Hub : Genes

Gckr

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Gckr	0.04	0.04	7.7e-04	0.02	0.02	0.02	0.02	5.4e-03	2.9e-03	3.8e-03	7.7e-03
2	Adipose	gene expression	Gckr	0.14	0.13	1.0e-10	0.09	0.09	0.09	0.09	3.2e-10	5.2e-10	3.7e-10	4.1e-10
3	Liver	gene expression	Gckr	0.03	0.03	9.4e-03	0.01	0.01	0	0.01	4.1e-02	5.0e-02	1.2e-01	7.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	5.0	8.6	8.7	3.0	2.9	-2.9
Area under the delay curve	0.1	0.1	0.2	0.5	0.2	-0.2
BMI with tail	0.3	1.0	1.1	-0.9	-1.0	1.0
BMI without tail	0.5	1.6	2.0	-1.4	-1.2	1.2
Body weight	2.1	9.3	9.3	-3.1	-3.0	3.0
Weight adjusted by age	0.0	0.0	0.0	0.1	0.1	-0.1
Bone surface	2.8	5.2	5.2	2.3	2.3	-2.3
Bone volume	2.9	5.3	5.3	2.3	2.3	-2.3
Breakpoint value in progressive ratio session	0.6	0.8	1.0	1.0	0.8	-0.8
Number of licking bursts	0.0	0.0	0.1	0.3	0.2	-0.2
Context. condit. distance diff. score	0.0	0.0	0.0	0.0	0.1	-0.1
Locomotion velocity, session 1	0.0	0.0	0.0	-0.1	0.0	-0.0
Locomotion distance, session 1	2.0	2.6	2.6	1.6	1.6	-1.6
Locomotion velocity, session 2	0.2	0.3	0.3	-0.5	-0.6	0.6
Locomotion distance, session 2	0.0	0.0	0.0	0.0	0.1	-0.1
Locomotion velocity, session 3	0.6	0.7	0.8	0.8	0.9	-0.9
Locomotion distance, session 3	0.9	0.9	0.9	0.9	1.0	-1.0
Stereotopy head waving bouts, day 3	1.9	2.3	2.3	1.5	1.5	-1.5
Stereotopy head waving duration, day 3	0.1	0.1	0.2	0.3	0.4	-0.4
Locomotion velocity, session 7	1.3	1.4	1.4	1.1	1.2	-1.2
Locomotion distance, session 7	0.1	0.1	0.1	0.2	0.4	-0.4
Stereotopy head waving bouts, day 7	0.0	0.0	0.0	0.1	0.1	-0.1
Stereotopy head waving duration, day 7	0.2	0.3	0.3	0.6	0.5	-0.5
Locomotion velocity, session 8	0.2	0.3	0.3	0.4	0.6	-0.6
Locomotion distance, session 8	0.4	0.5	0.6	0.7	0.8	-0.8
Degree of sensitization distance	0.7	0.7	0.8	-0.9	-0.8	0.8
Degree of sensitization stereotypy	0.2	0.3	0.3	-0.4	-0.5	0.5
Conditioned locomotion	2.9	3.3	3.5	1.9	1.8	-1.8
Cocaine response after cond. corrected	0.7	0.9	1.0	1.0	0.9	-0.9
Cocaine response after cond. not corrected	1.7	2.0	2.3	1.5	1.4	-1.4
Cocaine response before conditioning	1.3	1.5	1.5	1.2	1.2	-1.2
Saline control response	0.6	0.8	0.9	0.9	0.9	-0.9
Bone: connectivity density	4.6	7.2	7.5	2.7	2.7	-2.7
Bone: cortical apparent density	0.5	0.7	0.8	0.9	0.8	-0.8
Bone: cortical area	0.8	1.2	1.2	1.1	1.1	-1.1
Bone: cortical porosity	1.1	1.2	1.2	1.0	1.1	-1.1
Bone: cortical porosity	1.4	1.5	1.6	1.1	1.3	-1.3
