Hub : Genes

LOC102550562

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	LOC102550562	0.14	0.07	4.8e-13	0.08	0.09	0.08	0.08	7.4e-09	9.8e-10	3.4e-09	6.8e-09
2	pVTA	gene expression	LOC102550562	0.04	0.03	5.3e-03	0	0.01	0	0	2.3e-01	3.3e-02	1.8e-01	2.2e-01
3	Adipose	alternative TSS	XR_005499320.2	0.02	0.02	8.7e-03	0	0	0	-0	2.6e-01	3.2e-01	3.3e-01	3.9e-01
4	Adipose	alternative TSS	XR_005499321.2	0.03	0.02	5.9e-03	0	0	0	0	7.5e-02	2.6e-01	2.7e-01	2.9e-01
5	NAcc	gene expression	LOC102550562	0.02	0.01	2.6e-03	0	0.01	0.01	0.01	8.3e-02	3.8e-02	2.7e-02	3.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	0.2	0.3	0.5	-0.2	-0.4	-0.6	0.6	-0.7
Area under the delay curve	0.3	0.4	0.8	-0.9	-0.9	-0.2	0.2	-0.1
BMI with tail	3.0	10.3	13.0	3.6	3.6	3.0	-3.0	2.8
BMI without tail	4.8	14.5	17.6	4.0	4.2	3.7	-3.7	3.4
Body weight	3.9	17.1	22.9	4.5	4.8	3.9	-4.0	3.3
Weight adjusted by age	0.9	1.4	2.0	0.9	1.0	1.4	-1.4	1.0
Bone surface	0.2	0.3	0.5	-0.7	-0.5	0.5	-0.5	0.3
Bone volume	0.1	0.3	0.5	-0.1	-0.0	0.7	-0.7	0.5
Breakpoint value in progressive ratio session	0.7	0.8	1.2	-0.5	-0.8	-1.1	1.1	-1.0
Number of licking bursts	0.4	0.6	2.0	1.4	0.9	-0.1	0.1	-0.1
Context. condit. distance diff. score	1.0	1.2	3.1	-1.8	-1.6	-0.2	0.2	-0.6
Locomotion velocity, session 1	1.5	1.7	2.4	-1.4	-1.5	-1.2	1.2	-1.1
Locomotion distance, session 1	0.3	0.4	0.9	-1.0	-0.7	-0.5	0.5	0.0
Locomotion velocity, session 2	0.1	0.1	0.2	-0.4	-0.3	0.2	-0.2	0.3
Locomotion distance, session 2	0.0	0.0	0.1	0.0	0.3	0.2	-0.2	0.3
Locomotion velocity, session 3	0.1	0.1	0.3	-0.5	-0.5	-0.0	0.0	-0.1
Locomotion distance, session 3	1.3	1.4	3.0	-1.7	-1.6	-0.7	0.7	-0.7
Stereotopy head waving bouts, day 3	0.8	1.0	2.4	1.5	1.5	0.3	-0.3	0.1
Stereotopy head waving duration, day 3	0.0	0.0	0.1	0.1	0.2	-0.2	0.2	-0.2
Locomotion velocity, session 7	0.3	0.3	0.6	-0.5	-0.7	-0.2	0.2	-0.7
Locomotion distance, session 7	0.1	0.1	0.2	-0.2	-0.4	0.5	-0.5	0.1
Stereotopy head waving bouts, day 7	0.7	0.8	1.3	-1.1	-0.8	-0.8	0.8	-1.0
Stereotopy head waving duration, day 7	0.1	0.1	0.5	-0.7	-0.3	-0.1	0.1	-0.2
Locomotion velocity, session 8	2.4	2.9	6.4	-2.5	-2.5	-0.5	0.5	-1.1
Locomotion distance, session 8	0.4	0.6	1.7	-1.3	-1.0	0.0	-0.0	-0.3
Degree of sensitization distance	2.5	2.6	2.9	1.7	1.7	1.6	-1.6	1.4
Degree of sensitization stereotypy	1.5	1.6	3.7	-1.9	-1.4	-0.8	0.8	-0.9
Conditioned locomotion	0.3	0.4	0.6	-0.5	-0.6	-0.6	0.8	-0.5
Cocaine response after cond. corrected	0.1	0.1	0.4	0.2	-0.0	0.4	-0.3	0.6
