Hub : Genes

Hspa12a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Hspa12a 0.07 0.06 6.8e-06 0.02 0.03 0.03 0.03 1.6e-03 4.6e-05 2.3e-05 9.9e-05
2 pVTA mRNA stability Hspa12a 0.19 0.09 5.6e-11 0.09 0.14 0.12 0.12 1.1e-07 5.4e-11 1.1e-09 6.7e-10
3 Adipose gene expression Hspa12a 0.43 0.14 0.0e+00 0.26 0.27 0.28 0.28 9.4e-29 5.4e-30 2.4e-31 1.5e-30
4 OFC gene expression Hspa12a 0.26 0.14 1.6e-04 0.04 0.16 0.12 0.11 5.2e-02 1.2e-04 9.3e-04 1.5e-03
5 NAcc mRNA stability Hspa12a 0.07 0.06 5.1e-06 0.04 0.04 0.04 0.04 4.0e-07 4.0e-06 5.1e-07 8.0e-07
6 Brain gene expression Hspa12a 0.11 0.06 1.3e-07 0.06 0.09 0.09 0.08 1.1e-06 1.5e-08 1.5e-08 4.0e-08
7 OFC mRNA stability Hspa12a 0.17 0.11 8.0e-03 0.07 0.05 0.01 0.04 8.3e-03 2.7e-02 1.4e-01 4.2e-02
8 Adipose alternative TSS XM_063288270.1 0.07 0.06 2.3e-03 0.02 0 0.01 0.01 5.6e-03 8.8e-02 1.2e-02 4.1e-02
9 Adipose mRNA stability Hspa12a 0.27 0.12 0.0e+00 0.13 0.16 0.17 0.17 4.9e-14 4.8e-17 2.3e-18 1.3e-18
10 pVTA intron excision ratio chr1_268068664_268071439 0.13 0.13 8.6e-03 0 0.01 0.01 0 1.7e-01 6.1e-02 8.3e-02 1.1e-01
11 IC mRNA stability Hspa12a 0.11 0.07 2.1e-04 0.08 0.08 0.05 0.09 2.9e-04 4.4e-04 3.3e-03 1.6e-04
12 Brain mRNA stability Hspa12a 0.13 0.09 3.7e-06 0.03 0.06 0.06 0.05 8.6e-04 1.6e-06 4.3e-06 9.8e-06
13 Liver gene expression Hspa12a 0.04 0.03 1.9e-05 0.04 0.04 0.03 0.04 6.8e-05 8.4e-05 8.6e-04 8.4e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density1.83.36.0-2.41.42.4-1.3-2.10.8-1.91.9-2.01.32.11.41.7
Area under the delay curve0.71.13.90.41.60.2-1.5-0.52.0-0.50.50.21.4-0.21.0-1.1
BMI with tail3.813.334.0-5.84.84.0-4.3-3.64.3-3.43.4-2.62.92.52.30.5
BMI without tail1.26.622.6-4.83.22.9-2.9-2.42.8-2.32.3-1.81.71.81.30.7
Body weight5.122.347.0-6.95.65.5-5.2-4.94.7-4.84.8-4.13.93.93.51.6
Weight adjusted by age0.10.42.6-1.60.90.6-0.7-0.41.0-0.20.2-0.10.40.10.0-0.1
Bone surface1.12.14.9-2.20.91.9-0.8-1.60.4-1.61.6-1.70.81.80.91.6
Bone volume1.42.84.4-2.11.82.0-1.6-1.81.4-1.81.8-1.61.51.61.40.9
Breakpoint value in progressive ratio session1.42.54.5-0.02.01.0-2.1-1.71.9-1.51.5-1.22.11.02.10.1
Number of licking bursts0.41.34.1-1.4-0.21.30.2-1.0-0.8-1.01.0-1.50.01.70.52.0
Context. condit. distance diff. score0.60.71.4-0.5-1.1-0.41.10.7-1.20.9-0.90.4-1.2-0.4-1.10.5
Locomotion velocity, session 10.10.10.20.2-0.4-0.20.40.3-0.40.4-0.40.2-0.3-0.2-0.30.0
Locomotion distance, session 11.31.72.40.8-1.6-1.31.51.5-1.31.4-1.41.1-1.5-1.1-1.5-0.3
Locomotion velocity, session 22.42.94.70.9-2.2-1.72.11.8-1.91.9-1.91.3-2.0-1.3-1.9-0.1
Locomotion distance, session 20.91.32.6-0.1-1.4-0.91.41.3-1.11.1-1.10.9-1.6-0.8-1.6-0.1
Locomotion velocity, session 30.80.91.50.7-1.2-1.01.21.1-1.10.9-0.90.8-1.1-0.7-1.1-0.1
Locomotion distance, session 31.82.13.00.7-1.6-1.51.61.7-1.21.6-1.61.4-1.6-1.3-1.7-0.5
Stereotopy head waving bouts, day 30.20.31.31.1-0.2-0.70.10.40.00.5-0.50.6-0.0-0.6-0.1-0.6
Stereotopy head waving duration, day 30.10.10.70.80.1-0.1-0.2-0.20.1-0.00.00.00.40.00.5-0.0
Locomotion velocity, session 70.40.40.8-0.8-0.8-0.00.80.4-0.90.4-0.40.1-0.9-0.0-0.80.6
Locomotion distance, session 70.81.02.0-0.4-1.1-0.71.21.0-1.11.1-1.10.8-1.4-0.7-1.40.1
Stereotopy head waving bouts, day 70.10.10.3-0.00.50.2-0.5-0.30.5-0.40.4-0.20.40.20.4-0.1
