condit. Reinf. lever reinforcers received	0.3	0.4	0.7	-0.7	-0.7	0.7	-0.9	-0.7	-0.1
Conditioned reinforcement - actives	3.0	5.1	6.7	-2.2	-2.4	2.3	-2.6	-2.5	-1.3
Conditioned reinforcement - inactives	5.4	7.9	10.1	-3.0	-3.1	3.2	-3.0	-3.1	-0.5
Conditioned locomotion	2.6	3.4	4.9	-1.6	-2.1	1.3	-2.0	-1.7	-2.2
Patch foraging indifference point 0 sec	0.2	0.3	1.1	0.5	-0.0	-0.3	0.4	0.5	-1.0
Patch foraging indifference point AUC	0.2	0.3	1.4	-0.3	-0.1	0.2	0.1	-0.2	1.2
Delay disc. indifference point, 0s delay	0.1	0.1	0.5	0.2	0.3	-0.2	0.7	0.3	-0.0
Delay disc. indifference point, 16s delay	0.0	0.0	0.0	-0.1	0.1	-0.1	0.1	0.0	0.0
Delay disc. indifference point, 2s delay	0.2	0.3	1.4	0.1	0.1	-0.4	0.4	0.1	-1.2
Delay disc. indifference point, 24s delay	2.4	2.7	4.3	-1.9	-2.1	1.5	-1.8	-1.6	-0.3
Delay disc. indifference point, 4s delay	0.2	0.2	1.0	0.2	0.3	-0.3	0.4	0.1	-1.0
Delay disc. indifference point, 8s delay	0.0	0.0	0.1	-0.2	-0.3	-0.0	-0.0	-0.1	-0.2
Indifference point function ln k	1.3	2.3	3.0	-1.6	-1.7	1.7	-1.6	-1.6	-0.4
Indifference point function log k	1.3	2.3	3.0	-1.6	-1.7	1.7	-1.6	-1.6	-0.4
Patch foraging total patch changes 0 sec	0.2	0.3	1.3	0.5	-0.0	-0.3	0.3	0.5	-1.1
Patch foraging total patch changes 12 sec	1.5	1.9	2.2	1.5	1.1	-1.4	1.4	1.4	1.5
Patch foraging total patch changes 18 sec	0.4	0.6	0.8	0.8	0.9	-0.9	0.8	0.9	-0.4
Patch foraging total patch changes 24 sec	0.5	0.8	1.3	0.8	1.0	-0.8	1.1	1.1	0.2
Patch foraging total patch changes 6 sec	0.9	1.4	2.1	1.3	1.0	-1.3	1.4	1.4	0.5
Patch foraging time to switch 0 sec	0.7	1.4	2.0	1.3	1.3	-1.4	1.3	1.1	0.3
Patch foraging water rate 0 sec	2.3	4.9	6.2	-2.3	-2.5	2.2	-2.3	-2.0	-1.9
Patch foraging water rate 12 sec	0.0	0.0	0.0	-0.0	-0.2	0.1	0.0	0.1	-0.1
Patch foraging water rate 18 sec	2.7	4.1	5.2	-2.2	-2.2	2.3	-2.0	-1.9	-1.5
Patch foraging water rate 24 sec	0.1	0.2	0.3	0.6	0.3	-0.6	0.3	0.4	-0.5
Patch foraging water rate 6 sec	1.1	1.6	2.2	-1.2	-1.2	1.3	-1.2	-1.1	-1.5
Seeking ratio, delayed vs. immediate footshock	0.5	0.6	0.9	0.8	0.9	-0.9	0.6	0.5	0.5
Distance traveled before self-admin	0.1	0.1	0.2	-0.4	-0.3	0.1	-0.4	-0.2	-0.3
Distance traveled after self-admin	0.3	0.3	0.7	0.4	0.5	-0.4	0.7	0.5	-0.8
Extensor digitorum longus weight	2.0	7.9	10.5	-3.0	-3.2	3.0	-3.2	-2.9	0.6
Bone: elastic displacement	1.6	1.8	2.3	-1.5	-1.4	1.5	-1.5	-1.5	-0.1
Bone: elastic work	1.0	1.3	1.5	-1.1	-1.2	1.2	-1.0	-1.2	-0.9
