Hub : Genes

Ccdc73

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IC gene expression Ccdc73 0.26 0.17 5.4e-08 0.15 0.18 0.17 0.17 1.1e-06 7.1e-08 1.6e-07 1.1e-07
2 Brain gene expression Ccdc73 0.35 0.18 0.0e+00 0.29 0.3 0.29 0.29 1.7e-27 2.3e-28 2.1e-27 2.1e-27
3 Adipose gene expression Ccdc73 0.12 0.09 7.9e-14 0.1 0.11 0.11 0.11 1.0e-11 1.6e-12 2.9e-12 3.6e-12
4 NAcc gene expression Ccdc73 0.16 0.09 0.0e+00 0.23 0.24 0.24 0.23 4.6e-34 1.2e-35 2.0e-35 4.8e-35
5 OFC gene expression Ccdc73 0.37 0.2 8.5e-07 0.19 0.19 0.16 0.18 2.7e-05 2.3e-05 1.3e-04 4.8e-05
6 BLA gene expression Ccdc73 0.26 0.14 5.3e-15 0.26 0.08 0.27 0.17 2.9e-14 4.5e-05 2.2e-14 2.4e-09
7 pVTA mRNA stability Ccdc73 0.05 0.04 4.7e-04 0.04 0.04 0.04 0.04 4.3e-04 2.2e-04 1.6e-04 2.1e-04
8 pVTA gene expression Ccdc73 0.18 0.11 0.0e+00 0.21 0.22 0.22 0.22 4.1e-17 6.9e-18 1.9e-17 2.1e-17
9 IL gene expression Ccdc73 0.36 0.17 3.9e-09 0.34 0.33 0.28 0.32 7.2e-09 9.7e-09 1.6e-07 1.6e-08
10 NAcc mRNA stability Ccdc73 0.03 0.03 1.6e-04 0.03 0.02 0.02 0.03 3.8e-05 1.2e-04 1.3e-04 8.7e-05
11 PL gene expression Ccdc73 0.48 0.26 0.0e+00 0.29 0.28 0.31 0.3 1.3e-31 2.0e-30 2.7e-34 1.0e-32

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.71.31.51.21.21.11.11.11.2-0.91.01.2-1.21.1
Area under the delay curve0.10.10.1-0.3-0.2-0.3-0.4-0.3-0.30.3-0.4-0.30.30.1
BMI with tail0.00.10.20.30.40.20.10.20.2-0.20.10.4-0.40.4
BMI without tail0.20.71.10.70.70.70.70.80.8-0.60.81.1-1.10.9
Body weight0.73.03.91.81.71.81.81.81.8-1.71.82.0-2.01.1
Weight adjusted by age0.10.20.4-0.2-0.1-0.4-0.6-0.5-0.40.4-0.6-0.20.20.2
Bone surface0.30.50.70.80.80.70.70.70.8-0.60.70.8-0.80.3
Bone volume0.81.41.71.31.31.21.21.21.3-1.11.21.2-1.21.0
Breakpoint value in progressive ratio session1.01.22.2-1.2-1.2-1.1-1.0-1.1-1.11.1-1.0-0.80.8-1.5
Number of licking bursts0.30.51.00.70.80.60.60.60.6-0.70.50.6-0.61.0
Context. condit. distance diff. score4.45.35.82.32.32.42.42.42.3-2.32.42.2-2.22.2
Locomotion velocity, session 11.71.82.1-1.5-1.5-1.4-1.3-1.3-1.41.4-1.3-1.41.4-1.0
Locomotion distance, session 10.20.20.3-0.5-0.4-0.5-0.5-0.5-0.50.4-0.5-0.50.5-0.0
Locomotion velocity, session 20.00.00.2-0.1-0.0-0.0-0.0-0.0-0.0-0.1-0.0-0.00.00.4
Locomotion distance, session 20.00.00.1-0.1-0.2-0.1-0.0-0.0-0.00.10.0-0.00.00.3
Locomotion velocity, session 30.10.10.40.50.60.30.20.20.4-0.30.10.4-0.40.5
Locomotion distance, session 30.20.21.30.40.50.30.30.30.3-0.30.30.3-0.31.1
Stereotopy head waving bouts, day 30.10.20.5-0.2-0.1-0.4-0.5-0.5-0.30.4-0.6-0.20.2-0.7
Stereotopy head waving duration, day 30.20.20.30.50.50.40.40.40.5-0.40.40.6-0.6-0.2
Locomotion velocity, session 70.10.10.20.20.20.30.40.40.2-0.30.40.1-0.10.4
Locomotion distance, session 70.10.10.3-0.5-0.5-0.3-0.3-0.3-0.40.3-0.2-0.50.50.0
Stereotopy head waving bouts, day 70.00.00.2-0.00.0-0.2-0.2-0.2-0.10.2-0.4-0.00.0-0.4
Stereotopy head waving duration, day 70.00.00.2-0.1-0.0-0.2-0.2-0.2-0.10.2-0.3-0.00.0-0.5
