Cd44

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Cd44	0.03	0.04	2.8e-03	0.01	0.01	0.01	0.01	9.9e-03	1.2e-02	2.0e-02	7.8e-03
2	Brain	gene expression	Cd44	0.14	0.09	3.5e-12	0.13	0.12	0.12	0.12	5.1e-12	8.0e-11	5.1e-11	7.1e-11
3	NAcc	alternative polyA	XM_008762058.3	0.03	0.02	3.7e-04	0.02	0.03	0.01	0.02	1.3e-03	5.1e-04	1.5e-02	3.7e-03
4	NAcc	alternative polyA	NM_012924.3	0.03	0.02	4.4e-04	0.02	0.03	0.01	0.01	1.2e-03	5.9e-04	1.5e-02	8.9e-03
5	PL	gene expression	Cd44	0.02	0.02	3.6e-03	0.02	0.02	0.02	0.02	2.6e-03	1.3e-03	1.4e-03	9.3e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.6	1.0	1.2	1.0	1.0	-1.0	1.0	-1.1
Area under the delay curve	0.4	0.4	0.4	-0.5	-0.6	0.6	-0.7	0.6
BMI with tail	0.1	0.4	0.8	0.9	0.6	-0.7	0.7	-0.3
BMI without tail	0.4	0.9	1.3	1.0	1.1	-1.0	1.0	-0.5
Body weight	0.4	1.7	3.5	1.9	0.9	-1.3	1.3	-0.9
Weight adjusted by age	2.2	2.5	2.7	-1.6	-1.5	1.6	-1.6	1.5
Bone surface	0.4	0.7	1.0	1.0	0.7	-0.8	0.8	-0.7
Bone volume	1.5	2.5	2.6	1.6	1.5	-1.6	1.6	-1.5
Breakpoint value in progressive ratio session	1.3	1.4	1.7	-1.3	-1.0	1.2	-1.2	1.2
Number of licking bursts	0.1	0.1	0.2	0.4	0.0	-0.3	0.3	-0.5
Context. condit. distance diff. score	2.8	3.4	6.2	1.7	1.3	-1.8	1.8	-2.5
Locomotion velocity, session 1	0.0	0.0	0.1	-0.3	0.1	0.1	-0.1	0.1
Locomotion distance, session 1	0.1	0.1	0.3	-0.0	0.5	-0.3	0.3	-0.4
Locomotion velocity, session 2	0.0	0.0	0.1	-0.3	-0.1	0.1	-0.1	0.1
Locomotion distance, session 2	0.3	0.5	0.7	0.6	0.8	-0.7	0.7	-0.6
Locomotion velocity, session 3	0.2	0.2	0.4	0.3	0.7	-0.5	0.5	-0.5
Locomotion distance, session 3	0.3	0.4	0.4	0.6	0.7	-0.6	0.6	-0.6
Stereotopy head waving bouts, day 3	0.1	0.1	0.1	0.1	0.4	-0.2	0.2	-0.3
Stereotopy head waving duration, day 3	0.5	0.6	0.9	0.6	0.8	-0.8	0.8	-0.9
Locomotion velocity, session 7	0.2	0.3	0.3	0.3	0.6	-0.5	0.5	-0.5
Locomotion distance, session 7	0.2	0.2	0.3	-0.5	-0.5	0.5	-0.5	0.4
Stereotopy head waving bouts, day 7	0.0	0.0	0.1	0.3	-0.1	-0.2	0.2	-0.3
Stereotopy head waving duration, day 7	0.0	0.0	0.0	0.1	-0.1	-0.0	0.0	0.0
Locomotion velocity, session 8	0.7	0.9	1.0	0.8	0.8	-1.0	1.0	-1.0
Locomotion distance, session 8	3.4	5.0	6.8	2.1	1.9	-2.2	2.3	-2.6
Degree of sensitization distance	0.5	0.5	0.7	-0.7	-0.8	0.7	-0.7	0.4
Degree of sensitization stereotypy	0.0	0.0	0.1	0.0	-0.4	0.1	-0.1	0.2
Conditioned locomotion	4.2	4.9	6.6	-2.1	-2.6	2.3	-2.3	1.8
Cocaine response after cond. corrected	2.2	2.5	3.0	-1.5	-1.5	1.5	-1.5	1.7
