Hub : Genes

LOC102550562

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	isoform ratio	XR_005499321.1	0.06	0.04	3.4e-05	0.03	0.03	0.03	0.03	1.8e-04	3.1e-04	3.7e-04	1.8e-04
2	Adipose	gene expression	LOC102550562	0.1	0.06	3.5e-09	0.04	0.05	0.04	0.04	1.5e-05	7.5e-06	1.3e-05	3.3e-05
3	Adipose	alternative TSS	XR_005499320.1	0.06	0.04	3.3e-06	0.03	0.04	0.03	0.04	1.2e-04	7.3e-05	1.5e-04	7.8e-05
4	Adipose	alternative TSS	XR_005499321.1	0.07	0.04	1.7e-06	0.03	0.04	0.03	0.04	9.6e-05	4.3e-05	1.0e-04	6.2e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.1	0.1	0.1	0.1	-0.4	-0.3	0.3
Area under the delay curve	0.5	0.5	0.8	-0.4	-0.9	-0.8	0.7
BMI with tail	1.4	4.5	5.3	1.7	2.3	2.2	-2.2
BMI without tail	7.2	14.9	19.0	2.6	4.4	4.1	-4.1
Body weight	2.9	12.3	15.6	2.2	4.0	3.8	-3.8
Weight adjusted by age	1.0	1.2	1.5	0.8	1.1	1.2	-1.2
Bone surface	0.4	0.7	1.0	-1.0	-0.9	-0.8	0.7
Bone volume	0.0	0.1	0.1	-0.2	-0.3	-0.2	0.1
Breakpoint value in progressive ratio session	0.2	0.2	0.3	0.1	-0.6	-0.4	0.4
Number of licking bursts	2.3	2.7	4.4	2.1	1.4	1.5	-1.4
Context. condit. distance diff. score	2.2	2.7	3.4	-1.4	-1.9	-1.6	1.6
Locomotion velocity, session 1	1.4	1.5	2.1	-0.7	-1.4	-1.4	1.3
Locomotion distance, session 1	0.9	1.2	1.4	-1.2	-1.0	-1.1	1.1
Locomotion velocity, session 2	0.2	0.2	0.3	-0.4	-0.5	-0.4	0.4
Locomotion distance, session 2	0.1	0.1	0.3	-0.6	-0.0	-0.2	0.2
Locomotion velocity, session 3	0.3	0.3	0.3	-0.5	-0.6	-0.6	0.5
Locomotion distance, session 3	2.1	2.2	2.9	-1.2	-1.7	-1.5	1.5
Stereotopy head waving bouts, day 3	1.3	1.5	2.4	0.8	1.5	1.3	-1.2
Stereotopy head waving duration, day 3	0.1	0.1	0.4	-0.6	-0.1	-0.3	0.3
Locomotion velocity, session 7	0.1	0.1	0.2	0.4	-0.5	-0.2	0.2
Locomotion distance, session 7	0.1	0.1	0.2	0.5	-0.2	0.1	-0.2
Stereotopy head waving bouts, day 7	1.1	1.2	2.1	-1.4	-0.8	-1.0	1.1
Stereotopy head waving duration, day 7	0.9	1.2	2.5	-1.6	-0.7	-0.9	0.9
Locomotion velocity, session 8	4.0	4.7	6.9	-1.5	-2.6	-2.3	2.2
Locomotion distance, session 8	1.3	1.9	2.1	-1.5	-1.4	-1.3	1.3
Degree of sensitization distance	2.7	2.7	3.2	1.3	1.7	1.8	-1.8
Degree of sensitization stereotypy	4.1	4.5	5.8	-2.4	-2.0	-2.0	2.0
Conditioned locomotion	0.2	0.3	0.3	-0.3	-0.5	-0.6	0.6
Cocaine response after cond. corrected	0.4	0.5	1.1	1.0	0.3	0.6	-0.6
Cocaine response after cond. not corrected	0.0	0.0	0.1	0.1	-0.2	-0.1	0.1
Cocaine response before conditioning	1.3	1.5	2.7	-1.6	-0.8	-1.2	1.2
Saline control response	0.2	0.3	0.9	-1.0	0.3	0.2	-0.2
Bone: connectivity density	0.9	1.5	1.9	-0.8	-1.4	-1.3	1.3
Bone: cortical apparent density	0.6	0.8	1.5	1.2	0.7	0.8	-0.8
