Tcf7l2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	intron excision ratio	chr1_264792701_264865777	0.03	0.03	1.3e-03	0.02	0.02	0.02	0.02	9.7e-04	2.0e-03	1.7e-03	9.0e-04
2	LHb	mRNA stability	Tcf7l2	0.19	0.12	1.5e-03	0.09	0.1	0.1	0.1	3.1e-03	2.1e-03	2.4e-03	2.0e-03
3	pVTA	gene expression	Tcf7l2	0.07	0.07	5.0e-03	0.04	0.03	0.03	0.03	5.8e-04	2.4e-03	1.5e-03	1.2e-03
4	Brain	mRNA stability	Tcf7l2	0.03	0.02	6.1e-03	0.03	0.02	0.02	0.02	1.6e-03	3.3e-03	5.2e-03	3.2e-03
5	pVTA	intron excision ratio	chr1_264792346_264792577	0.04	0.04	5.5e-03	0.03	0.02	0.03	0.03	1.1e-03	6.2e-03	3.1e-03	3.6e-03
6	Liver	gene expression	Tcf7l2	0.03	0.02	2.1e-03	0.02	0.01	0.02	0.02	1.2e-03	1.8e-02	1.4e-03	2.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	1.0	1.7	3.7	-1.9	1.5	1.9	0.6	-0.5	0.4
Area under the delay curve	0.5	0.6	1.9	-0.9	0.5	1.4	-0.4	0.4	-0.4
BMI with tail	8.2	28.4	49.4	-7.0	6.6	1.9	5.4	-4.8	4.6
BMI without tail	5.0	15.4	25.8	-5.1	4.6	1.0	4.3	-3.7	3.5
Body weight	8.6	37.5	68.6	-8.3	7.8	2.8	5.7	-5.3	5.2
Weight adjusted by age	4.1	6.2	8.9	-3.0	2.9	-0.3	2.4	-2.7	2.5
Bone surface	0.5	0.9	2.0	-1.4	1.0	0.8	0.9	-0.9	0.5
Bone volume	2.0	3.5	7.2	-2.7	2.3	1.6	1.4	-1.5	1.3
Breakpoint value in progressive ratio session	0.7	0.8	2.7	-0.9	0.2	1.6	-0.5	0.7	-0.7
Number of licking bursts	0.4	0.7	2.7	-1.0	0.2	1.7	-0.3	0.2	-0.5
Context. condit. distance diff. score	0.5	0.6	2.3	0.5	-0.3	-1.5	0.4	-0.5	0.4
Locomotion velocity, session 1	2.3	2.5	3.6	1.7	-1.9	0.4	-1.4	1.7	-1.8
Locomotion distance, session 1	0.3	0.3	1.0	0.8	-0.5	-1.0	0.3	-0.1	0.1
Locomotion velocity, session 2	1.0	1.2	3.9	1.2	-0.5	-2.0	0.8	-0.6	0.6
Locomotion distance, session 2	1.2	1.7	2.5	-1.5	1.6	0.3	1.3	-1.3	1.5
Locomotion velocity, session 3	0.2	0.2	0.7	0.1	0.1	-0.8	0.6	-0.4	0.4
Locomotion distance, session 3	1.2	1.3	2.5	-0.1	0.7	-1.6	1.4	-1.1	1.4
Stereotopy head waving bouts, day 3	0.0	0.0	0.1	-0.3	0.3	0.3	-0.1	-0.0	0.1
Stereotopy head waving duration, day 3	0.9	1.0	1.5	0.8	-1.2	0.5	-1.2	1.0	-1.2
Locomotion velocity, session 7	0.0	0.0	0.1	-0.1	0.1	0.2	0.4	-0.1	0.1
Locomotion distance, session 7	0.2	0.2	0.7	0.3	-0.1	-0.8	0.5	-0.3	0.5
Stereotopy head waving bouts, day 7	0.0	0.0	0.1	-0.4	0.1	0.3	0.1	-0.1	-0.1
Stereotopy head waving duration, day 7	0.3	0.3	0.8	-0.9	0.3	0.9	0.2	-0.3	-0.1
Locomotion velocity, session 8	0.9	1.1	2.7	1.7	-1.3	-1.1	-0.6	0.6	-0.6
Locomotion distance, session 8	0.4	0.6	1.9	0.4	-0.0	-1.4	0.7	-0.7	0.7
Degree of sensitization distance	1.4	1.5	2.2	0.8	-1.3	1.1	-1.3	1.3	-1.5
Degree of sensitization stereotypy	0.1	0.1	0.6	-0.5	0.1	0.8	-0.1	0.1	-0.3
Conditioned locomotion	0.1	0.1	0.3	0.3	0.0	-0.5	-0.1	-0.2	0.2
