Aqp11

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression Aqp11 0.05 0.04 7.0e-03 0.02 0.05 0.01 0.03 3.3e-02 1.1e-03 6.2e-02 9.4e-03
2 IC gene expression Aqp11 0.1 0.07 2.8e-03 0.06 0.07 0.05 0.06 1.8e-03 9.1e-04 3.1e-03 1.9e-03
3 Liver gene expression Aqp11 0.54 0.12 0.0e+00 0.36 0.37 0.36 0.37 1.2e-41 2.4e-43 5.2e-42 4.5e-43
4 NAcc gene expression Aqp11 0.08 0.04 2.6e-13 0.1 0.09 0.09 0.09 9.4e-15 1.5e-13 3.2e-13 1.7e-13
5 pVTA gene expression Aqp11 0.25 0.14 3.4e-14 0.18 0.17 0.16 0.18 2.5e-14 8.0e-14 5.4e-13 3.1e-14
6 PL gene expression Aqp11 0.16 0.09 7.6e-09 0.07 0.08 0.06 0.07 2.2e-08 3.8e-09 1.4e-07 2.5e-08
7 Adipose mRNA stability Aqp11 0.25 0.1 0.0e+00 0.14 0.14 0.12 0.13 8.3e-15 4.2e-15 3.2e-13 1.1e-14
8 Adipose gene expression Aqp11 0.49 0.12 0.0e+00 0.27 0.33 0.31 0.32 8.0e-30 1.2e-37 1.9e-34 2.6e-36
9 Brain gene expression Aqp11 0.24 0.11 6.5e-11 0.11 0.12 0.1 0.1 1.8e-10 2.6e-11 5.8e-10 1.1e-09
10 LHb gene expression Aqp11 0.49 0.18 1.6e-05 0.05 0.16 0.14 0.11 2.3e-02 1.3e-04 3.5e-04 1.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density0.00.10.2-0.30.0-0.3-0.5-0.4-0.0-0.3-0.3-0.1-0.3
Area under the delay curve0.80.91.51.01.21.00.90.81.2-0.9-0.71.00.5
BMI with tail1.24.012.5-0.8-2.8-1.1-0.6-0.4-1.73.53.5-0.41.4
BMI without tail1.75.217.1-0.6-3.0-1.1-0.4-0.2-1.94.14.1-0.51.6
Body weight1.66.821.1-1.1-3.7-1.6-0.4-0.7-2.64.64.5-0.91.4
Weight adjusted by age0.40.51.50.5-0.30.50.90.60.20.91.00.71.2
Bone surface1.22.13.11.81.41.81.51.81.6-0.6-0.51.61.4
Bone volume0.61.21.81.20.81.21.21.31.1-0.10.11.31.3
Breakpoint value in progressive ratio session0.30.30.6-0.70.0-0.5-0.8-0.6-0.2-0.6-0.7-0.4-0.8
Number of licking bursts1.62.54.2-2.0-2.0-2.0-2.0-1.8-1.51.11.0-1.0-0.7
Context. condit. distance diff. score3.34.05.42.12.32.32.12.02.3-1.7-1.62.11.2
Locomotion velocity, session 10.70.82.20.51.20.60.60.30.9-1.5-1.40.4-0.3
Locomotion distance, session 10.30.40.90.70.90.70.40.40.6-0.9-1.00.2-0.2
Locomotion velocity, session 20.60.71.21.00.81.01.10.90.9-0.3-0.20.80.7
Locomotion distance, session 20.00.10.20.1-0.0-0.10.2-0.2-0.30.20.2-0.5-0.3
Locomotion velocity, session 30.30.30.50.60.70.60.60.50.6-0.5-0.40.50.3
Locomotion distance, session 32.02.13.71.41.91.61.01.31.7-1.7-1.61.30.5
Stereotopy head waving bouts, day 33.23.76.2-2.0-2.2-2.2-1.5-2.0-2.51.61.3-2.3-1.4
Stereotopy head waving duration, day 30.30.41.2-0.5-0.4-0.6-0.2-0.6-0.90.20.2-1.1-0.9
Locomotion velocity, session 70.40.41.00.40.70.60.60.50.9-0.6-0.51.00.6
Locomotion distance, session 71.11.43.21.10.91.20.81.31.5-0.4-0.21.81.5
Stereotopy head waving bouts, day 70.40.41.00.30.80.30.50.00.0-0.9-1.0-0.6-0.9
Stereotopy head waving duration, day 70.30.30.80.70.70.60.90.40.1-0.5-0.5-0.3-0.3
Locomotion velocity, session 86.47.711.52.83.33.02.72.73.4-2.6-2.13.01.7
