Hub : Genes

Pnlip

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 OFC gene expression Pnlip 0.18 0.11 3.3e-03 0.02 0.09 0.04 0.05 1.0e-01 3.8e-03 3.9e-02 2.6e-02
2 Eye gene expression Pnlip 0.41 0.18 4.2e-03 0.08 0.1 0.02 0.07 2.4e-02 1.3e-02 1.6e-01 3.6e-02
3 Brain gene expression Pnlip 0.03 0.03 5.6e-03 0.03 0.02 0.03 0.02 1.1e-03 8.2e-03 2.0e-03 2.7e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bone: apparent density2.03.34.01.6-1.9-2.0
Area under the delay curve1.21.22.21.5-1.1-0.5
BMI with tail4.414.420.04.5-3.7-3.1
BMI without tail3.87.89.93.1-2.7-2.5
Body weight5.020.827.95.3-4.5-3.8
Weight adjusted by age0.91.12.41.5-0.8-0.4
Bone surface0.91.52.21.0-1.2-1.5
Bone volume1.93.33.51.8-1.8-1.9
Breakpoint value in progressive ratio session3.43.84.21.9-2.0-1.8
Number of licking bursts0.50.61.30.2-0.6-1.2
Context. condit. distance diff. score0.91.11.4-1.20.90.9
Locomotion velocity, session 10.20.20.2-0.50.40.4
Locomotion distance, session 11.82.32.6-1.51.61.4
Locomotion velocity, session 23.74.34.8-2.22.21.9
Locomotion distance, session 21.31.82.3-1.31.51.1
Locomotion velocity, session 31.21.41.7-1.31.31.0
Locomotion distance, session 32.62.93.2-1.81.81.5
Stereotopy head waving bouts, day 30.00.10.2-0.00.10.4
Stereotopy head waving duration, day 30.00.00.00.2-0.20.1
Locomotion velocity, session 70.20.20.2-0.30.50.4
Locomotion distance, session 70.70.91.0-0.91.01.0
Stereotopy head waving bouts, day 70.20.20.40.3-0.4-0.6
Stereotopy head waving duration, day 71.11.41.81.3-1.1-1.1
Locomotion velocity, session 81.41.73.1-1.81.20.8
Locomotion distance, session 83.85.68.2-2.92.41.7
Degree of sensitization distance0.90.91.01.0-1.0-0.8
Degree of sensitization stereotypy0.70.71.00.8-0.7-1.0
Conditioned locomotion0.00.00.10.3-0.1-0.2
Cocaine response after cond. corrected6.16.87.1-2.52.72.7
Cocaine response after cond. not corrected4.85.35.4-2.32.32.3
Cocaine response before conditioning1.11.31.80.8-1.2-1.3
Saline control response0.10.10.2-0.10.30.5
Bone: connectivity density0.61.01.50.6-1.0-1.2
Bone: cortical apparent density4.55.96.4-2.22.52.5
Bone: cortical area2.43.64.12.0-1.7-2.0
Bone: cortical porosity1.01.11.60.8-1.1-1.3
Bone: cortical porosity2.02.22.71.2-1.5-1.6
Bone: cortical thickness0.10.20.40.4-0.2-0.6
Bone: cortical thickness0.00.00.00.10.20.2
Bone: cortical tissue density4.76.26.7-2.32.52.6
Condit. Reinf. active minus inactive responses0.60.71.5-1.20.70.3
Condit. Reinf. active-inactive response ratio0.10.20.4-0.60.30.0
Condit. Reinf. active responses0.20.20.5-0.70.2-0.3
Condit. Reinf. inactive responses0.20.20.6-0.1-0.3-0.8
Incentive salience index mean1.21.42.7-1.61.10.6
Condit. Reinf. lever presses0.60.81.4-1.20.90.5
Condit. Reinf. active minus inactive responses3.03.74.01.9-2.0-1.9
Condit. Reinf. active-inactive response ratio1.71.81.91.4-1.4-1.3
Condit. Reinf. active responses4.05.65.82.4-2.4-2.3
Condit. Reinf. inactive responses1.51.81.91.3-1.4-1.4
Condit. Reinf. lever presses1.31.71.81.3-1.3-1.3
Condit. Reinf. lever reinforcers received2.83.94.11.9-2.0-2.0