Locomotion velocity, session 80.20.20.40.40.30.50.50.50.4-0.50.50.3-0.30.6
Locomotion distance, session 82.73.95.31.91.82.02.02.02.0-1.92.11.9-1.92.3
Degree of sensitization distance0.50.51.4-0.8-0.9-0.5-0.4-0.5-0.70.5-0.3-0.70.7-1.2
Degree of sensitization stereotypy0.20.20.4-0.3-0.3-0.5-0.5-0.5-0.40.5-0.6-0.30.3-0.6
Conditioned locomotion5.96.87.7-2.5-2.4-2.6-2.7-2.7-2.72.5-2.8-2.72.7-2.4
Cocaine response after cond. corrected4.15.07.5-2.2-2.2-2.1-2.1-2.1-2.32.1-2.1-2.32.3-2.7
Cocaine response after cond. not corrected1.31.53.5-1.2-1.2-1.1-1.1-1.1-1.21.1-1.1-1.21.2-1.9
Cocaine response before conditioning6.47.78.62.72.72.72.72.72.8-2.72.72.9-2.92.7
Saline control response0.10.20.50.30.40.40.30.30.3-0.40.30.4-0.40.7
Bone: connectivity density0.71.11.31.11.11.01.01.01.1-0.80.91.1-1.11.0
Bone: cortical apparent density0.10.10.20.30.20.30.40.40.3-0.30.40.2-0.2-0.1
Bone: cortical area0.71.11.21.01.01.11.11.11.0-1.11.11.1-1.10.9
Bone: cortical porosity0.20.20.3-0.5-0.5-0.5-0.5-0.5-0.50.4-0.5-0.40.4-0.3
Bone: cortical porosity0.10.10.1-0.4-0.4-0.3-0.3-0.3-0.30.3-0.3-0.20.2-0.1
Bone: cortical thickness0.10.10.10.30.30.40.40.40.3-0.30.40.3-0.30.1
Bone: cortical thickness1.41.61.9-1.2-1.2-1.3-1.3-1.3-1.21.3-1.4-1.21.2-1.3
Bone: cortical tissue density0.10.10.10.30.20.30.40.30.2-0.20.40.2-0.2-0.1
Condit. Reinf. active minus inactive responses2.52.83.21.71.71.71.71.71.7-1.61.61.8-1.81.5
Condit. Reinf. active-inactive response ratio7.17.68.52.92.82.82.82.82.9-2.72.72.9-2.92.3
Condit. Reinf. active responses0.40.50.50.70.70.70.70.70.7-0.60.70.7-0.70.7
Condit. Reinf. inactive responses2.22.73.2-1.7-1.8-1.6-1.6-1.6-1.71.7-1.5-1.71.7-1.5
Incentive salience index mean1.61.92.21.41.41.41.41.41.4-1.31.41.5-1.51.2
Condit. Reinf. lever presses0.30.50.60.60.60.70.70.70.7-0.60.70.8-0.80.7
Condit. Reinf. active minus inactive responses1.72.22.51.51.41.51.51.51.5-1.61.61.6-1.61.2
Condit. Reinf. active-inactive response ratio4.65.35.82.22.22.32.42.42.3-2.42.42.4-2.42.0
Condit. Reinf. active responses1.11.51.71.21.21.21.21.21.2-1.31.21.3-1.30.9
Condit. Reinf. inactive responses0.00.00.1-0.1-0.0-0.2-0.3-0.3-0.20.2-0.3-0.20.2-0.3
Condit. Reinf. lever presses1.62.32.51.51.51.51.51.51.5-1.61.51.6-1.61.3
Condit. Reinf. lever reinforcers received1.21.71.91.31.31.31.31.31.3-1.31.31.4-1.41.1
Conditioned reinforcement - actives4.37.48.22.82.92.82.72.72.7-2.82.72.5-2.52.7
Conditioned reinforcement - inactives8.712.817.13.63.83.63.53.53.5-3.63.43.3-3.34.1
Conditioned locomotion4.15.36.92.52.62.32.22.22.3-2.42.12.2-2.22.4
Patch foraging indifference point 0 sec0.00.10.30.20.4-0.1-0.2-0.2-0.0-0.1-0.40.2-0.20.6
Patch foraging indifference point AUC0.91.42.0-1.1-1.2-1.1-1.1-1.1-1.21.2-1.1-1.11.1-1.4
Delay disc. indifference point, 0s delay0.10.20.90.30.30.30.30.40.3-0.30.40.1-0.10.9
Delay disc. indifference point, 16s delay0.50.50.7-0.7-0.7-0.8-0.8-0.8-0.70.8-0.9-0.60.6-0.6
Delay disc. indifference point, 2s delay0.10.20.60.40.60.40.30.30.3-0.40.3-0.00.00.7
