Hub : Genes

LOC103692581

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	alternative TSS	XR_001838302.2	0.11	0.07	1.1e-06	0.03	0.04	0.02	0.03	1.1e-04	5.0e-05	1.4e-03	2.1e-04
2	Brain	gene expression	LOC103692581	0.07	0.05	2.2e-04	0.06	0.04	0.04	0.05	5.8e-06	7.4e-05	4.4e-05	8.2e-06
3	PL	gene expression	LOC103692581	0.05	0.04	6.6e-05	0.05	0.04	0.04	0.04	2.1e-06	3.2e-05	6.0e-05	3.4e-05
4	Adipose	gene expression	LOC103692581	0.31	0.1	0.0e+00	0.13	0.11	0.1	0.12	3.8e-14	2.0e-12	3.1e-11	1.0e-13
5	Adipose	alternative polyA	XR_005505750.1	0.03	0.02	6.4e-03	0	0.01	0.01	0.01	1.0e-01	2.3e-02	1.5e-02	2.4e-02
6	Adipose	alternative polyA	XR_005505751.1	0.03	0.02	6.5e-03	0	0.01	0.01	0.01	1.0e-01	2.3e-02	1.6e-02	2.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	6.9	11.5	13.0	-2.6	-3.5	-3.5	-3.5	-3.6	3.6
Area under the delay curve	0.1	0.1	0.3	-0.5	-0.4	-0.5	-0.5	-0.1	0.0
BMI with tail	2.8	9.1	13.8	3.7	2.9	3.0	2.9	2.7	-2.7
BMI without tail	2.0	4.2	4.6	2.1	2.1	2.1	2.0	2.0	-2.0
Body weight	1.9	8.1	12.2	3.5	2.8	2.8	2.8	2.6	-2.6
Weight adjusted by age	0.1	0.2	0.3	-0.0	-0.5	-0.6	-0.5	-0.2	0.2
Bone surface	2.0	3.4	4.1	-0.9	-2.0	-2.0	-2.0	-2.0	2.0
Bone volume	4.7	8.0	9.4	-1.9	-3.0	-3.0	-3.1	-2.9	2.9
Breakpoint value in progressive ratio session	4.4	4.9	5.3	-2.1	-2.3	-2.3	-2.3	-2.1	2.1
Number of licking bursts	3.3	3.9	5.0	1.8	2.2	2.2	2.2	1.6	-1.6
Context. condit. distance diff. score	1.2	1.5	2.4	-0.4	-1.1	-1.1	-1.1	-1.5	1.6
Locomotion velocity, session 1	0.9	1.0	1.4	1.2	1.0	1.0	1.0	0.8	-0.8
Locomotion distance, session 1	0.2	0.3	0.6	-0.8	-0.5	-0.5	-0.5	-0.4	0.4
Locomotion velocity, session 2	0.5	0.6	1.2	1.1	0.7	0.7	0.7	0.6	-0.6
Locomotion distance, session 2	0.0	0.0	0.1	-0.0	-0.1	-0.1	-0.1	0.3	-0.3
Locomotion velocity, session 3	0.1	0.1	0.2	-0.5	-0.1	-0.1	-0.1	-0.4	0.4
Locomotion distance, session 3	0.6	0.7	1.0	-1.0	-0.7	-0.7	-0.7	-0.9	0.9
Stereotopy head waving bouts, day 3	1.0	1.2	1.8	-1.1	-0.9	-0.9	-0.9	-1.3	1.3
Stereotopy head waving duration, day 3	0.0	0.1	0.1	0.0	-0.2	-0.2	-0.2	-0.3	0.4
Locomotion velocity, session 7	0.1	0.1	0.1	0.0	-0.3	-0.3	-0.3	-0.2	0.2
Locomotion distance, session 7	0.4	0.5	1.0	1.0	0.7	0.7	0.7	0.5	-0.5
Stereotopy head waving bouts, day 7	0.2	0.3	0.3	0.2	0.5	0.5	0.5	0.6	-0.6
Stereotopy head waving duration, day 7	0.0	0.0	0.2	-0.4	0.1	0.1	0.1	-0.0	0.0
Locomotion velocity, session 8	1.2	1.4	2.2	-0.4	-1.1	-1.1	-1.1	-1.5	1.5
Locomotion distance, session 8	2.4	3.5	4.0	-1.3	-1.9	-1.9	-1.9	-2.0	2.0
Degree of sensitization distance	2.6	2.6	4.7	2.2	1.6	1.6	1.6	1.3	-1.3
Degree of sensitization stereotypy	1.2	1.3	1.8	0.6	1.1	1.1	1.1	1.3	-1.3
