Hub : Genes

Sf3b6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IC mRNA stability Sf3b6 0.1 0.06 4.2e-04 0.03 0.06 0.02 0.04 2.4e-02 1.7e-03 5.7e-02 6.4e-03
2 pVTA mRNA stability Sf3b6 0.12 0.06 2.8e-14 0.16 0.18 0.17 0.17 3.4e-13 2.2e-14 8.4e-14 9.6e-14
3 BLA mRNA stability Sf3b6 0.09 0.05 3.9e-06 0.08 0.09 0.08 0.08 3.9e-05 3.0e-05 6.2e-05 6.8e-05
4 BLA gene expression Sf3b6 0.06 0.04 7.2e-04 0.06 0.04 0.05 0.06 5.0e-04 3.1e-03 7.7e-04 5.5e-04
5 NAcc mRNA stability Sf3b6 0.07 0.03 0.0e+00 0.12 0.13 0.12 0.12 2.6e-18 1.6e-18 3.3e-17 1.4e-17
6 NAcc gene expression Sf3b6 0.04 0.02 4.5e-07 0.05 0.05 0.05 0.05 3.8e-08 5.7e-08 7.5e-08 8.2e-08
7 pVTA gene expression Sf3b6 0.06 0.04 7.2e-06 0.07 0.07 0.07 0.07 2.9e-06 2.1e-06 4.4e-06 1.4e-06
8 Adipose gene expression Sf3b6 0.05 0.03 2.5e-06 0.04 0.03 0.03 0.03 6.3e-05 9.7e-05 5.0e-04 4.4e-04
9 PL gene expression Sf3b6 0.06 0.04 1.2e-09 0.1 0.09 0.09 0.09 5.7e-11 2.2e-10 6.3e-10 1.8e-10
10 PL mRNA stability Sf3b6 0.13 0.06 0.0e+00 0.21 0.21 0.21 0.22 1.4e-22 2.0e-22 9.8e-23 2.5e-23
11 Liver gene expression Sf3b6 0.03 0.02 1.7e-03 0.01 0.02 0.01 0.01 3.7e-02 3.1e-03 6.8e-03 2.6e-02
12 OFC mRNA stability Sf3b6 0.27 0.14 1.1e-05 0.21 0.17 0.17 0.17 9.4e-06 6.5e-05 9.3e-05 6.0e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density4.17.19.03.02.72.92.42.92.42.72.52.52.72.32.9
Area under the delay curve0.10.10.3-0.1-0.4-0.3-0.4-0.3-0.4-0.3-0.4-0.4-0.4-0.5-0.1
BMI with tail0.20.52.4-1.6-1.0-0.9-0.5-0.7-0.5-0.5-0.4-0.5-0.5-0.3-0.1
BMI without tail0.10.20.5-0.7-0.2-0.00.40.20.40.30.40.40.30.50.7
Body weight0.62.45.6-2.4-1.9-1.7-1.7-1.5-1.7-1.4-1.4-1.3-1.3-1.1-0.8
Weight adjusted by age0.00.10.2-0.20.10.2-0.30.1-0.10.20.20.20.20.30.5
Bone surface0.81.52.21.51.21.41.11.41.01.21.21.21.31.01.2
Bone volume1.62.94.52.11.81.91.41.91.31.71.61.61.71.41.8
Breakpoint value in progressive ratio session0.60.81.51.20.81.00.71.00.80.80.80.80.80.41.0
Number of licking bursts0.71.12.2-1.5-1.2-1.2-0.9-1.1-1.0-1.0-1.0-1.0-1.0-0.8-0.7
Context. condit. distance diff. score2.32.83.41.61.61.71.71.71.61.71.61.61.61.61.9
Locomotion velocity, session 10.10.10.2-0.3-0.3-0.30.2-0.20.1-0.2-0.2-0.1-0.3-0.3-0.4
Locomotion distance, session 10.10.10.30.50.30.30.60.30.50.30.40.30.20.1-0.1
Locomotion velocity, session 20.10.10.2-0.4-0.3-0.30.3-0.30.0-0.3-0.3-0.3-0.4-0.3-0.2
Locomotion distance, session 20.20.20.4-0.3-0.5-0.4-0.4-0.4-0.4-0.5-0.5-0.5-0.6-0.6-0.6
Locomotion velocity, session 30.30.30.60.30.50.50.80.50.60.60.50.50.40.60.7
Locomotion distance, session 30.40.50.80.50.60.70.70.70.60.70.70.70.60.70.9
Stereotopy head waving bouts, day 32.53.04.02.01.81.82.01.71.91.71.71.71.71.41.1
Stereotopy head waving duration, day 30.30.40.50.60.70.60.70.60.70.60.60.70.60.60.2
Locomotion velocity, session 70.10.10.20.30.20.30.20.30.30.30.40.40.30.20.2
Locomotion distance, session 70.00.00.1-0.10.00.10.30.10.40.20.20.10.10.20.3
Stereotopy head waving bouts, day 70.10.10.2-0.4-0.4-0.4-0.3-0.4-0.4-0.3-0.4-0.4-0.3-0.4-0.3
Stereotopy head waving duration, day 70.00.00.0-0.2-0.1-0.1-0.1-0.2-0.2-0.1-0.2-0.2-0.1-0.00.0