Cocaine response after cond. not corrected	0.6	0.6	0.7	-0.8	-0.8	0.8	-0.8	0.8
Cocaine response before conditioning	4.4	5.3	7.0	2.3	2.0	-2.3	2.3	-2.6
Saline control response	0.7	0.9	1.1	0.8	1.0	-1.0	1.0	-1.0
Bone: connectivity density	0.4	0.6	0.7	0.8	0.8	-0.8	0.8	-0.8
Bone: cortical apparent density	0.1	0.1	0.2	-0.2	-0.3	0.3	-0.3	0.4
Bone: cortical area	0.1	0.1	0.2	0.5	-0.1	-0.1	0.0	0.4
Bone: cortical porosity	0.5	0.5	0.6	-0.7	-0.7	0.7	-0.7	0.7
Bone: cortical porosity	0.4	0.4	0.5	-0.5	-0.7	0.6	-0.6	0.6
Bone: cortical thickness	0.1	0.2	0.7	0.0	-0.2	0.3	-0.3	0.9
Bone: cortical thickness	5.0	5.8	6.4	-2.1	-2.5	2.4	-2.4	2.5
Bone: cortical tissue density	0.0	0.0	0.1	-0.1	-0.2	0.2	-0.2	0.3
Condit. Reinf. active minus inactive responses	1.0	1.2	1.7	1.1	0.9	-1.1	1.1	-1.3
Condit. Reinf. active-inactive response ratio	1.7	1.9	2.7	1.7	1.1	-1.4	1.3	-1.4
Condit. Reinf. active responses	0.3	0.4	0.6	0.6	0.5	-0.6	0.6	-0.8
Condit. Reinf. inactive responses	0.3	0.3	0.6	-0.8	-0.5	0.6	-0.6	0.4
Incentive salience index mean	0.9	1.1	1.3	1.1	1.0	-1.0	1.0	-1.1
Condit. Reinf. lever presses	0.6	0.8	0.9	1.0	1.0	-0.9	0.9	-0.7
Condit. Reinf. active minus inactive responses	1.5	1.9	3.8	1.0	1.1	-1.3	1.3	-1.9
Condit. Reinf. active-inactive response ratio	3.4	3.6	5.6	1.7	1.7	-1.8	1.8	-2.4
Condit. Reinf. active responses	0.9	1.3	2.2	1.0	0.9	-1.1	1.1	-1.5
Condit. Reinf. inactive responses	0.0	0.0	0.0	0.1	-0.2	0.1	-0.1	0.1
Condit. Reinf. lever presses	0.6	0.9	1.5	0.7	0.9	-0.9	0.9	-1.2
Condit. Reinf. lever reinforcers received	1.0	1.5	2.6	1.0	1.1	-1.1	1.2	-1.6
Conditioned reinforcement - actives	3.4	3.4	3.8	1.9	2.0	-1.9	1.9	-1.6
Conditioned reinforcement - inactives	8.2	9.3	12.4	3.0	3.5	-3.1	3.1	-2.5
Conditioned locomotion	2.6	3.2	4.7	2.2	1.7	-1.8	1.8	-1.3
Patch foraging indifference point 0 sec	0.1	0.2	0.4	-0.6	-0.5	0.5	-0.5	0.2
Patch foraging indifference point AUC	1.1	1.3	1.7	-1.3	-0.9	1.1	-1.1	1.3
Delay disc. indifference point, 0s delay	0.1	0.1	0.1	-0.1	-0.2	0.2	-0.3	0.3
Delay disc. indifference point, 16s delay	2.4	2.4	2.9	-1.4	-1.5	1.6	-1.6	1.7
Delay disc. indifference point, 2s delay	0.4	0.4	0.6	-0.8	-0.7	0.7	-0.7	0.4
Delay disc. indifference point, 24s delay	0.3	0.3	0.5	-0.5	-0.7	0.5	-0.5	0.3
Delay disc. indifference point, 4s delay	0.4	0.4	0.5	-0.6	-0.7	0.7	-0.7	0.6
Delay disc. indifference point, 8s delay	0.2	0.2	0.4	0.4	0.4	-0.4	0.4	-0.6
Indifference point function ln k	0.4	0.5	1.4	1.2	0.4	-0.7	0.7	-0.5