Bone: cortical thickness	0.0	0.0	0.0	0.1	0.1	-0.1
Bone: cortical thickness	1.7	2.0	2.0	1.4	1.4	-1.4
Bone: cortical tissue density	0.4	0.5	0.5	0.7	0.7	-0.7
Condit. Reinf. active minus inactive responses	0.7	0.8	0.9	-0.8	-1.0	1.0
Condit. Reinf. active-inactive response ratio	0.9	1.0	1.1	-0.8	-1.0	1.0
Condit. Reinf. active responses	0.1	0.2	0.2	0.5	0.3	-0.3
Condit. Reinf. inactive responses	1.8	2.2	2.3	1.5	1.5	-1.5
Incentive salience index mean	0.0	0.0	0.0	0.2	-0.0	0.0
Condit. Reinf. lever presses	0.7	0.9	1.1	1.0	0.9	-0.9
Condit. Reinf. active minus inactive responses	3.3	4.3	4.5	2.1	2.0	-2.0
Condit. Reinf. active-inactive response ratio	0.8	1.0	1.0	1.0	1.0	-1.0
Condit. Reinf. active responses	2.8	3.9	4.2	2.0	1.9	-1.9
Condit. Reinf. inactive responses	1.4	1.8	2.1	1.4	1.3	-1.3
Condit. Reinf. lever presses	1.9	2.6	2.8	1.7	1.6	-1.6
Condit. Reinf. lever reinforcers received	2.5	3.5	3.7	1.9	1.8	-1.8
Conditioned reinforcement - actives	0.9	1.6	1.8	1.0	1.4	-1.4
Conditioned reinforcement - inactives	2.7	3.9	4.0	2.0	2.0	-2.0
Conditioned locomotion	0.1	0.1	0.1	-0.1	0.4	-0.4
Patch foraging indifference point 0 sec	0.5	0.9	1.0	-0.8	-1.0	1.0
Patch foraging indifference point AUC	1.8	2.6	3.0	1.4	1.7	-1.7
Delay disc. indifference point, 0s delay	3.0	3.3	3.6	-1.7	-1.9	1.9
Delay disc. indifference point, 16s delay	0.1	0.1	0.2	0.5	0.2	-0.2
Delay disc. indifference point, 2s delay	0.1	0.1	0.2	-0.4	-0.4	0.4
Delay disc. indifference point, 24s delay	1.0	1.1	1.8	1.3	0.8	-0.8
Delay disc. indifference point, 4s delay	0.0	0.0	0.0	0.1	0.1	-0.1
Delay disc. indifference point, 8s delay	0.0	0.0	0.1	0.3	0.0	-0.0
Indifference point function ln k	0.0	0.0	0.0	-0.0	-0.1	0.1
Indifference point function log k	0.0	0.0	0.0	-0.0	-0.1	0.1
Patch foraging total patch changes 0 sec	0.4	0.8	0.9	-0.8	-0.9	0.9
Patch foraging total patch changes 12 sec	0.9	1.2	1.3	-1.1	-1.0	1.0
Patch foraging total patch changes 18 sec	0.0	0.1	0.1	-0.3	-0.2	0.2
Patch foraging total patch changes 24 sec	0.7	1.1	1.4	-1.2	-1.0	1.0
Patch foraging total patch changes 6 sec	0.1	0.1	0.1	-0.4	-0.3	0.3
Patch foraging time to switch 0 sec	0.0	0.0	0.0	-0.1	-0.2	0.2
Patch foraging water rate 0 sec	0.0	0.0	0.0	0.0	0.1	-0.1
Patch foraging water rate 12 sec	1.0	2.1	2.2	-1.5	-1.4	1.4
Patch foraging water rate 18 sec	0.6	0.9	1.0	-1.0	-0.9	0.9
Patch foraging water rate 24 sec	2.4	3.4	3.5	-1.8	-1.9	1.9