Delay disc. indifference point, 24s delay0.50.60.7-0.7-0.7-0.8-0.8-0.8-0.70.7-0.8-0.70.7-0.8
Delay disc. indifference point, 4s delay0.30.30.4-0.5-0.5-0.6-0.6-0.6-0.60.6-0.6-0.50.5-0.2
Delay disc. indifference point, 8s delay0.00.00.00.00.00.10.00.0-0.0-0.00.0-0.00.00.2
Indifference point function ln k0.61.11.60.90.91.01.01.01.0-1.11.01.1-1.11.3
Indifference point function log k0.61.11.60.90.91.01.01.01.0-1.11.01.1-1.11.3
Patch foraging total patch changes 0 sec0.00.10.40.20.4-0.0-0.2-0.20.0-0.1-0.30.2-0.20.6
Patch foraging total patch changes 12 sec0.10.20.30.50.60.40.40.30.3-0.50.30.4-0.40.3
Patch foraging total patch changes 18 sec0.10.10.3-0.10.1-0.3-0.4-0.4-0.20.3-0.5-0.10.1-0.4
Patch foraging total patch changes 24 sec0.10.10.4-0.10.1-0.4-0.5-0.5-0.20.3-0.6-0.10.1-0.2
Patch foraging total patch changes 6 sec0.10.10.2-0.10.0-0.3-0.3-0.3-0.20.2-0.4-0.20.20.4
Patch foraging time to switch 0 sec0.30.71.00.91.00.80.80.80.9-0.80.70.8-0.80.8
Patch foraging water rate 0 sec0.00.00.2-0.1-0.1-0.1-0.1-0.1-0.20.1-0.1-0.10.1-0.4
Patch foraging water rate 12 sec0.00.10.2-0.3-0.4-0.3-0.2-0.2-0.30.2-0.2-0.10.1-0.5
Patch foraging water rate 18 sec0.30.50.60.70.70.70.70.70.6-0.80.80.6-0.60.6
Patch foraging water rate 24 sec0.00.00.10.10.10.20.20.30.1-0.20.30.3-0.30.2
Patch foraging water rate 6 sec0.10.10.1-0.3-0.4-0.3-0.3-0.3-0.30.3-0.2-0.30.3-0.2
Seeking ratio, delayed vs. immediate footshock0.10.20.30.30.30.40.40.40.4-0.40.50.6-0.60.3
Distance traveled before self-admin0.10.10.20.30.30.30.20.20.2-0.40.20.3-0.3-0.1
Distance traveled after self-admin0.50.60.80.80.80.80.80.80.7-0.90.70.9-0.90.2
Extensor digitorum longus weight0.10.50.6-0.7-0.7-0.7-0.7-0.7-0.80.7-0.7-0.60.6-0.8
Bone: elastic displacement0.40.50.6-0.7-0.8-0.7-0.7-0.7-0.70.8-0.7-0.70.7-0.7
Bone: elastic work0.00.00.00.10.1-0.0-0.1-0.10.00.0-0.1-0.00.0-0.2
Bone: endosteal estimation0.00.10.1-0.2-0.2-0.3-0.3-0.3-0.30.2-0.3-0.20.2-0.1
Bone: endosteal perimeter0.30.50.90.70.70.70.70.70.7-0.80.70.7-0.70.9
Epididymis fat weight1.34.34.62.12.02.12.12.12.1-2.12.12.1-2.11.8
Delta time in closed arm before/after self-admin0.20.20.2-0.4-0.3-0.4-0.4-0.4-0.40.4-0.5-0.40.4-0.3
Delta time in open arm before/after self-admin0.20.20.4-0.3-0.3-0.4-0.4-0.4-0.40.5-0.4-0.50.5-0.6
Diff in mean of infusions in LGA sessions0.20.20.9-0.4-0.4-0.4-0.4-0.4-0.40.5-0.4-0.40.4-1.0
Delay discount exponential model param0.10.10.20.30.30.40.40.40.4-0.40.50.4-0.40.1
Extinction: sum of active levers before priming0.10.10.3-0.3-0.4-0.3-0.2-0.2-0.30.3-0.2-0.20.2-0.6
Active lever presses in extinction session 60.60.60.70.80.80.80.70.70.7-0.80.70.8-0.80.8
Bone: final force0.30.50.60.70.70.70.70.70.6-0.70.70.5-0.50.8
Bone: final moment0.20.30.40.60.60.60.60.60.5-0.60.60.4-0.40.6
Food consumed during 24 hour testing period3.54.85.82.02.02.22.32.32.1-2.32.42.1-2.12.1
Glucose2.03.13.91.71.61.81.91.91.8-1.82.01.7-1.71.4
