Hub : Genes

Ism1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 LHb gene expression Ism1 0.51 0.14 9.3e-11 0.42 0.45 0.43 0.44 4.7e-11 4.1e-12 2.2e-11 9.3e-12
2 Adipose gene expression Ism1 0.06 0.03 9.2e-06 0.02 0.04 0.03 0.04 1.3e-03 8.5e-05 5.8e-04 7.3e-05
3 PL gene expression Ism1 0.02 0.02 3.9e-03 0.02 0.01 0 0.01 5.5e-03 3.0e-02 2.1e-01 4.9e-02
4 Brain gene expression Ism1 0.11 0.06 5.5e-11 0.11 0.12 0.11 0.11 2.1e-10 3.7e-11 1.2e-10 1.4e-10
5 Liver gene expression Ism1 0.05 0.03 8.8e-04 0.01 0.01 0 0.01 2.1e-02 2.0e-02 1.2e-01 3.7e-02
6 OFC gene expression Ism1 0.27 0.13 1.2e-04 0.07 0.14 0.11 0.09 9.5e-03 2.8e-04 1.7e-03 3.0e-03
7 pVTA gene expression Ism1 0.08 0.05 1.4e-03 0.03 0.05 0.03 0.03 1.7e-02 2.4e-03 1.9e-02 1.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bone: apparent density1.11.82.60.10.71.5-1.51.6-1.6-1.6
Area under the delay curve0.50.51.01.00.9-0.40.6-0.70.60.5
BMI with tail4.213.717.2-3.3-2.34.2-4.13.9-3.7-4.0
BMI without tail3.47.09.0-2.4-1.63.0-3.02.7-2.5-2.9
Body weight6.627.531.8-5.3-3.95.5-5.65.5-5.3-5.4
Weight adjusted by age0.60.60.9-0.9-0.70.7-1.00.7-0.6-0.9
Bone surface0.81.44.41.52.11.0-0.70.6-0.6-1.0
Bone volume0.71.21.70.61.21.2-1.11.1-1.1-1.3
Breakpoint value in progressive ratio session1.51.62.6-1.5-1.61.2-1.41.0-0.7-1.3
Number of licking bursts0.50.51.6-0.9-1.30.2-0.10.7-0.90.1
Context. condit. distance diff. score0.20.20.3-0.3-0.20.5-0.50.5-0.4-0.5
Locomotion velocity, session 10.50.60.90.90.7-0.90.5-0.80.90.5
Locomotion distance, session 12.93.78.22.92.8-1.31.4-1.61.71.1
Locomotion velocity, session 21.72.02.41.61.4-1.41.3-1.41.51.2
Locomotion distance, session 23.44.77.32.72.4-1.82.0-2.22.21.8
Locomotion velocity, session 30.50.61.31.11.1-0.50.8-0.3-0.00.7
Locomotion distance, session 30.00.00.10.00.20.20.00.2-0.30.0
Stereotopy head waving bouts, day 30.50.61.20.10.30.9-0.71.0-1.1-0.8
Stereotopy head waving duration, day 30.20.20.40.10.10.6-0.50.6-0.6-0.5
Locomotion velocity, session 70.30.30.90.1-0.1-0.70.8-0.40.10.9
Locomotion distance, session 70.20.20.6-0.3-0.20.5-0.30.6-0.8-0.2
Stereotopy head waving bouts, day 70.00.00.1-0.1-0.10.0-0.30.3-0.3-0.3
Stereotopy head waving duration, day 70.10.20.50.70.70.1-0.20.2-0.2-0.3
Locomotion velocity, session 80.70.80.90.90.8-1.00.9-1.01.00.8
Locomotion distance, session 80.71.12.01.41.4-0.80.9-0.90.90.7
Degree of sensitization distance0.10.10.30.40.50.3-0.20.2-0.3-0.2
Degree of sensitization stereotypy0.10.10.2-0.3-0.30.1-0.40.4-0.4-0.3
Conditioned locomotion1.61.82.4-1.4-1.11.5-1.41.4-1.3-1.4
Cocaine response after cond. corrected0.10.20.3-0.2-0.5-0.40.5-0.20.10.6
Cocaine response after cond. not corrected0.20.20.30.20.0-0.50.6-0.40.30.6
Cocaine response before conditioning0.40.52.01.21.4-0.20.2-0.40.40.1