Stereotopy head waving duration, day 70.91.12.00.21.40.7-1.4-1.01.3-1.11.1-0.61.40.51.4-0.3
Locomotion velocity, session 81.01.34.0-0.7-1.7-0.11.60.5-2.00.7-0.7-0.2-1.40.3-1.01.5
Locomotion distance, session 82.94.29.9-1.1-2.9-0.93.01.6-3.21.6-1.60.6-2.9-0.3-2.51.5
Degree of sensitization distance0.60.61.3-1.10.71.0-0.7-1.00.4-0.80.8-0.90.60.90.70.7
Degree of sensitization stereotypy0.70.81.1-1.11.01.0-0.9-1.00.8-1.01.0-0.90.80.80.80.4
Conditioned locomotion0.10.10.30.50.5-0.1-0.5-0.20.6-0.20.20.10.4-0.20.4-0.6
Cocaine response after cond. corrected4.36.58.52.3-2.6-2.92.52.9-2.02.9-2.92.7-2.5-2.6-2.5-1.4
Cocaine response after cond. not corrected3.65.26.72.3-2.5-2.62.42.5-2.12.6-2.62.2-2.2-2.2-2.1-1.0
Cocaine response before conditioning0.91.11.8-0.60.61.2-0.7-1.30.2-1.21.2-1.30.91.31.21.0
Saline control response0.40.60.90.6-0.6-0.80.70.9-0.30.9-0.90.9-0.6-0.8-0.8-0.6
Bone: connectivity density1.01.63.2-1.80.61.7-0.5-1.30.0-1.31.3-1.50.71.60.81.6
Bone: cortical apparent density3.65.77.52.4-2.6-2.72.52.7-2.02.7-2.72.4-2.3-2.3-2.3-1.1
Bone: cortical area2.33.712.9-3.61.42.5-1.2-1.80.8-1.91.9-2.10.92.20.91.8
Bone: cortical porosity0.40.50.7-0.30.80.7-0.8-0.80.6-0.80.8-0.70.80.60.80.2
Bone: cortical porosity1.51.72.3-1.11.31.4-1.3-1.51.0-1.51.5-1.41.21.31.30.6
Bone: cortical thickness0.81.410.0-3.2-0.11.30.3-0.4-0.5-0.50.5-0.9-0.71.0-0.71.5
Bone: cortical thickness0.20.21.4-1.20.30.0-0.1-0.00.40.3-0.30.3-0.2-0.4-0.6-0.2
Bone: cortical tissue density3.65.77.42.5-2.6-2.72.52.7-2.02.6-2.62.3-2.2-2.3-2.2-1.1
Condit. Reinf. active minus inactive responses0.50.62.0-0.7-1.10.01.10.3-1.40.2-0.2-0.2-0.90.4-0.71.1
Condit. Reinf. active-inactive response ratio0.20.20.9-0.0-0.70.10.70.0-1.00.0-0.0-0.3-0.40.4-0.10.8
Condit. Reinf. active responses0.81.04.7-2.2-0.60.90.7-0.3-1.1-0.30.3-0.9-0.81.0-0.61.6
Condit. Reinf. inactive responses1.01.37.4-2.7-0.01.40.2-0.7-0.6-0.70.7-1.2-0.41.3-0.31.6
Incentive salience index mean0.70.92.4-0.7-1.3-0.31.40.7-1.50.6-0.60.1-1.30.1-1.20.9
Condit. Reinf. lever presses0.30.51.0-0.4-0.9-0.40.90.7-0.90.6-0.60.4-1.0-0.2-1.00.2
Condit. Reinf. active minus inactive responses1.42.23.0-1.11.41.7-1.4-1.71.1-1.71.7-1.51.61.61.60.9
Condit. Reinf. active-inactive response ratio0.60.91.2-0.81.01.1-1.0-1.10.9-1.11.1-0.91.01.01.00.5
Condit. Reinf. active responses2.63.75.0-1.71.92.2-1.8-2.21.4-2.12.1-1.92.02.12.01.1
Condit. Reinf. inactive responses1.01.52.1-1.01.21.4-1.2-1.51.0-1.41.4-1.21.31.21.30.6
Condit. Reinf. lever presses0.81.21.8-1.21.11.3-1.0-1.30.9-1.11.1-1.11.11.11.00.7
Condit. Reinf. lever reinforcers received1.92.73.9-1.61.42.0-1.4-1.90.9-1.81.8-1.81.51.91.61.3
Conditioned reinforcement - actives0.62.32.91.7-1.7-1.71.71.6-1.31.7-1.71.6-1.4-1.4-1.4-0.6
Conditioned reinforcement - inactives0.10.30.70.50.50.2-0.5-0.70.3-0.40.4-0.30.80.40.90.2
Conditioned locomotion2.33.54.81.6-2.2-1.92.22.0-1.72.1-2.11.9-1.8-1.7-1.9-0.6
Patch foraging indifference point 0 sec0.30.95.1-2.30.81.2-0.7-0.90.6-0.80.8-0.90.20.80.20.7
Patch foraging indifference point AUC0.40.91.3-1.01.11.1-1.1-0.90.9-1.01.0-0.90.80.80.90.3
Delay disc. indifference point, 0s delay0.20.30.5-0.1-0.1-0.60.20.60.10.6-0.60.7-0.5-0.7-0.6-0.7
Delay disc. indifference point, 16s delay0.60.82.90.51.40.2-1.3-0.51.7-0.50.50.21.3-0.10.9-0.9
