Dnajc27

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	Dnajc27	0.19	0.04	7.8e-16	0.14	0.14	0.14	0.14	3.3e-16	4.8e-16	3.1e-16	2.3e-16
2	Brain	gene expression	Dnajc27	0.04	0.03	4.6e-04	0.03	0.02	0.02	0.02	1.5e-03	3.4e-03	9.1e-03	4.9e-03
3	Adipose	gene expression	Dnajc27	0.58	0.01	0.0e+00	0.31	0.33	0.33	0.33	2.2e-35	2.3e-37	8.0e-38	1.5e-37
4	Adipose	mRNA stability	Dnajc27	0.04	0.05	4.6e-03	0.01	0.02	0.01	0.01	7.5e-03	5.8e-03	1.0e-02	1.0e-02
5	Adipose	isoform ratio	XM_039111917.1	0.06	0.08	7.3e-03	0.01	0	0	0.01	2.3e-02	8.7e-02	2.0e-01	4.2e-02
6	LHb	gene expression	Dnajc27	0.68	0.19	2.9e-03	0.06	0.04	0.06	0.05	1.9e-02	5.1e-02	1.2e-02	2.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	3.4	5.7	7.3	-2.5	2.7	2.5	-2.6	2.3	1.4
Area under the delay curve	0.1	0.1	0.2	0.1	-0.1	-0.4	0.2	-0.5	0.1
BMI with tail	3.1	10.1	13.8	3.7	-3.2	-3.3	3.0	-3.1	-2.6
BMI without tail	1.0	2.0	5.3	1.7	-0.9	-1.0	1.0	-1.1	-2.3
Body weight	2.6	11.0	15.9	4.0	-3.5	-3.3	3.0	-2.8	-3.2
Weight adjusted by age	1.6	1.8	4.3	1.4	-1.5	-1.1	0.8	-0.8	-2.1
Bone surface	0.9	1.6	2.0	-1.3	1.3	1.3	-1.2	1.1	1.4
Bone volume	2.1	3.6	4.6	-2.0	2.1	1.9	-1.9	1.8	1.6
Breakpoint value in progressive ratio session	1.1	1.2	1.5	-1.1	1.1	1.0	-1.0	1.2	1.1
Number of licking bursts	1.5	1.8	2.2	1.4	-1.5	-1.2	1.2	-1.3	-1.4
Context. condit. distance diff. score	0.1	0.1	0.2	-0.4	0.4	0.1	-0.4	0.1	0.2
Locomotion velocity, session 1	0.2	0.2	0.4	0.4	-0.4	-0.2	0.6	-0.6	-0.2
Locomotion distance, session 1	0.9	1.1	1.6	-1.1	1.1	1.3	-1.0	1.2	0.1
Locomotion velocity, session 2	0.4	0.4	0.8	0.9	-0.8	-0.7	0.4	-0.5	-0.4
Locomotion distance, session 2	0.0	0.1	0.2	-0.1	0.1	0.4	-0.0	0.5	-0.0
Locomotion velocity, session 3	0.0	0.0	0.1	0.0	0.1	-0.1	-0.1	-0.2	-0.4
Locomotion distance, session 3	0.0	0.0	0.0	0.0	-0.0	-0.0	0.1	-0.1	0.0
Stereotopy head waving bouts, day 3	2.0	2.3	3.0	-1.7	1.5	1.5	-1.4	1.5	1.5
Stereotopy head waving duration, day 3	0.2	0.2	0.5	-0.7	0.4	0.5	-0.5	0.3	0.5
Locomotion velocity, session 7	0.0	0.0	0.2	0.2	0.0	-0.4	0.1	-0.1	0.2
Locomotion distance, session 7	0.9	1.1	1.6	1.0	-1.0	-1.3	1.1	-1.1	-0.6
Stereotopy head waving bouts, day 7	0.0	0.0	0.1	-0.2	0.3	0.3	-0.1	-0.2	-0.1
Stereotopy head waving duration, day 7	0.3	0.4	0.5	-0.7	0.7	0.7	-0.7	0.4	-0.0
Locomotion velocity, session 8	0.3	0.4	0.7	-0.6	0.6	0.4	-0.8	0.8	0.6
Locomotion distance, session 8	0.8	1.1	1.8	-1.4	1.3	0.9	-0.8	0.8	1.1
Degree of sensitization distance	1.2	1.2	1.6	1.1	-1.2	-1.3	1.0	-1.1	-0.9
Degree of sensitization stereotypy	0.3	0.3	0.8	0.5	-0.3	-0.4	0.5	-0.9	-0.7
Conditioned locomotion	2.3	2.7	4.2	-1.6	1.8	1.8	-2.1	1.7	-0.2