Cocaine response after cond. not corrected	0.1	0.1	0.2	-0.4	-0.4	-0.1	0.2	-0.0
Cocaine response before conditioning	0.9	1.1	1.6	-0.9	-0.6	-1.2	1.2	-1.3
Saline control response	0.5	0.7	1.2	0.2	0.7	0.9	-0.9	1.1
Bone: connectivity density	0.8	1.3	1.7	-1.2	-1.3	-1.1	1.1	-1.0
Bone: cortical apparent density	0.0	0.1	0.2	0.4	0.1	-0.2	0.2	-0.2
Bone: cortical area	0.8	1.2	1.9	0.8	0.9	1.4	-1.4	1.0
Bone: cortical porosity	0.3	0.4	0.5	-0.6	-0.4	-0.6	0.6	-0.7
Bone: cortical porosity	0.4	0.4	0.5	-0.6	-0.3	-0.7	0.7	-0.7
Bone: cortical thickness	0.1	0.1	0.4	0.6	0.4	0.2	-0.2	0.1
Bone: cortical thickness	0.1	0.2	0.4	-0.2	-0.2	0.4	-0.4	0.6
Bone: cortical tissue density	0.1	0.1	0.1	0.3	-0.0	-0.3	0.3	-0.3
Condit. Reinf. active minus inactive responses	1.8	2.0	2.8	1.3	1.3	1.4	-1.3	1.7
Condit. Reinf. active-inactive response ratio	1.7	1.8	2.4	1.2	1.3	1.3	-1.3	1.5
Condit. Reinf. active responses	0.9	1.2	1.5	1.2	1.1	0.9	-0.9	1.2
Condit. Reinf. inactive responses	0.0	0.0	0.0	0.2	0.1	-0.1	0.1	0.0
Incentive salience index mean	1.1	1.3	2.2	0.9	0.9	1.2	-1.2	1.5
Condit. Reinf. lever presses	0.1	0.1	0.2	-0.3	-0.3	0.2	-0.2	0.5
Condit. Reinf. active minus inactive responses	2.1	2.7	4.6	0.0	0.8	2.0	-2.1	2.0
Condit. Reinf. active-inactive response ratio	0.7	0.8	1.4	-0.2	0.0	1.0	-1.1	1.2
Condit. Reinf. active responses	3.4	4.7	7.6	0.3	1.3	2.7	-2.8	2.7
Condit. Reinf. inactive responses	2.1	2.8	3.7	0.7	1.6	1.9	-1.9	1.8
Condit. Reinf. lever presses	1.8	2.5	3.4	-1.8	-0.4	1.8	-1.7	1.6
Condit. Reinf. lever reinforcers received	3.3	4.6	7.5	0.1	1.2	2.7	-2.7	2.7
Conditioned reinforcement - actives	0.4	0.6	1.5	-1.2	-1.0	-0.3	0.3	-0.7
Conditioned reinforcement - inactives	0.9	1.3	1.8	-0.8	-0.9	-1.3	1.3	-1.3
Conditioned locomotion	2.0	2.6	5.1	-2.3	-1.9	-0.9	0.9	-1.5
Patch foraging indifference point 0 sec	0.3	0.5	0.9	-0.6	0.2	0.8	-0.8	1.0
Patch foraging indifference point AUC	0.3	0.4	0.8	0.3	0.3	0.7	-0.7	0.9
Delay disc. indifference point, 0s delay	0.4	0.5	1.0	-0.0	0.3	0.8	-0.8	1.0
Delay disc. indifference point, 16s delay	0.8	0.9	1.5	-1.1	-1.2	-0.8	0.8	-0.6
Delay disc. indifference point, 2s delay	0.1	0.2	0.5	-0.7	-0.4	0.2	-0.2	0.2
Delay disc. indifference point, 24s delay	0.2	0.2	0.3	-0.2	-0.6	-0.4	0.4	-0.5
Delay disc. indifference point, 4s delay	0.8	0.8	1.4	-0.1	0.1	1.2	-1.2	1.1
Delay disc. indifference point, 8s delay	0.4	0.4	1.0	-1.0	-1.0	-0.3	0.3	-0.2
Indifference point function ln k	0.6	1.1	1.6	-1.3	-1.0	-0.8	0.8	-1.2