Delay disc. indifference point, 2s delay1.01.13.61.40.5-1.1-0.50.81.10.8-0.81.30.3-1.4-0.1-1.9
Delay disc. indifference point, 24s delay0.71.12.3-0.41.50.9-1.4-1.01.5-1.01.0-0.61.40.61.1-0.1
Delay disc. indifference point, 4s delay0.70.72.60.61.2-0.0-1.2-0.21.6-0.30.30.41.1-0.40.8-1.1
Delay disc. indifference point, 8s delay0.60.93.00.61.40.2-1.4-0.51.7-0.50.50.21.3-0.11.0-1.0
Indifference point function ln k0.10.30.6-0.1-0.8-0.40.80.5-0.70.6-0.60.4-0.7-0.3-0.70.1
Indifference point function log k0.10.30.6-0.1-0.8-0.40.80.5-0.70.6-0.60.4-0.7-0.3-0.70.1
Patch foraging total patch changes 0 sec0.51.36.6-2.61.01.5-0.8-1.10.8-1.01.0-1.10.41.00.30.8
Patch foraging total patch changes 12 sec1.11.55.3-2.31.21.6-1.0-1.30.8-1.21.2-1.30.61.10.60.9
Patch foraging total patch changes 18 sec1.33.14.6-1.91.92.2-1.9-1.71.6-2.02.0-1.71.51.61.60.7
Patch foraging total patch changes 24 sec0.51.83.0-1.71.31.7-1.3-1.40.9-1.51.5-1.50.91.31.20.7
Patch foraging total patch changes 6 sec1.42.38.5-2.91.31.9-1.1-1.60.8-1.51.5-1.80.71.50.81.2
Patch foraging time to switch 0 sec0.20.84.82.2-0.4-1.10.20.7-0.20.6-0.60.80.1-0.90.1-1.0
Patch foraging water rate 0 sec0.20.96.2-2.50.61.1-0.5-0.70.5-0.50.5-0.80.00.8-0.10.8
Patch foraging water rate 12 sec0.51.96.3-2.51.01.8-0.9-1.30.6-1.51.5-1.60.51.60.61.2
Patch foraging water rate 18 sec0.10.30.7-0.4-0.4-0.40.40.6-0.10.6-0.60.5-0.6-0.5-0.8-0.2
Patch foraging water rate 24 sec0.20.20.7-0.50.4-0.2-0.30.30.70.3-0.30.6-0.1-0.6-0.4-0.8
Patch foraging water rate 6 sec0.10.10.7-0.80.30.2-0.30.10.50.1-0.10.1-0.1-0.1-0.3-0.2
Seeking ratio, delayed vs. immediate footshock1.42.04.00.9-2.0-1.22.01.3-1.91.4-1.40.8-1.6-0.9-1.40.1
Distance traveled before self-admin2.45.27.92.4-1.8-2.61.72.8-1.12.4-2.42.8-1.9-2.7-2.1-2.1
Distance traveled after self-admin1.52.75.22.3-1.0-2.11.01.8-0.41.8-1.82.1-0.9-2.1-1.2-1.8
Extensor digitorum longus weight1.03.98.0-1.72.81.8-2.7-2.02.6-2.02.0-1.22.11.11.8-0.4
Bone: elastic displacement0.30.41.41.10.3-0.6-0.30.40.70.3-0.30.70.2-0.8-0.0-1.2
Bone: elastic work0.60.82.10.6-0.1-1.00.21.00.40.9-0.91.3-0.5-1.3-0.9-1.5
Bone: endosteal estimation0.61.32.0-1.01.31.2-1.3-1.41.1-1.31.3-1.11.21.21.20.4
Bone: endosteal perimeter0.92.24.3-0.72.11.2-2.0-1.42.1-1.51.5-0.91.80.91.6-0.4
Epididymis fat weight6.734.055.8-7.56.46.9-6.1-6.25.3-6.36.3-5.55.15.44.82.6
Delta time in closed arm before/after self-admin0.90.91.30.3-1.1-0.91.10.9-1.01.1-1.10.8-1.1-0.9-1.1-0.4
Delta time in open arm before/after self-admin3.03.54.8-1.01.62.1-1.7-2.11.1-2.22.2-2.11.92.12.21.4
Diff in mean of infusions in LGA sessions0.50.91.6-0.31.30.7-1.3-1.11.1-0.90.9-0.81.20.61.2-0.0
Delay discount exponential model param0.91.24.4-0.6-1.7-0.21.60.5-2.10.5-0.5-0.3-1.50.3-1.11.3
Extinction: sum of active levers before priming1.21.84.5-0.11.80.7-1.8-1.22.0-1.21.2-0.72.10.71.7-0.1
Active lever presses in extinction session 60.60.61.5-0.21.00.4-1.0-0.61.2-0.60.6-0.41.20.30.9-0.1
Bone: final force0.81.47.5-2.70.51.5-0.4-0.90.1-1.01.0-1.20.11.3-0.01.3
Bone: final moment0.91.47.0-2.70.61.5-0.5-1.10.2-1.11.1-1.20.21.40.11.3
Food consumed during 24 hour testing period0.20.41.1-0.1-0.9-0.20.90.4-1.10.4-0.4-0.0-0.80.1-0.60.6