Patch foraging water rate 6 sec	1.2	1.7	1.8	-1.4	-1.3	1.3
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.1	-0.3	0.1	-0.1
Distance traveled before self-admin	0.0	0.0	0.0	-0.0	-0.1	0.1
Distance traveled after self-admin	1.6	2.0	2.1	-1.5	-1.4	1.4
Extensor digitorum longus weight	4.5	17.7	18.2	4.3	4.2	-4.2
Bone: elastic displacement	0.4	0.5	0.7	0.8	0.6	-0.6
Bone: elastic work	0.8	1.0	1.3	1.1	0.9	-0.9
Bone: endosteal estimation	0.7	1.6	1.7	1.3	1.3	-1.3
Bone: endosteal perimeter	0.3	0.7	0.7	0.8	0.8	-0.8
Epididymis fat weight	17.1	58.7	58.8	-7.6	-7.7	7.7
Delta time in closed arm before/after self-admin	0.0	0.0	0.0	0.1	0.2	-0.2
Delta time in open arm before/after self-admin	0.1	0.1	0.1	0.3	0.3	-0.3
Diff in mean of infusions in LGA sessions	0.0	0.0	0.0	0.1	0.0	-0.0
Delay discount exponential model param	0.3	0.4	0.6	-0.8	-0.5	0.5
Extinction: sum of active levers before priming	0.2	0.3	0.5	0.7	0.4	-0.4
Active lever presses in extinction session 6	0.3	0.3	0.3	0.6	0.6	-0.6
Bone: final force	0.2	0.2	0.3	0.4	0.5	-0.5
Bone: final moment	0.2	0.3	0.4	0.5	0.6	-0.6
Food consumed during 24 hour testing period	0.2	0.2	0.2	0.5	0.5	-0.5
Glucose	0.2	0.3	0.4	-0.6	-0.6	0.6
Heart weight	2.8	4.3	4.7	-2.2	-2.0	2.0
Delay discount hyperbolic model param	0.2	0.2	0.4	-0.6	-0.4	0.4
Intermittent access intake day 1-15 change	0.1	0.2	0.2	0.0	0.5	-0.5
Intermittent access intake escalation	0.0	0.0	0.0	-0.2	0.2	-0.2
Intermittent access intake escalation 2	0.1	0.1	0.1	-0.1	0.3	-0.3
Intermitt. access day 1 inactive lever presses	0.3	1.2	1.3	1.1	1.1	-1.1
Intermitt. access day 15 inactive lever presses	3.8	7.9	8.3	2.6	2.9	-2.9
Intermitt. access escalation Index	0.2	0.2	0.4	-0.6	-0.4	0.4
Intermittent access day 1 total infusions	2.7	4.3	4.7	2.2	2.0	-2.0
Intermittent access day 15 total infusions	1.4	2.1	2.3	1.3	1.5	-1.5
Intermittent access terminal intake (last 3 days)	2.1	2.8	3.0	1.6	1.7	-1.7
Intermittent access total infusions	1.6	1.8	2.0	1.4	1.3	-1.3
Intermittent access day 1 locomotion	1.5	1.9	2.2	1.5	1.3	-1.3
Intermittent access day 15 total locomotion	0.1	0.1	0.2	0.4	0.4	-0.4
Intermittent access total locomotion	0.1	0.1	0.2	0.4	0.3	-0.3
Intermittent access standard deviation	0.7	1.5	1.6	1.1	1.3	-1.3
Left kidney weight	0.0	0.0	0.1	-0.2	-0.2	0.2
Right kidney weight	0.5	2.1	2.4	-1.3	-1.5	1.5
Cocaine induced anxiety	0.3	0.4	0.5	0.5	0.7	-0.7
Post-drug Anxiety	1.0	1.0	1.2	-1.1	-1.0	1.0