Cocaine response after cond. corrected	0.1	0.2	0.3	-0.3	0.3	0.4	-0.5	0.3	-0.6
Cocaine response after cond. not corrected	0.6	0.6	1.0	-0.7	0.7	1.0	-1.0	0.9	-0.1
Cocaine response before conditioning	1.6	1.9	2.7	-1.3	1.2	1.6	-1.5	1.6	0.9
Saline control response	1.5	2.0	2.6	-1.6	1.6	1.4	-1.5	1.3	1.0
Bone: connectivity density	1.8	2.8	3.7	-1.8	1.8	1.8	-1.9	1.6	1.0
Bone: cortical apparent density	0.0	0.1	0.1	-0.3	0.2	0.1	-0.1	0.1	0.4
Bone: cortical area	0.0	0.0	0.1	0.1	0.0	0.1	0.1	-0.1	-0.3
Bone: cortical porosity	2.5	2.7	4.1	-1.5	1.7	1.7	-2.0	2.0	0.4
Bone: cortical porosity	1.8	2.0	3.2	-1.3	1.4	1.4	-1.8	1.8	0.4
Bone: cortical thickness	0.1	0.1	0.3	0.4	-0.3	-0.3	0.6	-0.4	-0.1
Bone: cortical thickness	0.8	0.9	1.5	-1.0	0.9	0.9	-0.8	1.2	0.7
Bone: cortical tissue density	0.0	0.0	0.1	-0.2	0.1	0.1	-0.0	0.1	0.3
Condit. Reinf. active minus inactive responses	2.4	2.7	3.4	1.9	-1.7	-1.6	1.7	-1.5	-1.4
Condit. Reinf. active-inactive response ratio	2.4	2.6	3.3	1.8	-1.8	-1.7	1.8	-1.6	-0.9
Condit. Reinf. active responses	0.2	0.3	0.6	0.6	-0.5	-0.4	0.4	-0.3	-0.8
Condit. Reinf. inactive responses	1.6	1.9	2.5	-1.4	1.6	1.5	-1.5	1.5	0.6
Incentive salience index mean	0.6	0.8	2.0	1.0	-0.8	-0.7	0.6	-0.5	-1.4
Condit. Reinf. lever presses	0.6	0.8	1.2	-0.6	0.9	1.0	-1.1	1.1	-0.7
Condit. Reinf. active minus inactive responses	1.0	1.3	1.8	-1.1	1.0	1.3	-1.3	1.3	-0.4
Condit. Reinf. active-inactive response ratio	0.6	0.6	0.9	-0.5	0.6	0.9	-0.9	0.9	-0.8
Condit. Reinf. active responses	0.7	1.0	1.5	-1.0	0.9	1.2	-1.1	1.1	-0.6
Condit. Reinf. inactive responses	0.3	0.3	0.5	-0.6	0.6	0.7	-0.5	0.5	-0.5
Condit. Reinf. lever presses	0.8	1.1	1.4	-1.1	1.0	1.1	-1.2	1.2	-0.0
Condit. Reinf. lever reinforcers received	0.6	0.9	1.2	-0.9	0.8	1.1	-1.0	1.1	-0.5
Conditioned reinforcement - actives	3.6	3.6	4.4	-2.0	1.8	2.0	-1.9	2.1	1.5
Conditioned reinforcement - inactives	5.9	6.7	9.1	-3.0	2.7	2.7	-2.8	2.6	1.4
Conditioned locomotion	4.2	5.0	6.8	-2.0	2.4	1.8	-2.2	2.6	2.4
Patch foraging indifference point 0 sec	0.3	0.4	1.2	0.4	-0.2	-0.3	0.8	-0.6	1.1
Patch foraging indifference point AUC	0.1	0.1	0.3	-0.2	0.3	0.0	-0.2	-0.1	-0.5
Delay disc. indifference point, 0s delay	0.5	0.6	1.6	0.3	-0.5	-0.6	0.9	-1.3	0.6
Delay disc. indifference point, 16s delay	0.0	0.0	0.0	-0.1	-0.2	-0.1	0.2	-0.1	0.2
Delay disc. indifference point, 2s delay	0.2	0.3	0.6	0.2	-0.2	-0.7	0.4	-0.6	0.7
Delay disc. indifference point, 24s delay	2.9	2.8	4.7	-1.6	2.2	1.5	-1.9	2.0	0.5
Delay disc. indifference point, 4s delay	0.3	0.3	0.5	0.1	-0.5	-0.5	0.6	-0.7	0.6
Delay disc. indifference point, 8s delay	0.0	0.0	0.1	-0.0	0.2	-0.1	-0.0	-0.2	-0.0
