Tcf7l2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	intron excision ratio	chr1_254787414_254860496	0.03	0.03	1.4e-03	0.03	0.02	0.03	0.02	7.5e-04	2.4e-03	4.7e-04	1.1e-03
2	LHb	gene expression	Tcf7l2	0.12	0.09	1.0e-02	0.09	0.1	0.12	0.09	3.2e-03	2.5e-03	1.1e-03	3.4e-03
3	Liver	alternative polyA	XM_039090415.1	0.02	0.02	6.8e-03	0.02	0.01	0.01	-0	6.7e-03	2.8e-02	8.7e-03	5.6e-01
4	LHb	intron excision ratio	chr1_254973121_254976798	0.17	0.12	9.5e-03	0.09	0	0.06	0.04	4.6e-03	2.3e-01	1.5e-02	4.1e-02
5	Liver	gene expression	Tcf7l2	0.03	0.02	1.3e-03	0.02	0.01	0.02	0.01	1.2e-03	1.4e-02	6.5e-03	5.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	1.5	2.6	5.7	2.4	-1.7	-0.6	-1.9	-0.3
Area under the delay curve	0.9	1.0	2.1	1.2	-1.1	0.4	-1.5	0.3
BMI with tail	5.5	17.9	28.6	3.8	-5.3	-5.0	-1.4	-4.4
BMI without tail	2.8	5.7	11.6	2.4	-3.4	-2.5	-1.3	-1.8
Body weight	6.3	26.3	44.0	4.1	-6.6	-6.1	-1.6	-5.6
Weight adjusted by age	3.8	4.3	8.9	1.6	-3.0	-2.0	-0.0	-2.4
Bone surface	0.8	1.5	5.5	2.3	-0.4	-0.9	-0.8	-0.4
Bone volume	1.9	3.2	8.2	2.9	-1.2	-1.5	-1.7	-1.2
Breakpoint value in progressive ratio session	1.6	1.7	2.9	1.7	-1.1	0.9	-1.7	0.9
Number of licking bursts	1.5	1.8	5.4	2.3	-0.8	0.2	-1.6	0.5
Context. condit. distance diff. score	0.7	0.8	2.2	-0.9	0.9	-0.4	1.5	-0.5
Locomotion velocity, session 1	1.4	1.5	3.6	0.1	1.3	1.4	-0.4	1.9
Locomotion distance, session 1	0.3	0.4	0.9	-0.5	0.9	-0.2	1.0	0.1
Locomotion velocity, session 2	1.5	1.8	4.1	-1.6	1.1	-0.9	2.0	-0.5
Locomotion distance, session 2	0.7	1.0	1.6	0.6	-1.1	-1.2	-0.4	-1.3
Locomotion velocity, session 3	0.3	0.4	0.8	-0.4	0.6	-0.6	0.9	-0.5
Locomotion distance, session 3	1.3	1.4	2.5	-1.1	-0.1	-1.2	1.6	-1.4
Stereotopy head waving bouts, day 3	0.0	0.0	0.1	0.0	0.3	0.2	-0.3	-0.1
Stereotopy head waving duration, day 3	0.9	1.1	1.8	0.7	1.2	1.2	-0.4	1.4
Locomotion velocity, session 7	0.1	0.1	0.3	0.4	-0.6	-0.3	-0.2	0.1
Locomotion distance, session 7	0.2	0.2	0.5	-0.5	0.4	-0.4	0.7	-0.3
Stereotopy head waving bouts, day 7	0.3	0.4	1.6	1.3	0.1	0.1	-0.4	0.3
Stereotopy head waving duration, day 7	0.9	1.1	4.3	2.1	-0.5	-0.1	-0.8	0.2
Locomotion velocity, session 8	0.7	0.8	1.9	-1.4	0.7	0.6	1.1	0.6
Locomotion distance, session 8	0.5	0.7	1.9	-0.8	0.6	-0.7	1.4	-0.7
Degree of sensitization distance	1.3	1.3	2.6	0.9	0.6	1.2	-1.1	1.6
Degree of sensitization stereotypy	0.4	0.4	1.4	1.2	-0.5	0.1	-0.7	0.3
Conditioned locomotion	0.2	0.2	0.6	-0.8	0.2	0.2	0.5	-0.2
Cocaine response after cond. corrected	1.0	1.1	2.3	-1.5	1.0	0.5	1.4	0.2
