Hub : Genes

Trim54

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	mRNA stability	Trim54	0.08	0.09	2.6e-03	0.05	0.04	0.02	0.04	1.2e-03	3.4e-03	4.0e-02	3.0e-03
2	Brain	gene expression	Trim54	0.12	0.1	3.7e-09	0.07	0.09	0.07	0.07	5.0e-07	1.5e-08	1.7e-07	2.2e-07
3	PL	gene expression	Trim54	0.06	0.07	5.4e-05	0.04	0.04	0.04	0.04	4.6e-05	1.1e-05	1.3e-05	2.0e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	4.5	8.3	9.7	3.1	-2.8	-2.7
Area under the delay curve	0.1	0.2	0.3	0.6	-0.1	-0.5
BMI with tail	0.3	1.1	1.2	-1.1	1.1	1.0
BMI without tail	0.4	2.2	2.3	-1.5	1.4	1.5
Body weight	2.4	10.5	11.5	-3.4	3.3	3.1
Weight adjusted by age	0.0	0.1	0.1	0.3	-0.4	-0.3
Bone surface	2.4	4.7	6.1	2.5	-2.1	-1.9
Bone volume	2.4	4.7	6.0	2.4	-2.1	-1.9
Breakpoint value in progressive ratio session	0.6	1.0	1.4	0.9	-0.9	-1.2
Number of licking bursts	0.0	0.0	0.1	0.3	-0.0	-0.1
Context. condit. distance diff. score	0.0	0.0	0.0	-0.0	-0.0	-0.0
Locomotion velocity, session 1	0.0	0.0	0.1	0.1	0.1	0.3
Locomotion distance, session 1	1.7	2.2	3.0	1.7	-1.4	-1.3
Locomotion velocity, session 2	0.2	0.3	0.3	-0.5	0.6	0.5
Locomotion distance, session 2	0.0	0.0	0.0	0.2	-0.0	0.1
Locomotion velocity, session 3	0.8	0.9	1.0	0.9	-1.0	-1.0
Locomotion distance, session 3	0.8	0.9	1.0	1.0	-0.9	-0.9
Stereotopy head waving bouts, day 3	2.1	2.5	2.6	1.5	-1.6	-1.6
Stereotopy head waving duration, day 3	0.2	0.2	0.3	0.3	-0.5	-0.5
Locomotion velocity, session 7	1.2	1.4	1.7	1.3	-1.2	-1.0
Locomotion distance, session 7	0.1	0.1	0.1	0.4	-0.2	-0.0
Stereotopy head waving bouts, day 7	0.0	0.0	0.0	0.1	-0.1	-0.1
Stereotopy head waving duration, day 7	0.3	0.4	0.5	0.5	-0.6	-0.7
Locomotion velocity, session 8	0.2	0.3	0.4	0.5	-0.6	-0.4
Locomotion distance, session 8	0.3	0.4	0.5	0.7	-0.7	-0.5
Degree of sensitization distance	0.8	0.9	1.0	-0.9	0.9	1.0
Degree of sensitization stereotypy	0.2	0.2	0.2	-0.5	0.5	0.4
Conditioned locomotion	3.1	3.6	3.7	1.9	-1.9	-1.9
Cocaine response after cond. corrected	0.5	0.7	0.8	0.9	-0.7	-0.8
Cocaine response after cond. not corrected	1.3	1.9	2.3	1.5	-1.2	-1.3
Cocaine response before conditioning	1.6	2.0	2.2	1.5	-1.4	-1.3
Saline control response	0.6	0.9	1.0	1.0	-1.0	-0.9
Bone: connectivity density	4.5	7.3	8.3	2.9	-2.6	-2.6
Bone: cortical apparent density	0.4	0.6	0.9	0.9	-0.7	-0.8
Bone: cortical area	0.5	0.8	1.1	1.0	-0.9	-0.8
Bone: cortical porosity	1.2	1.3	1.5	1.1	-1.2	-1.1
