Hub : Genes

Fndc4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc intron excision ratio chr6_30798871_30799166 0.02 0.02 4.4e-03 0.01 0.01 0.01 0.01 2.2e-03 3.0e-03 1.0e-02 2.7e-03
2 NAcc intron excision ratio chr6_30799290_30799513 0.02 0.02 3.2e-03 0.02 0.01 0.01 0.01 1.7e-03 2.3e-03 6.2e-03 2.3e-03
3 NAcc gene expression Fndc4 0.16 0.08 0.0e+00 0.24 0.24 0.24 0.24 7.1e-36 3.3e-36 3.1e-35 6.5e-36
4 RMTg gene expression Fndc4 0.24 0.16 3.1e-06 0.19 0.2 0.19 0.19 7.5e-06 6.7e-06 1.2e-05 1.2e-05
5 pVTA intron excision ratio chr6_30798871_30799166 0.31 0.2 1.0e-15 0.2 0.2 0.19 0.2 5.4e-16 3.9e-16 1.8e-15 2.2e-16
6 pVTA intron excision ratio chr6_30799290_30799513 0.33 0.28 2.1e-15 0.2 0.2 0.19 0.2 7.1e-16 9.8e-16 3.1e-15 3.7e-16
7 BLA gene expression Fndc4 0.17 0.18 6.4e-03 0.04 0.04 0.04 0.04 2.7e-03 3.9e-03 5.3e-03 4.8e-03
8 Adipose gene expression Fndc4 0.14 0.11 4.4e-12 0.09 0.1 0.1 0.09 1.6e-10 2.7e-11 9.0e-11 1.6e-10
9 Brain gene expression Fndc4 0.08 0.07 4.7e-07 0.06 0.06 0.06 0.06 2.5e-06 1.3e-06 6.6e-06 3.2e-06
10 pVTA gene expression Fndc4 0.03 0.03 9.0e-03 0.01 0.01 0.01 0.01 2.8e-02 2.6e-02 6.5e-02 4.9e-02
11 Liver gene expression Fndc4 0.03 0.03 4.1e-03 0.01 0.01 0.01 0.01 9.5e-03 1.4e-02 1.2e-02 1.7e-02
12 LHb intron excision ratio chr6_30798871_30799166 0.82 0.16 4.9e-10 0.32 0.27 0.32 0.33 2.3e-08 3.4e-07 2.9e-08 1.0e-08
13 LHb intron excision ratio chr6_30799290_30799513 0.74 0.24 9.9e-09 0.29 0.24 0.31 0.3 1.5e-07 1.6e-06 4.1e-08 8.4e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density4.38.09.1-3.03.0-3.03.03.0-3.0-2.8-3.0-3.03.02.9-2.0-2.0
Area under the delay curve0.20.31.0-0.20.2-0.40.40.3-0.3-0.3-0.6-0.60.71.0-0.5-0.9
BMI with tail0.20.81.40.8-0.81.0-0.9-0.90.91.20.90.9-0.9-0.70.80.6
BMI without tail0.31.92.61.4-1.41.4-1.4-1.31.31.61.41.4-1.4-1.31.31.1
Body weight2.08.710.73.1-3.13.1-3.1-3.03.03.33.03.0-3.0-2.82.62.3
Weight adjusted by age0.00.00.2-0.10.1-0.20.20.1-0.1-0.4-0.1-0.0-0.0-0.20.10.4
Bone surface2.44.75.8-2.42.4-2.32.32.3-2.3-2.2-2.3-2.32.32.1-1.3-1.3
Bone volume2.34.65.8-2.42.4-2.32.32.3-2.3-2.2-2.3-2.32.32.1-1.1-1.2
Breakpoint value in progressive ratio session0.50.91.6-0.70.7-1.01.00.9-0.9-1.2-1.0-1.11.11.3-0.6-0.7
Number of licking bursts0.00.10.3-0.30.3-0.30.30.3-0.3-0.1-0.3-0.40.40.5-0.1-0.3
Context. condit. distance diff. score0.00.00.0-0.00.0-0.00.0-0.0-0.0-0.0-0.0-0.00.00.0-0.1-0.1
Locomotion velocity, session 10.10.10.3-0.00.00.1-0.1-0.00.00.30.10.1-0.1-0.30.50.5
Locomotion distance, session 12.02.62.8-1.71.7-1.61.61.6-1.6-1.3-1.6-1.61.61.6-1.6-1.6
Locomotion velocity, session 20.20.20.50.5-0.50.5-0.5-0.50.50.70.50.4-0.4-0.4-0.0-0.1
Locomotion distance, session 20.00.00.1-0.10.1-0.10.00.1-0.10.0-0.0-0.00.0-0.1-0.3-0.2
Locomotion velocity, session 30.50.61.1-0.80.8-0.80.80.8-0.8-1.0-0.8-0.80.80.7-0.4-0.3
Locomotion distance, session 30.80.91.0-1.01.0-0.91.01.0-1.0-0.9-0.9-1.01.00.9-1.0-1.0
Stereotopy head waving bouts, day 31.72.02.6-1.41.4-1.51.51.5-1.5-1.6-1.4-1.41.41.4-1.2-1.1
Stereotopy head waving duration, day 30.10.10.3-0.30.3-0.30.30.3-0.3-0.5-0.3-0.30.30.3-0.10.0
Locomotion velocity, session 71.01.11.5-1.21.2-1.21.21.2-1.2-1.2-1.1-1.01.00.90.00.1
Locomotion distance, session 70.20.20.9-0.40.4-0.30.30.3-0.3-0.4-0.2-0.10.1-0.10.91.0
