Hub : Genes

Aqp11

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Aqp11 0.56 0.11 0.0e+00 0.36 0.37 0.37 0.38 2.2e-42 1.3e-43 1.3e-43 7.9e-44
2 Adipose mRNA stability Aqp11 0.25 0.1 0.0e+00 0.13 0.13 0.13 0.13 2.1e-14 1.7e-14 3.5e-14 1.5e-14
3 pVTA gene expression Aqp11 0.28 0.13 1.4e-07 0.14 0.13 0.11 0.13 8.5e-07 2.2e-06 1.4e-05 2.2e-06
4 NAcc gene expression Aqp11 0.12 0.06 2.2e-13 0.12 0.11 0.11 0.12 8.8e-14 7.5e-13 5.5e-13 2.0e-13
5 PL gene expression Aqp11 0.15 0.09 5.9e-08 0.07 0.08 0.06 0.07 2.5e-08 8.9e-09 7.2e-07 2.9e-08
6 Adipose gene expression Aqp11 0.52 0.12 0.0e+00 0.23 0.32 0.32 0.32 3.5e-25 6.6e-37 1.9e-36 3.1e-36
7 Brain gene expression Aqp11 0.26 0.11 5.7e-11 0.11 0.12 0.1 0.11 3.1e-10 3.6e-11 7.9e-10 4.3e-10
8 LHb gene expression Aqp11 0.52 0.18 1.5e-05 0.04 0.16 0.19 0.12 3.9e-02 1.1e-04 3.6e-05 9.9e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.10.10.3-0.2-0.40.20.10.1-0.4-0.10.5
Area under the delay curve0.80.91.41.0-1.1-0.9-0.71.2-0.71.0-0.6
BMI with tail0.51.64.8-1.02.10.50.3-1.32.2-0.4-0.3
BMI without tail3.16.519.4-1.94.20.80.7-2.74.4-1.3-0.8
Body weight1.24.816.4-1.53.80.30.2-2.14.0-0.6-1.2
Weight adjusted by age1.01.13.50.50.4-1.1-1.00.31.31.0-1.9
Bone surface1.32.23.31.7-1.4-1.8-1.81.6-0.61.6-1.1
Bone volume0.81.42.11.2-0.8-1.4-1.51.3-0.01.4-1.1
Breakpoint value in progressive ratio session0.20.20.50.2-0.5-0.1-0.10.5-0.70.50.0
Number of licking bursts1.82.13.3-1.81.61.81.7-1.51.0-1.00.9
Context. condit. distance diff. score3.33.95.32.2-2.3-1.9-2.02.3-1.72.0-1.3
Locomotion velocity, session 10.60.71.90.7-1.4-0.2-0.20.9-1.40.40.1
Locomotion distance, session 10.30.41.00.8-0.9-0.3-0.40.6-1.00.30.1
Locomotion velocity, session 20.50.60.90.9-0.7-0.8-0.80.9-0.20.8-0.7
Locomotion distance, session 20.00.10.2-0.00.10.20.1-0.20.1-0.40.4
Locomotion velocity, session 30.20.30.40.6-0.7-0.6-0.50.6-0.50.4-0.3
Locomotion distance, session 32.12.33.61.7-1.9-1.5-1.41.8-1.51.3-0.5
Stereotopy head waving bouts, day 33.44.16.1-2.32.12.02.0-2.51.3-2.31.1
Stereotopy head waving duration, day 30.40.51.2-0.70.30.70.7-0.80.0-1.10.9
Locomotion velocity, session 70.50.61.10.7-0.8-0.6-0.61.0-0.41.0-0.6
Locomotion distance, session 71.41.83.51.3-0.9-1.4-1.41.5-0.11.9-1.5
Stereotopy head waving bouts, day 70.20.20.6-0.1-0.40.10.1-0.2-0.7-0.80.4
Stereotopy head waving duration, day 70.10.10.20.4-0.5-0.4-0.40.1-0.4-0.3-0.2
Locomotion velocity, session 86.67.911.73.0-3.4-2.7-2.73.4-2.22.9-1.8
Locomotion distance, session 81.31.92.71.6-1.6-1.3-1.51.6-1.11.2-0.8
Degree of sensitization distance0.70.82.9-0.31.4-0.0-0.0-0.61.70.2-0.9