Locomotion velocity, session 81.72.13.51.51.41.41.91.41.71.41.31.31.21.21.3
Locomotion distance, session 81.72.53.11.81.61.71.71.71.71.61.51.41.41.31.7
Degree of sensitization distance0.30.30.7-0.8-0.7-0.7-0.4-0.6-0.3-0.5-0.6-0.6-0.5-0.5-0.6
Degree of sensitization stereotypy1.71.92.3-1.5-1.4-1.4-1.4-1.4-1.4-1.4-1.4-1.4-1.3-1.3-1.1
Conditioned locomotion3.84.45.12.12.22.22.02.12.02.12.32.32.12.02.0
Cocaine response after cond. corrected0.60.71.3-0.6-0.8-0.7-1.1-0.7-1.1-0.8-0.8-0.8-0.8-0.9-0.3
Cocaine response after cond. not corrected0.70.81.2-0.5-0.8-0.8-1.1-0.8-1.1-0.9-1.0-1.0-0.9-1.0-0.5
Cocaine response before conditioning0.20.20.60.70.70.50.80.40.70.40.30.30.30.40.1
Saline control response0.20.30.80.90.70.60.40.60.40.50.40.40.50.40.3
Bone: connectivity density2.33.64.62.11.82.01.82.11.81.81.81.81.91.62.1
Bone: cortical apparent density0.40.51.5-0.1-0.8-0.6-0.6-0.6-0.7-0.7-0.7-0.7-0.8-1.2-0.6
Bone: cortical area0.30.50.9-0.6-0.5-0.6-0.9-0.6-1.0-0.5-0.7-0.7-0.6-0.4-1.0
Bone: cortical porosity0.00.00.30.50.40.30.10.20.10.10.00.00.00.10.0
Bone: cortical porosity0.50.61.11.10.90.80.70.80.70.70.70.70.60.70.6
Bone: cortical thickness2.13.54.6-1.6-1.7-1.8-2.1-1.8-2.1-1.8-2.0-2.0-1.8-1.8-2.0
Bone: cortical thickness0.10.10.10.2-0.1-0.1-0.2-0.1-0.3-0.2-0.3-0.3-0.2-0.4-0.4
Bone: cortical tissue density0.30.51.4-0.1-0.7-0.6-0.6-0.5-0.6-0.7-0.7-0.7-0.7-1.2-0.6
Condit. Reinf. active minus inactive responses3.33.75.1-2.1-2.0-2.0-2.3-1.9-2.2-1.9-1.8-1.8-1.8-1.7-1.5
Condit. Reinf. active-inactive response ratio1.61.72.8-1.4-1.4-1.3-1.7-1.2-1.6-1.3-1.1-1.1-1.1-1.1-0.9
Condit. Reinf. active responses0.60.71.2-0.9-0.8-0.8-1.1-0.8-1.1-0.8-0.8-0.8-0.8-0.7-0.5
Condit. Reinf. inactive responses0.81.01.51.11.01.01.01.01.00.90.90.90.80.91.2
Incentive salience index mean1.31.62.5-1.4-1.3-1.3-1.6-1.2-1.5-1.2-1.1-1.1-1.2-1.0-1.0
Condit. Reinf. lever presses0.00.10.2-0.1-0.1-0.2-0.5-0.2-0.4-0.2-0.2-0.2-0.3-0.1-0.2
Condit. Reinf. active minus inactive responses0.00.00.10.40.20.2-0.10.20.00.1-0.2-0.20.10.00.4
Condit. Reinf. active-inactive response ratio0.10.10.3-0.3-0.2-0.3-0.6-0.3-0.6-0.3-0.5-0.5-0.3-0.10.2
Condit. Reinf. active responses0.40.50.9-0.4-0.6-0.6-0.8-0.6-0.7-0.7-0.9-0.9-0.7-0.8-0.5
Condit. Reinf. inactive responses0.10.20.4-0.3-0.4-0.4-0.2-0.4-0.2-0.4-0.4-0.4-0.4-0.6-0.7
Condit. Reinf. lever presses0.40.51.1-0.3-0.7-0.7-0.2-0.8-0.2-0.8-0.8-0.8-1.0-1.0-0.8
Condit. Reinf. lever reinforcers received0.60.81.2-0.5-0.8-0.8-0.9-0.8-0.9-0.9-1.1-1.1-0.9-1.0-0.7
Conditioned reinforcement - actives0.30.42.01.40.80.80.30.70.20.50.40.40.50.20.7
Conditioned reinforcement - inactives0.40.62.21.51.00.90.70.80.60.60.60.60.70.50.6
Conditioned locomotion0.10.11.11.00.30.3-0.30.2-0.3-0.00.10.10.1-0.4-0.3
Patch foraging indifference point 0 sec0.40.71.00.70.80.80.80.80.80.90.90.91.00.90.6
Patch foraging indifference point AUC1.01.42.40.51.11.01.21.01.31.21.21.21.21.61.3
Delay disc. indifference point, 0s delay1.71.82.5-1.1-1.3-1.3-1.4-1.3-1.5-1.3-1.6-1.6-1.6-1.4-0.9
Delay disc. indifference point, 16s delay0.00.00.00.1-0.10.0-0.10.1-0.10.0-0.1-0.0-0.0-0.10.1