Cocaine response after cond. corrected	0.7	0.9	2.5	1.3	-0.9	-1.6	-0.4	0.2	-0.1
Cocaine response after cond. not corrected	1.4	1.6	3.5	1.9	-1.5	-1.5	-0.8	0.7	-0.7
Cocaine response before conditioning	0.8	0.9	1.6	0.8	-1.1	0.4	-0.9	1.1	-1.2
Saline control response	0.6	0.7	1.8	1.3	-1.0	-0.9	-0.5	0.6	-0.6
Bone: connectivity density	0.0	0.1	0.1	0.2	-0.2	0.3	-0.1	0.2	-0.4
Bone: cortical apparent density	2.0	2.8	10.7	1.8	-0.9	-3.3	0.9	-0.8	0.7
Bone: cortical area	5.0	7.6	16.1	-4.0	3.0	2.3	2.5	-2.4	1.8
Bone: cortical porosity	0.3	0.3	0.7	0.1	-0.1	0.8	-0.6	0.5	-0.5
Bone: cortical porosity	0.5	0.5	2.3	-0.4	0.3	1.5	-0.4	0.5	-0.4
Bone: cortical thickness	2.9	4.7	7.6	-2.8	2.5	1.0	2.3	-2.2	1.9
Bone: cortical thickness	2.6	3.1	5.0	-1.8	1.8	-0.3	2.2	-1.9	1.9
Bone: cortical tissue density	2.1	2.8	10.7	2.0	-1.0	-3.3	0.7	-0.7	0.6
Condit. Reinf. active minus inactive responses	0.2	0.2	0.4	0.4	-0.5	0.3	-0.3	0.4	-0.7
Condit. Reinf. active-inactive response ratio	0.5	0.5	1.0	0.7	-0.9	0.1	-0.5	0.7	-1.0
Condit. Reinf. active responses	0.2	0.2	1.0	-0.4	0.2	1.0	-0.1	0.2	-0.3
Condit. Reinf. inactive responses	0.4	0.5	1.8	-0.9	0.7	1.3	0.1	0.1	0.0
Incentive salience index mean	0.7	0.8	1.2	1.1	-1.1	0.2	-0.7	1.0	-1.1
Condit. Reinf. lever presses	0.9	1.2	1.9	1.3	-1.1	0.3	-0.9	1.4	-1.2
Condit. Reinf. active minus inactive responses	2.1	2.7	6.2	-0.5	-1.2	2.5	-1.3	1.3	-2.2
Condit. Reinf. active-inactive response ratio	1.6	1.8	3.5	0.0	-1.4	1.6	-1.2	1.2	-1.9
Condit. Reinf. active responses	1.8	2.5	8.3	-1.1	-0.5	2.9	-0.9	1.0	-1.8
Condit. Reinf. inactive responses	0.5	0.6	2.4	-0.7	0.3	1.6	-0.2	0.4	-0.5
Condit. Reinf. lever presses	1.0	1.4	4.7	-0.6	-0.5	2.2	-0.5	0.9	-1.5
Condit. Reinf. lever reinforcers received	1.7	2.4	7.7	-0.9	-0.6	2.8	-0.9	1.1	-1.9
Conditioned reinforcement - actives	0.4	0.7	1.6	0.0	-0.3	1.3	-1.1	0.8	-0.9
Conditioned reinforcement - inactives	0.3	0.5	1.6	-0.8	0.6	1.3	-0.5	0.1	-0.3
Conditioned locomotion	0.0	0.0	0.2	0.1	0.2	0.0	-0.1	-0.4	0.2
Patch foraging indifference point 0 sec	1.7	3.2	5.9	-2.4	2.4	1.2	1.4	-1.4	1.6
Patch foraging indifference point AUC	1.0	1.4	4.6	-0.4	0.1	2.1	-1.3	1.1	-1.0
Delay disc. indifference point, 0s delay	0.7	0.7	1.6	-1.3	1.2	0.6	0.5	-0.6	0.7
Delay disc. indifference point, 16s delay	0.6	0.6	1.5	-0.2	-0.2	1.2	-0.8	0.9	-0.9
Delay disc. indifference point, 2s delay	0.0	0.0	0.0	-0.2	0.2	-0.0	0.1	-0.1	0.2
Delay disc. indifference point, 24s delay	1.3	1.4	4.4	-0.8	0.1	2.1	-1.0	1.1	-1.1
Delay disc. indifference point, 4s delay	0.2	0.2	0.7	-0.2	0.0	0.8	-0.5	0.4	-0.4
Delay disc. indifference point, 8s delay	1.3	1.5	3.7	-1.9	1.4	1.9	0.1	0.0	0.0
