LOC102551352

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	LOC102551352	0.09	0.05	2.6e-07	0.02	0.04	0.02	0.04	1.7e-03	5.2e-05	1.6e-03	8.2e-05
2	Liver	alternative TSS	XR_351151.4	0.24	0.13	4.5e-05	0.01	0.03	0.02	0.01	9.2e-03	2.4e-04	9.7e-04	1.3e-02
3	Liver	alternative TSS	XR_005499739.1	0.23	0.13	6.1e-05	0.01	0.03	0.02	0.01	9.3e-03	4.2e-04	1.2e-03	1.9e-02
4	Liver	isoform ratio	XR_351151.4	0.1	0.06	1.2e-04	0.02	0.02	0.02	0.02	1.5e-03	3.2e-03	4.9e-03	4.0e-03
5	Liver	isoform ratio	XR_005499739.1	0.09	0.06	2.6e-04	0.02	0.01	0.01	0.01	3.1e-03	8.2e-03	1.2e-02	9.8e-03
6	Liver	intron excision ratio	chr1_252462253_252462474	0.07	0.05	1.8e-03	0.03	0.02	0.01	0.02	4.6e-04	3.5e-03	1.1e-02	1.8e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	1.0	1.7	2.8	-1.7	-1.3	1.2	1.1	-1.1	1.1
Area under the delay curve	0.5	0.5	1.7	-1.3	-0.4	0.4	0.6	-0.6	0.6
BMI with tail	0.6	2.1	12.1	-3.5	-0.5	0.4	0.2	-0.2	0.2
BMI without tail	0.6	1.2	5.5	-2.3	-1.0	0.8	0.3	-0.3	0.3
Body weight	2.0	8.3	26.2	-5.1	-3.0	2.8	1.5	-1.5	1.5
Weight adjusted by age	0.5	0.6	1.3	-1.1	-0.8	0.8	0.6	-0.6	0.6
Bone surface	0.2	0.3	0.6	-0.8	-0.7	0.6	0.3	-0.3	0.3
Bone volume	1.5	2.6	3.9	-2.0	-1.8	1.7	1.4	-1.4	1.4
Breakpoint value in progressive ratio session	0.3	0.3	0.5	-0.5	-0.4	0.3	0.7	-0.7	0.7
Number of licking bursts	2.4	2.8	3.4	-1.0	-1.7	1.7	1.8	-1.8	1.8
Context. condit. distance diff. score	0.2	0.3	1.4	1.2	0.2	-0.2	-0.3	0.3	-0.3
Locomotion velocity, session 1	0.8	0.9	1.9	1.4	-0.4	0.5	1.0	-1.0	1.0
Locomotion distance, session 1	0.2	0.3	0.6	0.3	-0.7	0.8	0.3	-0.3	0.3
Locomotion velocity, session 2	0.1	0.1	0.2	0.2	0.2	-0.1	-0.5	0.5	-0.5
Locomotion distance, session 2	2.4	3.4	5.6	-0.3	-2.3	2.4	1.7	-1.7	1.7
Locomotion velocity, session 3	0.5	0.6	0.6	0.8	-0.6	0.7	0.8	-0.8	0.8
Locomotion distance, session 3	2.9	3.2	4.3	0.8	-2.0	2.1	1.8	-1.8	1.8
Stereotopy head waving bouts, day 3	1.3	1.6	3.0	0.4	1.7	-1.7	-1.1	1.1	-1.1
Stereotopy head waving duration, day 3	1.9	2.3	4.2	0.9	2.1	-2.0	-1.2	1.2	-1.2
Locomotion velocity, session 7	0.9	1.0	1.4	0.8	-0.8	0.9	1.2	-1.2	1.2
Locomotion distance, session 7	0.8	1.0	1.5	0.8	-1.1	1.2	1.0	-1.0	1.0
Stereotopy head waving bouts, day 7	0.2	0.2	0.7	0.8	0.2	-0.1	0.4	-0.4	0.4
Stereotopy head waving duration, day 7	0.1	0.2	0.5	0.7	0.0	-0.0	0.4	-0.4	0.4
Locomotion velocity, session 8	0.1	0.1	0.3	0.5	-0.1	0.2	-0.2	0.2	-0.2
Locomotion distance, session 8	0.6	0.9	1.7	0.6	-1.3	1.3	0.7	-0.7	0.7
Degree of sensitization distance	1.0	1.0	1.5	0.3	1.2	-1.2	-1.0	1.0	-1.0
Degree of sensitization stereotypy	0.9	0.9	1.1	1.0	-0.8	0.9	1.0	-1.0	1.0
Conditioned locomotion	1.3	1.5	2.1	0.4	-1.4	1.4	1.2	-1.2	1.2