Delay disc. indifference point, 2s delay0.91.11.5-0.5-1.0-1.0-1.1-0.9-1.1-1.0-1.2-1.2-1.2-1.2-0.6
Delay disc. indifference point, 24s delay1.41.62.91.71.21.41.01.41.01.31.21.31.30.71.2
Delay disc. indifference point, 4s delay0.10.10.2-0.2-0.2-0.3-0.4-0.3-0.3-0.3-0.4-0.4-0.4-0.20.1
Delay disc. indifference point, 8s delay0.00.00.10.30.00.20.20.20.20.10.20.20.1-0.20.3
Indifference point function ln k0.00.10.40.60.10.1-0.00.1-0.3-0.1-0.2-0.2-0.2-0.5-0.3
Indifference point function log k0.00.10.40.60.10.1-0.00.1-0.3-0.1-0.2-0.2-0.2-0.5-0.3
Patch foraging total patch changes 0 sec0.30.60.90.60.80.80.80.80.80.90.90.90.90.90.6
Patch foraging total patch changes 12 sec0.10.10.4-0.70.0-0.1-0.0-0.0-0.10.20.20.10.20.60.4
Patch foraging total patch changes 18 sec1.32.03.00.81.31.31.71.31.71.51.51.41.41.61.5
Patch foraging total patch changes 24 sec0.00.10.3-0.6-0.2-0.2-0.4-0.2-0.2-0.00.20.10.20.30.1
Patch foraging total patch changes 6 sec0.10.20.6-0.40.20.10.20.20.20.40.40.40.40.80.5
Patch foraging time to switch 0 sec0.10.20.4-0.4-0.6-0.4-0.5-0.3-0.6-0.4-0.5-0.5-0.5-0.6-0.0
Patch foraging water rate 0 sec0.71.52.81.71.51.31.21.21.11.21.21.21.21.10.6
Patch foraging water rate 12 sec0.71.52.4-1.0-1.2-1.2-1.6-1.2-1.4-1.3-1.2-1.2-1.1-1.2-1.2
Patch foraging water rate 18 sec0.20.20.60.2-0.1-0.3-0.8-0.4-0.6-0.5-0.5-0.5-0.4-0.5-0.7
Patch foraging water rate 24 sec0.00.00.00.10.10.10.10.1-0.00.1-0.00.10.20.10.1
Patch foraging water rate 6 sec0.10.20.50.0-0.2-0.3-0.7-0.4-0.6-0.5-0.5-0.4-0.4-0.5-0.6
Seeking ratio, delayed vs. immediate footshock0.30.40.6-0.8-0.5-0.7-0.4-0.7-0.5-0.5-0.6-0.7-0.7-0.3-0.7
Distance traveled before self-admin0.00.00.10.10.10.00.20.10.20.20.20.20.10.0-0.1
Distance traveled after self-admin0.10.10.2-0.00.20.10.50.10.40.30.30.30.20.2-0.4
Extensor digitorum longus weight0.41.73.61.91.31.41.21.41.31.11.11.11.20.71.4
Bone: elastic displacement0.30.41.11.00.70.70.40.70.50.50.60.60.50.30.6
Bone: elastic work0.10.20.80.90.50.50.20.50.30.30.30.30.30.00.2
Bone: endosteal estimation1.12.42.81.41.61.61.71.61.51.61.51.51.51.61.6
Bone: endosteal perimeter0.51.11.50.71.01.01.21.01.01.21.11.11.11.20.7
Epididymis fat weight3.511.829.8-5.5-3.8-3.8-3.4-3.6-3.4-2.9-2.9-2.9-2.8-2.0-3.1
Delta time in closed arm before/after self-admin0.50.50.80.50.70.70.60.60.50.70.70.70.70.70.9
Delta time in open arm before/after self-admin0.10.10.3-0.6-0.4-0.40.1-0.3-0.0-0.2-0.1-0.1-0.1-0.2-0.3
Diff in mean of infusions in LGA sessions0.00.00.1-0.2-0.10.0-0.00.00.10.10.10.10.10.00.1
Delay discount exponential model param0.00.00.1-0.30.0-0.10.1-0.10.0-0.1-0.0-0.00.00.2-0.3
Extinction: sum of active levers before priming1.01.11.70.80.91.01.11.01.11.11.01.01.10.91.3
Active lever presses in extinction session 60.60.60.70.50.70.80.70.70.70.80.80.80.80.80.8
Bone: final force0.30.50.6-0.8-0.7-0.7-0.6-0.7-0.6-0.7-0.8-0.8-0.7-0.5-0.8
Bone: final moment0.20.30.4-0.6-0.5-0.5-0.4-0.5-0.5-0.5-0.6-0.6-0.5-0.4-0.6
Food consumed during 24 hour testing period0.00.10.2-0.3-0.1-0.30.2-0.40.2-0.2-0.1-0.1-0.3-0.1-0.4
Glucose0.00.00.1-0.3-0.2-0.1-0.2-0.0-0.1-0.00.10.10.10.0-0.0