Bone: cortical porosity	1.3	1.4	1.6	1.2	-1.3	-1.2
Bone: cortical thickness	0.0	0.0	0.0	0.1	0.1	0.2
Bone: cortical thickness	1.3	1.6	1.8	1.3	-1.3	-1.2
Bone: cortical tissue density	0.3	0.4	0.6	0.8	-0.6	-0.6
Condit. Reinf. active minus inactive responses	0.7	0.7	0.9	-0.8	1.0	0.8
Condit. Reinf. active-inactive response ratio	0.8	0.8	1.0	-0.9	1.0	0.8
Condit. Reinf. active responses	0.1	0.2	0.2	0.5	-0.3	-0.4
Condit. Reinf. inactive responses	1.6	2.0	2.4	1.6	-1.4	-1.3
Incentive salience index mean	0.0	0.0	0.0	0.2	0.0	-0.1
Condit. Reinf. lever presses	0.6	0.9	1.2	1.1	-0.9	-0.9
Condit. Reinf. active minus inactive responses	3.1	4.8	5.4	2.0	-2.2	-2.3
Condit. Reinf. active-inactive response ratio	0.7	1.1	1.3	0.9	-1.1	-1.1
Condit. Reinf. active responses	3.2	4.5	5.0	2.1	-2.1	-2.2
Condit. Reinf. inactive responses	1.4	2.1	2.3	1.5	-1.4	-1.5
Condit. Reinf. lever presses	1.9	2.7	3.0	1.6	-1.6	-1.7
Condit. Reinf. lever reinforcers received	2.9	4.1	4.5	2.0	-2.0	-2.1
Conditioned reinforcement - actives	0.4	1.6	2.3	0.8	-1.5	-1.4
Conditioned reinforcement - inactives	1.7	4.7	5.9	2.4	-2.1	-1.9
Conditioned locomotion	0.1	0.1	0.3	0.0	-0.6	-0.3
Patch foraging indifference point 0 sec	0.2	0.7	0.7	-0.8	0.8	0.8
Patch foraging indifference point AUC	0.7	1.7	1.9	1.4	-1.4	-1.1
Delay disc. indifference point, 0s delay	2.8	3.1	3.9	-1.6	2.0	1.7
Delay disc. indifference point, 16s delay	0.1	0.2	0.2	0.4	-0.1	-0.5
Delay disc. indifference point, 2s delay	0.1	0.2	0.2	-0.3	0.4	0.4
Delay disc. indifference point, 24s delay	0.8	1.2	1.9	1.1	-0.8	-1.4
Delay disc. indifference point, 4s delay	0.0	0.0	0.1	0.3	-0.0	-0.1
Delay disc. indifference point, 8s delay	0.0	0.1	0.2	0.3	-0.0	-0.4
Indifference point function ln k	0.0	0.0	0.0	0.1	-0.2	-0.1
Indifference point function log k	0.0	0.0	0.0	0.1	-0.2	-0.1
Patch foraging total patch changes 0 sec	0.2	0.6	0.6	-0.7	0.8	0.8
Patch foraging total patch changes 12 sec	1.0	1.3	1.4	-1.1	1.2	1.2
Patch foraging total patch changes 18 sec	0.0	0.1	0.2	-0.3	0.3	0.4
Patch foraging total patch changes 24 sec	0.4	1.4	1.6	-1.2	1.0	1.3
Patch foraging total patch changes 6 sec	0.1	0.1	0.2	-0.3	0.4	0.4
Patch foraging time to switch 0 sec	0.0	0.0	0.1	-0.2	0.2	-0.0
Patch foraging water rate 0 sec	0.0	0.0	0.0	0.1	-0.2	-0.0
Patch foraging water rate 12 sec	0.5	2.1	2.4	-1.5	1.4	1.4
Patch foraging water rate 18 sec	0.3	0.7	0.7	-0.8	0.8	0.8
Patch foraging water rate 24 sec	2.3	3.2	4.2	-2.0	1.8	1.5