Degree of sensitization stereotypy1.41.53.11.4-1.8-1.2-1.21.2-1.70.4-0.3
Conditioned locomotion0.10.10.3-0.0-0.40.30.20.1-0.5-0.10.4
Cocaine response after cond. corrected0.30.41.40.40.1-0.3-0.40.70.11.2-0.7
Cocaine response after cond. not corrected0.20.20.50.4-0.3-0.2-0.30.5-0.50.7-0.1
Cocaine response before conditioning0.81.02.5-0.6-0.30.80.8-0.9-1.0-1.61.5
Saline control response0.30.40.80.80.1-0.9-0.90.20.70.2-0.7
Bone: connectivity density0.40.72.00.6-1.4-0.3-0.40.8-1.40.40.4
Bone: cortical apparent density0.20.20.4-0.60.60.60.6-0.40.6-0.10.2
Bone: cortical area0.71.01.60.9-0.1-1.2-1.30.70.71.2-1.2
Bone: cortical porosity0.30.30.8-0.2-0.20.40.4-0.4-0.7-0.90.5
Bone: cortical porosity0.40.41.2-0.4-0.00.60.6-0.6-0.6-1.10.6
Bone: cortical thickness0.00.00.1-0.20.30.10.1-0.20.40.2-0.2
Bone: cortical thickness1.41.62.41.4-1.0-1.3-1.21.4-0.71.6-1.2
Bone: cortical tissue density0.20.30.4-0.60.60.60.7-0.40.6-0.20.3
Condit. Reinf. active minus inactive responses0.40.52.00.01.0-0.3-0.3-0.21.40.4-0.6
Condit. Reinf. active-inactive response ratio0.40.41.7-0.11.1-0.2-0.2-0.41.30.1-0.5
Condit. Reinf. active responses0.30.41.6-0.31.00.10.1-0.51.3-0.0-0.3
Condit. Reinf. inactive responses0.00.00.1-0.20.10.10.2-0.10.2-0.1-0.2
Incentive salience index mean0.50.61.10.50.5-0.7-0.70.41.10.9-1.0
Condit. Reinf. lever presses0.70.91.41.0-0.7-1.0-1.01.1-0.11.2-1.1
Condit. Reinf. active minus inactive responses3.44.27.72.5-0.9-2.8-2.81.70.51.9-2.1
Condit. Reinf. active-inactive response ratio2.62.73.91.9-1.1-2.0-2.01.7-0.11.9-1.5
Condit. Reinf. active responses3.75.19.92.7-0.6-3.1-3.11.70.92.0-2.5
Condit. Reinf. inactive responses0.70.91.70.80.8-1.2-1.1-0.11.3-0.0-1.2
Condit. Reinf. lever presses7.39.817.24.1-2.7-4.1-4.03.1-1.12.4-2.2
Condit. Reinf. lever reinforcers received4.25.811.23.0-0.9-3.3-3.31.90.72.1-2.5
Conditioned reinforcement - actives2.42.44.51.6-2.1-1.4-1.41.6-1.81.1-0.9
Conditioned reinforcement - inactives0.00.00.1-0.30.00.30.3-0.0-0.30.0-0.2
Conditioned locomotion1.82.14.31.4-2.1-1.3-1.31.5-1.91.0-0.7
Patch foraging indifference point 0 sec0.81.32.91.6-0.8-1.7-1.50.9-0.20.5-0.8
Patch foraging indifference point AUC0.20.20.40.50.0-0.5-0.40.40.30.6-0.7
Delay disc. indifference point, 0s delay0.30.30.90.6-0.1-0.7-0.70.40.10.4-1.0
Delay disc. indifference point, 16s delay0.60.61.50.8-1.2-0.4-0.31.0-1.00.60.0
Delay disc. indifference point, 2s delay0.50.61.00.9-0.8-1.0-0.90.8-0.50.6-0.6
Delay disc. indifference point, 24s delay0.10.10.30.2-0.5-0.00.10.6-0.30.60.3