Glucose1.62.64.9-1.12.21.4-2.1-1.72.1-1.71.7-1.11.80.91.6-0.3
Heart weight2.13.312.3-3.51.22.4-1.1-1.70.7-1.81.8-2.00.82.10.71.7
Delay discount hyperbolic model param1.01.34.6-0.7-1.7-0.11.60.4-2.10.4-0.4-0.4-1.50.4-1.11.4
Intermittent access intake day 1-15 change0.10.62.31.50.3-0.9-0.40.70.60.5-0.50.80.1-1.10.1-1.3
Intermittent access intake escalation0.10.41.81.30.3-0.8-0.40.40.40.4-0.40.60.1-0.80.2-0.9
Intermittent access intake escalation 20.20.30.70.8-0.2-0.80.10.5-0.10.6-0.60.6-0.2-0.8-0.2-0.5
Intermitt. access day 1 inactive lever presses0.33.55.7-0.61.91.9-2.0-2.31.4-2.12.1-1.92.11.82.41.0
Intermitt. access day 15 inactive lever presses0.10.81.2-0.61.10.9-1.1-0.90.9-1.01.0-0.71.00.71.00.2
Intermitt. access escalation Index0.00.10.40.6-0.1-0.10.0-0.2-0.10.1-0.1-0.20.3-0.10.3-0.0
Intermittent access day 1 total infusions0.00.10.50.70.0-0.4-0.00.30.10.2-0.20.50.0-0.4-0.0-0.7
Intermittent access day 15 total infusions0.20.62.61.60.3-0.8-0.50.40.60.4-0.40.70.3-0.90.3-1.3
Intermittent access terminal intake (last 3 days)0.20.41.31.20.6-0.5-0.70.20.70.1-0.10.50.5-0.70.5-1.1
Intermittent access total infusions0.10.20.80.90.2-0.4-0.20.20.30.2-0.20.40.1-0.50.2-0.8
Intermittent access day 1 locomotion0.91.74.31.8-0.2-1.60.21.20.41.3-1.31.8-0.3-1.7-0.6-2.1
Intermittent access day 15 total locomotion0.20.92.20.41.40.1-1.4-0.61.5-0.60.6-0.11.2-0.11.1-0.9
Intermittent access total locomotion1.11.33.01.3-0.2-1.50.21.10.31.2-1.21.6-0.3-1.6-0.6-1.7
Intermittent access standard deviation0.21.33.50.81.60.4-1.7-0.61.9-0.80.8-0.11.60.11.5-0.7
Left kidney weight0.21.615.7-4.00.81.4-0.5-0.60.7-0.40.4-0.5-0.40.5-0.70.7
Right kidney weight0.21.110.9-3.31.00.9-0.7-0.31.0-0.00.00.0-0.2-0.0-0.7-0.0
Cocaine induced anxiety1.13.05.30.7-2.2-1.52.21.7-2.31.8-1.81.0-2.3-1.2-2.0-0.1
Post-drug Anxiety0.60.61.8-1.3-0.80.50.90.0-1.2-0.00.0-0.7-1.00.5-0.71.1
Baseline Anxiety2.54.36.3-1.91.92.5-1.9-2.11.5-2.42.4-2.12.02.22.11.4
Tail length0.21.01.5-0.41.21.0-1.2-1.01.0-1.21.2-1.01.20.81.20.2
Length with tail0.94.06.0-2.41.92.5-1.9-2.21.4-2.32.3-2.11.62.01.71.2
Length without tail1.57.711.8-3.42.63.4-2.5-3.11.8-3.13.1-3.02.32.92.41.8
Times rat made contact with spout0.00.00.1-0.3-0.00.10.0-0.0-0.0-0.10.1-0.1-0.10.1-0.10.1
Lifetime Intake0.10.20.60.8-0.2-0.50.20.4-0.20.3-0.30.5-0.2-0.5-0.2-0.5
Liver weight, left2.13.79.2-3.02.42.2-2.2-2.02.1-1.91.9-1.61.51.41.30.5
Liver weight, right0.20.41.9-1.40.80.2-0.7-0.21.00.0-0.00.10.1-0.4-0.1-0.5
Locomotor activity0.10.10.30.50.0-0.4-0.00.20.20.3-0.30.40.1-0.4-0.1-0.4
Locomotor testing distance0.61.52.31.2-0.9-1.50.91.4-0.51.5-1.51.5-1.0-1.5-1.1-1.1
Locomotor testing rearing0.31.13.01.60.1-1.2-0.10.90.61.0-1.01.4-0.1-1.5-0.3-1.7
Locomotion in novel chamber1.41.93.20.5-1.5-1.21.61.5-1.41.6-1.61.2-1.8-1.3-1.7-0.6
Locomotion in novel chamber post-restriction0.72.23.20.6-1.4-1.41.51.7-1.11.7-1.71.6-1.7-1.5-1.8-0.9
Fecal boli incidents, locomotor time 10.00.10.2-0.5-0.10.30.1-0.2-0.3-0.20.2-0.4-0.10.3-0.00.4
Change in fecal boli incidents, locomotor task0.20.31.5-1.2-0.20.50.3-0.1-0.5-0.20.2-0.4-0.60.4-0.40.5
Time >=10cm from walls, locomotor time 10.20.20.6-0.1-0.70.10.60.1-0.80.1-0.1-0.2-0.40.3-0.30.7
Bouts of movement, locomotor time 11.21.62.90.11.61.1-1.7-1.31.6-1.31.3-0.81.60.71.6-0.2