Bone: endosteal estimation	0.2	0.5	1.0	-1.0	-0.7	0.8	-0.8	-0.6	-0.1
Bone: endosteal perimeter	0.1	0.1	0.8	-0.1	0.1	0.1	-0.1	0.1	0.9
Epididymis fat weight	18.3	62.7	78.7	8.9	8.3	-8.7	8.3	8.7	2.9
Delta time in closed arm before/after self-admin	0.0	0.0	0.1	0.2	0.0	-0.2	0.3	0.1	0.0
Delta time in open arm before/after self-admin	0.4	0.4	1.9	0.2	0.3	-0.3	0.1	0.5	1.4
Diff in mean of infusions in LGA sessions	0.7	0.8	2.3	0.8	0.8	-0.8	0.6	0.7	1.5
Delay discount exponential model param	0.1	0.1	0.2	0.5	0.5	-0.2	0.2	0.4	0.4
Extinction: sum of active levers before priming	0.1	0.1	0.5	-0.1	-0.2	0.1	-0.2	-0.2	0.7
Active lever presses in extinction session 6	2.0	2.0	6.2	-0.9	-1.4	1.1	-1.1	-0.8	2.5
Bone: final force	0.2	0.2	0.9	0.5	0.2	-0.2	0.3	0.4	0.9
Bone: final moment	0.1	0.2	0.7	0.3	0.1	-0.1	0.2	0.2	0.8
Food consumed during 24 hour testing period	0.1	0.1	0.2	-0.5	-0.3	0.4	-0.2	-0.2	-0.5
Glucose	0.9	1.5	1.8	1.2	1.2	-1.4	1.3	1.2	0.8
Heart weight	0.9	1.5	2.4	1.1	1.5	-1.3	1.5	1.2	0.1
Delay discount hyperbolic model param	0.1	0.1	0.3	0.2	0.2	0.1	-0.1	0.1	0.5
Intermittent access intake day 1-15 change	1.8	3.7	5.9	-1.9	-1.6	1.9	-1.7	-1.9	-2.4
Intermittent access intake escalation	1.5	3.0	6.4	-1.6	-1.3	1.7	-1.3	-1.6	-2.5
Intermittent access intake escalation 2	1.7	1.9	5.9	-1.2	-0.7	1.1	-0.9	-1.2	-2.4
Intermitt. access day 1 inactive lever presses	0.4	1.4	2.0	-1.1	-1.4	1.2	-1.0	-0.9	1.3
Intermitt. access day 15 inactive lever presses	0.6	1.2	2.4	-0.8	-0.9	1.1	-1.0	-1.1	1.5
Intermitt. access escalation Index	3.4	4.8	7.6	2.2	2.8	-2.3	2.5	1.9	-0.4
Intermittent access day 1 total infusions	1.2	1.9	2.2	-1.3	-1.3	1.5	-1.3	-1.3	1.5
Intermittent access day 15 total infusions	2.3	3.4	4.7	-2.1	-1.8	2.2	-1.9	-2.1	-0.7
Intermittent access terminal intake (last 3 days)	3.8	5.0	6.5	-2.5	-2.3	2.6	-2.2	-2.4	-1.2
Intermittent access total infusions	3.0	3.5	5.3	-2.0	-2.3	2.0	-2.1	-1.9	0.2
Intermittent access day 1 locomotion	2.2	2.8	3.7	-1.9	-1.8	1.9	-1.8	-1.7	-0.1
Intermittent access day 15 total locomotion	0.4	0.8	1.4	-0.8	-1.0	0.9	-0.7	-0.6	-1.2
Intermittent access total locomotion	2.1	2.6	3.9	-1.7	-2.0	1.6	-1.7	-1.4	-1.2
Intermittent access standard deviation	1.4	3.0	3.9	-2.0	-1.9	1.9	-1.8	-1.7	-0.7
Left kidney weight	0.2	0.9	5.1	0.2	-0.1	-0.1	-0.4	-0.0	2.3
Right kidney weight	0.6	2.7	6.1	1.8	1.3	-1.6	1.0	1.4	2.5
Cocaine induced anxiety	0.1	0.1	0.3	-0.2	-0.3	0.5	-0.4	-0.5	-0.1