Indifference point function ln k	0.3	0.6	2.2	0.5	-0.4	-1.5	0.7	-0.5	0.3
Indifference point function log k	0.3	0.6	2.2	0.5	-0.4	-1.5	0.7	-0.5	0.3
Patch foraging total patch changes 0 sec	1.6	2.9	5.7	-2.4	2.3	1.4	1.2	-1.2	1.4
Patch foraging total patch changes 12 sec	0.7	0.9	3.5	-1.1	0.9	1.9	-0.2	0.1	0.0
Patch foraging total patch changes 18 sec	1.6	2.5	8.8	-2.0	1.5	3.0	-0.4	0.2	-0.1
Patch foraging total patch changes 24 sec	1.2	2.0	7.9	-1.1	0.8	2.8	-0.8	0.9	-0.9
Patch foraging total patch changes 6 sec	2.5	3.8	8.4	-2.9	2.4	2.2	1.1	-1.1	1.2
Patch foraging time to switch 0 sec	0.2	0.4	1.1	1.1	-0.8	-0.9	-0.1	0.0	-0.2
Patch foraging water rate 0 sec	0.2	0.4	1.0	-1.0	0.9	0.3	0.5	-0.4	0.5
Patch foraging water rate 12 sec	0.3	0.6	1.8	-1.3	1.0	0.7	0.4	-0.3	0.4
Patch foraging water rate 18 sec	0.6	1.0	1.5	-1.2	1.0	-0.4	1.2	-0.9	0.9
Patch foraging water rate 24 sec	1.7	2.3	5.4	-2.3	1.8	0.3	1.6	-1.3	1.1
Patch foraging water rate 6 sec	0.7	0.9	1.7	-0.8	0.7	-0.8	1.3	-1.1	0.9
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.1	0.3	-0.2	-0.1	-0.1	-0.1	-0.0
Distance traveled before self-admin	1.9	2.4	7.4	0.8	0.2	-2.7	1.5	-1.4	1.5
Distance traveled after self-admin	1.5	1.9	2.8	-0.2	0.9	-1.6	1.5	-1.6	1.7
Extensor digitorum longus weight	0.3	1.0	2.2	-1.3	1.5	1.1	0.3	-0.5	0.8
Bone: elastic displacement	0.0	0.0	0.2	-0.0	0.2	0.4	-0.1	0.2	-0.1
Bone: elastic work	1.9	2.5	3.9	-1.2	1.7	-0.7	2.0	-1.7	1.9
Bone: endosteal estimation	1.3	2.8	6.7	-2.6	1.9	1.6	1.3	-1.2	0.9
Bone: endosteal perimeter	2.7	5.7	12.3	-3.5	2.3	1.5	2.5	-2.4	1.5
Epididymis fat weight	6.3	21.6	48.3	-7.0	5.8	4.0	3.7	-3.2	2.8
Delta time in closed arm before/after self-admin	0.5	0.5	0.9	-0.1	0.4	-0.8	0.5	-0.9	1.0
Delta time in open arm before/after self-admin	0.7	0.7	2.0	-1.0	0.4	1.4	-0.3	0.6	-0.6
Diff in mean of infusions in LGA sessions	0.8	0.9	1.8	1.2	-1.4	-0.5	-0.8	0.8	-0.8
Delay discount exponential model param	0.6	0.7	2.2	0.9	-0.5	-1.5	0.4	-0.4	0.4
Extinction: sum of active levers before priming	1.4	1.6	2.4	0.3	-1.0	1.4	-1.4	1.5	-1.5
Active lever presses in extinction session 6	0.1	0.1	0.4	-0.6	0.3	0.6	0.1	-0.1	-0.0
Bone: final force	1.4	2.3	4.4	-2.1	1.5	0.8	1.7	-1.5	1.1
Bone: final moment	1.8	2.9	5.6	-2.4	1.8	1.0	1.8	-1.6	1.3
Food consumed during 24 hour testing period	0.2	0.3	0.5	-0.3	0.2	-0.7	0.5	-0.7	0.6
Glucose	1.9	2.9	4.0	-1.4	1.8	-0.6	2.0	-2.0	2.0
Heart weight	1.8	2.8	4.7	-2.2	2.0	1.0	1.7	-1.6	1.2
Delay discount hyperbolic model param	0.4	0.5	1.5	0.9	-0.6	-1.2	0.3	-0.3	0.2
Intermittent access intake day 1-15 change	0.8	1.7	3.6	-1.9	1.6	-0.0	1.6	-0.8	0.9