Conditioned locomotion	3.3	3.9	5.0	-2.0	-1.8	-1.8	-1.8	-2.2	2.2
Cocaine response after cond. corrected	0.2	0.2	0.5	0.7	0.1	0.1	0.1	0.5	-0.5
Cocaine response after cond. not corrected	0.1	0.2	0.4	0.0	0.1	0.2	0.1	0.6	-0.7
Cocaine response before conditioning	0.4	0.5	2.8	-1.7	0.1	0.2	0.1	-0.0	0.0
Saline control response	1.0	1.3	3.2	-1.8	-1.1	-1.0	-1.0	-0.8	0.8
Bone: connectivity density	1.5	2.4	3.9	-1.1	-1.4	-1.4	-1.4	-2.0	2.0
Bone: cortical apparent density	0.8	1.0	1.7	0.5	0.9	0.9	0.9	1.3	-1.3
Bone: cortical area	0.2	0.2	0.4	0.4	-0.6	-0.6	-0.7	-0.3	0.2
Bone: cortical porosity	1.0	1.1	1.4	-0.9	-0.9	-0.9	-1.0	-1.2	1.2
Bone: cortical porosity	0.8	0.9	1.1	-0.7	-0.9	-0.9	-0.9	-1.1	1.1
Bone: cortical thickness	0.2	0.4	0.9	0.7	0.1	0.2	0.1	0.9	-1.0
Bone: cortical thickness	0.6	0.7	1.0	-0.9	-1.0	-1.0	-1.0	-0.5	0.5
Bone: cortical tissue density	0.9	1.2	2.0	0.6	1.0	1.0	1.0	1.4	-1.4
Condit. Reinf. active minus inactive responses	3.4	3.8	5.5	2.4	1.7	1.7	1.7	2.1	-2.1
Condit. Reinf. active-inactive response ratio	1.9	2.1	2.7	1.6	1.3	1.3	1.3	1.5	-1.5
Condit. Reinf. active responses	1.3	1.6	1.9	1.4	1.2	1.2	1.2	1.3	-1.3
Condit. Reinf. inactive responses	0.1	0.1	0.2	-0.4	-0.0	-0.0	-0.0	-0.4	0.5
Incentive salience index mean	1.7	2.1	2.4	1.2	1.4	1.4	1.4	1.5	-1.5
Condit. Reinf. lever presses	0.2	0.3	1.3	-1.1	0.3	0.3	0.3	0.2	-0.3
Condit. Reinf. active minus inactive responses	0.1	0.1	0.1	0.4	-0.3	-0.3	-0.3	-0.1	0.1
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.1	0.3	-0.2	-0.2	-0.3	-0.1	0.1
Condit. Reinf. active responses	0.1	0.1	0.3	0.1	0.0	0.1	-0.0	0.5	-0.6
Condit. Reinf. inactive responses	0.1	0.1	0.3	-0.5	0.0	0.1	0.1	0.5	-0.5
Condit. Reinf. lever presses	0.1	0.1	0.2	-0.1	-0.4	-0.4	-0.4	0.3	-0.4
Condit. Reinf. lever reinforcers received	0.2	0.2	0.6	0.4	0.2	0.2	0.1	0.7	-0.8
Conditioned reinforcement - actives	1.9	1.9	2.8	-1.1	-1.6	-1.7	-1.6	-1.1	1.0
Conditioned reinforcement - inactives	1.2	1.4	2.0	-1.4	-1.2	-1.2	-1.2	-1.1	1.1
Conditioned locomotion	0.5	0.6	1.8	-1.3	-0.6	-0.7	-0.8	0.3	-0.3
Patch foraging indifference point 0 sec	2.8	4.5	5.9	-1.1	-2.4	-2.4	-2.4	-2.1	2.0
Patch foraging indifference point AUC	0.2	0.2	0.3	0.3	0.3	0.4	0.4	-0.5	0.5
Delay disc. indifference point, 0s delay	0.5	0.5	0.9	0.8	0.5	0.5	0.5	0.9	-0.9
Delay disc. indifference point, 16s delay	0.6	0.6	1.0	-1.0	-0.9	-0.9	-0.8	-0.4	0.3
Delay disc. indifference point, 2s delay	0.2	0.2	0.6	0.2	0.3	0.2	0.1	0.7	-0.8
Delay disc. indifference point, 24s delay	4.1	4.0	5.5	-1.7	-2.2	-2.2	-2.3	-1.7	1.7
Delay disc. indifference point, 4s delay	0.1	0.1	0.5	-0.7	0.0	-0.1	-0.1	0.0	-0.0
Delay disc. indifference point, 8s delay	0.7	0.7	1.1	-0.7	-0.9	-1.0	-1.1	-0.5	0.5