Indifference point function log k	0.6	1.1	1.6	-1.3	-1.0	-0.8	0.8	-1.2
Patch foraging total patch changes 0 sec	0.2	0.5	0.8	-0.7	0.1	0.7	-0.7	0.9
Patch foraging total patch changes 12 sec	1.0	1.3	2.0	0.6	1.0	1.4	-1.4	1.2
Patch foraging total patch changes 18 sec	1.1	1.8	3.0	0.3	0.8	1.6	-1.6	1.7
Patch foraging total patch changes 24 sec	0.8	1.4	2.9	0.6	0.9	1.2	-1.2	1.7
Patch foraging total patch changes 6 sec	0.0	0.0	0.2	-0.4	-0.1	0.0	-0.0	-0.0
Patch foraging time to switch 0 sec	0.5	1.1	1.8	0.8	0.2	-1.2	1.3	-1.3
Patch foraging water rate 0 sec	0.4	0.7	1.1	-1.0	-0.4	0.9	-0.9	1.0
Patch foraging water rate 12 sec	0.2	0.4	1.3	-1.2	-0.7	0.2	-0.1	0.3
Patch foraging water rate 18 sec	0.2	0.4	0.9	-0.3	-0.1	0.7	-0.6	1.0
Patch foraging water rate 24 sec	0.9	1.2	2.6	-1.6	-1.5	-0.7	0.6	-0.6
Patch foraging water rate 6 sec	0.4	0.6	1.4	-1.2	-1.0	-0.5	0.6	-0.3
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.2	0.2	-0.3	-0.4	0.4	-0.3
Distance traveled before self-admin	0.1	0.1	0.1	0.3	0.1	-0.4	0.4	0.1
Distance traveled after self-admin	1.2	1.4	2.7	-0.2	-0.4	-1.7	1.7	-1.2
Extensor digitorum longus weight	0.6	2.5	3.1	1.5	1.4	1.7	-1.8	1.5
Bone: elastic displacement	0.5	0.6	1.0	-0.3	-0.7	-1.0	1.0	-0.8
Bone: elastic work	1.7	2.2	3.0	-1.0	-1.5	-1.7	1.7	-1.5
Bone: endosteal estimation	1.2	2.7	4.3	0.7	1.1	2.1	-2.1	1.8
Bone: endosteal perimeter	1.0	2.1	3.9	0.1	0.5	2.0	-2.0	1.5
Epididymis fat weight	0.9	3.0	5.4	2.3	2.1	1.4	-1.4	0.9
Delta time in closed arm before/after self-admin	0.5	0.4	1.1	0.6	0.2	0.6	-0.6	1.0
Delta time in open arm before/after self-admin	0.6	0.6	1.2	-0.2	0.3	1.1	-1.1	0.7
Diff in mean of infusions in LGA sessions	0.8	1.0	2.0	0.7	0.1	-1.1	1.1	-1.4
Delay discount exponential model param	0.3	0.4	0.9	0.9	0.9	0.3	-0.3	0.1
Extinction: sum of active levers before priming	0.4	0.5	0.7	0.4	0.5	0.8	-0.8	0.8
Active lever presses in extinction session 6	2.2	2.2	3.0	-1.6	-1.2	-1.7	1.7	-1.0
Bone: final force	0.2	0.3	0.4	-0.6	-0.7	-0.3	0.3	-0.6
Bone: final moment	0.1	0.2	0.3	-0.5	-0.5	-0.2	0.2	-0.5
Food consumed during 24 hour testing period	0.7	1.0	2.4	-1.6	-1.1	-0.5	0.5	-0.9
Glucose	0.2	0.3	0.7	0.2	0.1	0.8	-0.9	0.3
Heart weight	0.0	0.1	0.1	-0.2	-0.0	0.3	-0.3	0.2
Delay discount hyperbolic model param	0.2	0.2	0.6	0.8	0.7	-0.0	0.0	-0.2
Intermittent access intake day 1-15 change	0.5	1.1	2.5	-1.6	-1.2	-0.7	0.7	-0.8
Intermittent access intake escalation	0.7	1.4	3.2	-1.8	-1.4	-0.8	0.8	-0.8