Indifference point function ln k	1.7	2.3	2.6	-1.6	1.5	1.6	-1.6	1.5	1.2
Indifference point function log k	1.7	2.3	2.6	-1.6	1.5	1.6	-1.6	1.5	1.2
Patch foraging total patch changes 0 sec	0.3	0.4	1.6	0.2	-0.1	-0.2	0.7	-0.5	1.3
Patch foraging total patch changes 12 sec	1.0	1.3	1.8	1.4	-0.9	-1.1	1.1	-1.3	-1.0
Patch foraging total patch changes 18 sec	0.4	0.5	0.8	0.6	-0.6	-0.6	0.9	-0.7	0.8
Patch foraging total patch changes 24 sec	0.4	0.5	1.0	0.7	-0.6	-0.5	1.0	-1.0	-0.1
Patch foraging total patch changes 6 sec	0.8	1.3	2.2	1.1	-0.8	-1.1	1.5	-1.5	0.1
Patch foraging time to switch 0 sec	0.9	1.4	1.9	1.3	-1.4	-1.3	1.1	-1.1	-0.7
Patch foraging water rate 0 sec	3.0	4.8	6.9	-2.3	2.6	2.3	-1.9	2.0	1.8
Patch foraging water rate 12 sec	0.0	0.0	0.0	-0.1	0.2	0.1	0.2	-0.2	0.1
Patch foraging water rate 18 sec	3.0	4.1	5.2	-2.3	2.2	2.3	-1.6	1.8	1.8
Patch foraging water rate 24 sec	0.0	0.0	0.1	0.3	-0.1	-0.2	0.3	-0.1	0.2
Patch foraging water rate 6 sec	0.9	1.4	2.4	-1.4	1.2	1.5	-0.8	1.1	0.9
Seeking ratio, delayed vs. immediate footshock	0.4	0.4	0.8	0.7	-0.9	-0.6	0.2	-0.4	-0.9
Distance traveled before self-admin	0.1	0.1	0.1	-0.2	0.3	0.3	-0.3	0.2	-0.1
Distance traveled after self-admin	0.0	0.0	0.1	0.0	-0.1	0.0	0.3	-0.2	0.4
Extensor digitorum longus weight	1.9	7.7	10.0	-2.9	2.9	3.0	-3.1	3.2	0.9
Bone: elastic displacement	2.0	2.2	3.0	-1.6	1.7	1.6	-1.5	1.5	0.8
Bone: elastic work	1.2	1.6	2.5	-1.3	1.5	1.1	-0.9	0.9	1.6
Bone: endosteal estimation	0.2	0.4	0.5	-0.7	0.7	0.7	-0.5	0.5	0.7
Bone: endosteal perimeter	0.0	0.0	0.0	0.1	-0.2	0.1	-0.0	-0.0	-0.1
Epididymis fat weight	19.9	46.3	59.3	7.7	-7.2	-7.5	6.7	-6.9	-4.2
Delta time in closed arm before/after self-admin	0.4	0.4	0.6	0.5	-0.6	-0.6	0.6	-0.8	-0.6
Delta time in open arm before/after self-admin	0.2	0.2	1.0	0.1	0.1	0.0	-0.3	0.3	-1.0
Diff in mean of infusions in LGA sessions	0.3	0.4	1.8	0.4	-0.4	-0.2	-0.2	-0.2	-1.3
Delay discount exponential model param	0.0	0.0	0.1	0.1	-0.1	0.3	-0.0	0.2	-0.2
Extinction: sum of active levers before priming	0.2	0.2	0.6	0.1	0.2	0.2	-0.5	0.3	-0.8
Active lever presses in extinction session 6	1.7	1.7	3.2	-0.5	1.3	1.0	-1.6	1.2	-1.8
Bone: final force	0.1	0.1	0.2	0.3	-0.3	-0.3	0.2	-0.4	-0.1
Bone: final moment	0.0	0.0	0.1	0.2	-0.1	-0.2	0.1	-0.4	0.0
Food consumed during 24 hour testing period	0.1	0.1	0.2	-0.4	0.4	0.5	-0.0	0.1	0.2
Glucose	0.3	0.4	0.8	0.4	-0.6	-0.8	0.6	-0.9	-0.5
Heart weight	4.8	6.8	9.6	2.6	-3.1	-2.6	2.9	-2.9	-0.9
Delay discount hyperbolic model param	0.0	0.1	0.1	0.0	-0.0	0.3	-0.1	0.3	-0.3
Intermittent access intake day 1-15 change	3.8	3.8	6.0	-2.2	1.7	1.9	-1.4	1.8	2.4
Intermittent access intake escalation	2.9	2.8	5.2	-1.9	1.4	1.6	-1.1	1.6	2.3