Bone: cortical area	0.2	0.3	0.5	0.1	0.5	0.6	-0.7
Bone: cortical porosity	1.0	1.0	2.0	-1.4	-0.7	-0.9	1.0
Bone: cortical porosity	0.7	0.8	1.5	-1.2	-0.6	-0.8	0.8
Bone: cortical thickness	0.2	0.4	0.5	0.7	0.6	0.6	-0.6
Bone: cortical thickness	0.2	0.2	0.4	-0.3	-0.6	-0.5	0.4
Bone: cortical tissue density	0.5	0.7	1.4	1.2	0.6	0.7	-0.7
Condit. Reinf. active minus inactive responses	1.5	1.7	2.0	0.9	1.4	1.4	-1.4
Condit. Reinf. active-inactive response ratio	1.1	1.2	1.5	0.5	1.2	1.2	-1.2
Condit. Reinf. active responses	1.2	1.4	1.6	1.0	1.2	1.3	-1.3
Condit. Reinf. inactive responses	0.1	0.1	0.3	0.5	0.2	0.3	-0.3
Incentive salience index mean	0.8	1.0	1.2	0.9	0.9	1.1	-1.1
Condit. Reinf. lever presses	0.0	0.1	0.2	0.4	-0.3	-0.1	0.0
Condit. Reinf. active minus inactive responses	0.6	0.7	2.8	-1.7	-0.1	-0.1	0.1
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	-0.5	-0.4	-0.2	0.2
Condit. Reinf. active responses	0.8	1.1	4.2	-2.1	0.1	0.1	-0.1
Condit. Reinf. inactive responses	0.7	0.8	2.3	-1.5	0.8	0.5	-0.5
Condit. Reinf. lever presses	6.8	9.3	21.5	-4.6	-2.2	-2.4	2.3
Condit. Reinf. lever reinforcers received	1.0	1.4	5.4	-2.3	-0.1	-0.2	0.1
Conditioned reinforcement - actives	3.5	3.5	3.7	-1.8	-1.9	-1.9	1.8
Conditioned reinforcement - inactives	0.0	0.0	0.0	0.1	-0.2	-0.1	0.2
Conditioned locomotion	3.2	3.9	4.1	-1.9	-2.0	-2.0	2.0
Patch foraging indifference point 0 sec	1.3	2.1	6.2	-2.5	-0.7	-0.9	0.9
Patch foraging indifference point AUC	0.1	0.1	0.1	0.2	0.2	0.3	-0.3
Delay disc. indifference point, 0s delay	0.1	0.1	0.3	-0.6	-0.0	-0.0	0.0
Delay disc. indifference point, 16s delay	0.9	1.0	1.3	-0.6	-1.1	-1.1	1.0
Delay disc. indifference point, 2s delay	0.7	0.8	1.5	-1.2	-0.7	-0.8	0.7
Delay disc. indifference point, 24s delay	0.2	0.2	0.5	0.7	-0.3	-0.1	0.1
Delay disc. indifference point, 4s delay	0.0	0.1	0.2	-0.4	-0.2	-0.1	0.0
Delay disc. indifference point, 8s delay	0.8	0.9	1.2	-0.7	-1.1	-1.0	0.9
Indifference point function ln k	1.7	2.4	3.5	-1.9	-1.3	-1.5	1.5
Indifference point function log k	1.7	2.4	3.5	-1.9	-1.3	-1.5	1.5
Patch foraging total patch changes 0 sec	1.2	1.9	5.3	-2.3	-0.7	-0.9	0.9
Patch foraging total patch changes 12 sec	0.1	0.2	0.2	-0.3	0.5	0.5	-0.5
Patch foraging total patch changes 18 sec	0.1	0.1	0.5	-0.7	0.1	0.1	-0.2
Patch foraging total patch changes 24 sec	0.1	0.2	0.2	-0.2	0.4	0.4	-0.5
Patch foraging total patch changes 6 sec	0.4	0.6	1.6	-1.3	-0.4	-0.6	0.6
Patch foraging time to switch 0 sec	1.0	1.6	3.6	1.9	1.0	1.0	-0.9
Patch foraging water rate 0 sec	1.4	2.2	4.6	-2.1	-1.2	-1.2	1.2
Patch foraging water rate 12 sec	1.5	2.2	3.7	-1.9	-1.3	-1.4	1.3
Patch foraging water rate 18 sec	0.1	0.2	0.4	-0.6	-0.4	-0.3	0.3