Heart weight0.20.30.7-0.8-0.5-0.6-0.4-0.6-0.5-0.4-0.4-0.5-0.5-0.3-0.3
Delay discount hyperbolic model param0.00.00.1-0.10.20.10.20.10.20.10.20.10.20.4-0.1
Intermittent access intake day 1-15 change0.20.42.11.50.70.70.40.80.50.50.40.40.40.10.5
Intermittent access intake escalation0.10.31.51.20.50.50.20.60.30.30.30.30.3-0.00.3
Intermittent access intake escalation 20.40.51.71.30.70.70.50.80.70.60.50.50.50.20.5
Intermitt. access day 1 inactive lever presses0.00.00.00.10.20.1-0.10.0-0.10.0-0.0-0.00.00.20.1
Intermitt. access day 15 inactive lever presses0.40.81.20.71.00.81.00.71.00.90.90.90.91.10.2
Intermitt. access escalation Index0.10.10.5-0.7-0.4-0.40.1-0.30.2-0.10.10.10.1-0.0-0.3
Intermittent access day 1 total infusions0.00.00.10.1-0.10.0-0.3-0.1-0.3-0.2-0.2-0.2-0.2-0.3-0.0
Intermittent access day 15 total infusions0.10.10.50.70.00.1-0.50.1-0.3-0.2-0.2-0.2-0.2-0.5-0.1
Intermittent access terminal intake (last 3 days)0.40.61.20.3-0.4-0.4-0.9-0.5-0.8-0.8-0.8-0.8-0.8-1.1-0.9
Intermittent access total infusions0.20.30.60.4-0.3-0.1-0.8-0.2-0.7-0.5-0.5-0.5-0.5-0.8-0.2
Intermittent access day 1 locomotion1.11.42.2-0.4-1.0-0.9-1.4-1.1-1.4-1.2-1.2-1.2-1.2-1.5-1.2
Intermittent access day 15 total locomotion0.81.42.0-0.6-1.1-1.1-1.4-1.1-1.3-1.2-1.2-1.2-1.2-1.4-1.2
Intermittent access total locomotion1.51.83.4-0.4-1.1-1.0-1.8-1.1-1.8-1.4-1.4-1.4-1.4-1.7-1.1
Intermittent access standard deviation0.10.30.90.90.50.50.40.60.50.30.20.20.20.21.0
Left kidney weight0.00.00.0-0.2-0.1-0.0-0.10.00.0-0.00.00.00.10.10.2
Right kidney weight0.10.31.0-1.0-0.6-0.6-0.7-0.5-0.7-0.4-0.5-0.5-0.4-0.1-0.2
Cocaine induced anxiety1.42.02.51.61.31.51.51.61.41.51.51.51.51.11.2
Post-drug Anxiety0.40.40.70.10.50.50.80.50.80.70.70.70.70.80.3
Baseline Anxiety1.51.73.7-1.9-1.3-1.5-1.1-1.5-1.0-1.2-1.2-1.2-1.2-0.7-1.7
Tail length0.00.00.10.1-0.1-0.1-0.1-0.0-0.1-0.2-0.2-0.2-0.2-0.30.1
Length with tail0.31.22.1-1.1-1.1-1.1-1.4-1.0-1.4-1.1-1.1-1.0-0.9-1.0-0.9
Length without tail0.30.91.7-1.1-0.9-0.9-1.3-1.0-1.3-0.9-0.9-0.9-0.8-0.7-0.7
Times rat made contact with spout1.92.22.41.51.51.51.41.51.41.41.61.61.51.51.5
Lifetime Intake0.30.40.90.3-0.4-0.3-0.9-0.4-0.9-0.7-0.6-0.6-0.6-0.9-0.3
Liver weight, left5.08.39.0-3.0-3.0-3.0-2.8-3.0-2.8-2.9-2.9-2.8-2.9-2.7-2.7
Liver weight, right1.52.64.0-2.0-2.0-1.7-1.7-1.6-1.7-1.5-1.4-1.4-1.5-1.6-1.1
Locomotor activity0.91.43.3-1.8-1.4-1.3-1.2-1.3-1.1-1.1-0.9-0.9-1.0-0.8-0.8
Locomotor testing distance0.10.21.2-1.1-0.6-0.6-0.3-0.5-0.4-0.4-0.2-0.3-0.3-0.1-0.2
Locomotor testing rearing0.10.10.2-0.5-0.4-0.4-0.3-0.4-0.2-0.4-0.4-0.4-0.4-0.2-0.1
Locomotion in novel chamber2.63.44.0-1.9-2.0-1.8-1.7-1.8-1.8-1.8-1.9-1.9-1.9-1.9-1.5
Locomotion in novel chamber post-restriction0.91.41.8-1.2-1.1-1.1-1.0-1.2-1.2-1.1-1.3-1.3-1.2-1.0-1.3
Fecal boli incidents, locomotor time 10.60.92.31.51.01.00.61.10.70.91.00.90.90.51.0
Change in fecal boli incidents, locomotor task0.40.40.9-1.0-0.6-0.7-0.6-0.7-0.7-0.7-0.7-0.7-0.7-0.2-0.3
Time >=10cm from walls, locomotor time 10.60.61.00.90.60.71.00.81.00.80.90.90.90.4-0.0
Bouts of movement, locomotor time 10.00.00.20.30.10.10.30.10.50.10.20.20.2-0.1-0.1
