Cd44

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Cd44	0.03	0.04	6.1e-03	0.02	0.01	0.01	0.01	5.4e-03	1.6e-02	6.9e-02	9.4e-03
2	Brain	gene expression	Cd44	0.12	0.08	1.8e-11	0.13	0.1	0.12	0.11	6.1e-12	1.2e-09	7.0e-11	4.2e-10
3	NAcc	alternative polyA	NM_012924.3	0.03	0.02	4.4e-05	0.04	0.03	0.03	0.03	4.3e-06	6.4e-05	7.7e-06	8.1e-06
4	NAcc	alternative polyA	XM_006234631.5	0.03	0.02	9.3e-05	0.03	0.02	0.03	0.03	8.0e-06	1.1e-04	1.3e-05	1.4e-05
5	PL	gene expression	Cd44	0.02	0.02	1.3e-03	0.02	0.02	0.02	0.02	1.5e-03	2.4e-03	2.4e-03	3.8e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.8	1.5	1.7	1.1	-1.0	1.3	-1.3	-1.3
Area under the delay curve	0.2	0.3	0.4	-0.4	0.5	-0.5	0.5	0.6
BMI with tail	0.0	0.0	0.1	-0.1	0.3	-0.0	0.0	0.3
BMI without tail	0.0	0.1	0.3	0.5	-0.3	0.2	-0.2	-0.3
Body weight	0.1	0.6	1.5	1.2	-0.5	0.8	-0.8	-0.5
Weight adjusted by age	1.8	2.8	3.2	-1.8	1.5	-1.6	1.6	1.7
Bone surface	0.4	0.8	1.2	1.1	-0.7	0.8	-0.8	-0.9
Bone volume	1.7	3.1	3.3	1.8	-1.6	1.8	-1.8	-1.7
Breakpoint value in progressive ratio session	1.1	1.3	1.7	-1.3	1.2	-1.2	1.2	1.0
Number of licking bursts	0.0	0.0	0.1	0.4	-0.1	0.0	-0.0	0.0
Context. condit. distance diff. score	2.0	2.5	3.3	1.8	-1.3	1.4	-1.4	-1.8
Locomotion velocity, session 1	0.0	0.0	0.1	-0.2	-0.0	-0.1	0.1	0.3
Locomotion distance, session 1	0.1	0.1	0.1	0.1	-0.3	0.3	-0.3	-0.4
Locomotion velocity, session 2	0.0	0.0	0.1	-0.2	0.2	-0.3	0.3	-0.1
Locomotion distance, session 2	0.2	0.3	0.5	0.7	-0.7	0.6	-0.6	-0.4
Locomotion velocity, session 3	0.2	0.2	0.3	0.3	-0.6	0.5	-0.5	-0.5
Locomotion distance, session 3	0.4	0.4	0.5	0.4	-0.5	0.7	-0.7	-0.7
Stereotopy head waving bouts, day 3	0.1	0.1	0.3	-0.0	-0.5	0.3	-0.3	-0.3
Stereotopy head waving duration, day 3	0.4	0.4	0.7	0.5	-0.9	0.6	-0.6	-0.6
Locomotion velocity, session 7	0.5	0.5	0.9	0.2	-0.7	0.8	-0.8	-1.0
Locomotion distance, session 7	0.1	0.1	0.2	-0.5	0.5	-0.2	0.2	-0.1
Stereotopy head waving bouts, day 7	0.0	0.0	0.0	-0.1	0.2	-0.1	0.1	0.1
Stereotopy head waving duration, day 7	0.0	0.0	0.1	-0.1	0.0	-0.1	0.1	0.3
Locomotion velocity, session 8	0.7	0.8	1.0	0.9	-1.0	0.7	-0.7	-1.0
Locomotion distance, session 8	2.7	3.9	4.9	2.2	-1.8	1.8	-1.8	-2.2
Degree of sensitization distance	0.4	0.4	0.6	-0.5	0.7	-0.7	0.7	0.4