Patch foraging water rate 24 sec	1.9	2.6	2.9	-1.4	-1.7	-1.7	1.6
Patch foraging water rate 6 sec	1.3	1.8	1.9	-1.4	-1.3	-1.4	1.3
Seeking ratio, delayed vs. immediate footshock	0.4	0.5	1.6	1.3	0.1	0.4	-0.4
Distance traveled before self-admin	0.1	0.1	0.3	0.5	0.3	0.3	-0.3
Distance traveled after self-admin	0.0	0.0	0.1	0.1	-0.0	-0.2	0.2
Extensor digitorum longus weight	0.4	1.7	2.0	1.2	1.2	1.4	-1.4
Bone: elastic displacement	0.1	0.1	0.5	0.7	-0.2	-0.1	0.1
Bone: elastic work	0.5	0.7	1.1	0.3	-1.0	-0.9	0.9
Bone: endosteal estimation	0.1	0.3	0.5	-0.1	0.5	0.6	-0.7
Bone: endosteal perimeter	0.1	0.2	0.7	-0.8	-0.3	-0.1	0.1
Epididymis fat weight	4.3	10.0	11.0	2.7	3.3	3.3	-3.3
Delta time in closed arm before/after self-admin	1.4	1.4	1.9	1.4	0.9	1.1	-1.2
Delta time in open arm before/after self-admin	0.4	0.4	1.4	-1.2	-0.3	-0.3	0.3
Diff in mean of infusions in LGA sessions	1.9	2.1	4.0	2.0	1.2	1.2	-1.2
Delay discount exponential model param	0.5	0.6	0.8	0.5	0.9	0.8	-0.8
Extinction: sum of active levers before priming	0.2	0.2	0.2	0.4	0.3	0.4	-0.4
Active lever presses in extinction session 6	3.5	3.4	6.6	-2.6	-1.3	-1.6	1.6
Bone: final force	0.1	0.2	0.3	-0.3	-0.6	-0.5	0.5
Bone: final moment	0.1	0.2	0.3	-0.4	-0.5	-0.4	0.4
Food consumed during 24 hour testing period	2.7	3.2	4.1	-2.0	-1.6	-1.7	1.7
Glucose	0.1	0.2	0.3	-0.3	-0.6	-0.4	0.4
Heart weight	0.4	0.6	1.0	-1.0	-0.7	-0.7	0.6
Delay discount hyperbolic model param	0.5	0.5	0.7	0.6	0.8	0.7	-0.7
Intermittent access intake day 1-15 change	3.1	3.0	3.5	-1.9	-1.7	-1.7	1.7
Intermittent access intake escalation	3.4	3.3	4.3	-2.1	-1.7	-1.8	1.7
Intermittent access intake escalation 2	0.4	0.3	0.8	-0.9	-0.5	-0.5	0.4
Intermitt. access day 1 inactive lever presses	0.3	0.3	0.4	0.7	0.5	0.5	-0.5
Intermitt. access day 15 inactive lever presses	0.1	0.1	0.1	-0.1	-0.3	-0.3	0.3
Intermitt. access escalation Index	0.0	0.0	0.0	-0.1	0.0	-0.1	0.1
Intermittent access day 1 total infusions	0.2	0.2	0.3	-0.5	-0.5	-0.4	0.3
Intermittent access day 15 total infusions	3.1	3.5	3.8	-1.9	-1.9	-1.8	1.8
Intermittent access terminal intake (last 3 days)	1.1	1.2	1.5	-1.2	-1.1	-1.0	1.0
Intermittent access total infusions	0.4	0.5	0.6	-0.7	-0.8	-0.6	0.6
Intermittent access day 1 locomotion	0.4	0.4	0.6	-0.3	-0.8	-0.7	0.7
Intermittent access day 15 total locomotion	1.2	1.3	2.0	-1.4	-1.0	-1.0	1.0
Intermittent access total locomotion	0.2	0.2	0.3	-0.6	-0.5	-0.4	0.4
Intermittent access standard deviation	0.0	0.0	0.0	-0.1	0.1	0.1	-0.1
Left kidney weight	0.8	2.3	3.1	0.5	1.7	1.7	-1.7
Right kidney weight	0.7	1.9	2.7	0.4	1.7	1.5	-1.5
