Hub : Genes

Hspa12a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Hspa12a 0.07 0.06 6.8e-06 0.02 0.03 0.03 0.02 1.6e-03 4.6e-05 2.2e-05 1.1e-04
2 pVTA mRNA stability Hspa12a 0.19 0.09 5.6e-11 0.09 0.14 0.12 0.12 1.1e-07 5.4e-11 1.1e-09 6.9e-10
3 Adipose gene expression Hspa12a 0.43 0.14 0.0e+00 0.26 0.27 0.28 0.28 9.4e-29 5.4e-30 2.4e-31 1.5e-30
4 OFC gene expression Hspa12a 0.26 0.14 1.6e-04 0.04 0.16 0.12 0.11 5.2e-02 1.2e-04 9.3e-04 1.5e-03
5 NAcc mRNA stability Hspa12a 0.07 0.06 5.1e-06 0.04 0.04 0.04 0.04 4.0e-07 4.0e-06 5.1e-07 7.2e-07
6 Brain gene expression Hspa12a 0.11 0.06 1.3e-07 0.06 0.09 0.09 0.08 1.1e-06 1.5e-08 1.5e-08 4.0e-08
7 OFC mRNA stability Hspa12a 0.17 0.11 8.0e-03 0.07 0.05 0.01 0.04 8.3e-03 2.7e-02 1.4e-01 4.1e-02
8 Adipose alternative TSS XM_063288270.1 0.07 0.06 2.3e-03 0.02 0 0.01 0.01 5.6e-03 8.8e-02 1.2e-02 4.4e-02
9 Adipose mRNA stability Hspa12a 0.27 0.12 0.0e+00 0.13 0.16 0.17 0.17 4.9e-14 4.8e-17 2.3e-18 1.2e-18
10 pVTA intron excision ratio chr1_268068664_268071439 0.13 0.13 8.6e-03 0 0.01 0.01 0 1.7e-01 6.1e-02 8.3e-02 1.1e-01
11 IC mRNA stability Hspa12a 0.11 0.07 2.1e-04 0.08 0.08 0.05 0.09 2.9e-04 4.4e-04 3.2e-03 1.6e-04
12 Brain mRNA stability Hspa12a 0.13 0.09 3.7e-06 0.03 0.06 0.06 0.05 8.6e-04 1.6e-06 4.3e-06 1.1e-05
13 Liver gene expression Hspa12a 0.04 0.03 1.9e-05 0.04 0.04 0.03 0.04 6.8e-05 8.4e-05 8.5e-04 7.9e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density1.93.36.02.41.4-2.4-1.32.1-0.81.9-1.9-2.01.32.11.4-1.7
Area under the delay curve1.01.13.9-0.41.6-0.2-1.50.5-2.00.5-0.50.21.4-0.21.01.1
BMI with tail3.813.234.05.84.8-4.0-4.33.6-4.33.4-3.4-2.62.92.52.3-0.5
BMI without tail2.16.622.64.83.2-2.9-2.92.4-2.82.3-2.3-1.81.71.81.3-0.7
Body weight5.122.347.06.95.6-5.5-5.24.9-4.74.8-4.8-4.13.93.93.5-1.6
Weight adjusted by age0.30.42.61.60.9-0.6-0.70.4-1.00.2-0.2-0.10.40.10.00.1
Bone surface1.22.14.92.20.9-1.9-0.81.6-0.41.6-1.6-1.70.81.80.9-1.6
Bone volume1.62.84.42.11.8-2.0-1.61.8-1.41.8-1.8-1.61.51.61.4-0.9
Breakpoint value in progressive ratio session2.02.54.50.02.0-1.0-2.11.7-1.91.5-1.5-1.22.11.02.1-0.1
Number of licking bursts0.81.34.11.4-0.2-1.30.21.00.81.0-1.0-1.50.01.60.5-2.0
Context. condit. distance diff. score0.60.71.40.5-1.10.41.1-0.71.2-0.90.90.4-1.2-0.4-1.1-0.5
Locomotion velocity, session 10.10.10.2-0.2-0.40.20.4-0.30.4-0.40.40.2-0.3-0.2-0.3-0.0
Locomotion distance, session 11.31.72.4-0.8-1.61.31.5-1.51.3-1.41.41.1-1.5-1.1-1.50.3
Locomotion velocity, session 22.52.94.7-0.9-2.21.72.1-1.81.9-1.91.91.3-2.0-1.3-1.90.1
Locomotion distance, session 20.91.32.60.1-1.40.91.4-1.31.1-1.11.10.9-1.6-0.8-1.60.1
Locomotion velocity, session 30.80.91.5-0.7-1.21.01.2-1.11.1-0.90.90.8-1.1-0.7-1.10.1
Locomotion distance, session 31.92.13.0-0.7-1.61.51.6-1.71.2-1.61.61.4-1.6-1.3-1.70.5
Stereotopy head waving bouts, day 30.20.31.3-1.1-0.20.70.1-0.4-0.0-0.50.50.6-0.0-0.6-0.10.6
Stereotopy head waving duration, day 30.10.10.7-0.80.10.1-0.20.2-0.10.0-0.00.00.40.00.50.0
Locomotion velocity, session 70.40.40.80.8-0.80.00.8-0.40.9-0.40.40.1-0.9-0.0-0.8-0.6
Locomotion distance, session 70.81.02.00.4-1.10.71.2-1.01.1-1.11.10.8-1.4-0.7-1.4-0.1
Stereotopy head waving bouts, day 70.10.10.30.00.5-0.2-0.50.3-0.50.4-0.4-0.20.40.20.40.1