Saline control response0.00.00.1-0.0-0.00.2-0.2-0.10.2-0.2
Bone: connectivity density1.42.23.61.11.91.7-1.31.3-1.3-1.6
Bone: cortical apparent density1.52.06.5-2.1-2.50.4-0.70.9-1.0-0.3
Bone: cortical area5.38.015.2-3.9-3.62.3-2.62.4-2.3-2.2
Bone: cortical porosity1.61.72.8-0.40.21.6-1.61.5-1.4-1.7
Bone: cortical porosity2.32.53.4-1.2-0.61.8-1.81.8-1.7-1.8
Bone: cortical thickness11.418.734.1-5.8-5.43.5-4.03.8-3.6-3.5
Bone: cortical thickness5.56.39.4-3.1-3.01.9-2.02.6-2.9-1.6
Bone: cortical tissue density1.21.65.7-2.0-2.40.2-0.50.8-0.9-0.2
Condit. Reinf. active minus inactive responses1.01.11.8-0.20.01.4-1.11.2-1.3-1.2
Condit. Reinf. active-inactive response ratio0.80.81.5-0.5-0.41.1-0.81.1-1.2-0.9
Condit. Reinf. active responses0.00.00.00.20.10.00.00.1-0.20.0
Condit. Reinf. inactive responses1.01.21.90.80.6-1.41.1-1.21.21.2
Incentive salience index mean0.30.41.21.11.1-0.10.3-0.30.30.2
Condit. Reinf. lever presses2.02.73.31.81.6-1.51.6-1.81.81.5
Condit. Reinf. active minus inactive responses0.20.30.30.50.5-0.60.5-0.50.50.5
Condit. Reinf. active-inactive response ratio0.20.30.30.40.3-0.60.6-0.60.50.5
Condit. Reinf. active responses0.20.20.30.40.5-0.40.4-0.50.50.4
Condit. Reinf. inactive responses0.10.10.20.20.3-0.20.3-0.40.40.3
Condit. Reinf. lever presses1.72.25.32.32.3-0.71.1-1.21.20.8
Condit. Reinf. lever reinforcers received0.40.60.80.80.8-0.70.7-0.80.90.7
Conditioned reinforcement - actives1.61.62.31.41.5-1.01.1-1.31.41.0
Conditioned reinforcement - inactives1.11.32.01.11.2-0.81.1-1.31.40.9
Conditioned locomotion1.82.12.51.51.3-1.51.6-1.51.41.5
Patch foraging indifference point 0 sec1.62.73.51.81.9-1.31.7-1.61.51.5
Patch foraging indifference point AUC6.87.811.61.1-0.3-3.43.3-3.23.13.4
Delay disc. indifference point, 0s delay0.00.00.00.20.1-0.2-0.10.00.1-0.1
Delay disc. indifference point, 16s delay1.61.61.91.41.2-1.11.3-1.31.31.2
Delay disc. indifference point, 2s delay1.51.64.02.01.9-0.71.0-1.00.90.8
Delay disc. indifference point, 24s delay0.20.20.40.50.4-0.20.4-0.50.60.3
Delay disc. indifference point, 4s delay0.10.10.30.50.3-0.00.2-0.0-0.10.2
Delay disc. indifference point, 8s delay0.10.10.50.40.70.1-0.10.0-0.0-0.2
Indifference point function ln k4.66.310.4-0.90.33.2-2.82.9-2.9-3.0
Indifference point function log k4.66.310.4-0.90.33.2-2.82.9-2.9-3.0
Patch foraging total patch changes 0 sec2.13.54.11.91.8-1.62.0-1.91.81.9
Patch foraging total patch changes 12 sec2.83.75.31.41.0-2.02.1-2.22.32.0
Patch foraging total patch changes 18 sec9.312.016.22.41.0-4.04.0-3.93.84.0
Patch foraging total patch changes 24 sec7.38.912.52.11.0-3.53.3-3.33.23.3
Patch foraging total patch changes 6 sec4.16.19.01.30.4-2.93.0-2.82.73.0
Patch foraging time to switch 0 sec2.53.96.2-1.1-0.12.2-2.52.2-2.0-2.5