Delay disc. indifference point, 4s delay1.51.62.91.2-0.6-1.5-1.41.20.11.4-1.7
Delay disc. indifference point, 8s delay1.11.11.81.2-1.3-0.9-0.81.3-0.91.1-0.6
Indifference point function ln k0.30.41.20.5-1.0-0.3-0.30.3-1.1-0.30.3
Indifference point function log k0.30.41.20.5-1.0-0.3-0.30.3-1.1-0.30.3
Patch foraging total patch changes 0 sec0.81.32.71.6-0.9-1.6-1.51.0-0.30.7-0.8
Patch foraging total patch changes 12 sec0.60.72.50.70.1-1.0-0.90.40.60.8-1.6
Patch foraging total patch changes 18 sec1.01.32.41.3-0.2-1.4-1.30.90.51.0-1.5
Patch foraging total patch changes 24 sec0.50.61.30.80.3-0.9-0.80.40.60.7-1.1
Patch foraging total patch changes 6 sec0.10.10.20.4-0.4-0.3-0.10.0-0.3-0.20.4
Patch foraging time to switch 0 sec2.33.66.0-2.51.52.42.4-1.90.4-1.71.5
Patch foraging water rate 0 sec1.72.84.62.1-1.5-2.0-2.11.7-0.81.3-1.4
Patch foraging water rate 12 sec1.11.73.01.7-1.4-1.6-1.61.4-0.80.9-0.6
Patch foraging water rate 18 sec0.91.21.81.4-0.6-1.3-1.31.2-0.01.1-1.1
Patch foraging water rate 24 sec1.01.42.61.3-1.6-0.9-1.01.5-1.50.9-0.2
Patch foraging water rate 6 sec0.50.81.61.0-1.3-0.8-0.81.0-1.10.4-0.2
Seeking ratio, delayed vs. immediate footshock0.10.10.4-0.2-0.00.30.20.3-0.10.6-0.3
Distance traveled before self-admin0.10.10.5-0.30.40.40.3-0.10.2-0.10.7
Distance traveled after self-admin1.41.63.2-1.20.51.51.5-1.1-0.3-1.41.8
Extensor digitorum longus weight0.20.92.60.30.7-0.7-0.70.41.41.1-1.6
Bone: elastic displacement0.10.20.3-0.4-0.20.60.5-0.0-0.40.00.5
Bone: elastic work0.40.61.7-0.2-1.00.60.60.3-1.30.10.8
Bone: endosteal estimation0.92.03.71.4-0.1-1.8-1.81.10.91.5-1.9
Bone: endosteal perimeter1.73.66.12.2-0.9-2.5-2.51.90.42.0-1.9
Epididymis fat weight1.43.29.9-1.53.10.60.4-1.63.1-0.2-1.2
Delta time in closed arm before/after self-admin0.80.81.50.80.3-0.7-0.70.71.21.2-1.0
Delta time in open arm before/after self-admin0.70.71.51.0-0.2-1.2-1.20.7-0.10.6-0.8
Diff in mean of infusions in LGA sessions1.81.93.5-1.91.31.71.7-1.40.8-1.00.9
Delay discount exponential model param0.70.81.3-1.01.10.80.7-1.10.7-0.90.5
Extinction: sum of active levers before priming0.30.30.60.50.1-0.6-0.50.50.50.7-0.5
Active lever presses in extinction session 60.40.41.60.5-0.5-0.1-0.10.1-1.3-0.70.7
Bone: final force0.30.40.70.7-0.8-0.6-0.60.7-0.60.8-0.1
Bone: final moment0.30.40.60.7-0.8-0.6-0.70.7-0.50.8-0.2
Food consumed during 24 hour testing period0.70.91.91.0-1.4-0.9-0.90.9-1.10.1-0.3
Glucose0.50.71.10.8-0.9-0.9-0.91.0-0.41.1-0.5
Heart weight0.81.22.21.5-0.9-1.3-1.21.2-0.51.1-0.7
Delay discount hyperbolic model param0.91.01.5-1.11.11.00.9-1.20.6-1.10.8