Indifference point function log k	0.4	0.5	1.4	1.2	0.4	-0.7	0.7	-0.5
Patch foraging total patch changes 0 sec	0.1	0.1	0.3	-0.5	-0.4	0.4	-0.3	0.1
Patch foraging total patch changes 12 sec	0.2	0.2	0.4	0.1	0.6	-0.5	0.5	-0.4
Patch foraging total patch changes 18 sec	0.3	0.4	0.8	-0.9	-0.7	0.6	-0.6	0.4
Patch foraging total patch changes 24 sec	0.8	1.0	1.6	-1.3	-1.0	1.0	-1.0	0.7
Patch foraging total patch changes 6 sec	0.1	0.1	0.4	-0.6	-0.2	0.3	-0.3	0.1
Patch foraging time to switch 0 sec	0.1	0.1	0.3	-0.2	0.3	-0.2	0.2	-0.5
Patch foraging water rate 0 sec	0.1	0.1	0.3	0.1	-0.5	0.3	-0.3	0.5
Patch foraging water rate 12 sec	0.5	0.8	1.6	-0.6	-1.3	0.8	-0.8	0.7
Patch foraging water rate 18 sec	0.5	0.6	1.2	1.1	0.4	-0.8	0.8	-0.8
Patch foraging water rate 24 sec	0.5	0.6	1.1	-0.4	-1.1	0.8	-0.8	0.7
Patch foraging water rate 6 sec	0.1	0.2	0.5	-0.0	-0.7	0.3	-0.3	0.4
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.3	0.3	0.5	-0.3	0.2	0.3
Distance traveled before self-admin	0.4	0.5	0.8	0.9	0.6	-0.7	0.7	-0.5
Distance traveled after self-admin	0.4	0.4	0.6	0.8	0.7	-0.7	0.6	-0.5
Extensor digitorum longus weight	0.4	1.5	1.6	-1.1	-1.2	1.2	-1.2	1.2
Bone: elastic displacement	2.0	2.2	2.4	-1.5	-1.3	1.5	-1.5	1.6
Bone: elastic work	1.6	2.1	2.9	-1.3	-1.2	1.5	-1.5	1.7
Bone: endosteal estimation	0.3	0.6	1.2	-0.6	-1.1	0.8	-0.8	0.6
Bone: endosteal perimeter	0.2	0.4	0.7	0.8	0.3	-0.7	0.6	-0.8
Epididymis fat weight	0.8	1.8	2.5	1.6	1.2	-1.3	1.3	-1.2
Delta time in closed arm before/after self-admin	0.1	0.1	0.2	0.2	0.0	-0.2	0.2	-0.5
Delta time in open arm before/after self-admin	0.6	0.6	1.0	-0.5	-0.6	0.8	-0.8	1.0
Diff in mean of infusions in LGA sessions	0.7	0.7	1.8	-0.6	-0.4	0.8	-0.8	1.3
Delay discount exponential model param	0.4	0.4	0.5	0.6	0.7	-0.7	0.7	-0.6
Extinction: sum of active levers before priming	0.5	0.5	0.8	0.9	0.6	-0.8	0.8	-0.4
Active lever presses in extinction session 6	0.7	0.6	0.9	0.7	0.7	-0.8	0.8	-1.0
Bone: final force	0.0	0.0	0.1	-0.0	-0.2	0.2	-0.2	0.3
Bone: final moment	0.1	0.2	0.4	-0.3	-0.5	0.5	-0.5	0.6
Food consumed during 24 hour testing period	6.5	7.9	8.4	2.9	2.8	-2.8	2.8	-2.6
Glucose	2.3	3.5	4.1	1.7	1.9	-1.9	1.9	-2.0
Heart weight	0.5	0.7	1.3	-0.8	-1.1	0.9	-0.9	0.3
Delay discount hyperbolic model param	0.3	0.3	0.4	0.6	0.6	-0.6	0.6	-0.5
Intermittent access intake day 1-15 change	0.1	0.1	0.1	0.3	0.1	-0.2	0.2	-0.2
Intermittent access intake escalation	0.3	0.3	0.4	0.7	0.4	-0.5	0.5	-0.5
