Hub : Genes

Ints4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose mRNA stability Ints4 0.03 0.02 4.2e-03 0.01 0.01 0 0.01 2.1e-02 1.5e-02 1.9e-01 5.4e-02
2 Brain gene expression Ints4 0.05 0.04 8.3e-05 0.02 0.03 0.01 0.03 5.3e-03 5.0e-04 3.5e-02 2.0e-03
3 NAcc gene expression Ints4 0.04 0.03 2.6e-04 0.01 0.02 0.02 0.02 8.0e-03 4.4e-03 2.4e-03 3.6e-03
4 LHb gene expression Ints4 0.31 0.16 4.7e-04 0.12 0.08 0.09 0.11 8.0e-04 6.1e-03 3.2e-03 1.6e-03
5 Brain mRNA stability Ints4 0.15 0.09 2.5e-12 0.12 0.13 0.13 0.13 1.1e-11 2.2e-12 2.8e-12 3.2e-12
6 Adipose gene expression Ints4 0.03 0.02 3.5e-03 0.01 0.01 0.01 0.01 1.6e-02 7.1e-02 2.3e-02 3.1e-02
7 Liver mRNA stability Ints4 0.11 0.06 1.9e-12 0.08 0.09 0.08 0.08 2.6e-09 8.4e-10 1.5e-09 2.0e-09
8 Liver gene expression Ints4 0.5 0.14 0.0e+00 0.22 0.34 0.33 0.34 1.9e-24 2.5e-38 2.6e-37 9.7e-39

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.00.10.3-0.1-0.1-0.1-0.30.20.2-0.4-0.5
Area under the delay curve0.91.01.91.1-1.1-1.00.91.01.40.60.4
BMI with tail0.82.46.1-1.01.62.2-0.8-1.9-2.5-0.30.5
BMI without tail3.77.518.1-2.13.03.4-1.2-3.6-4.3-0.01.5
Body weight1.45.712.8-1.42.53.4-1.1-3.2-3.60.21.6
Weight adjusted by age0.50.62.20.3-0.1-0.00.6-0.1-0.51.31.5
Bone surface1.42.43.11.7-1.7-1.71.61.61.11.61.2
Bone volume0.81.31.81.3-1.2-1.11.21.00.61.31.2
Breakpoint value in progressive ratio session0.10.10.40.3-0.5-0.10.10.60.0-0.0-0.3
Number of licking bursts2.53.03.7-1.81.91.9-1.8-1.8-1.7-1.6-1.2
Context. condit. distance diff. score3.34.06.22.1-2.4-2.42.02.51.51.70.9
Locomotion velocity, session 10.80.81.70.7-1.0-1.10.61.21.30.1-0.4
Locomotion distance, session 10.50.61.00.7-0.8-1.01.00.91.00.50.2
Locomotion velocity, session 20.60.70.90.9-0.9-0.80.90.90.50.90.7
Locomotion distance, session 20.00.00.20.10.10.50.1-0.2-0.0-0.00.2
Locomotion velocity, session 30.30.40.60.6-0.7-0.80.50.70.70.40.2
Locomotion distance, session 32.22.43.81.6-1.9-1.91.51.91.51.10.4
Stereotopy head waving bouts, day 33.13.75.6-2.42.31.8-2.3-2.1-1.3-1.6-1.2
Stereotopy head waving duration, day 30.30.40.7-0.50.50.7-0.8-0.60.2-0.8-0.7
Locomotion velocity, session 70.40.40.70.7-0.7-0.60.60.80.80.40.2
Locomotion distance, session 70.91.21.81.2-1.1-0.81.31.10.31.31.1
Stereotopy head waving bouts, day 70.10.20.4-0.1-0.3-0.5-0.30.50.6-0.2-0.6
Stereotopy head waving duration, day 70.30.30.90.5-0.6-0.80.30.60.90.40.1
Locomotion velocity, session 86.27.411.23.3-3.4-2.72.73.32.52.01.1
Locomotion distance, session 81.52.23.01.7-1.7-1.61.61.71.31.30.8