Degree of sensitization stereotypy	0.1	0.1	0.1	-0.1	0.4	-0.3	0.3	0.2
Conditioned locomotion	5.1	5.8	6.3	-2.1	2.4	-2.5	2.5	2.5
Cocaine response after cond. corrected	2.2	2.6	3.1	-1.6	1.6	-1.6	1.6	1.7
Cocaine response after cond. not corrected	0.9	1.0	1.2	-0.9	1.1	-1.0	1.0	1.1
Cocaine response before conditioning	3.3	3.9	4.6	2.1	-1.8	1.9	-1.9	-2.1
Saline control response	0.7	0.9	1.2	0.8	-0.7	1.1	-1.1	-1.1
Bone: connectivity density	0.4	0.7	0.7	0.8	-0.7	0.8	-0.8	-0.8
Bone: cortical apparent density	0.0	0.0	0.0	0.2	0.2	-0.1	0.1	0.1
Bone: cortical area	0.1	0.1	0.3	0.5	-0.2	0.2	-0.2	-0.1
Bone: cortical porosity	0.1	0.1	0.2	-0.4	0.4	-0.4	0.4	0.2
Bone: cortical porosity	0.4	0.4	0.6	-0.6	0.7	-0.8	0.8	0.5
Bone: cortical thickness	0.0	0.0	0.0	0.0	0.1	-0.1	0.1	0.1
Bone: cortical thickness	5.5	6.5	7.5	-2.1	2.5	-2.7	2.7	2.6
Bone: cortical tissue density	0.0	0.0	0.0	0.2	0.2	-0.1	0.1	0.1
Condit. Reinf. active minus inactive responses	0.7	0.8	1.1	1.0	-0.8	1.0	-1.0	-0.8
Condit. Reinf. active-inactive response ratio	1.3	1.4	2.6	1.6	-1.1	1.1	-1.1	-0.9
Condit. Reinf. active responses	0.2	0.2	0.3	0.5	-0.3	0.5	-0.5	-0.4
Condit. Reinf. inactive responses	0.3	0.4	0.5	-0.7	0.6	-0.6	0.6	0.5
Incentive salience index mean	0.6	0.7	1.1	1.1	-0.7	0.9	-0.9	-0.6
Condit. Reinf. lever presses	0.3	0.5	0.7	0.9	-0.5	0.8	-0.8	-0.4
Condit. Reinf. active minus inactive responses	0.6	0.8	1.0	0.8	-0.9	0.9	-0.9	-1.0
Condit. Reinf. active-inactive response ratio	2.2	2.6	3.0	1.5	-1.6	1.6	-1.6	-1.7
Condit. Reinf. active responses	0.3	0.5	0.6	0.7	-0.7	0.8	-0.8	-0.5
Condit. Reinf. inactive responses	0.1	0.2	0.5	-0.1	0.4	-0.3	0.3	0.7
Condit. Reinf. lever presses	0.6	0.8	1.0	0.7	-0.8	1.0	-1.0	-0.9
Condit. Reinf. lever reinforcers received	0.5	0.6	0.8	0.7	-0.8	0.9	-0.9	-0.7
Conditioned reinforcement - actives	2.5	4.3	4.9	2.2	-2.2	2.0	-2.0	-2.0
Conditioned reinforcement - inactives	6.6	9.7	11.2	3.0	-3.3	3.1	-3.1	-3.0
Conditioned locomotion	1.4	1.9	3.1	1.8	-1.3	1.2	-1.2	-1.2
Patch foraging indifference point 0 sec	0.1	0.1	0.3	-0.5	0.4	-0.1	0.1	0.5
Patch foraging indifference point AUC	0.5	0.7	1.5	-1.2	0.9	-0.6	0.6	0.8
Delay disc. indifference point, 0s delay	0.0	0.0	0.1	-0.1	0.2	-0.0	0.0	0.3
Delay disc. indifference point, 16s delay	1.9	2.0	2.5	-1.5	1.6	-1.3	1.3	1.5