Indifference point function ln k	2.0	2.9	4.5	-1.6	-2.0	-2.1	-2.1	-0.9	0.9
Indifference point function log k	2.0	2.9	4.5	-1.6	-2.0	-2.1	-2.1	-0.9	0.9
Patch foraging total patch changes 0 sec	2.8	4.5	5.9	-1.0	-2.4	-2.4	-2.4	-2.1	2.0
Patch foraging total patch changes 12 sec	0.3	0.4	0.6	0.0	-0.6	-0.6	-0.6	-0.8	0.7
Patch foraging total patch changes 18 sec	0.5	0.7	1.8	0.2	-0.4	-0.4	-0.4	-1.3	1.3
Patch foraging total patch changes 24 sec	0.2	0.3	0.4	0.2	-0.5	-0.6	-0.5	-0.6	0.6
Patch foraging total patch changes 6 sec	0.5	0.7	1.1	0.0	-0.9	-0.8	-0.8	-1.0	1.0
Patch foraging time to switch 0 sec	1.7	2.7	3.5	0.9	1.9	1.8	1.8	1.6	-1.6
Patch foraging water rate 0 sec	5.4	8.7	10.8	-2.5	-3.3	-3.2	-3.2	-2.8	2.7
Patch foraging water rate 12 sec	0.1	0.2	0.3	-0.0	-0.6	-0.5	-0.5	0.3	-0.3
Patch foraging water rate 18 sec	2.4	3.3	4.9	-2.2	-2.1	-2.0	-2.0	-1.1	1.0
Patch foraging water rate 24 sec	0.3	0.5	0.8	-0.4	-0.9	-0.8	-0.8	-0.5	0.5
Patch foraging water rate 6 sec	0.9	1.3	2.2	-0.9	-1.5	-1.4	-1.3	-0.7	0.7
Seeking ratio, delayed vs. immediate footshock	0.7	0.8	2.5	1.6	0.7	0.7	0.7	0.5	-0.5
Distance traveled before self-admin	0.0	0.0	0.1	-0.1	-0.2	-0.2	-0.2	0.0	-0.1
Distance traveled after self-admin	1.8	2.0	2.7	-0.4	-1.7	-1.6	-1.7	-1.4	1.4
Extensor digitorum longus weight	1.0	4.0	4.8	-2.2	-2.1	-2.1	-2.1	-1.7	1.7
Bone: elastic displacement	1.1	1.2	1.6	-1.0	-1.2	-1.2	-1.3	-1.0	1.0
Bone: elastic work	1.8	2.4	3.2	-1.3	-1.8	-1.8	-1.8	-1.2	1.2
Bone: endosteal estimation	1.0	2.3	3.3	-0.5	-1.5	-1.5	-1.5	-1.8	1.8
Bone: endosteal perimeter	0.5	1.1	1.7	-0.2	-1.0	-1.0	-1.0	-1.3	1.3
Epididymis fat weight	7.8	18.1	24.7	5.0	4.3	4.4	4.4	3.7	-3.6
Delta time in closed arm before/after self-admin	0.4	0.4	0.4	-0.5	-0.6	-0.6	-0.6	-0.6	0.6
Delta time in open arm before/after self-admin	0.2	0.2	0.4	0.6	0.5	0.5	0.5	0.2	-0.2
Diff in mean of infusions in LGA sessions	1.3	1.4	1.9	-1.4	-1.1	-1.1	-1.1	-1.2	1.2
Delay discount exponential model param	0.3	0.3	0.5	0.7	0.5	0.6	0.7	0.3	-0.3
Extinction: sum of active levers before priming	2.9	2.9	3.7	-1.9	-1.8	-1.7	-1.7	-1.6	1.5
Active lever presses in extinction session 6	3.8	3.6	4.3	-1.1	-2.0	-2.0	-2.0	-2.1	2.0
Bone: final force	0.0	0.0	0.2	0.4	0.2	0.2	0.1	0.1	-0.1
Bone: final moment	0.0	0.0	0.1	0.4	-0.1	-0.1	-0.1	-0.1	0.1
Food consumed during 24 hour testing period	0.7	0.8	1.4	0.7	1.2	1.2	1.1	0.5	-0.5
Glucose	0.3	0.4	1.0	1.0	0.7	0.6	0.6	0.4	-0.4
Heart weight	3.1	4.4	7.2	2.7	2.0	2.0	2.1	1.8	-1.8
Delay discount hyperbolic model param	0.1	0.1	0.3	0.5	0.3	0.4	0.5	0.1	-0.0
Intermittent access intake day 1-15 change	2.9	2.9	3.9	-1.1	-2.0	-1.9	-1.8	-1.6	1.6