Total resting periods, locomotor time 10.30.40.70.70.60.60.70.60.90.60.60.60.60.40.2
Rest time, locomotor task time 10.20.20.40.50.50.50.40.50.70.50.50.50.50.3-0.4
Distance moved, locomotor task time 10.40.51.2-1.1-0.9-0.8-0.6-0.9-0.8-0.8-0.6-0.7-0.7-0.6-0.1
Vertical activity count, locomotor time 10.40.91.3-0.8-1.0-1.0-0.8-0.9-0.9-1.1-0.9-0.9-1.0-1.1-0.5
Time >=10cm from walls, locomotor time 21.21.72.91.71.31.31.41.41.51.31.21.31.30.90.8
Bouts of movement, locomotor time 20.00.00.10.0-0.1-0.1-0.1-0.1-0.1-0.1-0.3-0.3-0.3-0.2-0.3
Total resting periods, locomotor time 20.00.00.00.10.10.00.10.10.00.0-0.1-0.1-0.1-0.0-0.1
Rest time, locomotor task time 20.10.10.30.30.30.40.20.40.40.40.50.50.50.3-0.1
Distance moved, locomotor task time 20.80.91.3-0.9-1.0-1.0-0.7-1.1-0.8-1.1-1.0-1.0-1.0-1.0-0.6
Vertical activity count, locomotor time 20.10.10.4-0.1-0.4-0.40.1-0.4-0.0-0.5-0.2-0.4-0.4-0.6-0.3
Light reinforcement 10.00.10.3-0.1-0.3-0.3-0.2-0.3-0.3-0.4-0.2-0.3-0.4-0.5-0.5
Light reinforcement 20.20.31.11.00.60.60.40.50.40.30.40.30.20.20.6
Bone: marrow area1.02.22.61.41.51.51.61.51.41.51.41.51.51.51.4
Bone: maximum diameter0.30.61.20.60.90.80.80.80.60.90.70.70.81.10.5
Bone: maximum force0.10.20.3-0.4-0.4-0.4-0.3-0.4-0.3-0.4-0.6-0.6-0.5-0.3-0.4
Bone: maximum moment0.00.10.1-0.2-0.2-0.2-0.1-0.2-0.2-0.2-0.4-0.4-0.3-0.2-0.2
Mean time between licks in bursts0.10.10.6-0.4-0.1-0.10.7-0.10.80.10.30.30.00.2-0.3
Mean num. licks in bursts2.23.45.02.22.02.01.71.91.71.81.91.91.81.61.6
Cd content in liver0.20.30.70.20.30.40.80.40.70.50.60.60.60.40.4
Co content in liver0.00.00.40.60.20.20.10.10.1-0.0-0.1-0.1-0.1-0.2-0.1
Cu content in liver0.10.10.20.20.10.30.30.30.20.40.40.40.40.10.5
Fe content in liver2.83.43.71.91.91.91.91.81.91.81.81.81.81.81.6
K content in liver0.20.20.5-0.7-0.3-0.4-0.5-0.4-0.5-0.2-0.3-0.3-0.30.1-0.3
Mg content in liver0.00.00.10.00.10.1-0.10.10.00.20.10.10.10.10.3
Mn content in liver0.50.50.8-0.5-0.8-0.7-0.9-0.6-0.7-0.7-0.7-0.7-0.7-0.9-0.6
Na content in liver0.10.10.40.60.50.40.20.30.20.20.30.30.30.40.2
Rb content in liver1.61.92.80.81.31.31.51.31.61.51.41.41.41.71.3
Se content in liver0.50.60.9-0.8-0.8-0.8-0.6-0.8-0.7-0.8-0.8-0.8-0.8-0.9-1.0
Sr content in liver0.80.71.21.10.80.90.90.90.90.80.80.80.80.50.8
Zn content in liver0.50.61.5-1.2-0.9-0.9-0.7-0.8-0.6-0.7-0.6-0.6-0.6-0.5-0.7
Bone: minimum diameter0.61.01.7-1.3-1.0-1.0-1.1-1.0-1.2-0.9-1.0-1.0-0.9-0.7-1.0
Time in familiar zone, hab. session 10.80.81.1-1.0-1.0-0.9-0.7-0.9-0.7-0.9-0.9-0.9-0.8-0.9-0.9
Time in novel zone, hab. session 10.30.30.50.30.50.50.40.50.60.60.70.70.60.60.6
Total zone transitions, hab. session 10.20.30.50.50.60.50.70.50.70.50.70.60.50.50.2
Total locomotion distance, hab. session 10.00.00.20.40.20.20.10.20.30.10.30.20.10.0-0.0
Locomotion velocity, hab. session 10.00.00.20.40.20.10.10.00.0-0.00.20.1-0.1-0.1-0.2
Time in familiar zone, hab. session 20.00.00.00.2-0.00.10.00.1-0.2-0.00.10.00.1-0.10.0
Time in novel zone, hab. session 20.00.00.10.00.10.10.10.20.20.20.20.20.20.20.1
Total zone transitions, hab. session 21.01.31.80.91.11.11.21.11.11.11.31.31.11.20.7