Cocaine response after cond. not corrected	1.6	1.8	3.2	-1.8	1.6	0.9	1.4	0.8
Cocaine response before conditioning	0.6	0.8	1.5	-0.1	1.2	0.9	-0.5	1.2
Saline control response	0.4	0.5	1.6	-1.3	-0.5	0.2	0.7	0.1
Bone: connectivity density	0.1	0.1	0.3	0.5	-0.2	0.2	-0.3	0.5
Bone: cortical apparent density	2.9	3.9	9.7	-2.4	1.2	-1.2	3.1	-1.0
Bone: cortical area	6.9	10.3	27.4	5.2	-2.8	-2.9	-2.3	-1.7
Bone: cortical porosity	0.6	0.6	1.7	0.9	-0.2	0.4	-1.3	0.7
Bone: cortical porosity	0.8	0.9	2.6	0.9	-0.8	0.3	-1.6	0.5
Bone: cortical thickness	3.0	4.9	9.2	3.0	-2.2	-2.5	-1.0	-1.8
Bone: cortical thickness	1.9	2.3	4.6	1.2	-1.7	-2.1	0.3	-1.5
Bone: cortical tissue density	3.1	4.0	10.0	-2.5	1.4	-1.0	3.2	-0.9
Condit. Reinf. active minus inactive responses	0.2	0.3	0.6	0.5	0.8	0.2	-0.3	0.6
Condit. Reinf. active-inactive response ratio	0.5	0.5	1.4	0.5	1.2	0.4	-0.1	0.9
Condit. Reinf. active responses	0.3	0.3	1.0	0.7	-0.3	0.1	-1.0	0.2
Condit. Reinf. inactive responses	0.8	0.9	2.3	0.8	-1.5	0.1	-1.3	0.0
Incentive salience index mean	0.4	0.5	1.1	-0.1	0.9	0.6	-0.1	1.1
Condit. Reinf. lever presses	0.4	0.5	1.4	-0.4	0.4	0.8	-0.3	1.2
Condit. Reinf. active minus inactive responses	4.8	6.0	15.8	4.0	-0.2	1.2	-2.6	2.4
Condit. Reinf. active-inactive response ratio	3.7	3.8	10.1	3.2	0.6	1.1	-1.7	2.1
Condit. Reinf. active responses	4.5	6.3	16.8	4.1	-1.1	0.8	-3.0	1.9
Condit. Reinf. inactive responses	1.1	1.3	3.1	1.0	-1.8	0.1	-1.6	0.3
Condit. Reinf. lever presses	2.7	3.7	8.6	2.9	-1.3	0.7	-2.3	1.6
Condit. Reinf. lever reinforcers received	4.1	5.8	14.9	3.9	-1.0	0.9	-2.9	1.9
Conditioned reinforcement - actives	0.2	0.2	0.4	-0.4	-0.2	0.6	-0.3	0.4
Conditioned reinforcement - inactives	0.4	0.5	1.6	0.8	-1.2	-0.2	-0.6	0.1
Conditioned locomotion	0.2	0.2	0.5	-0.7	0.0	0.6	0.1	0.4
Patch foraging indifference point 0 sec	1.9	3.1	6.8	1.8	-2.6	-1.3	-1.3	-1.5
Patch foraging indifference point AUC	1.8	2.1	5.6	0.9	-1.2	1.3	-2.4	0.9
Delay disc. indifference point, 0s delay	0.5	0.5	0.9	0.8	-1.0	-0.5	-0.7	-0.6
Delay disc. indifference point, 16s delay	0.8	0.8	1.6	0.7	-0.4	1.0	-1.2	1.0
Delay disc. indifference point, 2s delay	0.0	0.0	0.1	-0.0	0.0	-0.1	-0.0	-0.3
Delay disc. indifference point, 24s delay	2.1	2.1	4.3	1.6	-1.1	1.1	-2.1	1.0
Delay disc. indifference point, 4s delay	0.3	0.3	0.7	0.3	-0.0	0.6	-0.8	0.5
Delay disc. indifference point, 8s delay	2.3	2.4	4.4	2.0	-2.1	-0.0	-1.9	-0.1
Indifference point function ln k	0.7	1.0	3.0	-0.4	0.9	-1.0	1.7	-0.5