Patch foraging water rate 0 sec3.35.48.81.30.1-2.72.9-2.52.33.0
Patch foraging water rate 12 sec0.91.32.50.5-0.2-1.21.6-1.31.11.5
Patch foraging water rate 18 sec0.60.81.5-0.6-1.2-0.91.0-0.60.51.1
Patch foraging water rate 24 sec1.82.54.4-0.7-1.7-1.71.9-1.41.12.1
Patch foraging water rate 6 sec0.81.24.6-1.7-2.1-0.1-0.00.4-0.60.3
Seeking ratio, delayed vs. immediate footshock1.11.32.2-0.30.11.5-1.31.3-1.2-1.4
Distance traveled before self-admin0.40.40.80.4-0.2-0.90.6-0.70.80.6
Distance traveled after self-admin1.41.66.9-1.9-2.6-0.20.1-0.20.40.3
Extensor digitorum longus weight0.00.10.20.10.30.5-0.20.2-0.1-0.3
Bone: elastic displacement0.70.82.5-1.5-1.60.3-0.40.5-0.6-0.2
Bone: elastic work3.84.86.9-2.6-2.22.0-2.32.1-2.0-2.1
Bone: endosteal estimation1.32.811.02.83.30.10.4-0.50.60.0
Bone: endosteal perimeter1.02.16.82.32.6-0.20.7-0.91.00.4
Epididymis fat weight6.615.519.7-3.4-2.24.3-4.44.3-4.1-4.3
Delta time in closed arm before/after self-admin0.10.10.1-0.1-0.1-0.30.30.1-0.40.4
Delta time in open arm before/after self-admin1.51.52.1-1.5-1.31.1-1.21.2-1.1-1.1
Diff in mean of infusions in LGA sessions0.00.00.00.0-0.2-0.00.2-0.0-0.10.2
Delay discount exponential model param0.40.40.8-0.9-0.80.4-0.60.6-0.6-0.5
Extinction: sum of active levers before priming0.20.21.0-0.7-1.0-0.4-0.0-0.20.30.1
Active lever presses in extinction session 62.12.03.0-1.2-0.91.6-1.71.4-1.1-1.7
Bone: final force4.06.49.8-3.1-2.82.2-2.42.4-2.4-2.1
Bone: final moment3.65.88.0-2.8-2.42.2-2.42.4-2.3-2.2
Food consumed during 24 hour testing period2.53.05.61.42.42.2-1.51.3-1.1-1.9
Glucose0.91.42.0-0.7-0.31.4-1.31.4-1.4-1.3
Heart weight1.92.73.4-1.8-1.41.8-1.71.6-1.5-1.7
Delay discount hyperbolic model param0.50.51.1-1.0-0.90.4-0.70.6-0.5-0.6
Intermittent access intake day 1-15 change1.51.55.51.32.31.1-0.70.4-0.2-1.1
Intermittent access intake escalation1.91.87.61.72.81.0-0.60.2-0.0-1.0
Intermittent access intake escalation 22.02.07.31.72.71.1-0.90.3-0.1-1.3
Intermitt. access day 1 inactive lever presses0.40.41.20.71.1-0.20.7-0.50.40.6
Intermitt. access day 15 inactive lever presses1.11.22.0-0.10.41.4-1.11.3-1.3-1.2
Intermitt. access escalation Index1.21.11.5-0.8-0.31.2-1.11.2-1.2-1.1
Intermittent access day 1 total infusions1.31.52.5-1.1-0.61.5-1.11.5-1.6-1.1
Intermittent access day 15 total infusions1.51.73.30.31.31.8-1.21.3-1.2-1.5
Intermittent access terminal intake (last 3 days)1.41.52.80.11.11.7-1.21.3-1.3-1.4
Intermittent access total infusions1.21.42.8-0.20.61.7-1.11.3-1.3-1.3
Intermittent access day 1 locomotion0.40.41.1-0.00.30.5-0.50.9-1.0-0.5
Intermittent access day 15 total locomotion0.40.52.11.01.40.3-0.00.1-0.1-0.2
Intermittent access total locomotion0.20.31.20.71.10.20.00.3-0.4-0.1
Intermittent access standard deviation2.02.29.42.23.10.50.1-0.40.6-0.4