Intermittent access intake escalation 2	1.9	1.9	2.7	1.6	1.3	-1.4	1.4	-1.1
Intermitt. access day 1 inactive lever presses	0.1	0.1	0.2	-0.1	-0.4	0.3	-0.3	0.4
Intermitt. access day 15 inactive lever presses	2.8	3.1	4.8	2.2	1.9	-1.8	1.7	-1.0
Intermitt. access escalation Index	0.1	0.1	0.2	-0.1	0.2	-0.2	0.2	-0.4
Intermittent access day 1 total infusions	3.9	4.5	4.7	2.2	2.1	-2.2	2.2	-2.0
Intermittent access day 15 total infusions	4.6	5.2	5.9	2.4	2.3	-2.3	2.3	-2.0
Intermittent access terminal intake (last 3 days)	5.8	6.4	7.2	2.7	2.6	-2.6	2.5	-2.2
Intermittent access total infusions	5.5	6.1	7.2	2.7	2.6	-2.5	2.5	-2.0
Intermittent access day 1 locomotion	1.8	1.9	2.3	1.5	1.3	-1.4	1.4	-1.3
Intermittent access day 15 total locomotion	2.8	3.0	3.5	1.9	1.7	-1.8	1.8	-1.6
Intermittent access total locomotion	2.7	3.1	4.1	2.0	1.8	-1.8	1.8	-1.3
Intermittent access standard deviation	5.9	6.3	8.4	2.9	2.4	-2.5	2.5	-2.1
Left kidney weight	0.6	1.6	2.9	1.7	1.0	-1.2	1.2	-1.0
Right kidney weight	0.6	1.6	2.8	1.7	1.1	-1.3	1.2	-0.8
Cocaine induced anxiety	0.1	0.1	0.3	0.5	0.5	-0.3	0.3	0.1
Post-drug Anxiety	0.1	0.1	0.3	0.2	0.0	0.2	-0.2	0.6
Baseline Anxiety	2.4	2.5	3.0	-1.4	-1.5	1.6	-1.6	1.7
Tail length	0.3	0.9	1.1	1.1	0.9	-1.0	1.0	-0.8
Length with tail	0.2	0.7	1.7	1.3	0.3	-0.8	0.8	-0.8
Length without tail	0.1	0.3	0.8	0.9	0.0	-0.4	0.4	-0.5
Times rat made contact with spout	0.1	0.1	0.2	0.4	0.4	-0.3	0.3	-0.2
Lifetime Intake	5.7	6.4	7.7	2.8	2.7	-2.6	2.6	-2.0
Liver weight, left	0.2	0.4	0.7	0.5	0.5	-0.5	0.5	-0.8
Liver weight, right	1.0	1.7	2.4	1.6	1.3	-1.3	1.3	-1.2
Locomotor activity	0.1	0.1	0.6	0.1	-0.0	-0.2	0.2	-0.8
Locomotor testing distance	1.2	2.0	3.5	1.3	1.0	-1.3	1.4	-1.9
Locomotor testing rearing	0.2	0.4	1.3	0.3	0.1	-0.4	0.5	-1.2
Locomotion in novel chamber	0.5	0.7	0.8	0.9	0.9	-0.8	0.8	-0.7
Locomotion in novel chamber post-restriction	1.4	1.6	2.3	-1.2	-1.5	1.3	-1.3	1.1
Fecal boli incidents, locomotor time 1	9.3	10.1	11.3	-3.2	-3.4	3.2	-3.2	2.9
Change in fecal boli incidents, locomotor task	8.0	7.6	8.4	2.7	2.9	-2.8	2.8	-2.6
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.2	-0.4	-0.5	0.3	-0.2	-0.2
Bouts of movement, locomotor time 1	1.6	1.7	2.3	-1.1	-1.2	1.3	-1.4	1.5
Total resting periods, locomotor time 1	1.3	1.4	1.8	-1.0	-1.2	1.2	-1.3	1.3
Rest time, locomotor task time 1	0.7	0.7	0.8	-0.7	-0.9	0.9	-0.9	0.8
Distance moved, locomotor task time 1	1.9	2.1	3.0	1.5	1.7	-1.5	1.5	-0.9
Vertical activity count, locomotor time 1	0.1	0.1	0.2	0.3	0.4	-0.4	0.4	-0.1