Patch foraging water rate 6 sec	1.1	1.7	1.7	-1.3	1.3	1.3
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.1	-0.0	0.0	0.4
Distance traveled before self-admin	0.0	0.0	0.0	-0.2	0.1	0.2
Distance traveled after self-admin	1.6	2.7	3.0	-1.7	1.6	1.6
Extensor digitorum longus weight	4.5	17.9	18.1	4.2	-4.2	-4.3
Bone: elastic displacement	0.6	0.7	0.9	0.7	-0.8	-1.0
Bone: elastic work	0.9	1.1	1.3	1.0	-1.0	-1.2
Bone: endosteal estimation	0.6	1.4	1.4	1.2	-1.2	-1.1
Bone: endosteal perimeter	0.2	0.5	0.5	0.7	-0.7	-0.7
Epididymis fat weight	11.8	59.4	65.1	-8.1	7.7	7.4
Delta time in closed arm before/after self-admin	0.0	0.0	0.0	0.0	-0.1	-0.1
Delta time in open arm before/after self-admin	0.1	0.1	0.2	0.3	-0.4	-0.4
Diff in mean of infusions in LGA sessions	0.0	0.0	0.0	0.2	-0.1	-0.1
Delay discount exponential model param	0.4	0.5	0.7	-0.8	0.5	0.8
Extinction: sum of active levers before priming	0.2	0.3	0.5	0.4	-0.5	-0.7
Active lever presses in extinction session 6	0.5	0.5	0.7	0.5	-0.8	-0.8
Bone: final force	0.1	0.1	0.1	0.4	-0.4	-0.3
Bone: final moment	0.1	0.2	0.2	0.5	-0.4	-0.3
Food consumed during 24 hour testing period	0.1	0.2	0.3	0.5	-0.5	-0.4
Glucose	0.2	0.4	0.5	-0.6	0.6	0.7
Heart weight	2.9	4.6	5.5	-1.9	2.1	2.3
Delay discount hyperbolic model param	0.2	0.3	0.5	-0.7	0.3	0.6
Intermittent access intake day 1-15 change	0.0	0.1	0.1	-0.3	-0.3	-0.1
Intermittent access intake escalation	0.0	0.1	0.3	-0.6	-0.0	0.2
Intermittent access intake escalation 2	0.0	0.0	0.1	-0.1	-0.1	0.3
Intermitt. access day 1 inactive lever presses	0.1	1.8	2.2	1.5	-1.4	-1.2
Intermitt. access day 15 inactive lever presses	1.5	8.1	9.9	3.1	-3.0	-2.4
Intermitt. access escalation Index	0.2	0.5	0.7	-0.7	0.6	0.8
Intermittent access day 1 total infusions	1.8	5.4	5.7	2.4	-2.3	-2.3
Intermittent access day 15 total infusions	0.8	1.9	2.4	1.2	-1.6	-1.3
Intermittent access terminal intake (last 3 days)	1.6	2.7	3.3	1.5	-1.8	-1.6
Intermittent access total infusions	2.0	2.4	2.8	1.3	-1.7	-1.7
Intermittent access day 1 locomotion	1.3	2.3	2.5	1.5	-1.5	-1.6
Intermittent access day 15 total locomotion	0.1	0.3	0.4	0.5	-0.6	-0.5
Intermittent access total locomotion	0.3	0.3	0.4	0.4	-0.6	-0.6
Intermittent access standard deviation	0.3	1.7	1.8	1.3	-1.3	-1.2
Left kidney weight	0.0	0.0	0.1	-0.2	0.2	0.1
Right kidney weight	0.3	2.0	2.5	-1.4	1.6	1.3
Cocaine induced anxiety	0.1	0.3	0.3	0.6	-0.6	-0.4
Post-drug Anxiety	1.2	1.4	1.5	-1.1	1.2	1.2