Stereotopy head waving bouts, day 70.10.10.6-0.10.1-0.10.10.1-0.10.1-0.1-0.20.20.2-0.8-0.7
Stereotopy head waving duration, day 70.40.51.9-0.50.5-0.60.60.5-0.5-0.5-0.6-0.60.60.6-1.4-1.3
Locomotion velocity, session 80.10.20.3-0.50.5-0.40.40.5-0.5-0.6-0.3-0.30.2-0.00.10.4
Locomotion distance, session 80.30.50.5-0.70.7-0.70.70.7-0.7-0.6-0.7-0.70.70.6-0.7-0.7
Degree of sensitization distance1.01.12.90.9-0.90.9-0.9-0.90.90.80.90.9-1.0-1.01.71.7
Degree of sensitization stereotypy0.20.20.40.5-0.50.5-0.5-0.50.50.70.40.4-0.3-0.3-0.5-0.5
Conditioned locomotion3.13.64.2-1.91.9-1.91.91.8-1.8-1.8-1.9-1.91.91.9-2.0-2.0
Cocaine response after cond. corrected0.71.11.9-0.90.9-1.01.00.9-0.9-0.8-1.1-1.11.11.3-1.2-1.4
Cocaine response after cond. not corrected1.62.33.2-1.41.4-1.41.51.4-1.4-1.2-1.5-1.61.61.8-1.5-1.7
Cocaine response before conditioning1.21.41.9-1.41.4-1.31.21.3-1.3-1.1-1.2-1.21.21.0-0.8-0.6
Saline control response0.50.71.0-1.01.0-0.90.90.9-0.9-0.9-0.8-0.80.80.7-0.8-0.6
Bone: connectivity density4.47.07.8-2.82.8-2.82.82.7-2.7-2.6-2.8-2.82.82.8-2.0-2.0
Bone: cortical apparent density0.50.81.1-0.80.8-0.80.90.8-0.8-0.7-0.9-0.91.01.0-0.9-1.0
Bone: cortical area0.61.01.4-1.21.2-1.11.11.1-1.1-0.9-1.1-1.11.11.00.0-0.2
Bone: cortical porosity1.11.21.8-1.11.1-1.11.11.1-1.1-1.1-1.0-1.01.00.9-1.3-1.2
Bone: cortical porosity1.21.31.5-1.21.2-1.21.11.2-1.2-1.2-1.1-1.11.11.0-1.2-1.1
Bone: cortical thickness0.00.00.1-0.20.2-0.10.10.1-0.10.2-0.1-0.10.20.10.30.1
Bone: cortical thickness1.41.82.0-1.41.4-1.41.41.4-1.4-1.4-1.4-1.41.41.3-1.0-1.0
Bone: cortical tissue density0.30.50.8-0.70.7-0.70.70.7-0.7-0.6-0.8-0.80.80.8-0.8-0.9
Condit. Reinf. active minus inactive responses0.60.71.20.8-0.80.8-0.8-0.80.80.80.80.7-0.7-0.61.10.9
Condit. Reinf. active-inactive response ratio0.70.81.20.9-0.90.9-0.9-0.90.90.80.80.8-0.8-0.61.10.9
Condit. Reinf. active responses0.20.20.5-0.40.4-0.50.50.4-0.4-0.3-0.5-0.60.60.7-0.2-0.4
Condit. Reinf. inactive responses1.62.12.4-1.51.5-1.51.51.5-1.5-1.2-1.5-1.51.51.5-1.4-1.4
Incentive salience index mean0.00.00.1-0.10.1-0.20.20.1-0.1-0.1-0.2-0.20.20.30.40.2
Condit. Reinf. lever presses0.71.01.4-1.01.0-1.01.01.0-1.0-0.9-1.1-1.11.11.2-0.7-0.8
Condit. Reinf. active minus inactive responses3.04.65.5-2.12.1-2.12.12.1-2.1-2.0-2.1-2.22.22.2-2.3-2.4
Condit. Reinf. active-inactive response ratio0.81.22.4-1.01.0-1.01.01.0-1.0-0.8-1.0-1.11.11.1-1.5-1.6
Condit. Reinf. active responses2.73.84.3-2.02.0-2.02.02.0-2.0-2.0-2.0-2.12.12.1-1.6-1.6
Condit. Reinf. inactive responses1.21.72.4-1.41.4-1.41.41.4-1.4-1.6-1.4-1.41.41.4-0.3-0.4
Condit. Reinf. lever presses1.92.83.1-1.61.6-1.71.71.6-1.6-1.7-1.7-1.71.71.8-1.6-1.7
Condit. Reinf. lever reinforcers received2.43.43.8-1.91.9-1.91.91.9-1.9-1.9-1.9-1.91.91.9-1.5-1.5
Conditioned reinforcement - actives0.31.13.3-1.21.2-1.11.11.2-1.2-1.8-0.9-0.80.70.4-1.0-0.4
Conditioned reinforcement - inactives1.33.74.3-2.02.0-2.12.01.9-1.9-1.9-2.0-1.91.91.7-1.9-1.5
Conditioned locomotion0.40.63.4-0.20.2-0.10.00.2-0.2-0.80.20.4-0.5-0.91.31.8
Patch foraging indifference point 0 sec0.31.02.90.7-0.70.8-0.8-0.90.90.70.90.8-0.8-0.91.71.6
Patch foraging indifference point AUC0.82.02.7-1.61.6-1.41.41.7-1.6-1.1-1.4-1.31.31.1-1.3-1.2
Delay disc. indifference point, 0s delay2.32.63.41.8-1.81.7-1.7-1.81.81.81.61.6-1.5-1.31.00.8