Conditioned reinforcement - actives3.43.43.9-1.92.01.6
Conditioned reinforcement - inactives0.20.20.30.4-0.4-0.5
Conditioned locomotion3.03.74.0-2.02.01.7
Patch foraging indifference point 0 sec1.11.82.51.6-1.3-1.1
Patch foraging indifference point AUC1.61.82.41.5-1.2-1.2
Delay disc. indifference point, 0s delay0.10.10.30.10.30.5
Delay disc. indifference point, 16s delay0.60.61.01.0-0.8-0.4
Delay disc. indifference point, 2s delay0.20.20.60.20.20.7
Delay disc. indifference point, 24s delay1.21.21.31.1-1.1-0.9
Delay disc. indifference point, 4s delay0.30.40.60.8-0.6-0.3
Delay disc. indifference point, 8s delay1.41.43.01.7-1.1-0.3
Indifference point function ln k0.71.01.2-1.10.91.0
Indifference point function log k0.71.01.2-1.10.91.0
Patch foraging total patch changes 0 sec1.52.43.21.8-1.5-1.3
Patch foraging total patch changes 12 sec2.43.13.51.9-1.7-1.7
Patch foraging total patch changes 18 sec4.55.87.22.7-2.3-2.2
Patch foraging total patch changes 24 sec4.04.96.22.5-2.2-1.9
Patch foraging total patch changes 6 sec3.14.65.72.4-2.0-2.0
Patch foraging time to switch 0 sec0.10.10.1-0.30.20.4
Patch foraging water rate 0 sec0.20.30.30.6-0.5-0.4
Patch foraging water rate 12 sec1.52.32.41.5-1.5-1.5
Patch foraging water rate 18 sec0.20.20.4-0.20.40.6
Patch foraging water rate 24 sec0.10.10.20.30.10.4
Patch foraging water rate 6 sec0.00.10.10.30.00.3
Seeking ratio, delayed vs. immediate footshock2.02.43.1-1.81.61.2
Distance traveled before self-admin2.22.43.9-1.11.42.0
Distance traveled after self-admin1.92.23.0-1.21.41.7
Extensor digitorum longus weight1.55.97.22.7-2.5-2.1
Bone: elastic displacement0.00.00.10.4-0.10.1
Bone: elastic work0.20.30.5-0.10.50.7
Bone: endosteal estimation0.81.72.21.5-1.3-1.1
Bone: endosteal perimeter1.73.65.92.4-1.8-1.3
Epididymis fat weight9.121.223.84.9-4.5-4.4
Delta time in closed arm before/after self-admin1.21.21.5-1.21.11.0
Delta time in open arm before/after self-admin3.73.64.11.7-1.9-2.0
Diff in mean of infusions in LGA sessions1.61.72.21.0-1.5-1.4
Delay discount exponential model param1.31.42.5-1.61.20.5
Extinction: sum of active levers before priming1.21.21.41.0-1.2-1.1
Active lever presses in extinction session 60.80.70.80.8-0.9-0.9
Bone: final force0.50.81.01.0-0.7-0.9
Bone: final moment0.61.01.21.1-0.8-1.0
Food consumed during 24 hour testing period0.40.51.0-1.00.60.2
Glucose3.04.46.02.4-2.1-1.7
Heart weight0.30.40.80.9-0.6-0.3
Delay discount hyperbolic model param0.91.01.9-1.41.00.3
Intermittent access intake day 1-15 change1.71.72.71.6-1.3-0.9
Intermittent access intake escalation0.20.20.50.7-0.20.1
Intermittent access intake escalation 20.10.10.20.4-0.10.1
Intermitt. access day 1 inactive lever presses5.45.87.02.6-2.4-2.1
Intermitt. access day 15 inactive lever presses0.80.91.31.1-0.9-0.8
Intermitt. access escalation Index0.20.10.4-0.10.20.6
Intermittent access day 1 total infusions0.00.00.0-0.10.20.1
Intermittent access day 15 total infusions0.10.10.40.6-0.10.1