Cocaine induced anxiety	0.9	1.0	2.1	1.5	0.8	0.8	-0.8
Post-drug Anxiety	0.1	0.1	0.3	0.5	0.3	0.3	-0.3
Baseline Anxiety	1.7	1.8	2.9	-1.7	-1.2	-1.2	1.1
Tail length	2.9	8.9	12.4	1.0	3.5	3.3	-3.3
Length with tail	2.1	7.8	10.6	1.3	3.3	3.1	-3.1
Length without tail	0.0	0.0	0.0	0.2	-0.1	-0.1	0.1
Times rat made contact with spout	1.1	1.3	1.5	1.0	1.2	1.2	-1.1
Lifetime Intake	0.7	0.8	0.9	-0.9	-0.9	-0.8	0.8
Liver weight, left	1.1	1.7	2.1	0.9	1.4	1.4	-1.4
Liver weight, right	5.9	9.7	11.7	2.5	3.4	3.3	-3.2
Locomotor activity	0.2	0.3	0.5	-0.5	0.7	0.4	-0.3
Locomotor testing distance	0.3	0.5	0.7	-0.7	0.9	0.7	-0.7
Locomotor testing rearing	2.0	3.2	4.5	0.6	2.1	2.0	-2.0
Locomotion in novel chamber	1.9	2.4	2.6	-1.4	-1.5	-1.6	1.6
Locomotion in novel chamber post-restriction	5.9	7.1	7.7	-2.8	-2.6	-2.6	2.6
Fecal boli incidents, locomotor time 1	2.1	2.3	2.7	-1.4	-1.7	-1.5	1.4
Change in fecal boli incidents, locomotor task	0.4	0.4	0.6	0.8	0.7	0.5	-0.5
Time >=10cm from walls, locomotor time 1	2.7	2.7	3.7	-1.9	-1.5	-1.6	1.6
Bouts of movement, locomotor time 1	0.2	0.2	0.3	-0.5	-0.5	-0.5	0.4
Total resting periods, locomotor time 1	0.5	0.6	0.7	-0.6	-0.9	-0.8	0.8
Rest time, locomotor task time 1	0.8	0.9	1.2	-0.5	-1.1	-1.0	1.0
Distance moved, locomotor task time 1	1.1	1.2	1.5	0.6	1.2	1.2	-1.2
Vertical activity count, locomotor time 1	0.4	0.5	0.6	0.3	0.8	0.8	-0.8
Time >=10cm from walls, locomotor time 2	0.2	0.3	0.7	-0.8	-0.3	-0.3	0.3
Bouts of movement, locomotor time 2	0.1	0.1	0.5	-0.7	0.2	0.0	-0.0
Total resting periods, locomotor time 2	0.1	0.1	0.3	-0.6	0.1	-0.0	0.0
Rest time, locomotor task time 2	0.2	0.2	0.8	0.9	0.2	0.2	-0.1
Distance moved, locomotor task time 2	0.2	0.2	0.6	-0.8	0.2	0.3	-0.3
Vertical activity count, locomotor time 2	0.4	0.4	0.7	0.2	0.7	0.8	-0.8
Light reinforcement 1	1.3	2.3	2.7	1.7	1.5	1.4	-1.4
Light reinforcement 2	0.1	0.1	0.3	-0.5	-0.0	-0.2	0.2
Bone: marrow area	0.1	0.3	0.5	-0.0	0.5	0.6	-0.7
Bone: maximum diameter	0.1	0.3	1.0	-1.0	-0.2	-0.1	0.0
Bone: maximum force	0.4	0.7	1.0	-0.6	-1.0	-0.9	0.9
Bone: maximum moment	0.4	0.7	0.9	-0.7	-1.0	-0.9	0.8
Mean time between licks in bursts	0.4	0.6	0.9	-0.9	0.7	0.7	-0.7
Mean num. licks in bursts	1.3	1.5	2.8	-1.7	-1.1	-1.1	1.0
Cd content in liver	1.3	1.4	2.1	1.4	1.0	1.1	-1.1
Co content in liver	0.2	0.2	0.3	0.3	0.3	0.5	-0.6
Cu content in liver	0.8	0.9	1.3	0.4	1.1	1.1	-1.1
Fe content in liver	0.0	0.0	0.0	0.1	-0.2	-0.0	-0.0
K content in liver	0.5	0.5	0.6	0.7	0.8	0.7	-0.6
Mg content in liver	0.0	0.0	0.1	-0.3	0.0	-0.0	0.0
Mn content in liver	0.2	0.2	0.3	0.4	-0.5	-0.5	0.5
Na content in liver	1.0	1.0	1.7	-1.3	-0.7	-1.0	1.0