Delay disc. indifference point, 16s delay0.20.31.1-0.10.1-0.40.40.3-0.3-0.0-0.5-0.60.71.0-0.4-0.9
Delay disc. indifference point, 2s delay0.10.10.20.4-0.40.3-0.4-0.40.40.30.40.4-0.4-0.40.50.4
Delay disc. indifference point, 24s delay1.42.36.6-0.70.7-1.21.21.0-1.0-0.8-1.5-1.61.72.3-1.9-2.6
Delay disc. indifference point, 4s delay0.00.00.1-0.10.1-0.20.10.1-0.1-0.1-0.1-0.10.10.1-0.3-0.2
Delay disc. indifference point, 8s delay0.10.20.80.0-0.0-0.30.30.1-0.1-0.2-0.4-0.50.50.9-0.4-0.8
Indifference point function ln k0.00.00.1-0.00.0-0.00.0-0.10.1-0.40.00.1-0.1-0.10.00.1
Indifference point function log k0.00.00.1-0.00.0-0.00.0-0.10.1-0.40.00.1-0.1-0.10.00.1
Patch foraging total patch changes 0 sec0.30.92.60.7-0.70.8-0.8-0.80.80.60.80.8-0.8-0.81.61.5
Patch foraging total patch changes 12 sec1.11.42.41.1-1.11.2-1.1-1.11.11.11.11.1-1.1-1.21.61.5
Patch foraging total patch changes 18 sec0.10.20.90.1-0.10.3-0.3-0.10.10.20.30.4-0.4-0.60.80.9
Patch foraging total patch changes 24 sec0.51.62.91.1-1.11.2-1.2-1.11.11.01.21.3-1.3-1.51.61.7
Patch foraging total patch changes 6 sec0.10.20.30.4-0.40.4-0.4-0.30.30.50.40.4-0.4-0.40.60.5
Patch foraging time to switch 0 sec0.00.10.20.4-0.40.2-0.1-0.30.20.20.0-0.00.00.30.2-0.1
Patch foraging water rate 0 sec0.00.00.1-0.20.2-0.10.00.2-0.1-0.30.00.1-0.1-0.3-0.10.1
Patch foraging water rate 12 sec0.52.02.41.5-1.51.5-1.5-1.41.41.31.51.5-1.5-1.51.01.1
Patch foraging water rate 18 sec0.40.91.01.0-1.01.0-1.0-1.01.01.01.01.0-1.0-1.00.80.8
Patch foraging water rate 24 sec2.12.93.81.9-1.91.8-1.8-1.71.71.41.81.8-1.8-1.61.61.3
Patch foraging water rate 6 sec1.11.71.91.3-1.31.3-1.4-1.31.31.41.41.4-1.4-1.40.90.9
Seeking ratio, delayed vs. immediate footshock0.10.20.70.1-0.10.3-0.3-0.20.20.20.40.5-0.5-0.80.50.8
Distance traveled before self-admin0.00.00.30.0-0.00.1-0.00.1-0.10.2-0.0-0.00.00.1-0.4-0.6
Distance traveled after self-admin1.01.82.51.4-1.41.5-1.5-1.31.31.61.41.4-1.4-1.31.11.0
Extensor digitorum longus weight4.317.318.3-4.24.2-4.34.34.2-4.2-4.1-4.3-4.34.34.3-3.7-3.7
Bone: elastic displacement0.70.81.7-0.70.7-0.80.80.7-0.7-1.1-0.8-0.80.80.9-1.3-1.3
Bone: elastic work1.01.31.5-1.11.1-1.11.11.0-1.0-1.2-1.1-1.21.21.2-1.1-1.1
Bone: endosteal estimation0.61.41.9-1.31.3-1.31.31.3-1.3-1.4-1.2-1.21.21.1-0.2-0.2
Bone: endosteal perimeter0.20.60.8-0.80.8-0.80.80.8-0.8-0.9-0.8-0.80.80.8-0.0-0.1
Epididymis fat weight11.356.961.17.8-7.87.7-7.7-7.77.77.17.67.6-7.6-7.57.26.9
Delta time in closed arm before/after self-admin0.00.00.0-0.10.1-0.10.10.2-0.2-0.2-0.1-0.10.10.2-0.1-0.2
Delta time in open arm before/after self-admin0.10.10.1-0.30.3-0.30.30.2-0.2-0.4-0.3-0.30.30.30.10.1
Diff in mean of infusions in LGA sessions0.00.00.20.0-0.0-0.10.10.2-0.2-0.4-0.1-0.10.1-0.10.30.4
Delay discount exponential model param0.50.71.70.5-0.50.7-0.7-0.60.60.60.90.9-1.0-1.30.71.1
Extinction: sum of active levers before priming0.30.50.9-0.40.4-0.60.70.6-0.6-0.6-0.7-0.80.80.9-0.6-0.9
Active lever presses in extinction session 60.30.31.0-0.50.5-0.60.60.7-0.7-1.0-0.5-0.40.40.30.20.3
Bone: final force0.20.20.6-0.50.5-0.40.50.5-0.5-0.5-0.4-0.40.40.40.80.6
Bone: final moment0.20.30.6-0.60.6-0.50.50.5-0.5-0.5-0.5-0.50.50.50.70.5
Food consumed during 24 hour testing period0.10.20.3-0.60.6-0.50.50.5-0.5-0.3-0.5-0.50.50.4-0.3-0.3