Locomotion distance, session 81.52.13.11.71.81.71.71.41.6-1.2-1.11.30.8
Degree of sensitization distance0.80.82.8-0.2-1.2-0.40.10.1-0.61.71.70.20.9
Degree of sensitization stereotypy1.71.83.71.51.91.51.31.11.2-1.7-1.70.4-0.2
Conditioned locomotion0.10.10.4-0.20.3-0.20.1-0.40.0-0.5-0.4-0.3-0.6
Cocaine response after cond. corrected0.30.31.40.30.10.40.20.40.80.00.01.21.0
Cocaine response after cond. not corrected0.20.20.60.30.40.50.00.20.6-0.5-0.60.80.4
Cocaine response before conditioning0.80.92.8-0.50.2-0.5-0.6-0.8-0.9-0.8-1.1-1.4-1.7
Saline control response0.20.20.60.80.20.50.50.70.00.40.5-0.00.3
Bone: connectivity density0.40.61.70.41.00.50.30.20.7-1.3-1.30.4-0.2
Bone: cortical apparent density0.20.30.9-0.7-0.6-0.7-1.0-0.7-0.30.30.3-0.2-0.2
Bone: cortical area0.50.72.10.8-0.10.70.41.00.50.70.71.11.4
Bone: cortical porosity0.30.30.9-0.20.2-0.2-0.2-0.3-0.4-0.5-0.7-0.8-1.0
Bone: cortical porosity0.40.41.3-0.30.1-0.3-0.2-0.5-0.6-0.5-0.7-1.0-1.1
Bone: cortical thickness0.10.20.5-0.5-0.6-0.4-0.7-0.3-0.20.40.30.30.3
Bone: cortical thickness0.70.81.70.90.61.00.51.01.1-0.3-0.31.31.1
Bone: cortical tissue density0.20.30.9-0.8-0.5-0.7-1.0-0.7-0.30.20.2-0.3-0.3
Condit. Reinf. active minus inactive responses0.50.61.90.1-0.8-0.0-0.00.4-0.21.31.40.41.0
Condit. Reinf. active-inactive response ratio0.40.41.60.1-0.8-0.10.00.3-0.41.21.20.10.7
Condit. Reinf. active responses0.40.41.5-0.3-0.9-0.4-0.1-0.1-0.41.21.2-0.00.5
Condit. Reinf. inactive responses0.00.00.1-0.2-0.2-0.20.1-0.2-0.10.20.2-0.00.0
Incentive salience index mean0.50.61.70.5-0.30.40.60.70.40.91.00.91.3
Condit. Reinf. lever presses0.60.81.30.90.81.01.10.91.1-0.3-0.11.21.0
Condit. Reinf. active minus inactive responses3.03.87.52.71.42.52.12.71.60.30.51.92.2
Condit. Reinf. active-inactive response ratio1.82.13.51.81.11.71.21.81.6-0.10.11.91.8
Condit. Reinf. active responses3.65.010.03.21.42.82.63.01.60.70.91.92.5
Condit. Reinf. inactive responses0.81.02.71.40.11.01.61.2-0.21.21.2-0.10.8
Condit. Reinf. lever presses7.910.921.74.73.54.34.04.23.0-1.2-0.92.62.3
Condit. Reinf. lever reinforcers received4.15.711.63.41.63.02.83.31.80.50.72.12.6
Conditioned reinforcement - actives0.81.32.11.31.51.41.21.11.1-1.1-1.20.90.5
Conditioned reinforcement - inactives0.30.40.9-0.50.3-0.4-0.2-0.6-0.2-0.9-1.0-0.5-0.9
Conditioned locomotion1.92.55.01.52.21.71.31.21.4-2.1-2.20.8-0.0
Patch foraging indifference point 0 sec0.71.43.21.81.21.51.81.50.7-0.3-0.20.50.6
Patch foraging indifference point AUC0.20.40.80.60.20.60.60.80.50.30.30.80.9
Delay disc. indifference point, 0s delay0.60.71.51.10.61.11.21.10.60.10.10.70.9
Delay disc. indifference point, 16s delay0.50.61.30.51.10.60.60.31.1-1.1-0.90.7-0.0
Delay disc. indifference point, 2s delay0.70.81.31.21.01.11.11.00.8-0.6-0.60.60.5
Delay disc. indifference point, 24s delay0.10.10.2-0.30.1-0.2-0.5-0.40.4-0.4-0.20.40.0