Intermittent access intake escalation 2	0.3	0.4	1.0	-1.0	-0.7	-0.4	0.4	-0.3
Intermitt. access day 1 inactive lever presses	0.2	0.9	1.5	-0.1	-0.5	-1.2	1.2	-1.0
Intermitt. access day 15 inactive lever presses	0.4	0.9	1.4	0.2	-0.2	-1.2	1.2	-1.2
Intermitt. access escalation Index	0.5	0.6	0.9	-0.7	-0.9	-0.8	0.8	-0.9
Intermittent access day 1 total infusions	0.2	0.3	0.9	-0.9	-0.8	-0.2	0.2	-0.2
Intermittent access day 15 total infusions	1.3	1.9	4.5	-2.1	-1.8	-0.8	0.8	-0.9
Intermittent access terminal intake (last 3 days)	0.5	0.7	2.0	-1.4	-1.0	-0.3	0.3	-0.5
Intermittent access total infusions	0.3	0.3	0.9	-1.0	-0.7	0.1	-0.1	-0.2
Intermittent access day 1 locomotion	0.7	0.9	1.3	-1.1	-1.1	-0.7	0.7	-1.1
Intermittent access day 15 total locomotion	0.5	1.0	1.9	-1.4	-1.0	-0.7	0.7	-1.0
Intermittent access total locomotion	0.3	0.3	0.7	-0.8	-0.6	-0.1	0.1	-0.8
Intermittent access standard deviation	0.5	1.0	1.3	0.8	1.0	1.1	-1.1	1.0
Left kidney weight	1.6	7.7	10.0	2.8	3.2	2.8	-2.8	2.2
Right kidney weight	1.9	8.6	11.1	2.9	3.3	3.0	-2.9	2.5
Cocaine induced anxiety	0.3	0.4	1.2	1.1	0.7	-0.1	0.1	-0.5
Post-drug Anxiety	0.1	0.1	0.4	0.6	0.2	-0.3	0.3	-0.4
Baseline Anxiety	0.2	0.2	0.6	-0.8	-0.7	-0.0	0.0	0.3
Tail length	2.9	11.4	12.7	3.1	3.5	3.6	-3.6	3.0
Length with tail	2.4	10.5	14.1	3.4	3.8	3.2	-3.2	2.6
Length without tail	0.3	0.9	2.1	1.4	1.5	0.3	-0.4	0.0
Times rat made contact with spout	0.6	0.7	1.5	1.2	1.1	0.6	-0.6	0.3
Lifetime Intake	0.4	0.5	1.6	-1.3	-1.0	-0.1	0.1	-0.3
Liver weight, left	1.4	2.4	2.9	1.6	1.7	1.6	-1.6	1.2
Liver weight, right	4.4	7.7	11.0	3.3	3.3	2.4	-2.5	2.1
Locomotor activity	0.4	0.6	1.1	0.7	1.0	0.7	-0.6	0.8
Locomotor testing distance	1.9	3.5	4.6	1.3	1.8	2.1	-1.9	2.1
Locomotor testing rearing	2.6	5.2	6.5	2.2	2.6	2.2	-2.1	2.3
Locomotion in novel chamber	1.2	1.6	2.8	-1.7	-1.5	-0.5	0.5	-1.5
Locomotion in novel chamber post-restriction	1.4	2.2	5.4	-2.3	-1.9	-0.7	0.7	-1.1
Fecal boli incidents, locomotor time 1	0.8	1.2	2.8	-1.7	-1.5	-0.6	0.6	0.2
Change in fecal boli incidents, locomotor task	0.3	0.3	0.6	0.6	0.4	-0.4	0.4	-0.8
Time >=10cm from walls, locomotor time 1	1.1	1.2	2.7	-1.6	-1.4	-0.7	0.7	-0.7
Bouts of movement, locomotor time 1	0.1	0.1	0.2	-0.4	-0.4	0.2	-0.3	0.2
Total resting periods, locomotor time 1	0.3	0.3	0.7	-0.8	-0.8	-0.4	0.3	-0.4
Rest time, locomotor task time 1	0.9	1.1	1.9	-1.2	-1.4	-0.9	0.8	-0.8
Distance moved, locomotor task time 1	1.3	2.0	2.3	1.2	1.4	1.5	-1.5	1.4