Cocaine response after cond. corrected	3.5	4.0	5.7	1.6	2.4	-2.3	-1.8	1.8	-1.8
Cocaine response after cond. not corrected	3.9	4.3	5.9	2.0	2.4	-2.3	-1.9	1.9	-1.9
Cocaine response before conditioning	0.0	0.1	0.3	0.6	0.0	0.0	0.0	-0.0	0.0
Saline control response	0.4	0.6	1.6	1.2	0.5	-0.5	-0.7	0.7	-0.7
Bone: connectivity density	0.1	0.1	0.6	-0.8	-0.1	0.0	-0.1	0.1	-0.1
Bone: cortical apparent density	0.2	0.2	0.6	0.8	0.1	0.0	-0.5	0.5	-0.5
Bone: cortical area	2.6	3.9	5.6	-0.1	-2.3	2.4	2.0	-2.0	2.0
Bone: cortical porosity	0.1	0.1	0.2	0.4	0.4	-0.5	-0.1	0.1	-0.1
Bone: cortical porosity	0.1	0.2	0.2	0.1	-0.4	0.3	0.5	-0.5	0.5
Bone: cortical thickness	1.8	3.0	5.3	0.5	-2.2	2.3	1.6	-1.6	1.6
Bone: cortical thickness	1.6	1.8	3.8	0.2	-1.9	2.0	1.1	-1.1	1.1
Bone: cortical tissue density	0.2	0.3	0.6	0.8	0.2	-0.1	-0.6	0.6	-0.6
Condit. Reinf. active minus inactive responses	0.5	0.6	1.9	1.4	0.5	-0.4	0.6	-0.6	0.6
Condit. Reinf. active-inactive response ratio	0.9	0.9	1.7	1.3	1.3	-1.3	-0.5	0.5	-0.5
Condit. Reinf. active responses	1.0	1.2	2.2	1.5	-0.3	0.4	1.3	-1.3	1.3
Condit. Reinf. inactive responses	1.2	1.4	2.0	0.5	-1.1	1.1	1.4	-1.4	1.4
Incentive salience index mean	0.6	0.7	2.4	1.5	0.3	-0.3	0.7	-0.7	0.7
Condit. Reinf. lever presses	0.6	0.8	1.4	0.4	-0.5	0.5	1.2	-1.2	1.2
Condit. Reinf. active minus inactive responses	2.0	2.5	6.6	2.6	0.1	-0.1	1.7	-1.7	1.7
Condit. Reinf. active-inactive response ratio	1.5	1.6	6.4	2.5	0.8	-0.7	0.8	-0.8	0.8
Condit. Reinf. active responses	1.9	2.6	4.1	2.0	-0.4	0.5	1.9	-1.9	1.9
Condit. Reinf. inactive responses	1.1	1.3	1.9	0.3	-1.1	1.0	1.4	-1.4	1.4
Condit. Reinf. lever presses	2.2	3.0	4.0	2.0	-1.0	1.1	2.0	-2.0	2.0
Condit. Reinf. lever reinforcers received	1.6	2.3	5.2	2.3	-0.2	0.2	1.7	-1.7	1.7
Conditioned reinforcement - actives	0.6	0.6	1.0	-0.4	0.9	-1.0	-0.7	0.7	-0.7
Conditioned reinforcement - inactives	1.8	2.1	3.3	-0.3	-1.8	1.8	1.4	-1.4	1.4
Conditioned locomotion	1.9	2.3	4.5	-2.1	1.1	-1.2	-1.5	1.5	-1.5
Patch foraging indifference point 0 sec	0.2	0.3	0.5	0.6	0.3	-0.2	-0.7	0.7	-0.7
Patch foraging indifference point AUC	3.7	4.3	5.2	0.1	-2.2	2.2	2.3	-2.3	2.3
Delay disc. indifference point, 0s delay	0.7	0.7	1.3	-1.2	-0.9	0.8	0.7	-0.7	0.7
Delay disc. indifference point, 16s delay	0.1	0.1	0.2	-0.4	0.5	-0.5	-0.0	0.0	-0.0
Delay disc. indifference point, 2s delay	0.8	0.9	1.2	-1.1	-1.0	0.9	0.9	-0.9	0.9
Delay disc. indifference point, 24s delay	1.1	1.1	1.3	-1.2	-1.0	0.9	1.0	-1.0	1.0
Delay disc. indifference point, 4s delay	0.6	0.6	0.8	-0.6	-0.7	0.6	0.9	-0.9	0.9
Delay disc. indifference point, 8s delay	0.5	0.5	2.5	-1.6	-0.1	0.1	0.3	-0.3	0.3