Indifference point function log k	0.7	1.0	3.0	-0.4	0.9	-1.0	1.7	-0.5
Patch foraging total patch changes 0 sec	2.0	3.2	7.1	1.9	-2.7	-1.0	-1.6	-1.2
Patch foraging total patch changes 12 sec	1.5	2.0	4.8	1.3	-1.8	0.4	-2.2	0.2
Patch foraging total patch changes 18 sec	3.0	3.9	9.5	2.1	-2.3	0.4	-3.1	0.1
Patch foraging total patch changes 24 sec	2.7	3.4	9.9	1.6	-1.7	0.8	-3.2	0.9
Patch foraging total patch changes 6 sec	3.6	5.3	12.3	2.5	-3.5	-0.7	-2.5	-1.0
Patch foraging time to switch 0 sec	0.3	0.5	1.2	-0.9	1.1	0.2	0.7	0.3
Patch foraging water rate 0 sec	0.2	0.3	0.5	0.7	-0.5	-0.7	-0.1	-0.7
Patch foraging water rate 12 sec	0.4	0.7	1.3	1.0	-1.1	-0.4	-0.7	-0.5
Patch foraging water rate 18 sec	0.8	1.0	1.6	1.0	-1.3	-1.1	0.3	-1.0
Patch foraging water rate 24 sec	1.5	2.0	4.1	2.0	-1.3	-1.7	-0.2	-1.3
Patch foraging water rate 6 sec	0.6	0.9	2.0	0.7	-0.2	-1.4	0.9	-1.1
Seeking ratio, delayed vs. immediate footshock	0.0	0.1	0.2	-0.2	0.5	0.1	-0.1	0.0
Distance traveled before self-admin	2.4	2.6	4.8	-2.2	0.3	-1.2	2.2	-1.4
Distance traveled after self-admin	2.1	2.3	4.3	-1.2	-0.8	-1.7	1.6	-2.1
Extensor digitorum longus weight	0.3	1.3	3.4	0.6	-1.8	-0.5	-1.2	-1.0
Bone: elastic displacement	0.3	0.4	1.3	0.2	-1.2	0.4	-0.5	0.2
Bone: elastic work	1.4	1.9	3.2	0.4	-1.7	-1.8	0.6	-1.6
Bone: endosteal estimation	1.3	2.9	7.7	2.8	-1.3	-1.5	-1.5	-0.9
Bone: endosteal perimeter	3.4	7.1	20.7	4.5	-1.9	-2.7	-1.3	-1.3
Epididymis fat weight	8.7	20.3	36.2	4.8	-6.0	-4.6	-2.8	-3.7
Delta time in closed arm before/after self-admin	0.3	0.2	0.5	-0.6	0.1	-0.3	0.6	-0.7
Delta time in open arm before/after self-admin	1.2	1.1	2.3	1.5	-1.0	0.6	-1.2	0.8
Diff in mean of infusions in LGA sessions	0.8	0.9	2.1	-0.2	0.6	1.4	-0.0	1.5
Delay discount exponential model param	1.1	1.1	2.4	-1.2	1.2	-0.4	1.6	-0.3
Extinction: sum of active levers before priming	1.4	1.4	1.9	1.1	-0.6	1.4	-1.3	1.3
Active lever presses in extinction session 6	0.5	0.5	0.8	0.9	-0.9	-0.1	-0.8	0.1
Bone: final force	2.1	3.4	9.4	3.1	-1.3	-2.0	-0.8	-1.1
Bone: final moment	2.5	4.0	10.1	3.2	-1.6	-2.1	-1.0	-1.3
Food consumed during 24 hour testing period	0.3	0.3	0.4	0.6	0.7	-0.6	0.7	-0.3
Glucose	2.2	3.3	8.1	1.1	-1.2	-2.8	0.3	-2.5
Heart weight	2.1	2.9	5.6	2.0	-2.4	-1.7	-0.6	-1.3
Delay discount hyperbolic model param	0.6	0.7	1.5	-0.9	0.9	-0.3	1.2	-0.2
Intermittent access intake day 1-15 change	1.1	1.1	2.8	1.7	-1.0	-1.2	-0.3	-0.4
Intermittent access intake escalation	1.9	1.9	3.8	1.6	-1.4	-2.0	0.2	-1.1