Intermittent access intake escalation 2	0.9	0.9	4.2	-0.8	0.2	0.4	0.2	0.4	2.0
Intermitt. access day 1 inactive lever presses	0.3	0.4	0.7	-0.4	0.6	0.6	-0.7	0.3	-0.8
Intermitt. access day 15 inactive lever presses	1.2	1.3	2.0	-1.2	1.0	1.4	-1.4	1.0	-0.7
Intermitt. access escalation Index	3.8	3.4	5.5	1.7	-2.4	-1.9	2.0	-2.0	-0.1
Intermittent access day 1 total infusions	1.5	1.7	3.3	-1.5	1.2	1.4	-1.8	1.2	-0.3
Intermittent access day 15 total infusions	3.1	3.5	4.8	-2.2	1.6	2.1	-2.0	2.0	1.0
Intermittent access terminal intake (last 3 days)	2.5	2.8	3.6	-1.9	1.6	1.7	-1.8	1.8	1.1
Intermittent access total infusions	2.5	2.8	4.8	-1.6	1.8	1.6	-2.2	1.9	0.0
Intermittent access day 1 locomotion	2.1	2.2	3.0	-1.7	1.4	1.4	-1.7	1.4	1.1
Intermittent access day 15 total locomotion	0.6	0.6	1.0	-0.9	0.8	0.7	-0.6	0.6	1.0
Intermittent access total locomotion	1.0	1.2	1.4	-1.1	1.2	0.9	-1.1	1.1	1.1
Intermittent access standard deviation	0.6	0.7	0.8	-0.9	0.8	0.9	-0.8	0.9	0.5
Left kidney weight	0.2	0.5	1.2	-0.5	0.4	0.4	-1.1	0.7	-0.7
Right kidney weight	0.5	1.5	2.1	1.4	-1.4	-1.2	0.7	-0.8	-1.5
Cocaine induced anxiety	0.6	0.6	2.6	-0.8	0.5	0.5	-0.1	0.3	1.6
Post-drug Anxiety	0.4	0.4	1.1	0.2	-0.5	-0.4	1.0	-0.9	0.5
Baseline Anxiety	0.9	0.9	1.2	0.9	-1.1	-0.8	1.0	-1.1	-1.0
Tail length	0.3	1.0	1.7	-0.9	1.2	1.3	-0.9	1.1	0.1
Length with tail	0.0	0.2	0.4	0.6	-0.4	-0.1	0.3	0.2	-0.6
Length without tail	0.1	0.3	0.6	0.7	-0.7	-0.6	0.2	0.1	-0.0
Times rat made contact with spout	1.0	1.1	1.8	-1.0	0.9	1.0	-0.9	1.3	1.1
Lifetime Intake	2.9	3.3	5.6	-1.8	1.9	1.8	-2.4	2.0	0.0
Liver weight, left	1.1	1.8	3.5	1.3	-1.2	-1.2	1.1	-1.2	-1.9
Liver weight, right	4.2	6.9	8.2	2.8	-2.6	-2.8	2.8	-2.9	-1.7
Locomotor activity	1.7	2.6	6.4	1.8	-1.4	-1.4	1.0	-1.1	-2.5
Locomotor testing distance	1.4	2.3	6.9	1.5	-1.2	-1.0	0.9	-1.2	-2.6
Locomotor testing rearing	0.5	0.8	3.9	0.2	0.3	0.3	-0.7	0.6	-2.0
Locomotion in novel chamber	1.0	1.2	2.5	1.3	-1.0	-1.1	0.6	-0.7	-1.6
Locomotion in novel chamber post-restriction	1.4	1.7	2.8	1.1	-1.4	-1.3	1.7	-1.4	0.7
Fecal boli incidents, locomotor time 1	3.6	3.9	4.6	-2.1	2.1	2.0	-2.0	2.0	1.5
Change in fecal boli incidents, locomotor task	3.9	3.7	5.0	2.2	-2.2	-2.0	2.2	-1.9	-0.6
Time >=10cm from walls, locomotor time 1	0.4	0.4	0.8	-0.4	0.7	0.7	-0.6	0.9	0.2
Bouts of movement, locomotor time 1	0.5	0.6	1.4	-0.8	1.2	0.9	-0.3	0.3	0.7
Total resting periods, locomotor time 1	0.7	0.8	1.6	-0.9	1.3	1.1	-0.4	0.4	0.8
Rest time, locomotor task time 1	0.3	0.4	1.1	-0.6	1.0	0.5	-0.2	0.1	0.7
Distance moved, locomotor task time 1	0.8	0.8	1.5	1.1	-1.2	-1.0	0.5	-0.4	-1.0