Vertical activity count, locomotor time 1	0.6	1.3	2.0	0.8	1.0	1.2	-1.2	1.4
Time >=10cm from walls, locomotor time 2	0.3	0.5	1.0	-0.2	0.0	0.7	-1.0	0.8
Bouts of movement, locomotor time 2	0.2	0.3	0.6	0.2	0.6	0.7	-0.8	0.5
Total resting periods, locomotor time 2	0.1	0.1	0.3	0.1	0.3	0.5	-0.5	0.4
Rest time, locomotor task time 2	0.5	0.6	1.2	0.1	-0.3	-0.8	1.0	-1.1
Distance moved, locomotor task time 2	1.4	1.6	3.0	0.3	0.7	1.5	-1.7	1.5
Vertical activity count, locomotor time 2	1.4	1.9	3.0	0.6	0.9	1.5	-1.7	1.7
Light reinforcement 1	0.3	0.6	1.8	1.4	1.1	0.2	-0.2	0.3
Light reinforcement 2	0.0	0.1	0.1	-0.1	0.1	-0.4	0.3	-0.3
Bone: marrow area	1.2	2.5	4.0	0.8	1.1	2.0	-2.0	1.7
Bone: maximum diameter	0.9	1.6	2.9	0.3	0.7	1.7	-1.7	1.2
Bone: maximum force	0.4	0.7	1.1	-1.0	-1.1	-0.5	0.5	-0.8
Bone: maximum moment	0.3	0.5	0.8	-0.9	-0.9	-0.4	0.4	-0.7
Mean time between licks in bursts	1.5	3.8	5.4	0.9	1.6	2.3	-2.3	2.1
Mean num. licks in bursts	0.2	0.3	1.0	-1.0	-0.5	0.4	-0.4	0.2
Cd content in liver	1.0	1.1	1.3	1.2	1.0	1.0	-1.0	1.1
Co content in liver	0.9	1.0	1.9	0.4	0.6	1.2	-1.1	1.4
Cu content in liver	3.4	4.1	4.8	1.9	2.0	2.0	-2.0	2.2
Fe content in liver	0.0	0.0	0.0	-0.1	-0.1	0.1	-0.1	-0.0
K content in liver	0.1	0.1	0.2	0.4	0.4	-0.1	0.1	-0.2
Mg content in liver	0.0	0.0	0.0	-0.1	0.0	-0.1	0.1	-0.1
Mn content in liver	1.5	1.7	2.4	-0.7	-1.0	-1.5	1.5	-1.5
Na content in liver	0.4	0.4	0.5	-0.7	-0.3	-0.7	0.7	-0.6
Rb content in liver	0.2	0.2	0.3	0.4	0.4	0.5	-0.6	0.2
Se content in liver	1.1	1.3	2.5	0.3	-0.3	-1.6	1.5	-1.2
Sr content in liver	0.3	0.3	0.5	-0.7	-0.7	-0.4	0.4	-0.2
Zn content in liver	2.7	3.0	4.8	1.0	1.4	1.9	-1.9	2.2
Bone: minimum diameter	2.2	3.9	4.9	1.6	1.7	2.2	-2.2	2.1
Time in familiar zone, hab. session 1	0.0	0.0	0.0	-0.1	-0.2	0.1	-0.1	-0.1
Time in novel zone, hab. session 1	0.6	0.6	0.7	0.9	0.9	0.6	-0.6	0.8
Total zone transitions, hab. session 1	0.9	1.2	1.7	-0.8	-0.7	-1.3	1.3	-1.3
Total locomotion distance, hab. session 1	3.0	4.3	8.8	3.0	2.9	1.2	-1.2	1.0
Locomotion velocity, hab. session 1	2.4	3.4	7.1	2.7	2.6	1.1	-1.1	0.9
Time in familiar zone, hab. session 2	0.4	0.4	0.9	0.1	0.3	0.9	-0.9	0.6
Time in novel zone, hab. session 2	0.1	0.1	0.1	-0.3	-0.2	-0.3	0.3	0.0
Total zone transitions, hab. session 2	0.5	0.7	0.8	-0.9	-0.6	-0.9	0.9	-0.7
Total locomotion distance, hab. session 2	2.8	3.7	6.6	2.5	2.6	1.3	-1.3	1.4
Locomotion velocity, hab. session 2	3.1	4.2	7.5	2.6	2.7	1.4	-1.4	1.6
Novel to familiar place preference ratio	0.0	0.0	0.1	-0.1	0.1	-0.2	0.2	-0.3