Delay disc. indifference point, 4s delay2.12.24.11.81.11.72.01.81.4-0.10.21.71.7
Delay disc. indifference point, 8s delay0.80.91.60.91.21.01.00.71.3-1.0-0.81.00.5
Indifference point function ln k0.30.51.20.51.00.40.70.00.2-1.1-1.1-0.4-0.8
Indifference point function log k0.30.51.20.51.00.40.70.00.2-1.1-1.1-0.4-0.8
Patch foraging total patch changes 0 sec0.81.53.31.81.31.61.81.50.9-0.4-0.30.70.6
Patch foraging total patch changes 12 sec0.50.71.80.90.10.81.40.90.30.70.70.61.1
Patch foraging total patch changes 18 sec1.11.73.21.70.61.51.81.80.90.50.71.11.6
Patch foraging total patch changes 24 sec0.30.51.00.80.00.70.61.00.30.70.70.51.0
Patch foraging total patch changes 6 sec0.10.10.30.60.50.40.40.40.1-0.3-0.4-0.0-0.2
Patch foraging time to switch 0 sec1.73.56.5-2.5-1.8-2.4-2.2-2.3-1.80.50.3-1.7-1.6
Patch foraging water rate 0 sec1.42.95.32.31.82.22.22.01.6-0.8-0.71.41.2
Patch foraging water rate 12 sec0.71.42.61.61.61.51.41.41.2-0.9-0.70.80.4
Patch foraging water rate 18 sec0.71.02.21.30.91.21.51.11.1-0.20.11.00.9
Patch foraging water rate 24 sec1.21.63.11.31.81.31.41.01.4-1.5-1.30.90.1
Patch foraging water rate 6 sec0.50.71.50.91.20.90.90.70.9-1.1-1.00.4-0.1
Seeking ratio, delayed vs. immediate footshock0.10.10.3-0.5-0.2-0.2-0.2-0.30.2-0.1-0.10.50.3
Distance traveled before self-admin0.20.31.2-0.6-0.5-0.6-1.1-0.4-0.30.20.2-0.3-0.3
Distance traveled after self-admin1.92.44.2-1.8-0.9-1.7-2.0-1.8-1.5-0.3-0.6-1.8-2.0
Extensor digitorum longus weight0.31.12.60.4-0.70.21.00.60.21.41.61.11.6
Bone: elastic displacement0.20.20.4-0.6-0.1-0.5-0.7-0.50.1-0.5-0.50.1-0.4
Bone: elastic work0.50.61.6-0.70.4-0.4-1.0-0.60.4-1.3-1.20.1-0.8
Bone: endosteal estimation0.92.14.11.70.41.51.71.81.00.91.11.42.0
Bone: endosteal perimeter1.83.86.22.51.32.22.52.51.70.30.62.02.3
Epididymis fat weight0.72.45.2-1.4-2.3-1.5-1.4-1.0-1.72.22.0-0.70.3
Delta time in closed arm before/after self-admin0.60.51.40.4-0.00.30.20.60.90.40.91.21.2
Delta time in open arm before/after self-admin1.41.42.61.60.91.51.51.50.9-0.00.01.11.2
Diff in mean of infusions in LGA sessions2.73.36.1-2.5-1.7-2.4-2.4-2.1-1.70.40.3-1.6-1.6
Delay discount exponential model param0.70.81.4-0.9-1.1-1.0-0.8-0.7-1.20.90.8-1.0-0.5
Extinction: sum of active levers before priming0.20.20.60.60.10.40.40.50.30.40.60.50.7
Active lever presses in extinction session 61.11.13.4-0.00.8-0.1-0.2-0.4-0.4-1.4-1.7-1.3-1.8
Bone: final force0.20.40.80.40.60.6-0.20.50.8-0.7-0.70.90.4
Bone: final moment0.20.30.70.50.60.6-0.20.50.7-0.6-0.60.80.4
Food consumed during 24 hour testing period0.91.32.71.31.61.21.60.90.8-1.3-1.10.1-0.2
Glucose0.50.81.90.90.40.90.71.10.90.10.31.41.4
Heart weight0.10.20.50.70.50.60.40.60.5-0.2-0.10.50.3
Delay discount hyperbolic model param0.91.01.6-1.1-1.1-1.1-1.1-1.0-1.30.80.6-1.1-0.8