Heart weight0.20.40.6-0.6-0.6-0.7-0.7-0.7-0.50.8-0.7-0.40.4-0.1
Delay discount hyperbolic model param0.20.20.30.40.40.50.50.50.5-0.50.50.6-0.60.1
Intermittent access intake day 1-15 change1.02.03.01.51.71.51.41.41.3-1.61.31.0-1.01.7
Intermittent access intake escalation1.22.43.11.71.81.61.61.61.5-1.71.51.1-1.11.8
Intermittent access intake escalation 21.41.61.81.31.31.31.31.31.2-1.41.31.0-1.01.4
Intermitt. access day 1 inactive lever presses0.83.23.81.81.81.91.91.91.8-1.81.91.6-1.61.7
Intermitt. access day 15 inactive lever presses0.81.72.01.41.31.41.41.41.4-1.31.41.3-1.30.8
Intermitt. access escalation Index0.60.81.1-0.9-0.9-0.8-0.8-0.8-0.90.8-0.8-1.01.0-1.1
Intermittent access day 1 total infusions2.43.84.32.12.12.02.02.02.0-2.02.01.8-1.81.5
Intermittent access day 15 total infusions3.85.67.02.62.72.52.42.42.4-2.52.41.9-1.92.3
Intermittent access terminal intake (last 3 days)2.93.94.92.12.22.12.02.01.9-2.22.01.5-1.51.9
Intermittent access total infusions3.44.14.82.22.22.12.12.12.0-2.12.11.6-1.62.0
Intermittent access day 1 locomotion2.83.55.11.92.01.81.81.81.9-1.91.71.7-1.72.3
Intermittent access day 15 total locomotion0.81.43.31.31.51.10.91.01.1-1.10.81.0-1.01.8
Intermittent access total locomotion3.74.48.02.22.32.01.91.92.0-2.11.81.9-1.92.8
Intermittent access standard deviation1.53.23.51.91.91.91.91.91.9-1.81.81.6-1.61.7
Left kidney weight1.14.95.42.22.22.32.32.32.2-2.22.32.3-2.31.6
Right kidney weight1.77.68.12.82.72.82.82.82.8-2.82.92.8-2.82.3
Cocaine induced anxiety0.20.31.10.50.60.50.50.50.5-0.50.50.5-0.51.0
Post-drug Anxiety0.20.20.4-0.4-0.4-0.4-0.4-0.4-0.50.4-0.4-0.60.6-0.5
Baseline Anxiety3.03.56.1-1.8-1.9-1.8-1.7-1.7-1.91.7-1.7-1.91.9-2.5
Tail length0.31.21.81.00.81.11.31.21.2-1.01.41.2-1.20.3
Length with tail1.25.26.22.32.12.42.52.42.4-2.32.52.4-2.41.0
Length without tail1.34.14.72.12.02.12.12.12.1-2.22.12.2-2.20.8
Times rat made contact with spout0.40.40.50.60.60.60.60.60.6-0.70.60.6-0.60.7
Lifetime Intake3.03.74.12.02.02.02.02.01.9-2.02.01.5-1.51.9
Liver weight, left2.84.65.12.12.12.22.22.22.1-2.32.22.2-2.21.9
Liver weight, right1.73.03.51.61.61.81.81.81.7-1.81.91.8-1.81.5
Locomotor activity0.00.00.2-0.2-0.2-0.2-0.2-0.2-0.10.2-0.20.1-0.1-0.4
Locomotor testing distance1.62.93.61.71.61.71.71.71.8-1.71.71.9-1.91.1
Locomotor testing rearing0.30.70.90.90.80.80.80.80.9-0.80.81.0-1.00.3
Locomotion in novel chamber0.70.91.41.01.00.90.90.90.9-1.00.90.9-0.91.2
Locomotion in novel chamber post-restriction0.61.01.2-1.0-1.1-1.1-1.1-1.0-0.91.1-1.0-1.11.1-0.5
Fecal boli incidents, locomotor time 14.26.17.4-2.6-2.7-2.6-2.6-2.6-2.42.6-2.5-2.02.0-2.6
Change in fecal boli incidents, locomotor task2.42.33.41.71.71.61.51.51.5-1.51.51.2-1.21.9
Time >=10cm from walls, locomotor time 10.91.01.6-1.1-1.3-1.0-0.9-0.9-0.91.2-0.8-0.80.8-1.1
Bouts of movement, locomotor time 10.10.10.5-0.1-0.2-0.1-0.1-0.1-0.20.3-0.1-0.30.3-0.7
Total resting periods, locomotor time 10.20.20.8-0.3-0.5-0.3-0.3-0.3-0.30.6-0.3-0.40.4-0.9