Baseline Anxiety	2.3	3.9	4.2	-2.0	2.0	1.9
Tail length	0.3	1.8	2.0	-1.4	1.3	1.4
Length with tail	2.0	8.7	9.8	-3.1	2.9	2.8
Length without tail	0.4	2.2	2.6	-1.6	1.5	1.4
Times rat made contact with spout	1.9	2.2	2.3	1.5	-1.4	-1.5
Lifetime Intake	2.2	2.7	3.1	1.4	-1.8	-1.7
Liver weight, left	3.8	6.5	6.6	-2.5	2.6	2.5
Liver weight, right	10.1	17.6	18.1	-4.3	4.2	4.2
Locomotor activity	0.2	0.3	0.6	-0.5	0.8	0.5
Locomotor testing distance	0.1	0.2	0.4	0.4	-0.3	-0.6
Locomotor testing rearing	0.3	1.0	1.5	0.7	-1.0	-1.2
Locomotion in novel chamber	0.4	0.5	1.3	-1.1	0.4	0.4
Locomotion in novel chamber post-restriction	1.6	4.8	5.3	-2.3	2.3	2.0
Fecal boli incidents, locomotor time 1	0.1	0.3	0.3	0.4	-0.6	-0.5
Change in fecal boli incidents, locomotor task	4.2	4.4	4.6	-2.1	2.1	2.0
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.2	-0.4	0.4	0.1
Bouts of movement, locomotor time 1	1.4	1.9	2.0	1.3	-1.4	-1.4
Total resting periods, locomotor time 1	1.9	2.2	2.4	1.5	-1.5	-1.5
Rest time, locomotor task time 1	0.0	0.1	0.1	-0.3	0.2	0.3
Distance moved, locomotor task time 1	0.4	1.2	1.4	-1.2	1.2	1.0
Vertical activity count, locomotor time 1	0.1	0.6	0.8	-0.9	0.8	0.6
Time >=10cm from walls, locomotor time 2	0.1	0.2	0.3	0.4	-0.5	-0.4
Bouts of movement, locomotor time 2	0.0	0.1	0.2	-0.4	0.2	0.3
Total resting periods, locomotor time 2	0.0	0.0	0.0	-0.0	-0.1	0.0
Rest time, locomotor task time 2	1.1	1.8	2.3	1.5	-1.2	-1.2
Distance moved, locomotor task time 2	1.0	1.3	1.6	-1.3	1.1	1.1
Vertical activity count, locomotor time 2	0.3	0.8	1.2	-1.1	0.7	0.8
Light reinforcement 1	1.6	7.3	8.8	3.0	-2.7	-2.5
Light reinforcement 2	2.2	4.9	6.3	2.5	-2.2	-1.9
Bone: marrow area	0.5	1.3	1.4	1.2	-1.2	-1.1
Bone: maximum diameter	1.0	2.0	2.2	1.5	-1.4	-1.3
Bone: maximum force	0.1	0.2	0.3	0.5	-0.5	-0.4
Bone: maximum moment	0.2	0.3	0.4	0.6	-0.6	-0.5
Mean time between licks in bursts	0.6	3.8	3.9	-1.9	2.0	1.9
Mean num. licks in bursts	0.1	0.2	0.2	0.4	-0.5	-0.5
Cd content in liver	0.0	0.0	0.0	0.0	-0.0	-0.0
Co content in liver	5.9	6.9	7.2	2.7	-2.6	-2.6
Cu content in liver	0.1	0.1	0.1	0.3	-0.3	-0.3
Fe content in liver	0.9	1.1	1.3	1.0	-1.1	-1.1
K content in liver	0.4	0.4	0.6	0.8	-0.6	-0.4
Mg content in liver	0.4	0.4	0.7	0.8	-0.6	-0.5
Mn content in liver	0.1	0.1	0.1	0.3	-0.2	-0.2
Na content in liver	0.5	0.6	0.6	0.8	-0.8	-0.7
Rb content in liver	0.0	0.0	0.0	0.1	-0.0	-0.1
Se content in liver	0.1	0.1	0.1	-0.4	0.3	0.3