Intermittent access intake escalation	3.3	3.2	4.1	-1.0	-2.0	-1.8	-1.8	-1.9	1.9
Intermittent access intake escalation 2	2.0	2.0	2.8	0.0	-1.7	-1.5	-1.5	-1.6	1.6
Intermitt. access day 1 inactive lever presses	0.8	0.8	1.7	0.3	1.3	1.2	0.9	0.7	-0.7
Intermitt. access day 15 inactive lever presses	0.2	0.2	0.4	0.2	0.7	0.7	0.5	-0.3	0.3
Intermitt. access escalation Index	0.4	0.4	1.2	1.1	0.2	0.3	0.2	0.6	-0.6
Intermittent access day 1 total infusions	0.3	0.4	1.6	-1.3	-0.4	-0.5	-0.5	-0.1	0.1
Intermittent access day 15 total infusions	1.5	1.6	2.3	-1.4	-1.5	-1.4	-1.4	-0.8	0.8
Intermittent access terminal intake (last 3 days)	0.8	0.8	1.4	-1.0	-1.2	-1.2	-1.1	-0.3	0.2
Intermittent access total infusions	0.9	1.0	2.8	-1.7	-1.0	-1.0	-1.0	-0.3	0.3
Intermittent access day 1 locomotion	0.7	0.7	1.3	-0.6	0.7	0.7	0.7	1.1	-1.1
Intermittent access day 15 total locomotion	0.4	0.4	0.6	0.2	0.6	0.8	0.7	0.7	-0.7
Intermittent access total locomotion	0.6	0.7	1.4	-0.5	0.6	0.6	0.6	1.2	-1.2
Intermittent access standard deviation	0.8	0.8	1.2	-0.8	-1.0	-1.1	-1.0	-0.8	0.8
Left kidney weight	0.0	0.0	0.1	0.3	-0.2	-0.2	-0.1	-0.0	-0.0
Right kidney weight	0.2	0.5	1.4	1.2	0.6	0.7	0.7	0.5	-0.5
Cocaine induced anxiety	1.1	1.2	2.4	-0.9	-0.7	-0.7	-0.9	-1.5	1.6
Post-drug Anxiety	0.2	0.3	0.4	0.0	0.7	0.7	0.6	-0.4	0.5
Baseline Anxiety	2.7	2.9	3.5	1.3	1.7	1.7	1.9	1.8	-1.7
Tail length	0.2	0.5	2.4	-1.6	-0.3	-0.4	-0.4	-0.4	0.4
Length with tail	0.0	0.0	0.1	-0.1	0.0	0.0	0.0	0.3	-0.4
Length without tail	0.1	0.3	0.6	-0.2	-0.7	-0.7	-0.6	-0.3	0.3
Times rat made contact with spout	1.7	2.0	2.9	-1.7	-1.1	-1.1	-1.0	-1.7	1.7
Lifetime Intake	0.5	0.6	2.5	-1.6	-0.6	-0.6	-0.5	-0.1	0.1
Liver weight, left	1.3	2.1	3.3	1.1	1.3	1.2	1.2	1.8	-1.8
Liver weight, right	2.5	4.2	6.8	2.6	2.1	2.0	2.0	1.7	-1.7
Locomotor activity	1.0	1.6	2.2	1.5	1.3	1.3	1.3	1.2	-1.2
Locomotor testing distance	0.7	1.1	1.4	1.2	1.2	1.1	1.1	0.8	-0.8
Locomotor testing rearing	0.2	0.3	0.4	0.5	0.6	0.7	0.7	0.4	-0.4
Locomotion in novel chamber	1.6	2.0	3.1	0.6	1.3	1.4	1.4	1.7	-1.7
Locomotion in novel chamber post-restriction	1.4	1.7	2.2	1.0	1.5	1.5	1.5	1.2	-1.2
Fecal boli incidents, locomotor time 1	1.8	1.9	3.5	-1.9	-1.2	-1.3	-1.3	-1.3	1.3
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	0.2	0.4	0.3	0.2	0.2	-0.2
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.4	0.1	0.6	0.4	0.4	-0.1	0.1
Bouts of movement, locomotor time 1	0.2	0.3	1.5	-1.2	-0.1	-0.1	-0.1	-0.2	0.2
Total resting periods, locomotor time 1	0.3	0.3	1.3	-1.2	0.0	-0.0	-0.1	-0.4	0.4
Rest time, locomotor task time 1	0.2	0.2	0.7	-0.8	0.4	0.3	0.3	-0.0	0.0
Distance moved, locomotor task time 1	0.3	0.4	0.8	0.9	0.4	0.4	0.4	0.7	-0.7