Intermittent access terminal intake (last 3 days)0.10.20.40.6-0.3-0.1
Intermittent access total infusions0.00.10.10.30.20.2
Intermittent access day 1 locomotion0.70.81.2-0.50.91.1
Intermittent access day 15 total locomotion1.92.03.01.7-1.3-1.2
Intermittent access total locomotion0.30.40.6-0.20.80.7
Intermittent access standard deviation1.41.51.81.4-1.2-1.1
Left kidney weight1.02.83.4-1.21.81.8
Right kidney weight0.41.22.0-0.31.21.4
Cocaine induced anxiety4.14.77.0-2.62.21.5
Post-drug Anxiety1.01.11.8-1.31.00.5
Baseline Anxiety5.45.87.32.7-2.4-2.1
Tail length0.51.61.81.2-1.3-1.3
Length with tail0.72.43.01.7-1.5-1.3
Length without tail0.40.91.31.1-0.9-0.7
Times rat made contact with spout0.00.00.0-0.20.2-0.1
Lifetime Intake0.10.10.2-0.00.50.4
Liver weight, left3.35.36.92.6-2.3-1.9
Liver weight, right4.47.310.03.2-2.6-2.2
Locomotor activity0.00.00.10.3-0.00.0
Locomotor testing distance0.50.81.4-0.40.91.2
Locomotor testing rearing0.20.30.70.30.20.8
Locomotion in novel chamber1.21.51.6-1.21.21.2
Locomotion in novel chamber post-restriction3.54.24.6-2.12.11.9
Fecal boli incidents, locomotor time 10.20.20.30.5-0.3-0.4
Change in fecal boli incidents, locomotor task0.20.10.3-0.6-0.1-0.4
Time >=10cm from walls, locomotor time 10.30.30.9-0.90.40.1
Bouts of movement, locomotor time 11.81.92.61.6-1.3-1.2
Total resting periods, locomotor time 10.80.91.41.2-0.9-0.8
Rest time, locomotor task time 11.41.51.9-1.11.41.2
Distance moved, locomotor task time 10.10.10.20.5-0.5-0.2
Vertical activity count, locomotor time 10.10.10.1-0.40.20.4
Time >=10cm from walls, locomotor time 20.20.20.5-0.70.30.0
Bouts of movement, locomotor time 20.00.00.10.2-0.10.2
Total resting periods, locomotor time 20.10.10.20.4-0.20.2
Rest time, locomotor task time 20.10.10.30.20.20.5
Distance moved, locomotor task time 20.10.10.1-0.40.30.1
Vertical activity count, locomotor time 20.10.10.3-0.50.3-0.0
Light reinforcement 10.40.71.2-1.10.80.5
Light reinforcement 21.41.82.8-1.71.40.8
Bone: marrow area0.81.82.31.5-1.3-1.1
Bone: maximum diameter4.27.89.43.1-2.7-2.6
Bone: maximum force0.10.20.40.5-0.4-0.6
Bone: maximum moment0.20.30.40.6-0.5-0.7
Mean time between licks in bursts0.71.01.70.6-1.0-1.3
Mean num. licks in bursts0.70.91.7-0.40.91.3
Cd content in liver1.11.22.6-1.61.00.4
Co content in liver1.92.32.6-1.61.61.3
Cu content in liver0.10.20.2-0.30.50.5
Fe content in liver0.20.20.6-0.0-0.3-0.8
K content in liver0.10.10.10.4-0.2-0.1
Mg content in liver0.60.71.31.1-0.8-0.4
Mn content in liver0.00.00.0-0.00.10.2
Na content in liver1.01.11.61.3-1.1-0.6
Rb content in liver0.40.50.60.8-0.7-0.5
Se content in liver0.10.10.3-0.0-0.1-0.5
Sr content in liver2.52.32.5-1.41.51.6
Zn content in liver2.12.33.6-1.11.41.9
Bone: minimum diameter1.52.93.51.9-1.6-1.6
Time in familiar zone, hab. session 10.10.10.20.20.00.5
Time in novel zone, hab. session 10.80.81.30.7-0.8-1.1
Total zone transitions, hab. session 10.00.10.10.10.30.3
Total locomotion distance, hab. session 10.10.10.2-0.40.1-0.4
Locomotion velocity, hab. session 10.10.20.4-0.70.3-0.3