Total resting periods, locomotor time 10.70.81.60.21.20.8-1.3-0.91.2-0.80.8-0.51.10.41.1-0.3
Rest time, locomotor task time 10.40.71.5-0.4-1.0-0.51.00.8-0.90.9-0.90.6-1.2-0.5-1.20.0
Distance moved, locomotor task time 10.10.20.70.60.6-0.2-0.6-0.20.8-0.10.10.20.7-0.30.5-0.7
Vertical activity count, locomotor time 10.00.20.50.40.2-0.5-0.20.40.40.4-0.40.60.1-0.6-0.1-0.7
Time >=10cm from walls, locomotor time 20.20.62.5-1.6-0.70.50.80.1-1.10.1-0.1-0.4-1.00.5-0.81.0
Bouts of movement, locomotor time 20.20.64.02.00.4-0.6-0.50.10.70.2-0.20.70.6-0.70.6-1.2
Total resting periods, locomotor time 20.20.84.52.10.6-0.7-0.70.11.00.2-0.20.80.8-0.80.7-1.4
Rest time, locomotor task time 20.20.41.11.00.1-0.8-0.10.50.40.5-0.50.80.0-0.8-0.1-1.0
Distance moved, locomotor task time 20.20.20.6-0.8-0.60.10.60.1-0.70.1-0.1-0.2-0.60.3-0.60.7
Vertical activity count, locomotor time 20.10.31.2-1.1-0.50.30.60.0-0.70.1-0.1-0.3-0.70.3-0.50.7
Light reinforcement 10.20.71.70.0-0.9-0.61.01.1-0.90.7-0.70.6-1.3-0.6-1.2-0.2
Light reinforcement 20.51.22.20.4-1.5-1.01.51.2-1.41.0-1.00.7-1.4-0.6-1.40.1
Bone: marrow area0.61.42.0-1.11.31.2-1.2-1.41.1-1.31.3-1.11.21.21.10.5
Bone: maximum diameter2.75.36.7-2.22.62.5-2.5-2.52.1-2.62.6-2.22.32.22.30.9
Bone: maximum force0.61.27.5-2.70.11.30.0-0.8-0.3-0.70.7-1.1-0.31.2-0.31.5
Bone: maximum moment0.71.37.1-2.70.21.4-0.1-0.9-0.2-0.80.8-1.2-0.21.3-0.11.5
Mean time between licks in bursts0.21.22.1-0.40.41.2-0.5-1.2-0.1-1.21.2-1.50.91.51.21.4
Mean num. licks in bursts0.61.64.51.40.1-1.40.01.20.71.2-1.21.7-0.3-1.8-0.7-2.1
Cd content in liver4.55.08.10.6-2.8-2.02.82.4-2.52.4-2.41.6-2.8-1.6-2.70.1
Co content in liver1.72.03.6-0.3-1.7-1.21.81.6-1.41.6-1.61.0-1.8-1.0-1.90.1
Cu content in liver0.40.50.80.8-0.7-0.80.70.9-0.50.8-0.80.8-0.6-0.8-0.6-0.3
Fe content in liver2.32.84.7-2.21.02.1-1.0-1.90.3-1.91.9-2.11.02.11.31.8
K content in liver0.40.41.51.20.5-0.4-0.50.10.80.0-0.00.40.7-0.50.6-0.8
Mg content in liver1.11.24.42.10.7-1.0-0.80.41.30.4-0.41.10.7-1.20.5-1.9
Mn content in liver0.20.20.80.40.6-0.3-0.50.10.90.1-0.10.30.4-0.40.2-0.8
Na content in liver0.91.02.71.31.2-0.3-1.2-0.21.7-0.20.20.51.3-0.60.9-1.4
Rb content in liver0.40.41.10.60.90.2-0.9-0.51.0-0.50.5-0.11.00.00.9-0.4
Se content in liver0.10.20.4-0.6-0.50.20.5-0.0-0.6-0.10.1-0.5-0.40.3-0.20.7
Sr content in liver2.21.93.11.5-1.2-1.81.21.6-0.81.6-1.61.4-1.3-1.6-1.2-1.1
Zn content in liver2.32.75.72.4-0.8-2.10.71.8-0.11.7-1.72.1-0.9-2.2-1.0-2.0
Bone: minimum diameter1.32.56.1-2.51.62.0-1.4-1.61.2-1.71.7-1.61.11.71.11.0
Time in familiar zone, hab. session 10.50.51.80.40.7-0.5-0.70.31.10.4-0.40.90.3-1.0-0.1-1.4
Time in novel zone, hab. session 10.91.02.4-0.70.01.2-0.1-1.1-0.5-1.11.1-1.40.51.50.81.5
Total zone transitions, hab. session 10.10.10.4-0.30.1-0.2-0.00.40.40.2-0.20.5-0.3-0.4-0.4-0.6
Total locomotion distance, hab. session 10.50.72.6-1.4-0.50.90.5-0.5-0.9-0.40.4-0.9-0.41.0-0.11.6
Locomotion velocity, hab. session 10.40.62.1-1.2-0.60.70.7-0.3-1.0-0.30.3-0.8-0.50.9-0.31.4
Time in familiar zone, hab. session 21.51.72.5-0.71.11.5-1.2-1.50.7-1.61.6-1.51.31.41.40.8
Time in novel zone, hab. session 21.11.21.70.6-1.0-1.21.01.3-0.61.3-1.31.3-1.1-1.2-1.2-0.7
Total zone transitions, hab. session 20.20.20.90.50.2-0.5-0.10.50.50.3-0.30.7-0.0-0.7-0.2-1.0