Left kidney weight0.72.13.1-1.5-1.11.5-1.31.6-1.7-1.2
Right kidney weight0.82.23.3-1.8-1.61.4-1.21.6-1.7-1.0
Cocaine induced anxiety1.21.43.01.71.5-0.91.0-1.01.00.8
Post-drug Anxiety0.20.20.40.50.7-0.40.3-0.50.60.3
Baseline Anxiety2.32.53.8-2.0-1.61.3-1.51.6-1.6-1.3
Tail length1.13.34.4-2.1-1.61.7-1.91.9-1.9-1.7
Length with tail2.48.910.6-3.3-2.62.9-3.13.1-3.1-2.9
Length without tail1.22.73.3-1.5-1.21.7-1.81.8-1.7-1.7
Times rat made contact with spout0.20.20.80.80.90.20.1-0.10.1-0.0
Lifetime Intake0.70.81.8-0.20.41.4-0.81.0-1.1-1.0
Liver weight, left0.71.11.7-1.0-0.41.3-1.21.0-0.8-1.2
Liver weight, right1.62.76.8-2.6-2.41.4-1.21.0-0.9-1.0
Locomotor activity0.81.34.11.62.0-0.40.6-0.91.00.4
Locomotor testing distance1.62.66.12.22.5-1.11.2-1.41.50.9
Locomotor testing rearing2.84.35.92.42.4-1.81.9-2.12.11.7
Locomotion in novel chamber1.72.16.1-2.3-2.50.5-0.90.9-0.9-0.6
Locomotion in novel chamber post-restriction0.10.10.5-0.2-0.7-0.4-0.0-0.20.30.0
Fecal boli incidents, locomotor time 10.00.00.10.00.1-0.10.2-0.20.20.2
Change in fecal boli incidents, locomotor task0.90.91.4-0.8-0.80.9-0.91.1-1.2-0.8
Time >=10cm from walls, locomotor time 10.10.10.1-0.00.30.3-0.20.00.1-0.3
Bouts of movement, locomotor time 10.80.81.20.1-0.2-1.01.1-1.11.11.1
Total resting periods, locomotor time 10.80.91.30.2-0.1-1.01.1-1.11.11.1
Rest time, locomotor task time 10.60.62.51.11.60.6-0.20.3-0.4-0.4
Distance moved, locomotor task time 11.11.23.3-1.1-1.8-1.10.8-0.80.71.0
Vertical activity count, locomotor time 10.10.10.1-0.10.00.2-0.30.3-0.3-0.3
Time >=10cm from walls, locomotor time 21.92.03.4-0.50.41.7-1.81.5-1.3-1.9
Bouts of movement, locomotor time 20.10.20.7-0.5-0.8-0.10.20.0-0.10.2
Total resting periods, locomotor time 20.10.20.7-0.5-0.8-0.10.20.0-0.10.2
Rest time, locomotor task time 20.10.10.3-0.4-0.3-0.40.4-0.1-0.10.5
Distance moved, locomotor task time 20.60.71.31.21.0-0.60.5-0.91.00.4
Vertical activity count, locomotor time 20.80.92.71.51.6-0.10.2-0.70.9-0.1
Light reinforcement 10.91.64.02.01.9-0.90.8-0.80.80.6
Light reinforcement 20.20.20.90.60.90.1-0.30.2-0.1-0.4
Bone: marrow area1.32.810.82.83.30.00.5-0.60.60.1
Bone: maximum diameter0.30.50.9-0.9-0.80.8-0.70.6-0.6-0.6
Bone: maximum force3.35.77.5-2.7-2.32.2-2.52.4-2.3-2.3
Bone: maximum moment2.95.16.1-2.3-1.82.3-2.52.3-2.2-2.3
Mean time between licks in bursts1.72.36.8-2.5-2.60.7-1.00.9-0.8-0.7
Mean num. licks in bursts0.50.62.51.11.60.3-0.2-0.30.6-0.5
Cd content in liver3.13.45.2-1.0-0.32.2-2.22.0-1.9-2.3
Co content in liver0.40.51.10.3-0.2-0.60.6-0.91.10.6
Cu content in liver0.20.20.30.60.5-0.40.5-0.50.50.4
Fe content in liver0.30.30.90.91.00.00.1-0.50.6-0.0
K content in liver3.13.14.71.30.7-2.11.8-2.12.21.7
Mg content in liver0.20.20.40.2-0.1-0.70.5-0.60.60.5