Baseline Anxiety	3.4	4.0	4.1	-1.9	-2.0	2.0
Tail length	0.3	1.3	1.9	-1.4	-1.0	1.0
Length with tail	1.9	8.1	8.7	-2.9	-2.8	2.8
Length without tail	0.8	2.4	2.6	-1.5	-1.6	1.6
Times rat made contact with spout	1.9	2.2	2.5	1.6	1.4	-1.4
Lifetime Intake	1.7	2.1	2.2	1.5	1.4	-1.4
Liver weight, left	3.9	6.4	6.4	-2.5	-2.5	2.5
Liver weight, right	10.1	17.6	18.0	-4.2	-4.2	4.2
Locomotor activity	0.3	0.5	0.6	-0.5	-0.7	0.7
Locomotor testing distance	0.1	0.2	0.3	0.5	0.4	-0.4
Locomotor testing rearing	0.4	0.8	0.8	0.9	0.8	-0.8
Locomotion in novel chamber	0.1	0.2	0.4	-0.6	-0.3	0.3
Locomotion in novel chamber post-restriction	3.2	5.2	5.4	-2.2	-2.3	2.3
Fecal boli incidents, locomotor time 1	0.2	0.3	0.3	0.5	0.6	-0.6
Change in fecal boli incidents, locomotor task	4.6	4.5	4.7	-2.1	-2.2	2.2
Time >=10cm from walls, locomotor time 1	0.1	0.2	0.2	-0.2	-0.5	0.5
Bouts of movement, locomotor time 1	2.1	2.4	2.4	1.5	1.6	-1.6
Total resting periods, locomotor time 1	2.5	2.8	2.8	1.6	1.7	-1.7
Rest time, locomotor task time 1	0.0	0.1	0.1	-0.3	-0.2	0.2
Distance moved, locomotor task time 1	0.9	1.4	1.5	-1.1	-1.2	1.2
Vertical activity count, locomotor time 1	0.2	0.6	0.7	-0.6	-0.8	0.8
Time >=10cm from walls, locomotor time 2	0.2	0.3	0.3	0.4	0.6	-0.6
Bouts of movement, locomotor time 2	0.0	0.0	0.0	-0.1	-0.1	0.1
Total resting periods, locomotor time 2	0.0	0.1	0.1	0.2	0.3	-0.3
Rest time, locomotor task time 2	1.3	1.7	1.7	1.3	1.3	-1.3
Distance moved, locomotor task time 2	1.1	1.4	1.4	-1.2	-1.2	1.2
Vertical activity count, locomotor time 2	0.5	0.6	0.8	-0.9	-0.8	0.8
Light reinforcement 1	3.2	7.8	7.8	2.8	2.8	-2.8
Light reinforcement 2	3.4	5.2	5.2	2.2	2.3	-2.3
Bone: marrow area	0.7	1.6	1.6	1.3	1.3	-1.3
Bone: maximum diameter	1.4	2.6	2.6	1.6	1.6	-1.6
Bone: maximum force	0.2	0.3	0.3	0.5	0.6	-0.6
Bone: maximum moment	0.3	0.4	0.5	0.7	0.7	-0.7
Mean time between licks in bursts	1.6	3.9	3.9	-1.9	-2.0	2.0
Mean num. licks in bursts	0.1	0.1	0.1	0.4	0.4	-0.4
Cd content in liver	0.0	0.0	0.0	0.1	0.1	-0.1
Co content in liver	6.4	7.5	7.6	2.8	2.7	-2.7
Cu content in liver	0.1	0.1	0.1	0.3	0.3	-0.3
Fe content in liver	0.7	0.8	0.8	0.9	0.9	-0.9
K content in liver	0.6	0.6	0.7	0.7	0.8	-0.8
Mg content in liver	0.6	0.6	0.7	0.8	0.8	-0.8
Mn content in liver	0.1	0.1	0.1	0.3	0.3	-0.3
Na content in liver	0.6	0.6	0.7	0.7	0.8	-0.8
Rb content in liver	0.0	0.0	0.0	0.1	0.1	-0.1
Se content in liver	0.1	0.1	0.2	-0.4	-0.3	0.3