Vertical activity count, locomotor time 1	0.3	0.3	0.7	0.5	-0.9	-0.6	0.5	-0.2	0.3
Time >=10cm from walls, locomotor time 2	0.9	0.9	1.3	-1.0	0.8	0.8	-1.1	1.1	0.8
Bouts of movement, locomotor time 2	0.2	0.2	0.5	-0.1	0.0	-0.0	0.6	-0.5	0.7
Total resting periods, locomotor time 2	0.2	0.2	0.6	-0.1	-0.0	-0.0	0.7	-0.6	0.8
Rest time, locomotor task time 2	0.1	0.1	0.3	-0.2	0.6	0.1	-0.0	-0.0	0.4
Distance moved, locomotor task time 2	0.0	0.0	0.1	0.1	-0.2	-0.2	-0.1	0.1	0.0
Vertical activity count, locomotor time 2	0.0	0.0	0.1	-0.1	0.0	0.1	-0.4	0.1	0.2
Light reinforcement 1	0.6	1.0	2.1	-1.1	1.0	1.5	-1.0	0.8	-0.6
Light reinforcement 2	1.8	2.4	3.4	-1.9	1.3	1.8	-1.3	1.3	1.7
Bone: marrow area	0.2	0.4	0.5	-0.7	0.7	0.7	-0.5	0.6	0.7
Bone: maximum diameter	0.1	0.1	0.2	-0.4	0.3	0.5	-0.1	0.2	0.4
Bone: maximum force	0.0	0.0	0.1	0.2	-0.2	-0.1	0.1	-0.3	-0.0
Bone: maximum moment	0.0	0.0	0.0	0.1	-0.0	0.0	0.1	-0.2	0.2
Mean time between licks in bursts	1.3	1.8	2.9	1.2	-1.2	-1.4	1.4	-1.7	-0.9
Mean num. licks in bursts	2.6	3.1	4.6	-1.7	1.8	1.5	-1.4	1.7	2.1
Cd content in liver	0.1	0.1	0.5	0.1	-0.2	0.1	0.6	0.2	0.7
Co content in liver	3.1	3.6	5.3	-1.8	2.1	2.0	-2.3	2.1	0.2
Cu content in liver	0.8	0.9	3.5	1.0	-0.9	-0.6	-0.0	-0.0	-1.9
Fe content in liver	0.3	0.4	0.5	-0.7	0.7	0.6	-0.5	0.7	0.5
K content in liver	2.2	2.1	2.7	1.6	-1.6	-1.5	1.5	-1.4	-1.1
Mg content in liver	1.6	1.6	2.0	1.3	-1.4	-1.4	1.4	-1.4	-0.4
Mn content in liver	0.2	0.2	0.4	0.3	-0.2	-0.6	0.5	-0.5	0.6
Na content in liver	2.6	2.8	4.1	-2.0	1.9	1.7	-1.7	1.4	1.1
Rb content in liver	0.5	0.6	0.8	0.9	-0.9	-0.5	0.8	-0.6	-0.9
Se content in liver	0.8	1.0	1.5	1.1	-1.2	-1.2	1.0	-1.0	-0.2
Sr content in liver	0.1	0.1	0.2	0.1	-0.1	-0.4	0.3	-0.3	0.5
Zn content in liver	3.8	4.2	7.8	2.4	-2.2	-1.7	1.3	-1.5	-2.8
Bone: minimum diameter	0.7	1.3	1.7	1.3	-1.3	-1.0	1.1	-1.2	-1.0
Time in familiar zone, hab. session 1	1.5	1.4	1.7	1.3	-1.3	-1.3	1.0	-1.1	-1.1
Time in novel zone, hab. session 1	0.3	0.3	0.5	0.6	-0.7	-0.7	0.6	-0.5	0.1
Total zone transitions, hab. session 1	0.6	0.8	1.4	-1.0	1.2	1.0	-0.7	0.9	0.3
Total locomotion distance, hab. session 1	1.2	1.7	2.6	-1.4	1.4	1.6	-1.3	1.5	0.4
Locomotion velocity, hab. session 1	2.2	3.2	4.5	-2.0	2.0	2.1	-1.7	1.8	0.7
Time in familiar zone, hab. session 2	0.3	0.3	0.5	0.4	-0.4	-0.6	0.6	-0.7	0.2
Time in novel zone, hab. session 2	0.3	0.3	0.5	0.6	-0.7	-0.5	0.2	-0.2	-0.6
Total zone transitions, hab. session 2	0.1	0.2	0.6	-0.3	0.5	0.3	0.1	0.3	0.8
Total locomotion distance, hab. session 2	0.1	0.1	0.4	-0.2	0.2	0.4	0.2	0.3	0.7
Locomotion velocity, hab. session 2	0.1	0.2	0.4	-0.3	0.3	0.6	-0.0	0.4	0.5
Novel to familiar place preference ratio	0.1	0.1	0.4	-0.2	0.1	0.3	0.4	0.2	0.6