Total locomotion distance, hab. session 20.00.10.5-0.70.00.2-0.0-0.2-0.0-0.00.0-0.1-0.10.1-0.10.3
Locomotion velocity, hab. session 20.00.00.2-0.50.20.1-0.1-0.10.20.0-0.00.00.0-0.0-0.00.0
Novel to familiar place preference ratio0.81.02.9-1.5-0.21.20.2-0.8-0.7-0.90.9-1.3-0.01.40.31.7
Novelty place preference0.60.72.1-1.2-0.11.10.1-0.8-0.6-0.80.8-1.10.11.20.31.5
Time in novel zone, NPP test1.21.53.0-1.60.31.6-0.3-1.3-0.3-1.21.2-1.60.41.70.71.7
Total zone transitions, NPP test0.00.00.1-0.1-0.1-0.20.10.30.10.1-0.10.2-0.2-0.2-0.3-0.3
Total locomotion distance, NPP test0.40.61.4-1.1-0.90.21.00.2-1.20.3-0.3-0.2-1.00.4-0.81.0
Locomotion velocity, NPP test0.71.12.4-0.7-1.4-0.41.50.8-1.60.8-0.80.2-1.5-0.1-1.30.8
Intraocular pressure1.52.43.5-1.81.21.9-1.2-1.80.9-1.71.7-1.91.31.71.41.3
Delta distance traveled before/after self-admin0.40.41.30.60.9-0.0-0.9-0.41.1-0.10.10.10.9-0.20.7-0.7
Delta ambulatory time before/after self-admin0.30.61.40.11.00.4-1.0-0.81.2-0.50.5-0.31.10.21.0-0.3
Parametrial fat weight9.121.529.2-5.45.45.2-5.1-4.94.6-5.15.1-4.24.24.14.01.4
Pavlov. Cond. lever latency0.30.40.90.30.60.5-0.6-0.70.4-0.60.6-0.60.80.51.00.3
Pavlov. Cond. magazine entry latency0.00.00.0-0.10.1-0.0-0.10.10.2-0.10.10.00.0-0.0-0.1-0.2
Pavlov. Cond. change in total contacts0.10.10.4-0.20.5-0.1-0.40.00.60.1-0.10.30.2-0.3-0.0-0.6
Pavlov. Cond. index score0.00.00.2-0.30.3-0.1-0.20.10.4-0.00.00.20.1-0.2-0.1-0.4
Pavlov. Cond. latency score0.00.00.1-0.20.1-0.2-0.00.20.20.1-0.10.2-0.1-0.2-0.3-0.4
Pavlov. Cond. lever contacts0.00.10.2-0.20.2-0.2-0.10.20.30.1-0.10.3-0.0-0.3-0.2-0.5
Pavlov. Cond. magazine entry number0.10.10.4-0.1-0.50.10.50.0-0.60.2-0.2-0.2-0.40.2-0.20.6
Pavlov. Cond. intertrial magazine entries0.60.73.5-1.9-0.70.30.80.2-1.00.3-0.3-0.2-1.10.2-1.01.0
Pavlov. Cond. lever-magazine prob. diff.0.00.10.2-0.40.3-0.0-0.30.00.4-0.10.10.10.1-0.0-0.1-0.3
Pavlov. Cond. response bias0.10.10.30.20.1-0.4-0.00.30.20.2-0.20.4-0.1-0.4-0.3-0.6
Pavlov. Cond. lever latency1.31.82.71.1-1.1-1.61.11.6-0.71.5-1.51.5-1.3-1.5-1.4-1.2
Pavlov. Cond. magazine entry latency0.91.22.30.11.30.9-1.4-1.31.2-1.21.2-0.81.50.71.50.1
Pavlov. Cond. change in total contacts0.51.11.8-0.51.01.2-1.0-1.40.8-1.21.2-1.11.31.11.30.7
Pavlov. Cond. index score1.11.72.6-0.71.31.4-1.3-1.61.1-1.41.4-1.31.51.31.50.7
Pavlov. Cond. latency score0.91.52.2-0.61.21.3-1.2-1.51.0-1.31.3-1.21.41.21.40.7
Pavlov. Cond. lever contacts0.61.01.5-1.00.81.2-0.7-1.20.5-1.01.0-1.10.91.10.91.0
Pavlov. Cond. magazine entry number0.70.91.60.1-1.2-0.81.21.1-1.11.0-1.00.7-1.3-0.6-1.2-0.1
Pavlov. Cond. intertrial magazine entries0.10.11.0-1.00.20.4-0.2-0.10.2-0.20.2-0.2-0.10.2-0.20.1
Pavlov. Cond. lever-magazine prob. diff.0.81.32.0-0.51.21.2-1.2-1.41.0-1.21.2-1.01.41.11.40.5
Pavlov. Cond. response bias1.41.93.1-1.11.21.6-1.2-1.70.8-1.51.5-1.51.41.61.51.2
Time in closed arm before self-admin0.10.20.60.50.4-0.5-0.30.30.80.4-0.40.60.4-0.6-0.0-0.8
Time in closed arm after self-admin1.61.83.51.5-0.8-1.70.81.40.01.7-1.71.9-0.5-1.7-1.1-1.3
Time in open arm before self-admin0.60.83.00.2-1.3-0.31.30.5-1.70.5-0.50.1-1.3-0.1-0.80.5
Time in open arm after self-admin1.41.63.0-0.70.71.5-0.8-1.4-0.0-1.61.6-1.70.81.71.41.2