Intermittent access intake escalation 2	1.2	1.2	2.9	1.1	-1.0	-1.7	0.5	-0.9
Intermitt. access day 1 inactive lever presses	1.7	1.8	4.9	1.5	-2.2	-0.4	-1.2	-0.0
Intermitt. access day 15 inactive lever presses	0.2	0.2	0.4	0.6	-0.6	-0.1	-0.4	0.4
Intermitt. access escalation Index	0.3	0.3	0.5	0.1	-0.7	-0.7	0.4	-0.5
Intermittent access day 1 total infusions	1.0	1.1	2.1	1.1	-0.6	1.0	-1.5	0.9
Intermittent access day 15 total infusions	1.1	1.2	3.4	1.8	-1.3	-0.4	-1.0	0.1
Intermittent access terminal intake (last 3 days)	0.6	0.7	2.1	1.4	-0.6	-0.1	-0.8	0.4
Intermittent access total infusions	1.0	1.1	2.4	1.5	-1.0	0.3	-1.3	0.5
Intermittent access day 1 locomotion	0.0	0.0	0.1	-0.3	-0.2	0.1	-0.0	-0.3
Intermittent access day 15 total locomotion	0.9	1.0	2.1	1.4	-1.2	-0.8	-0.6	-0.5
Intermittent access total locomotion	0.2	0.2	0.4	-0.1	-0.1	-0.6	0.5	-0.5
Intermittent access standard deviation	2.1	2.2	4.7	2.0	-1.1	0.6	-2.2	0.7
Left kidney weight	4.1	11.6	22.9	0.5	-3.5	-4.8	1.6	-4.5
Right kidney weight	4.1	11.5	23.6	1.5	-3.6	-4.9	1.1	-4.2
Cocaine induced anxiety	2.8	3.3	6.7	-2.6	2.2	0.4	2.2	-0.1
Post-drug Anxiety	0.5	0.5	1.1	-0.9	0.7	-0.1	1.0	-0.3
Baseline Anxiety	4.4	4.7	9.3	3.0	-2.8	-1.0	-2.2	-0.5
Tail length	0.3	0.8	1.9	1.0	-1.4	-0.3	-1.0	-0.0
Length with tail	1.5	5.5	10.1	1.8	-3.2	-2.7	-0.8	-2.5
Length without tail	3.3	7.1	12.1	1.6	-3.1	-3.3	-0.4	-3.5
Times rat made contact with spout	0.6	0.7	1.2	0.4	-1.1	-0.9	-0.4	-1.1
Lifetime Intake	1.1	1.3	2.9	1.7	-1.0	0.3	-1.4	0.6
Liver weight, left	2.3	3.7	6.6	2.2	-2.6	-1.4	-2.2	-0.7
Liver weight, right	4.6	7.6	12.0	2.4	-3.5	-3.2	-1.4	-2.8
Locomotor activity	1.0	1.5	3.0	0.6	-1.1	-1.7	0.8	-1.6
Locomotor testing distance	1.6	2.7	5.4	0.1	-1.0	-2.3	1.4	-2.3
Locomotor testing rearing	0.9	1.4	3.0	0.4	-1.1	-1.7	0.8	-1.4
Locomotion in novel chamber	0.9	1.1	2.2	-0.9	-0.4	-1.0	1.2	-1.5
Locomotion in novel chamber post-restriction	0.7	0.9	2.7	-1.6	0.4	0.4	1.2	0.1
Fecal boli incidents, locomotor time 1	0.1	0.1	0.3	0.2	0.2	0.5	-0.5	0.4
Change in fecal boli incidents, locomotor task	0.2	0.2	0.4	-0.5	0.7	0.1	0.2	0.1
Time >=10cm from walls, locomotor time 1	0.9	0.9	2.2	-1.1	1.5	0.7	0.4	0.6
Bouts of movement, locomotor time 1	2.4	2.7	5.4	2.3	-1.6	0.5	-2.2	0.6
Total resting periods, locomotor time 1	2.2	2.4	5.3	2.3	-1.5	0.4	-2.0	0.5
Rest time, locomotor task time 1	0.2	0.2	0.4	0.6	-0.4	-0.5	-0.1	-0.4
Distance moved, locomotor task time 1	0.1	0.1	0.2	-0.5	0.3	-0.0	0.3	-0.2