Glucose0.30.40.90.5-0.50.6-0.6-0.50.50.60.70.7-0.7-0.80.80.9
Heart weight2.94.76.21.9-1.92.1-2.1-2.02.02.52.22.2-2.2-2.32.32.3
Delay discount hyperbolic model param0.30.41.00.4-0.40.6-0.6-0.40.40.40.70.7-0.8-1.00.40.7
Intermittent access intake day 1-15 change0.00.20.8-0.30.3-0.10.10.5-0.5-0.30.00.2-0.2-0.50.60.9
Intermittent access intake escalation0.00.21.0-0.00.00.1-0.20.3-0.30.00.30.4-0.4-0.70.71.0
Intermittent access intake escalation 20.20.32.0-0.20.20.1-0.10.4-0.30.20.20.3-0.3-0.81.11.4
Intermitt. access day 1 inactive lever presses0.11.21.8-1.31.3-1.21.21.1-1.1-1.3-1.1-1.01.00.8-0.9-0.5
Intermitt. access day 15 inactive lever presses1.26.79.9-3.13.1-2.82.72.8-2.8-2.5-2.5-2.52.41.8-2.3-1.7
Intermitt. access escalation Index0.10.41.10.4-0.40.6-0.5-0.30.30.80.60.6-0.6-0.81.11.0
Intermittent access day 1 total infusions1.44.35.0-2.12.1-2.22.22.0-2.0-2.2-2.1-2.12.12.0-2.0-1.8
Intermittent access day 15 total infusions0.61.62.4-1.41.4-1.41.31.5-1.5-1.4-1.2-1.21.10.8-0.8-0.5
Intermittent access terminal intake (last 3 days)1.32.23.1-1.71.7-1.61.61.8-1.7-1.6-1.5-1.41.41.1-1.0-0.7
Intermittent access total infusions1.61.93.1-1.41.4-1.51.41.4-1.3-1.7-1.4-1.31.31.2-1.4-1.2
Intermittent access day 1 locomotion1.01.92.2-1.31.3-1.51.51.3-1.3-1.4-1.5-1.51.51.5-1.1-1.2
Intermittent access day 15 total locomotion0.00.10.4-0.50.5-0.50.40.4-0.4-0.6-0.3-0.30.20.0-0.10.2
Intermittent access total locomotion0.10.10.6-0.30.3-0.40.40.3-0.3-0.8-0.3-0.30.30.2-0.20.0
Intermittent access standard deviation0.21.11.7-1.21.2-1.21.21.1-1.1-1.3-1.1-1.01.00.8-0.7-0.4
Left kidney weight0.00.00.10.4-0.40.2-0.2-0.20.20.20.10.1-0.1-0.1-0.0-0.1
Right kidney weight0.21.62.81.6-1.61.4-1.3-1.41.41.71.21.1-1.1-0.80.80.4
Cocaine induced anxiety0.10.20.4-0.60.6-0.50.50.7-0.6-0.5-0.5-0.50.40.20.10.3
Post-drug Anxiety1.01.21.61.2-1.21.1-1.1-1.11.11.21.11.1-1.1-1.10.80.8
Baseline Anxiety2.03.34.52.0-2.02.0-2.0-2.12.11.91.91.9-1.8-1.61.00.9
Tail length0.31.92.21.4-1.41.4-1.4-1.21.21.31.41.4-1.4-1.51.31.3
Length with tail1.98.49.43.1-3.12.9-3.0-2.92.92.72.93.0-3.0-3.02.72.6
Length without tail0.42.12.31.4-1.41.4-1.5-1.51.51.21.51.5-1.5-1.51.41.3
Times rat made contact with spout2.22.53.1-1.51.5-1.61.61.5-1.5-1.5-1.6-1.71.71.8-1.4-1.5
Lifetime Intake1.62.03.6-1.51.5-1.61.51.4-1.4-1.9-1.4-1.31.31.1-1.3-1.0
Liver weight, left3.76.47.02.5-2.52.5-2.5-2.62.62.62.52.5-2.5-2.52.52.4
Liver weight, right10.318.019.74.2-4.24.2-4.2-4.24.24.44.24.2-4.2-4.24.24.1
Locomotor activity0.20.30.50.7-0.70.5-0.6-0.70.70.60.50.4-0.4-0.10.50.3
Locomotor testing distance0.10.30.7-0.40.4-0.50.50.4-0.4-0.6-0.6-0.60.60.8-0.4-0.6
Locomotor testing rearing0.20.82.3-0.80.8-0.90.90.8-0.8-1.5-0.9-0.90.81.0-0.4-0.5
Locomotion in novel chamber0.50.62.40.4-0.40.7-0.6-0.60.60.20.70.7-0.8-0.71.51.5
Locomotion in novel chamber post-restriction1.54.56.02.4-2.42.3-2.2-2.32.32.02.12.1-2.1-1.71.91.6
Fecal boli incidents, locomotor time 10.20.51.4-0.60.6-0.50.60.6-0.6-0.4-0.6-0.60.60.6-1.1-1.2
Change in fecal boli incidents, locomotor task3.74.04.42.1-2.12.0-2.1-2.12.11.92.12.0-2.0-1.91.71.7
Time >=10cm from walls, locomotor time 10.10.10.70.3-0.30.2-0.2-0.30.30.30.10.0-0.00.2-0.5-0.8
Bouts of movement, locomotor time 11.92.53.1-1.61.6-1.51.51.5-1.5-1.3-1.6-1.61.61.7-1.5-1.8