Total locomotion distance, hab. session 21.21.52.10.91.21.21.31.21.31.31.51.41.31.30.9
Locomotion velocity, hab. session 21.31.72.30.91.31.21.41.21.41.31.51.51.31.51.0
Novel to familiar place preference ratio0.00.00.1-0.1-0.1-0.0-0.2-0.1-0.1-0.0-0.1-0.10.1-0.1-0.4
Novelty place preference0.20.30.6-0.6-0.5-0.5-0.5-0.5-0.4-0.4-0.5-0.5-0.3-0.4-0.8
Time in novel zone, NPP test0.10.10.3-0.4-0.3-0.3-0.3-0.3-0.2-0.2-0.4-0.3-0.1-0.3-0.6
Total zone transitions, NPP test1.62.33.31.31.51.41.81.41.81.51.61.61.41.51.2
Total locomotion distance, NPP test2.02.83.31.71.71.71.71.61.81.61.81.71.61.51.5
Locomotion velocity, NPP test1.62.32.71.51.61.51.61.41.61.51.61.61.41.51.2
Intraocular pressure0.30.50.9-1.0-0.9-0.8-0.7-0.7-0.6-0.6-0.6-0.6-0.6-0.7-0.4
Delta distance traveled before/after self-admin0.20.20.7-0.8-0.4-0.5-0.2-0.6-0.2-0.4-0.4-0.4-0.4-0.1-0.6
Delta ambulatory time before/after self-admin0.10.10.10.20.30.30.30.20.30.30.30.30.30.3-0.1
Parametrial fat weight10.224.147.6-6.9-5.6-5.4-5.0-5.2-4.6-4.7-4.3-4.3-4.4-3.8-4.0
Pavlov. Cond. lever latency0.20.30.4-0.5-0.5-0.5-0.6-0.5-0.6-0.5-0.6-0.6-0.5-0.5-0.3
Pavlov. Cond. magazine entry latency0.50.60.90.60.70.80.80.80.80.80.90.90.90.80.6
Pavlov. Cond. change in total contacts0.00.00.30.2-0.3-0.1-0.1-0.0-0.1-0.2-0.0-0.0-0.1-0.5-0.0
Pavlov. Cond. index score0.30.30.50.50.50.60.50.60.50.60.70.70.60.50.4
Pavlov. Cond. latency score0.50.60.90.70.70.80.80.80.80.81.00.90.90.70.6
Pavlov. Cond. lever contacts0.00.00.10.20.10.20.20.20.20.10.20.20.10.10.1
Pavlov. Cond. magazine entry number1.01.31.7-1.0-1.1-1.2-1.1-1.2-1.2-1.2-1.3-1.3-1.2-1.1-1.0
Pavlov. Cond. intertrial magazine entries0.30.40.80.90.70.70.30.70.30.50.50.50.50.40.9
Pavlov. Cond. lever-magazine prob. diff.0.30.40.60.70.60.70.60.70.60.60.80.70.70.50.5
Pavlov. Cond. response bias0.81.01.31.01.01.01.01.11.01.01.11.11.00.91.0
Pavlov. Cond. lever latency0.50.71.1-0.8-0.9-0.7-1.0-0.7-1.1-0.7-0.8-0.8-0.6-0.8-0.6
Pavlov. Cond. magazine entry latency0.50.60.80.50.70.70.80.70.90.70.90.90.60.90.8
Pavlov. Cond. change in total contacts0.10.20.60.20.40.30.80.20.80.40.40.40.20.50.3
Pavlov. Cond. index score0.40.61.10.60.80.71.00.61.00.70.80.80.50.80.6
Pavlov. Cond. latency score0.60.81.30.81.00.81.10.81.10.80.90.90.71.00.8
Pavlov. Cond. lever contacts0.20.30.60.40.60.40.80.40.80.50.50.50.30.70.4
Pavlov. Cond. magazine entry number0.50.60.9-0.3-0.7-0.6-0.8-0.6-1.0-0.7-0.9-0.9-0.6-0.9-0.7
Pavlov. Cond. intertrial magazine entries1.32.02.7-1.2-1.6-1.4-1.5-1.3-1.5-1.4-1.4-1.4-1.4-1.6-1.1
Pavlov. Cond. lever-magazine prob. diff.0.50.61.20.60.80.71.10.61.10.70.80.80.50.90.7
Pavlov. Cond. response bias0.70.91.50.81.00.91.20.81.20.90.90.90.71.00.8
Time in closed arm before self-admin0.10.20.50.10.40.30.50.30.60.30.30.30.30.70.5
Time in closed arm after self-admin0.80.91.6-1.3-0.8-0.9-1.0-1.0-0.9-0.9-1.0-1.0-0.9-0.5-0.8
Time in open arm before self-admin0.40.50.8-0.4-0.7-0.7-0.7-0.7-0.8-0.7-0.7-0.7-0.7-0.9-0.5
Time in open arm after self-admin0.00.00.10.30.10.10.30.20.20.20.20.20.2-0.1-0.1
Bone: periosteal estimation0.20.50.60.70.80.80.60.70.40.80.60.60.70.80.5