Intermittent access intake day 1-15 change1.61.52.91.4-1.7-1.2-1.21.4-1.40.8-0.2
Intermittent access intake escalation1.91.93.21.6-1.8-1.4-1.41.5-1.40.9-0.4
Intermittent access intake escalation 20.30.30.50.6-0.5-0.7-0.70.5-0.30.4-0.5
Intermitt. access day 1 inactive lever presses0.50.61.1-1.00.90.90.8-0.80.3-0.70.1
Intermitt. access day 15 inactive lever presses0.00.00.1-0.0-0.10.10.30.1-0.3-0.00.2
Intermitt. access escalation Index0.30.30.5-0.70.20.60.5-0.6-0.1-0.60.6
Intermittent access day 1 total infusions1.11.31.81.2-0.9-1.3-1.31.2-0.31.3-1.1
Intermittent access day 15 total infusions2.93.34.82.0-2.2-1.9-1.92.0-1.51.6-1.1
Intermittent access terminal intake (last 3 days)1.61.82.41.3-1.4-1.5-1.51.4-0.81.3-1.3
Intermittent access total infusions1.31.41.91.1-1.1-1.3-1.31.2-0.61.3-1.4
Intermittent access day 1 locomotion0.30.30.80.2-0.9-0.4-0.40.5-0.90.5-0.3
Intermittent access day 15 total locomotion1.11.21.91.3-1.2-1.4-1.31.1-0.80.9-0.8
Intermittent access total locomotion0.60.71.10.7-0.7-1.0-1.00.8-0.30.8-1.0
Intermittent access standard deviation0.10.10.4-0.00.2-0.2-0.20.00.10.2-0.6
Left kidney weight0.61.75.10.31.4-1.0-1.0-0.22.30.4-2.1
Right kidney weight0.41.14.1-0.11.6-0.4-0.4-0.62.0-0.2-1.3
Cocaine induced anxiety1.01.12.0-1.30.71.41.4-1.10.5-0.90.8
Post-drug Anxiety0.10.10.2-0.20.30.50.5-0.10.3-0.10.2
Baseline Anxiety1.92.03.51.9-1.3-1.6-1.61.6-0.81.3-0.9
Tail length1.44.316.3-0.33.3-0.8-0.8-1.44.0-0.2-2.1
Length with tail1.03.612.9-0.93.2-0.2-0.2-1.63.6-0.5-1.5
Length without tail0.00.10.2-0.40.00.40.4-0.2-0.2-0.10.5
Times rat made contact with spout0.91.01.7-1.21.30.90.8-1.21.2-0.90.1
Lifetime Intake1.41.61.91.3-1.2-1.4-1.31.3-0.71.3-1.3
Liver weight, left0.40.61.8-0.81.20.20.1-0.81.4-0.20.0
Liver weight, right3.35.411.0-2.73.31.61.6-2.83.1-1.60.2
Locomotor activity0.60.92.3-0.61.00.70.7-1.21.0-1.50.3
Locomotor testing distance0.40.61.70.60.8-0.6-0.6-0.21.3-0.2-1.1
Locomotor testing rearing0.91.55.3-0.31.90.1-0.0-1.12.3-0.4-1.1
Locomotion in novel chamber0.81.04.00.6-2.0-0.4-0.60.7-1.50.30.2
Locomotion in novel chamber post-restriction2.93.58.31.9-2.9-1.5-1.72.0-2.31.2-0.0
Fecal boli incidents, locomotor time 12.52.74.22.0-1.9-1.6-1.51.9-1.51.5-1.0
Change in fecal boli incidents, locomotor task2.01.92.7-1.51.11.61.6-1.40.5-1.41.5
Time >=10cm from walls, locomotor time 10.90.92.01.0-1.3-0.8-0.90.9-1.40.30.1
Bouts of movement, locomotor time 10.40.50.70.9-0.7-0.8-0.70.9-0.30.70.2
Total resting periods, locomotor time 10.50.51.00.7-1.0-0.6-0.50.9-0.70.60.5
Rest time, locomotor task time 10.50.61.40.8-1.2-0.3-0.40.9-1.10.60.3