Vertical activity count, locomotor time 1	2.1	2.2	3.6	-1.9	1.7	-0.6	1.8	-0.8
Time >=10cm from walls, locomotor time 2	0.2	0.2	0.5	0.6	-0.3	-0.0	-0.7	-0.1
Bouts of movement, locomotor time 2	0.5	0.5	1.0	-0.6	1.0	0.8	0.2	0.8
Total resting periods, locomotor time 2	0.2	0.2	0.4	-0.2	0.6	0.6	0.0	0.7
Rest time, locomotor task time 2	0.4	0.4	0.8	-0.7	-0.3	-0.6	0.9	-0.6
Distance moved, locomotor task time 2	0.6	0.7	1.9	0.7	0.1	0.8	-1.4	0.6
Vertical activity count, locomotor time 2	0.1	0.1	0.4	0.3	0.6	-0.1	-0.4	-0.3
Light reinforcement 1	0.5	1.0	1.9	-0.2	1.4	1.2	0.2	1.2
Light reinforcement 2	0.7	1.0	2.1	-0.5	1.5	1.1	0.6	1.1
Bone: marrow area	1.4	3.0	7.7	2.8	-1.4	-1.6	-1.4	-0.9
Bone: maximum diameter	5.7	10.5	29.0	5.4	-2.7	-2.7	-2.7	-1.4
Bone: maximum force	2.1	3.7	9.2	3.0	-1.7	-2.2	-0.6	-1.1
Bone: maximum moment	2.4	4.1	9.6	3.1	-2.0	-2.2	-0.8	-1.2
Mean time between licks in bursts	0.4	0.5	1.1	0.9	-0.4	0.5	-1.0	0.7
Mean num. licks in bursts	1.8	2.1	3.7	-1.9	-0.1	-1.2	1.5	-1.7
Cd content in liver	1.2	1.3	3.1	-0.1	0.9	1.8	-0.1	1.7
Co content in liver	1.7	2.0	7.4	-2.7	0.1	-0.3	1.2	-0.8
Cu content in liver	0.5	0.6	1.0	-0.7	-1.0	-0.5	0.6	-0.8
Fe content in liver	0.2	0.2	0.5	-0.7	0.1	0.5	-0.3	-0.4
K content in liver	0.7	0.7	2.2	-1.5	0.7	0.9	-0.2	0.2
Mg content in liver	0.6	0.6	1.4	0.2	0.1	1.0	-1.2	0.6
Mn content in liver	0.4	0.4	0.7	-0.8	0.8	0.4	0.7	0.1
Na content in liver	1.2	1.3	2.6	0.6	1.1	1.3	-0.7	1.6
Rb content in liver	1.8	2.2	4.8	-0.7	1.4	2.2	-1.1	1.6
Se content in liver	0.7	0.8	2.2	0.2	1.5	0.8	0.1	1.1
Sr content in liver	1.0	0.9	2.1	-1.0	1.0	0.5	1.4	0.6
Zn content in liver	2.2	2.5	5.5	-2.3	1.8	0.6	1.8	0.2
Bone: minimum diameter	3.2	6.0	14.3	3.8	-2.6	-2.0	-1.9	-1.2
Time in familiar zone, hab. session 1	1.3	1.3	3.2	-0.9	1.8	-0.2	1.4	-0.4
Time in novel zone, hab. session 1	2.4	2.3	5.0	2.2	-1.8	0.0	-1.8	0.5
Total zone transitions, hab. session 1	0.8	1.1	2.6	0.7	-0.6	-1.6	-0.1	-1.4
Total locomotion distance, hab. session 1	0.1	0.2	0.6	0.8	-0.1	-0.2	-0.6	0.1
Locomotion velocity, hab. session 1	0.1	0.1	0.3	0.4	0.2	-0.0	-0.5	0.1
Time in familiar zone, hab. session 2	2.4	2.5	5.7	2.3	-1.2	0.0	-2.4	-0.0
Time in novel zone, hab. session 2	1.6	1.6	3.9	-1.7	0.8	-0.5	2.0	-0.4
Total zone transitions, hab. session 2	1.2	1.5	2.6	0.6	-1.5	-1.5	-0.3	-1.6
Total locomotion distance, hab. session 2	0.7	0.9	1.6	0.3	-1.3	-1.1	-0.5	-1.2
Locomotion velocity, hab. session 2	0.4	0.6	1.0	0.2	-1.0	-1.0	-0.2	-1.0
Novel to familiar place preference ratio	0.3	0.3	0.4	0.4	-0.6	0.5	-0.7	0.6