Degree of sensitization distance0.80.82.0-0.50.90.90.1-1.1-1.40.41.1
Degree of sensitization stereotypy1.92.13.61.3-1.7-1.91.01.91.70.90.1
Conditioned locomotion0.10.10.30.2-0.20.1-0.10.10.5-0.4-0.5
Cocaine response after cond. corrected0.10.10.30.3-0.3-0.30.50.30.00.60.5
Cocaine response after cond. not corrected0.20.20.60.2-0.4-0.70.40.50.40.30.1
Cocaine response before conditioning0.40.51.3-0.70.3-0.7-0.80.10.5-0.9-1.2
Saline control response0.50.71.90.9-0.30.01.1-0.2-0.41.01.4
Bone: connectivity density0.50.81.70.6-1.0-1.30.31.31.30.1-0.5
Bone: cortical apparent density0.30.40.6-0.50.60.8-0.5-0.8-0.8-0.5-0.2
Bone: cortical area0.60.92.30.9-0.5-0.11.10.3-0.81.31.5
Bone: cortical porosity0.30.31.0-0.2-0.0-0.7-0.30.21.0-0.4-0.6
Bone: cortical porosity0.30.30.7-0.50.2-0.6-0.50.10.9-0.5-0.7
Bone: cortical thickness0.10.21.2-0.30.40.5-0.1-0.3-1.1-0.00.2
Bone: cortical thickness1.31.52.51.1-1.2-1.61.61.30.71.20.9
Bone: cortical tissue density0.30.40.6-0.50.70.7-0.5-0.8-0.7-0.5-0.3
Condit. Reinf. active minus inactive responses0.70.83.1-0.00.50.80.4-0.8-1.80.61.2
Condit. Reinf. active-inactive response ratio0.60.62.3-0.10.60.60.2-0.9-1.50.51.0
Condit. Reinf. active responses0.70.83.4-0.40.71.10.0-0.9-1.80.10.7
Condit. Reinf. inactive responses0.10.10.4-0.20.20.4-0.1-0.2-0.7-0.1-0.0
Incentive salience index mean0.40.51.60.4-0.00.20.8-0.2-1.00.91.3
Condit. Reinf. lever presses0.50.70.90.9-0.9-0.61.00.80.50.90.8
Condit. Reinf. active minus inactive responses3.94.88.52.4-1.8-1.92.91.30.62.82.9
Condit. Reinf. active-inactive response ratio2.42.54.31.8-1.5-1.22.11.30.61.91.8
Condit. Reinf. active responses4.46.112.52.6-1.8-2.03.21.10.63.33.5
Condit. Reinf. inactive responses0.91.13.90.7-0.2-0.61.1-0.30.11.52.0
Condit. Reinf. lever presses9.412.718.44.3-3.7-3.34.22.92.83.73.3
Condit. Reinf. lever reinforcers received5.07.113.02.8-2.1-2.23.41.40.83.43.6
Conditioned reinforcement - actives3.33.37.01.4-1.9-2.71.22.42.11.30.3
Conditioned reinforcement - inactives0.10.10.4-0.2-0.00.2-0.60.20.5-0.2-0.5
Conditioned locomotion2.32.85.41.3-1.9-2.20.82.32.11.0-0.0
Patch foraging indifference point 0 sec1.11.83.21.7-1.3-1.21.80.80.41.51.6
Patch foraging indifference point AUC0.20.20.40.4-0.2-0.20.60.2-0.40.60.7
Delay disc. indifference point, 0s delay0.40.40.80.4-0.4-0.80.60.50.30.90.8
Delay disc. indifference point, 16s delay0.70.72.41.0-1.0-0.70.70.81.50.0-0.2
Delay disc. indifference point, 2s delay0.70.81.20.9-1.0-1.10.61.00.80.80.5
Delay disc. indifference point, 24s delay0.10.10.20.4-0.30.30.10.10.5-0.2-0.3