Novelty place preference	0.1	0.1	0.3	0.1	-0.1	0.1	0.6	-0.1	0.3
Time in novel zone, NPP test	0.1	0.1	0.4	0.3	-0.3	-0.1	0.6	-0.1	0.3
Total zone transitions, NPP test	0.8	1.1	1.6	-1.0	1.1	1.2	-1.3	1.2	-0.4
Total locomotion distance, NPP test	1.5	2.1	2.9	-1.4	1.5	1.7	-1.6	1.7	0.3
Locomotion velocity, NPP test	2.2	3.2	4.7	-1.8	1.9	2.2	-1.9	1.9	0.3
Intraocular pressure	3.3	4.7	6.2	2.4	-2.3	-2.5	2.4	-2.2	-0.2
Delta distance traveled before/after self-admin	1.1	1.1	1.7	1.0	-1.1	-1.1	1.2	-1.3	-0.5
Delta ambulatory time before/after self-admin	0.2	0.2	0.3	0.2	-0.2	-0.4	0.5	-0.5	0.6
Parametrial fat weight	12.6	24.5	28.8	5.4	-5.1	-5.1	4.7	-5.0	-4.5
Pavlov. Cond. lever latency	0.4	0.6	0.9	0.5	-0.8	-0.7	0.9	-0.6	0.8
Pavlov. Cond. magazine entry latency	0.1	0.1	0.6	0.3	-0.0	-0.1	0.0	-0.1	-0.8
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	-0.2	0.4	0.1	-0.2	-0.0	-0.1
Pavlov. Cond. index score	0.1	0.1	0.3	-0.0	0.4	0.2	-0.4	0.1	-0.5
Pavlov. Cond. latency score	0.1	0.1	0.2	-0.0	0.4	0.1	-0.3	0.1	-0.4
Pavlov. Cond. lever contacts	0.4	0.5	0.9	-0.5	0.9	0.6	-0.9	0.5	-0.6
Pavlov. Cond. magazine entry number	0.1	0.2	0.4	0.2	-0.6	-0.4	0.4	-0.3	0.3
Pavlov. Cond. intertrial magazine entries	0.7	0.9	1.5	-0.9	0.6	0.9	-1.2	1.2	0.7
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.7	-0.5	0.8	0.5	-0.8	0.5	-0.4
Pavlov. Cond. response bias	0.9	1.1	1.9	-1.0	1.4	1.1	-1.3	0.9	-0.3
Pavlov. Cond. lever latency	0.6	0.8	1.1	1.1	-1.1	-0.8	1.0	-0.8	-0.3
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	-0.1	-0.1	-0.2	0.1	-0.1	-0.1
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	-0.3	0.3	-0.1	-0.2	0.1	-0.2
Pavlov. Cond. index score	0.3	0.3	0.6	-0.8	0.7	0.4	-0.6	0.6	0.4
Pavlov. Cond. latency score	0.3	0.4	0.6	-0.8	0.7	0.4	-0.6	0.6	0.5
Pavlov. Cond. lever contacts	0.1	0.1	0.2	-0.5	0.5	0.2	-0.5	0.2	-0.3
Pavlov. Cond. magazine entry number	0.2	0.3	0.6	-0.5	0.6	0.7	-0.4	0.4	0.3
Pavlov. Cond. intertrial magazine entries	1.4	1.9	3.2	1.3	-1.5	-1.3	1.8	-1.2	0.9
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	-0.5	0.4	0.1	-0.3	0.3	0.4
Pavlov. Cond. response bias	0.2	0.3	0.5	-0.7	0.7	0.4	-0.7	0.4	-0.1
Time in closed arm before self-admin	0.1	0.2	0.5	-0.1	0.2	0.3	-0.1	0.6	0.7
Time in closed arm after self-admin	0.5	0.5	0.7	0.9	-0.8	-0.5	0.6	-0.3	-0.8
Time in open arm before self-admin	0.1	0.1	0.3	0.2	-0.1	-0.5	0.3	-0.6	-0.1
Time in open arm after self-admin	0.1	0.1	0.2	-0.5	0.4	0.3	-0.3	0.2	0.2
Bone: periosteal estimation	0.2	0.3	0.5	-0.6	0.7	0.7	-0.5	0.6	0.4
Bone: periosteal perimeter	0.0	0.0	0.0	0.0	-0.1	0.2	0.1	-0.2	-0.1