Indifference point function ln k	1.3	1.9	2.3	0.1	1.5	-1.5	-1.5	1.5	-1.5
Indifference point function log k	1.3	1.9	2.3	0.1	1.5	-1.5	-1.5	1.5	-1.5
Patch foraging total patch changes 0 sec	0.1	0.1	0.3	0.6	-0.3	0.3	-0.1	0.1	-0.1
Patch foraging total patch changes 12 sec	2.1	2.7	3.5	0.2	-1.9	1.9	1.7	-1.7	1.7
Patch foraging total patch changes 18 sec	2.1	2.7	3.4	0.8	-1.8	1.8	1.7	-1.7	1.7
Patch foraging total patch changes 24 sec	2.4	2.9	4.2	-0.1	-2.0	2.0	1.8	-1.8	1.8
Patch foraging total patch changes 6 sec	0.6	0.9	1.9	-0.0	-1.4	1.4	0.7	-0.7	0.7
Patch foraging time to switch 0 sec	1.1	1.7	2.1	-0.2	1.4	-1.4	-1.5	1.5	-1.5
Patch foraging water rate 0 sec	0.6	1.0	1.5	-0.1	-1.2	1.2	1.0	-1.0	1.0
Patch foraging water rate 12 sec	0.1	0.1	0.6	-0.8	0.3	-0.3	-0.1	0.1	-0.1
Patch foraging water rate 18 sec	0.2	0.2	0.4	-0.5	0.2	-0.2	-0.6	0.6	-0.6
Patch foraging water rate 24 sec	0.2	0.2	1.2	-1.1	-0.3	0.2	-0.1	0.1	-0.1
Patch foraging water rate 6 sec	0.1	0.1	0.2	-0.4	0.0	-0.0	-0.5	0.5	-0.5
Seeking ratio, delayed vs. immediate footshock	0.3	0.4	1.1	-1.1	0.1	-0.2	-0.6	0.6	-0.6
Distance traveled before self-admin	0.3	0.3	0.7	0.8	-0.8	0.8	-0.0	0.0	-0.0
Distance traveled after self-admin	0.7	0.8	1.3	-1.0	-0.2	0.1	-1.2	1.2	-1.2
Extensor digitorum longus weight	2.4	9.5	12.0	-1.1	-3.5	3.4	3.3	-3.3	3.3
Bone: elastic displacement	0.0	0.1	0.1	0.2	0.3	-0.3	-0.2	0.2	-0.2
Bone: elastic work	0.2	0.2	0.9	-1.0	-0.5	0.5	0.1	-0.1	0.1
Bone: endosteal estimation	0.2	0.5	3.1	-1.8	-0.0	-0.1	-0.0	0.0	-0.0
Bone: endosteal perimeter	1.2	2.4	2.8	-1.7	-1.7	1.6	1.5	-1.5	1.5
Epididymis fat weight	3.3	7.6	12.8	-3.6	-2.4	2.2	2.7	-2.7	2.7
Delta time in closed arm before/after self-admin	1.0	0.9	1.2	1.1	0.7	-0.6	-1.1	1.1	-1.1
Delta time in open arm before/after self-admin	0.2	0.1	0.2	-0.5	-0.2	0.1	0.4	-0.4	0.4
Diff in mean of infusions in LGA sessions	2.6	2.9	6.0	1.8	2.4	-2.4	-0.9	0.9	-0.9
Delay discount exponential model param	0.7	0.7	2.0	1.4	0.6	-0.5	-0.7	0.7	-0.7
Extinction: sum of active levers before priming	0.1	0.1	0.3	0.5	0.3	-0.3	-0.3	0.3	-0.3
Active lever presses in extinction session 6	2.8	2.7	3.9	0.1	-1.9	2.0	1.7	-1.7	1.7
Bone: final force	0.1	0.2	1.2	-1.1	-0.4	0.3	-0.1	0.1	-0.1
Bone: final moment	0.2	0.3	1.5	-1.2	-0.4	0.4	-0.1	0.1	-0.1
Food consumed during 24 hour testing period	0.1	0.1	0.3	-0.5	-0.2	0.2	-0.1	0.1	-0.1
Glucose	2.9	4.3	7.6	-2.8	-2.3	2.2	1.6	-1.6	1.6
Heart weight	0.9	1.3	7.4	2.7	0.4	-0.3	0.1	-0.1	0.1
Delay discount hyperbolic model param	0.6	0.7	1.9	1.4	0.6	-0.5	-0.7	0.7	-0.7
Intermittent access intake day 1-15 change	0.3	0.3	1.4	-1.2	-0.0	-0.1	0.3	-0.3	0.3
Intermittent access intake escalation	0.4	0.3	1.9	-1.4	-0.2	0.1	0.2	-0.2	0.2