Delay disc. indifference point, 4s delay1.31.42.11.3-1.2-0.91.20.90.81.41.3
Delay disc. indifference point, 8s delay1.31.42.81.3-1.3-1.11.11.21.70.70.4
Indifference point function ln k0.40.62.60.7-0.8-0.70.40.71.6-0.1-0.3
Indifference point function log k0.40.62.60.7-0.8-0.70.40.71.6-0.1-0.3
Patch foraging total patch changes 0 sec1.11.83.11.7-1.3-1.11.80.90.41.51.4
Patch foraging total patch changes 12 sec0.50.71.90.6-0.4-0.40.90.3-0.61.21.4
Patch foraging total patch changes 18 sec1.21.63.31.3-0.9-1.01.70.60.01.71.8
Patch foraging total patch changes 24 sec0.70.92.10.6-0.4-0.91.20.3-0.81.31.5
Patch foraging total patch changes 6 sec0.00.10.20.5-0.3-0.10.30.10.00.00.1
Patch foraging time to switch 0 sec2.64.16.2-2.52.01.9-2.5-1.6-0.9-2.2-2.0
Patch foraging water rate 0 sec2.03.24.52.1-1.9-1.82.11.71.11.91.4
Patch foraging water rate 12 sec1.31.93.51.9-1.6-1.11.61.31.21.20.9
Patch foraging water rate 18 sec0.81.12.11.4-1.1-0.81.30.70.41.21.1
Patch foraging water rate 24 sec1.01.52.71.6-1.7-1.00.91.51.40.60.0
Patch foraging water rate 6 sec0.71.01.61.1-1.2-1.10.91.11.30.40.0
Seeking ratio, delayed vs. immediate footshock0.00.10.2-0.30.0-0.3-0.40.20.1-0.1-0.3
Distance traveled before self-admin0.10.10.2-0.30.30.2-0.2-0.3-0.4-0.3-0.1
Distance traveled after self-admin1.01.22.4-1.11.00.8-1.2-0.8-0.2-1.5-1.4
Extensor digitorum longus weight0.20.61.50.50.10.80.5-0.5-1.20.81.2
Bone: elastic displacement0.20.30.8-0.30.20.4-0.5-0.10.3-0.8-0.9
Bone: elastic work0.50.72.0-0.1-0.3-0.3-0.50.51.3-1.0-1.4
Bone: endosteal estimation0.91.94.71.3-0.9-0.91.70.60.12.02.2
Bone: endosteal perimeter1.83.66.22.2-1.8-1.22.31.40.72.52.4
Epididymis fat weight1.33.06.5-1.72.01.8-1.3-2.2-2.50.21.0
Delta time in closed arm before/after self-admin0.80.82.10.9-0.20.61.3-0.5-0.40.81.4
Delta time in open arm before/after self-admin0.80.81.50.8-0.9-0.90.80.90.31.21.0
Diff in mean of infusions in LGA sessions2.93.26.2-1.61.72.5-1.9-1.7-1.8-1.7-1.3
Delay discount exponential model param0.90.91.7-1.11.11.0-0.9-1.0-1.3-0.6-0.3
Extinction: sum of active levers before priming0.20.20.60.5-0.3-0.10.60.1-0.20.70.8
Active lever presses in extinction session 60.60.51.80.4-0.7-1.40.50.90.90.2-0.3
Bone: final force0.20.30.60.7-0.7-0.50.60.80.30.30.2
Bone: final moment0.20.30.60.7-0.7-0.50.60.80.30.40.3
Food consumed during 24 hour testing period1.31.63.01.2-1.5-1.70.61.51.70.70.1
Glucose0.30.51.01.0-1.0-0.40.50.90.60.60.4
Heart weight1.11.62.61.3-1.2-1.41.61.01.01.31.1
Delay discount hyperbolic model param1.01.11.6-1.21.21.1-1.0-1.1-1.3-0.8-0.6