Delay disc. indifference point, 2s delay	0.7	0.8	0.9	-0.8	0.7	-0.9	0.9	0.9
Delay disc. indifference point, 24s delay	0.2	0.2	0.4	-0.5	0.7	-0.2	0.2	0.3
Delay disc. indifference point, 4s delay	0.7	0.7	1.1	-0.7	0.7	-0.9	0.9	1.0
Delay disc. indifference point, 8s delay	0.1	0.2	0.2	0.4	-0.4	0.4	-0.4	-0.4
Indifference point function ln k	0.2	0.4	1.6	1.3	-0.4	0.3	-0.3	-0.3
Indifference point function log k	0.2	0.4	1.6	1.3	-0.4	0.3	-0.3	-0.3
Patch foraging total patch changes 0 sec	0.0	0.1	0.1	-0.4	0.3	0.1	-0.1	0.3
Patch foraging total patch changes 12 sec	0.5	0.6	1.2	0.1	-0.6	1.1	-1.1	-0.4
Patch foraging total patch changes 18 sec	0.3	0.5	1.1	-1.1	0.7	-0.2	0.2	0.8
Patch foraging total patch changes 24 sec	0.4	0.7	1.7	-1.3	1.2	-0.4	0.4	0.5
Patch foraging total patch changes 6 sec	0.1	0.2	0.4	-0.6	0.3	0.4	-0.4	0.0
Patch foraging time to switch 0 sec	0.1	0.1	0.2	-0.2	-0.4	0.3	-0.3	-0.4
Patch foraging water rate 0 sec	0.1	0.1	0.2	0.0	0.5	-0.3	0.3	0.5
Patch foraging water rate 12 sec	0.5	1.1	1.7	-0.8	1.3	-1.1	1.1	0.9
Patch foraging water rate 18 sec	0.3	0.5	1.2	1.1	-0.5	0.7	-0.7	-0.5
Patch foraging water rate 24 sec	0.5	0.8	1.1	-0.5	0.9	-1.0	1.0	0.7
Patch foraging water rate 6 sec	0.2	0.3	0.6	-0.1	0.7	-0.7	0.7	0.4
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.4	0.4	-0.4	0.7	-0.7	-0.3
Distance traveled before self-admin	0.0	0.0	0.1	0.3	-0.0	-0.1	0.1	0.1
Distance traveled after self-admin	0.0	0.0	0.0	0.1	0.1	0.1	-0.1	0.2
Extensor digitorum longus weight	0.2	1.0	1.4	-1.0	1.2	-0.9	0.9	0.9
Bone: elastic displacement	1.3	1.5	2.0	-1.4	1.3	-1.1	1.1	1.0
Bone: elastic work	0.9	1.2	1.8	-1.3	1.2	-1.0	1.0	0.8
Bone: endosteal estimation	0.3	0.7	0.9	-0.5	0.8	-0.9	0.9	0.9
Bone: endosteal perimeter	0.1	0.3	0.7	0.8	-0.6	0.4	-0.4	-0.3
Epididymis fat weight	1.0	3.5	4.8	2.2	-1.7	1.9	-1.9	-1.6
Delta time in closed arm before/after self-admin	0.2	0.2	0.2	-0.2	0.4	-0.5	0.5	0.4
Delta time in open arm before/after self-admin	0.1	0.1	0.3	0.6	-0.5	0.0	-0.0	0.0
Diff in mean of infusions in LGA sessions	1.6	2.0	2.7	-1.3	1.1	-1.5	1.5	1.6
Delay discount exponential model param	0.3	0.3	0.5	0.5	-0.6	0.6	-0.6	-0.7
Extinction: sum of active levers before priming	0.0	0.0	0.1	0.1	0.1	-0.3	0.3	0.1