Time >=10cm from walls, locomotor time 2	6.1	6.5	7.2	2.5	2.4	-2.6	2.6	-2.7
Bouts of movement, locomotor time 2	0.0	0.0	0.1	-0.1	-0.3	0.2	-0.2	0.0
Total resting periods, locomotor time 2	0.0	0.0	0.1	-0.0	-0.2	0.1	-0.1	-0.1
Rest time, locomotor task time 2	1.6	1.8	2.6	-1.5	-1.6	1.4	-1.3	0.8
Distance moved, locomotor task time 2	2.9	3.4	5.4	2.1	2.3	-1.9	1.8	-0.8
Vertical activity count, locomotor time 2	1.9	2.1	2.8	1.7	1.7	-1.5	1.4	-0.8
Light reinforcement 1	0.2	0.3	0.6	0.5	0.8	-0.6	0.6	-0.4
Light reinforcement 2	0.0	0.1	0.2	0.1	0.2	-0.0	-0.0	0.5
Bone: marrow area	0.3	0.6	1.2	-0.6	-1.1	0.8	-0.8	0.6
Bone: maximum diameter	0.1	0.1	0.3	0.6	0.0	-0.3	0.2	-0.1
Bone: maximum force	0.0	0.0	0.1	0.3	-0.1	-0.1	0.1	0.1
Bone: maximum moment	0.1	0.1	0.3	-0.1	-0.5	0.3	-0.3	0.5
Mean time between licks in bursts	0.9	1.2	2.0	-1.0	-1.4	1.1	-1.1	0.7
Mean num. licks in bursts	0.0	0.0	0.2	0.0	0.4	-0.2	0.2	0.0
Cd content in liver	1.9	2.0	2.6	1.2	1.6	-1.4	1.4	-1.4
Co content in liver	1.7	2.0	2.3	-1.4	-1.3	1.4	-1.4	1.5
Cu content in liver	0.9	1.1	1.5	-0.7	-1.2	1.0	-1.0	1.2
Fe content in liver	0.7	0.9	1.4	-1.2	-1.0	1.0	-1.0	0.5
K content in liver	2.4	2.4	4.3	-1.3	-1.3	1.4	-1.5	2.1
Mg content in liver	2.7	2.7	4.0	-1.4	-1.5	1.6	-1.6	2.0
Mn content in liver	1.7	1.9	2.2	-1.5	-1.4	1.4	-1.4	1.2
Na content in liver	0.2	0.2	0.2	-0.3	-0.4	0.5	-0.5	0.5
Rb content in liver	1.4	1.7	2.3	-1.4	-0.9	1.3	-1.3	1.5
Se content in liver	4.5	5.5	5.7	-2.3	-2.4	2.4	-2.4	2.3
Sr content in liver	0.4	0.4	0.7	-0.3	-0.8	0.6	-0.6	0.6
Zn content in liver	0.2	0.2	0.3	-0.4	-0.4	0.4	-0.4	0.6
Bone: minimum diameter	0.2	0.5	1.2	1.1	0.3	-0.7	0.6	-0.4
Time in familiar zone, hab. session 1	0.4	0.4	0.4	-0.7	-0.6	0.6	-0.6	0.6
Time in novel zone, hab. session 1	0.6	0.6	0.8	0.9	0.7	-0.8	0.8	-0.7
Total zone transitions, hab. session 1	2.7	3.8	4.2	1.8	1.9	-2.0	2.0	-2.0
Total locomotion distance, hab. session 1	1.2	1.7	2.2	1.2	1.1	-1.3	1.4	-1.5
Locomotion velocity, hab. session 1	0.8	1.2	1.4	1.0	1.0	-1.1	1.1	-1.2
Time in familiar zone, hab. session 2	0.1	0.1	0.3	0.4	0.2	-0.1	0.1	0.5
Time in novel zone, hab. session 2	0.1	0.1	0.3	-0.3	-0.1	0.0	0.0	-0.5
Total zone transitions, hab. session 2	2.1	2.7	3.0	1.6	1.7	-1.7	1.7	-1.5
Total locomotion distance, hab. session 2	0.1	0.1	0.1	0.3	0.2	-0.3	0.4	-0.3
Locomotion velocity, hab. session 2	0.0	0.0	0.1	0.2	0.1	-0.3	0.3	-0.2
Novel to familiar place preference ratio	1.0	1.0	1.2	1.1	1.0	-1.1	1.0	-0.9