Intermittent access intake day 1-15 change2.22.24.71.5-1.7-1.61.11.82.20.90.3
Intermittent access intake escalation2.72.75.11.7-1.8-1.81.31.92.31.10.5
Intermittent access intake escalation 20.50.51.00.5-0.7-1.00.40.80.80.70.4
Intermitt. access day 1 inactive lever presses0.60.61.5-1.10.80.3-1.2-0.5-0.4-0.6-0.7
Intermitt. access day 15 inactive lever presses0.10.10.20.0-0.10.2-0.20.10.5-0.2-0.3
Intermitt. access escalation Index0.50.40.8-0.50.40.9-0.9-0.4-0.1-0.7-0.8
Intermittent access day 1 total infusions1.11.21.51.2-1.2-1.21.11.10.81.20.9
Intermittent access day 15 total infusions3.74.27.12.1-2.3-2.41.52.42.71.60.7
Intermittent access terminal intake (last 3 days)2.02.23.81.4-1.6-2.00.91.71.91.30.7
Intermittent access total infusions1.41.62.91.1-1.3-1.70.81.51.41.20.6
Intermittent access day 1 locomotion0.40.41.10.2-0.7-0.8-0.21.00.80.2-0.4
Intermittent access day 15 total locomotion1.51.62.81.2-1.4-1.71.01.41.41.20.7
Intermittent access total locomotion0.60.71.30.7-0.9-1.10.41.10.80.90.5
Intermittent access standard deviation0.10.10.2-0.1-0.1-0.4-0.20.20.40.30.1
Left kidney weight0.41.14.30.30.30.00.8-0.8-0.71.52.1
Right kidney weight0.20.62.0-0.20.70.20.3-1.1-0.70.81.4
Cocaine induced anxiety1.21.42.2-1.21.31.5-1.1-1.2-0.9-1.3-0.8
Post-drug Anxiety0.10.10.2-0.20.30.20.0-0.50.0-0.30.1
Baseline Anxiety2.83.04.91.9-1.8-2.21.91.51.61.61.2
Tail length1.13.48.8-0.51.51.30.5-2.3-2.51.63.0
Length with tail0.93.26.4-0.91.82.1-0.5-2.5-2.50.71.9
Length without tail0.10.30.8-0.10.20.9-0.7-0.30.0-0.7-0.7
Times rat made contact with spout1.01.11.5-1.11.21.2-1.2-1.2-1.2-0.6-0.2
Lifetime Intake1.82.03.71.2-1.5-1.91.11.61.61.30.8
Liver weight, left0.71.12.7-0.71.01.6-0.9-1.1-1.6-0.20.3
Liver weight, right3.96.610.1-2.73.02.9-2.6-3.0-3.2-1.2-0.1
Locomotor activity0.30.41.6-0.60.90.3-0.2-1.3-0.4-0.40.2
Locomotor testing distance0.50.93.20.50.1-0.31.4-0.6-0.41.11.8
Locomotor testing rearing1.11.84.2-0.51.21.50.4-1.6-2.10.71.7
Locomotion in novel chamber0.70.92.50.8-1.2-0.90.21.61.30.2-0.3
Locomotion in novel chamber post-restriction3.03.66.82.1-2.5-2.01.32.62.21.00.1
Fecal boli incidents, locomotor time 13.43.77.01.7-2.0-2.62.22.21.71.60.9
Change in fecal boli incidents, locomotor task2.12.02.9-1.31.41.7-1.6-1.5-0.7-1.7-1.2
Time >=10cm from walls, locomotor time 10.80.81.71.0-1.2-0.80.71.31.10.4-0.1
Bouts of movement, locomotor time 10.40.41.21.1-0.8-0.10.80.50.30.50.5
Total resting periods, locomotor time 10.30.41.01.0-0.9-0.20.50.70.60.20.0
Rest time, locomotor task time 10.40.50.90.9-0.9-0.50.60.90.90.1-0.2