Sr content in liver	0.1	0.1	0.1	-0.3	-0.4	0.4
Zn content in liver	0.7	0.8	0.9	-0.9	-0.9	0.9
Bone: minimum diameter	0.0	0.0	0.0	-0.1	-0.1	0.1
Time in familiar zone, hab. session 1	0.6	0.5	0.6	-0.8	-0.7	0.7
Time in novel zone, hab. session 1	0.8	0.8	0.9	-0.8	-0.9	0.9
Total zone transitions, hab. session 1	0.1	0.2	0.2	0.4	0.4	-0.4
Total locomotion distance, hab. session 1	0.2	0.3	0.3	0.5	0.5	-0.5
Locomotion velocity, hab. session 1	1.2	1.7	1.7	1.3	1.3	-1.3
Time in familiar zone, hab. session 2	0.0	0.0	0.0	0.1	0.2	-0.2
Time in novel zone, hab. session 2	0.7	0.7	0.8	-0.7	-0.9	0.9
Total zone transitions, hab. session 2	0.1	0.1	0.2	0.4	0.3	-0.3
Total locomotion distance, hab. session 2	0.2	0.3	0.3	0.6	0.6	-0.6
Locomotion velocity, hab. session 2	0.5	0.6	0.6	0.8	0.8	-0.8
Novel to familiar place preference ratio	1.0	1.1	1.1	-1.0	-1.1	1.1
Novelty place preference	1.7	1.8	1.9	-1.3	-1.4	1.4
Time in novel zone, NPP test	2.0	2.1	2.2	-1.4	-1.5	1.5
Total zone transitions, NPP test	1.6	2.3	2.3	1.5	1.5	-1.5
Total locomotion distance, NPP test	2.1	2.8	2.8	1.7	1.7	-1.7
Locomotion velocity, NPP test	3.4	4.8	4.9	2.2	2.2	-2.2
Intraocular pressure	6.1	8.7	9.3	-2.8	-3.0	3.0
Delta distance traveled before/after self-admin	1.4	1.5	1.9	-1.4	-1.1	1.1
Delta ambulatory time before/after self-admin	0.1	0.1	0.2	-0.4	-0.2	0.2
Parametrial fat weight	10.3	24.3	26.0	-5.1	-4.8	4.8
Pavlov. Cond. lever latency	1.9	2.4	2.4	-1.5	-1.5	1.5
Pavlov. Cond. magazine entry latency	0.1	0.1	0.1	0.3	0.3	-0.3
Pavlov. Cond. change in total contacts	0.0	0.0	0.0	0.2	0.2	-0.2
Pavlov. Cond. index score	0.8	1.0	1.0	1.0	1.0	-1.0
Pavlov. Cond. latency score	0.8	1.0	1.0	1.0	1.0	-1.0
Pavlov. Cond. lever contacts	1.3	1.5	1.5	1.2	1.2	-1.2
Pavlov. Cond. magazine entry number	0.5	0.6	0.6	-0.8	-0.8	0.8
Pavlov. Cond. intertrial magazine entries	1.1	1.3	1.5	1.2	1.1	-1.1
Pavlov. Cond. lever-magazine prob. diff.	1.5	1.8	1.9	1.4	1.3	-1.3
Pavlov. Cond. response bias	1.4	1.7	1.8	1.3	1.3	-1.3
Pavlov. Cond. lever latency	1.4	2.0	2.0	-1.4	-1.4	1.4
Pavlov. Cond. magazine entry latency	0.3	0.4	0.4	0.5	0.6	-0.6
Pavlov. Cond. change in total contacts	0.6	1.0	1.1	1.0	1.0	-1.0
Pavlov. Cond. index score	1.2	1.6	1.6	1.2	1.3	-1.3
Pavlov. Cond. latency score	1.2	1.6	1.7	1.2	1.3	-1.3
Pavlov. Cond. lever contacts	1.0	1.4	1.4	1.2	1.2	-1.2
Pavlov. Cond. magazine entry number	0.2	0.3	0.3	-0.4	-0.5	0.5