Intermittent access intake escalation	0.7	1.5	3.5	-1.9	1.6	0.2	1.3	-0.6	0.9
Intermittent access intake escalation 2	0.7	0.8	1.7	-1.3	1.1	-0.1	1.1	-0.4	0.6
Intermitt. access day 1 inactive lever presses	0.5	1.8	5.5	-1.9	1.3	2.3	-0.2	0.3	-0.2
Intermitt. access day 15 inactive lever presses	0.1	0.3	1.1	-0.4	0.2	1.0	-0.4	0.3	-0.5
Intermitt. access escalation Index	0.2	0.3	0.6	-0.3	0.5	-0.5	0.4	-0.6	0.8
Intermittent access day 1 total infusions	0.4	0.6	2.1	-0.7	0.2	1.5	-0.7	0.5	-0.6
Intermittent access day 15 total infusions	0.4	0.5	1.5	-1.2	0.8	1.0	0.0	0.1	-0.0
Intermittent access terminal intake (last 3 days)	0.2	0.2	0.7	-0.8	0.5	0.5	0.0	0.0	0.0
Intermittent access total infusions	0.5	0.6	1.9	-1.1	0.6	1.4	-0.4	0.3	-0.2
Intermittent access day 1 locomotion	0.3	0.4	0.8	-0.5	0.7	0.1	0.2	-0.9	0.8
Intermittent access day 15 total locomotion	0.9	1.6	3.6	-1.9	1.7	0.7	0.9	-1.0	0.9
Intermittent access total locomotion	0.9	1.1	1.5	-0.9	1.1	-0.6	1.2	-1.2	1.1
Intermittent access standard deviation	0.3	0.6	1.8	-1.1	0.6	1.4	-0.2	0.3	-0.2
Left kidney weight	3.1	14.4	19.5	-3.6	4.4	-0.7	4.3	-4.2	4.2
Right kidney weight	4.1	18.5	25.7	-4.3	5.1	-0.5	4.9	-4.5	4.6
Cocaine induced anxiety	1.0	1.4	3.8	1.9	-1.4	-1.5	-0.6	0.3	-0.2
Post-drug Anxiety	0.0	0.0	0.0	0.2	-0.1	-0.1	-0.1	0.1	0.0
Baseline Anxiety	1.1	1.2	3.2	-1.8	1.1	1.7	0.3	0.2	-0.3
Tail length	0.2	0.7	1.4	-1.2	1.0	0.7	0.5	-0.6	0.8
Length with tail	1.3	5.7	10.0	-3.2	3.1	1.2	2.0	-2.1	2.2
Length without tail	3.1	10.1	19.7	-4.4	4.3	2.5	2.3	-2.3	2.4
Times rat made contact with spout	1.1	1.2	2.1	-1.3	1.5	0.4	0.9	-1.1	1.1
Lifetime Intake	0.6	0.7	2.0	-1.2	0.7	1.4	-0.2	0.3	-0.3
Liver weight, left	3.6	6.0	10.9	-3.3	2.9	1.6	2.7	-2.0	1.6
Liver weight, right	7.3	12.8	18.0	-4.1	4.2	0.3	3.8	-3.7	3.7
Locomotor activity	1.4	2.3	3.3	-1.3	1.3	-0.9	1.8	-1.8	1.7
Locomotor testing distance	2.1	3.8	5.8	-1.1	1.5	-1.7	2.3	-2.4	2.3
Locomotor testing rearing	1.2	2.4	4.0	-1.2	1.4	-1.0	2.0	-1.8	1.8
Locomotion in novel chamber	1.3	1.7	2.7	-0.0	0.7	-1.6	1.4	-1.6	1.6
Locomotion in novel chamber post-restriction	0.6	1.0	2.4	1.6	-1.2	-1.1	-0.5	0.6	-0.5
Fecal boli incidents, locomotor time 1	0.1	0.2	0.3	0.2	-0.3	0.4	-0.5	0.5	-0.5
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	0.4	-0.3	-0.3	-0.2	0.1	-0.0
Time >=10cm from walls, locomotor time 1	0.7	0.8	1.6	1.3	-1.2	-0.5	-0.7	0.8	-0.6
Bouts of movement, locomotor time 1	1.1	1.3	4.6	-1.4	0.6	2.1	-0.4	0.5	-0.5
Total resting periods, locomotor time 1	1.0	1.1	4.0	-1.4	0.7	2.0	-0.3	0.3	-0.4
Rest time, locomotor task time 1	0.3	0.4	0.8	-0.9	0.7	0.4	0.5	-0.6	0.6
Distance moved, locomotor task time 1	0.0	0.0	0.1	0.2	-0.0	-0.4	-0.0	0.1	-0.1