Post-drug Anxiety	0.9	0.9	1.4	1.0	1.0	-0.8	1.1	1.2	0.6
Baseline Anxiety	2.4	2.8	4.2	1.7	1.8	-1.7	1.9	2.1	0.2
Tail length	0.1	0.3	0.6	-0.4	-0.5	0.8	-0.6	-0.6	-0.2
Length with tail	0.1	0.3	0.8	0.9	0.3	-0.6	0.1	0.8	0.1
Length without tail	0.1	0.3	0.6	0.6	-0.1	-0.5	-0.2	0.7	0.8
Times rat made contact with spout	1.0	1.1	1.7	-1.1	-1.0	1.1	-1.3	-1.0	-0.9
Lifetime Intake	3.1	3.8	5.5	-2.1	-2.3	2.1	-2.2	-2.0	0.2
Liver weight, left	1.6	2.6	3.5	1.8	1.9	-1.5	1.7	1.7	1.0
Liver weight, right	3.1	5.4	6.5	2.5	2.4	-2.4	2.4	2.6	1.4
Locomotor activity	2.1	3.4	8.5	1.7	1.4	-1.4	1.3	1.7	2.9
Locomotor testing distance	1.4	2.5	6.7	1.5	1.4	-1.0	1.2	1.4	2.6
Locomotor testing rearing	0.3	0.6	3.4	0.3	-0.2	-0.0	-0.2	0.1	1.8
Locomotion in novel chamber	1.0	1.3	3.9	1.0	0.5	-0.9	0.7	1.1	2.0
Locomotion in novel chamber post-restriction	1.1	1.8	2.6	1.3	1.6	-1.3	1.5	1.3	-0.7
Fecal boli incidents, locomotor time 1	2.5	3.6	4.5	-2.1	-2.1	2.1	-1.9	-2.0	-0.8
Change in fecal boli incidents, locomotor task	4.5	4.4	6.6	2.6	2.3	-2.5	2.1	1.9	-0.6
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.6	-0.3	-0.7	0.4	-0.8	-0.5	-0.5
Bouts of movement, locomotor time 1	0.8	0.9	2.0	-0.7	-0.9	1.2	-0.4	-0.5	-1.4
Total resting periods, locomotor time 1	0.9	1.0	2.7	-0.8	-0.9	1.2	-0.5	-0.5	-1.6
Rest time, locomotor task time 1	0.1	0.2	0.9	-0.0	-0.2	0.3	0.3	-0.1	-1.0
Distance moved, locomotor task time 1	0.6	1.0	2.6	0.8	0.9	-1.0	0.4	0.8	1.6
Vertical activity count, locomotor time 1	0.0	0.1	0.3	0.2	0.5	-0.3	0.1	0.3	0.1
Time >=10cm from walls, locomotor time 2	0.7	1.0	2.0	-0.9	-1.0	0.8	-1.2	-1.4	-0.3
Bouts of movement, locomotor time 2	0.5	0.8	4.8	-0.1	-0.3	0.2	0.3	0.1	-2.2
Total resting periods, locomotor time 2	0.3	0.5	3.0	-0.1	-0.2	0.2	0.4	0.2	-1.7
Rest time, locomotor task time 2	0.1	0.1	0.3	-0.2	-0.4	0.5	-0.1	-0.1	0.1
Distance moved, locomotor task time 2	0.1	0.1	0.2	0.1	0.1	-0.5	0.1	0.0	0.4
Vertical activity count, locomotor time 2	0.0	0.0	0.2	0.0	0.1	-0.1	-0.0	-0.4	0.0
Light reinforcement 1	0.4	1.1	1.6	-1.0	-0.9	1.3	-1.0	-1.1	0.8
Light reinforcement 2	1.5	2.3	3.5	-1.6	-1.2	1.5	-1.4	-1.9	-1.4
Bone: marrow area	0.2	0.5	0.9	-1.0	-0.7	0.8	-0.7	-0.6	-0.2
Bone: maximum diameter	0.1	0.1	0.2	-0.4	-0.3	0.5	-0.4	-0.2	0.0
Bone: maximum force	0.0	0.0	0.1	0.0	-0.1	0.1	-0.1	-0.0	0.3
Bone: maximum moment	0.0	0.0	0.1	-0.1	-0.2	0.3	-0.2	-0.2	0.3
Mean time between licks in bursts	0.4	1.1	2.0	1.0	1.1	-1.0	1.4	1.1	-0.1