Distance moved, locomotor task time 10.70.72.30.10.9-0.6-0.5-0.11.30.4-1.5
Vertical activity count, locomotor time 10.30.31.00.10.6-0.5-0.5-0.00.90.3-1.0
Time >=10cm from walls, locomotor time 20.80.91.71.1-0.5-1.3-1.30.8-0.20.8-0.7
Bouts of movement, locomotor time 20.10.10.30.10.3-0.3-0.2-0.10.4-0.2-0.6
Total resting periods, locomotor time 20.00.00.20.10.2-0.2-0.1-0.10.2-0.2-0.4
Rest time, locomotor task time 21.11.22.4-1.20.51.61.5-1.0-0.3-1.01.1
Distance moved, locomotor task time 21.92.24.21.5-0.3-1.9-1.91.10.61.5-2.0
Vertical activity count, locomotor time 21.41.53.71.00.2-1.5-1.40.81.01.3-1.9
Light reinforcement 11.22.33.1-1.71.81.61.6-1.71.0-1.21.2
Light reinforcement 20.30.51.1-0.50.10.60.7-0.8-0.3-0.91.1
Bone: marrow area0.81.73.11.3-0.0-1.6-1.60.90.91.3-1.8
Bone: maximum diameter1.42.64.71.8-0.7-2.1-2.21.40.31.7-1.7
Bone: maximum force0.61.02.01.0-1.4-0.9-1.01.2-1.01.1-0.1
Bone: maximum moment0.61.01.81.0-1.4-1.0-1.01.1-0.91.1-0.2
Mean time between licks in bursts1.72.36.91.30.3-1.8-1.90.71.41.0-2.6
Mean num. licks in bursts1.31.62.71.5-1.2-1.6-1.61.3-0.60.9-1.0
Cd content in liver0.30.30.8-0.50.80.40.4-0.40.90.1-0.2
Co content in liver1.41.62.61.3-0.1-1.5-1.51.20.71.5-1.6
Cu content in liver0.70.92.40.60.8-0.8-0.80.21.40.6-1.5
Fe content in liver0.70.91.70.9-0.5-0.9-0.91.0-0.21.2-1.3
K content in liver1.00.91.3-1.11.01.11.0-1.10.8-1.10.4
Mg content in liver0.00.00.00.10.1-0.1-0.1-0.00.1-0.1-0.1
Mn content in liver0.70.81.3-0.9-0.21.21.1-0.5-0.8-0.81.1
Na content in liver0.50.61.6-0.6-0.10.80.7-0.7-0.9-1.30.5
Rb content in liver0.60.71.20.9-0.2-1.1-1.10.80.51.0-0.9
Se content in liver1.72.04.0-1.80.82.02.0-1.3-0.0-1.31.0
Sr content in liver0.70.71.10.8-1.0-0.7-0.71.0-0.70.9-0.4
Zn content in liver1.01.12.21.4-0.3-1.5-1.50.80.20.6-1.2
Bone: minimum diameter0.61.22.70.70.7-1.1-1.10.31.71.1-1.5
Time in familiar zone, hab. session 10.10.10.10.2-0.2-0.3-0.20.3-0.10.4-0.4
Time in novel zone, hab. session 10.30.30.7-0.40.90.40.4-0.50.8-0.3-0.0
Total zone transitions, hab. session 10.81.23.9-0.6-0.51.00.9-0.7-1.0-1.32.0
Total locomotion distance, hab. session 15.37.511.9-3.03.52.62.6-3.42.5-2.61.1
Locomotion velocity, hab. session 14.86.810.4-2.93.22.52.5-3.22.2-2.51.2
Time in familiar zone, hab. session 20.70.71.80.7-0.2-1.0-1.00.80.50.8-1.3
Time in novel zone, hab. session 20.10.10.20.3-0.2-0.1-0.10.2-0.40.20.3
Total zone transitions, hab. session 20.50.62.30.1-0.60.20.3-0.3-1.0-0.91.5
Total locomotion distance, hab. session 23.24.27.6-2.12.71.71.8-2.62.2-1.90.8