Total resting periods, locomotor time 12.32.73.0-1.71.7-1.61.61.6-1.7-1.4-1.6-1.61.61.7-1.6-1.7
Rest time, locomotor task time 10.10.10.30.2-0.20.3-0.2-0.20.20.30.30.3-0.3-0.30.50.5
Distance moved, locomotor task time 10.41.11.51.2-1.21.1-1.1-1.11.11.11.01.0-0.9-0.91.10.9
Vertical activity count, locomotor time 10.10.40.60.7-0.70.6-0.7-0.70.70.70.60.6-0.5-0.40.30.1
Time >=10cm from walls, locomotor time 20.10.20.3-0.50.5-0.40.40.4-0.4-0.6-0.4-0.30.30.10.20.3
Bouts of movement, locomotor time 20.00.10.30.1-0.10.2-0.1-0.20.10.40.10.1-0.1-0.1-0.4-0.5
Total resting periods, locomotor time 20.00.10.5-0.20.2-0.20.20.2-0.20.0-0.2-0.10.10.1-0.7-0.7
Rest time, locomotor task time 21.01.61.8-1.31.3-1.31.31.3-1.3-1.0-1.3-1.31.31.3-1.2-1.2
Distance moved, locomotor task time 21.31.73.71.2-1.21.1-1.2-1.21.21.01.21.2-1.2-1.31.91.9
Vertical activity count, locomotor time 20.30.81.30.8-0.80.8-0.9-0.80.80.60.90.9-1.0-1.11.01.1
Light reinforcement 11.57.08.2-2.92.9-2.82.82.8-2.8-2.4-2.8-2.82.82.7-1.8-1.8
Light reinforcement 22.14.75.5-2.32.3-2.32.32.3-2.3-1.9-2.2-2.32.32.1-1.8-1.8
Bone: marrow area0.61.41.9-1.31.3-1.31.31.3-1.3-1.4-1.2-1.21.21.1-0.2-0.3
Bone: maximum diameter1.12.22.8-1.71.7-1.61.61.6-1.6-1.5-1.6-1.61.61.5-0.5-0.7
Bone: maximum force0.20.30.4-0.60.6-0.50.60.6-0.6-0.6-0.5-0.50.50.50.60.5
Bone: maximum moment0.20.40.6-0.80.8-0.70.70.7-0.7-0.7-0.6-0.60.60.60.50.4
Mean time between licks in bursts0.63.53.91.9-1.91.9-2.0-1.91.92.01.91.9-1.9-1.91.51.5
Mean num. licks in bursts0.10.10.2-0.40.4-0.40.40.4-0.4-0.4-0.4-0.40.40.3-0.4-0.4
Cd content in liver0.00.00.0-0.00.0-0.10.10.1-0.1-0.1-0.1-0.10.10.1-0.2-0.2
Co content in liver6.27.37.8-2.82.8-2.72.82.8-2.8-2.7-2.8-2.82.82.8-2.3-2.4
Cu content in liver0.10.10.1-0.30.3-0.30.30.3-0.3-0.3-0.3-0.30.30.3-0.2-0.2
Fe content in liver0.60.71.3-1.01.0-0.90.90.9-0.9-1.2-0.8-0.80.80.7-0.4-0.2
K content in liver0.50.50.7-0.90.9-0.70.70.8-0.8-0.4-0.7-0.70.70.6-0.4-0.5
Mg content in liver0.50.60.8-0.90.9-0.80.80.8-0.8-0.5-0.8-0.80.80.8-0.3-0.4
Mn content in liver0.10.10.2-0.30.3-0.30.30.3-0.3-0.5-0.2-0.20.20.20.10.1
Na content in liver0.40.40.7-0.80.8-0.70.70.8-0.8-0.6-0.7-0.70.70.5-0.4-0.3
Rb content in liver0.00.00.0-0.10.1-0.10.10.1-0.1-0.0-0.1-0.10.10.2-0.0-0.1
Se content in liver0.30.31.10.4-0.40.4-0.4-0.30.40.20.50.5-0.6-0.70.91.0
Sr content in liver0.10.10.20.4-0.40.4-0.3-0.40.40.50.30.3-0.3-0.20.30.2
Zn content in liver0.70.91.30.8-0.80.9-0.9-0.80.80.90.90.9-1.0-1.01.11.1
Bone: minimum diameter0.10.31.80.1-0.10.1-0.1-0.10.10.10.20.2-0.2-0.21.31.3
Time in familiar zone, hab. session 10.70.71.30.7-0.70.8-0.8-0.70.70.70.80.9-0.9-1.01.11.1
Time in novel zone, hab. session 10.60.70.90.9-0.90.9-0.9-0.90.90.50.90.9-0.9-0.80.70.8
Total zone transitions, hab. session 10.10.20.2-0.40.4-0.40.40.4-0.4-0.5-0.4-0.40.40.4-0.3-0.3
Total locomotion distance, hab. session 10.10.20.3-0.50.5-0.50.50.5-0.5-0.6-0.5-0.40.40.4-0.2-0.1
Locomotion velocity, hab. session 11.11.51.7-1.31.3-1.31.31.3-1.3-1.2-1.3-1.31.31.2-1.0-1.0
Time in familiar zone, hab. session 20.00.00.2-0.10.1-0.10.10.1-0.1-0.2-0.1-0.00.0-0.10.40.4
Time in novel zone, hab. session 20.40.50.70.8-0.80.8-0.8-0.80.80.70.70.7-0.7-0.50.40.3
Total zone transitions, hab. session 20.20.20.4-0.40.4-0.40.40.4-0.4-0.3-0.4-0.50.50.5-0.5-0.6