Vertical activity count, locomotor time 1	0.4	0.9	3.5	0.9	-0.2	-1.9	0.5	-0.5	0.5
Time >=10cm from walls, locomotor time 2	0.2	0.3	0.7	-0.8	0.6	0.8	-0.0	-0.1	0.2
Bouts of movement, locomotor time 2	0.3	0.5	1.0	1.0	-1.0	-0.3	-0.5	0.6	-0.6
Total resting periods, locomotor time 2	0.1	0.2	0.4	0.6	-0.7	-0.1	-0.4	0.4	-0.5
Rest time, locomotor task time 2	0.3	0.4	0.8	0.1	0.3	-0.9	0.7	-0.6	0.5
Distance moved, locomotor task time 2	0.6	0.7	1.8	-0.4	-0.1	1.3	-0.9	0.8	-0.7
Vertical activity count, locomotor time 2	0.1	0.1	0.3	-0.5	0.4	0.4	-0.1	-0.1	0.1
Light reinforcement 1	0.5	1.2	2.2	1.4	-1.5	-0.3	-0.9	0.9	-1.1
Light reinforcement 2	0.8	1.2	2.4	1.6	-1.6	-0.6	-0.8	0.6	-0.9
Bone: marrow area	1.3	2.9	6.9	-2.6	1.9	1.6	1.3	-1.2	0.9
Bone: maximum diameter	4.1	7.6	17.5	-4.2	2.9	2.7	2.2	-2.2	1.6
Bone: maximum force	1.1	1.9	3.5	-1.9	1.2	0.6	1.7	-1.4	1.0
Bone: maximum moment	1.3	2.3	4.3	-2.1	1.5	0.9	1.8	-1.4	1.1
Mean time between licks in bursts	0.2	0.4	1.2	-0.2	-0.2	1.1	-0.6	0.6	-0.7
Mean num. licks in bursts	1.1	1.7	2.9	-0.2	1.2	-1.5	1.3	-1.3	1.7
Cd content in liver	1.5	1.7	5.7	0.5	0.1	-2.4	1.0	-1.3	1.2
Co content in liver	0.8	0.9	3.1	1.3	-0.4	-1.8	0.1	0.1	0.5
Cu content in liver	0.1	0.1	0.3	0.5	-0.2	-0.6	0.2	-0.1	0.0
Fe content in liver	0.7	0.8	2.8	-0.9	0.7	1.7	-0.6	0.3	-0.2
K content in liver	0.7	0.6	1.2	1.1	-0.7	-0.1	-0.9	1.0	-0.7
Mg content in liver	0.4	0.4	0.7	0.6	-0.5	0.3	-0.6	0.7	-0.8
Mn content in liver	0.1	0.1	0.2	0.3	-0.4	-0.4	-0.2	0.0	-0.2
Na content in liver	1.3	1.4	2.2	1.2	-1.4	0.3	-1.2	1.2	-1.5
Rb content in liver	2.1	2.5	3.8	1.2	-1.5	0.8	-2.0	1.9	-1.7
Se content in liver	1.2	1.5	2.4	1.3	-1.5	-0.3	-1.1	1.2	-1.4
Sr content in liver	1.3	1.1	2.9	1.4	-1.2	-1.7	-0.4	0.4	-0.4
Zn content in liver	0.4	0.5	1.3	1.1	-0.5	-1.2	-0.3	0.3	0.0
Bone: minimum diameter	2.6	4.8	10.3	-3.2	2.4	2.1	1.7	-1.8	1.4
Time in familiar zone, hab. session 1	0.6	0.6	2.4	0.6	-0.4	-1.5	0.3	-0.5	0.4
Time in novel zone, hab. session 1	0.8	0.8	3.4	-1.1	0.4	1.8	-0.1	0.2	-0.5
Total zone transitions, hab. session 1	1.6	2.2	2.8	-1.6	1.7	0.1	1.6	-1.5	1.7
Total locomotion distance, hab. session 1	0.1	0.1	0.3	-0.5	0.2	0.6	0.1	-0.0	0.0
Locomotion velocity, hab. session 1	0.0	0.1	0.2	-0.3	0.2	0.5	-0.0	0.1	0.0
Time in familiar zone, hab. session 2	1.9	2.1	6.1	-2.1	1.3	2.5	-0.1	-0.2	0.1
Time in novel zone, hab. session 2	1.1	1.1	4.1	1.3	-0.6	-2.0	0.6	-0.3	0.4
Total zone transitions, hab. session 2	2.1	2.7	4.3	-1.9	2.1	0.3	1.6	-1.6	1.7
Total locomotion distance, hab. session 2	1.1	1.5	2.5	-1.5	1.6	0.4	1.1	-1.1	1.2
Locomotion velocity, hab. session 2	0.7	0.9	1.5	-1.2	1.2	0.2	1.0	-0.9	1.0