Novelty place preference	0.9	0.9	1.1	1.1	0.9	-1.0	1.0	-0.8
Time in novel zone, NPP test	0.6	0.6	0.7	0.8	0.8	-0.8	0.8	-0.7
Total zone transitions, NPP test	0.3	0.5	1.1	-1.0	-0.5	0.7	-0.7	0.4
Total locomotion distance, NPP test	0.2	0.3	0.5	-0.7	-0.6	0.5	-0.5	0.1
Locomotion velocity, NPP test	0.1	0.2	0.3	-0.6	-0.5	0.4	-0.4	0.1
Intraocular pressure	0.0	0.0	0.1	-0.0	0.3	-0.2	0.2	-0.3
Delta distance traveled before/after self-admin	0.2	0.2	0.3	-0.5	-0.5	0.4	-0.4	0.2
Delta ambulatory time before/after self-admin	0.1	0.1	0.2	-0.3	-0.5	0.3	-0.3	0.1
Parametrial fat weight	1.0	1.9	2.1	1.3	1.4	-1.4	1.4	-1.2
Pavlov. Cond. lever latency	0.5	0.7	1.0	-0.7	-1.0	0.8	-0.8	0.7
Pavlov. Cond. magazine entry latency	1.3	1.7	1.9	1.2	1.4	-1.3	1.3	-1.3
Pavlov. Cond. change in total contacts	0.2	0.2	0.5	-0.3	-0.4	0.4	-0.4	0.7
Pavlov. Cond. index score	0.5	0.6	0.8	0.7	0.9	-0.8	0.8	-0.6
Pavlov. Cond. latency score	0.5	0.6	0.9	0.7	1.0	-0.8	0.8	-0.5
Pavlov. Cond. lever contacts	0.3	0.3	0.4	0.5	0.6	-0.6	0.6	-0.5
Pavlov. Cond. magazine entry number	1.3	1.6	1.9	-1.1	-1.4	1.3	-1.3	1.2
Pavlov. Cond. intertrial magazine entries	0.0	0.1	0.1	-0.4	-0.2	0.2	-0.2	-0.1
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	0.7	0.6	0.8	-0.7	0.7	-0.5
Pavlov. Cond. response bias	0.9	1.1	1.3	0.9	1.1	-1.1	1.1	-1.1
Pavlov. Cond. lever latency	2.6	3.5	5.4	-1.4	-1.9	1.8	-1.8	2.3
Pavlov. Cond. magazine entry latency	1.1	1.2	1.4	1.0	1.2	-1.1	1.1	-1.2
Pavlov. Cond. change in total contacts	1.0	1.3	1.8	1.0	1.2	-1.1	1.1	-1.3
Pavlov. Cond. index score	2.1	2.7	3.6	1.4	1.7	-1.6	1.6	-1.9
Pavlov. Cond. latency score	2.7	3.3	4.1	1.6	1.9	-1.8	1.8	-2.0
Pavlov. Cond. lever contacts	2.6	3.6	5.2	1.6	1.9	-1.8	1.9	-2.3
Pavlov. Cond. magazine entry number	0.6	0.8	1.0	-0.8	-1.0	0.8	-0.8	0.9
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.1	-0.2	-0.3	0.2	-0.2	0.1
Pavlov. Cond. lever-magazine prob. diff.	1.7	2.2	2.9	1.3	1.5	-1.4	1.5	-1.7
Pavlov. Cond. response bias	2.1	2.9	4.3	1.3	1.7	-1.6	1.6	-2.1
Time in closed arm before self-admin	0.6	0.7	1.0	0.7	1.0	-0.8	0.8	-0.8
Time in closed arm after self-admin	0.4	0.4	0.8	0.6	0.5	-0.6	0.6	-0.9
Time in open arm before self-admin	0.6	0.6	1.1	-0.9	-1.1	0.8	-0.7	0.2
Time in open arm after self-admin	1.5	1.7	1.8	-1.2	-1.4	1.3	-1.3	1.3
Bone: periosteal estimation	0.2	0.3	0.7	-0.1	-0.8	0.5	-0.5	0.6
Bone: periosteal perimeter	0.8	1.4	2.2	1.5	1.0	-1.2	1.2	-0.9
Bone: post-yield work	0.0	0.0	0.1	-0.1	-0.3	0.1	-0.1	-0.2