Bone: periosteal perimeter0.20.30.80.30.70.60.60.50.40.70.60.60.70.90.1
Bone: post-yield work1.82.63.11.71.71.61.81.61.71.51.51.51.51.61.7
Progressive ratio test 1 active lever presses0.50.61.2-0.3-0.5-0.5-1.1-0.7-1.1-0.8-0.7-0.7-0.7-0.8-0.7
Progressive ratio test 1 breakpoint0.30.30.9-0.1-0.4-0.3-0.9-0.5-0.9-0.6-0.5-0.5-0.5-0.6-0.6
Progressive ratio test 1 inactive lever presses0.00.00.20.20.20.1-0.3-0.1-0.2-0.1-0.1-0.1-0.00.1-0.4
Progressive ratio test 2 active lever presses0.30.41.10.5-0.3-0.3-0.9-0.3-0.6-0.6-0.6-0.6-0.6-1.0-0.4
Progressive ratio test 2 breakpoint0.50.61.50.3-0.5-0.4-1.0-0.5-0.8-0.8-0.8-0.8-0.8-1.2-0.6
Progressive ratio test 2 inactive lever presses0.10.11.01.00.50.40.10.30.20.10.10.10.10.00.2
Incentive Sensitization - Responses0.20.31.20.7-0.3-0.2-0.4-0.1-0.2-0.5-0.6-0.6-0.6-1.1-0.4
Incentive Sensitization - Breakpoint0.40.61.90.5-0.6-0.5-0.7-0.4-0.5-0.8-0.9-0.9-0.9-1.4-0.6
Sum of active levers in priming session hrs 5-60.30.31.40.40.40.50.30.60.50.50.40.40.40.41.2
Progressive ratio0.30.40.80.20.60.40.80.50.60.70.60.70.70.90.8
Food seeking constrained by brief footshock3.54.36.92.62.32.22.02.12.02.02.02.02.01.71.7
Seeking ratio, punishment vs. effort0.40.61.31.10.90.90.70.80.90.70.70.70.80.50.2
Retroperitoneal fat weight11.549.0100.9-10.0-7.9-7.8-6.7-7.4-6.6-6.5-6.2-6.3-6.3-5.2-5.9
Reaction time number correct0.20.30.50.60.60.60.60.50.60.60.70.70.70.40.2
Reaction time mean minus median0.20.51.0-0.7-1.0-0.7-0.7-0.6-0.4-0.6-0.5-0.5-0.5-1.0-0.7
Reaction time mean minus median AUC0.30.71.1-1.0-1.0-0.9-0.9-0.7-0.7-0.8-0.7-0.7-0.7-0.9-0.8
Reaction time num false alarms0.10.10.5-0.60.10.1-0.20.1-0.10.40.30.30.30.70.1
Reaction time num false alarms AUC0.10.10.6-0.8-0.2-0.2-0.6-0.1-0.50.10.00.00.00.4-0.2
Reaction time trials correct on left0.20.30.50.60.60.60.60.50.60.60.70.70.70.40.2
Reaction time trials on left0.10.30.40.60.50.50.60.50.60.50.60.60.70.40.2
Reaction time mean0.30.41.4-0.3-0.9-0.6-0.5-0.4-0.2-0.6-0.5-0.5-0.5-1.2-0.8
Reaction time mean AUC0.30.41.4-0.3-0.9-0.6-0.5-0.5-0.2-0.6-0.6-0.6-0.5-1.2-0.8
Median of all reaction times0.10.21.00.1-0.6-0.3-0.1-0.20.1-0.3-0.3-0.3-0.3-1.0-0.5
Reaction time omissions0.10.20.6-0.8-0.7-0.5-0.4-0.3-0.2-0.3-0.5-0.4-0.3-0.5-0.2
Reaction time false alarm rate0.40.51.4-1.2-0.6-0.7-1.1-0.6-1.0-0.4-0.5-0.5-0.6-0.1-0.5
Reaction time premature initiation rate0.50.61.00.60.90.70.60.60.80.81.01.00.91.00.5
Reaction time premature initiations0.71.21.81.01.11.00.91.01.11.01.31.31.21.10.7
Std. dev. reaction times0.20.40.9-0.6-0.9-0.6-0.7-0.4-0.3-0.5-0.4-0.4-0.4-0.9-0.5
Reaction time trials completed0.10.30.40.60.50.50.60.50.60.50.60.60.70.40.2
Reaction time trials AUC0.10.10.20.40.30.30.40.30.40.30.40.40.50.1-0.0
Run reversals in cocaine runway, females1.11.11.31.11.11.11.11.01.11.01.01.01.01.11.0
Run reversals in cocaine runway, males0.30.30.6-0.3-0.4-0.5-0.5-0.6-0.6-0.6-0.7-0.8-0.7-0.5-0.5
Latency to leave start box in cocaine runway7.28.29.22.62.92.92.72.92.73.03.03.03.02.92.5
Latency to leave start box in cocaine runway, F3.74.35.51.62.12.11.92.11.82.32.22.22.22.31.9