Intermittent access intake day 1-15 change0.61.22.51.21.61.21.10.81.0-1.4-1.40.4-0.2
Intermittent access intake escalation0.81.73.41.41.91.41.11.01.2-1.6-1.60.7-0.0
Intermittent access intake escalation 20.50.61.10.91.00.90.80.60.6-0.8-0.90.30.1
Intermitt. access day 1 inactive lever presses0.31.02.0-1.4-0.6-1.2-1.2-1.3-0.8-0.3-0.4-0.9-1.1
Intermitt. access day 15 inactive lever presses0.81.62.8-1.7-1.0-1.6-1.5-1.7-1.10.0-0.1-1.2-1.4
Intermitt. access escalation Index0.20.20.7-0.30.3-0.2-0.5-0.30.1-0.8-0.8-0.1-0.6
Intermittent access day 1 total infusions0.71.21.61.21.31.21.21.11.2-0.9-0.71.10.7
Intermittent access day 15 total infusions2.33.45.82.02.42.01.91.71.9-2.0-1.91.40.6
Intermittent access terminal intake (last 3 days)1.51.93.21.61.71.61.81.31.3-1.3-1.21.00.6
Intermittent access total infusions1.41.73.01.51.41.51.71.31.3-0.9-0.81.21.0
Intermittent access day 1 locomotion0.40.51.20.51.00.60.60.50.7-1.1-1.00.5-0.0
Intermittent access day 15 total locomotion0.40.81.60.91.20.91.00.60.5-1.2-1.20.0-0.4
Intermittent access total locomotion0.40.51.10.80.90.81.10.70.5-0.7-0.70.40.2
Intermittent access standard deviation0.20.30.80.4-0.40.20.70.4-0.20.90.90.20.7
Left kidney weight0.62.99.2-0.5-2.2-0.90.3-0.3-1.73.03.0-0.90.8
Right kidney weight0.62.99.8-0.3-2.2-0.70.5-0.2-1.73.13.1-0.81.0
Cocaine induced anxiety1.21.72.6-1.6-1.5-1.6-1.3-1.5-1.40.90.9-1.0-0.7
Post-drug Anxiety0.40.50.9-0.9-0.8-0.9-0.8-0.9-0.50.40.6-0.3-0.3
Baseline Anxiety1.11.32.21.31.31.31.11.21.5-0.7-0.51.30.9
Tail length0.83.312.20.3-2.0-0.20.60.6-1.13.43.5-0.01.8
Length with tail0.93.812.6-0.5-2.6-1.00.1-0.2-1.93.53.5-0.71.2
Length without tail0.72.34.1-1.5-1.9-1.7-1.2-1.5-2.01.41.1-1.6-0.9
Times rat made contact with spout0.80.91.6-0.9-1.3-1.0-0.5-0.8-1.11.21.2-0.9-0.2
Lifetime Intake1.72.13.31.61.71.71.81.41.5-1.2-1.11.30.8
Liver weight, left0.50.82.5-0.3-1.2-0.3-0.2-0.0-0.81.61.4-0.00.8
Liver weight, right2.44.110.8-1.4-2.9-1.6-0.7-1.0-2.23.33.1-0.90.8
Locomotor activity0.50.82.2-0.4-0.7-0.70.3-0.7-1.21.01.0-1.5-0.8
Locomotor testing distance0.50.93.00.6-0.60.21.20.5-0.51.61.7-0.40.6
Locomotor testing rearing0.91.75.8-0.2-1.7-0.60.2-0.0-1.22.42.4-0.60.7
Locomotion in novel chamber1.01.32.81.01.61.10.90.90.9-1.6-1.70.6-0.1
Locomotion in novel chamber post-restriction2.03.36.32.02.52.01.41.71.8-2.2-2.01.20.3
Fecal boli incidents, locomotor time 11.62.33.81.51.91.71.31.21.9-1.6-1.61.40.6
Change in fecal boli incidents, locomotor task1.61.52.4-1.4-1.2-1.5-1.3-1.4-1.40.50.5-1.4-1.2
Time >=10cm from walls, locomotor time 11.31.42.61.21.61.21.01.01.1-1.5-1.50.6-0.1
Bouts of movement, locomotor time 10.40.50.90.90.80.80.40.70.9-0.4-0.20.80.6
Total resting periods, locomotor time 10.40.40.80.60.90.60.10.50.9-0.8-0.60.70.2
Rest time, locomotor task time 10.50.61.70.41.10.60.10.41.0-1.3-1.20.7-0.1