Mean num. licks in bursts	2.0	3.2	3.5	-1.8	-1.8	1.7	-1.9	-1.8	-1.6
Cd content in liver	0.3	0.4	0.7	0.8	0.7	-0.7	0.4	0.6	-0.1
Co content in liver	2.6	3.1	4.9	-1.8	-2.0	1.7	-2.2	-1.8	0.1
Cu content in liver	0.1	0.2	0.7	0.2	0.4	-0.3	0.0	0.2	0.8
Fe content in liver	1.9	2.3	3.3	-1.6	-1.8	1.5	-1.8	-1.5	-0.6
K content in liver	0.8	0.8	1.1	0.8	0.9	-0.8	0.8	0.9	1.1
Mg content in liver	0.0	0.0	0.1	0.1	0.3	-0.2	0.3	0.1	0.3
Mn content in liver	0.6	0.7	0.9	0.8	0.7	-1.0	0.9	0.8	-0.8
Na content in liver	2.8	3.0	4.2	-1.9	-1.9	2.1	-1.6	-1.9	0.8
Rb content in liver	0.3	0.3	0.5	0.7	0.6	-0.6	0.5	0.6	0.3
Se content in liver	0.3	0.3	0.6	0.7	0.7	-0.8	0.4	0.6	0.0
Sr content in liver	0.6	0.5	2.4	-0.4	-0.4	0.3	-0.5	-0.5	-1.5
Zn content in liver	1.6	1.8	2.8	1.3	1.7	-1.3	1.3	1.3	1.0
Bone: minimum diameter	0.8	1.4	1.9	1.3	1.4	-1.2	1.1	1.3	0.7
Time in familiar zone, hab. session 1	1.4	1.4	1.9	1.3	1.3	-1.4	1.2	1.2	0.3
Time in novel zone, hab. session 1	0.4	0.4	0.7	0.8	0.6	-0.7	0.5	0.6	-0.0
Total zone transitions, hab. session 1	0.8	1.1	1.9	-1.2	-1.4	1.3	-1.0	-0.7	-0.2
Total locomotion distance, hab. session 1	1.3	1.9	2.7	-1.5	-1.6	1.7	-1.5	-1.2	-0.4
Locomotion velocity, hab. session 1	2.5	3.5	5.0	-2.0	-2.1	2.2	-2.0	-1.8	-0.6
Time in familiar zone, hab. session 2	0.3	0.3	0.4	0.5	0.6	-0.6	0.7	0.3	-0.6
Time in novel zone, hab. session 2	0.3	0.3	0.5	0.7	0.6	-0.7	0.3	0.6	0.5
Total zone transitions, hab. session 2	0.3	0.4	0.8	-0.6	-0.5	0.7	-0.4	-0.1	-0.9
Total locomotion distance, hab. session 2	0.2	0.2	0.6	-0.5	-0.2	0.5	-0.4	0.1	-0.8
Locomotion velocity, hab. session 2	0.2	0.3	0.5	-0.7	-0.4	0.7	-0.5	-0.0	-0.5
Novel to familiar place preference ratio	0.0	0.0	0.2	0.0	-0.1	0.2	-0.1	0.2	-0.4
Novelty place preference	0.1	0.1	0.2	0.3	0.1	-0.1	0.1	0.5	-0.2
Time in novel zone, NPP test	0.1	0.2	0.4	0.5	0.3	-0.3	0.2	0.6	-0.2
Total zone transitions, NPP test	0.9	1.3	1.8	-1.3	-1.2	1.4	-1.3	-0.9	-0.0
Total locomotion distance, NPP test	1.6	2.2	3.0	-1.7	-1.5	1.7	-1.7	-1.3	-0.5
Locomotion velocity, NPP test	2.4	3.4	4.8	-2.2	-2.0	2.2	-2.0	-1.7	-0.0
Intraocular pressure	3.6	5.2	7.1	2.6	2.3	-2.7	2.4	2.4	-0.7
Delta distance traveled before/after self-admin	1.1	1.1	2.1	1.1	1.3	-0.7	1.5	1.0	0.6
Delta ambulatory time before/after self-admin	0.1	0.1	0.3	0.1	0.3	0.1	0.6	0.1	-0.5
Parametrial fat weight	25.3	59.5	68.3	8.1	8.1	-7.6	8.3	7.9	6.2
Pavlov. Cond. lever latency	0.4	0.5	0.7	0.7	0.7	-0.8	0.7	0.5	-0.7