Locomotion velocity, hab. session 23.54.78.5-2.22.91.81.9-2.72.3-2.00.9
Novel to familiar place preference ratio0.10.10.4-0.30.10.30.2-0.5-0.2-0.50.6
Novelty place preference0.00.00.1-0.10.10.10.0-0.2-0.1-0.20.3
Time in novel zone, NPP test0.00.00.10.2-0.2-0.2-0.20.1-0.30.00.1
Total zone transitions, NPP test0.40.61.70.6-1.3-0.2-0.20.7-1.30.20.7
Total locomotion distance, NPP test1.82.55.2-1.72.31.41.4-1.91.8-1.10.2
Locomotion velocity, NPP test2.53.56.7-2.02.61.81.8-2.31.9-1.40.5
Intraocular pressure4.56.310.02.7-3.0-2.4-2.33.2-2.02.7-1.2
Delta distance traveled before/after self-admin0.60.71.7-0.70.20.90.9-0.9-0.2-1.30.8
Delta ambulatory time before/after self-admin0.60.71.3-0.5-0.30.80.9-0.6-0.7-1.21.2
Parametrial fat weight1.22.33.9-1.62.01.11.2-2.01.7-1.30.9
Pavlov. Cond. lever latency0.81.12.0-1.10.71.11.2-1.00.1-1.01.4
Pavlov. Cond. magazine entry latency1.01.32.21.3-0.5-1.5-1.50.90.31.0-1.5
Pavlov. Cond. change in total contacts1.61.73.31.3-0.8-1.4-1.51.2-0.21.4-1.8
Pavlov. Cond. index score1.62.14.61.5-0.5-1.7-1.71.20.51.4-2.1
Pavlov. Cond. latency score1.41.84.11.4-0.5-1.6-1.61.20.41.3-2.0
Pavlov. Cond. lever contacts1.11.33.51.1-0.4-1.2-1.21.00.41.2-1.9
Pavlov. Cond. magazine entry number1.51.82.9-1.60.71.71.7-1.2-0.2-1.21.7
Pavlov. Cond. intertrial magazine entries0.70.91.4-1.21.01.11.1-1.00.6-0.80.5
Pavlov. Cond. lever-magazine prob. diff.1.41.84.11.4-0.6-1.5-1.61.20.31.3-2.0
Pavlov. Cond. response bias0.60.82.30.9-0.2-0.9-0.90.70.50.8-1.5
Pavlov. Cond. lever latency9.913.423.3-4.83.44.54.5-3.81.6-3.02.5
Pavlov. Cond. magazine entry latency4.95.79.13.0-2.8-2.5-2.52.7-1.92.0-0.8
Pavlov. Cond. change in total contacts5.98.214.33.8-2.6-3.6-3.62.8-1.32.2-1.8
Pavlov. Cond. index score9.011.619.54.4-3.3-4.1-4.13.6-1.72.9-2.1
Pavlov. Cond. latency score8.510.517.94.2-3.3-3.9-3.83.4-1.82.7-1.9
Pavlov. Cond. lever contacts8.711.921.04.6-3.1-4.4-4.33.5-1.52.7-2.4
Pavlov. Cond. magazine entry number11.113.620.0-4.53.84.14.1-4.22.2-3.72.2
Pavlov. Cond. intertrial magazine entries2.12.76.5-1.42.50.90.9-1.92.4-1.3-0.5
Pavlov. Cond. lever-magazine prob. diff.8.610.918.34.3-3.1-4.0-4.03.4-1.62.8-2.2
Pavlov. Cond. response bias10.514.224.34.9-3.5-4.7-4.63.9-1.73.1-2.7
Time in closed arm before self-admin0.40.52.20.2-1.00.10.20.1-1.5-0.60.5
Time in closed arm after self-admin0.91.03.20.7-1.8-0.2-0.11.1-1.60.60.1
Time in open arm before self-admin0.91.01.4-1.11.21.21.2-0.91.0-0.50.6
Time in open arm after self-admin0.40.41.7-0.31.1-0.1-0.1-0.61.3-0.1-0.2
Bone: periosteal estimation1.63.35.11.9-0.5-2.2-2.31.60.72.1-2.2