Total locomotion distance, hab. session 20.30.40.9-0.60.6-0.50.60.6-0.6-0.3-0.6-0.60.60.6-0.9-0.9
Locomotion velocity, hab. session 20.50.71.5-0.80.8-0.80.80.8-0.8-0.5-0.8-0.80.80.8-1.2-1.2
Novel to familiar place preference ratio0.70.91.31.1-1.11.0-1.0-1.01.01.11.00.9-0.9-0.80.20.1
Novelty place preference1.11.41.91.4-1.41.3-1.3-1.31.31.41.21.2-1.2-1.10.50.4
Time in novel zone, NPP test1.41.72.21.5-1.51.4-1.4-1.51.41.51.41.4-1.3-1.20.70.6
Total zone transitions, NPP test1.62.32.6-1.51.5-1.51.51.5-1.5-1.3-1.5-1.51.61.5-1.6-1.6
Total locomotion distance, NPP test2.12.93.7-1.71.7-1.71.71.7-1.7-1.5-1.7-1.71.71.6-1.9-1.8
Locomotion velocity, NPP test3.65.16.5-2.22.2-2.22.22.2-2.2-2.0-2.2-2.32.32.2-2.5-2.5
Intraocular pressure4.47.28.92.9-2.92.8-2.8-3.03.02.82.72.6-2.6-2.32.31.9
Delta distance traveled before/after self-admin1.82.03.21.1-1.11.4-1.4-1.31.31.31.41.4-1.5-1.51.81.8
Delta ambulatory time before/after self-admin0.20.31.10.2-0.20.4-0.4-0.30.30.40.40.5-0.5-0.51.11.0
Parametrial fat weight10.725.230.94.8-4.85.1-5.1-4.94.95.65.15.1-5.0-5.15.04.8
Pavlov. Cond. lever latency1.72.22.61.6-1.61.6-1.6-1.61.61.31.51.6-1.6-1.51.11.0
Pavlov. Cond. magazine entry latency0.10.10.2-0.40.4-0.30.30.4-0.4-0.2-0.3-0.30.30.3-0.4-0.4
Pavlov. Cond. change in total contacts0.00.00.1-0.30.3-0.20.20.2-0.2-0.1-0.2-0.20.20.2-0.1-0.1
Pavlov. Cond. index score0.81.01.2-1.11.1-1.01.01.1-1.1-0.8-1.0-1.01.00.9-0.8-0.8
Pavlov. Cond. latency score0.70.91.2-1.11.1-1.01.01.1-1.1-0.8-1.0-1.01.00.9-0.7-0.6
Pavlov. Cond. lever contacts1.21.41.7-1.31.3-1.31.21.3-1.3-1.1-1.2-1.31.31.2-0.9-0.9
Pavlov. Cond. magazine entry number0.50.60.80.9-0.90.8-0.8-0.90.90.60.80.8-0.8-0.70.60.6
Pavlov. Cond. intertrial magazine entries1.11.41.8-1.21.2-1.21.21.2-1.2-1.1-1.3-1.31.31.4-0.7-0.8
Pavlov. Cond. lever-magazine prob. diff.1.51.92.1-1.41.4-1.41.41.4-1.4-1.2-1.4-1.41.41.4-1.3-1.3
Pavlov. Cond. response bias1.41.82.0-1.41.4-1.41.31.4-1.4-1.1-1.3-1.41.41.3-1.3-1.2
Pavlov. Cond. lever latency1.42.02.51.3-1.31.4-1.4-1.41.41.61.41.4-1.4-1.41.41.5
Pavlov. Cond. magazine entry latency0.20.30.6-0.60.6-0.60.50.6-0.6-0.8-0.5-0.40.40.20.00.2
Pavlov. Cond. change in total contacts0.51.32.4-0.90.9-1.01.00.9-0.9-1.3-1.0-1.01.01.1-1.5-1.5
Pavlov. Cond. index score0.91.42.3-1.21.2-1.21.21.2-1.2-1.5-1.2-1.21.11.1-1.1-1.0
Pavlov. Cond. latency score0.91.52.4-1.21.2-1.31.21.2-1.2-1.6-1.2-1.21.11.0-1.1-1.0
Pavlov. Cond. lever contacts1.01.51.9-1.11.1-1.21.21.1-1.1-1.4-1.2-1.21.21.3-1.3-1.4
Pavlov. Cond. magazine entry number0.10.20.50.5-0.50.5-0.4-0.50.50.70.40.4-0.4-0.20.0-0.0
Pavlov. Cond. intertrial magazine entries2.45.26.12.4-2.42.3-2.3-2.42.42.52.22.2-2.2-2.02.22.0
Pavlov. Cond. lever-magazine prob. diff.0.61.01.7-1.01.0-1.01.01.0-1.0-1.3-1.0-0.90.90.8-0.8-0.7
Pavlov. Cond. response bias1.62.32.7-1.51.5-1.51.51.5-1.5-1.6-1.5-1.51.51.5-1.4-1.4
Time in closed arm before self-admin0.81.42.61.1-1.11.0-1.0-1.21.20.71.11.1-1.1-1.21.61.6
Time in closed arm after self-admin1.61.83.01.3-1.31.3-1.3-1.31.30.81.31.3-1.3-1.31.71.7
Time in open arm before self-admin0.30.41.5-0.20.2-0.30.40.4-0.40.0-0.4-0.50.50.7-1.1-1.2
Time in open arm after self-admin1.51.71.9-1.31.3-1.31.31.4-1.4-1.0-1.3-1.41.41.4-1.1-1.2