Bone: periosteal estimation1.12.78.0-2.81.52.0-1.3-1.71.0-1.71.7-1.71.01.80.91.2
Bone: periosteal perimeter2.04.06.5-2.02.62.1-2.4-2.02.4-2.12.1-1.62.11.61.80.3
Bone: post-yield work1.11.96.0-2.5-0.31.50.4-1.0-1.0-1.01.0-1.7-0.41.80.02.3
Progressive ratio test 1 active lever presses0.50.93.61.9-0.1-1.20.10.70.30.8-0.81.20.1-1.1-0.1-1.2
Progressive ratio test 1 breakpoint0.50.83.41.9-0.2-1.10.10.70.30.8-0.81.20.1-1.1-0.1-1.2
Progressive ratio test 1 inactive lever presses0.10.20.60.20.70.2-0.7-0.70.6-0.30.3-0.10.80.20.7-0.1
Progressive ratio test 2 active lever presses0.30.41.10.90.7-0.4-0.80.11.00.1-0.10.50.6-0.60.5-1.1
Progressive ratio test 2 breakpoint0.30.41.00.90.8-0.4-0.80.01.00.0-0.00.40.7-0.50.5-1.0
Progressive ratio test 2 inactive lever presses0.10.20.6-0.40.00.4-0.0-0.7-0.3-0.40.4-0.50.20.60.40.8
Incentive Sensitization - Responses0.30.72.10.31.40.2-1.4-0.61.5-0.50.5-0.11.1-0.11.0-0.7
Incentive Sensitization - Breakpoint0.40.82.20.21.40.3-1.4-0.71.5-0.60.6-0.21.10.11.1-0.6
Sum of active levers in priming session hrs 5-61.51.42.70.31.50.7-1.6-1.11.5-1.11.1-0.81.70.61.6-0.2
Progressive ratio0.20.51.60.8-1.2-0.41.20.4-1.30.4-0.40.1-0.60.0-0.40.7
Food seeking constrained by brief footshock0.00.00.20.1-0.5-0.10.40.2-0.30.1-0.10.0-0.10.1-0.10.1
Seeking ratio, punishment vs. effort0.20.52.00.10.7-0.4-0.70.31.10.3-0.30.70.3-0.8-0.0-1.4
Retroperitoneal fat weight9.241.482.9-9.17.17.6-6.7-6.85.9-6.86.8-6.05.25.94.92.8
Reaction time number correct0.31.02.41.01.40.2-1.4-0.61.6-0.60.60.11.50.11.3-0.8
Reaction time mean minus median0.21.23.50.91.50.2-1.6-0.41.9-0.60.60.31.5-0.21.2-1.1
Reaction time mean minus median AUC0.32.25.62.41.5-0.8-1.60.42.30.2-0.21.41.5-1.30.9-2.4
Reaction time num false alarms0.30.51.1-0.6-0.8-0.30.90.7-0.70.7-0.70.5-0.9-0.4-1.00.3
Reaction time num false alarms AUC0.30.61.2-0.2-0.8-0.70.90.9-0.50.9-0.90.8-0.8-0.7-1.1-0.1
Reaction time trials correct on left0.31.02.41.01.40.2-1.4-0.61.6-0.60.60.11.50.11.3-0.8
Reaction time trials on left0.31.22.81.11.50.3-1.5-0.71.7-0.70.70.01.60.11.4-0.9
Reaction time mean0.92.16.52.61.3-0.9-1.40.32.00.2-0.21.21.5-1.31.0-2.3
Reaction time mean AUC1.12.58.32.91.4-1.1-1.50.42.20.3-0.31.41.5-1.51.0-2.6
Median of all reaction times1.52.38.62.91.0-1.3-1.10.61.80.6-0.61.61.2-1.60.7-2.6
Reaction time omissions1.83.06.40.62.40.9-2.5-1.52.5-1.51.5-0.62.40.62.2-0.9
Reaction time false alarm rate0.81.12.3-1.1-1.4-0.41.50.8-1.30.9-0.90.4-1.5-0.4-1.50.7
Reaction time premature initiation rate0.30.40.8-0.2-0.5-0.50.60.8-0.30.8-0.80.8-0.6-0.6-0.9-0.2
Reaction time premature initiations0.10.20.60.40.3-0.3-0.20.40.60.4-0.40.70.3-0.5-0.1-0.7
Std. dev. reaction times0.61.95.91.02.00.3-2.0-0.62.4-0.80.80.22.0-0.21.5-1.4
Reaction time trials completed0.31.22.81.11.50.3-1.5-0.71.7-0.70.70.01.60.11.4-0.9
Reaction time trials AUC0.31.12.70.91.40.3-1.5-0.71.6-0.70.70.01.60.11.3-0.8
Run reversals in cocaine runway, females0.20.20.5-0.10.50.3-0.5-0.60.6-0.10.1-0.10.70.10.60.1
Run reversals in cocaine runway, males0.50.61.10.5-0.6-1.10.61.1-0.20.7-0.70.9-0.6-0.8-0.9-1.0
Latency to leave start box in cocaine runway0.71.04.32.10.9-0.4-1.0-0.21.4-0.00.00.61.4-0.51.1-1.0
Latency to leave start box in cocaine runway, F0.50.61.41.00.90.0-1.0-0.51.1-0.30.30.01.2-0.01.0-0.6