Distance moved, locomotor task time 10.40.41.7-0.00.3-0.00.3-0.4-0.50.91.3
Vertical activity count, locomotor time 10.20.20.80.10.1-0.30.2-0.3-0.30.70.9
Time >=10cm from walls, locomotor time 20.70.71.40.9-0.9-0.70.90.80.11.20.9
Bouts of movement, locomotor time 20.10.10.40.2-0.1-0.50.1-0.10.60.30.4
Total resting periods, locomotor time 20.10.10.40.1-0.0-0.60.1-0.10.70.20.3
Rest time, locomotor task time 21.21.32.1-1.31.11.1-1.1-0.8-0.8-1.5-1.4
Distance moved, locomotor task time 21.82.14.61.3-1.2-1.31.41.00.52.12.1
Vertical activity count, locomotor time 21.21.33.50.9-0.6-1.21.00.40.01.71.9
Light reinforcement 11.62.94.4-1.91.91.8-1.5-1.8-2.1-1.3-0.8
Light reinforcement 20.20.30.5-0.70.50.5-0.6-0.3-0.7-0.6-0.6
Bone: marrow area0.71.54.01.2-0.8-0.71.50.50.01.82.0
Bone: maximum diameter1.32.44.21.8-1.4-0.81.91.10.22.02.0
Bone: maximum force0.50.81.61.1-1.2-0.90.91.30.80.50.2
Bone: maximum moment0.50.91.61.1-1.2-0.90.91.30.80.60.3
Mean time between licks in bursts1.82.56.41.1-0.8-1.61.50.50.82.42.5
Mean num. licks in bursts1.82.22.51.6-1.6-1.61.51.51.31.51.2
Cd content in liver0.40.51.7-0.60.70.7-0.4-0.8-1.3-0.20.1
Co content in liver1.21.43.11.2-0.9-0.71.50.70.31.71.7
Cu content in liver0.60.72.70.5-0.0-0.31.0-0.4-0.01.21.6
Fe content in liver0.60.81.30.7-0.8-1.10.80.90.91.00.7
K content in liver0.70.71.2-1.11.10.2-1.1-1.0-0.2-0.8-0.5
Mg content in liver0.10.10.50.1-0.1-0.70.1-0.00.30.20.2
Mn content in liver0.80.92.6-0.90.50.2-1.2-0.10.2-1.3-1.6
Na content in liver0.50.61.2-0.70.2-0.9-0.80.20.8-0.7-1.1
Rb content in liver0.60.71.51.1-0.7-0.41.00.20.41.01.2
Se content in liver1.82.23.6-1.91.40.6-1.8-1.0-0.6-1.8-1.8
Sr content in liver0.70.61.00.9-1.0-0.80.71.00.80.50.2
Zn content in liver1.61.72.91.3-1.0-1.41.70.70.71.61.7
Bone: minimum diameter0.71.24.10.50.00.21.2-0.3-1.31.52.0
Time in familiar zone, hab. session 10.00.00.10.1-0.2-0.00.00.3-0.30.20.0
Time in novel zone, hab. session 10.30.30.8-0.40.70.6-0.1-0.9-0.3-0.20.3
Total zone transitions, hab. session 10.40.61.7-0.40.30.9-0.6-0.20.3-1.3-1.2
Total locomotion distance, hab. session 15.98.411.9-3.33.53.2-2.6-3.3-3.4-1.8-0.8
Locomotion velocity, hab. session 15.27.310.5-3.23.22.9-2.5-3.0-3.2-1.8-0.8
Time in familiar zone, hab. session 20.50.50.90.9-0.7-0.40.70.40.31.01.0
Time in novel zone, hab. session 20.10.10.10.0-0.2-0.40.30.30.00.20.0
Total zone transitions, hab. session 20.10.20.40.2-0.10.60.10.00.3-0.7-0.6
Total locomotion distance, hab. session 23.64.77.6-2.32.72.6-1.6-2.7-2.8-1.1-0.1
Locomotion velocity, hab. session 24.05.48.8-2.42.82.9-1.7-2.9-3.0-1.2-0.1