Progressive ratio test 1 active lever presses	3.5	3.7	4.2	1.9	2.0	-2.0	2.0	-1.6
Progressive ratio test 1 breakpoint	3.1	3.3	3.6	1.8	1.8	-1.9	1.9	-1.6
Progressive ratio test 1 inactive lever presses	2.2	2.4	2.5	1.6	1.5	-1.6	1.6	-1.4
Progressive ratio test 2 active lever presses	2.6	2.8	4.2	1.8	2.0	-1.7	1.7	-0.9
Progressive ratio test 2 breakpoint	3.1	3.4	5.1	1.9	2.3	-1.9	1.9	-1.1
Progressive ratio test 2 inactive lever presses	3.2	3.7	4.9	2.2	2.2	-2.0	1.9	-1.1
Incentive Sensitization - Responses	1.3	1.3	2.8	1.1	1.7	-1.1	1.1	-0.3
Incentive Sensitization - Breakpoint	1.1	1.1	2.5	1.0	1.6	-1.0	1.0	-0.3
Sum of active levers in priming session hrs 5-6	0.5	0.5	1.2	-0.4	-0.6	0.6	-0.6	1.1
Progressive ratio	0.4	0.5	0.8	0.8	0.9	-0.7	0.7	-0.3
Food seeking constrained by brief footshock	1.0	1.3	1.6	1.2	1.2	-1.2	1.2	-0.8
Seeking ratio, punishment vs. effort	0.2	0.2	0.4	-0.5	-0.6	0.4	-0.4	0.3
Retroperitoneal fat weight	8.3	27.4	30.6	5.5	4.9	-5.3	5.3	-5.2
Reaction time number correct	0.0	0.0	0.1	-0.2	0.1	0.1	-0.1	0.2
Reaction time mean minus median	0.5	0.7	1.2	0.6	1.1	-0.9	0.9	-0.7
Reaction time mean minus median AUC	0.3	0.4	0.6	0.5	0.8	-0.7	0.7	-0.4
Reaction time num false alarms	1.2	1.7	2.0	-1.3	-1.4	1.4	-1.3	1.1
Reaction time num false alarms AUC	2.0	2.8	3.3	-1.6	-1.8	1.7	-1.7	1.4
Reaction time trials correct on left	0.0	0.0	0.1	-0.2	0.1	0.1	-0.1	0.2
Reaction time trials on left	0.0	0.0	0.1	-0.4	0.0	0.2	-0.2	0.2
Reaction time mean	0.3	0.4	0.6	0.5	0.8	-0.6	0.6	-0.5
Reaction time mean AUC	0.3	0.4	0.7	0.7	0.8	-0.6	0.6	-0.5
Median of all reaction times	0.4	0.6	0.8	0.7	0.9	-0.7	0.7	-0.7
Reaction time omissions	0.7	0.9	1.3	-1.1	-0.9	0.9	-0.9	0.8
Reaction time false alarm rate	2.3	3.2	4.0	-1.6	-2.0	1.8	-1.8	1.6
Reaction time premature initiation rate	0.1	0.2	0.4	-0.6	-0.5	0.4	-0.4	0.0
Reaction time premature initiations	0.1	0.2	0.4	-0.7	-0.3	0.4	-0.4	0.1
Std. dev. reaction times	0.0	0.1	0.2	0.1	0.4	-0.2	0.2	-0.1
Reaction time trials completed	0.0	0.0	0.1	-0.4	0.0	0.2	-0.2	0.2
Reaction time trials AUC	0.0	0.0	0.1	-0.2	0.3	-0.1	0.1	0.0
Run reversals in cocaine runway, females	0.1	0.1	0.2	0.5	0.3	-0.2	0.2	-0.4
Run reversals in cocaine runway, males	3.9	3.8	4.0	-2.0	-1.9	2.0	-2.0	2.0
Latency to leave start box in cocaine runway	0.0	0.1	0.2	-0.2	-0.4	0.2	-0.2	0.0
Latency to leave start box in cocaine runway, F	0.0	0.0	0.1	0.1	0.0	-0.2	0.2	-0.3