Bone: periosteal perimeter1.01.62.91.4-0.3-1.7-1.71.10.71.3-1.2
Bone: post-yield work0.10.10.40.0-0.60.00.1-0.1-0.5-0.30.6
Progressive ratio test 1 active lever presses0.10.10.1-0.3-0.30.30.3-0.1-0.3-0.10.1
Progressive ratio test 1 breakpoint0.10.10.1-0.4-0.20.30.4-0.2-0.3-0.20.2
Progressive ratio test 1 inactive lever presses0.00.00.20.20.0-0.1-0.20.1-0.00.1-0.5
Progressive ratio test 2 active lever presses2.22.33.61.5-0.7-1.9-1.91.5-0.01.7-1.9
Progressive ratio test 2 breakpoint1.51.73.11.2-0.4-1.6-1.61.20.11.4-1.8
Progressive ratio test 2 inactive lever presses0.91.12.31.0-0.6-1.1-1.11.0-0.11.1-1.5
Incentive Sensitization - Responses2.52.64.31.6-0.5-2.1-2.01.50.21.7-2.1
Incentive Sensitization - Breakpoint2.32.43.91.5-0.5-2.0-2.01.40.11.6-2.0
Sum of active levers in priming session hrs 5-60.40.40.8-0.60.90.40.5-0.70.5-0.70.3
Progressive ratio1.31.53.41.3-1.8-0.8-0.71.5-1.31.20.0
Food seeking constrained by brief footshock0.20.30.80.60.6-0.5-0.6-0.20.9-0.3-0.2
Seeking ratio, punishment vs. effort1.51.85.6-0.92.40.40.2-1.61.9-1.2-0.5
Retroperitoneal fat weight3.310.933.1-3.15.41.41.3-3.15.8-0.7-1.1
Reaction time number correct1.01.42.9-0.80.01.21.3-1.0-0.8-1.71.7
Reaction time mean minus median0.10.20.40.40.1-0.5-0.6-0.00.70.0-0.2
Reaction time mean minus median AUC0.10.10.20.4-0.3-0.4-0.5-0.10.1-0.20.2
Reaction time num false alarms0.40.51.1-0.81.00.70.8-0.51.00.1-0.0
Reaction time num false alarms AUC0.10.10.2-0.40.30.40.5-0.00.40.3-0.2
Reaction time trials correct on left1.01.42.9-0.80.01.21.3-1.0-0.8-1.71.7
Reaction time trials on left1.01.42.9-0.80.01.21.3-1.0-0.8-1.71.7
Reaction time mean0.20.30.5-0.50.70.50.5-0.70.5-0.40.2
Reaction time mean AUC0.10.20.3-0.50.50.50.5-0.50.3-0.20.4
Median of all reaction times0.20.30.5-0.60.60.70.7-0.60.1-0.40.3
Reaction time omissions0.10.20.40.40.3-0.3-0.50.20.40.5-0.6
Reaction time false alarm rate0.20.31.30.00.2-0.2-0.10.50.61.1-0.8
Reaction time premature initiation rate1.21.65.2-0.22.0-0.5-0.4-0.82.3-0.1-1.5
Reaction time premature initiations0.70.92.6-0.41.60.10.1-1.11.5-0.8-0.7
Std. dev. reaction times0.20.31.40.20.7-0.4-0.4-0.21.20.2-0.6
Reaction time trials completed1.01.42.9-0.80.01.21.3-1.0-0.8-1.71.7
Reaction time trials AUC0.91.32.8-0.80.21.11.2-1.1-0.6-1.71.5
Run reversals in cocaine runway, females1.71.65.50.11.7-0.5-0.70.12.31.1-1.6
Run reversals in cocaine runway, males1.71.62.81.3-1.6-1.1-1.01.7-1.21.4-0.5
Latency to leave start box in cocaine runway1.31.42.1-1.41.31.31.4-1.40.6-1.10.8
Latency to leave start box in cocaine runway, F0.70.81.7-0.91.30.80.9-1.01.0-0.6-0.1