Novel to familiar place preference ratio0.10.10.4-0.30.30.6-0.3-0.2-0.2-0.4-0.3
Novelty place preference0.00.00.2-0.00.10.4-0.1-0.1-0.1-0.1-0.1
Time in novel zone, NPP test0.00.00.10.3-0.20.20.10.20.10.10.1
Total zone transitions, NPP test0.30.41.00.7-0.8-0.40.60.81.0-0.1-0.3
Total locomotion distance, NPP test2.23.06.2-2.12.21.8-1.2-2.0-2.5-0.7-0.0
Locomotion velocity, NPP test3.04.28.0-2.52.52.0-1.6-2.3-2.8-1.0-0.3
Intraocular pressure4.05.69.12.9-3.0-2.02.32.92.31.80.9
Delta distance traveled before/after self-admin0.50.51.1-0.60.60.4-0.8-0.60.5-1.0-0.9
Delta ambulatory time before/after self-admin0.40.51.3-0.30.20.4-0.6-0.30.7-1.1-1.2
Parametrial fat weight1.83.57.5-1.62.12.3-1.3-2.2-2.7-1.1-0.3
Pavlov. Cond. lever latency1.01.32.2-1.11.11.5-1.1-1.0-1.1-1.2-1.0
Pavlov. Cond. magazine entry latency1.21.52.81.2-0.9-1.21.60.70.41.61.7
Pavlov. Cond. change in total contacts1.61.73.41.1-1.2-1.91.31.30.61.61.2
Pavlov. Cond. index score1.82.33.71.4-1.2-1.71.80.90.91.91.9
Pavlov. Cond. latency score1.62.03.21.3-1.1-1.61.61.00.91.81.7
Pavlov. Cond. lever contacts1.11.32.01.0-0.9-1.41.20.80.91.41.3
Pavlov. Cond. magazine entry number1.72.13.3-1.61.21.5-1.8-0.9-0.7-1.8-1.8
Pavlov. Cond. intertrial magazine entries0.91.11.6-1.21.11.0-1.1-1.0-1.2-0.9-0.7
Pavlov. Cond. lever-magazine prob. diff.1.62.03.01.3-1.1-1.71.61.01.01.71.7
Pavlov. Cond. response bias0.70.81.60.8-0.6-1.21.10.40.41.21.3
Pavlov. Cond. lever latency12.617.025.5-4.94.33.9-5.0-3.5-3.2-4.1-3.6
Pavlov. Cond. magazine entry latency5.56.39.53.1-2.9-2.43.02.62.22.01.5
Pavlov. Cond. change in total contacts7.410.215.83.8-3.3-2.94.02.72.43.32.9
Pavlov. Cond. index score10.914.120.74.5-4.0-3.64.53.43.03.63.1
Pavlov. Cond. latency score10.212.718.94.3-3.8-3.44.43.32.93.42.8
Pavlov. Cond. lever contacts11.215.222.94.7-4.0-3.64.83.23.13.93.5
Pavlov. Cond. magazine entry number11.814.520.6-4.54.33.7-4.4-3.9-3.0-3.5-2.7
Pavlov. Cond. intertrial magazine entries1.72.24.5-1.62.01.3-0.9-2.1-1.9-0.20.7
Pavlov. Cond. lever-magazine prob. diff.10.313.119.54.3-3.8-3.44.43.22.83.63.1
Pavlov. Cond. response bias13.218.026.05.0-4.4-4.15.13.73.44.23.6
Time in closed arm before self-admin0.60.72.70.2-0.6-1.0-0.20.81.6-0.4-0.9
Time in closed arm after self-admin0.91.03.00.8-1.1-0.80.51.11.7-0.3-0.8
Time in open arm before self-admin1.21.31.9-1.11.31.4-0.7-1.3-1.4-0.9-0.4
Time in open arm after self-admin0.60.62.2-0.40.70.8-0.2-0.8-1.50.30.8
Bone: periosteal estimation1.42.96.01.7-1.3-1.12.11.0-0.12.42.5
Bone: periosteal perimeter1.01.63.51.6-1.1-0.41.60.60.11.71.9