Novelty place preference	0.4	0.4	0.6	0.7	-0.7	0.4	-0.8	0.5
Time in novel zone, NPP test	0.9	1.0	1.7	1.1	-1.2	0.4	-1.3	0.5
Total zone transitions, NPP test	1.1	1.5	2.7	1.1	-1.7	-1.2	-1.0	-1.2
Total locomotion distance, NPP test	0.8	1.0	1.9	0.8	-1.4	-0.8	-1.1	-0.9
Locomotion velocity, NPP test	0.3	0.5	0.9	0.2	-0.8	-0.9	-0.3	-0.9
Intraocular pressure	3.2	4.4	7.6	2.8	-2.7	-0.4	-2.6	-0.6
Delta distance traveled before/after self-admin	1.1	1.1	2.0	1.4	-1.3	-1.0	-0.3	-1.0
Delta ambulatory time before/after self-admin	1.3	1.4	3.5	1.9	-1.4	-0.4	-1.1	-0.3
Parametrial fat weight	5.0	9.7	20.2	3.5	-4.5	-2.0	-3.1	-1.7
Pavlov. Cond. lever latency	0.3	0.4	0.9	0.8	0.2	0.4	-0.9	-0.3
Pavlov. Cond. magazine entry latency	0.3	0.4	0.9	-0.5	-1.0	-0.7	-0.3	-0.6
Pavlov. Cond. change in total contacts	0.4	0.4	0.6	-0.8	0.1	-0.7	0.7	-0.5
Pavlov. Cond. index score	0.5	0.6	0.9	-1.0	-0.9	-0.9	0.3	-0.7
Pavlov. Cond. latency score	0.4	0.5	0.9	-0.9	-0.7	-0.8	0.4	-0.6
Pavlov. Cond. lever contacts	0.1	0.1	0.3	-0.6	-0.0	-0.0	0.3	0.5
Pavlov. Cond. magazine entry number	1.1	1.4	2.3	0.8	1.5	1.4	-0.1	1.4
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.5	0.7	-0.5	-0.0	-0.2	-0.4
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.7	-0.9	-0.8	-0.7	0.1	-0.5
Pavlov. Cond. response bias	0.5	0.7	1.2	-0.9	-1.1	-0.9	0.4	-0.5
Pavlov. Cond. lever latency	3.1	4.1	7.8	-2.6	1.0	-1.3	2.8	-1.9
Pavlov. Cond. magazine entry latency	0.9	1.1	2.5	0.9	-1.3	-0.4	-1.6	-0.3
Pavlov. Cond. change in total contacts	2.7	3.7	7.6	2.4	-1.8	0.8	-2.8	1.1
Pavlov. Cond. index score	2.3	3.0	6.2	2.4	-1.6	0.2	-2.5	0.7
Pavlov. Cond. latency score	2.3	2.8	6.0	2.2	-1.6	0.2	-2.5	0.7
Pavlov. Cond. lever contacts	1.7	2.3	4.3	2.1	-1.4	0.5	-2.0	1.0
Pavlov. Cond. magazine entry number	1.0	1.2	2.6	-1.1	1.4	0.3	1.6	0.2
Pavlov. Cond. intertrial magazine entries	0.4	0.5	2.6	1.6	0.1	-0.3	0.1	0.2
Pavlov. Cond. lever-magazine prob. diff.	2.1	2.6	5.6	2.4	-1.4	0.1	-2.3	0.7
Pavlov. Cond. response bias	1.9	2.6	5.1	2.3	-1.5	0.2	-2.2	0.8
Time in closed arm before self-admin	0.4	0.4	1.0	-0.4	0.4	-1.0	0.7	-0.6
Time in closed arm after self-admin	0.3	0.3	0.6	-0.8	0.8	-0.1	0.3	-0.2
Time in open arm before self-admin	0.9	0.9	1.5	-1.2	1.0	1.2	-0.0	0.9
Time in open arm after self-admin	1.4	1.5	2.7	0.5	0.0	1.7	-1.4	1.6
Bone: periosteal estimation	4.5	9.3	22.4	4.7	-2.8	-3.0	-2.1	-1.8
Bone: periosteal perimeter	7.2	12.0	30.3	5.5	-3.2	-3.3	-2.1	-2.0
Bone: post-yield work	1.0	1.4	3.9	2.0	-0.7	0.3	-1.1	1.1