Time in familiar zone, hab. session 22.12.22.41.3-1.5-1.5
Time in novel zone, hab. session 21.61.61.8-1.11.31.3
Total zone transitions, hab. session 20.10.10.10.30.20.3
Total locomotion distance, hab. session 20.00.00.0-0.10.00.1
Locomotion velocity, hab. session 20.00.00.0-0.00.00.1
Novel to familiar place preference ratio0.40.40.80.1-0.5-0.9
Novelty place preference0.30.30.60.2-0.5-0.8
Time in novel zone, NPP test1.01.01.60.6-1.0-1.3
Total zone transitions, NPP test0.00.10.1-0.10.30.2
Total locomotion distance, NPP test0.30.40.8-0.90.60.3
Locomotion velocity, NPP test1.01.52.2-1.51.20.9
Intraocular pressure2.83.94.22.0-1.9-2.1
Delta distance traveled before/after self-admin0.00.00.0-0.10.10.2
Delta ambulatory time before/after self-admin0.00.00.00.0-0.1-0.2
Parametrial fat weight9.718.821.74.7-4.3-4.0
Pavlov. Cond. lever latency0.50.70.90.9-0.9-0.6
Pavlov. Cond. magazine entry latency0.00.10.1-0.40.2-0.0
Pavlov. Cond. change in total contacts0.00.00.0-0.0-0.00.1
Pavlov. Cond. index score0.00.00.0-0.10.0-0.1
Pavlov. Cond. latency score0.00.00.0-0.20.2-0.0
Pavlov. Cond. lever contacts0.00.00.0-0.20.1-0.0
Pavlov. Cond. magazine entry number0.10.10.1-0.30.30.3
Pavlov. Cond. intertrial magazine entries0.40.50.8-0.90.60.3
Pavlov. Cond. lever-magazine prob. diff.0.00.00.1-0.0-0.1-0.2
Pavlov. Cond. response bias0.10.10.1-0.40.30.2
Pavlov. Cond. lever latency1.62.12.6-1.31.41.6
Pavlov. Cond. magazine entry latency1.11.31.51.2-1.2-1.0
Pavlov. Cond. change in total contacts1.41.92.01.4-1.4-1.3
Pavlov. Cond. index score1.62.02.11.5-1.4-1.4
Pavlov. Cond. latency score1.41.81.81.4-1.3-1.3
Pavlov. Cond. lever contacts0.91.31.51.1-1.1-1.2
Pavlov. Cond. magazine entry number0.80.91.1-1.01.00.9
Pavlov. Cond. intertrial magazine entries0.20.20.30.5-0.4-0.6
Pavlov. Cond. lever-magazine prob. diff.1.21.51.71.3-1.2-1.2
Pavlov. Cond. response bias1.52.12.41.4-1.4-1.6
Time in closed arm before self-admin0.10.10.20.4-0.00.5
Time in closed arm after self-admin1.21.21.9-0.81.01.4
Time in open arm before self-admin0.91.02.2-1.50.90.4
Time in open arm after self-admin1.11.22.10.6-1.1-1.5
Bone: periosteal estimation1.42.93.61.9-1.6-1.6
Bone: periosteal perimeter3.66.19.33.0-2.2-2.0
Bone: post-yield work0.30.41.0-0.2-0.4-1.0
Progressive ratio test 1 active lever presses0.10.10.30.00.40.6
Progressive ratio test 1 breakpoint0.10.10.20.10.20.5
Progressive ratio test 1 inactive lever presses0.00.00.00.2-0.2-0.1
Progressive ratio test 2 active lever presses0.50.51.41.2-0.5-0.0
Progressive ratio test 2 breakpoint0.70.81.91.4-0.7-0.1
Progressive ratio test 2 inactive lever presses0.40.40.60.8-0.6-0.6
Incentive Sensitization - Responses1.92.03.81.9-1.3-0.6
Incentive Sensitization - Breakpoint2.32.44.22.1-1.5-0.8
Sum of active levers in priming session hrs 5-61.21.21.50.9-1.2-1.2
Progressive ratio0.70.91.6-1.30.90.5
Food seeking constrained by brief footshock0.10.20.3-0.60.30.2
Seeking ratio, punishment vs. effort0.10.10.20.5-0.20.3
Retroperitoneal fat weight8.427.733.95.8-5.1-4.8