Distance moved, locomotor task time 10.50.71.80.4-0.60.30.90.5-0.11.31.30.41.2
Vertical activity count, locomotor time 10.20.41.00.5-0.30.40.80.60.10.91.00.41.0
Time >=10cm from walls, locomotor time 20.71.12.31.30.91.31.01.51.0-0.1-0.11.01.1
Bouts of movement, locomotor time 20.10.21.00.50.10.31.00.3-0.10.40.4-0.10.2
Total resting periods, locomotor time 20.10.10.80.40.10.30.90.2-0.00.20.2-0.10.1
Rest time, locomotor task time 20.81.02.0-1.4-0.8-1.3-1.3-1.1-0.9-0.1-0.3-0.9-1.1
Distance moved, locomotor task time 21.82.13.61.90.81.71.91.81.10.50.61.41.9
Vertical activity count, locomotor time 21.01.42.91.30.31.21.61.30.80.80.91.21.7
Light reinforcement 10.81.94.0-1.6-1.7-1.5-2.0-1.2-1.41.21.0-1.0-0.6
Light reinforcement 20.20.41.1-0.5-0.3-0.5-1.0-0.6-0.7-0.0-0.3-0.8-0.8
Bone: marrow area0.81.73.61.50.31.31.61.70.90.91.11.31.9
Bone: maximum diameter1.12.13.91.90.81.71.72.01.10.40.61.51.8
Bone: maximum force0.40.81.30.71.00.8-0.20.71.0-1.1-1.11.10.4
Bone: maximum moment0.40.71.00.71.00.8-0.10.71.0-1.0-1.01.00.4
Mean time between licks in bursts0.81.94.71.70.21.42.21.70.41.31.40.71.7
Mean num. licks in bursts1.32.03.71.91.61.81.91.71.3-0.8-0.61.00.9
Cd content in liver0.40.41.3-0.1-0.8-0.2-0.30.1-0.11.01.20.50.8
Co content in liver0.81.01.81.10.31.01.31.20.70.50.71.01.3
Cu content in liver1.01.24.60.2-1.1-0.10.60.3-0.52.02.10.11.1
Fe content in liver0.10.10.20.20.10.30.40.20.3-0.1-0.20.40.3
K content in liver0.70.71.4-0.9-0.8-0.9-0.4-0.9-1.00.50.4-1.2-0.8
Mg content in liver0.10.10.4-0.1-0.0-0.20.1-0.3-0.4-0.0-0.0-0.6-0.5
Mn content in liver0.70.81.7-1.0-0.0-0.8-1.1-1.0-0.5-0.8-1.0-0.8-1.3
Na content in liver0.40.41.3-0.20.2-0.20.1-0.5-0.6-0.5-0.8-1.1-1.1
Rb content in liver0.10.10.3-0.0-0.3-0.10.10.1-0.20.40.5-0.10.1
Se content in liver2.32.85.4-2.3-1.4-2.1-2.0-2.2-1.50.0-0.2-1.5-1.6
Sr content in liver0.60.50.70.70.90.80.40.70.9-0.7-0.70.70.3
Zn content in liver1.21.43.11.30.01.01.81.30.41.21.40.71.5
Bone: minimum diameter0.71.33.50.8-0.60.60.61.10.31.61.81.01.9
Time in familiar zone, hab. session 10.10.00.10.10.20.20.20.20.3-0.1-0.10.40.3
Time in novel zone, hab. session 10.30.30.7-0.4-0.8-0.5-0.4-0.3-0.50.80.9-0.30.1
Total zone transitions, hab. session 10.70.92.6-0.70.0-0.8-1.3-1.0-0.7-0.7-0.9-1.2-1.6
Total locomotion distance, hab. session 15.37.512.2-2.7-3.5-2.9-2.5-2.6-3.42.92.5-2.6-1.1
Locomotion velocity, hab. session 14.76.610.4-2.6-3.2-2.7-2.4-2.5-3.22.72.2-2.6-1.2
Time in familiar zone, hab. session 20.70.72.01.00.50.81.40.90.70.20.50.81.0
Time in novel zone, hab. session 20.10.10.20.10.20.2-0.30.20.2-0.3-0.50.30.0
Total zone transitions, hab. session 20.40.51.6-0.10.4-0.2-0.8-0.4-0.4-0.8-0.9-0.9-1.3
Total locomotion distance, hab. session 23.44.47.4-1.9-2.7-2.1-1.8-1.8-2.62.52.2-2.0-0.7
Locomotion velocity, hab. session 23.74.98.3-1.9-2.9-2.2-2.0-1.9-2.72.72.3-2.1-0.7