Stereotopy head waving duration, day 70.91.12.0-0.21.4-0.7-1.41.0-1.31.1-1.1-0.61.40.51.40.3
Locomotion velocity, session 81.01.34.00.7-1.70.11.6-0.52.0-0.70.7-0.2-1.40.3-1.0-1.5
Locomotion distance, session 82.94.29.91.1-2.90.93.0-1.63.2-1.61.60.6-2.9-0.3-2.5-1.5
Degree of sensitization distance0.60.61.31.10.7-1.0-0.71.0-0.40.8-0.8-0.90.60.90.7-0.7
Degree of sensitization stereotypy0.80.81.11.11.0-1.0-0.91.0-0.81.0-1.0-0.90.80.80.8-0.4
Conditioned locomotion0.10.10.3-0.50.50.1-0.50.2-0.60.2-0.20.10.4-0.20.40.6
Cocaine response after cond. corrected5.46.58.5-2.3-2.62.92.5-2.92.0-2.92.92.7-2.5-2.6-2.51.4
Cocaine response after cond. not corrected4.45.26.7-2.3-2.52.62.4-2.52.1-2.62.62.2-2.2-2.2-2.11.0
Cocaine response before conditioning0.91.11.80.60.6-1.2-0.71.3-0.21.2-1.2-1.30.91.31.2-1.0
Saline control response0.40.60.9-0.6-0.60.80.7-0.90.3-0.90.90.9-0.6-0.8-0.80.6
Bone: connectivity density1.01.63.21.80.6-1.7-0.51.3-0.01.3-1.3-1.50.71.60.8-1.6
Bone: cortical apparent density4.25.77.5-2.4-2.62.72.5-2.72.0-2.72.72.4-2.3-2.3-2.31.1
Bone: cortical area2.43.712.93.61.4-2.5-1.21.8-0.81.9-1.9-2.10.92.20.9-1.8
Bone: cortical porosity0.40.50.70.30.8-0.7-0.80.8-0.60.8-0.8-0.70.80.60.8-0.2
Bone: cortical porosity1.51.72.31.11.3-1.4-1.31.5-1.01.5-1.5-1.41.21.31.3-0.6
Bone: cortical thickness0.81.410.03.2-0.1-1.30.30.40.50.5-0.5-0.9-0.71.0-0.7-1.5
Bone: cortical thickness0.20.21.41.20.3-0.0-0.10.0-0.4-0.30.30.3-0.2-0.4-0.60.2
Bone: cortical tissue density4.25.77.4-2.5-2.62.72.5-2.72.0-2.62.62.3-2.2-2.3-2.21.1
Condit. Reinf. active minus inactive responses0.50.62.00.7-1.1-0.01.1-0.31.4-0.20.2-0.2-0.90.4-0.7-1.1
Condit. Reinf. active-inactive response ratio0.20.20.90.0-0.7-0.10.7-0.01.0-0.00.0-0.3-0.40.4-0.1-0.8
Condit. Reinf. active responses0.81.04.72.2-0.6-0.90.70.31.10.3-0.3-0.9-0.81.0-0.6-1.6
Condit. Reinf. inactive responses1.11.37.52.7-0.0-1.40.20.70.60.7-0.7-1.2-0.41.3-0.3-1.6
Incentive salience index mean0.70.92.40.7-1.30.31.4-0.71.5-0.60.60.1-1.30.1-1.2-0.9
Condit. Reinf. lever presses0.30.51.00.4-0.90.40.9-0.70.9-0.60.60.4-1.0-0.2-1.0-0.2
Condit. Reinf. active minus inactive responses1.72.23.01.11.4-1.7-1.41.7-1.11.7-1.7-1.51.61.61.6-0.9
Condit. Reinf. active-inactive response ratio0.80.91.20.81.0-1.1-1.01.1-0.91.1-1.1-0.91.01.01.0-0.5
Condit. Reinf. active responses2.73.75.01.71.9-2.2-1.82.2-1.42.1-2.1-1.92.02.12.0-1.1
Condit. Reinf. inactive responses1.21.52.11.01.2-1.4-1.21.5-1.01.4-1.4-1.21.31.21.3-0.6
Condit. Reinf. lever presses0.91.21.81.21.1-1.3-1.01.3-0.91.1-1.1-1.11.11.11.0-0.7
Condit. Reinf. lever reinforcers received1.92.73.91.61.4-2.0-1.41.9-0.91.8-1.8-1.81.51.91.6-1.3
Conditioned reinforcement - actives1.32.32.9-1.7-1.71.71.7-1.61.3-1.71.71.6-1.4-1.4-1.40.6
Conditioned reinforcement - inactives0.20.30.7-0.50.5-0.2-0.50.7-0.30.4-0.4-0.30.80.40.9-0.2
Conditioned locomotion2.73.54.8-1.6-2.21.92.2-2.01.7-2.12.11.9-1.8-1.7-1.90.6
Patch foraging indifference point 0 sec0.50.95.12.30.8-1.2-0.70.9-0.60.8-0.8-0.90.20.80.2-0.7
Patch foraging indifference point AUC0.60.91.31.01.1-1.1-1.10.9-0.91.0-1.0-0.90.80.80.9-0.3
Delay disc. indifference point, 0s delay0.30.30.50.1-0.10.60.2-0.6-0.1-0.60.60.7-0.5-0.7-0.60.7
Delay disc. indifference point, 16s delay0.70.82.9-0.51.4-0.2-1.30.5-1.70.5-0.50.21.3-0.10.90.9