Rest time, locomotor task time 13.44.35.4-2.2-2.3-2.1-2.0-2.0-1.92.2-1.9-1.91.9-2.3
Distance moved, locomotor task time 11.72.52.71.61.61.61.61.61.5-1.71.61.4-1.41.7
Vertical activity count, locomotor time 10.20.61.00.70.80.70.70.70.7-0.70.70.8-0.81.0
Time >=10cm from walls, locomotor time 21.82.63.31.51.31.61.71.71.7-1.51.81.8-1.81.4
Bouts of movement, locomotor time 21.01.62.01.41.41.31.31.31.3-1.21.21.2-1.21.2
Total resting periods, locomotor time 21.01.72.01.41.41.31.31.31.3-1.21.21.3-1.31.2
Rest time, locomotor task time 22.83.53.8-1.9-1.9-1.9-1.9-1.9-2.01.9-1.9-1.91.9-1.7
Distance moved, locomotor task time 22.53.04.01.71.51.81.91.91.8-1.72.01.8-1.81.1
Vertical activity count, locomotor time 22.43.34.11.81.71.81.91.91.8-1.81.92.0-2.01.3
Light reinforcement 10.00.10.20.30.30.30.30.30.3-0.40.30.4-0.4-0.0
Light reinforcement 20.50.81.4-1.0-1.2-0.8-0.8-0.8-0.90.8-0.6-0.80.8-1.1
Bone: marrow area0.00.10.1-0.2-0.2-0.3-0.3-0.3-0.30.2-0.3-0.20.2-0.1
Bone: maximum diameter0.20.50.70.60.50.70.70.70.6-0.70.70.7-0.70.8
Bone: maximum force0.71.21.61.21.31.11.11.11.0-1.21.01.0-1.01.2
Bone: maximum moment0.40.71.00.91.00.90.80.80.8-1.00.80.8-0.81.0
Mean time between licks in bursts0.20.50.7-0.5-0.4-0.7-0.7-0.7-0.70.7-0.8-0.80.8-0.5
Mean num. licks in bursts0.00.10.3-0.2-0.3-0.1-0.1-0.1-0.10.2-0.0-0.10.1-0.6
Cd content in liver1.61.82.61.21.11.41.51.51.2-1.41.61.2-1.21.3
Co content in liver1.01.21.6-1.1-1.1-1.1-1.1-1.1-1.01.1-1.1-1.11.1-1.3
Cu content in liver1.51.82.8-1.4-1.4-1.2-1.2-1.2-1.31.3-1.1-1.41.4-1.7
Fe content in liver0.10.10.5-0.2-0.2-0.1-0.1-0.1-0.20.1-0.0-0.20.2-0.7
K content in liver0.80.71.0-0.8-0.7-0.9-0.9-0.9-0.80.8-1.0-0.90.9-0.6
Mg content in liver0.20.20.2-0.4-0.4-0.4-0.4-0.4-0.40.4-0.4-0.50.5-0.3
Mn content in liver0.80.91.1-1.0-1.0-1.0-1.0-1.0-0.91.1-1.0-0.90.9-0.5
Na content in liver1.21.31.71.11.01.11.11.11.2-1.11.21.3-1.30.9
Rb content in liver1.41.72.2-1.3-1.4-1.2-1.2-1.2-1.31.3-1.1-1.31.3-1.5
Se content in liver4.24.95.4-2.2-2.1-2.2-2.3-2.3-2.32.1-2.3-2.32.3-2.1
Sr content in liver0.00.00.0-0.1-0.1-0.1-0.1-0.1-0.10.1-0.1-0.00.0-0.1
Zn content in liver0.00.00.1-0.1-0.2-0.00.10.0-0.10.10.1-0.30.3-0.3
Bone: minimum diameter1.52.72.91.61.61.71.71.71.6-1.71.71.7-1.71.5
Time in familiar zone, hab. session 11.11.11.2-1.1-1.1-1.0-1.0-1.0-1.11.0-1.0-1.11.1-1.0
Time in novel zone, hab. session 11.91.92.11.41.51.41.41.41.4-1.41.31.4-1.41.3
Total zone transitions, hab. session 12.12.94.21.71.81.61.61.61.7-1.61.51.8-1.82.0
Total locomotion distance, hab. session 10.50.71.60.91.10.80.70.70.8-0.80.60.8-0.81.3
Locomotion velocity, hab. session 10.40.61.60.81.00.60.60.60.7-0.70.50.7-0.71.3
Time in familiar zone, hab. session 20.20.20.3-0.5-0.4-0.5-0.5-0.5-0.40.4-0.5-0.40.40.2
Time in novel zone, hab. session 20.20.20.30.40.30.40.50.50.4-0.40.50.4-0.4-0.2
Total zone transitions, hab. session 20.50.60.80.70.70.80.80.80.8-0.70.80.8-0.80.9