Vertical activity count, locomotor time 1	0.1	0.2	0.3	0.4	-0.2	-0.3	-0.2	0.5	-0.6
Time >=10cm from walls, locomotor time 2	0.2	0.2	0.4	-0.1	0.6	0.6	0.4	-0.1	0.2
Bouts of movement, locomotor time 2	0.0	0.0	0.1	-0.2	0.1	0.2	0.1	0.2	-0.2
Total resting periods, locomotor time 2	0.0	0.0	0.1	-0.2	0.2	0.3	0.2	0.2	-0.2
Rest time, locomotor task time 2	0.1	0.1	0.3	0.0	0.4	0.3	0.5	0.0	-0.0
Distance moved, locomotor task time 2	0.1	0.1	0.3	0.1	0.0	0.0	-0.1	0.5	-0.5
Vertical activity count, locomotor time 2	0.1	0.1	0.2	-0.4	-0.4	-0.4	-0.4	-0.0	0.0
Light reinforcement 1	0.1	0.2	0.3	-0.5	-0.5	-0.5	-0.6	-0.2	0.2
Light reinforcement 2	0.1	0.2	0.8	-0.9	-0.1	-0.2	-0.2	-0.2	0.2
Bone: marrow area	1.0	2.1	3.0	-0.4	-1.4	-1.4	-1.5	-1.7	1.7
Bone: maximum diameter	1.4	2.6	3.1	-0.4	-1.8	-1.7	-1.8	-1.7	1.7
Bone: maximum force	0.0	0.1	0.1	0.1	-0.3	-0.3	-0.4	-0.3	0.3
Bone: maximum moment	0.2	0.3	0.4	0.0	-0.6	-0.6	-0.7	-0.5	0.5
Mean time between licks in bursts	0.4	0.6	1.1	1.1	0.7	0.7	0.8	0.6	-0.6
Mean num. licks in bursts	6.3	7.5	8.1	-2.7	-2.9	-2.8	-2.9	-2.6	2.6
Cd content in liver	0.2	0.2	1.1	1.0	0.3	0.3	0.3	-0.2	0.2
Co content in liver	1.9	2.2	3.1	-1.4	-1.8	-1.8	-1.8	-1.1	1.0
Cu content in liver	0.3	0.3	1.6	1.3	0.3	0.4	0.4	0.2	-0.1
Fe content in liver	0.9	1.1	2.0	-0.7	-0.8	-0.9	-0.9	-1.4	1.4
K content in liver	2.4	2.4	3.5	1.2	1.9	1.8	1.8	1.1	-1.1
Mg content in liver	0.9	0.9	1.3	1.0	1.1	1.2	1.2	0.6	-0.6
Mn content in liver	0.2	0.2	0.5	0.3	-0.1	0.1	0.1	0.7	-0.7
Na content in liver	0.2	0.2	1.2	-1.1	0.0	-0.1	-0.1	-0.1	0.1
Rb content in liver	0.1	0.2	0.3	0.3	0.4	0.5	0.5	-0.3	0.4
Se content in liver	0.8	0.9	1.3	0.4	1.0	1.1	1.1	1.0	-1.0
Sr content in liver	0.3	0.3	0.7	-0.8	-0.5	-0.5	-0.5	-0.2	0.2
Zn content in liver	3.7	4.1	4.9	2.2	2.0	2.0	2.0	2.0	-2.0
Bone: minimum diameter	0.3	0.5	2.3	1.5	0.2	0.2	0.1	0.5	-0.5
Time in familiar zone, hab. session 1	0.6	0.5	0.8	0.7	0.6	0.6	0.6	0.9	-0.9
Time in novel zone, hab. session 1	0.1	0.1	0.5	0.7	0.1	0.1	0.1	-0.3	0.3
Total zone transitions, hab. session 1	0.2	0.2	0.9	-0.9	-0.2	-0.2	-0.2	-0.4	0.4
Total locomotion distance, hab. session 1	0.4	0.5	1.5	-1.2	-0.6	-0.6	-0.6	-0.4	0.4
Locomotion velocity, hab. session 1	0.4	0.6	2.4	-1.6	-0.5	-0.5	-0.5	-0.4	0.3
Time in familiar zone, hab. session 2	0.0	0.0	0.1	0.0	0.1	0.1	0.1	0.2	-0.2
Time in novel zone, hab. session 2	0.3	0.3	1.2	1.1	0.5	0.5	0.5	0.1	-0.1
Total zone transitions, hab. session 2	0.6	0.7	1.7	-1.3	-0.5	-0.5	-0.5	-1.0	1.0
Total locomotion distance, hab. session 2	0.7	0.9	1.7	-1.3	-0.6	-0.6	-0.7	-1.2	1.2
Locomotion velocity, hab. session 2	0.9	1.2	2.4	-1.5	-0.7	-0.7	-0.7	-1.3	1.3