Delay disc. indifference point, 2s delay1.01.13.6-1.40.51.1-0.5-0.8-1.1-0.80.81.30.3-1.4-0.11.9
Delay disc. indifference point, 24s delay1.01.12.30.41.5-0.9-1.41.0-1.51.0-1.0-0.61.40.61.10.1
Delay disc. indifference point, 4s delay0.70.72.6-0.61.20.0-1.20.2-1.60.3-0.30.41.1-0.40.81.1
Delay disc. indifference point, 8s delay0.80.93.0-0.61.4-0.2-1.40.5-1.70.5-0.50.21.3-0.11.01.0
Indifference point function ln k0.20.30.60.1-0.80.40.8-0.50.7-0.60.60.4-0.7-0.3-0.7-0.1
Indifference point function log k0.20.30.60.1-0.80.40.8-0.50.7-0.60.60.4-0.7-0.3-0.7-0.1
Patch foraging total patch changes 0 sec0.71.36.62.61.0-1.5-0.81.1-0.81.0-1.0-1.10.41.00.3-0.8
Patch foraging total patch changes 12 sec1.21.55.32.31.2-1.6-1.01.3-0.81.2-1.2-1.30.61.10.6-0.9
Patch foraging total patch changes 18 sec2.03.14.61.91.9-2.2-1.91.7-1.62.0-2.0-1.71.51.61.6-0.7
Patch foraging total patch changes 24 sec1.01.83.01.71.3-1.7-1.31.4-0.91.5-1.5-1.50.91.31.2-0.7
Patch foraging total patch changes 6 sec1.52.38.42.91.3-1.9-1.11.6-0.81.5-1.5-1.80.71.50.8-1.2
Patch foraging time to switch 0 sec0.40.84.8-2.2-0.41.10.2-0.70.2-0.60.60.80.1-0.90.11.0
Patch foraging water rate 0 sec0.40.96.22.50.6-1.1-0.50.7-0.50.5-0.5-0.80.00.8-0.1-0.8
Patch foraging water rate 12 sec0.91.96.32.51.0-1.8-0.91.3-0.61.5-1.5-1.60.51.60.6-1.2
Patch foraging water rate 18 sec0.20.30.70.4-0.40.40.4-0.60.1-0.60.60.5-0.6-0.5-0.80.2
Patch foraging water rate 24 sec0.20.20.70.50.40.2-0.3-0.3-0.7-0.30.30.6-0.1-0.6-0.40.8
Patch foraging water rate 6 sec0.10.10.70.80.3-0.2-0.3-0.1-0.5-0.10.10.1-0.1-0.1-0.30.2
Seeking ratio, delayed vs. immediate footshock1.62.04.0-0.9-2.01.22.0-1.31.9-1.41.40.8-1.6-0.9-1.4-0.1
Distance traveled before self-admin4.05.27.9-2.4-1.82.61.7-2.81.1-2.42.42.8-1.9-2.7-2.12.1
Distance traveled after self-admin2.22.75.2-2.3-1.02.11.0-1.80.4-1.81.82.1-0.9-2.1-1.21.8
Extensor digitorum longus weight1.03.98.01.72.8-1.8-2.72.0-2.62.0-2.0-1.22.11.11.80.4
Bone: elastic displacement0.30.41.4-1.10.30.6-0.3-0.4-0.7-0.30.30.70.2-0.8-0.01.2
Bone: elastic work0.60.82.1-0.6-0.11.00.2-1.0-0.4-0.90.91.3-0.5-1.3-0.91.5
Bone: endosteal estimation0.61.32.01.01.3-1.2-1.31.4-1.11.3-1.3-1.11.21.21.2-0.4
Bone: endosteal perimeter1.02.24.30.72.1-1.2-2.01.4-2.11.5-1.5-0.91.80.91.60.4
Epididymis fat weight9.934.155.77.56.4-6.9-6.16.2-5.36.3-6.3-5.55.15.44.8-2.6
Delta time in closed arm before/after self-admin1.00.91.3-0.3-1.10.91.1-0.91.0-1.11.10.8-1.1-0.9-1.10.4
Delta time in open arm before/after self-admin3.63.54.81.01.6-2.1-1.72.1-1.12.2-2.2-2.11.92.12.2-1.4
Diff in mean of infusions in LGA sessions0.70.91.60.31.3-0.7-1.31.1-1.10.9-0.9-0.81.20.61.20.0
Delay discount exponential model param1.11.24.40.6-1.70.21.6-0.52.1-0.50.5-0.3-1.50.3-1.1-1.3
Extinction: sum of active levers before priming1.61.84.50.11.8-0.7-1.81.2-2.01.2-1.2-0.72.10.71.70.1
Active lever presses in extinction session 60.60.61.50.21.0-0.4-1.00.6-1.20.6-0.6-0.41.20.30.90.1
Bone: final force0.91.47.52.70.5-1.5-0.40.9-0.11.0-1.0-1.20.11.3-0.0-1.3
Bone: final moment0.91.47.02.70.6-1.5-0.51.1-0.21.1-1.1-1.20.21.40.1-1.3
Food consumed during 24 hour testing period0.30.41.10.1-0.90.20.9-0.41.1-0.40.4-0.0-0.80.1-0.6-0.6
Glucose1.62.64.91.12.2-1.4-2.11.7-2.11.7-1.7-1.11.80.91.60.3