Novel to familiar place preference ratio0.10.10.3-0.2-0.1-0.2-0.5-0.2-0.4-0.0-0.2-0.5-0.5
Novelty place preference0.00.00.00.0-0.0-0.0-0.20.0-0.2-0.0-0.1-0.2-0.2
Time in novel zone, NPP test0.00.00.10.30.30.30.10.30.1-0.2-0.20.1-0.0
Total zone transitions, NPP test0.40.51.60.31.00.4-0.20.20.7-1.3-1.20.2-0.5
Total locomotion distance, NPP test2.02.75.2-1.6-2.3-1.6-1.5-1.4-1.92.01.7-1.2-0.2
Locomotion velocity, NPP test2.73.76.9-2.0-2.6-2.0-2.0-1.7-2.32.21.8-1.5-0.4
Intraocular pressure4.15.89.62.32.92.62.02.23.1-2.4-2.02.61.4
Delta distance traveled before/after self-admin0.80.92.7-0.7-0.1-0.7-0.2-1.0-1.0-0.4-0.6-1.5-1.6
Delta ambulatory time before/after self-admin0.60.72.4-0.50.1-0.6-0.2-0.9-0.7-0.7-0.8-1.3-1.6
Parametrial fat weight1.02.54.1-1.6-1.8-1.7-2.0-1.5-1.91.20.9-1.5-1.0
Pavlov. Cond. lever latency1.11.43.0-1.4-1.0-1.4-1.7-1.4-1.20.30.1-1.2-1.2
Pavlov. Cond. magazine entry latency1.11.52.91.60.81.51.71.60.90.20.31.11.3
Pavlov. Cond. change in total contacts1.41.52.41.41.01.51.61.51.3-0.3-0.31.41.3
Pavlov. Cond. index score1.51.94.31.70.91.62.11.71.20.20.41.31.6
Pavlov. Cond. latency score1.31.73.51.60.91.51.91.61.10.10.31.21.5
Pavlov. Cond. lever contacts0.91.12.71.20.71.11.61.21.00.10.31.11.2
Pavlov. Cond. magazine entry number1.41.83.8-1.7-0.9-1.5-1.9-1.7-1.1-0.2-0.4-1.2-1.4
Pavlov. Cond. intertrial magazine entries0.80.91.6-1.3-1.1-1.2-1.0-1.1-1.00.60.5-0.9-0.6
Pavlov. Cond. lever-magazine prob. diff.1.41.73.81.60.91.52.01.61.20.00.31.31.4
Pavlov. Cond. response bias0.80.92.61.10.61.01.61.10.90.20.40.91.1
Pavlov. Cond. lever latency10.113.725.3-5.0-4.1-4.7-4.5-4.5-3.61.91.5-2.9-2.3
Pavlov. Cond. magazine entry latency5.06.09.12.93.02.92.22.72.8-2.1-1.82.21.2
Pavlov. Cond. change in total contacts5.18.216.04.03.03.73.53.62.7-1.2-0.92.32.0
Pavlov. Cond. index score8.811.920.94.63.84.33.94.23.5-1.9-1.52.92.2
Pavlov. Cond. latency score8.110.818.64.33.84.13.73.93.4-2.0-1.62.82.0
Pavlov. Cond. lever contacts9.112.523.44.83.84.54.44.33.4-1.6-1.22.82.3
Pavlov. Cond. magazine entry number10.713.218.5-4.3-4.0-4.3-3.7-4.1-4.22.41.9-3.8-2.6
Pavlov. Cond. intertrial magazine entries1.62.45.8-1.0-2.1-1.2-0.5-0.9-1.92.42.2-1.30.0
Pavlov. Cond. lever-magazine prob. diff.8.511.419.94.53.74.23.94.13.4-1.8-1.42.92.2
Pavlov. Cond. response bias11.215.326.95.24.24.94.74.73.9-1.9-1.53.32.6
Time in closed arm before self-admin0.30.31.00.10.70.10.5-0.20.1-0.9-1.0-0.4-0.8
Time in closed arm after self-admin0.70.72.5-0.01.00.20.1-0.10.9-1.6-1.40.5-0.5
Time in open arm before self-admin1.01.12.2-1.3-1.3-1.2-1.5-1.1-0.90.80.7-0.7-0.4
Time in open arm after self-admin0.40.51.70.1-0.8-0.1-0.10.2-0.61.31.2-0.20.6
Bone: periosteal estimation1.32.75.81.90.61.81.72.11.30.70.92.02.4
Bone: periosteal perimeter0.91.52.71.50.41.21.41.60.80.81.11.11.6