Rb content in liver	0.0	0.0	0.1	-0.1	0.1	0.2	-0.3
Se content in liver	0.6	0.7	2.3	1.5	0.4	0.5	-0.4
Sr content in liver	0.4	0.4	0.7	-0.2	-0.8	-0.7	0.6
Zn content in liver	0.6	0.7	2.5	-1.6	-0.2	-0.3	0.3
Bone: minimum diameter	1.0	1.9	2.5	0.9	1.4	1.5	-1.6
Time in familiar zone, hab. session 1	0.0	0.0	0.1	0.3	-0.1	0.0	-0.0
Time in novel zone, hab. session 1	0.6	0.6	0.8	0.5	0.9	0.8	-0.8
Total zone transitions, hab. session 1	0.7	1.0	1.2	-1.1	-0.8	-1.0	1.1
Total locomotion distance, hab. session 1	4.9	6.9	9.2	2.0	3.0	2.7	-2.6
Locomotion velocity, hab. session 1	3.8	5.4	7.4	1.7	2.7	2.4	-2.3
Time in familiar zone, hab. session 2	0.0	0.0	0.0	-0.1	0.0	0.1	-0.2
Time in novel zone, hab. session 2	0.1	0.1	0.1	-0.3	-0.2	-0.2	0.2
Total zone transitions, hab. session 2	1.3	1.7	3.1	-1.8	-0.9	-1.2	1.2
Total locomotion distance, hab. session 2	3.3	4.4	6.3	1.3	2.5	2.2	-2.2
Locomotion velocity, hab. session 2	3.8	5.1	7.2	1.4	2.7	2.4	-2.3
Novel to familiar place preference ratio	0.1	0.1	0.5	-0.7	-0.1	-0.2	0.3
Novelty place preference	0.1	0.1	0.2	-0.5	-0.1	-0.2	0.2
Time in novel zone, NPP test	0.2	0.2	0.4	-0.6	-0.3	-0.3	0.3
Total zone transitions, NPP test	1.0	1.4	1.6	-1.0	-1.2	-1.3	1.3
Total locomotion distance, NPP test	3.0	4.1	4.9	1.7	2.2	2.1	-2.1
Locomotion velocity, NPP test	3.5	5.0	6.0	1.9	2.4	2.3	-2.3
Intraocular pressure	2.6	3.6	5.7	-1.1	-2.4	-2.0	1.9
Delta distance traveled before/after self-admin	0.2	0.2	0.5	-0.7	-0.2	-0.4	0.5
Delta ambulatory time before/after self-admin	0.7	0.8	0.9	-0.9	-0.7	-0.9	1.0
Parametrial fat weight	1.5	3.0	4.1	1.2	2.0	1.8	-1.8
Pavlov. Cond. lever latency	0.1	0.1	0.2	0.5	0.4	0.3	-0.3
Pavlov. Cond. magazine entry latency	0.2	0.2	0.9	-0.9	-0.0	-0.0	0.0
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	-0.5	-0.4	-0.2	0.2
Pavlov. Cond. index score	0.1	0.1	0.3	-0.6	-0.0	0.1	-0.1
Pavlov. Cond. latency score	0.1	0.1	0.4	-0.6	-0.1	0.0	-0.1
Pavlov. Cond. lever contacts	0.0	0.0	0.0	0.0	-0.0	0.2	-0.2
Pavlov. Cond. magazine entry number	0.3	0.3	1.1	1.1	0.3	0.2	-0.2
Pavlov. Cond. intertrial magazine entries	0.8	1.0	1.8	1.3	0.8	0.9	-0.8
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.3	-0.5	-0.1	-0.0	-0.0
Pavlov. Cond. response bias	0.1	0.1	0.1	0.0	0.2	0.3	-0.3
Pavlov. Cond. lever latency	8.6	11.5	23.6	4.9	2.7	2.8	-2.7
Pavlov. Cond. magazine entry latency	5.1	5.9	7.7	-2.8	-2.4	-2.3	2.2
Pavlov. Cond. change in total contacts	5.5	7.6	16.6	-4.1	-2.1	-2.2	2.1
Pavlov. Cond. index score	7.6	9.7	18.3	-4.3	-2.6	-2.7	2.6
Pavlov. Cond. latency score	7.8	9.6	17.3	-4.2	-2.7	-2.7	2.6
Pavlov. Cond. lever contacts	8.1	11.1	24.2	-4.9	-2.5	-2.7	2.6