Heart weight2.13.312.33.51.2-2.4-1.11.7-0.71.8-1.8-2.00.82.10.7-1.7
Delay discount hyperbolic model param1.21.34.60.7-1.70.11.6-0.42.1-0.40.4-0.4-1.50.4-1.1-1.4
Intermittent access intake day 1-15 change0.30.62.3-1.50.30.9-0.4-0.7-0.6-0.50.50.80.1-1.10.11.3
Intermittent access intake escalation0.20.41.8-1.30.30.8-0.4-0.4-0.4-0.40.40.60.1-0.80.20.9
Intermittent access intake escalation 20.20.30.7-0.8-0.20.80.1-0.50.1-0.60.60.6-0.2-0.8-0.20.5
Intermitt. access day 1 inactive lever presses0.93.55.70.61.9-1.9-2.02.3-1.42.1-2.1-1.92.11.82.4-1.0
Intermitt. access day 15 inactive lever presses0.40.81.20.61.1-0.9-1.10.9-0.91.0-1.0-0.71.00.71.0-0.2
Intermitt. access escalation Index0.00.10.4-0.6-0.10.10.00.20.1-0.10.1-0.20.3-0.10.30.0
Intermittent access day 1 total infusions0.10.10.5-0.70.00.4-0.0-0.3-0.1-0.20.20.50.0-0.4-0.00.7
Intermittent access day 15 total infusions0.40.62.6-1.60.30.8-0.5-0.4-0.6-0.40.40.70.3-0.90.31.3
Intermittent access terminal intake (last 3 days)0.30.41.4-1.20.60.5-0.7-0.2-0.7-0.10.10.50.5-0.70.51.1
Intermittent access total infusions0.10.20.8-0.90.20.4-0.2-0.2-0.3-0.20.20.40.1-0.50.20.8
Intermittent access day 1 locomotion1.31.74.3-1.8-0.21.60.2-1.2-0.4-1.31.31.8-0.3-1.7-0.62.1
Intermittent access day 15 total locomotion0.50.92.2-0.41.4-0.1-1.40.6-1.50.6-0.6-0.11.2-0.11.10.9
Intermittent access total locomotion1.11.33.0-1.3-0.21.50.2-1.1-0.3-1.21.21.6-0.3-1.6-0.61.7
Intermittent access standard deviation0.61.33.5-0.81.6-0.4-1.70.6-1.90.8-0.8-0.11.60.11.50.7
Left kidney weight0.31.615.74.00.8-1.4-0.50.6-0.70.4-0.4-0.5-0.40.5-0.7-0.7
Right kidney weight0.31.110.93.31.0-0.9-0.70.3-1.00.0-0.00.0-0.2-0.0-0.70.0
Cocaine induced anxiety2.13.05.3-0.7-2.21.52.2-1.72.3-1.81.81.0-2.3-1.2-2.00.1
Post-drug Anxiety0.60.61.81.3-0.8-0.50.9-0.01.20.0-0.0-0.7-1.00.5-0.7-1.1
Baseline Anxiety3.74.36.31.91.9-2.5-1.92.1-1.52.4-2.4-2.12.02.22.1-1.4
Tail length0.31.01.50.41.2-1.0-1.21.0-1.01.2-1.2-1.01.20.81.2-0.2
Length with tail0.94.06.02.41.9-2.5-1.92.2-1.42.3-2.3-2.11.62.01.7-1.2
Length without tail2.47.711.83.42.6-3.4-2.53.1-1.83.1-3.1-3.02.32.92.4-1.8
Times rat made contact with spout0.00.00.10.3-0.0-0.10.00.00.00.1-0.1-0.1-0.10.1-0.1-0.1
Lifetime Intake0.10.20.6-0.8-0.20.50.2-0.40.2-0.30.30.5-0.2-0.5-0.20.5
Liver weight, left2.23.79.23.02.4-2.2-2.22.0-2.11.9-1.9-1.61.51.41.3-0.5
Liver weight, right0.20.41.91.40.8-0.2-0.70.2-1.0-0.00.00.10.1-0.4-0.10.5
Locomotor activity0.10.10.3-0.50.00.4-0.0-0.2-0.2-0.30.30.40.1-0.4-0.10.4
Locomotor testing distance0.81.52.3-1.2-0.91.50.9-1.40.5-1.51.51.5-1.0-1.5-1.11.1
Locomotor testing rearing0.51.13.0-1.60.11.2-0.1-0.9-0.6-1.01.01.4-0.1-1.5-0.31.7
Locomotion in novel chamber1.51.93.2-0.5-1.51.21.6-1.51.4-1.61.61.2-1.8-1.3-1.70.6
Locomotion in novel chamber post-restriction1.32.23.2-0.6-1.41.41.5-1.71.1-1.71.71.6-1.7-1.5-1.80.9
Fecal boli incidents, locomotor time 10.00.10.20.5-0.1-0.30.10.20.30.2-0.2-0.4-0.10.3-0.0-0.4
Change in fecal boli incidents, locomotor task0.30.31.51.2-0.2-0.50.30.10.50.2-0.2-0.4-0.60.4-0.4-0.5
Time >=10cm from walls, locomotor time 10.20.20.60.1-0.7-0.10.6-0.10.8-0.10.1-0.2-0.40.3-0.3-0.7
Bouts of movement, locomotor time 11.41.62.9-0.11.6-1.1-1.71.3-1.61.3-1.3-0.81.60.71.60.2