Progressive ratio test 1 active lever presses	0.5	0.5	1.4	1.2	-0.7	-0.1	-0.8	0.1
Progressive ratio test 1 breakpoint	0.5	0.5	0.9	1.0	-0.3	0.4	-0.9	0.6
Progressive ratio test 1 inactive lever presses	0.3	0.3	0.7	0.9	-0.6	-0.1	-0.5	0.6
Progressive ratio test 2 active lever presses	1.2	1.3	3.3	1.8	-1.5	-0.6	-0.8	-0.1
Progressive ratio test 2 breakpoint	1.2	1.4	3.5	1.9	-1.5	-0.4	-1.0	0.0
Progressive ratio test 2 inactive lever presses	1.1	1.3	3.4	1.8	-1.4	-0.3	-0.8	0.5
Incentive Sensitization - Responses	0.9	1.0	2.4	1.5	-1.4	-0.6	-0.5	0.1
Incentive Sensitization - Breakpoint	1.0	1.0	2.6	1.6	-1.4	-0.5	-0.6	0.2
Sum of active levers in priming session hrs 5-6	1.0	1.0	2.0	-0.7	1.1	1.4	0.1	1.1
Progressive ratio	0.8	0.9	1.5	-0.0	1.1	1.2	-0.7	1.2
Food seeking constrained by brief footshock	1.4	1.7	2.4	1.0	0.6	1.5	-1.5	1.6
Seeking ratio, punishment vs. effort	0.1	0.1	0.3	0.6	-0.5	-0.3	0.0	-0.2
Retroperitoneal fat weight	7.6	24.9	43.2	4.8	-6.6	-5.5	-2.2	-4.8
Reaction time number correct	0.8	1.2	2.5	1.4	-1.6	-0.5	-0.9	-0.4
Reaction time mean minus median	0.2	0.3	0.9	1.0	0.1	-0.2	-0.6	-0.1
Reaction time mean minus median AUC	0.3	0.4	0.9	0.5	-0.2	-1.0	0.2	-0.8
Reaction time num false alarms	0.1	0.1	0.4	0.2	-0.3	0.2	-0.6	0.3
Reaction time num false alarms AUC	0.0	0.0	0.1	-0.2	-0.3	-0.1	-0.3	0.0
Reaction time trials correct on left	0.8	1.2	2.5	1.4	-1.6	-0.5	-0.9	-0.4
Reaction time trials on left	0.9	1.2	2.4	1.5	-1.6	-0.6	-1.0	-0.5
Reaction time mean	0.2	0.3	0.8	-0.3	0.9	-0.4	0.7	-0.4
Reaction time mean AUC	0.2	0.3	0.9	-0.5	0.9	0.0	0.6	-0.0
Median of all reaction times	0.6	0.8	1.5	-0.8	1.1	-0.6	1.2	-0.6
Reaction time omissions	0.4	0.5	2.1	1.5	-0.2	-0.4	-0.5	-0.1
Reaction time false alarm rate	0.2	0.2	0.3	-0.6	0.5	0.4	-0.1	0.5
Reaction time premature initiation rate	1.3	1.7	3.5	-1.6	0.1	-1.2	1.1	-1.9
Reaction time premature initiations	1.3	1.9	5.1	-0.7	-0.9	-1.6	0.6	-2.3
Std. dev. reaction times	0.5	0.7	1.1	1.1	-0.9	-0.9	-0.5	-0.7
Reaction time trials completed	0.9	1.2	2.4	1.5	-1.6	-0.6	-1.0	-0.5
Reaction time trials AUC	0.9	1.2	2.3	1.5	-1.5	-0.5	-1.0	-0.5
Run reversals in cocaine runway, females	0.6	0.6	1.7	-0.3	-0.2	-1.0	0.5	-1.3
Run reversals in cocaine runway, males	1.0	1.0	1.9	-0.0	1.3	1.1	0.0	1.4
Latency to leave start box in cocaine runway	0.4	0.4	0.6	-0.8	0.8	0.5	0.6	0.4
Latency to leave start box in cocaine runway, F	0.8	0.9	2.4	-1.5	0.9	0.1	1.1	-0.1