Novel to familiar place preference ratio	0.1	0.1	0.4	0.6	-0.1	-0.1	-0.1	-0.2	0.2
Novelty place preference	0.2	0.2	0.9	1.0	0.2	0.2	0.2	0.2	-0.2
Time in novel zone, NPP test	0.2	0.2	1.0	1.0	0.1	0.1	0.1	0.1	-0.1
Total zone transitions, NPP test	0.5	0.7	1.4	-1.2	-0.5	-0.5	-0.5	-1.1	1.1
Total locomotion distance, NPP test	1.1	1.5	2.5	-1.6	-0.9	-0.9	-0.9	-1.4	1.4
Locomotion velocity, NPP test	1.4	2.0	3.9	-2.0	-1.1	-1.1	-1.1	-1.5	1.5
Intraocular pressure	0.8	1.1	4.3	2.1	0.7	0.5	0.5	0.8	-0.8
Delta distance traveled before/after self-admin	0.4	0.5	0.9	0.2	-0.6	-0.6	-0.6	-0.9	0.9
Delta ambulatory time before/after self-admin	1.4	1.6	2.1	-0.3	-1.3	-1.3	-1.3	-1.5	1.4
Parametrial fat weight	9.5	18.5	22.3	4.7	4.2	4.2	4.2	4.2	-4.3
Pavlov. Cond. lever latency	0.2	0.2	0.6	0.8	-0.4	-0.4	-0.4	0.1	-0.1
Pavlov. Cond. magazine entry latency	0.2	0.3	0.5	-0.7	-0.3	-0.3	-0.3	-0.7	0.7
Pavlov. Cond. change in total contacts	0.3	0.4	0.6	-0.7	-0.8	-0.8	-0.8	-0.2	0.2
Pavlov. Cond. index score	0.2	0.2	0.9	-1.0	0.1	0.1	0.1	-0.3	0.3
Pavlov. Cond. latency score	0.2	0.2	0.7	-0.9	0.4	0.4	0.4	-0.3	0.3
Pavlov. Cond. lever contacts	0.2	0.3	1.3	-1.2	-0.0	-0.0	-0.0	-0.4	0.4
Pavlov. Cond. magazine entry number	0.2	0.3	0.7	0.8	0.2	0.2	0.2	0.7	-0.7
Pavlov. Cond. intertrial magazine entries	1.4	1.7	2.3	-1.5	-1.4	-1.4	-1.4	-1.0	1.0
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	1.8	-1.3	-0.4	-0.4	-0.4	-0.7	0.7
Pavlov. Cond. response bias	1.4	1.8	3.1	-1.8	-1.1	-1.1	-1.1	-1.4	1.4
Pavlov. Cond. lever latency	0.3	0.4	0.5	0.7	0.5	0.5	0.5	0.7	-0.7
Pavlov. Cond. magazine entry latency	0.5	0.6	1.2	1.1	0.8	0.9	0.9	0.1	-0.1
Pavlov. Cond. change in total contacts	0.3	0.4	0.6	0.8	0.8	0.8	0.8	0.2	-0.2
Pavlov. Cond. index score	0.1	0.1	0.1	0.2	0.3	0.3	0.3	-0.2	0.3
Pavlov. Cond. latency score	0.1	0.1	0.2	0.2	0.2	0.2	0.2	-0.4	0.4
Pavlov. Cond. lever contacts	0.0	0.0	0.1	-0.2	0.0	0.1	0.0	-0.3	0.3
Pavlov. Cond. magazine entry number	0.8	0.9	1.7	-1.3	-1.1	-1.1	-1.1	-0.3	0.3
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.5	0.2	-0.4	-0.4	-0.4	0.6	-0.7
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	0.4	0.4	0.5	0.5	-0.1	0.1
Pavlov. Cond. response bias	0.1	0.1	0.2	-0.0	0.2	0.2	0.2	-0.4	0.5
Time in closed arm before self-admin	0.1	0.1	0.1	-0.0	0.3	0.3	0.3	-0.2	0.3
Time in closed arm after self-admin	0.5	0.5	0.6	0.7	0.7	0.7	0.7	0.8	-0.8
Time in open arm before self-admin	0.1	0.1	0.4	-0.3	0.2	0.2	0.2	0.6	-0.6
Time in open arm after self-admin	0.1	0.1	0.4	-0.6	-0.3	-0.3	-0.3	-0.2	0.2
Bone: periosteal estimation	1.0	2.0	2.6	-0.2	-1.6	-1.6	-1.6	-1.5	1.5
Bone: periosteal perimeter	0.7	1.1	1.4	-0.3	-1.1	-1.1	-1.1	-1.2	1.2