Total locomotion distance, hab. session 20.40.50.6-0.7-0.6-0.7-0.7-0.7-0.70.7-0.7-0.80.8-0.2
Locomotion velocity, hab. session 20.20.30.4-0.6-0.5-0.6-0.6-0.6-0.60.6-0.7-0.70.7-0.0
Novel to familiar place preference ratio3.23.54.21.92.01.91.91.81.9-1.91.81.8-1.81.9
Novelty place preference3.53.84.42.02.12.01.91.92.0-1.91.91.9-1.92.0
Time in novel zone, NPP test2.93.13.61.81.91.81.81.81.8-1.81.71.7-1.71.7
Total zone transitions, NPP test1.62.32.5-1.6-1.5-1.6-1.6-1.5-1.51.6-1.5-1.51.5-1.2
Total locomotion distance, NPP test2.12.83.1-1.7-1.6-1.7-1.8-1.7-1.71.7-1.8-1.71.7-1.2
Locomotion velocity, NPP test1.72.52.7-1.6-1.5-1.6-1.6-1.6-1.61.6-1.6-1.61.6-1.1
Intraocular pressure0.40.50.7-0.7-0.7-0.8-0.8-0.8-0.70.8-0.8-0.70.7-0.4
Delta distance traveled before/after self-admin0.00.00.00.20.10.20.20.20.2-0.20.20.1-0.1-0.1
Delta ambulatory time before/after self-admin0.20.30.30.50.50.60.60.60.5-0.60.60.5-0.50.3
Parametrial fat weight0.00.00.2-0.2-0.2-0.1-0.1-0.1-0.20.1-0.0-0.20.2-0.4
Pavlov. Cond. lever latency0.50.60.8-0.8-0.7-0.8-0.8-0.8-0.80.6-0.8-0.90.9-0.4
Pavlov. Cond. magazine entry latency1.01.21.61.21.01.11.21.21.2-1.11.21.3-1.30.5
Pavlov. Cond. change in total contacts0.00.00.20.0-0.0-0.1-0.1-0.10.00.2-0.10.0-0.0-0.5
Pavlov. Cond. index score0.20.30.50.60.40.50.60.60.6-0.40.60.7-0.70.1
Pavlov. Cond. latency score0.30.40.60.70.50.60.70.70.7-0.50.70.8-0.80.2
Pavlov. Cond. lever contacts0.50.60.80.80.70.80.80.80.8-0.60.80.9-0.90.4
Pavlov. Cond. magazine entry number1.31.72.2-1.3-1.2-1.3-1.3-1.3-1.41.2-1.3-1.51.5-0.7
Pavlov. Cond. intertrial magazine entries0.10.10.70.20.30.20.20.20.2-0.30.20.2-0.20.8
Pavlov. Cond. lever-magazine prob. diff.0.20.20.40.50.30.40.40.40.5-0.30.40.6-0.6-0.1
Pavlov. Cond. response bias0.81.01.41.00.91.01.11.11.1-0.91.11.2-1.20.4
Pavlov. Cond. lever latency1.62.22.4-1.5-1.4-1.5-1.5-1.5-1.51.4-1.5-1.61.6-1.3
Pavlov. Cond. magazine entry latency1.01.31.51.11.11.11.11.11.2-1.01.11.2-1.21.2
Pavlov. Cond. change in total contacts0.40.60.70.70.70.80.80.80.8-0.70.80.8-0.80.8
Pavlov. Cond. index score2.02.72.91.61.61.61.61.61.7-1.61.61.7-1.71.5
Pavlov. Cond. latency score1.82.42.61.51.51.51.61.61.6-1.51.61.6-1.61.5
Pavlov. Cond. lever contacts2.53.53.81.81.81.91.91.91.9-1.81.92.0-2.01.7
Pavlov. Cond. magazine entry number1.31.62.2-1.2-1.2-1.2-1.2-1.2-1.31.2-1.2-1.21.2-1.5
Pavlov. Cond. intertrial magazine entries0.00.00.0-0.1-0.1-0.0-0.0-0.0-0.1-0.10.00.0-0.0-0.1
Pavlov. Cond. lever-magazine prob. diff.1.72.32.51.51.41.51.51.51.6-1.41.51.6-1.61.4
Pavlov. Cond. response bias2.63.63.81.91.81.91.91.92.0-1.81.91.9-1.91.7
Time in closed arm before self-admin5.46.97.32.72.72.72.72.72.7-2.62.72.7-2.72.1
Time in closed arm after self-admin3.43.64.72.12.21.91.81.82.0-2.01.72.0-2.01.4
Time in open arm before self-admin5.45.96.5-2.5-2.5-2.5-2.5-2.5-2.52.5-2.5-2.22.2-2.1
Time in open arm after self-admin5.96.57.1-2.6-2.5-2.5-2.6-2.6-2.62.5-2.5-2.72.7-2.3
Bone: periosteal estimation0.00.10.10.30.30.30.30.30.3-0.30.30.3-0.30.3