Active lever presses in extinction session 6	0.3	0.3	0.7	0.5	-0.6	0.3	-0.3	-0.8
Bone: final force	0.0	0.0	0.1	0.2	-0.3	0.1	-0.1	-0.1
Bone: final moment	0.0	0.0	0.0	-0.0	-0.1	0.0	-0.0	0.0
Food consumed during 24 hour testing period	6.0	8.2	8.4	2.9	-2.8	2.9	-2.9	-2.8
Glucose	2.1	3.4	3.7	1.8	-1.8	1.9	-1.9	-1.8
Heart weight	0.7	1.1	1.5	-1.1	1.2	-1.0	1.0	0.8
Delay discount hyperbolic model param	0.4	0.4	0.6	0.5	-0.6	0.7	-0.7	-0.8
Intermittent access intake day 1-15 change	0.2	0.5	0.9	0.9	-0.6	0.7	-0.7	-0.7
Intermittent access intake escalation	0.4	0.8	1.1	1.1	-0.7	0.8	-0.8	-0.9
Intermittent access intake escalation 2	1.4	1.6	2.4	1.6	-1.1	1.2	-1.2	-1.2
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.1	0.2	0.3	-0.0	0.0	0.1
Intermitt. access day 15 inactive lever presses	0.4	0.9	1.9	1.4	-0.8	0.8	-0.8	-0.7
Intermitt. access escalation Index	0.0	0.0	0.1	-0.3	0.1	0.0	-0.0	-0.3
Intermittent access day 1 total infusions	2.6	4.2	5.4	2.3	-2.2	1.9	-1.9	-2.0
Intermittent access day 15 total infusions	3.1	4.6	6.3	2.5	-2.2	1.9	-1.9	-2.0
Intermittent access terminal intake (last 3 days)	2.9	3.8	5.3	2.3	-2.0	1.8	-1.8	-1.8
Intermittent access total infusions	3.5	4.2	6.0	2.4	-2.2	1.8	-1.8	-1.8
Intermittent access day 1 locomotion	1.8	2.3	3.4	1.9	-1.5	1.4	-1.4	-1.5
Intermittent access day 15 total locomotion	1.1	1.9	3.0	1.7	-1.4	1.2	-1.2	-1.3
Intermittent access total locomotion	1.6	1.9	3.5	1.9	-1.4	1.1	-1.1	-1.2
Intermittent access standard deviation	2.0	4.1	7.0	2.6	-2.0	1.9	-1.9	-1.7
Left kidney weight	0.7	3.2	5.7	2.4	-1.6	1.6	-1.6	-1.6
Right kidney weight	1.4	6.3	8.9	3.0	-2.2	2.5	-2.5	-2.4
Cocaine induced anxiety	0.1	0.2	0.2	-0.5	0.3	-0.4	0.4	0.5
Post-drug Anxiety	1.9	2.0	2.5	-1.6	1.3	-1.3	1.3	1.6
Baseline Anxiety	1.3	1.5	1.6	-1.2	1.2	-1.2	1.2	1.3
Tail length	0.3	1.1	2.0	1.4	-0.9	0.9	-0.9	-1.2
Length with tail	0.4	1.9	3.1	1.8	-1.1	1.3	-1.3	-1.3
Length without tail	0.5	1.7	2.6	1.6	-1.2	1.4	-1.4	-0.9
Times rat made contact with spout	0.1	0.2	0.2	0.5	-0.5	0.4	-0.4	0.3
Lifetime Intake	3.2	3.9	5.7	2.4	-2.2	1.8	-1.8	-1.7
Liver weight, left	1.4	2.3	2.6	1.4	-1.3	1.6	-1.6	-1.6
Liver weight, right	1.0	1.7	2.6	1.6	-1.3	1.3	-1.3	-0.8
Locomotor activity	0.0	0.0	0.1	-0.0	0.2	0.2	-0.2	-0.3
Locomotor testing distance	0.8	1.4	1.9	1.2	-0.8	1.2	-1.2	-1.4