Bone: post-yield work0.00.10.10.1-0.2-0.1-0.10.30.3-0.2-0.3
Progressive ratio test 1 active lever presses0.10.10.3-0.30.1-0.1-0.30.10.4-0.3-0.6
Progressive ratio test 1 breakpoint0.10.10.4-0.40.2-0.1-0.50.10.2-0.4-0.6
Progressive ratio test 1 inactive lever presses0.10.10.30.1-0.2-0.40.10.20.50.30.1
Progressive ratio test 2 active lever presses2.02.23.81.4-1.5-1.61.31.41.01.91.5
Progressive ratio test 2 breakpoint1.31.52.91.2-1.2-1.31.01.20.81.71.3
Progressive ratio test 2 inactive lever presses0.91.11.51.0-1.0-1.20.91.01.11.20.9
Incentive Sensitization - Responses2.32.44.51.6-1.5-1.51.31.30.92.11.7
Incentive Sensitization - Breakpoint2.22.24.11.5-1.5-1.61.21.30.92.01.6
Sum of active levers in priming session hrs 5-60.30.30.6-0.60.70.3-0.6-0.7-0.8-0.4-0.3
Progressive ratio1.01.22.01.3-1.4-0.91.31.40.90.60.3
Food seeking constrained by brief footshock0.50.72.30.40.10.01.2-0.5-0.50.91.5
Seeking ratio, punishment vs. effort0.91.12.4-1.11.40.6-0.7-1.5-1.20.20.8
Retroperitoneal fat weight4.113.629.6-3.14.14.7-2.6-4.7-5.4-0.71.2
Reaction time number correct0.50.71.8-0.80.60.7-0.7-0.5-0.1-1.3-1.3
Reaction time mean minus median0.20.31.00.5-0.10.00.7-0.2-0.20.61.0
Reaction time mean minus median AUC0.10.10.40.5-0.2-0.10.60.00.00.40.6
Reaction time num false alarms0.81.13.1-0.91.01.4-0.7-1.0-1.8-0.6-0.2
Reaction time num false alarms AUC0.20.20.7-0.40.40.6-0.4-0.3-0.8-0.3-0.2
Reaction time trials correct on left0.50.71.8-0.80.60.7-0.7-0.5-0.1-1.3-1.3
Reaction time trials on left0.50.71.8-0.70.60.7-0.6-0.5-0.0-1.3-1.3
Reaction time mean0.20.30.6-0.60.80.4-0.3-0.8-0.6-0.3-0.1
Reaction time mean AUC0.20.20.4-0.60.60.3-0.4-0.6-0.5-0.4-0.2
Median of all reaction times0.20.30.6-0.80.70.1-0.5-0.6-0.4-0.5-0.5
Reaction time omissions0.10.20.60.4-0.1-0.10.6-0.20.10.50.8
Reaction time false alarm rate0.10.10.7-0.10.10.2-0.10.0-0.80.30.3
Reaction time premature initiation rate0.81.13.1-0.30.90.40.3-1.3-1.31.01.7
Reaction time premature initiations0.40.61.6-0.51.00.40.1-1.3-0.90.41.0
Std. dev. reaction times0.30.41.50.20.30.10.6-0.6-0.60.71.2
Reaction time trials completed0.50.71.8-0.70.60.7-0.6-0.5-0.0-1.3-1.3
Reaction time trials AUC0.40.61.5-0.80.70.8-0.6-0.6-0.2-1.2-1.1
Run reversals in cocaine runway, females1.31.33.30.10.60.90.6-1.1-1.71.11.8
Run reversals in cocaine runway, males1.71.63.31.6-1.6-1.01.01.41.80.70.2
Latency to leave start box in cocaine runway1.31.42.7-1.71.50.5-1.2-1.2-1.1-1.1-0.9
Latency to leave start box in cocaine runway, F0.80.91.9-1.31.20.3-0.6-1.0-1.4-0.3-0.1