Intermittent access intake escalation 2	0.6	0.6	3.8	-2.0	-0.0	-0.1	0.0	-0.0	0.0
Intermitt. access day 1 inactive lever presses	4.3	4.6	5.3	-1.2	-2.3	2.3	2.3	-2.3	2.3
Intermitt. access day 15 inactive lever presses	0.1	0.2	0.3	-0.1	-0.2	0.2	0.5	-0.5	0.5
Intermitt. access escalation Index	0.4	0.3	1.6	-1.3	-0.2	0.2	0.2	-0.2	0.2
Intermittent access day 1 total infusions	0.3	0.4	0.6	0.2	-0.5	0.4	0.8	-0.8	0.8
Intermittent access day 15 total infusions	0.6	0.6	0.9	-0.9	-0.6	0.5	0.9	-0.9	0.9
Intermittent access terminal intake (last 3 days)	0.4	0.5	2.1	-1.4	-0.0	-0.1	0.5	-0.5	0.5
Intermittent access total infusions	0.5	0.5	0.8	-0.9	-0.6	0.5	0.8	-0.8	0.8
Intermittent access day 1 locomotion	0.2	0.2	0.3	-0.4	0.5	-0.5	-0.5	0.5	-0.5
Intermittent access day 15 total locomotion	0.5	0.5	0.6	-0.7	-0.8	0.7	0.7	-0.7	0.7
Intermittent access total locomotion	0.6	0.7	1.3	-1.1	0.7	-0.7	-0.7	0.7	-0.7
Intermittent access standard deviation	1.4	1.5	2.9	-1.7	-1.3	1.2	1.0	-1.0	1.0
Left kidney weight	0.9	2.6	9.7	-3.1	-0.6	0.5	-1.3	1.3	-1.3
Right kidney weight	0.6	1.7	8.3	-2.9	-0.8	0.7	-0.6	0.6	-0.6
Cocaine induced anxiety	0.4	0.5	1.0	0.1	0.1	-0.1	-1.0	1.0	-1.0
Post-drug Anxiety	0.2	0.2	0.5	-0.1	0.3	-0.2	-0.7	0.7	-0.7
Baseline Anxiety	2.0	2.1	3.5	-0.2	-1.0	1.0	1.9	-1.9	1.9
Tail length	1.6	4.8	8.2	-0.8	-2.9	2.8	2.0	-2.0	2.0
Length with tail	1.8	6.7	10.7	-2.9	-3.3	3.2	1.9	-1.9	1.9
Length without tail	1.0	2.1	5.0	-2.2	-1.5	1.5	1.0	-1.0	1.0
Times rat made contact with spout	1.9	2.2	3.5	-0.8	-1.9	1.9	1.4	-1.4	1.4
Lifetime Intake	0.4	0.5	0.5	-0.7	-0.6	0.5	0.7	-0.7	0.7
Liver weight, left	2.5	4.0	5.1	-0.3	-2.3	2.2	2.1	-2.1	2.1
Liver weight, right	2.8	4.6	12.3	-3.5	-2.2	2.1	1.5	-1.5	1.5
Locomotor activity	0.0	0.1	0.1	0.2	-0.2	0.3	-0.3	0.3	-0.3
Locomotor testing distance	0.5	0.9	1.6	0.3	0.5	-0.5	-1.3	1.3	-1.3
Locomotor testing rearing	0.9	1.4	2.3	-0.1	0.9	-0.9	-1.5	1.5	-1.5
Locomotion in novel chamber	0.8	0.9	2.3	1.5	0.8	-0.8	-0.8	0.8	-0.8
Locomotion in novel chamber post-restriction	1.0	1.2	2.2	0.2	1.5	-1.5	-1.0	1.0	-1.0
Fecal boli incidents, locomotor time 1	0.2	0.2	0.6	-0.8	-0.4	0.4	0.3	-0.3	0.3
Change in fecal boli incidents, locomotor task	0.2	0.2	0.7	0.8	0.0	0.0	0.4	-0.4	0.4
Time >=10cm from walls, locomotor time 1	0.5	0.5	0.7	0.2	0.5	-0.6	-0.9	0.9	-0.9
Bouts of movement, locomotor time 1	0.1	0.1	0.1	-0.4	0.2	-0.3	0.4	-0.4	0.4
Total resting periods, locomotor time 1	0.3	0.3	0.5	-0.6	-0.2	0.2	0.7	-0.7	0.7
Rest time, locomotor task time 1	0.1	0.1	0.4	0.6	-0.2	0.3	0.3	-0.3	0.3
Distance moved, locomotor task time 1	0.4	0.5	1.7	-1.3	-0.5	0.5	0.4	-0.4	0.4