Latency to leave start box in cocaine runway, M1.21.11.9-1.10.21.21.2-0.9-0.6-1.21.4
Std. dev. time between licks in bursts0.91.03.5-0.51.60.20.1-1.01.9-0.7-0.7
Total sessions with >9 infusions0.60.71.20.9-1.1-0.7-0.70.8-1.00.4-0.7
Short access day 1 total inactive lever presses0.30.40.60.6-0.6-0.5-0.40.8-0.40.8-0.6
Short access day 10 total inactive lever presses1.41.51.9-1.41.21.21.3-1.40.5-1.41.3
Short access day 1 total infusions0.80.81.41.2-0.7-1.1-1.10.8-0.50.7-1.1
Short access day 10 total infusions1.31.42.41.3-0.9-1.3-1.31.2-0.31.3-1.5
Short access total infusions0.50.61.10.8-0.6-0.8-0.80.7-0.30.8-1.0
Short access day 1 locomotion1.71.83.91.5-1.9-1.0-1.01.5-2.00.8-0.0
Short access day 10 total locomotion0.10.10.20.2-0.1-0.4-0.50.20.00.2-0.5
Short access total locomotion0.10.10.2-0.3-0.10.40.3-0.3-0.5-0.40.2
One hour access (0.3 mA shock)1.82.23.91.6-0.7-1.8-1.71.4-0.11.5-2.0
Compulsive drug intake0.00.00.1-0.20.20.30.2-0.2-0.1-0.30.1
One hour access (shock baseline)1.11.21.91.2-0.9-1.4-1.31.2-0.41.0-1.2
Social response proportion2.32.53.8-1.91.71.71.6-2.01.0-1.70.7
Social responses1.62.04.4-1.42.11.31.1-1.51.9-0.90.1
Social time1.72.33.5-1.71.31.91.8-1.60.4-1.41.5
Soleus weight0.51.56.0-0.61.8-0.00.0-0.82.40.2-1.4
Bone: stiffness0.10.10.20.1-0.4-0.1-0.10.2-0.40.40.3
Tibialis anterior weight0.10.30.8-0.30.90.00.0-0.60.9-0.3-0.3
Time to tail flick, vehicle, before self-admin0.40.51.4-0.61.20.60.5-0.60.8-0.40.2
Time to tail flick, vehicle, after self-admin1.41.52.51.6-1.5-1.3-1.21.4-1.00.8-0.5
Time to tail flick, test, before self-admin0.80.81.51.0-0.7-1.0-1.01.0-0.21.2-0.6
Time to tail flick, test, after self-admin1.21.21.81.3-0.3-1.3-1.31.10.41.2-1.3
Delta time to tail flick, vehicle, before/after SA2.42.45.31.8-2.3-1.4-1.31.7-1.80.9-0.2
Delta time to tail flick, test, before/after SA0.20.20.5-0.40.30.40.5-0.50.1-0.70.5
Tibia length0.51.32.51.4-1.6-1.1-1.21.1-1.40.5-0.0
Ambulatory time before self-admin0.10.10.30.0-0.30.1-0.00.4-0.40.40.6
Ambulatory time after self-admin1.01.13.2-0.8-0.31.21.1-0.6-0.9-1.01.8
Bone: tissue strength1.71.63.7-1.2-0.41.41.3-0.9-1.2-1.31.9
Total heroin consumption0.00.00.10.2-0.3-0.1-0.10.2-0.30.10.2
Bone: trabecular number0.20.30.6-0.5-0.50.60.60.0-0.7-0.00.8
Bone: trabecular spacing0.20.20.60.8-0.4-0.7-0.60.3-0.4-0.1-0.3
Bone: trabecular thickness0.10.20.80.00.3-0.1-0.20.20.90.6-0.2
Bone: trabecular tissue density1.82.54.0-1.72.01.41.4-1.91.9-1.30.7
Water consumed over 24 hours1.01.32.1-1.40.91.41.4-1.20.4-1.20.8
Number of responses in last shaping day0.60.62.0-0.31.40.00.0-0.61.2-0.0-1.1