Reaction time number correct0.81.22.21.5-1.0-0.6
Reaction time mean minus median1.01.32.11.5-1.1-0.7
Reaction time mean minus median AUC0.50.61.51.2-0.60.0
Reaction time num false alarms0.60.80.8-0.90.80.9
Reaction time num false alarms AUC0.81.11.4-1.01.01.2
Reaction time trials correct on left0.81.22.21.5-1.0-0.6
Reaction time trials on left1.01.42.51.6-1.1-0.7
Reaction time mean0.50.71.51.2-0.8-0.1
Reaction time mean AUC0.50.61.41.2-0.70.0
Median of all reaction times0.20.30.70.8-0.40.4
Reaction time omissions1.82.43.41.8-1.6-1.2
Reaction time false alarm rate1.21.72.4-1.51.21.1
Reaction time premature initiation rate0.60.71.0-0.81.00.8
Reaction time premature initiations0.10.10.20.10.40.4
Std. dev. reaction times1.52.13.61.9-1.4-0.8
Reaction time trials completed1.01.42.51.6-1.1-0.7
Reaction time trials AUC0.91.42.41.6-1.1-0.7
Run reversals in cocaine runway, females0.20.20.30.6-0.5-0.3
Run reversals in cocaine runway, males1.00.91.1-1.01.10.8
Latency to leave start box in cocaine runway0.70.81.41.2-1.0-0.3
Latency to leave start box in cocaine runway, F0.70.81.11.1-1.0-0.5
Latency to leave start box in cocaine runway, M0.20.20.30.6-0.10.5
Std. dev. time between licks in bursts0.20.20.6-0.70.2-0.1
Total sessions with >9 infusions0.70.81.1-0.41.01.0
Short access day 1 total inactive lever presses0.00.00.0-0.2-0.0-0.2
Short access day 10 total inactive lever presses0.80.91.11.1-0.9-0.8
Short access day 1 total infusions0.30.40.5-0.40.70.7
Short access day 10 total infusions1.01.11.4-0.81.11.2
Short access total infusions0.60.60.8-0.60.90.9
Short access day 1 locomotion0.10.10.10.4-0.00.3
Short access day 10 total locomotion0.10.20.3-0.10.40.6
Short access total locomotion2.12.23.4-0.91.61.8
One hour access (0.3 mA shock)1.72.02.41.5-1.4-1.3
Compulsive drug intake0.30.30.60.3-0.6-0.8
One hour access (shock baseline)0.10.10.30.6-0.10.1
Social response proportion0.50.51.0-0.40.71.0
Social responses0.91.21.91.4-1.0-0.8
Social time0.20.30.50.7-0.10.6
Soleus weight0.82.35.62.4-1.2-0.1
Bone: stiffness0.10.20.40.3-0.2-0.6
Tibialis anterior weight1.24.15.82.4-2.1-1.5
Time to tail flick, vehicle, before self-admin0.40.40.60.5-0.5-0.8
Time to tail flick, vehicle, after self-admin0.00.00.0-0.00.20.1
Time to tail flick, test, before self-admin3.13.03.4-1.51.81.8
Time to tail flick, test, after self-admin1.91.92.21.5-1.3-1.4
Delta time to tail flick, vehicle, before/after SA0.20.20.40.6-0.5-0.2
Delta time to tail flick, test, before/after SA3.93.54.01.8-1.8-2.0
Tibia length0.00.00.1-0.00.30.1
Ambulatory time before self-admin1.21.21.9-0.81.11.4
Ambulatory time after self-admin1.21.31.8-0.91.11.4
Bone: tissue strength0.00.00.10.2-0.3-0.2
Total heroin consumption3.03.53.61.9-1.9-1.9
Bone: trabecular number1.82.83.31.4-1.7-1.8
Bone: trabecular spacing0.00.10.1-0.30.30.0
Bone: trabecular thickness3.03.54.62.1-1.9-1.6
Bone: trabecular tissue density0.91.22.3-0.51.01.5
Water consumed over 24 hours0.70.80.9-0.91.00.9
Number of responses in last shaping day0.10.10.2-0.30.50.3