Latency to leave start box in cocaine runway, M4.44.14.62.12.02.12.02.12.12.12.12.12.11.71.7
Std. dev. time between licks in bursts0.10.10.30.10.20.20.60.20.60.40.40.40.30.3-0.6
Total sessions with >9 infusions0.70.81.7-0.0-0.7-0.6-1.2-0.7-1.1-1.0-1.0-1.0-0.9-1.3-0.5
Short access day 1 total inactive lever presses0.30.41.31.20.90.80.10.60.10.40.50.50.60.50.7
Short access day 10 total inactive lever presses1.74.05.91.51.91.92.41.92.42.02.12.12.12.01.6
Short access day 1 total infusions0.10.10.30.4-0.00.0-0.5-0.0-0.5-0.3-0.3-0.3-0.2-0.40.3
Short access day 10 total infusions0.10.10.20.40.00.1-0.3-0.0-0.3-0.3-0.2-0.2-0.2-0.4-0.0
Short access total infusions0.40.51.0-0.1-0.6-0.5-1.0-0.6-0.9-0.8-0.7-0.7-0.7-0.9-0.3
Short access day 1 locomotion0.50.61.1-0.2-0.7-0.5-1.1-0.6-1.0-0.8-0.8-0.8-0.8-1.0-0.3
Short access day 10 total locomotion0.10.20.80.3-0.3-0.2-0.4-0.2-0.5-0.5-0.5-0.5-0.5-0.9-0.2
Short access total locomotion1.21.42.8-0.2-1.0-0.8-1.5-0.9-1.4-1.3-1.3-1.3-1.2-1.7-0.6
One hour access (0.3 mA shock)0.80.93.51.91.01.10.51.20.60.80.70.70.70.31.1
Compulsive drug intake0.10.10.50.30.30.30.40.40.20.40.30.30.30.30.7
One hour access (shock baseline)0.10.21.31.10.40.4-0.10.40.10.00.10.10.1-0.30.1
Social response proportion0.50.61.2-0.3-0.6-0.6-1.1-0.6-1.1-0.7-0.7-0.7-0.7-0.9-0.7
Social responses0.00.00.3-0.2-0.1-0.1-0.2-0.1-0.30.0-0.1-0.1-0.1-0.1-0.5
Social time1.31.82.5-0.9-1.3-1.2-1.2-1.2-1.5-1.2-1.5-1.4-1.4-1.5-1.6
Soleus weight1.85.38.42.92.52.52.32.42.42.12.12.12.11.82.3
Bone: stiffness0.30.50.7-0.8-0.6-0.7-0.6-0.7-0.6-0.7-0.8-0.8-0.7-0.4-0.7
Tibialis anterior weight0.31.12.31.51.11.21.11.20.91.01.01.01.00.71.1
Time to tail flick, vehicle, before self-admin1.41.51.8-1.2-1.3-1.2-1.2-1.2-1.2-1.2-1.2-1.2-1.2-1.3-1.2
Time to tail flick, vehicle, after self-admin0.50.62.3-1.5-1.0-0.8-0.7-0.8-0.7-0.6-0.6-0.6-0.6-0.5-0.5
Time to tail flick, test, before self-admin0.50.51.2-0.2-0.7-0.5-1.1-0.6-0.9-0.8-0.8-0.8-0.8-1.0-0.2
Time to tail flick, test, after self-admin0.10.10.50.70.20.30.10.30.10.10.10.10.1-0.20.5
Delta time to tail flick, vehicle, before/after SA0.50.50.70.20.50.60.60.60.70.80.80.80.80.80.7
Delta time to tail flick, test, before/after SA1.61.62.91.71.41.31.31.41.21.31.21.21.21.01.1
Tibia length1.23.33.8-2.0-1.8-1.9-1.8-1.9-1.8-1.8-1.8-1.8-1.8-1.6-1.5
Ambulatory time before self-admin0.00.00.1-0.1-0.1-0.10.2-0.10.10.00.00.0-0.1-0.1-0.4
Ambulatory time after self-admin0.10.10.3-0.00.20.00.50.00.50.20.20.20.20.3-0.5
Bone: tissue strength1.51.52.1-1.1-1.4-1.3-1.1-1.2-1.0-1.3-1.2-1.2-1.3-1.4-1.2
Total heroin consumption1.21.43.61.91.21.21.01.31.21.01.11.11.10.51.3
Bone: trabecular number2.84.76.22.52.22.32.12.32.12.12.02.02.11.82.3
Bone: trabecular spacing3.04.04.4-2.0-2.0-2.0-1.9-2.1-1.9-2.0-2.0-2.0-2.0-1.9-2.1
Bone: trabecular thickness1.92.32.61.41.41.61.41.61.51.61.61.61.51.41.5
Bone: trabecular tissue density0.30.40.80.50.70.60.90.60.80.70.60.50.60.80.5
Water consumed over 24 hours0.40.50.70.50.60.70.70.70.70.80.80.80.80.70.8
Number of responses in last shaping day0.60.71.31.00.90.80.50.80.70.70.80.80.80.71.1