Bone: post-yield work	1.0	1.4	2.4	-1.1	-0.9	-0.9	-0.9	-1.5	1.6
Progressive ratio test 1 active lever presses	1.2	1.3	1.9	-0.4	1.4	1.3	1.1	1.2	-1.2
Progressive ratio test 1 breakpoint	0.9	0.9	1.4	-0.6	1.2	1.0	0.8	1.0	-1.0
Progressive ratio test 1 inactive lever presses	0.6	0.6	1.2	-0.7	1.1	1.0	0.9	0.4	-0.3
Progressive ratio test 2 active lever presses	0.3	0.3	0.7	-0.8	-0.6	-0.6	-0.6	-0.2	0.2
Progressive ratio test 2 breakpoint	0.5	0.6	1.1	-1.0	-0.9	-0.8	-0.8	-0.3	0.3
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.2	-0.4	-0.2	-0.1	-0.1	-0.4	0.5
Incentive Sensitization - Responses	1.2	1.2	2.5	-0.3	-1.6	-1.5	-1.4	-0.5	0.5
Incentive Sensitization - Breakpoint	1.0	1.0	2.2	-0.2	-1.5	-1.3	-1.3	-0.3	0.2
Sum of active levers in priming session hrs 5-6	1.5	1.5	1.7	-1.0	-1.2	-1.2	-1.2	-1.3	1.3
Progressive ratio	0.2	0.3	0.5	0.6	0.7	0.7	0.6	0.1	-0.0
Food seeking constrained by brief footshock	5.4	6.6	9.2	-3.0	-2.3	-2.3	-2.3	-2.7	2.7
Seeking ratio, punishment vs. effort	2.1	2.6	3.2	-1.8	-1.7	-1.7	-1.7	-1.4	1.4
Retroperitoneal fat weight	18.5	60.8	86.6	9.3	7.5	7.6	7.6	7.3	-7.3
Reaction time number correct	0.0	0.1	0.1	0.3	0.3	0.3	0.3	0.0	-0.0
Reaction time mean minus median	0.8	1.1	1.4	1.2	1.0	1.0	1.0	1.1	-1.0
Reaction time mean minus median AUC	0.9	1.2	1.9	1.4	1.1	1.0	0.9	1.1	-1.1
Reaction time num false alarms	0.2	0.2	0.4	0.5	0.6	0.5	0.6	-0.1	0.1
Reaction time num false alarms AUC	0.2	0.2	0.4	0.5	0.6	0.6	0.6	0.2	-0.2
Reaction time trials correct on left	0.0	0.1	0.1	0.3	0.3	0.3	0.3	0.0	-0.0
Reaction time trials on left	0.1	0.1	0.1	0.4	0.3	0.4	0.3	0.1	-0.1
Reaction time mean	0.2	0.2	0.6	0.8	0.1	-0.1	-0.1	0.6	-0.6
Reaction time mean AUC	0.2	0.3	0.7	0.8	0.1	-0.2	-0.1	0.6	-0.6
Median of all reaction times	0.1	0.1	0.2	0.5	-0.1	-0.4	-0.3	0.4	-0.4
Reaction time omissions	1.2	1.6	2.1	1.5	1.5	1.4	1.4	0.8	-0.8
Reaction time false alarm rate	0.1	0.1	0.2	0.3	0.4	0.4	0.4	0.3	-0.3
Reaction time premature initiation rate	0.3	0.3	1.3	-1.1	-0.1	-0.1	-0.1	-0.6	0.6
Reaction time premature initiations	0.2	0.2	0.7	-0.8	0.1	0.1	0.1	-0.5	0.5
Std. dev. reaction times	0.4	0.5	1.3	1.1	0.6	0.4	0.5	0.8	-0.8
Reaction time trials completed	0.1	0.1	0.1	0.4	0.3	0.4	0.3	0.1	-0.1
Reaction time trials AUC	0.1	0.1	0.2	0.4	0.4	0.4	0.4	0.3	-0.2
Run reversals in cocaine runway, females	1.7	1.6	2.0	-0.9	-1.3	-1.4	-1.4	-1.4	1.3
Run reversals in cocaine runway, males	0.4	0.4	0.7	-0.5	-0.8	-0.8	-0.8	-0.2	0.2
Latency to leave start box in cocaine runway	3.0	3.3	5.6	-1.3	-1.5	-1.5	-1.5	-2.3	2.4
Latency to leave start box in cocaine runway, F	2.1	2.3	3.5	-0.9	-1.4	-1.4	-1.4	-1.9	1.9