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	-0.1	-0.1	0.1	-0.1	0.2	0.0
Pavlov. Cond. change in total contacts	0.1	0.1	0.1	-0.2	-0.4	0.3	-0.1	-0.1	-0.3
Pavlov. Cond. index score	0.1	0.1	0.1	-0.3	-0.3	0.3	-0.3	-0.1	0.2
Pavlov. Cond. latency score	0.0	0.1	0.1	-0.3	-0.3	0.3	-0.2	-0.0	0.1
Pavlov. Cond. lever contacts	0.4	0.5	0.6	-0.7	-0.7	0.8	-0.6	-0.5	0.7
Pavlov. Cond. magazine entry number	0.2	0.3	0.5	0.5	0.7	-0.7	0.5	0.2	0.0
Pavlov. Cond. intertrial magazine entries	0.5	0.6	1.2	-0.7	-0.6	0.6	-1.0	-1.1	-0.0
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.3	0.5	-0.6	-0.6	0.7	-0.6	-0.4	0.3
Pavlov. Cond. response bias	0.7	0.9	1.3	-0.9	-1.1	1.1	-1.0	-0.8	0.3
Pavlov. Cond. lever latency	0.6	0.8	1.0	1.0	0.9	-0.9	0.8	0.9	1.0
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	0.0	0.1	-0.2	0.2	0.1	0.0
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	-0.3	-0.2	0.0	-0.1	-0.1	-0.1
Pavlov. Cond. index score	0.3	0.4	0.5	-0.7	-0.6	0.5	-0.5	-0.7	-0.5
Pavlov. Cond. latency score	0.3	0.4	0.6	-0.8	-0.7	0.5	-0.6	-0.7	-0.6
Pavlov. Cond. lever contacts	0.3	0.4	0.5	-0.7	-0.6	0.6	-0.5	-0.6	-0.7
Pavlov. Cond. magazine entry number	0.2	0.2	0.4	-0.4	-0.5	0.6	-0.5	-0.5	-0.2
Pavlov. Cond. intertrial magazine entries	1.3	2.0	2.4	1.4	1.5	-1.3	1.2	1.4	-1.5
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.4	-0.4	-0.4	0.2	-0.3	-0.4	-0.6
Pavlov. Cond. response bias	0.4	0.6	0.9	-1.0	-0.9	0.8	-0.7	-0.8	-0.5
Time in closed arm before self-admin	0.1	0.1	0.3	0.4	0.1	-0.1	0.0	0.5	-0.3
Time in closed arm after self-admin	0.9	0.9	1.6	1.2	0.9	-1.0	0.7	1.2	0.6
Time in open arm before self-admin	0.1	0.1	0.2	-0.1	-0.1	-0.3	0.2	-0.0	-0.4
Time in open arm after self-admin	0.1	0.1	0.2	-0.5	-0.2	0.3	-0.3	-0.4	0.0
Bone: periosteal estimation	0.2	0.4	0.7	-0.9	-0.7	0.7	-0.7	-0.6	-0.1
Bone: periosteal perimeter	0.1	0.1	0.4	-0.1	-0.1	0.3	-0.2	-0.0	0.7
Bone: post-yield work	1.1	1.6	2.4	-1.4	-1.4	1.2	-1.5	-1.4	-0.4
Progressive ratio test 1 active lever presses	1.8	2.2	3.1	-1.5	-1.8	1.5	-1.5	-1.4	1.1
Progressive ratio test 1 breakpoint	1.8	2.2	3.2	-1.5	-1.8	1.5	-1.5	-1.4	1.0
Progressive ratio test 1 inactive lever presses	2.7	3.9	4.9	-1.8	-2.2	2.0	-2.0	-1.9	1.9
Progressive ratio test 2 active lever presses	3.4	4.0	4.9	-2.1	-2.2	2.0	-2.2	-2.1	-1.1
Progressive ratio test 2 breakpoint	3.4	3.9	4.6	-2.1	-2.1	2.0	-2.1	-2.1	-1.2