Bone: periosteal estimation0.92.22.9-1.71.7-1.61.61.6-1.6-1.5-1.6-1.61.61.5-0.3-0.5
Bone: periosteal perimeter0.40.91.0-1.01.0-1.01.01.0-1.0-0.9-1.0-1.01.01.0-0.2-0.3
Bone: post-yield work0.61.11.6-1.11.1-1.11.11.1-1.1-1.3-1.1-1.11.01.0-0.4-0.5
Progressive ratio test 1 active lever presses0.61.12.1-1.01.0-1.21.20.9-0.9-1.4-1.1-1.11.11.0-0.9-0.7
Progressive ratio test 1 breakpoint0.71.22.1-1.01.0-1.21.20.9-0.9-1.4-1.1-1.11.11.1-1.0-0.8
Progressive ratio test 1 inactive lever presses1.33.34.7-1.91.9-1.91.81.8-1.8-2.1-1.7-1.61.61.3-2.2-1.6
Progressive ratio test 2 active lever presses0.10.10.4-0.30.3-0.30.30.3-0.3-0.6-0.2-0.10.1-0.10.20.5
Progressive ratio test 2 breakpoint0.10.10.3-0.20.2-0.20.20.3-0.2-0.5-0.1-0.0-0.0-0.20.20.5
Progressive ratio test 2 inactive lever presses0.41.22.5-1.41.4-1.31.21.3-1.2-1.6-1.0-0.90.80.3-0.50.1
Incentive Sensitization - Responses0.00.10.3-0.40.4-0.20.20.5-0.5-0.3-0.1-0.10.0-0.20.40.6
Incentive Sensitization - Breakpoint0.10.10.6-0.30.3-0.10.10.4-0.4-0.20.00.1-0.1-0.40.60.8
Sum of active levers in priming session hrs 5-60.80.81.4-0.80.8-0.80.80.8-0.8-0.4-0.9-1.01.01.2-0.7-0.9
Progressive ratio0.10.20.80.0-0.00.2-0.3-0.30.4-0.00.40.4-0.5-0.80.50.9
Food seeking constrained by brief footshock2.73.35.3-2.02.0-1.91.81.9-1.9-2.3-1.7-1.61.61.2-2.0-1.3
Seeking ratio, punishment vs. effort0.40.92.1-0.60.6-0.70.80.9-0.9-0.6-0.8-0.90.91.0-1.4-1.4
Retroperitoneal fat weight21.294.796.49.7-9.79.8-9.8-9.89.89.69.89.8-9.8-9.89.79.6
Reaction time number correct0.31.11.3-1.01.0-1.01.01.0-1.0-0.8-1.0-1.01.01.1-1.1-1.1
Reaction time mean minus median0.00.00.10.1-0.10.1-0.1-0.10.1-0.00.20.2-0.2-0.3-0.00.1
Reaction time mean minus median AUC0.00.10.10.3-0.30.3-0.3-0.40.40.30.30.3-0.3-0.4-0.00.1
Reaction time num false alarms0.00.10.2-0.10.1-0.20.10.0-0.00.1-0.2-0.30.30.5-0.3-0.5
Reaction time num false alarms AUC0.00.10.4-0.10.1-0.20.20.1-0.10.1-0.3-0.40.50.6-0.3-0.5
Reaction time trials correct on left0.31.11.3-1.01.0-1.01.01.0-1.0-0.8-1.0-1.01.01.1-1.1-1.1
Reaction time trials on left0.31.11.4-1.11.1-1.01.01.1-1.1-0.9-1.0-1.11.11.1-1.2-1.2
Reaction time mean0.81.92.11.3-1.31.3-1.4-1.41.41.51.41.3-1.3-1.41.41.4
Reaction time mean AUC0.61.61.91.2-1.21.2-1.2-1.31.31.41.21.2-1.2-1.21.31.3
Median of all reaction times1.32.02.51.4-1.41.4-1.4-1.41.41.61.41.4-1.4-1.41.61.5
Reaction time omissions0.00.10.1-0.30.3-0.30.30.3-0.3-0.2-0.3-0.30.30.2-0.2-0.1
Reaction time false alarm rate0.10.10.20.4-0.40.3-0.3-0.40.40.50.20.1-0.10.10.30.1
Reaction time premature initiation rate0.10.20.30.6-0.60.5-0.5-0.50.50.50.50.5-0.5-0.4-0.3-0.2
Reaction time premature initiations0.00.21.0-0.00.0-0.10.10.1-0.10.0-0.1-0.10.10.2-1.0-0.9
Std. dev. reaction times0.20.61.00.7-0.70.7-0.7-0.70.70.70.80.8-0.8-0.90.91.0
Reaction time trials completed0.31.11.4-1.11.1-1.01.01.1-1.1-0.9-1.0-1.11.11.1-1.2-1.2
Reaction time trials AUC0.41.31.5-1.21.2-1.11.11.2-1.2-0.9-1.1-1.21.21.2-1.2-1.2
Run reversals in cocaine runway, females0.10.20.90.3-0.30.2-0.2-0.20.20.30.20.1-0.1-0.1-0.9-0.9
Run reversals in cocaine runway, males0.50.63.3-0.00.0-0.20.20.1-0.1-0.3-0.3-0.40.40.8-1.6-1.8
Latency to leave start box in cocaine runway0.30.50.8-0.70.7-0.70.70.9-0.9-0.9-0.7-0.70.60.5-0.3-0.2
Latency to leave start box in cocaine runway, F0.20.30.4-0.40.4-0.50.50.7-0.7-0.5-0.6-0.60.60.6-0.3-0.3