Vertical activity count, locomotor time 1	0.2	0.2	0.5	0.7	0.4	-0.4	-0.2	0.2	-0.2
Time >=10cm from walls, locomotor time 2	1.0	1.0	1.7	0.2	-1.3	1.3	1.0	-1.0	1.0
Bouts of movement, locomotor time 2	0.3	0.3	1.0	0.2	0.9	-1.0	-0.1	0.1	-0.1
Total resting periods, locomotor time 2	0.3	0.3	1.0	0.1	0.9	-1.0	-0.3	0.3	-0.3
Rest time, locomotor task time 2	1.0	1.1	1.8	-0.5	0.7	-0.7	-1.3	1.3	-1.3
Distance moved, locomotor task time 2	0.4	0.4	0.7	0.6	-0.3	0.3	0.8	-0.8	0.8
Vertical activity count, locomotor time 2	1.2	1.3	1.6	0.8	-1.0	1.1	1.3	-1.3	1.3
Light reinforcement 1	0.2	0.4	1.9	1.4	0.4	-0.3	0.1	-0.1	0.1
Light reinforcement 2	0.3	0.4	0.8	0.9	-0.2	0.3	0.7	-0.7	0.7
Bone: marrow area	0.2	0.5	3.0	-1.7	-0.0	-0.1	-0.0	0.0	-0.0
Bone: maximum diameter	2.6	4.7	6.1	-0.5	-2.5	2.5	2.3	-2.3	2.3
Bone: maximum force	0.1	0.1	0.3	-0.6	-0.5	0.5	0.2	-0.2	0.2
Bone: maximum moment	0.1	0.2	0.5	-0.7	-0.6	0.5	0.2	-0.2	0.2
Mean time between licks in bursts	1.8	2.6	5.9	0.5	2.4	-2.4	-1.1	1.1	-1.1
Mean num. licks in bursts	0.9	1.0	1.6	0.4	0.8	-0.7	-1.3	1.3	-1.3
Cd content in liver	4.5	5.0	9.8	3.1	2.3	-2.2	-1.8	1.8	-1.8
Co content in liver	1.8	2.1	2.8	0.8	1.3	-1.2	-1.7	1.7	-1.7
Cu content in liver	0.2	0.2	1.4	-1.2	0.1	-0.1	-0.0	0.0	-0.0
Fe content in liver	0.2	0.3	1.1	1.0	0.5	-0.4	-0.3	0.3	-0.3
K content in liver	0.8	0.7	2.3	-1.5	-0.5	0.5	0.7	-0.7	0.7
Mg content in liver	1.9	1.9	2.5	-1.4	-1.0	1.0	1.6	-1.6	1.6
Mn content in liver	1.0	1.1	1.2	0.9	-1.0	1.0	1.1	-1.1	1.1
Na content in liver	0.9	0.9	1.6	0.7	-0.4	0.4	1.3	-1.3	1.3
Rb content in liver	0.6	0.8	1.9	0.5	1.4	-1.4	-0.4	0.4	-0.4
Se content in liver	1.0	1.3	1.8	-0.0	1.3	-1.3	-1.2	1.2	-1.2
Sr content in liver	3.4	3.1	4.2	-0.1	1.7	-1.8	-2.1	2.1	-2.1
Zn content in liver	0.1	0.1	0.3	0.6	0.0	-0.0	0.3	-0.3	0.3
Bone: minimum diameter	1.0	2.0	2.3	-0.9	-1.5	1.4	1.5	-1.5	1.5
Time in familiar zone, hab. session 1	4.4	4.1	5.2	-0.3	2.3	-2.3	-2.2	2.2	-2.2
Time in novel zone, hab. session 1	5.8	5.6	6.8	-0.3	-2.6	2.6	2.6	-2.6	2.6
Total zone transitions, hab. session 1	1.9	2.7	4.9	0.3	-2.2	2.2	1.5	-1.5	1.5
Total locomotion distance, hab. session 1	0.7	1.0	1.3	0.3	-1.0	1.0	1.1	-1.1	1.1
Locomotion velocity, hab. session 1	0.6	0.8	1.0	0.8	-0.9	0.9	1.0	-1.0	1.0
Time in familiar zone, hab. session 2	1.3	1.4	1.8	-0.7	-1.1	1.1	1.3	-1.3	1.3
Time in novel zone, hab. session 2	1.0	1.0	1.3	0.4	1.0	-1.0	-1.1	1.1	-1.1
Total zone transitions, hab. session 2	0.8	1.0	1.4	-0.2	-1.2	1.2	1.0	-1.0	1.0
Total locomotion distance, hab. session 2	0.9	1.2	1.7	-0.1	-1.1	1.1	1.3	-1.3	1.3
Locomotion velocity, hab. session 2	1.0	1.3	1.8	-0.0	-1.1	1.1	1.3	-1.3	1.3