Mn content in liver3.64.16.80.4-0.4-2.62.3-2.32.22.5
Na content in liver2.52.64.02.02.0-1.31.3-1.61.81.1
Rb content in liver2.43.03.9-1.9-2.01.4-1.51.8-1.9-1.3
Se content in liver1.01.31.7-1.3-1.01.2-1.01.2-1.3-0.8
Sr content in liver2.01.83.71.91.9-0.81.0-1.21.30.8
Zn content in liver1.41.62.8-0.6-0.11.6-1.61.2-1.0-1.7
Bone: minimum diameter0.71.32.0-0.8-0.31.4-1.41.2-1.1-1.4
Time in familiar zone, hab. session 10.70.62.51.31.60.00.1-0.10.1-0.1
Time in novel zone, hab. session 10.30.30.6-0.3-0.8-0.70.6-0.40.30.7
Total zone transitions, hab. session 10.10.10.20.50.4-0.40.4-0.30.20.4
Total locomotion distance, hab. session 10.91.21.80.90.6-1.31.3-1.11.01.3
Locomotion velocity, hab. session 10.50.71.10.30.0-1.01.0-0.90.91.0
Time in familiar zone, hab. session 20.70.72.81.41.70.00.1-0.10.1-0.1
Time in novel zone, hab. session 20.40.41.5-0.9-1.20.1-0.10.2-0.2-0.0
Total zone transitions, hab. session 20.40.51.61.11.3-0.10.2-0.50.60.0
Total locomotion distance, hab. session 22.83.75.72.42.0-1.61.8-2.02.11.5
Locomotion velocity, hab. session 22.93.85.02.11.6-1.81.9-2.22.21.8
Novel to familiar place preference ratio0.10.10.2-0.3-0.4-0.1-0.10.2-0.3-0.1
Novelty place preference0.20.20.7-0.7-0.90.0-0.30.4-0.4-0.2
Time in novel zone, NPP test0.30.30.7-0.8-0.80.2-0.40.5-0.5-0.4
Total zone transitions, NPP test1.01.42.41.31.1-1.00.9-1.41.50.8
Total locomotion distance, NPP test3.75.06.62.62.1-2.12.2-2.42.51.9
Locomotion velocity, NPP test4.05.67.12.41.8-2.42.4-2.62.72.2
Intraocular pressure0.60.81.7-0.9-0.90.7-0.61.1-1.3-0.5
Delta distance traveled before/after self-admin1.01.04.3-1.7-2.10.10.1-0.10.10.2
Delta ambulatory time before/after self-admin0.70.83.1-1.5-1.70.20.00.1-0.10.2
Parametrial fat weight2.44.85.9-2.2-1.62.4-2.42.2-2.0-2.4
Pavlov. Cond. lever latency1.41.72.5-1.3-1.11.3-1.31.5-1.6-1.1
Pavlov. Cond. magazine entry latency0.60.81.2-0.30.11.1-0.91.1-1.1-1.0
Pavlov. Cond. change in total contacts0.30.30.6-0.3-0.6-0.80.6-0.50.40.7
Pavlov. Cond. index score0.10.20.40.50.6-0.20.2-0.30.40.2
Pavlov. Cond. latency score0.30.40.50.70.7-0.60.6-0.70.70.5
Pavlov. Cond. lever contacts1.41.72.51.21.0-1.21.3-1.51.61.1
Pavlov. Cond. magazine entry number0.81.01.40.70.4-1.11.1-1.11.21.1
Pavlov. Cond. intertrial magazine entries0.50.60.90.1-0.4-1.00.8-0.90.90.8
Pavlov. Cond. lever-magazine prob. diff.0.10.20.60.60.7-0.10.2-0.30.40.1
Pavlov. Cond. response bias0.10.10.20.20.30.4-0.30.3-0.2-0.4
Pavlov. Cond. lever latency0.60.91.3-0.8-1.2-1.10.7-0.91.00.9
Pavlov. Cond. magazine entry latency0.81.03.31.81.8-0.10.4-0.20.10.2
Pavlov. Cond. change in total contacts0.00.00.10.30.20.10.1-0.10.1-0.0
Pavlov. Cond. index score0.40.51.41.01.20.5-0.20.4-0.5-0.3
Pavlov. Cond. latency score0.30.41.11.01.10.4-0.00.3-0.4-0.2
Pavlov. Cond. lever contacts0.50.62.11.21.40.6-0.30.3-0.3-0.5