Novelty place preference	0.0	0.0	0.0	-0.1	0.1	-0.0	0.0	-0.2
Time in novel zone, NPP test	0.0	0.0	0.1	-0.2	-0.1	-0.0	0.0	-0.2
Total zone transitions, NPP test	0.8	1.2	1.6	-1.2	-1.3	-1.1	1.1	-0.8
Total locomotion distance, NPP test	1.9	2.6	4.6	2.1	2.0	1.1	-1.1	1.3
Locomotion velocity, NPP test	2.1	2.9	5.6	2.4	2.2	1.1	-1.1	1.3
Intraocular pressure	1.9	2.7	6.1	-2.4	-2.5	-0.8	0.8	-0.9
Delta distance traveled before/after self-admin	0.6	0.6	1.0	-0.6	-0.3	-1.0	1.0	-0.8
Delta ambulatory time before/after self-admin	0.7	0.9	1.2	-0.8	-0.6	-1.1	1.1	-1.0
Parametrial fat weight	0.3	0.7	1.7	1.3	1.2	0.3	-0.3	0.1
Pavlov. Cond. lever latency	0.1	0.2	0.3	0.4	0.2	-0.4	0.4	-0.6
Pavlov. Cond. magazine entry latency	0.6	0.8	1.3	-0.0	0.4	1.2	-1.1	1.1
Pavlov. Cond. change in total contacts	0.2	0.2	0.4	-0.4	-0.2	0.4	-0.4	0.6
Pavlov. Cond. index score	0.7	0.9	1.6	0.0	0.4	1.2	-1.2	1.3
Pavlov. Cond. latency score	0.5	0.7	1.1	-0.0	0.3	1.0	-1.0	1.0
Pavlov. Cond. lever contacts	0.3	0.3	0.7	-0.0	0.1	0.7	-0.7	0.8
Pavlov. Cond. magazine entry number	0.8	1.0	1.8	-0.0	-0.5	-1.3	1.3	-1.3
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.5	0.7	0.4	-0.3	0.3	0.0
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	1.1	-0.1	0.2	1.0	-1.0	1.0
Pavlov. Cond. response bias	0.4	0.5	1.0	0.1	0.3	0.8	-0.8	1.0
Pavlov. Cond. lever latency	1.9	2.6	6.0	2.5	1.0	-1.4	1.3	-1.5
Pavlov. Cond. magazine entry latency	1.4	1.7	5.2	-2.3	-1.7	-0.1	0.2	0.2
Pavlov. Cond. change in total contacts	1.1	1.8	2.8	-1.7	-0.5	1.4	-1.4	1.4
Pavlov. Cond. index score	1.7	2.2	5.6	-2.4	-1.2	1.2	-1.0	1.3
Pavlov. Cond. latency score	1.5	2.0	6.0	-2.4	-1.4	0.9	-0.8	1.0
Pavlov. Cond. lever contacts	1.8	2.5	4.9	-2.2	-0.8	1.5	-1.4	1.7
Pavlov. Cond. magazine entry number	1.9	2.4	6.8	2.6	2.0	-0.6	0.4	-0.7
Pavlov. Cond. intertrial magazine entries	2.6	3.9	6.1	2.2	2.5	1.6	-1.7	1.6
Pavlov. Cond. lever-magazine prob. diff.	1.6	2.1	5.0	-2.2	-1.1	1.3	-1.1	1.3
Pavlov. Cond. response bias	2.1	2.9	6.3	-2.5	-1.2	1.5	-1.3	1.7
Time in closed arm before self-admin	0.6	0.8	1.1	-1.0	-0.8	-0.8	0.8	-1.1
Time in closed arm after self-admin	2.2	2.3	3.3	-1.4	-1.8	-1.4	1.4	-1.6
Time in open arm before self-admin	0.3	0.3	1.0	1.0	0.6	-0.2	0.2	0.4
Time in open arm after self-admin	1.4	1.6	2.0	1.2	1.4	1.3	-1.3	1.1
Bone: periosteal estimation	1.3	2.7	4.6	0.7	1.0	2.1	-2.1	1.7
Bone: periosteal perimeter	1.1	1.9	3.1	0.6	0.9	1.8	-1.8	1.4
Bone: post-yield work	0.1	0.1	0.3	-0.3	-0.2	-0.3	0.3	-0.6