Novel to familiar place preference ratio	0.0	0.0	0.1	-0.3	0.1	-0.2	-0.1	0.1	-0.1
Novelty place preference	0.1	0.1	0.6	-0.8	0.0	-0.1	0.0	-0.0	0.0
Time in novel zone, NPP test	0.2	0.2	0.8	-0.9	-0.1	0.1	0.3	-0.3	0.3
Total zone transitions, NPP test	3.8	5.5	8.2	-0.1	-2.8	2.9	2.4	-2.4	2.4
Total locomotion distance, NPP test	2.5	3.4	4.2	0.0	-2.0	2.0	2.1	-2.1	2.1
Locomotion velocity, NPP test	1.6	2.2	2.9	0.1	-1.7	1.7	1.6	-1.6	1.6
Intraocular pressure	0.7	0.9	1.3	-0.0	-1.0	0.9	1.1	-1.1	1.1
Delta distance traveled before/after self-admin	2.4	2.6	3.2	-1.6	1.3	-1.3	-1.8	1.8	-1.8
Delta ambulatory time before/after self-admin	1.3	1.5	2.4	-1.5	1.0	-1.1	-1.2	1.2	-1.2
Parametrial fat weight	0.9	1.8	3.1	-1.8	-1.3	1.2	1.2	-1.2	1.2
Pavlov. Cond. lever latency	0.0	0.0	0.1	0.0	-0.0	0.0	-0.2	0.2	-0.2
Pavlov. Cond. magazine entry latency	0.6	0.8	1.0	-0.8	-0.7	0.6	1.0	-1.0	1.0
Pavlov. Cond. change in total contacts	0.5	0.6	0.8	-0.9	-0.6	0.6	0.8	-0.8	0.8
Pavlov. Cond. index score	0.8	1.0	1.2	-0.8	-0.9	0.8	1.1	-1.1	1.1
Pavlov. Cond. latency score	0.5	0.6	0.7	-0.8	-0.7	0.6	0.8	-0.8	0.8
Pavlov. Cond. lever contacts	0.1	0.1	0.2	-0.3	-0.0	-0.0	0.5	-0.5	0.5
Pavlov. Cond. magazine entry number	0.6	0.7	1.6	1.3	0.5	-0.5	-0.8	0.8	-0.8
Pavlov. Cond. intertrial magazine entries	0.3	0.3	0.5	0.7	-0.6	0.6	0.5	-0.5	0.5
Pavlov. Cond. lever-magazine prob. diff.	1.0	1.2	1.7	-0.8	-1.0	0.9	1.3	-1.3	1.3
Pavlov. Cond. response bias	0.4	0.5	0.9	-0.9	-0.4	0.3	0.8	-0.8	0.8
Pavlov. Cond. lever latency	2.3	3.1	4.8	-1.3	1.1	-1.2	-2.2	2.2	-2.2
Pavlov. Cond. magazine entry latency	0.8	1.0	1.2	-0.5	-1.0	0.9	1.1	-1.1	1.1
Pavlov. Cond. change in total contacts	1.3	1.8	3.0	1.0	-0.8	0.8	1.7	-1.7	1.7
Pavlov. Cond. index score	1.3	1.7	2.6	0.6	-1.0	1.0	1.6	-1.6	1.6
Pavlov. Cond. latency score	1.5	1.9	2.8	0.2	-1.2	1.2	1.7	-1.7	1.7
Pavlov. Cond. lever contacts	2.6	3.5	4.9	1.4	-1.5	1.5	2.2	-2.2	2.2
Pavlov. Cond. magazine entry number	0.9	1.2	1.4	0.7	1.1	-1.0	-1.2	1.2	-1.2
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.8	0.9	-0.0	0.1	0.1	-0.1	0.1
Pavlov. Cond. lever-magazine prob. diff.	1.5	1.9	2.9	0.4	-1.1	1.1	1.7	-1.7	1.7
Pavlov. Cond. response bias	1.7	2.4	3.4	1.2	-1.0	1.1	1.9	-1.9	1.9
Time in closed arm before self-admin	0.5	0.5	0.9	-0.9	-0.7	0.7	0.7	-0.7	0.7
Time in closed arm after self-admin	0.5	0.5	0.8	0.8	0.9	-0.9	-0.5	0.5	-0.5
Time in open arm before self-admin	0.7	0.8	1.3	0.2	-1.1	1.1	0.8	-0.8	0.8
Time in open arm after self-admin	0.3	0.3	0.5	-0.4	-0.5	0.4	0.7	-0.7	0.7
Bone: periosteal estimation	0.7	1.5	2.0	-1.4	-1.4	1.3	1.1	-1.1	1.1
Bone: periosteal perimeter	2.8	4.6	6.3	-1.6	-2.5	2.5	2.1	-2.1	2.1
Bone: post-yield work	0.2	0.3	0.5	0.6	-0.1	0.1	0.7	-0.7	0.7