Novel to familiar place preference ratio	0.2	0.2	0.4	0.0	-0.3	0.6	-0.5	0.5	-0.5
Novelty place preference	0.2	0.2	0.6	-0.2	-0.2	0.7	-0.3	0.4	-0.4
Time in novel zone, NPP test	0.4	0.4	1.6	-0.6	0.1	1.3	-0.3	0.4	-0.4
Total zone transitions, NPP test	1.5	2.2	3.8	-1.9	1.9	1.0	1.3	-1.2	1.3
Total locomotion distance, NPP test	1.0	1.4	2.6	-1.6	1.6	1.1	0.8	-0.8	1.0
Locomotion velocity, NPP test	0.6	0.8	1.4	-1.1	1.2	0.3	0.9	-0.8	1.0
Intraocular pressure	2.1	3.0	6.9	-2.6	2.0	2.2	0.9	-0.9	0.7
Delta distance traveled before/after self-admin	0.7	0.7	1.8	-1.4	1.0	0.6	0.5	-0.7	0.6
Delta ambulatory time before/after self-admin	0.7	0.8	2.2	-1.5	0.9	1.4	0.1	-0.1	0.0
Parametrial fat weight	6.1	14.4	34.1	-5.8	4.5	4.1	2.6	-2.1	1.8
Pavlov. Cond. lever latency	0.3	0.4	1.1	-1.0	0.7	0.8	-0.2	-0.5	0.3
Pavlov. Cond. magazine entry latency	0.2	0.2	0.7	-0.4	0.9	0.4	0.4	-0.2	0.4
Pavlov. Cond. change in total contacts	0.2	0.2	0.4	0.2	0.3	-0.7	0.6	-0.4	0.4
Pavlov. Cond. index score	0.2	0.3	0.6	-0.1	0.7	-0.3	0.8	-0.3	0.6
Pavlov. Cond. latency score	0.2	0.2	0.5	0.0	0.5	-0.4	0.7	-0.3	0.5
Pavlov. Cond. lever contacts	0.4	0.4	1.1	1.1	-0.8	-0.5	-0.0	0.6	-0.5
Pavlov. Cond. magazine entry number	1.1	1.4	2.7	1.0	-1.6	0.1	-1.4	1.0	-1.4
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.4	-0.7	0.4	0.2	0.1	-0.3	0.3
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.3	-0.0	0.5	-0.2	0.6	-0.1	0.4
Pavlov. Cond. response bias	0.1	0.1	0.3	0.2	0.3	-0.4	0.6	-0.0	0.3
Pavlov. Cond. lever latency	1.5	2.0	6.0	0.4	0.6	-2.5	1.0	-1.4	1.7
Pavlov. Cond. magazine entry latency	0.9	1.1	2.8	-1.3	1.2	1.7	0.5	-0.1	0.0
Pavlov. Cond. change in total contacts	1.2	2.0	7.4	-0.9	0.0	2.7	-0.8	1.2	-1.3
Pavlov. Cond. index score	1.2	1.6	6.5	-1.2	0.4	2.6	-0.2	0.6	-1.0
Pavlov. Cond. latency score	1.2	1.5	6.3	-1.3	0.5	2.5	-0.1	0.6	-0.9
Pavlov. Cond. lever contacts	0.9	1.2	4.0	-0.5	-0.3	2.0	-0.5	0.9	-1.3
Pavlov. Cond. magazine entry number	0.8	1.0	3.0	1.3	-1.0	-1.7	-0.4	-0.1	0.1
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.5	-0.4	-0.1	-0.3	0.4	-0.7	0.3
Pavlov. Cond. lever-magazine prob. diff.	1.0	1.4	5.5	-1.2	0.5	2.4	-0.0	0.5	-0.8
Pavlov. Cond. response bias	1.0	1.4	5.4	-0.9	0.1	2.3	-0.4	0.9	-1.1
Time in closed arm before self-admin	0.1	0.1	0.2	0.3	-0.0	-0.5	0.3	0.0	-0.0
Time in closed arm after self-admin	0.2	0.2	0.6	0.7	-0.4	-0.8	0.0	-0.2	0.2
Time in open arm before self-admin	0.8	0.9	2.0	1.4	-1.2	-0.2	-0.9	0.7	-0.7
Time in open arm after self-admin	0.8	0.9	1.9	-0.1	-0.4	1.4	-1.0	1.1	-1.1
Bone: periosteal estimation	3.8	7.9	16.9	-4.1	3.2	2.2	2.5	-2.4	1.9
Bone: periosteal perimeter	5.6	9.6	20.6	-4.5	3.3	2.3	2.9	-2.8	2.2