Progressive ratio test 1 active lever presses	1.0	1.2	1.6	-1.0	-1.1	-1.0	1.0	-1.3
Progressive ratio test 1 breakpoint	1.0	1.2	1.6	-1.0	-1.2	-1.0	1.0	-1.3
Progressive ratio test 1 inactive lever presses	0.8	1.2	1.7	-0.6	-0.8	-1.2	1.2	-1.3
Progressive ratio test 2 active lever presses	0.2	0.2	0.3	-0.6	-0.4	0.4	-0.4	0.4
Progressive ratio test 2 breakpoint	0.2	0.2	0.4	-0.6	-0.4	0.4	-0.4	0.3
Progressive ratio test 2 inactive lever presses	0.0	0.1	0.1	-0.4	-0.3	0.0	-0.0	-0.3
Incentive Sensitization - Responses	0.4	0.5	1.1	-0.2	0.2	0.8	-0.8	1.0
Incentive Sensitization - Breakpoint	0.3	0.5	1.0	-0.2	0.2	0.8	-0.8	1.0
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.4	0.4	0.6	0.1	-0.1	0.1
Progressive ratio	0.7	1.0	2.3	-1.5	-1.5	-0.5	0.5	-0.4
Food seeking constrained by brief footshock	1.1	1.4	1.8	0.6	1.3	1.2	-1.2	1.3
Seeking ratio, punishment vs. effort	2.5	3.6	6.4	2.0	2.5	1.6	-1.6	1.6
Retroperitoneal fat weight	5.0	21.2	34.4	5.9	5.5	3.9	-3.9	3.2
Reaction time number correct	0.6	1.1	2.1	-0.6	-0.5	-1.4	1.3	-1.1
Reaction time mean minus median	0.3	0.7	1.1	0.3	0.7	1.0	-1.0	0.8
Reaction time mean minus median AUC	0.1	0.1	0.2	-0.1	0.3	0.5	-0.5	0.4
Reaction time num false alarms	0.4	0.6	1.6	1.3	0.7	0.4	-0.4	0.6
Reaction time num false alarms AUC	0.1	0.1	0.4	0.6	0.1	0.1	-0.1	0.3
Reaction time trials correct on left	0.6	1.1	2.1	-0.6	-0.5	-1.4	1.3	-1.1
Reaction time trials on left	0.6	1.1	2.1	-0.6	-0.5	-1.4	1.3	-1.1
Reaction time mean	0.2	0.3	0.5	0.7	0.7	0.5	-0.4	0.2
Reaction time mean AUC	0.0	0.1	0.2	0.4	0.3	0.2	-0.1	-0.1
Median of all reaction times	0.1	0.1	0.2	0.5	0.4	0.1	-0.0	-0.1
Reaction time omissions	0.6	0.8	1.6	0.6	0.8	0.8	-0.9	1.3
Reaction time false alarm rate	0.2	0.3	0.6	0.7	0.2	0.6	-0.5	0.6
Reaction time premature initiation rate	4.2	5.8	6.7	2.1	2.6	2.5	-2.4	2.4
Reaction time premature initiations	1.5	2.6	3.9	1.5	2.0	1.5	-1.5	1.6
Std. dev. reaction times	0.9	1.6	2.2	1.0	1.2	1.5	-1.5	1.1
Reaction time trials completed	0.6	1.1	2.1	-0.6	-0.5	-1.4	1.3	-1.1
Reaction time trials AUC	0.4	0.7	1.4	-0.4	-0.3	-1.2	1.0	-0.9
Run reversals in cocaine runway, females	3.7	3.6	4.2	1.9	1.8	1.9	-1.9	2.0
Run reversals in cocaine runway, males	1.1	1.1	2.3	-1.4	-1.5	-0.7	0.7	-0.5
Latency to leave start box in cocaine runway	0.4	0.4	1.2	1.1	0.8	-0.4	0.4	-0.2
Latency to leave start box in cocaine runway, F	1.0	1.2	3.0	1.7	1.4	0.4	-0.4	0.7