Locomotor testing rearing	0.1	0.1	0.5	0.2	-0.1	0.3	-0.3	-0.7
Locomotion in novel chamber	0.9	1.1	1.6	1.2	-1.3	0.9	-0.9	-0.9
Locomotion in novel chamber post-restriction	1.0	1.6	1.9	-1.2	1.3	-1.4	1.4	1.0
Fecal boli incidents, locomotor time 1	7.5	10.9	11.4	-3.1	3.3	-3.4	3.4	3.4
Change in fecal boli incidents, locomotor task	8.2	8.1	9.2	2.8	-3.0	2.8	-2.8	-2.8
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.2	-0.4	0.4	-0.3	0.3	0.0
Bouts of movement, locomotor time 1	1.6	1.8	2.4	-1.0	1.1	-1.6	1.6	1.5
Total resting periods, locomotor time 1	1.4	1.5	1.9	-0.9	1.1	-1.4	1.4	1.3
Rest time, locomotor task time 1	1.1	1.4	2.0	-0.8	1.0	-1.4	1.4	1.2
Distance moved, locomotor task time 1	1.5	2.3	2.9	1.4	-1.7	1.6	-1.6	-1.3
Vertical activity count, locomotor time 1	0.0	0.1	0.1	0.3	-0.3	0.4	-0.4	-0.3
Time >=10cm from walls, locomotor time 2	4.0	5.9	6.2	2.4	-2.4	2.4	-2.4	-2.5
Bouts of movement, locomotor time 2	0.1	0.2	0.3	-0.3	0.5	-0.5	0.5	0.2
Total resting periods, locomotor time 2	0.1	0.1	0.2	-0.2	0.4	-0.4	0.4	0.1
Rest time, locomotor task time 2	2.1	2.7	3.6	-1.4	1.6	-1.9	1.9	1.3
Distance moved, locomotor task time 2	3.9	4.7	6.1	2.2	-2.5	2.2	-2.2	-1.8
Vertical activity count, locomotor time 2	2.0	2.7	3.0	1.7	-1.7	1.7	-1.7	-1.4
Light reinforcement 1	0.3	0.6	0.8	0.7	-0.8	0.9	-0.9	-0.6
Light reinforcement 2	0.0	0.0	0.1	0.3	-0.2	0.1	-0.1	0.2
Bone: marrow area	0.3	0.7	0.9	-0.5	0.8	-0.9	0.9	0.9
Bone: maximum diameter	0.0	0.1	0.3	0.6	-0.3	0.1	-0.1	-0.1
Bone: maximum force	0.1	0.2	0.4	0.6	-0.5	0.4	-0.4	-0.5
Bone: maximum moment	0.0	0.0	0.1	0.2	-0.2	0.1	-0.1	-0.3
Mean time between licks in bursts	0.7	1.8	2.3	-1.0	1.3	-1.5	1.5	1.2
Mean num. licks in bursts	0.1	0.1	0.2	0.2	-0.4	0.4	-0.4	-0.2
Cd content in liver	4.7	5.2	6.2	1.7	-2.4	2.5	-2.5	-2.2
Co content in liver	1.4	1.7	2.7	-1.3	1.1	-1.2	1.2	1.6
Cu content in liver	2.1	2.5	3.1	-1.2	1.6	-1.8	1.8	1.6
Fe content in liver	0.9	1.1	1.4	-0.8	1.1	-1.2	1.2	0.9
K content in liver	3.6	3.5	4.9	-1.7	1.7	-1.8	1.8	2.2
Mg content in liver	2.5	2.6	3.3	-1.1	1.6	-1.7	1.7	1.8
Mn content in liver	1.9	2.1	2.5	-1.3	1.3	-1.5	1.5	1.6
Na content in liver	0.0	0.0	0.1	0.3	0.0	0.0	-0.0	-0.2
Rb content in liver	1.2	1.4	2.6	-1.6	1.0	-1.0	1.0	1.1