Pavlov. Cond. magazine entry number0.20.20.4-0.6-0.6-0.40.2-0.40.50.3
Pavlov. Cond. intertrial magazine entries0.20.30.70.60.80.00.1-0.50.8-0.0
Pavlov. Cond. lever-magazine prob. diff.0.30.41.00.91.00.5-0.20.4-0.5-0.4
Pavlov. Cond. response bias0.30.41.31.01.10.5-0.20.3-0.4-0.4
Time in closed arm before self-admin0.10.10.40.20.60.3-0.30.3-0.4-0.3
Time in closed arm after self-admin0.10.10.4-0.30.00.1-0.10.5-0.60.0
Time in open arm before self-admin0.80.81.90.60.0-0.80.9-1.21.40.8
Time in open arm after self-admin0.60.62.7-1.1-1.6-0.10.1-0.40.50.3
Bone: periosteal estimation0.51.12.0-0.6-0.11.4-1.21.1-1.0-1.3
Bone: periosteal perimeter0.10.20.4-0.5-0.30.6-0.50.20.1-0.6
Bone: post-yield work0.71.01.90.61.01.2-1.20.7-0.5-1.4
Progressive ratio test 1 active lever presses0.10.10.2-0.00.40.1-0.10.3-0.3-0.1
Progressive ratio test 1 breakpoint0.00.10.20.10.50.10.00.2-0.30.0
Progressive ratio test 1 inactive lever presses0.30.31.10.91.1-0.10.3-0.20.10.2
Progressive ratio test 2 active lever presses0.20.21.00.51.00.3-0.0-0.00.1-0.2
Progressive ratio test 2 breakpoint0.10.10.30.10.50.4-0.20.10.1-0.3
Progressive ratio test 2 inactive lever presses1.21.46.01.82.40.5-0.0-0.20.3-0.4
Incentive Sensitization - Responses0.20.20.50.40.70.40.0-0.50.7-0.2
Incentive Sensitization - Breakpoint0.30.30.80.50.70.20.1-0.60.9-0.0
Sum of active levers in priming session hrs 5-60.10.10.2-0.2-0.4-0.2-0.0-0.20.3-0.0
Progressive ratio0.10.10.1-0.1-0.3-0.30.3-0.30.40.3
Food seeking constrained by brief footshock2.12.63.51.40.9-1.71.9-1.71.61.8
Seeking ratio, punishment vs. effort1.01.32.01.41.2-1.01.2-1.00.91.1
Retroperitoneal fat weight6.922.828.0-4.4-3.05.3-5.25.1-4.9-5.0
Reaction time number correct0.50.71.5-0.6-1.2-0.90.7-0.60.60.8
Reaction time mean minus median0.60.81.40.10.51.0-0.81.1-1.2-0.9
Reaction time mean minus median AUC0.10.10.40.20.30.4-0.20.5-0.6-0.2
Reaction time num false alarms0.10.20.50.1-0.1-0.20.4-0.60.70.4
Reaction time num false alarms AUC0.50.61.30.3-0.0-0.70.9-1.01.10.9
Reaction time trials correct on left0.50.71.5-0.6-1.2-0.90.7-0.60.60.8
Reaction time trials on left0.50.71.6-0.6-1.3-1.00.7-0.60.60.9
Reaction time mean0.30.41.00.20.50.7-0.50.8-1.0-0.6
Reaction time mean AUC0.30.51.00.10.50.7-0.50.8-1.0-0.6
Median of all reaction times0.10.20.40.30.60.4-0.30.5-0.6-0.3
Reaction time omissions0.20.30.40.2-0.1-0.60.6-0.60.60.6
Reaction time false alarm rate0.20.30.50.50.6-0.30.5-0.60.70.4
Reaction time premature initiation rate0.20.30.8-0.00.20.3-0.50.8-0.9-0.4
Reaction time premature initiations0.10.10.3-0.3-0.6-0.50.20.1-0.30.3
Std. dev. reaction times0.50.71.60.00.31.0-0.71.1-1.3-0.7
Reaction time trials completed0.50.71.6-0.6-1.3-1.00.7-0.60.60.9
Reaction time trials AUC0.40.61.6-0.6-1.3-0.90.6-0.60.60.8