Latency to leave start box in cocaine runway, M	0.2	0.2	0.5	0.7	-0.2	0.3	-0.7	0.3
Std. dev. time between licks in bursts	1.6	2.0	3.1	1.8	-0.5	1.1	-1.7	1.5
Total sessions with >9 infusions	1.8	1.9	2.8	1.2	-1.7	-1.7	-0.3	-1.6
Short access day 1 total inactive lever presses	0.8	0.9	2.9	0.8	-1.7	-0.7	-0.4	-0.4
Short access day 10 total inactive lever presses	0.5	0.5	2.2	0.4	-1.5	-0.5	-0.2	-0.2
Short access day 1 total infusions	0.2	0.2	0.4	0.6	-0.2	-0.7	0.0	-0.3
Short access day 10 total infusions	0.5	0.5	0.8	0.8	0.2	0.6	-0.9	0.8
Short access total infusions	0.5	0.6	1.5	1.2	-0.2	0.3	-1.0	0.5
Short access day 1 locomotion	0.3	0.3	0.7	0.7	-0.3	0.2	-0.9	0.2
Short access day 10 total locomotion	1.2	1.4	2.8	-0.5	-0.3	-1.7	1.2	-1.5
Short access total locomotion	0.5	0.5	1.3	-0.3	0.0	-1.0	0.6	-1.1
One hour access (0.3 mA shock)	3.1	3.6	7.7	2.8	-1.9	0.5	-2.3	1.1
Compulsive drug intake	0.7	0.7	1.1	0.7	-0.3	0.9	-0.9	1.1
One hour access (shock baseline)	0.9	1.0	2.1	1.4	-1.4	-0.6	-0.8	-0.3
Social response proportion	2.7	2.9	6.9	-0.0	-0.7	-2.6	1.3	-2.3
Social responses	2.2	2.8	5.1	1.7	-2.3	-1.5	-1.6	-1.0
Social time	0.9	1.2	2.1	-0.2	-1.4	-1.5	0.3	-1.4
Soleus weight	2.8	8.3	17.4	-0.2	-3.2	-3.7	0.2	-4.2
Bone: stiffness	1.3	2.0	6.8	2.6	-0.6	-1.7	0.0	-0.3
Tibialis anterior weight	0.1	0.5	1.2	-0.2	-0.1	1.1	-1.0	0.5
Time to tail flick, vehicle, before self-admin	0.8	0.8	1.7	1.1	-1.3	-0.6	-0.8	-0.6
Time to tail flick, vehicle, after self-admin	0.4	0.4	0.8	-0.5	-0.0	-0.7	0.9	-0.6
Time to tail flick, test, before self-admin	1.9	1.9	3.5	-1.2	0.3	-1.7	1.2	-1.9
Time to tail flick, test, after self-admin	1.0	1.1	1.6	1.3	-1.3	-0.9	-0.9	-0.7
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.4	-0.5	0.7	-0.3	0.6	0.1
Delta time to tail flick, test, before/after SA	1.2	1.1	2.4	1.5	-1.3	-0.0	-1.2	0.2
Tibia length	1.3	3.7	9.2	1.7	-1.0	-3.0	0.5	-2.3
Ambulatory time before self-admin	2.4	2.5	3.9	-1.4	-0.7	-1.7	2.0	-1.8
Ambulatory time after self-admin	2.5	2.8	4.6	-0.9	-1.0	-2.1	1.8	-2.1
Bone: tissue strength	0.2	0.2	0.5	0.2	0.4	0.7	-0.3	0.7
Total heroin consumption	1.3	1.5	2.7	1.6	-1.7	0.3	-1.5	0.0
Bone: trabecular number	0.8	1.3	2.3	1.5	-1.3	0.2	-1.4	0.4
Bone: trabecular spacing	0.1	0.1	0.2	-0.4	0.1	0.5	-0.0	0.5
Bone: trabecular thickness	3.6	4.3	8.6	2.9	-2.2	-1.3	-2.2	-1.1
Bone: trabecular tissue density	0.5	0.7	1.4	1.0	-0.3	-1.2	0.9	-0.4
Water consumed over 24 hours	0.8	1.0	2.2	0.2	0.3	-1.5	0.9	-1.4
Number of responses in last shaping day	0.1	0.1	0.3	-0.5	-0.3	-0.2	0.0	-0.5