Latency to leave start box in cocaine runway, M	2.9	2.7	4.1	-1.5	-1.5	-1.4	-1.4	-2.0	2.0
Std. dev. time between licks in bursts	0.0	0.0	0.1	0.2	-0.2	-0.2	-0.2	-0.2	0.2
Total sessions with >9 infusions	0.7	0.8	3.2	-1.8	0.2	0.1	0.2	0.9	-0.9
Short access day 1 total inactive lever presses	0.3	0.3	1.5	-1.2	0.4	0.3	0.3	0.3	-0.3
Short access day 10 total inactive lever presses	0.3	0.3	0.5	0.3	0.6	0.7	0.7	-0.5	0.6
Short access day 1 total infusions	0.3	0.3	1.3	-1.1	0.4	0.3	0.3	0.4	-0.4
Short access day 10 total infusions	0.7	0.8	3.9	-2.0	-0.5	-0.5	-0.5	-0.1	0.1
Short access total infusions	0.5	0.6	3.0	-1.7	-0.4	-0.4	-0.3	-0.1	0.1
Short access day 1 locomotion	0.3	0.4	1.7	-1.3	-0.3	-0.4	-0.4	0.3	-0.3
Short access day 10 total locomotion	0.3	0.4	0.5	-0.2	0.6	0.6	0.6	0.7	-0.7
Short access total locomotion	0.5	0.5	0.8	-0.9	0.5	0.4	0.4	0.9	-0.9
One hour access (0.3 mA shock)	2.9	3.3	4.1	-1.7	-2.0	-2.0	-1.9	-1.7	1.6
Compulsive drug intake	0.2	0.2	0.5	0.7	0.4	0.4	0.3	-0.4	0.4
One hour access (shock baseline)	1.3	1.6	3.0	-1.7	-1.4	-1.3	-1.3	-0.7	0.7
Social response proportion	0.2	0.2	0.4	-0.1	-0.6	-0.6	-0.6	0.1	-0.1
Social responses	0.1	0.2	0.8	0.9	0.1	0.2	0.1	0.2	-0.2
Social time	0.3	0.5	1.0	-0.9	-0.1	0.1	-0.0	1.0	-1.0
Soleus weight	3.7	11.0	13.9	-3.7	-3.3	-3.3	-3.3	-3.2	3.1
Bone: stiffness	0.1	0.2	0.8	0.9	0.4	0.4	0.4	0.2	-0.2
Tibialis anterior weight	0.9	3.0	5.1	-2.3	-1.7	-1.6	-1.6	-1.6	1.6
Time to tail flick, vehicle, before self-admin	1.6	1.6	2.3	0.4	1.3	1.3	1.3	1.5	-1.5
Time to tail flick, vehicle, after self-admin	3.7	3.9	5.1	2.0	2.3	2.2	2.2	1.5	-1.5
Time to tail flick, test, before self-admin	2.1	2.0	3.2	-1.5	-1.8	-1.7	-1.7	-0.8	0.7
Time to tail flick, test, after self-admin	0.6	0.6	1.8	-1.4	-0.8	-0.8	-0.8	-0.0	0.0
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	1.1	1.0	0.7	0.7	0.7	0.2	-0.1
Delta time to tail flick, test, before/after SA	0.3	0.3	1.0	-1.0	-0.3	-0.4	-0.4	-0.4	0.4
Tibia length	1.5	4.2	6.5	2.5	1.9	1.9	1.9	2.0	-2.0
Ambulatory time before self-admin	0.0	0.0	0.1	0.1	-0.2	-0.3	-0.3	0.2	-0.2
Ambulatory time after self-admin	1.4	1.5	2.1	0.1	-1.4	-1.4	-1.4	-1.3	1.2
Bone: tissue strength	0.3	0.2	0.4	0.2	-0.6	-0.6	-0.6	0.4	-0.4
Total heroin consumption	3.3	3.8	4.5	-2.1	-1.9	-1.9	-1.9	-2.0	1.9
Bone: trabecular number	5.2	8.1	8.5	-2.5	-2.9	-2.9	-2.9	-2.9	2.9
Bone: trabecular spacing	4.0	5.2	5.9	1.9	2.3	2.3	2.3	2.4	-2.4
Bone: trabecular thickness	4.8	5.7	6.6	-1.8	-2.6	-2.6	-2.6	-2.4	2.4
Bone: trabecular tissue density	0.1	0.1	0.1	-0.2	0.3	0.3	0.4	-0.2	0.2
Water consumed over 24 hours	0.3	0.4	1.1	0.1	-0.3	-0.3	-0.2	-1.0	1.0
Number of responses in last shaping day	0.2	0.2	1.0	-1.0	-0.2	-0.2	-0.1	-0.3	0.3