Total resting periods, locomotor time 10.70.81.6-0.21.2-0.8-1.30.9-1.20.8-0.8-0.51.10.41.10.3
Rest time, locomotor task time 10.50.71.50.4-1.00.51.0-0.80.9-0.90.90.6-1.2-0.5-1.2-0.0
Distance moved, locomotor task time 10.20.20.7-0.60.60.2-0.60.2-0.80.1-0.10.20.7-0.30.50.7
Vertical activity count, locomotor time 10.10.20.5-0.40.20.5-0.2-0.4-0.4-0.40.40.60.1-0.6-0.10.7
Time >=10cm from walls, locomotor time 20.40.62.51.6-0.7-0.50.8-0.11.1-0.10.1-0.4-1.00.4-0.8-1.0
Bouts of movement, locomotor time 20.40.64.0-2.00.40.6-0.5-0.1-0.7-0.20.20.70.6-0.70.61.2
Total resting periods, locomotor time 20.50.84.5-2.10.60.7-0.7-0.1-1.0-0.20.20.80.8-0.80.71.4
Rest time, locomotor task time 20.30.41.1-1.00.10.8-0.1-0.5-0.4-0.50.50.80.0-0.8-0.11.0
Distance moved, locomotor task time 20.20.20.60.8-0.6-0.10.6-0.10.7-0.10.1-0.2-0.60.2-0.6-0.7
Vertical activity count, locomotor time 20.20.31.21.1-0.5-0.30.6-0.00.7-0.10.1-0.3-0.70.2-0.5-0.7
Light reinforcement 10.30.71.7-0.0-0.90.61.0-1.10.9-0.70.70.6-1.3-0.6-1.20.2
Light reinforcement 20.81.22.2-0.4-1.51.01.5-1.21.4-1.01.00.7-1.4-0.6-1.4-0.1
Bone: marrow area0.61.42.01.11.3-1.2-1.21.4-1.11.3-1.3-1.11.21.21.1-0.5
Bone: maximum diameter2.95.36.72.22.6-2.5-2.52.5-2.12.6-2.6-2.22.32.22.3-0.9
Bone: maximum force0.71.27.52.70.1-1.30.00.80.30.7-0.7-1.1-0.31.2-0.3-1.5
Bone: maximum moment0.71.37.12.70.2-1.4-0.10.90.20.8-0.8-1.2-0.21.3-0.1-1.5
Mean time between licks in bursts0.51.22.10.40.4-1.2-0.51.20.11.2-1.2-1.50.91.51.2-1.4
Mean num. licks in bursts1.01.64.5-1.40.11.40.0-1.2-0.7-1.21.21.7-0.3-1.8-0.72.1
Cd content in liver4.55.08.1-0.6-2.82.02.8-2.42.5-2.42.41.6-2.8-1.6-2.7-0.1
Co content in liver1.72.03.60.3-1.71.21.8-1.61.4-1.61.61.0-1.8-1.0-1.9-0.1
Cu content in liver0.40.50.8-0.8-0.70.80.7-0.90.5-0.80.80.8-0.6-0.8-0.60.3
Fe content in liver2.32.84.72.21.0-2.1-1.01.9-0.31.9-1.9-2.11.02.11.3-1.8
K content in liver0.40.41.5-1.20.50.4-0.5-0.1-0.8-0.00.00.40.7-0.50.60.8
Mg content in liver1.21.24.4-2.10.71.0-0.8-0.4-1.3-0.40.41.10.7-1.20.51.9
Mn content in liver0.20.20.8-0.40.60.3-0.5-0.1-0.9-0.10.10.30.4-0.40.20.8
Na content in liver0.91.02.7-1.31.20.3-1.20.2-1.60.2-0.20.51.3-0.60.91.4
Rb content in liver0.40.41.1-0.60.9-0.2-0.90.5-1.00.5-0.5-0.11.00.00.90.4
Se content in liver0.10.20.40.6-0.5-0.20.50.00.60.1-0.1-0.5-0.40.3-0.2-0.7
Sr content in liver2.21.93.1-1.5-1.21.81.2-1.60.8-1.61.61.4-1.3-1.6-1.21.1
Zn content in liver2.52.75.7-2.4-0.82.10.7-1.80.1-1.71.72.1-0.9-2.2-1.02.0
Bone: minimum diameter1.42.56.12.51.6-2.0-1.41.6-1.21.7-1.7-1.61.11.71.1-1.0
Time in familiar zone, hab. session 10.50.51.8-0.40.70.5-0.7-0.3-1.1-0.40.40.90.3-1.0-0.11.4
Time in novel zone, hab. session 11.01.02.40.70.0-1.2-0.11.10.51.1-1.1-1.40.51.50.8-1.5
Total zone transitions, hab. session 10.10.10.40.30.10.2-0.0-0.4-0.4-0.20.20.5-0.3-0.4-0.40.6
Total locomotion distance, hab. session 10.50.72.61.4-0.5-0.90.50.50.90.4-0.4-0.9-0.41.0-0.1-1.6
Locomotion velocity, hab. session 10.40.62.11.2-0.6-0.70.70.31.00.3-0.3-0.8-0.50.9-0.3-1.4
Time in familiar zone, hab. session 21.61.72.50.71.1-1.5-1.21.5-0.71.6-1.6-1.51.31.41.4-0.8
Time in novel zone, hab. session 21.21.21.7-0.6-1.01.21.0-1.30.6-1.31.31.3-1.1-1.2-1.20.7
Total zone transitions, hab. session 20.20.20.9-0.50.20.5-0.1-0.5-0.5-0.30.30.7-0.0-0.7-0.21.0