Pavlov. Cond. intertrial magazine entries	3.5	5.3	5.4	-2.3	-2.3	2.3
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.1	1.1	1.0	1.1	-1.1
Pavlov. Cond. response bias	1.7	2.3	2.3	1.5	1.5	-1.5
Time in closed arm before self-admin	0.9	1.2	1.2	-1.1	-1.1	1.1
Time in closed arm after self-admin	1.5	1.6	1.6	-1.3	-1.3	1.3
Time in open arm before self-admin	0.1	0.1	0.1	0.4	0.1	-0.1
Time in open arm after self-admin	1.5	1.7	1.8	1.3	1.3	-1.3
Bone: periosteal estimation	1.2	2.5	2.5	1.6	1.6	-1.6
Bone: periosteal perimeter	0.6	1.0	1.0	1.0	1.0	-1.0
Bone: post-yield work	0.9	1.3	1.4	1.1	1.2	-1.2
Progressive ratio test 1 active lever presses	0.8	1.0	1.3	1.2	0.9	-0.9
Progressive ratio test 1 breakpoint	0.8	1.0	1.4	1.2	0.9	-0.9
Progressive ratio test 1 inactive lever presses	2.4	3.5	3.6	1.8	1.9	-1.9
Progressive ratio test 2 active lever presses	0.1	0.1	0.1	0.3	0.3	-0.3
Progressive ratio test 2 breakpoint	0.0	0.0	0.0	0.2	0.2	-0.2
Progressive ratio test 2 inactive lever presses	1.0	1.7	1.9	1.1	1.4	-1.4
Incentive Sensitization - Responses	0.1	0.2	0.2	0.2	0.5	-0.5
Incentive Sensitization - Breakpoint	0.1	0.1	0.1	0.0	0.4	-0.4
Sum of active levers in priming session hrs 5-6	0.8	0.7	0.8	0.9	0.8	-0.8
Progressive ratio	0.0	0.0	0.1	-0.3	-0.1	0.1
Food seeking constrained by brief footshock	3.1	3.7	4.0	1.8	2.0	-2.0
Seeking ratio, punishment vs. effort	0.4	0.5	0.6	0.8	0.7	-0.7
Retroperitoneal fat weight	22.3	95.0	96.0	-9.8	-9.7	9.7
Reaction time number correct	0.5	1.0	1.0	1.0	1.0	-1.0
Reaction time mean minus median	0.0	0.0	0.0	-0.1	-0.2	0.2
Reaction time mean minus median AUC	0.0	0.1	0.1	-0.3	-0.3	0.3
Reaction time num false alarms	0.0	0.0	0.0	0.2	-0.1	0.1
Reaction time num false alarms AUC	0.0	0.0	0.1	0.3	-0.0	0.0
Reaction time trials correct on left	0.5	1.0	1.0	1.0	1.0	-1.0
Reaction time trials on left	0.5	1.0	1.1	1.0	1.0	-1.0
Reaction time mean	1.2	1.9	1.9	-1.4	-1.4	1.4
Reaction time mean AUC	1.0	1.6	1.7	-1.2	-1.3	1.3
Median of all reaction times	1.4	2.0	2.1	-1.4	-1.4	1.4
Reaction time omissions	0.0	0.1	0.1	0.3	0.2	-0.2
Reaction time false alarm rate	0.1	0.2	0.2	-0.2	-0.5	0.5
Reaction time premature initiation rate	0.2	0.3	0.3	-0.5	-0.6	0.6
Reaction time premature initiations	0.0	0.0	0.0	0.1	-0.0	0.0
Std. dev. reaction times	0.3	0.6	0.6	-0.8	-0.8	0.8
Reaction time trials completed	0.5	1.0	1.1	1.0	1.0	-1.0
Reaction time trials AUC	0.6	1.2	1.3	1.1	1.1	-1.1