Bone: post-yield work0.10.10.3-0.20.0-0.2-0.6-0.3-0.3-0.3-0.4-0.4-0.5
Progressive ratio test 1 active lever presses0.30.31.10.10.70.2-0.1-0.10.5-1.1-1.10.2-0.4
Progressive ratio test 1 breakpoint0.30.31.20.10.80.3-0.00.00.5-1.1-1.10.3-0.3
Progressive ratio test 1 inactive lever presses0.50.71.6-1.0-0.1-0.8-0.9-1.1-0.5-0.7-0.8-0.8-1.2
Progressive ratio test 2 active lever presses1.61.92.71.61.21.61.61.61.4-0.5-0.41.61.4
Progressive ratio test 2 breakpoint1.82.02.91.61.31.71.61.61.5-0.6-0.51.61.4
Progressive ratio test 2 inactive lever presses0.20.30.80.60.50.60.90.40.5-0.4-0.30.50.4
Incentive Sensitization - Responses1.31.93.71.71.01.61.91.71.2-0.00.11.41.5
Incentive Sensitization - Breakpoint1.31.73.51.61.01.61.91.61.1-0.00.01.31.4
Sum of active levers in priming session hrs 5-60.60.51.3-0.5-0.7-0.7-0.5-0.6-1.10.60.4-1.1-0.7
Progressive ratio1.11.83.21.21.71.40.71.01.8-1.5-1.41.40.6
Food seeking constrained by brief footshock0.30.40.90.8-0.10.50.50.8-0.31.01.0-0.30.4
Seeking ratio, punishment vs. effort1.42.05.3-0.6-1.8-0.9-0.2-0.5-2.02.32.0-1.5-0.1
Retroperitoneal fat weight3.314.032.2-2.9-5.4-3.3-2.6-2.0-3.95.75.4-1.71.0
Reaction time number correct0.71.43.8-1.0-0.2-1.0-1.0-1.4-1.1-0.5-0.7-1.7-2.0
Reaction time mean minus median0.10.30.60.80.10.60.60.70.10.50.60.20.6
Reaction time mean minus median AUC0.10.10.50.70.30.50.50.40.10.10.1-0.00.1
Reaction time num false alarms0.50.81.6-1.1-1.2-1.0-0.9-0.8-0.51.01.10.00.3
Reaction time num false alarms AUC0.10.20.3-0.6-0.6-0.5-0.3-0.4-0.00.40.50.30.3
Reaction time trials correct on left0.71.43.8-1.0-0.2-1.0-1.0-1.4-1.1-0.5-0.7-1.7-2.0
Reaction time trials on left0.71.43.8-1.0-0.2-1.0-1.0-1.4-1.1-0.5-0.7-1.7-2.0
Reaction time mean0.20.20.5-0.5-0.7-0.5-0.5-0.4-0.60.60.5-0.3-0.1
Reaction time mean AUC0.10.20.3-0.5-0.5-0.5-0.6-0.4-0.40.30.2-0.2-0.1
Median of all reaction times0.20.30.6-0.7-0.7-0.7-0.8-0.6-0.60.40.2-0.4-0.3
Reaction time omissions0.20.30.70.6-0.10.50.50.80.30.60.70.50.8
Reaction time false alarm rate0.30.41.4-0.1-0.40.0-0.00.20.50.50.61.11.2
Reaction time premature initiation rate1.11.55.40.4-1.30.10.70.5-0.82.32.3-0.01.3
Reaction time premature initiations0.50.92.90.0-1.1-0.30.4-0.1-1.11.71.6-0.70.3
Std. dev. reaction times0.20.41.20.5-0.40.30.50.6-0.11.11.10.30.9
Reaction time trials completed0.71.43.8-1.0-0.2-1.0-1.0-1.4-1.1-0.5-0.7-1.7-2.0
Reaction time trials AUC0.71.23.3-0.9-0.3-1.0-0.9-1.3-1.1-0.3-0.5-1.7-1.8
Run reversals in cocaine runway, females1.31.34.40.1-1.1-0.00.30.5-0.01.92.10.81.6
Run reversals in cocaine runway, males1.51.52.81.11.61.21.00.91.7-1.5-1.21.40.5
Latency to leave start box in cocaine runway1.92.23.3-1.8-1.7-1.7-1.7-1.8-1.61.00.7-1.3-0.9
Latency to leave start box in cocaine runway, F1.82.13.8-1.6-1.9-1.6-1.3-1.6-1.51.61.4-1.0-0.3