Progressive ratio test 2 inactive lever presses	3.1	5.1	6.3	-2.4	-2.5	2.4	-2.4	-2.4	-1.0
Incentive Sensitization - Responses	2.3	3.2	4.0	-1.8	-1.7	1.6	-1.9	-2.0	-1.7
Incentive Sensitization - Breakpoint	2.1	2.8	3.5	-1.6	-1.5	1.5	-1.7	-1.9	-1.8
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.1	0.0	0.3	0.0	0.1	0.2	-0.0
Progressive ratio	0.1	0.1	0.3	0.2	0.5	-0.3	0.2	0.3	0.1
Food seeking constrained by brief footshock	8.2	10.0	14.1	-3.4	-3.5	3.3	-3.8	-3.4	0.3
Seeking ratio, punishment vs. effort	1.5	2.1	3.0	-1.5	-1.7	1.5	-1.5	-1.6	-0.6
Retroperitoneal fat weight	39.6	169.0	205.4	14.3	14.0	-14.1	13.9	13.8	5.6
Reaction time number correct	0.3	0.6	0.8	-0.9	-0.8	0.9	-0.9	-0.6	-0.6
Reaction time mean minus median	0.7	1.8	2.4	1.5	1.5	-1.5	0.9	1.2	1.4
Reaction time mean minus median AUC	0.6	1.4	2.1	1.2	1.5	-1.1	0.9	1.2	1.3
Reaction time num false alarms	1.6	2.3	3.1	1.7	1.6	-1.6	1.5	1.8	0.8
Reaction time num false alarms AUC	1.4	2.1	2.9	1.6	1.5	-1.4	1.4	1.7	1.0
Reaction time trials correct on left	0.3	0.6	0.8	-0.9	-0.8	0.9	-0.9	-0.6	-0.6
Reaction time trials on left	0.3	0.5	0.7	-0.8	-0.7	0.8	-0.9	-0.6	-0.5
Reaction time mean	0.3	0.5	1.2	0.7	1.1	-0.7	0.7	0.5	0.2
Reaction time mean AUC	0.2	0.3	0.8	0.5	0.9	-0.5	0.5	0.4	0.3
Median of all reaction times	0.1	0.1	0.4	0.2	0.6	-0.2	0.3	0.0	-0.3
Reaction time omissions	1.0	1.5	3.7	1.1	0.9	-0.8	0.8	1.4	1.9
Reaction time false alarm rate	2.2	3.0	3.8	2.0	1.8	-1.8	1.8	1.9	0.9
Reaction time premature initiation rate	0.2	0.2	1.5	-0.1	-0.1	0.0	-0.0	0.1	-1.2
Reaction time premature initiations	0.3	0.5	1.7	-0.6	-0.5	0.6	-0.5	-0.4	-1.3
Std. dev. reaction times	0.9	1.7	2.6	1.4	1.6	-1.3	1.0	1.3	1.0
Reaction time trials completed	0.3	0.5	0.7	-0.8	-0.7	0.8	-0.9	-0.6	-0.5
Reaction time trials AUC	0.2	0.4	0.7	-0.7	-0.7	0.7	-0.8	-0.5	-0.3
Run reversals in cocaine runway, females	0.9	0.9	1.1	-0.9	-1.1	1.0	-0.9	-0.9	-0.8
Run reversals in cocaine runway, males	1.0	1.0	1.8	-1.0	-1.0	1.3	-1.1	-1.1	0.4
Latency to leave start box in cocaine runway	0.1	0.1	0.3	-0.3	-0.3	0.1	-0.3	-0.6	-0.3
Latency to leave start box in cocaine runway, F	0.2	0.2	0.4	0.6	0.5	-0.6	0.5	0.2	0.3
Latency to leave start box in cocaine runway, M	0.9	0.8	1.1	-0.9	-1.0	0.8	-0.8	-1.1	-0.7
Std. dev. time between licks in bursts	0.2	0.3	0.5	0.5	0.4	-0.5	0.7	0.6	-0.6
Total sessions with >9 infusions	2.4	3.0	4.2	-1.9	-2.0	1.7	-1.9	-1.7	-0.8