Bone: post-yield work	1.0	1.4	2.3	-1.1	1.1	1.2	-1.5	1.5	0.1
Progressive ratio test 1 active lever presses	1.8	1.9	3.2	-1.1	1.5	1.2	-1.8	1.5	-0.9
Progressive ratio test 1 breakpoint	1.3	1.4	2.4	-1.0	1.4	1.1	-1.5	1.2	-0.5
Progressive ratio test 1 inactive lever presses	2.9	3.2	5.4	-1.7	1.9	1.9	-2.3	1.9	-0.4
Progressive ratio test 2 active lever presses	1.9	2.0	2.6	-1.6	1.4	1.2	-1.6	1.6	1.0
Progressive ratio test 2 breakpoint	1.9	2.1	2.6	-1.6	1.5	1.2	-1.6	1.6	1.1
Progressive ratio test 2 inactive lever presses	3.2	3.6	5.1	-2.3	2.0	1.9	-2.0	1.8	1.4
Incentive Sensitization - Responses	1.5	1.5	2.4	-1.3	0.9	0.9	-1.1	1.3	1.5
Incentive Sensitization - Breakpoint	1.0	1.0	2.2	-1.1	0.6	0.7	-0.9	1.1	1.5
Sum of active levers in priming session hrs 5-6	0.1	0.0	0.2	-0.2	0.0	0.3	0.1	-0.0	0.4
Progressive ratio	0.1	0.1	0.2	0.2	-0.2	-0.0	-0.5	0.3	-0.5
Food seeking constrained by brief footshock	9.8	12.1	19.2	-3.2	3.4	3.6	-4.4	4.2	0.2
Seeking ratio, punishment vs. effort	1.5	1.9	2.4	-1.5	1.6	1.5	-1.3	1.4	0.8
Retroperitoneal fat weight	34.6	113.7	135.6	11.6	-11.6	-11.3	10.9	-11.1	-6.7
Reaction time number correct	0.4	0.6	0.7	-0.7	0.7	0.8	-0.7	0.8	0.8
Reaction time mean minus median	1.6	2.1	6.2	1.5	-1.6	-1.1	0.5	-0.6	-2.5
Reaction time mean minus median AUC	1.4	1.8	5.9	1.2	-1.5	-0.9	0.5	-0.7	-2.4
Reaction time num false alarms	1.6	2.2	2.9	1.7	-1.7	-1.2	1.4	-1.3	-1.6
Reaction time num false alarms AUC	1.4	2.0	2.5	1.6	-1.6	-1.2	1.4	-1.3	-1.5
Reaction time trials correct on left	0.4	0.6	0.7	-0.7	0.7	0.8	-0.7	0.8	0.8
Reaction time trials on left	0.3	0.5	0.6	-0.6	0.7	0.8	-0.6	0.8	0.6
Reaction time mean	0.4	0.6	1.3	0.6	-1.1	-0.7	0.5	-0.6	-0.8
Reaction time mean AUC	0.3	0.3	0.8	0.4	-0.9	-0.5	0.3	-0.4	-0.8
Median of all reaction times	0.1	0.1	0.3	-0.1	-0.6	-0.3	0.2	-0.3	0.2
Reaction time omissions	0.8	1.1	4.5	0.8	-0.8	-0.4	0.5	-0.6	-2.1
Reaction time false alarm rate	2.1	2.9	3.7	1.9	-1.9	-1.6	1.8	-1.7	-1.4
Reaction time premature initiation rate	0.1	0.2	0.9	-0.0	0.1	-0.1	0.3	-0.0	0.9
Reaction time premature initiations	0.3	0.4	1.7	-0.5	0.5	0.4	-0.1	0.3	1.3
Std. dev. reaction times	1.4	2.0	4.8	1.4	-1.6	-1.1	0.8	-0.8	-2.2
Reaction time trials completed	0.3	0.5	0.6	-0.6	0.7	0.8	-0.6	0.8	0.6
Reaction time trials AUC	0.3	0.4	0.5	-0.6	0.6	0.7	-0.7	0.7	0.5
Run reversals in cocaine runway, females	0.8	0.8	1.2	-0.9	1.1	0.8	-0.6	0.7	1.1
Run reversals in cocaine runway, males	1.4	1.4	2.0	-1.3	1.3	1.4	-1.2	1.2	0.3
Latency to leave start box in cocaine runway	0.0	0.0	0.1	-0.1	0.0	-0.1	-0.2	-0.0	0.1
Latency to leave start box in cocaine runway, F	0.2	0.2	0.4	0.4	-0.4	-0.4	0.1	-0.3	-0.6