Sr content in liver	0.2	0.1	0.2	-0.4	0.4	0.4
Zn content in liver	0.8	1.0	1.1	-1.0	1.0	1.0
Bone: minimum diameter	0.0	0.1	0.1	-0.1	0.2	0.3
Time in familiar zone, hab. session 1	0.6	0.7	0.8	-0.8	0.8	0.9
Time in novel zone, hab. session 1	0.5	0.5	0.8	-0.9	0.7	0.6
Total zone transitions, hab. session 1	0.1	0.2	0.2	0.5	-0.4	-0.3
Total locomotion distance, hab. session 1	0.2	0.3	0.4	0.6	-0.5	-0.4
Locomotion velocity, hab. session 1	1.0	1.5	1.9	1.4	-1.2	-1.1
Time in familiar zone, hab. session 2	0.0	0.0	0.0	0.0	-0.1	-0.0
Time in novel zone, hab. session 2	0.5	0.5	0.6	-0.8	0.8	0.6
Total zone transitions, hab. session 2	0.1	0.1	0.2	0.4	-0.2	-0.3
Total locomotion distance, hab. session 2	0.2	0.2	0.4	0.6	-0.4	-0.3
Locomotion velocity, hab. session 2	0.4	0.5	0.7	0.9	-0.6	-0.6
Novel to familiar place preference ratio	0.8	1.1	1.2	-1.0	1.1	1.0
Novelty place preference	1.4	1.7	1.9	-1.3	1.4	1.3
Time in novel zone, NPP test	1.6	2.0	2.1	-1.4	1.5	1.3
Total zone transitions, NPP test	1.5	2.2	2.5	1.6	-1.4	-1.4
Total locomotion distance, NPP test	2.0	2.8	3.1	1.8	-1.6	-1.6
Locomotion velocity, NPP test	3.3	4.6	5.2	2.3	-2.1	-2.1
Intraocular pressure	5.2	8.4	9.3	-2.9	3.0	2.7
Delta distance traveled before/after self-admin	1.7	1.9	2.1	-1.4	1.3	1.4
Delta ambulatory time before/after self-admin	0.1	0.2	0.3	-0.5	0.4	0.5
Parametrial fat weight	11.9	28.0	30.3	-5.1	5.3	5.5
Pavlov. Cond. lever latency	1.8	2.3	2.9	-1.7	1.5	1.4
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	0.4	-0.3	-0.2
Pavlov. Cond. change in total contacts	0.0	0.1	0.1	0.3	-0.2	-0.1
Pavlov. Cond. index score	0.8	1.0	1.4	1.2	-0.9	-0.8
Pavlov. Cond. latency score	0.8	1.0	1.4	1.2	-0.9	-0.8
Pavlov. Cond. lever contacts	1.2	1.5	1.9	1.4	-1.1	-1.1
Pavlov. Cond. magazine entry number	0.5	0.6	0.9	-1.0	0.7	0.6
Pavlov. Cond. intertrial magazine entries	1.2	1.5	1.7	1.2	-1.2	-1.3
Pavlov. Cond. lever-magazine prob. diff.	1.4	1.8	2.3	1.5	-1.3	-1.2
Pavlov. Cond. response bias	1.4	1.8	2.3	1.5	-1.3	-1.2
Pavlov. Cond. lever latency	1.4	2.0	2.1	-1.4	1.4	1.4
Pavlov. Cond. magazine entry latency	0.2	0.3	0.4	0.6	-0.6	-0.4
Pavlov. Cond. change in total contacts	0.4	1.0	1.1	1.0	-1.0	-1.1
Pavlov. Cond. index score	1.0	1.5	1.6	1.2	-1.3	-1.2
Pavlov. Cond. latency score	1.0	1.5	1.7	1.2	-1.3	-1.2
Pavlov. Cond. lever contacts	0.9	1.4	1.5	1.1	-1.2	-1.2
Pavlov. Cond. magazine entry number	0.1	0.2	0.2	-0.4	0.5	0.4