Run reversals in cocaine runway, females	0.1	0.1	0.1	-0.2	-0.3	0.3
Run reversals in cocaine runway, males	0.0	0.0	0.1	0.3	0.1	-0.1
Latency to leave start box in cocaine runway	0.7	0.8	1.0	0.7	1.0	-1.0
Latency to leave start box in cocaine runway, F	0.3	0.3	0.4	0.6	0.6	-0.6
Latency to leave start box in cocaine runway, M	0.2	0.2	0.3	0.0	0.5	-0.5
Std. dev. time between licks in bursts	0.0	0.0	0.1	-0.2	-0.1	0.1
Total sessions with >9 infusions	0.4	0.5	0.5	0.6	0.7	-0.7
Short access day 1 total inactive lever presses	6.9	9.0	9.0	3.0	3.0	-3.0
Short access day 10 total inactive lever presses	1.5	3.7	4.2	2.0	1.9	-1.9
Short access day 1 total infusions	3.1	4.1	4.3	1.9	2.1	-2.1
Short access day 10 total infusions	1.5	1.9	2.2	1.5	1.3	-1.3
Short access total infusions	0.7	0.9	0.9	0.9	1.0	-1.0
Short access day 1 locomotion	2.2	2.7	2.9	1.6	1.7	-1.7
Short access day 10 total locomotion	0.8	1.5	1.9	1.4	1.2	-1.2
Short access total locomotion	0.0	0.0	0.1	0.2	0.1	-0.1
One hour access (0.3 mA shock)	0.9	1.1	1.1	0.9	1.1	-1.1
Compulsive drug intake	0.6	0.7	0.7	-0.7	-0.9	0.9
One hour access (shock baseline)	1.3	2.0	2.1	1.3	1.5	-1.5
Social response proportion	0.3	0.4	0.5	-0.7	-0.6	0.6
Social responses	0.0	0.1	0.1	-0.3	-0.2	0.2
Social time	0.3	0.4	0.8	-0.9	-0.5	0.5
Soleus weight	4.7	13.8	14.9	3.9	3.6	-3.6
Bone: stiffness	0.0	0.1	0.1	0.2	0.3	-0.3
Tibialis anterior weight	3.8	12.8	13.4	3.7	3.5	-3.5
Time to tail flick, vehicle, before self-admin	1.5	1.6	1.6	-1.2	-1.3	1.3
Time to tail flick, vehicle, after self-admin	4.1	5.4	5.6	-2.2	-2.4	2.4
Time to tail flick, test, before self-admin	0.0	0.0	0.1	0.2	0.1	-0.1
Time to tail flick, test, after self-admin	0.1	0.1	0.1	0.3	0.3	-0.3
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.1	-0.2	-0.2	0.2
Delta time to tail flick, test, before/after SA	1.7	1.7	1.8	1.3	1.3	-1.3
Tibia length	2.6	7.2	7.7	-2.8	-2.6	2.6
Ambulatory time before self-admin	0.0	0.0	0.0	0.1	0.0	-0.0
Ambulatory time after self-admin	1.0	1.1	1.3	-1.1	-1.0	1.0
Bone: tissue strength	0.9	0.9	1.0	-0.9	-1.0	1.0
Total heroin consumption	2.9	3.4	3.9	2.0	1.8	-1.8
Bone: trabecular number	3.9	6.4	6.4	2.5	2.5	-2.5
Bone: trabecular spacing	3.3	4.4	4.5	-2.1	-2.1	2.1
Bone: trabecular thickness	0.9	1.1	1.2	1.0	1.1	-1.1
Bone: trabecular tissue density	0.4	0.6	0.6	0.6	0.8	-0.8
Water consumed over 24 hours	0.6	0.7	0.8	0.9	0.8	-0.8
Number of responses in last shaping day	0.1	0.1	0.1	0.1	0.4	-0.4