Pavlov. Cond. magazine entry number	6.2	7.6	9.0	3.0	2.9	2.6	-2.5
Pavlov. Cond. intertrial magazine entries	3.2	4.1	5.7	1.2	2.4	2.2	-2.2
Pavlov. Cond. lever-magazine prob. diff.	6.8	8.7	16.9	-4.1	-2.4	-2.5	2.4
Pavlov. Cond. response bias	8.7	11.8	23.9	-4.9	-2.8	-2.9	2.7
Time in closed arm before self-admin	2.4	2.7	3.2	-1.8	-1.5	-1.6	1.7
Time in closed arm after self-admin	1.7	1.7	2.5	-0.4	-1.6	-1.4	1.4
Time in open arm before self-admin	1.9	2.1	3.7	1.9	1.2	1.3	-1.3
Time in open arm after self-admin	1.1	1.2	1.6	0.5	1.3	1.2	-1.2
Bone: periosteal estimation	0.1	0.2	0.3	-0.2	0.3	0.5	-0.6
Bone: periosteal perimeter	0.1	0.1	0.3	-0.5	0.1	0.2	-0.2
Bone: post-yield work	0.3	0.4	0.6	-0.8	-0.6	-0.7	0.7
Progressive ratio test 1 active lever presses	0.0	0.0	0.0	0.2	-0.2	-0.2	0.2
Progressive ratio test 1 breakpoint	0.0	0.0	0.0	0.2	-0.2	-0.1	0.1
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.0	-0.1	-0.1	-0.1	0.0
Progressive ratio test 2 active lever presses	0.2	0.2	0.5	-0.7	-0.4	-0.2	0.2
Progressive ratio test 2 breakpoint	0.1	0.1	0.3	-0.6	-0.2	-0.1	0.0
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.2	-0.4	-0.4	-0.3	0.2
Incentive Sensitization - Responses	0.2	0.2	0.9	-0.9	-0.2	-0.1	0.1
Incentive Sensitization - Breakpoint	0.3	0.3	1.0	-1.0	-0.3	-0.2	0.2
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.3	0.0	0.5	0.4	-0.4
Progressive ratio	1.0	1.2	1.9	-0.5	-1.4	-1.2	1.2
Food seeking constrained by brief footshock	0.3	0.4	1.1	-1.1	0.6	0.4	-0.4
Seeking ratio, punishment vs. effort	1.5	1.9	3.2	-0.2	1.8	1.5	-1.4
Retroperitoneal fat weight	10.7	35.3	37.0	5.6	6.0	6.1	-6.1
Reaction time number correct	0.5	0.8	1.0	-1.0	-0.6	-0.9	1.0
Reaction time mean minus median	0.1	0.2	0.4	-0.6	0.4	0.3	-0.3
Reaction time mean minus median AUC	0.3	0.4	1.4	-1.2	-0.1	-0.3	0.3
Reaction time num false alarms	2.0	2.7	4.9	2.2	1.3	1.4	-1.4
Reaction time num false alarms AUC	0.7	1.0	2.6	1.6	0.5	0.7	-0.8
Reaction time trials correct on left	0.5	0.8	1.0	-1.0	-0.6	-0.9	1.0
Reaction time trials on left	0.6	0.8	1.1	-1.0	-0.6	-0.9	1.0
Reaction time mean	0.3	0.4	0.5	0.4	0.7	0.6	-0.6
Reaction time mean AUC	0.2	0.2	0.2	0.5	0.5	0.5	-0.4
Median of all reaction times	0.1	0.2	0.2	0.5	0.4	0.4	-0.4
Reaction time omissions	0.1	0.1	0.2	0.1	0.4	0.4	-0.4
Reaction time false alarm rate	1.2	1.7	3.7	1.9	0.7	1.1	-1.1
Reaction time premature initiation rate	2.3	3.0	4.3	0.5	2.1	1.9	-2.0
Reaction time premature initiations	0.8	1.1	1.9	-0.2	1.4	1.1	-1.1
Std. dev. reaction times	0.5	0.7	1.0	0.1	1.0	0.9	-0.9
Reaction time trials completed	0.6	0.8	1.1	-1.0	-0.6	-0.9	1.0
Reaction time trials AUC	0.4	0.6	0.9	-0.9	-0.4	-0.7	0.8