Run reversals in cocaine runway, females0.30.30.5-0.10.40.4-0.70.6-0.5-0.7
Run reversals in cocaine runway, males0.30.20.6-0.4-0.8-0.40.2-0.50.70.2
Latency to leave start box in cocaine runway8.08.610.7-2.6-1.73.2-3.33.2-3.1-3.2
Latency to leave start box in cocaine runway, F7.88.511.6-2.2-1.13.3-3.43.2-3.1-3.4
Latency to leave start box in cocaine runway, M0.90.81.7-1.3-1.20.7-0.70.8-0.7-0.6
Std. dev. time between licks in bursts0.10.10.3-0.4-0.5-0.10.10.1-0.30.2
Total sessions with >9 infusions0.30.31.10.61.10.7-0.20.2-0.2-0.4
Short access day 1 total inactive lever presses1.31.52.40.21.01.5-1.31.3-1.2-1.5
Short access day 10 total inactive lever presses0.30.31.50.81.20.3-0.00.1-0.2-0.2
Short access day 1 total infusions0.10.10.30.30.40.6-0.20.3-0.3-0.4
Short access day 10 total infusions0.10.10.2-0.00.10.40.30.3-0.50.2
Short access total infusions0.40.41.0-0.3-0.01.0-0.40.8-0.9-0.5
Short access day 1 locomotion0.10.10.2-0.1-0.4-0.50.4-0.20.10.5
Short access day 10 total locomotion2.32.53.21.81.7-1.51.6-1.61.51.5
Short access total locomotion1.92.02.61.41.0-1.51.6-1.41.31.6
One hour access (0.3 mA shock)0.91.13.81.52.0-0.30.6-0.50.50.4
Compulsive drug intake0.40.40.60.3-0.0-0.80.7-0.70.70.7
One hour access (shock baseline)0.50.62.30.91.50.7-0.20.4-0.5-0.4
Social response proportion0.90.91.9-0.5-0.01.4-0.91.1-1.2-1.0
Social responses0.10.10.20.20.2-0.40.4-0.20.10.5
Social time0.30.40.90.41.00.7-0.50.4-0.3-0.6
Soleus weight0.10.30.50.1-0.0-0.50.7-0.50.50.7
Bone: stiffness2.33.65.4-2.3-2.11.6-1.91.8-1.8-1.7
Tibialis anterior weight0.30.91.8-0.50.21.3-1.20.9-0.6-1.3
Time to tail flick, vehicle, before self-admin2.22.25.9-2.4-1.81.1-1.41.0-0.8-1.2
Time to tail flick, vehicle, after self-admin0.00.00.00.10.10.2-0.10.2-0.2-0.1
Time to tail flick, test, before self-admin1.21.21.70.71.31.1-1.11.1-1.1-1.3
Time to tail flick, test, after self-admin2.22.33.70.71.61.9-1.61.3-1.2-1.9
Delta time to tail flick, vehicle, before/after SA1.01.02.71.71.1-0.81.0-0.60.40.8
Delta time to tail flick, test, before/after SA0.30.31.00.71.00.40.1-0.30.4-0.1
Tibia length5.615.718.8-4.1-3.24.2-4.34.0-3.8-4.1
Ambulatory time before self-admin0.10.10.40.3-0.1-0.60.2-0.40.40.3
Ambulatory time after self-admin1.21.35.7-1.8-2.4-0.3-0.0-0.00.10.2
Bone: tissue strength0.10.10.10.20.40.0-0.1-0.20.4-0.2
Total heroin consumption0.30.31.6-0.7-1.3-0.1-0.30.00.1-0.2
Bone: trabecular number1.42.23.10.10.81.7-1.61.7-1.8-1.7
Bone: trabecular spacing1.01.23.6-1.3-1.9-0.80.7-0.80.80.9
Bone: trabecular thickness1.61.92.6-1.0-0.51.5-1.61.6-1.6-1.6
Bone: trabecular tissue density0.20.21.1-0.7-1.0-0.30.0-0.20.30.1
Water consumed over 24 hours0.50.61.81.01.30.9-0.30.4-0.4-0.5
Number of responses in last shaping day0.30.41.40.71.20.2-0.30.3-0.3-0.4