Latency to leave start box in cocaine runway, M1.00.92.1-1.10.70.2-1.3-0.40.3-1.3-1.5
Std. dev. time between licks in bursts0.60.81.5-0.61.00.5-0.1-1.2-1.20.51.2
Total sessions with >9 infusions1.21.43.50.8-1.1-1.90.91.31.50.80.3
Short access day 1 total inactive lever presses0.30.40.50.6-0.7-0.60.50.70.70.50.3
Short access day 10 total inactive lever presses1.41.52.4-1.21.21.5-1.6-1.2-0.9-1.2-0.9
Short access day 1 total infusions1.51.63.81.0-1.1-1.91.21.21.21.41.0
Short access day 10 total infusions1.41.62.91.1-1.1-1.71.31.30.81.41.1
Short access total infusions0.80.92.20.6-0.8-1.50.91.00.91.00.7
Short access day 1 locomotion2.72.96.21.5-1.9-2.51.32.02.30.90.2
Short access day 10 total locomotion0.10.20.60.2-0.3-0.80.10.30.30.40.3
Short access total locomotion0.20.21.0-0.40.1-1.0-0.40.30.3-0.2-0.4
One hour access (0.3 mA shock)2.22.63.91.5-1.5-1.91.61.41.32.01.7
Compulsive drug intake0.00.00.1-0.30.2-0.3-0.2-0.0-0.2-0.1-0.2
One hour access (shock baseline)1.41.62.21.3-1.3-1.51.11.21.31.31.1
Social response proportion2.22.43.8-1.91.91.2-1.7-1.7-1.4-1.3-0.9
Social responses1.62.04.0-1.41.81.5-1.1-2.0-1.9-0.70.1
Social time1.72.23.6-1.91.70.9-1.6-1.5-1.2-1.6-1.3
Soleus weight0.41.32.5-0.61.21.4-0.3-1.6-1.60.31.2
Bone: stiffness0.00.10.20.2-0.20.2-0.00.3-0.4-0.2-0.2
Tibialis anterior weight0.20.51.6-0.20.61.2-0.2-0.8-1.30.00.4
Time to tail flick, vehicle, before self-admin0.40.41.0-0.70.80.6-0.6-1.0-0.4-0.5-0.3
Time to tail flick, vehicle, after self-admin1.81.93.11.6-1.5-1.51.61.31.80.90.5
Time to tail flick, test, before self-admin0.70.61.01.0-0.80.51.00.7-0.60.90.8
Time to tail flick, test, after self-admin1.21.22.91.1-0.8-0.71.70.5-0.21.41.5
Delta time to tail flick, vehicle, before/after SA3.03.04.91.8-2.0-1.91.62.02.21.00.3
Delta time to tail flick, test, before/after SA0.10.10.2-0.40.4-0.4-0.2-0.40.1-0.4-0.3
Tibia length0.61.62.61.3-1.5-1.41.31.61.40.90.4
Ambulatory time before self-admin0.00.00.10.2-0.3-0.1-0.10.40.1-0.1-0.3
Ambulatory time after self-admin0.80.92.5-0.60.40.6-1.1-0.20.4-1.5-1.6
Bone: tissue strength1.71.64.7-1.00.50.5-1.8-0.10.6-1.8-2.2
Total heroin consumption0.00.00.10.3-0.3-0.00.10.2-0.0-0.0-0.1
Bone: trabecular number0.20.31.2-0.30.10.1-0.70.20.4-0.9-1.1
Bone: trabecular spacing0.40.50.90.5-0.6-0.90.90.60.60.70.6
Bone: trabecular thickness0.20.30.60.30.10.80.1-0.5-0.80.10.6
Bone: trabecular tissue density2.53.56.7-1.62.12.6-1.4-2.4-2.4-1.1-0.2
Water consumed over 24 hours1.21.42.3-1.31.21.1-1.5-1.1-0.8-1.4-1.2
Number of responses in last shaping day0.40.40.9-0.70.7-0.00.1-0.7-1.00.60.8