Bone: post-yield work	0.5	0.8	1.9	-0.3	-0.6	1.4	-0.6	0.8	-1.1
Progressive ratio test 1 active lever presses	0.8	0.9	2.9	-1.3	0.7	1.7	-0.4	0.6	-0.4
Progressive ratio test 1 breakpoint	0.7	0.9	2.7	-1.2	0.6	1.6	-0.5	0.6	-0.4
Progressive ratio test 1 inactive lever presses	0.8	1.1	3.4	-1.0	0.3	1.8	-0.7	0.9	-0.9
Progressive ratio test 2 active lever presses	0.8	0.9	3.0	-1.7	1.2	1.1	0.3	-0.0	0.1
Progressive ratio test 2 breakpoint	0.9	1.0	3.2	-1.8	1.3	1.1	0.3	-0.1	0.2
Progressive ratio test 2 inactive lever presses	0.5	0.8	2.0	-1.4	0.7	1.4	0.0	0.3	-0.5
Incentive Sensitization - Responses	0.4	0.5	1.7	-1.3	0.9	0.5	0.5	-0.1	0.0
Incentive Sensitization - Breakpoint	0.3	0.4	1.4	-1.2	0.8	0.4	0.5	-0.1	-0.0
Sum of active levers in priming session hrs 5-6	0.8	0.7	1.1	0.9	-1.1	0.2	-0.8	0.9	-1.0
Progressive ratio	0.7	1.0	1.6	0.9	-1.1	0.7	-1.3	1.0	-1.1
Food seeking constrained by brief footshock	1.5	1.9	2.8	0.4	-1.1	1.5	-1.7	1.5	-1.6
Seeking ratio, punishment vs. effort	0.2	0.2	0.5	-0.7	0.6	-0.0	0.5	-0.4	0.4
Retroperitoneal fat weight	6.9	29.2	64.6	-8.0	6.8	4.8	4.3	-3.5	3.3
Reaction time number correct	0.5	0.9	2.2	-1.5	1.2	1.0	0.5	-0.3	0.5
Reaction time mean minus median	0.1	0.2	0.5	-0.7	0.4	0.4	0.3	-0.5	0.2
Reaction time mean minus median AUC	0.3	0.8	1.2	-0.8	0.8	-0.4	1.1	-1.1	0.9
Reaction time num false alarms	0.1	0.1	0.4	-0.0	-0.0	0.6	-0.3	0.4	-0.3
Reaction time num false alarms AUC	0.0	0.0	0.1	0.1	0.1	0.4	-0.1	0.3	-0.0
Reaction time trials correct on left	0.5	0.9	2.2	-1.5	1.2	1.0	0.5	-0.3	0.5
Reaction time trials on left	0.5	1.0	2.4	-1.6	1.2	1.0	0.5	-0.4	0.6
Reaction time mean	0.3	0.4	0.9	0.0	0.2	-0.9	0.7	-0.9	0.5
Reaction time mean AUC	0.2	0.2	0.8	0.5	-0.3	-0.9	0.3	-0.5	0.1
Median of all reaction times	0.5	0.7	2.0	0.3	0.1	-1.4	0.8	-1.0	0.6
Reaction time omissions	0.1	0.2	0.6	-0.8	0.3	0.6	0.3	-0.4	-0.0
Reaction time false alarm rate	0.3	0.3	0.6	0.8	-0.7	0.1	-0.6	0.6	-0.6
Reaction time premature initiation rate	1.0	1.4	2.1	-0.4	1.3	-1.1	1.3	-1.4	1.4
Reaction time premature initiations	1.5	2.7	4.1	-1.3	2.0	-0.6	1.7	-1.7	1.9
Std. dev. reaction times	0.5	1.0	1.5	-1.2	1.1	0.4	1.0	-1.1	0.8
Reaction time trials completed	0.5	1.0	2.4	-1.6	1.2	1.0	0.5	-0.4	0.6
Reaction time trials AUC	0.5	1.0	2.6	-1.6	1.3	1.1	0.5	-0.4	0.6
Run reversals in cocaine runway, females	1.2	1.2	1.7	-1.0	1.3	-0.2	1.0	-1.3	1.3
Run reversals in cocaine runway, males	1.1	1.1	1.8	1.1	-1.3	0.1	-1.0	1.1	-1.3
Latency to leave start box in cocaine runway	0.5	0.5	1.4	1.2	-1.0	-0.7	-0.4	0.3	-0.4
Latency to leave start box in cocaine runway, F	0.6	0.7	1.8	1.4	-1.0	-1.1	-0.2	0.2	-0.2