Pavlov. Cond. intertrial magazine entries	2.5	5.5	5.9	-2.4	2.4	2.2
Pavlov. Cond. lever-magazine prob. diff.	0.6	1.0	1.1	1.0	-1.0	-1.0
Pavlov. Cond. response bias	1.6	2.2	2.3	1.4	-1.5	-1.5
Time in closed arm before self-admin	0.5	0.9	1.0	-0.9	1.0	1.0
Time in closed arm after self-admin	1.2	1.4	1.7	-1.3	1.2	1.1
Time in open arm before self-admin	0.1	0.1	0.1	0.3	-0.2	-0.3
Time in open arm after self-admin	1.5	1.6	1.8	1.3	-1.3	-1.2
Bone: periosteal estimation	0.9	2.1	2.4	1.5	-1.4	-1.3
Bone: periosteal perimeter	0.4	0.7	0.8	0.9	-0.8	-0.8
Bone: post-yield work	0.7	1.3	1.5	1.0	-1.2	-1.2
Progressive ratio test 1 active lever presses	1.0	1.8	1.8	1.3	-1.3	-1.3
Progressive ratio test 1 breakpoint	1.0	1.8	1.8	1.3	-1.3	-1.4
Progressive ratio test 1 inactive lever presses	1.5	4.0	4.8	1.9	-2.2	-1.9
Progressive ratio test 2 active lever presses	0.1	0.2	0.3	0.2	-0.6	-0.5
Progressive ratio test 2 breakpoint	0.1	0.1	0.2	0.1	-0.5	-0.4
Progressive ratio test 2 inactive lever presses	0.6	1.8	2.5	1.2	-1.6	-1.2
Incentive Sensitization - Responses	0.0	0.1	0.1	-0.0	-0.4	-0.2
Incentive Sensitization - Breakpoint	0.0	0.0	0.1	-0.1	-0.3	-0.1
Sum of active levers in priming session hrs 5-6	0.7	0.7	1.3	1.1	-0.6	-0.7
Progressive ratio	0.0	0.0	0.1	-0.2	0.1	0.2
Food seeking constrained by brief footshock	3.5	4.4	4.9	2.0	-2.2	-2.1
Seeking ratio, punishment vs. effort	0.3	0.6	0.8	0.9	-0.7	-0.8
Retroperitoneal fat weight	21.7	96.9	98.1	-9.9	9.9	9.8
Reaction time number correct	0.3	0.9	1.2	1.1	-0.9	-0.9
Reaction time mean minus median	0.0	0.0	0.0	-0.0	-0.0	0.0
Reaction time mean minus median AUC	0.0	0.1	0.1	-0.2	0.3	0.3
Reaction time num false alarms	0.0	0.0	0.1	0.3	0.1	-0.0
Reaction time num false alarms AUC	0.0	0.0	0.1	0.3	0.1	-0.1
Reaction time trials correct on left	0.3	0.9	1.2	1.1	-0.9	-0.9
Reaction time trials on left	0.3	1.0	1.3	1.1	-0.9	-0.9
Reaction time mean	0.8	1.7	1.9	-1.2	1.3	1.4
Reaction time mean AUC	0.6	1.4	1.6	-1.0	1.2	1.2
Median of all reaction times	1.2	1.9	2.2	-1.2	1.4	1.5
Reaction time omissions	0.1	0.1	0.2	0.4	-0.3	-0.2
Reaction time false alarm rate	0.1	0.2	0.3	-0.2	0.5	0.4
Reaction time premature initiation rate	0.1	0.2	0.2	-0.4	0.5	0.4
Reaction time premature initiations	0.0	0.0	0.1	0.2	-0.1	-0.1
Std. dev. reaction times	0.1	0.4	0.5	-0.5	0.7	0.7
Reaction time trials completed	0.3	1.0	1.3	1.1	-0.9	-0.9
Reaction time trials AUC	0.4	1.2	1.5	1.2	-1.1	-1.0