Latency to leave start box in cocaine runway, M	0.4	0.4	0.6	-0.5	-0.6	0.6	-0.6	0.8
Std. dev. time between licks in bursts	0.6	0.7	1.0	-0.9	-1.0	0.9	-0.9	0.4
Total sessions with >9 infusions	1.6	1.8	2.2	1.5	1.2	-1.4	1.4	-1.3
Short access day 1 total inactive lever presses	0.8	0.9	1.4	0.7	0.9	-1.0	1.0	-1.2
Short access day 10 total inactive lever presses	0.1	0.2	0.3	0.5	0.5	-0.4	0.4	0.0
Short access day 1 total infusions	6.9	7.3	8.3	2.9	2.8	-2.8	2.7	-2.4
Short access day 10 total infusions	3.1	3.5	4.4	2.1	1.8	-1.9	1.9	-1.6
Short access total infusions	4.3	4.8	5.7	2.4	2.1	-2.2	2.2	-2.0
Short access day 1 locomotion	3.4	3.7	5.0	2.1	1.4	-1.9	1.9	-2.2
Short access day 10 total locomotion	3.8	4.3	5.7	2.4	2.0	-2.1	2.1	-1.7
Short access total locomotion	3.3	3.4	4.3	2.1	1.6	-1.8	1.8	-1.9
One hour access (0.3 mA shock)	3.9	4.6	5.8	2.4	2.3	-2.2	2.2	-1.5
Compulsive drug intake	1.1	1.1	1.3	-1.1	-1.0	1.1	-1.0	1.0
One hour access (shock baseline)	5.9	6.8	7.7	2.8	2.8	-2.7	2.6	-2.2
Social response proportion	4.6	5.0	5.2	-2.3	-2.2	2.2	-2.2	2.2
Social responses	0.1	0.1	0.1	0.3	0.2	-0.3	0.3	-0.2
Social time	2.0	2.6	3.1	-1.8	-1.2	1.6	-1.6	1.7
Soleus weight	1.5	4.3	4.8	-1.9	-2.2	2.1	-2.1	2.1
Bone: stiffness	0.3	0.5	0.8	0.9	0.4	-0.7	0.7	-0.7
Tibialis anterior weight	3.2	11.0	11.4	-3.2	-3.3	3.4	-3.4	3.2
Time to tail flick, vehicle, before self-admin	4.5	4.6	6.6	2.3	2.6	-2.2	2.2	-1.1
Time to tail flick, vehicle, after self-admin	4.8	5.2	6.4	2.3	2.5	-2.3	2.3	-1.9
Time to tail flick, test, before self-admin	0.7	0.7	1.0	1.0	0.9	-0.8	0.8	-0.7
Time to tail flick, test, after self-admin	1.9	2.0	2.5	1.6	1.4	-1.4	1.4	-1.2
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.3	-0.1	-0.0	0.0	-0.0	-0.6
Delta time to tail flick, test, before/after SA	0.2	0.2	0.3	0.3	0.2	-0.4	0.4	-0.5
Tibia length	0.2	0.7	0.9	-0.7	-0.8	0.8	-0.8	1.0
Ambulatory time before self-admin	0.2	0.2	0.4	0.6	0.4	-0.4	0.4	-0.0
Ambulatory time after self-admin	0.3	0.4	0.6	0.8	0.5	-0.6	0.6	-0.5
Bone: tissue strength	0.0	0.0	0.1	0.0	0.0	0.1	-0.1	0.2
Total heroin consumption	0.8	1.0	1.1	-0.9	-1.0	1.0	-1.0	1.1
Bone: trabecular number	0.4	0.6	0.7	0.7	0.7	-0.7	0.7	-0.8
Bone: trabecular spacing	0.4	0.5	0.7	0.6	0.8	-0.7	0.7	-0.6
Bone: trabecular thickness	0.1	0.2	0.2	0.5	0.3	-0.4	0.4	-0.3
Bone: trabecular tissue density	1.1	1.6	2.3	-1.0	-1.3	1.2	-1.2	1.5
Water consumed over 24 hours	0.0	0.0	0.2	0.4	0.1	-0.2	0.1	-0.0
Number of responses in last shaping day	0.9	0.9	1.2	1.1	1.1	-1.0	0.9	-0.4