Progressive ratio test 1 active lever presses	0.1	0.1	0.2	-0.4	0.2	-0.3	-0.3	0.3	-0.3
Progressive ratio test 1 breakpoint	0.0	0.0	0.0	-0.1	0.2	-0.2	-0.1	0.1	-0.1
Progressive ratio test 1 inactive lever presses	2.1	2.3	3.0	-0.5	-1.5	1.5	1.7	-1.7	1.7
Progressive ratio test 2 active lever presses	0.7	0.8	1.3	-1.1	1.0	-1.1	-0.6	0.6	-0.6
Progressive ratio test 2 breakpoint	0.7	0.8	1.4	-1.0	1.1	-1.2	-0.6	0.6	-0.6
Progressive ratio test 2 inactive lever presses	0.5	0.6	2.6	-1.6	-0.0	-0.1	0.5	-0.5	0.5
Incentive Sensitization - Responses	0.2	0.2	1.0	-1.0	0.4	-0.5	0.0	-0.0	0.0
Incentive Sensitization - Breakpoint	0.2	0.2	1.1	-1.0	0.3	-0.4	0.1	-0.1	0.1
Sum of active levers in priming session hrs 5-6	1.1	1.1	1.5	0.3	-1.2	1.2	1.1	-1.1	1.1
Progressive ratio	0.2	0.3	1.1	1.1	0.4	-0.4	-0.2	0.2	-0.2
Food seeking constrained by brief footshock	0.2	0.3	0.8	0.9	-0.2	0.3	0.5	-0.5	0.5
Seeking ratio, punishment vs. effort	0.4	0.5	0.6	-0.4	-0.7	0.7	0.7	-0.7	0.7
Retroperitoneal fat weight	1.5	5.0	29.0	-5.4	-0.4	0.2	0.5	-0.5	0.5
Reaction time number correct	0.5	0.7	3.0	-1.7	-0.3	0.2	-0.6	0.6	-0.6
Reaction time mean minus median	0.4	0.5	0.7	-0.2	0.8	-0.8	-0.7	0.7	-0.7
Reaction time mean minus median AUC	0.6	0.8	0.9	-0.8	0.8	-0.8	-1.0	1.0	-1.0
Reaction time num false alarms	1.9	2.6	3.2	0.7	-1.7	1.7	1.8	-1.8	1.8
Reaction time num false alarms AUC	1.4	1.9	2.1	1.2	-1.4	1.4	1.4	-1.4	1.4
Reaction time trials correct on left	0.5	0.7	3.0	-1.7	-0.3	0.2	-0.6	0.6	-0.6
Reaction time trials on left	0.5	0.7	2.8	-1.7	-0.2	0.1	-0.7	0.7	-0.7
Reaction time mean	0.8	1.2	1.6	-0.3	1.0	-1.0	-1.3	1.3	-1.3
Reaction time mean AUC	1.1	1.5	1.9	-0.0	1.4	-1.4	-1.3	1.3	-1.3
Median of all reaction times	0.9	1.2	1.8	-0.4	0.9	-0.9	-1.3	1.3	-1.3
Reaction time omissions	1.7	2.3	2.9	-0.1	1.6	-1.7	-1.7	1.7	-1.7
Reaction time false alarm rate	1.8	2.5	3.8	2.0	-1.1	1.2	1.7	-1.7	1.7
Reaction time premature initiation rate	1.6	2.1	4.6	-0.5	-2.1	2.1	1.0	-1.0	1.0
Reaction time premature initiations	1.3	1.9	4.2	-1.4	-2.1	2.0	0.5	-0.5	0.5
Std. dev. reaction times	0.5	0.8	1.0	-0.3	1.0	-1.0	-0.9	0.9	-0.9
Reaction time trials completed	0.5	0.7	2.8	-1.7	-0.2	0.1	-0.7	0.7	-0.7
Reaction time trials AUC	0.5	0.7	2.9	-1.7	-0.3	0.2	-0.6	0.6	-0.6
Run reversals in cocaine runway, females	2.7	2.6	3.7	-0.7	1.4	-1.4	-1.9	1.9	-1.9
Run reversals in cocaine runway, males	0.1	0.1	0.1	0.3	0.2	-0.2	-0.2	0.2	-0.2
Latency to leave start box in cocaine runway	0.1	0.1	0.6	0.8	0.0	0.0	-0.2	0.2	-0.2
Latency to leave start box in cocaine runway, F	0.7	0.7	1.6	1.3	0.4	-0.3	-0.9	0.9	-0.9