Latency to leave start box in cocaine runway, M0.00.00.2-0.20.2-0.10.10.1-0.1-0.40.00.1-0.2-0.40.00.2
Std. dev. time between licks in bursts0.10.10.30.1-0.10.2-0.2-0.20.20.50.20.2-0.2-0.30.50.5
Total sessions with >9 infusions0.30.41.6-0.80.8-0.70.70.6-0.6-1.3-0.6-0.50.40.3-0.4-0.1
Short access day 1 total inactive lever presses4.69.111.8-3.23.2-3.13.13.0-3.0-2.9-2.9-2.92.92.5-3.4-3.0
Short access day 10 total inactive lever presses0.64.35.9-2.22.2-2.12.12.0-2.0-1.9-2.0-2.02.11.9-2.4-2.2
Short access day 1 total infusions1.73.36.7-2.12.1-2.01.91.9-1.9-2.6-1.7-1.61.51.2-1.5-1.0
Short access day 10 total infusions1.32.22.8-1.51.5-1.51.51.3-1.3-1.7-1.5-1.41.41.4-1.7-1.5
Short access total infusions0.50.82.1-1.11.1-1.00.90.8-0.8-1.4-0.8-0.70.70.5-0.6-0.3
Short access day 1 locomotion1.42.24.5-1.61.6-1.61.61.5-1.5-2.1-1.5-1.41.31.1-1.3-0.9
Short access day 10 total locomotion0.41.71.9-1.31.3-1.41.41.2-1.2-1.3-1.3-1.31.31.3-1.2-1.1
Short access total locomotion0.00.10.3-0.30.3-0.30.30.1-0.1-0.6-0.2-0.10.10.00.00.1
One hour access (0.3 mA shock)0.70.81.5-1.21.2-1.01.01.0-1.0-1.2-0.9-0.80.80.5-0.4-0.1
Compulsive drug intake0.40.61.50.8-0.80.8-0.8-0.80.81.20.60.5-0.4-0.2-0.7-1.0
One hour access (shock baseline)0.61.52.7-1.51.5-1.41.41.4-1.4-1.6-1.2-1.21.10.9-0.4-0.1
Social response proportion0.60.72.30.6-0.60.6-0.7-0.60.70.50.70.8-0.8-0.91.31.5
Social responses0.20.21.10.3-0.30.3-0.3-0.30.30.50.40.4-0.4-0.50.81.0
Social time0.71.13.20.7-0.70.8-0.8-0.70.70.41.01.1-1.1-1.51.31.8
Soleus weight5.014.816.6-3.73.7-3.83.83.8-3.8-3.6-3.9-3.94.04.1-3.8-4.0
Bone: stiffness0.00.10.4-0.20.2-0.20.20.2-0.2-0.1-0.2-0.10.20.10.60.5
Tibialis anterior weight3.612.513.7-3.63.6-3.73.73.6-3.6-3.5-3.7-3.73.73.7-2.8-2.9
Time to tail flick, vehicle, before self-admin1.21.41.81.3-1.31.2-1.2-1.21.20.81.31.3-1.3-1.30.81.0
Time to tail flick, vehicle, after self-admin2.44.95.72.3-2.32.3-2.3-2.42.41.82.32.3-2.3-2.31.91.9
Time to tail flick, test, before self-admin0.10.10.3-0.00.0-0.20.20.1-0.1-0.2-0.2-0.20.20.3-0.6-0.6
Time to tail flick, test, after self-admin0.10.10.2-0.10.1-0.30.20.2-0.2-0.4-0.2-0.20.20.30.40.4
Delta time to tail flick, vehicle, before/after SA0.10.10.70.2-0.20.2-0.2-0.30.30.10.20.2-0.2-0.20.80.7
Delta time to tail flick, test, before/after SA1.21.41.7-1.31.3-1.31.31.3-1.3-1.2-1.3-1.31.31.2-0.6-0.5
Tibia length2.98.111.32.6-2.62.7-2.7-2.72.72.82.82.8-2.8-2.93.43.3
Ambulatory time before self-admin0.00.10.6-0.10.1-0.10.10.2-0.20.1-0.2-0.20.20.2-0.6-0.7
Ambulatory time after self-admin0.71.11.91.0-1.01.2-1.1-0.90.91.41.11.1-1.1-1.11.00.8
Bone: tissue strength0.80.81.21.0-1.01.0-0.9-1.01.01.10.90.8-0.8-0.61.00.7
Total heroin consumption3.03.64.8-1.71.7-2.02.02.0-2.0-1.8-2.0-2.02.12.2-1.3-1.5
Bone: trabecular number3.26.06.6-2.62.6-2.52.52.5-2.5-2.3-2.5-2.62.62.5-2.0-2.0
Bone: trabecular spacing2.63.84.92.2-2.22.1-2.1-2.12.12.22.02.0-1.9-1.81.31.0
Bone: trabecular thickness0.70.91.3-1.11.1-1.11.01.1-1.1-1.1-1.0-1.01.00.90.10.2
Bone: trabecular tissue density0.20.40.6-0.80.8-0.70.70.8-0.8-0.4-0.6-0.60.60.5-0.5-0.5
Water consumed over 24 hours0.40.81.0-1.01.0-0.90.90.9-0.9-0.6-0.9-1.01.01.0-0.4-0.5
Number of responses in last shaping day0.10.10.5-0.20.2-0.20.20.3-0.3-0.7-0.00.1-0.2-0.5-0.20.3