Latency to leave start box in cocaine runway, M0.40.40.8-0.6-0.0-0.5-0.6-0.7-0.4-0.5-0.6-0.6-0.9
Std. dev. time between licks in bursts0.91.24.1-0.1-1.3-0.40.2-0.1-1.22.02.0-0.80.4
Total sessions with >9 infusions1.21.52.21.41.51.51.51.11.2-1.1-1.10.90.5
Short access day 1 total inactive lever presses0.50.71.10.81.00.90.80.61.1-0.7-0.60.90.4
Short access day 10 total inactive lever presses1.02.53.9-1.9-1.5-2.0-1.7-1.9-1.70.60.5-1.7-1.6
Short access day 1 total infusions1.41.93.61.81.41.81.91.71.2-0.5-0.51.11.1
Short access day 10 total infusions1.62.02.91.61.51.71.51.51.6-0.9-0.71.51.2
Short access total infusions1.82.33.51.71.81.81.91.51.6-1.2-1.11.30.8
Short access day 1 locomotion2.32.85.21.92.31.91.41.61.8-1.9-1.71.20.4
Short access day 10 total locomotion0.61.12.41.41.11.31.61.30.9-0.4-0.30.80.8
Short access total locomotion0.30.40.90.60.90.60.60.40.4-0.9-1.00.0-0.3
One hour access (0.3 mA shock)0.91.01.71.31.01.21.21.21.0-0.3-0.21.00.9
Compulsive drug intake0.70.91.7-1.1-0.5-1.0-1.1-1.1-0.9-0.2-0.4-1.2-1.3
One hour access (shock baseline)1.62.53.51.91.71.91.81.71.7-1.0-0.91.51.1
Social response proportion2.62.94.7-1.9-2.0-2.0-1.4-1.8-2.21.41.1-1.9-1.2
Social responses1.62.14.0-1.3-2.0-1.5-1.1-1.1-1.62.01.9-1.0-0.1
Social time1.92.64.4-2.1-1.6-2.0-2.1-1.9-1.60.70.5-1.5-1.3
Soleus weight0.72.06.6-0.7-2.0-0.9-0.1-0.4-1.12.52.6-0.21.0
Bone: stiffness0.10.21.2-0.40.0-0.2-1.1-0.30.0-0.5-0.60.2-0.2
Tibialis anterior weight0.10.41.2-0.2-0.8-0.40.0-0.3-0.81.11.0-0.50.1
Time to tail flick, vehicle, before self-admin0.10.10.20.2-0.00.20.20.30.30.20.30.40.5
Time to tail flick, vehicle, after self-admin0.60.81.61.11.01.01.31.00.9-0.5-0.30.70.5
Time to tail flick, test, before self-admin1.11.12.41.10.61.10.81.21.10.10.31.51.5
Time to tail flick, test, after self-admin0.50.61.30.70.00.60.90.80.60.60.80.81.1
Delta time to tail flick, vehicle, before/after SA0.70.71.30.91.20.91.00.70.8-1.0-0.90.4-0.1
Delta time to tail flick, test, before/after SA1.01.11.9-1.1-0.9-1.2-1.0-1.2-1.20.40.2-1.4-1.2
Tibia length0.51.32.51.31.61.40.71.21.0-1.3-1.40.60.1
Ambulatory time before self-admin0.20.21.1-0.40.1-0.3-1.0-0.30.1-0.6-0.60.0-0.4
Ambulatory time after self-admin1.31.63.8-1.2-0.2-1.1-1.5-1.4-0.9-0.9-1.1-1.5-1.9
Bone: tissue strength2.02.14.1-1.5-0.3-1.3-2.0-1.5-1.1-1.0-1.3-1.4-2.0
Total heroin consumption0.00.00.1-0.3-0.3-0.3-0.2-0.1-0.30.20.1-0.3-0.2
Bone: trabecular number0.20.30.6-0.8-0.1-0.6-0.5-0.70.0-0.6-0.50.0-0.4
Bone: trabecular spacing0.20.30.50.70.70.70.50.50.3-0.4-0.5-0.1-0.2
Bone: trabecular thickness0.20.31.1-0.2-0.7-0.3-0.2-0.0-0.10.81.10.40.7
Bone: trabecular tissue density2.63.95.6-2.0-2.4-2.2-2.2-2.0-2.31.81.7-1.8-1.0
Water consumed over 24 hours0.50.61.2-1.1-0.8-1.1-0.5-1.0-0.80.40.4-0.8-0.7
Number of responses in last shaping day1.21.43.3-1.0-1.7-1.0-0.8-0.5-1.01.81.7-0.30.6