Latency to leave start box in cocaine runway, M0.70.63.01.70.3-0.7-0.40.40.80.5-0.50.90.6-0.80.3-1.0
Std. dev. time between licks in bursts0.40.83.2-0.8-1.00.61.0-0.3-1.5-0.20.2-0.9-0.60.9-0.21.8
Total sessions with >9 infusions0.40.50.80.6-0.9-0.80.90.7-0.70.8-0.80.8-0.6-0.5-0.8-0.0
Short access day 1 total inactive lever presses0.30.63.1-0.6-0.50.50.6-0.8-0.9-0.40.4-0.80.11.10.11.8
Short access day 10 total inactive lever presses0.00.20.7-0.50.70.3-0.6-0.60.8-0.10.1-0.00.70.00.30.0
Short access day 1 total infusions0.10.20.70.5-0.4-0.80.40.4-0.00.6-0.60.7-0.0-0.5-0.4-0.3
Short access day 10 total infusions1.11.93.11.8-1.3-1.71.31.5-0.81.5-1.51.6-0.9-1.4-1.1-0.8
Short access total infusions0.71.01.41.1-1.2-1.21.21.1-0.91.0-1.01.0-0.8-0.7-1.0-0.3
Short access day 1 locomotion0.30.52.11.40.3-0.8-0.30.20.80.4-0.40.90.7-0.60.3-0.6
Short access day 10 total locomotion0.31.22.71.6-0.3-1.60.31.00.61.2-1.21.70.1-1.4-0.6-1.4
Short access total locomotion1.72.54.52.0-1.2-2.11.21.7-0.51.8-1.82.1-0.8-1.8-1.3-1.3
One hour access (0.3 mA shock)0.81.02.30.21.20.7-1.3-1.10.9-1.11.1-0.81.20.71.50.0
Compulsive drug intake0.81.21.9-0.91.21.1-1.2-1.41.0-1.11.1-1.01.21.01.10.4
One hour access (shock baseline)0.10.21.31.1-0.3-0.60.20.5-0.40.3-0.30.4-0.3-0.5-0.0-0.5
Social response proportion0.40.61.3-0.1-0.0-0.90.10.50.40.9-0.91.1-0.4-1.1-0.8-1.1
Social responses0.60.82.5-1.61.11.0-1.0-0.90.9-0.90.9-0.80.60.70.50.1
Social time0.91.45.01.70.9-1.0-0.90.41.40.6-0.61.30.6-1.50.3-2.2
Soleus weight1.54.414.51.52.9-0.7-2.8-0.23.8-0.10.11.52.0-1.81.2-3.6
Bone: stiffness0.71.36.4-2.5-0.11.30.2-0.7-0.6-0.80.8-1.2-0.31.4-0.21.8
Tibialis anterior weight0.93.27.30.42.71.0-2.7-1.62.7-1.51.5-0.52.40.32.1-1.3
Time to tail flick, vehicle, before self-admin0.50.61.7-1.3-0.70.70.7-0.2-1.1-0.20.2-0.7-0.70.8-0.51.2
Time to tail flick, vehicle, after self-admin0.10.10.9-1.00.20.3-0.2-0.30.0-0.30.3-0.4-0.10.20.00.1
Time to tail flick, test, before self-admin2.63.05.11.8-1.3-2.21.31.9-0.52.1-2.12.3-1.1-2.1-1.5-1.5
Time to tail flick, test, after self-admin0.60.61.4-0.50.20.8-0.3-0.9-0.2-0.90.9-1.20.51.10.71.0
Delta time to tail flick, vehicle, before/after SA1.01.12.5-0.01.50.5-1.6-0.91.5-0.90.9-0.71.30.41.3-0.4
Delta time to tail flick, test, before/after SA1.21.43.2-1.40.51.5-0.5-1.3-0.3-1.41.4-1.80.41.60.81.4
Tibia length0.00.10.8-0.9-0.20.10.30.1-0.30.1-0.1-0.0-0.40.1-0.50.2
Ambulatory time before self-admin1.13.45.21.8-1.7-2.11.62.3-1.12.0-2.02.2-1.7-2.0-1.9-1.4
Ambulatory time after self-admin1.01.63.21.8-0.5-1.70.51.30.01.4-1.41.7-0.5-1.7-0.7-1.6
Bone: tissue strength0.10.10.1-0.0-0.10.20.0-0.2-0.2-0.20.2-0.40.10.30.20.4
Total heroin consumption2.63.15.0-1.02.21.4-2.2-1.72.2-1.81.8-1.42.21.32.00.3
Bone: trabecular number1.93.66.6-2.61.42.5-1.3-2.20.6-2.02.0-2.21.32.21.51.9
Bone: trabecular spacing0.20.41.81.3-0.7-0.70.60.7-0.60.4-0.40.4-0.3-0.3-0.2-0.1
Bone: trabecular thickness2.12.95.2-2.32.12.0-1.9-2.01.7-1.71.7-1.51.51.41.40.6
Bone: trabecular tissue density1.22.15.82.4-0.7-1.80.61.6-0.11.5-1.51.7-0.6-1.9-0.7-1.8
Water consumed over 24 hours0.20.30.50.6-0.5-0.70.50.6-0.30.7-0.70.7-0.5-0.6-0.5-0.4
Number of responses in last shaping day0.20.30.70.7-0.3-0.70.30.5-0.10.7-0.70.7-0.4-0.9-0.4-0.6