Total locomotion distance, hab. session 20.00.10.50.70.0-0.2-0.00.20.00.0-0.0-0.1-0.10.1-0.1-0.3
Locomotion velocity, hab. session 20.00.00.20.50.2-0.1-0.10.1-0.2-0.00.00.00.0-0.0-0.0-0.0
Novel to familiar place preference ratio0.91.02.91.5-0.2-1.20.20.80.70.9-0.9-1.3-0.01.40.3-1.7
Novelty place preference0.70.72.11.2-0.1-1.10.10.80.60.8-0.8-1.10.11.20.3-1.5
Time in novel zone, NPP test1.41.53.01.60.3-1.6-0.31.30.31.2-1.2-1.60.41.60.7-1.7
Total zone transitions, NPP test0.00.00.10.1-0.10.20.1-0.3-0.1-0.10.10.2-0.2-0.2-0.30.3
Total locomotion distance, NPP test0.40.61.41.1-0.9-0.21.0-0.21.2-0.30.3-0.2-1.00.4-0.8-1.0
Locomotion velocity, NPP test0.81.12.40.7-1.40.41.5-0.81.6-0.80.80.2-1.5-0.1-1.3-0.8
Intraocular pressure1.72.43.51.81.2-1.9-1.21.8-0.91.7-1.7-1.91.31.71.4-1.3
Delta distance traveled before/after self-admin0.40.41.3-0.60.90.0-0.90.4-1.10.1-0.10.10.9-0.20.70.7
Delta ambulatory time before/after self-admin0.50.61.4-0.11.0-0.4-1.00.8-1.20.5-0.5-0.31.10.21.00.3
Parametrial fat weight9.121.529.25.45.4-5.2-5.14.9-4.65.1-5.1-4.24.24.14.0-1.4
Pavlov. Cond. lever latency0.30.40.9-0.30.6-0.5-0.60.7-0.40.6-0.6-0.60.80.51.0-0.3
Pavlov. Cond. magazine entry latency0.00.00.00.10.10.0-0.1-0.1-0.20.1-0.10.00.0-0.0-0.10.2
Pavlov. Cond. change in total contacts0.10.10.40.20.50.1-0.4-0.0-0.6-0.10.10.30.2-0.3-0.00.6
Pavlov. Cond. index score0.00.00.20.30.30.1-0.2-0.1-0.40.0-0.00.20.1-0.2-0.10.4
Pavlov. Cond. latency score0.00.00.10.20.10.2-0.0-0.2-0.2-0.10.10.2-0.1-0.2-0.30.4
Pavlov. Cond. lever contacts0.00.10.20.20.20.2-0.1-0.2-0.3-0.10.10.3-0.0-0.3-0.20.5
Pavlov. Cond. magazine entry number0.10.10.40.1-0.5-0.10.5-0.00.6-0.20.2-0.2-0.40.2-0.2-0.6
Pavlov. Cond. intertrial magazine entries0.60.73.51.9-0.7-0.30.8-0.21.0-0.30.3-0.2-1.10.2-1.0-1.0
Pavlov. Cond. lever-magazine prob. diff.0.00.10.20.40.30.0-0.3-0.0-0.40.1-0.10.10.1-0.0-0.10.3
Pavlov. Cond. response bias0.10.10.3-0.20.10.4-0.0-0.3-0.2-0.20.20.4-0.1-0.4-0.30.6
Pavlov. Cond. lever latency1.31.82.7-1.1-1.11.61.1-1.60.7-1.51.51.5-1.3-1.5-1.41.2
Pavlov. Cond. magazine entry latency1.01.22.3-0.11.3-0.9-1.41.3-1.21.2-1.2-0.81.50.71.5-0.1
Pavlov. Cond. change in total contacts0.71.11.80.51.0-1.2-1.01.4-0.81.2-1.2-1.11.31.11.3-0.7
Pavlov. Cond. index score1.31.72.60.71.3-1.4-1.31.6-1.11.4-1.4-1.21.51.31.5-0.7
Pavlov. Cond. latency score1.11.52.20.61.2-1.3-1.21.5-1.01.3-1.3-1.21.41.21.4-0.7
Pavlov. Cond. lever contacts0.71.01.51.00.8-1.2-0.71.2-0.51.0-1.0-1.10.91.10.9-1.0
Pavlov. Cond. magazine entry number0.70.91.6-0.1-1.20.81.2-1.11.1-1.01.00.7-1.3-0.7-1.20.1
Pavlov. Cond. intertrial magazine entries0.10.11.01.00.2-0.4-0.20.1-0.20.2-0.2-0.2-0.10.2-0.2-0.1
Pavlov. Cond. lever-magazine prob. diff.1.01.32.00.51.2-1.2-1.21.4-1.01.2-1.2-1.01.41.11.4-0.5
Pavlov. Cond. response bias1.41.93.11.11.2-1.6-1.21.7-0.81.5-1.5-1.51.41.61.5-1.2
Time in closed arm before self-admin0.20.20.6-0.50.40.5-0.3-0.3-0.8-0.40.40.60.4-0.6-0.00.8
Time in closed arm after self-admin1.71.83.5-1.5-0.81.70.8-1.4-0.0-1.71.71.9-0.5-1.7-1.11.3
Time in open arm before self-admin0.70.83.0-0.2-1.30.31.3-0.51.7-0.50.50.1-1.3-0.1-0.8-0.5
Time in open arm after self-admin1.41.63.00.70.7-1.5-0.81.40.01.6-1.6-1.70.81.71.4-1.2