Latency to leave start box in cocaine runway, M	1.0	0.9	1.4	-1.2	1.0	0.9	-1.2	0.9	0.5
Std. dev. time between licks in bursts	0.3	0.3	0.7	0.2	-0.3	-0.5	0.8	-0.9	0.2
Total sessions with >9 infusions	5.0	5.6	8.2	-2.3	2.7	2.4	-2.9	2.6	0.3
Short access day 1 total inactive lever presses	1.9	2.2	3.2	-1.8	1.6	1.6	-1.7	1.2	0.4
Short access day 10 total inactive lever presses	0.5	0.5	2.2	0.4	-0.4	-0.3	0.2	-0.7	-1.5
Short access day 1 total infusions	2.1	2.2	3.8	-1.4	1.7	1.4	-1.9	1.7	-0.2
Short access day 10 total infusions	3.2	3.5	5.8	-1.9	1.8	2.0	-2.4	2.0	-0.1
Short access total infusions	2.4	2.7	4.8	-1.6	1.8	1.6	-2.2	1.8	-0.3
Short access day 1 locomotion	3.2	3.4	5.5	-1.6	2.1	1.7	-2.3	2.3	0.3
Short access day 10 total locomotion	1.4	1.6	2.0	-1.3	1.2	1.4	-1.4	1.4	0.8
Short access total locomotion	2.5	2.6	3.0	-1.7	1.7	1.5	-1.7	1.6	1.3
One hour access (0.3 mA shock)	3.0	3.6	4.9	-2.1	1.7	1.7	-1.6	1.9	2.2
Compulsive drug intake	2.9	2.9	4.6	1.2	-1.9	-1.7	2.1	-2.1	0.5
One hour access (shock baseline)	4.8	5.6	8.8	-2.1	2.6	2.3	-2.7	3.0	1.0
Social response proportion	0.1	0.1	0.2	0.4	-0.2	-0.5	0.1	-0.0	0.4
Social responses	0.3	0.4	0.7	0.7	-0.4	-0.6	0.5	-0.6	-0.8
Social time	0.0	0.0	0.0	0.1	0.1	-0.2	-0.1	0.1	0.0
Soleus weight	3.4	9.9	12.4	-3.5	3.5	3.5	-3.1	3.1	2.0
Bone: stiffness	0.1	0.2	0.5	0.3	-0.4	-0.3	0.4	-0.7	-0.2
Tibialis anterior weight	1.1	3.9	5.3	-2.1	2.2	2.3	-1.9	2.2	0.9
Time to tail flick, vehicle, before self-admin	0.7	0.7	1.8	1.2	-0.6	-0.7	0.4	-0.5	-1.4
Time to tail flick, vehicle, after self-admin	6.7	7.2	9.8	3.1	-2.6	-3.0	2.7	-2.6	-1.9
Time to tail flick, test, before self-admin	1.7	1.7	2.5	-1.2	1.4	1.4	-1.3	1.6	0.7
Time to tail flick, test, after self-admin	0.9	0.9	1.2	-0.9	1.0	0.9	-1.1	1.0	0.6
Delta time to tail flick, vehicle, before/after SA	1.9	1.8	2.9	1.3	-1.3	-1.5	1.7	-1.6	-0.3
Delta time to tail flick, test, before/after SA	1.0	0.9	1.3	-1.1	0.8	0.7	-1.0	0.6	1.1
Tibia length	0.5	1.5	1.9	1.3	-1.3	-1.1	1.4	-1.2	-1.0
Ambulatory time before self-admin	0.1	0.1	0.2	-0.2	0.1	0.2	-0.3	0.2	-0.5
Ambulatory time after self-admin	0.0	0.0	0.1	-0.2	0.1	0.3	0.1	-0.0	0.1
Bone: tissue strength	0.6	0.5	1.3	0.6	-0.6	-0.8	0.7	-1.1	0.0
Total heroin consumption	2.3	2.7	3.6	-1.8	1.9	1.4	-1.3	1.5	1.9
Bone: trabecular number	3.3	5.1	6.3	-2.4	2.5	2.4	-2.5	2.3	1.2
Bone: trabecular spacing	0.5	0.7	1.1	0.8	-0.7	-0.9	1.0	-1.0	-0.4
Bone: trabecular thickness	0.2	0.2	0.5	-0.2	0.2	0.5	-0.7	0.7	-0.4
Bone: trabecular tissue density	0.0	0.0	0.1	0.0	-0.0	0.2	-0.2	0.4	-0.1
Water consumed over 24 hours	0.2	0.3	0.4	-0.6	0.6	0.5	-0.3	0.5	0.5
Number of responses in last shaping day	1.5	1.6	2.5	-1.2	1.5	1.3	-1.6	1.2	0.2