Se content in liver	6.8	8.0	8.7	-2.6	2.7	-2.9	2.9	2.9
Sr content in liver	0.7	0.6	1.3	-0.2	0.7	-0.7	0.7	1.1
Zn content in liver	0.3	0.3	0.4	0.6	-0.6	0.6	-0.6	-0.3
Bone: minimum diameter	0.3	0.5	1.4	1.2	-0.6	0.6	-0.6	-0.6
Time in familiar zone, hab. session 1	0.4	0.4	0.5	-0.7	0.7	-0.6	0.6	0.3
Time in novel zone, hab. session 1	0.5	0.5	0.8	0.9	-0.9	0.7	-0.7	-0.3
Total zone transitions, hab. session 1	2.5	3.5	4.5	1.8	-1.7	1.9	-1.9	-2.1
Total locomotion distance, hab. session 1	1.2	1.6	2.5	1.3	-1.1	1.2	-1.2	-1.6
Locomotion velocity, hab. session 1	0.9	1.2	2.1	1.1	-0.9	1.0	-1.0	-1.4
Time in familiar zone, hab. session 2	0.1	0.1	0.1	0.2	-0.2	0.2	-0.2	-0.3
Time in novel zone, hab. session 2	0.0	0.0	0.1	-0.1	-0.1	-0.1	0.1	0.3
Total zone transitions, hab. session 2	1.9	2.4	2.6	1.6	-1.5	1.6	-1.6	-1.5
Total locomotion distance, hab. session 2	0.1	0.1	0.2	0.3	-0.1	0.2	-0.2	-0.5
Locomotion velocity, hab. session 2	0.0	0.0	0.1	0.2	0.0	0.1	-0.1	-0.4
Novel to familiar place preference ratio	1.2	1.3	1.4	1.1	-1.1	1.2	-1.2	-1.0
Novelty place preference	1.0	1.1	1.2	1.1	-1.1	1.1	-1.1	-1.0
Time in novel zone, NPP test	0.8	0.8	0.9	0.8	-1.0	1.0	-1.0	-0.8
Total zone transitions, NPP test	0.4	0.6	1.0	-1.0	0.7	-0.7	0.7	0.7
Total locomotion distance, NPP test	0.3	0.5	0.7	-0.7	0.8	-0.7	0.7	0.4
Locomotion velocity, NPP test	0.2	0.3	0.5	-0.5	0.7	-0.5	0.5	0.3
Intraocular pressure	0.0	0.0	0.0	-0.1	-0.0	0.1	-0.1	0.1
Delta distance traveled before/after self-admin	0.2	0.2	0.5	-0.6	0.7	-0.2	0.2	0.4
Delta ambulatory time before/after self-admin	0.1	0.1	0.2	-0.2	0.4	-0.2	0.2	0.4
Parametrial fat weight	0.2	0.6	0.9	0.5	-0.6	0.8	-0.8	-0.9
Pavlov. Cond. lever latency	0.6	0.8	1.0	-0.8	0.7	-1.0	1.0	0.9
Pavlov. Cond. magazine entry latency	1.1	1.4	1.5	1.1	-1.2	1.2	-1.2	-1.2
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	-0.2	0.4	-0.2	0.2	0.4
Pavlov. Cond. index score	0.7	0.9	1.1	0.8	-0.8	1.0	-1.0	-0.9
Pavlov. Cond. latency score	0.7	0.9	1.2	0.9	-0.8	1.1	-1.1	-0.9
Pavlov. Cond. lever contacts	0.5	0.6	0.8	0.8	-0.6	0.9	-0.9	-0.7
Pavlov. Cond. magazine entry number	1.4	1.8	2.0	-1.3	1.3	-1.4	1.4	1.4
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.1	-0.3	0.1	-0.2	0.2	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	1.1	0.8	-0.8	1.0	-1.0	-1.0