Latency to leave start box in cocaine runway, M	0.1	0.0	0.2	-0.2	0.1	0.5	-0.1	-0.0	-0.1
Std. dev. time between licks in bursts	1.2	1.6	3.1	-0.0	-0.8	1.7	-1.3	1.4	-1.6
Total sessions with >9 infusions	1.2	1.4	3.6	-1.9	1.6	0.9	0.8	-0.7	0.7
Short access day 1 total inactive lever presses	0.5	0.6	1.5	-1.2	0.8	1.2	-0.0	0.2	-0.1
Short access day 10 total inactive lever presses	0.2	0.6	1.2	-1.1	1.0	0.3	0.7	-0.7	0.6
Short access day 1 total infusions	0.2	0.2	0.7	-0.8	0.6	0.4	0.4	-0.0	0.0
Short access day 10 total infusions	0.2	0.3	0.6	-0.0	-0.3	0.7	-0.5	0.7	-0.7
Short access total infusions	0.2	0.3	0.7	-0.8	0.4	0.9	0.0	0.3	-0.3
Short access day 1 locomotion	0.3	0.4	1.2	-0.8	0.4	1.1	-0.2	0.3	-0.4
Short access day 10 total locomotion	1.4	2.6	3.8	-1.1	1.5	-1.1	1.9	-1.9	1.7
Short access total locomotion	0.9	1.1	1.5	-1.1	1.2	-0.2	1.0	-1.2	1.1
One hour access (0.3 mA shock)	2.2	2.6	7.0	-1.3	0.1	2.6	-1.1	1.6	-1.7
Compulsive drug intake	0.9	1.1	2.2	-0.2	-0.4	1.5	-0.9	1.2	-1.2
One hour access (shock baseline)	0.2	0.3	0.9	-1.0	0.7	0.6	0.1	-0.1	0.1
Social response proportion	3.9	4.4	6.7	-1.6	2.2	-1.2	2.6	-2.3	2.4
Social responses	2.2	2.9	5.8	-2.4	2.2	1.6	1.5	-0.9	1.1
Social time	1.2	1.7	2.7	-1.1	1.6	-0.2	1.6	-1.2	1.5
Soleus weight	4.3	12.8	19.1	-3.5	4.4	-0.3	3.8	-3.7	4.1
Bone: stiffness	0.3	0.5	1.6	-0.9	0.0	-0.0	1.2	-0.9	0.1
Tibialis anterior weight	0.3	0.9	1.8	0.4	-0.2	1.1	-1.4	1.2	-0.9
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.5	-0.6	0.7	0.0	0.5	-0.6	0.5
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.4	0.6	-0.7	-0.1	-0.3	0.4	-0.5
Time to tail flick, test, before self-admin	1.2	1.2	2.0	-0.0	0.8	-1.4	1.2	-1.3	1.2
Time to tail flick, test, after self-admin	0.3	0.4	1.4	-0.7	0.3	1.2	-0.1	0.3	-0.3
Delta time to tail flick, vehicle, before/after SA	0.7	0.6	1.0	0.4	-0.7	0.7	-0.8	1.0	-1.0
Delta time to tail flick, test, before/after SA	0.3	0.3	1.2	-0.4	-0.1	1.1	-0.5	0.5	-0.5
Tibia length	1.9	5.3	8.5	-2.4	2.2	-0.4	2.9	-2.7	2.2
Ambulatory time before self-admin	2.0	3.0	6.1	0.0	0.9	-2.5	2.0	-1.8	1.9
Ambulatory time after self-admin	2.2	2.6	4.0	-0.6	1.2	-1.8	2.0	-1.8	1.8
Bone: tissue strength	0.3	0.3	0.5	0.5	-0.5	0.2	-0.7	0.7	-0.7
Total heroin consumption	1.3	1.5	4.1	-2.0	1.6	1.4	0.5	-0.4	0.4
Bone: trabecular number	0.3	0.5	2.2	-0.7	0.3	1.5	-0.3	0.2	-0.4
Bone: trabecular spacing	0.2	0.2	0.3	0.6	-0.6	-0.1	-0.5	0.5	-0.3
Bone: trabecular thickness	3.1	3.9	8.1	-2.9	2.4	2.3	1.2	-1.1	1.2
Bone: trabecular tissue density	0.3	0.4	0.9	0.0	-0.3	-1.0	0.8	-0.7	0.3
Water consumed over 24 hours	1.1	1.4	2.5	-1.0	1.0	-0.8	1.4	-1.6	1.2
Number of responses in last shaping day	0.1	0.1	0.1	-0.3	0.3	0.4	-0.3	0.2	0.0