Bone: periosteal perimeter0.71.21.51.01.01.11.11.11.0-1.11.11.1-1.11.2
Bone: post-yield work0.00.00.10.00.1-0.1-0.1-0.1-0.00.0-0.10.0-0.00.4
Progressive ratio test 1 active lever presses1.82.22.51.61.51.51.61.61.5-1.51.61.2-1.21.5
Progressive ratio test 1 breakpoint1.72.02.41.51.41.51.51.51.5-1.51.51.1-1.11.4
Progressive ratio test 1 inactive lever presses2.33.34.51.92.01.81.81.81.8-1.91.81.4-1.42.1
Progressive ratio test 2 active lever presses6.17.18.02.82.82.82.82.82.7-2.82.72.3-2.32.6
Progressive ratio test 2 breakpoint6.27.18.12.82.82.82.82.82.7-2.82.72.3-2.32.6
Progressive ratio test 2 inactive lever presses5.38.69.63.13.13.03.03.02.9-3.03.02.7-2.72.8
Incentive Sensitization - Responses3.14.45.02.22.12.22.22.22.1-2.22.22.0-2.01.7
Incentive Sensitization - Breakpoint3.34.34.82.22.12.22.22.22.1-2.22.21.9-1.91.7
Sum of active levers in priming session hrs 5-63.12.84.7-1.7-1.9-1.6-1.5-1.5-1.71.5-1.4-1.71.7-2.2
Progressive ratio1.01.53.21.11.21.11.11.11.1-1.01.11.4-1.41.8
Food seeking constrained by brief footshock0.10.20.20.40.30.40.40.40.4-0.40.40.5-0.50.4
Seeking ratio, punishment vs. effort0.40.61.1-0.7-0.7-0.7-0.7-0.8-0.70.7-0.8-0.80.8-1.1
Retroperitoneal fat weight20.085.290.29.49.59.39.29.29.3-9.39.09.3-9.38.9
Reaction time number correct0.20.30.5-0.6-0.7-0.6-0.6-0.5-0.60.4-0.5-0.50.5-0.7
Reaction time mean minus median0.00.10.2-0.4-0.5-0.3-0.2-0.2-0.30.3-0.2-0.20.2-0.4
Reaction time mean minus median AUC0.00.00.1-0.3-0.4-0.2-0.1-0.1-0.20.2-0.0-0.20.2-0.4
Reaction time num false alarms2.02.83.2-1.7-1.6-1.7-1.8-1.8-1.81.5-1.8-1.81.8-0.9
Reaction time num false alarms AUC2.64.04.5-2.1-2.0-2.1-2.1-2.1-2.11.9-2.1-2.12.1-1.3
Reaction time trials correct on left0.20.30.5-0.6-0.7-0.6-0.6-0.5-0.60.4-0.5-0.50.5-0.7
Reaction time trials on left0.20.40.6-0.7-0.7-0.6-0.6-0.6-0.70.4-0.6-0.50.5-0.8
Reaction time mean0.10.20.50.40.30.50.60.60.5-0.40.70.4-0.40.2
Reaction time mean AUC0.30.40.80.50.40.70.80.80.7-0.60.90.6-0.60.3
Median of all reaction times0.40.50.90.70.50.80.90.90.7-0.71.00.6-0.60.4
Reaction time omissions0.20.40.4-0.6-0.6-0.6-0.6-0.6-0.60.6-0.6-0.60.6-0.7
Reaction time false alarm rate2.23.03.5-1.8-1.6-1.8-1.8-1.8-1.81.7-1.8-1.91.9-1.0
Reaction time premature initiation rate0.00.00.2-0.10.1-0.1-0.1-0.1-0.10.1-0.1-0.20.20.5
Reaction time premature initiations0.10.20.3-0.5-0.4-0.4-0.5-0.4-0.50.4-0.4-0.50.5-0.0
Std. dev. reaction times0.00.00.0-0.1-0.20.00.10.10.00.00.20.0-0.0-0.1
Reaction time trials completed0.20.40.6-0.7-0.7-0.6-0.6-0.6-0.70.4-0.6-0.50.5-0.8
Reaction time trials AUC0.10.20.4-0.5-0.6-0.4-0.4-0.4-0.50.3-0.4-0.40.4-0.6
Run reversals in cocaine runway, females2.12.12.41.51.51.51.51.51.5-1.31.51.4-1.41.4
Run reversals in cocaine runway, males0.10.10.2-0.00.0-0.2-0.2-0.2-0.10.2-0.3-0.40.4-0.1
Latency to leave start box in cocaine runway0.80.91.0-1.0-0.9-0.9-0.9-0.9-1.00.8-0.9-0.90.9-1.0
Latency to leave start box in cocaine runway, F0.50.60.8-0.9-0.9-0.8-0.8-0.8-0.90.7-0.8-0.60.6-0.8