Latency to leave start box in cocaine runway, M	0.3	0.3	0.4	0.1	-0.5	0.5	0.6	-0.6	0.6
Std. dev. time between licks in bursts	0.2	0.2	0.3	0.3	0.2	-0.3	0.6	-0.6	0.6
Total sessions with >9 infusions	0.5	0.6	2.0	-1.4	-0.9	0.8	-0.1	0.1	-0.1
Short access day 1 total inactive lever presses	1.2	1.4	2.4	-1.0	-1.6	1.5	0.9	-0.9	0.9
Short access day 10 total inactive lever presses	1.7	1.9	1.9	-1.4	-1.3	1.3	1.4	-1.4	1.4
Short access day 1 total infusions	0.9	1.0	2.2	-1.5	-1.4	1.3	0.2	-0.2	0.2
Short access day 10 total infusions	0.5	0.6	0.8	-0.3	-0.7	0.7	0.9	-0.9	0.9
Short access total infusions	0.2	0.2	0.3	-0.5	-0.6	0.5	0.4	-0.4	0.4
Short access day 1 locomotion	0.6	0.7	2.9	-1.7	-0.8	0.7	0.2	-0.2	0.2
Short access day 10 total locomotion	1.0	1.2	6.7	-2.6	0.1	-0.2	-0.3	0.3	-0.3
Short access total locomotion	0.7	0.8	1.6	-1.3	0.6	-0.6	-0.9	0.9	-0.9
One hour access (0.3 mA shock)	0.8	0.9	3.5	-1.9	-0.5	0.4	0.7	-0.7	0.7
Compulsive drug intake	0.1	0.1	0.5	0.7	-0.2	0.2	0.1	-0.1	0.1
One hour access (shock baseline)	0.4	0.5	2.4	-1.5	-0.3	0.2	0.4	-0.4	0.4
Social response proportion	2.9	3.2	10.9	-3.3	0.6	-0.7	-1.6	1.6	-1.6
Social responses	1.2	1.5	4.1	-2.0	0.9	-1.0	-1.0	1.0	-1.0
Social time	2.6	3.5	4.8	-1.8	1.2	-1.3	-2.2	2.2	-2.2
Soleus weight	1.0	3.0	11.4	-3.4	-1.7	1.6	0.6	-0.6	0.6
Bone: stiffness	0.0	0.0	0.0	0.1	-0.0	0.0	-0.1	0.1	-0.1
Tibialis anterior weight	0.7	2.5	3.2	0.1	-1.7	1.7	1.8	-1.8	1.8
Time to tail flick, vehicle, before self-admin	0.5	0.5	1.1	-1.1	-0.9	0.8	0.5	-0.5	0.5
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.1	-0.1	-0.1	0.1	-0.3	0.3	-0.3
Time to tail flick, test, before self-admin	0.1	0.1	0.1	-0.3	-0.0	0.0	-0.3	0.3	-0.3
Time to tail flick, test, after self-admin	0.2	0.2	0.3	-0.1	-0.5	0.5	0.6	-0.6	0.6
Delta time to tail flick, vehicle, before/after SA	0.7	0.7	0.7	0.8	0.8	-0.8	-0.8	0.8	-0.8
Delta time to tail flick, test, before/after SA	0.2	0.2	0.2	-0.2	-0.5	0.5	0.5	-0.5	0.5
Tibia length	0.3	0.8	2.2	-1.5	-0.8	0.8	-0.6	0.6	-0.6
Ambulatory time before self-admin	0.5	0.5	1.5	0.4	-1.2	1.2	0.1	-0.1	0.1
Ambulatory time after self-admin	1.3	1.4	4.0	-2.0	-1.1	1.1	-0.8	0.8	-0.8
Bone: tissue strength	0.6	0.6	1.2	0.4	1.1	-1.1	-0.5	0.5	-0.5
Total heroin consumption	0.4	0.5	1.0	-0.1	-0.2	0.1	1.0	-1.0	1.0
Bone: trabecular number	0.3	0.5	1.9	-1.4	-0.4	0.3	0.5	-0.5	0.5
Bone: trabecular spacing	0.7	0.9	1.1	1.1	-0.9	1.0	0.9	-0.9	0.9
Bone: trabecular thickness	5.5	6.6	8.3	-2.9	-2.8	2.7	2.3	-2.3	2.3
Bone: trabecular tissue density	0.3	0.4	0.6	-0.2	-0.8	0.8	0.7	-0.7	0.7
Water consumed over 24 hours	0.5	0.7	2.0	-1.4	-1.0	1.0	-0.0	0.0	-0.0
Number of responses in last shaping day	0.3	0.3	0.4	-0.1	0.4	-0.4	-0.6	0.6	-0.6