Run reversals in cocaine runway, females	0.0	0.0	0.1	-0.2	0.2	0.1
Run reversals in cocaine runway, males	0.1	0.1	0.2	-0.1	-0.1	-0.4
Latency to leave start box in cocaine runway	0.4	0.6	0.7	0.7	-0.8	-0.7
Latency to leave start box in cocaine runway, F	0.2	0.3	0.4	0.6	-0.5	-0.5
Latency to leave start box in cocaine runway, M	0.0	0.0	0.1	-0.1	-0.3	-0.1
Std. dev. time between licks in bursts	0.1	0.1	0.2	-0.1	0.3	0.4
Total sessions with >9 infusions	0.6	0.7	1.0	0.5	-1.0	-0.9
Short access day 1 total inactive lever presses	5.0	10.0	11.9	3.5	-3.2	-2.8
Short access day 10 total inactive lever presses	0.7	4.6	5.5	2.3	-2.1	-2.0
Short access day 1 total infusions	2.2	4.4	5.4	1.9	-2.3	-2.1
Short access day 10 total infusions	1.6	2.6	2.7	1.6	-1.6	-1.6
Short access total infusions	0.9	1.2	1.6	0.9	-1.3	-1.1
Short access day 1 locomotion	1.8	3.0	3.7	1.5	-1.9	-1.8
Short access day 10 total locomotion	0.6	2.3	2.8	1.7	-1.5	-1.4
Short access total locomotion	0.1	0.2	0.2	0.3	-0.5	-0.4
One hour access (0.3 mA shock)	1.0	1.1	1.5	0.9	-1.2	-1.0
Compulsive drug intake	0.6	0.9	1.2	-0.8	1.1	0.9
One hour access (shock baseline)	0.8	2.1	2.7	1.2	-1.6	-1.5
Social response proportion	0.3	0.4	0.4	-0.6	0.6	0.6
Social responses	0.1	0.1	0.2	-0.1	0.3	0.4
Social time	0.3	0.5	0.8	-0.6	0.5	0.9
Soleus weight	4.7	13.9	14.6	3.8	-3.6	-3.7
Bone: stiffness	0.0	0.0	0.0	0.1	-0.2	-0.1
Tibialis anterior weight	3.7	12.9	13.4	3.7	-3.5	-3.6
Time to tail flick, vehicle, before self-admin	1.0	1.3	1.8	-1.3	1.0	1.0
Time to tail flick, vehicle, after self-admin	2.4	4.9	5.5	-2.4	2.2	2.1
Time to tail flick, test, before self-admin	0.1	0.1	0.1	0.3	-0.2	-0.3
Time to tail flick, test, after self-admin	0.1	0.1	0.1	0.4	-0.3	-0.3
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.1	-0.2	0.3	0.3
Delta time to tail flick, test, before/after SA	1.2	1.5	1.7	1.3	-1.3	-1.1
Tibia length	2.7	7.6	8.2	-2.7	2.7	2.9
Ambulatory time before self-admin	0.0	0.0	0.0	0.0	-0.0	0.0
Ambulatory time after self-admin	1.1	1.7	1.9	-1.4	1.2	1.3
Bone: tissue strength	0.9	1.0	1.1	-1.0	1.0	0.9
Total heroin consumption	3.1	3.7	4.1	2.0	-1.8	-1.9
Bone: trabecular number	3.3	6.1	7.4	2.7	-2.4	-2.3
Bone: trabecular spacing	2.9	4.3	4.9	-2.2	2.1	1.9
Bone: trabecular thickness	0.7	1.0	1.3	1.1	-1.0	-0.9
Bone: trabecular tissue density	0.2	0.4	0.5	0.6	-0.7	-0.6
Water consumed over 24 hours	0.3	0.6	0.8	0.9	-0.7	-0.7
Number of responses in last shaping day	0.1	0.1	0.2	-0.0	-0.5	-0.3