Short access day 1 total inactive lever presses	4.6	6.0	9.3	-2.8	-2.4	3.0	-2.5	-2.7	-0.0
Short access day 10 total inactive lever presses	0.5	1.2	4.1	-0.6	-0.6	1.2	-0.6	-0.8	2.0
Short access day 1 total infusions	2.2	2.9	3.9	-1.7	-2.0	1.8	-1.9	-1.8	0.8
Short access day 10 total infusions	2.1	2.7	3.8	-1.7	-1.7	1.8	-1.7	-1.9	0.5
Short access total infusions	1.5	1.9	2.7	-1.4	-1.6	1.4	-1.4	-1.4	0.7
Short access day 1 locomotion	1.5	1.9	3.0	-1.3	-1.7	1.4	-1.7	-1.1	0.5
Short access day 10 total locomotion	1.2	2.1	2.8	-1.7	-1.6	1.6	-1.5	-1.5	-0.4
Short access total locomotion	2.0	2.4	3.6	-1.8	-1.9	1.4	-1.5	-1.3	-1.1
One hour access (0.3 mA shock)	4.3	5.0	5.3	-2.2	-2.3	2.1	-2.2	-2.3	-2.3
Compulsive drug intake	1.3	1.5	3.1	0.8	1.5	-0.8	1.4	0.7	-1.8
One hour access (shock baseline)	4.0	6.1	8.9	-2.5	-3.0	2.5	-2.8	-2.6	-0.9
Social response proportion	0.3	0.3	0.8	0.7	0.3	-0.9	0.3	0.3	-0.6
Social responses	0.5	0.6	1.0	1.0	0.5	-1.0	0.8	0.8	0.4
Social time	0.1	0.1	0.2	0.3	0.1	-0.4	0.2	0.1	0.3
Soleus weight	3.7	10.8	13.5	-3.7	-3.6	3.7	-3.5	-3.4	-1.1
Bone: stiffness	0.0	0.0	0.1	0.1	-0.0	0.0	0.3	0.2	0.1
Tibialis anterior weight	1.2	4.2	5.6	-2.3	-2.4	2.3	-2.2	-2.1	-0.0
Time to tail flick, vehicle, before self-admin	0.5	0.5	2.7	0.2	-0.2	-0.0	-0.1	0.5	1.6
Time to tail flick, vehicle, after self-admin	5.4	7.2	9.3	3.0	2.4	-3.1	2.7	3.0	1.5
Time to tail flick, test, before self-admin	0.3	0.3	0.5	-0.4	-0.7	0.3	-0.7	-0.2	-0.7
Time to tail flick, test, after self-admin	0.9	0.9	1.3	-1.1	-1.0	0.8	-1.0	-1.1	-0.1
Delta time to tail flick, vehicle, before/after SA	1.9	1.8	2.4	1.5	1.4	-1.5	1.6	1.4	-0.2
Delta time to tail flick, test, before/after SA	1.5	1.6	3.3	-1.4	-1.1	1.2	-1.1	-1.8	-0.3
Tibia length	0.5	1.4	2.1	1.4	1.1	-1.1	1.2	1.5	0.1
Ambulatory time before self-admin	0.0	0.1	0.2	-0.4	-0.2	0.2	-0.4	-0.2	0.1
Ambulatory time after self-admin	0.0	0.1	0.2	0.0	0.3	0.1	0.4	0.1	-0.1
Bone: tissue strength	0.4	0.4	0.8	0.7	0.5	-0.5	0.9	0.6	0.6
Total heroin consumption	4.2	4.9	6.7	-2.6	-2.5	2.0	-2.2	-2.2	-1.6
Bone: trabecular number	2.2	3.6	5.1	-2.1	-2.3	2.1	-2.0	-2.0	0.2
Bone: trabecular spacing	0.2	0.3	0.5	0.5	0.6	-0.5	0.7	0.7	0.1
Bone: trabecular thickness	0.0	0.0	0.2	0.0	0.0	-0.1	-0.2	-0.2	0.4
Bone: trabecular tissue density	0.1	0.1	0.2	-0.3	-0.1	0.4	-0.4	-0.4	-0.2
Water consumed over 24 hours	0.0	0.1	0.2	0.0	0.1	-0.1	0.0	0.4	-0.4
Number of responses in last shaping day	0.9	0.9	1.3	-1.0	-1.1	0.9	-1.1	-1.1	0.3