Latency to leave start box in cocaine runway, M0.10.10.2-0.2-0.1-0.2-0.2-0.2-0.20.2-0.2-0.20.2-0.4
Std. dev. time between licks in bursts0.50.71.60.91.00.70.70.70.8-0.70.60.7-0.71.3
Total sessions with >9 infusions1.31.51.91.31.31.21.21.21.2-1.31.21.1-1.11.4
Short access day 1 total inactive lever presses1.51.93.91.41.41.41.31.31.3-1.41.31.1-1.12.0
Short access day 10 total inactive lever presses0.20.50.70.70.60.80.80.80.6-0.70.90.5-0.50.5
Short access day 1 total infusions2.83.73.91.91.81.92.02.02.0-1.92.01.9-1.92.0
Short access day 10 total infusions1.62.02.41.51.51.41.41.41.5-1.41.31.3-1.31.6
Short access total infusions1.51.92.11.41.31.41.41.41.4-1.41.41.3-1.31.4
Short access day 1 locomotion1.41.72.11.41.51.31.31.31.3-1.31.21.3-1.31.4
Short access day 10 total locomotion2.03.76.31.91.91.81.81.81.9-1.91.81.8-1.82.5
Short access total locomotion1.92.33.71.51.61.51.41.51.5-1.51.41.4-1.41.9
One hour access (0.3 mA shock)4.95.76.62.62.62.52.52.52.4-2.52.41.9-1.92.4
Compulsive drug intake3.13.74.0-2.0-2.0-2.0-2.0-2.0-1.92.0-2.0-1.91.9-1.3
One hour access (shock baseline)5.38.19.33.03.13.03.03.02.9-3.02.92.4-2.42.4
Social response proportion3.74.25.1-2.2-2.3-2.1-2.0-2.0-2.12.2-2.0-2.12.1-1.7
Social responses0.40.50.9-0.8-0.9-0.7-0.6-0.6-0.70.8-0.5-0.80.8-0.4
Social time6.18.49.9-3.0-3.2-2.9-2.9-2.8-2.92.9-2.8-2.92.9-2.6
Soleus weight0.30.91.8-0.8-0.8-0.9-0.9-1.0-0.90.9-1.0-0.70.7-1.3
Bone: stiffness1.21.92.71.41.41.41.31.31.3-1.41.31.3-1.31.7
Tibialis anterior weight1.65.36.6-2.2-2.2-2.3-2.3-2.3-2.32.3-2.3-2.22.2-2.6
Time to tail flick, vehicle, before self-admin0.40.40.70.60.60.60.60.60.6-0.70.60.6-0.60.8
Time to tail flick, vehicle, after self-admin3.34.44.72.12.22.12.12.12.1-2.12.12.0-2.02.1
Time to tail flick, test, before self-admin1.71.72.11.31.31.31.31.31.3-1.31.31.5-1.50.8
Time to tail flick, test, after self-admin2.62.73.41.51.61.61.61.61.6-1.61.61.8-1.81.5
Delta time to tail flick, vehicle, before/after SA1.21.21.41.21.21.11.11.11.1-1.01.01.1-1.11.0
Delta time to tail flick, test, before/after SA0.10.10.2-0.5-0.4-0.4-0.4-0.4-0.50.4-0.4-0.40.4-0.0
Tibia length0.20.51.6-0.7-0.9-0.6-0.5-0.6-0.70.7-0.5-0.60.6-1.3
Ambulatory time before self-admin0.00.00.10.20.20.10.10.10.1-0.30.10.3-0.3-0.3
Ambulatory time after self-admin0.81.01.31.00.91.01.01.01.0-1.11.01.0-1.00.3
Bone: tissue strength0.30.30.4-0.6-0.5-0.6-0.6-0.6-0.60.5-0.6-0.60.6-0.3
Total heroin consumption0.40.51.0-0.8-0.8-0.7-0.6-0.7-0.70.6-0.6-0.60.6-1.0
Bone: trabecular number0.50.91.21.01.00.90.90.91.0-0.70.81.1-1.10.8
Bone: trabecular spacing0.00.00.10.10.10.10.10.1-0.0-0.30.2-0.10.10.2
Bone: trabecular thickness0.50.60.80.80.70.80.80.80.8-0.70.80.9-0.90.6
Bone: trabecular tissue density0.30.50.6-0.8-0.8-0.7-0.7-0.7-0.70.6-0.7-0.60.6-0.7
Water consumed over 24 hours1.01.31.61.11.11.11.11.11.2-1.11.11.3-1.31.1
Number of responses in last shaping day5.35.86.32.52.52.52.52.52.5-2.42.52.1-2.12.3