Latency to leave start box in cocaine runway, M	0.8	0.7	1.2	-0.5	-0.6	-0.9	0.9	-1.1
Std. dev. time between licks in bursts	2.9	3.9	4.8	1.8	2.2	1.9	-1.9	2.2
Total sessions with >9 infusions	0.4	0.5	1.4	-1.2	-0.8	-0.2	0.2	-0.2
Short access day 1 total inactive lever presses	0.2	0.2	0.6	-0.8	-0.7	-0.2	0.2	-0.1
Short access day 10 total inactive lever presses	0.2	0.4	0.6	0.7	0.4	-0.8	0.8	-0.6
Short access day 1 total infusions	0.2	0.3	0.5	-0.7	-0.2	0.5	-0.5	0.5
Short access day 10 total infusions	0.2	0.3	0.9	-0.9	-0.7	0.1	-0.1	0.2
Short access total infusions	0.4	0.6	1.8	-1.3	-1.0	-0.1	0.1	-0.1
Short access day 1 locomotion	1.4	1.8	4.1	-2.0	-1.7	-0.8	0.8	-0.8
Short access day 10 total locomotion	0.1	0.1	0.4	-0.6	-0.3	0.4	-0.4	-0.1
Short access total locomotion	0.6	0.7	1.1	-1.0	-0.8	-0.7	0.7	-0.9
One hour access (0.3 mA shock)	0.1	0.2	0.3	-0.4	-0.2	0.3	-0.3	0.6
Compulsive drug intake	0.5	0.6	0.9	-0.2	-0.3	-1.0	1.0	-0.9
One hour access (shock baseline)	0.3	0.4	1.3	-1.2	-0.8	0.1	-0.1	0.2
Social response proportion	0.7	0.7	1.9	1.4	1.3	0.2	-0.2	-0.1
Social responses	1.6	2.1	4.0	2.0	1.9	1.1	-1.0	0.9
Social time	0.3	0.4	0.8	0.9	0.5	-0.7	0.7	-0.3
Soleus weight	1.7	5.1	6.3	2.5	2.4	2.1	-2.1	2.1
Bone: stiffness	0.2	0.4	0.8	-0.3	-0.5	-0.6	0.6	-0.9
Tibialis anterior weight	0.3	1.0	1.5	1.0	1.2	0.9	-0.9	0.8
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.2	0.3	0.2	0.4	-0.4	0.1
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.4	-0.6	-0.4	0.2	-0.2	0.2
Time to tail flick, test, before self-admin	0.6	0.7	1.4	0.2	0.1	1.2	-1.2	0.6
Time to tail flick, test, after self-admin	1.1	1.1	1.7	0.6	0.6	1.3	-1.3	1.3
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	1.2	-1.1	-0.9	-0.4	0.4	-0.2
Delta time to tail flick, test, before/after SA	0.2	0.2	0.3	0.3	0.3	-0.5	0.5	-0.1
Tibia length	0.3	0.9	2.2	-1.5	-1.0	-0.6	0.6	-0.6
Ambulatory time before self-admin	0.4	0.6	0.9	-0.4	-0.7	-1.0	1.0	-0.6
Ambulatory time after self-admin	1.9	2.2	3.4	-0.9	-1.0	-1.8	1.8	-1.5
Bone: tissue strength	3.0	3.0	5.5	-0.8	-1.0	-2.0	2.0	-2.3
Total heroin consumption	0.0	0.0	0.1	0.2	0.1	-0.1	0.1	0.2
Bone: trabecular number	0.5	0.9	1.4	-0.3	-0.8	-1.1	1.1	-1.2
Bone: trabecular spacing	0.1	0.1	0.4	-0.7	-0.2	-0.0	0.0	0.4
Bone: trabecular thickness	0.5	0.6	0.9	1.0	0.7	0.7	-0.7	0.6
Bone: trabecular tissue density	1.0	1.5	3.6	1.9	1.7	0.6	-0.6	0.3
Water consumed over 24 hours	0.1	0.2	0.4	0.4	0.2	-0.4	0.4	-0.6
Number of responses in last shaping day	1.8	1.9	3.8	1.9	1.7	0.9	-0.9	1.1