Run reversals in cocaine runway, females	5.1	5.0	5.6	2.1	2.1	2.3	-2.4
Run reversals in cocaine runway, males	1.3	1.2	2.0	-0.5	-1.4	-1.2	1.2
Latency to leave start box in cocaine runway	0.9	1.0	1.3	1.1	1.0	0.9	-0.9
Latency to leave start box in cocaine runway, F	1.5	1.6	1.7	1.3	1.2	1.3	-1.3
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	-0.2	-0.3	-0.4	0.5
Std. dev. time between licks in bursts	1.4	1.7	2.6	0.3	1.6	1.5	-1.4
Total sessions with >9 infusions	1.5	1.7	2.5	-1.6	-1.1	-1.2	1.2
Short access day 1 total inactive lever presses	0.1	0.1	0.2	-0.1	-0.5	-0.3	0.3
Short access day 10 total inactive lever presses	0.2	0.2	0.4	0.2	0.7	0.5	-0.4
Short access day 1 total infusions	0.8	0.9	2.0	-1.4	-0.7	-0.7	0.7
Short access day 10 total infusions	0.1	0.1	0.2	-0.3	-0.4	-0.3	0.2
Short access total infusions	0.1	0.2	0.3	-0.5	-0.4	-0.3	0.3
Short access day 1 locomotion	4.3	4.6	5.0	-2.2	-2.1	-2.1	2.1
Short access day 10 total locomotion	0.0	0.0	0.1	-0.2	-0.1	-0.1	0.1
Short access total locomotion	0.2	0.2	0.3	-0.5	-0.3	-0.4	0.4
One hour access (0.3 mA shock)	0.3	0.3	0.9	-1.0	-0.4	-0.3	0.3
Compulsive drug intake	0.0	0.0	0.0	-0.2	0.0	-0.0	0.1
One hour access (shock baseline)	0.5	0.6	1.3	-1.1	-0.7	-0.6	0.6
Social response proportion	1.1	1.2	1.7	0.8	1.3	1.1	-1.0
Social responses	2.7	3.4	4.0	1.6	2.0	1.9	-1.9
Social time	0.8	1.0	1.7	1.3	0.9	0.9	-0.8
Soleus weight	1.7	5.0	5.6	1.9	2.3	2.4	-2.4
Bone: stiffness	0.0	0.0	0.1	0.0	-0.2	-0.2	0.2
Tibialis anterior weight	0.1	0.4	0.7	-0.0	0.9	0.7	-0.7
Time to tail flick, vehicle, before self-admin	0.9	0.9	1.2	1.1	0.9	0.9	-0.9
Time to tail flick, vehicle, after self-admin	1.9	2.0	2.4	-1.6	-1.4	-1.4	1.3
Time to tail flick, test, before self-admin	0.0	0.0	0.1	0.3	-0.2	-0.0	-0.0
Time to tail flick, test, after self-admin	0.1	0.1	0.1	0.1	0.1	0.3	-0.3
Delta time to tail flick, vehicle, before/after SA	4.8	4.8	5.4	-2.3	-2.1	-2.1	2.1
Delta time to tail flick, test, before/after SA	0.0	0.0	0.0	-0.2	0.1	-0.0	0.0
Tibia length	1.1	3.1	4.4	-2.1	-1.6	-1.7	1.6
Ambulatory time before self-admin	0.1	0.1	0.1	0.3	-0.3	-0.2	0.2
Ambulatory time after self-admin	0.4	0.5	0.7	-0.3	-0.7	-0.8	0.8
Bone: tissue strength	0.8	0.8	1.2	-0.6	-0.8	-1.0	1.1
Total heroin consumption	0.1	0.1	0.1	-0.3	-0.3	-0.3	0.3
Bone: trabecular number	0.2	0.2	0.5	0.7	-0.5	-0.3	0.3
Bone: trabecular spacing	0.7	0.9	2.1	-1.5	-0.6	-0.7	0.7
Bone: trabecular thickness	0.6	0.8	1.1	1.0	0.7	0.8	-0.9
Bone: trabecular tissue density	2.3	3.3	4.2	1.4	2.1	1.9	-1.8
Water consumed over 24 hours	0.4	0.5	1.0	1.0	0.5	0.5	-0.5
Number of responses in last shaping day	1.5	1.6	1.8	0.9	1.3	1.4	-1.4