Bone: periosteal estimation1.32.78.02.81.5-2.0-1.31.7-1.01.7-1.7-1.71.01.80.9-1.2
Bone: periosteal perimeter2.34.06.52.02.6-2.1-2.42.0-2.42.1-2.1-1.62.11.61.8-0.3
Bone: post-yield work1.31.96.02.5-0.3-1.50.41.01.01.0-1.0-1.7-0.41.80.0-2.3
Progressive ratio test 1 active lever presses0.70.93.6-1.9-0.11.20.1-0.7-0.3-0.80.81.20.1-1.1-0.11.2
Progressive ratio test 1 breakpoint0.70.83.4-1.9-0.21.10.1-0.7-0.3-0.80.81.20.1-1.1-0.11.2
Progressive ratio test 1 inactive lever presses0.20.20.6-0.20.7-0.2-0.70.7-0.60.3-0.3-0.10.80.20.70.1
Progressive ratio test 2 active lever presses0.40.41.1-0.90.70.4-0.8-0.1-1.0-0.10.10.50.6-0.60.51.1
Progressive ratio test 2 breakpoint0.40.41.0-0.90.80.4-0.8-0.0-1.0-0.00.00.40.7-0.50.51.0
Progressive ratio test 2 inactive lever presses0.10.20.60.40.0-0.4-0.00.70.30.4-0.4-0.50.20.60.4-0.8
Incentive Sensitization - Responses0.50.72.1-0.31.4-0.2-1.40.6-1.50.5-0.5-0.11.1-0.11.00.7
Incentive Sensitization - Breakpoint0.60.82.2-0.21.4-0.3-1.40.7-1.50.6-0.6-0.21.10.11.10.6
Sum of active levers in priming session hrs 5-61.51.42.7-0.31.5-0.7-1.61.1-1.51.1-1.1-0.81.70.61.60.2
Progressive ratio0.30.51.6-0.8-1.20.41.2-0.41.3-0.40.40.1-0.60.0-0.4-0.7
Food seeking constrained by brief footshock0.00.00.2-0.1-0.50.10.4-0.20.3-0.10.10.0-0.10.1-0.1-0.1
Seeking ratio, punishment vs. effort0.30.52.0-0.10.70.4-0.7-0.3-1.1-0.30.30.70.3-0.8-0.01.4
Retroperitoneal fat weight9.741.482.89.17.1-7.6-6.76.8-5.96.8-6.8-6.05.25.94.9-2.8
Reaction time number correct0.51.02.5-1.01.4-0.2-1.40.6-1.60.6-0.60.11.50.11.30.8
Reaction time mean minus median0.51.23.5-0.91.5-0.2-1.60.4-1.90.6-0.60.31.5-0.21.21.1
Reaction time mean minus median AUC0.92.25.6-2.41.50.8-1.6-0.4-2.3-0.20.21.41.5-1.30.92.4
Reaction time num false alarms0.30.51.10.6-0.80.30.9-0.70.7-0.70.70.5-0.9-0.4-1.0-0.3
Reaction time num false alarms AUC0.40.61.20.2-0.80.70.9-0.90.5-0.90.90.8-0.8-0.7-1.10.1
Reaction time trials correct on left0.51.02.5-1.01.4-0.2-1.40.6-1.60.6-0.60.11.50.11.30.8
Reaction time trials on left0.61.22.8-1.11.5-0.3-1.50.7-1.70.7-0.70.01.60.11.40.9
Reaction time mean1.32.16.5-2.61.30.9-1.4-0.3-2.0-0.20.21.21.5-1.21.02.3
Reaction time mean AUC1.62.58.3-2.91.41.1-1.5-0.4-2.2-0.30.31.41.5-1.51.02.6
Median of all reaction times1.72.38.6-2.91.01.3-1.1-0.6-1.8-0.60.61.61.2-1.60.72.6
Reaction time omissions2.03.06.4-0.62.4-0.9-2.51.5-2.51.5-1.5-0.62.40.62.20.9
Reaction time false alarm rate0.81.12.31.1-1.40.41.5-0.81.3-0.90.90.4-1.5-0.4-1.5-0.7
Reaction time premature initiation rate0.30.40.80.2-0.50.50.6-0.80.3-0.80.80.8-0.6-0.6-0.90.2
Reaction time premature initiations0.10.20.6-0.40.30.3-0.2-0.4-0.6-0.40.40.70.3-0.5-0.10.7
Std. dev. reaction times1.01.95.9-1.02.0-0.3-2.00.6-2.40.8-0.80.22.0-0.21.51.4
Reaction time trials completed0.61.22.8-1.11.5-0.3-1.50.7-1.70.7-0.70.01.60.11.40.9
Reaction time trials AUC0.61.12.7-0.91.4-0.3-1.50.7-1.60.7-0.70.01.60.11.30.8
Run reversals in cocaine runway, females0.20.20.50.10.5-0.3-0.50.6-0.60.1-0.1-0.10.70.10.6-0.1
Run reversals in cocaine runway, males0.60.61.1-0.5-0.61.10.6-1.10.2-0.70.70.9-0.6-0.8-0.91.0
Latency to leave start box in cocaine runway0.91.04.3-2.10.90.4-1.00.2-1.40.0-0.00.61.4-0.51.11.0
Latency to leave start box in cocaine runway, F0.50.61.4-1.00.9-0.0-1.00.5-1.10.3-0.30.01.2-0.01.00.6
Latency to leave start box in cocaine runway, M0.70.63.0-1.70.30.7-0.4-0.4-0.8-0.50.50.90.6-0.80.31.0
Std. dev. time between licks in bursts0.60.83.20.8-1.0-0.61.00.31.50.2-0.2-0.9-0.60.9-0.2-1.8
Total sessions with >9 infusions0.40.50.8-0.6-0.90.80.9-0.70.7-0.80.80.8-0.6-0.5-0.80.0
Short access day 1 total inactive lever presses0.50.63.10.6-0.5-0.50.60.80.90.4-0.4-0.80.11.10.1-1.8
Short access day 10 total inactive lever presses0.10.20.70.50.7-0.3-0.60.6-0.80.1-0.1-0.00.70.00.3-0.0
Short access day 1 total infusions0.20.20.7-0.5-0.40.80.4-0.40.0-0.60.60.7-0.0-0.5-0.40.3
Short access day 10 total infusions1.51.93.1-1.8-1.31.71.3-1.50.8-1.51.51.6-0.9-1.4-1.10.8
Short access total infusions0.81.01.4-1.1-1.21.21.2-1.10.9-1.01.01.0-0.8-0.7-1.00.3
Short access day 1 locomotion0.40.52.1-1.40.30.8-0.3-0.2-0.8-0.40.40.90.7-0.60.30.6
Short access day 10 total locomotion0.71.22.7-1.6-0.31.60.3-1.0-0.6-1.21.21.70.1-1.4-0.61.4
Short access total locomotion2.12.54.5-2.0-1.22.11.2-1.70.5-1.81.82.1-0.8-1.8-1.31.3
One hour access (0.3 mA shock)0.91.02.3-0.21.2-0.7-1.31.1-0.91.1-1.1-0.81.20.71.5-0.0
Compulsive drug intake1.01.21.90.91.2-1.1-1.21.4-1.01.1-1.1-1.01.21.01.1-0.4
One hour access (shock baseline)0.20.21.3-1.1-0.30.60.2-0.50.4-0.30.30.4-0.3-0.5-0.00.5
Social response proportion0.50.61.30.1-0.00.90.1-0.5-0.4-0.90.91.1-0.4-1.1-0.81.1
Social responses0.60.82.51.61.1-1.0-1.00.9-0.90.9-0.9-0.80.60.70.5-0.1
Social time1.01.45.0-1.70.91.0-0.9-0.4-1.4-0.60.61.30.6-1.50.32.2
Soleus weight1.54.414.5-1.52.90.7-2.80.2-3.80.1-0.11.52.0-1.81.23.6
Bone: stiffness0.81.36.42.5-0.1-1.30.20.70.60.8-0.8-1.2-0.31.4-0.2-1.8
Tibialis anterior weight1.03.27.3-0.42.7-1.0-2.71.6-2.71.5-1.5-0.52.40.32.11.3
Time to tail flick, vehicle, before self-admin0.60.61.71.3-0.7-0.70.70.21.10.2-0.2-0.7-0.70.8-0.5-1.2
Time to tail flick, vehicle, after self-admin0.10.10.91.00.2-0.3-0.20.3-0.00.3-0.3-0.4-0.10.20.0-0.1
Time to tail flick, test, before self-admin2.93.05.1-1.8-1.32.21.3-1.90.5-2.12.12.3-1.1-2.1-1.51.5
Time to tail flick, test, after self-admin0.60.61.40.50.2-0.8-0.30.90.20.9-0.9-1.20.51.10.7-1.0
Delta time to tail flick, vehicle, before/after SA1.11.12.50.01.5-0.5-1.60.9-1.50.9-0.9-0.71.30.41.30.4
Delta time to tail flick, test, before/after SA1.41.43.21.40.5-1.5-0.51.30.31.4-1.4-1.80.41.60.8-1.4
Tibia length0.00.10.80.9-0.2-0.10.3-0.10.3-0.10.1-0.0-0.40.1-0.5-0.2
Ambulatory time before self-admin2.33.45.2-1.8-1.72.11.6-2.31.1-2.02.02.2-1.7-2.0-1.91.4
Ambulatory time after self-admin1.41.63.2-1.8-0.51.70.5-1.3-0.0-1.41.41.7-0.5-1.7-0.71.6
Bone: tissue strength0.10.10.10.0-0.1-0.20.00.20.20.2-0.2-0.40.10.30.2-0.4
Total heroin consumption2.63.15.01.02.2-1.4-2.21.7-2.21.8-1.8-1.42.21.32.0-0.3
Bone: trabecular number2.23.66.62.61.4-2.5-1.32.2-0.62.0-2.0-2.21.32.21.5-1.9
Bone: trabecular spacing0.30.41.8-1.3-0.70.70.6-0.70.6-0.40.40.4-0.3-0.3-0.20.1
Bone: trabecular thickness2.42.95.22.32.1-2.0-1.92.0-1.71.7-1.7-1.51.51.41.4-0.6
Bone: trabecular tissue density1.42.15.8-2.4-0.71.80.6-1.60.1-1.51.51.7-0.6-1.9-0.71.8
Water consumed over 24 hours0.20.30.5-0.6-0.50.70.5-0.60.3-0.70.70.7-0.5-0.6-0.50.4
Number of responses in last shaping day0.30.30.7-0.7-0.30.70.3-0.50.1-0.70.70.7-0.4-0.9-0.40.6