Pavlov. Cond. response bias	1.4	1.7	2.0	1.1	-1.2	1.4	-1.4	-1.4
Pavlov. Cond. lever latency	1.9	2.6	3.2	-1.2	1.5	-1.8	1.8	1.6
Pavlov. Cond. magazine entry latency	0.9	1.1	1.8	0.9	-1.3	1.1	-1.1	-0.7
Pavlov. Cond. change in total contacts	0.9	1.5	1.7	1.0	-1.1	1.3	-1.3	-1.2
Pavlov. Cond. index score	1.9	2.5	3.0	1.4	-1.6	1.7	-1.7	-1.4
Pavlov. Cond. latency score	2.3	3.0	3.5	1.5	-1.8	1.9	-1.9	-1.6
Pavlov. Cond. lever contacts	2.4	3.3	4.0	1.5	-1.7	2.0	-2.0	-1.8
Pavlov. Cond. magazine entry number	0.8	1.0	1.5	-0.9	1.2	-1.1	1.1	0.7
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.4	-0.6	0.6	-0.5	0.5	0.2
Pavlov. Cond. lever-magazine prob. diff.	1.4	1.9	2.2	1.2	-1.4	1.5	-1.5	-1.2
Pavlov. Cond. response bias	2.1	2.8	3.5	1.3	-1.7	1.9	-1.9	-1.6
Time in closed arm before self-admin	0.8	1.1	2.1	1.0	-1.4	0.9	-0.9	-0.9
Time in closed arm after self-admin	0.2	0.2	0.3	0.4	-0.5	0.5	-0.5	-0.3
Time in open arm before self-admin	2.9	3.1	5.0	-1.9	2.2	-1.6	1.6	1.3
Time in open arm after self-admin	0.9	0.9	1.2	-0.9	1.1	-1.0	1.0	0.9
Bone: periosteal estimation	0.1	0.2	0.3	-0.1	0.5	-0.5	0.5	0.5
Bone: periosteal perimeter	0.9	1.6	2.3	1.5	-1.3	1.1	-1.1	-1.2
Bone: post-yield work	0.0	0.0	0.1	0.1	-0.1	0.1	-0.1	-0.2
Progressive ratio test 1 active lever presses	2.4	3.0	3.7	1.9	-1.8	1.6	-1.6	-1.6
Progressive ratio test 1 breakpoint	2.4	2.9	3.6	1.9	-1.8	1.6	-1.6	-1.6
Progressive ratio test 1 inactive lever presses	1.2	1.7	2.1	1.5	-1.2	1.3	-1.3	-1.3
Progressive ratio test 2 active lever presses	6.3	7.4	9.0	2.7	-3.0	2.7	-2.7	-2.5
Progressive ratio test 2 breakpoint	6.8	7.7	9.3	2.7	-3.0	2.8	-2.8	-2.6
Progressive ratio test 2 inactive lever presses	2.9	4.6	5.6	2.4	-2.3	2.1	-2.1	-1.9
Incentive Sensitization - Responses	5.3	7.5	9.1	2.4	-3.0	2.8	-2.8	-2.5
Incentive Sensitization - Breakpoint	5.5	7.1	8.7	2.4	-2.9	2.8	-2.8	-2.5
Sum of active levers in priming session hrs 5-6	0.7	0.7	0.8	-0.7	0.8	-0.9	0.9	0.9
Progressive ratio	0.3	0.5	0.7	0.8	-0.9	0.5	-0.5	-0.6
Food seeking constrained by brief footshock	0.9	1.1	1.5	0.9	-1.0	1.2	-1.2	-0.9
Seeking ratio, punishment vs. effort	0.0	0.1	0.1	-0.3	0.4	-0.0	0.0	0.1
Retroperitoneal fat weight	10.1	43.2	50.7	7.1	-6.4	6.5	-6.5	-6.2
Reaction time number correct	0.1	0.1	0.2	-0.5	0.2	0.2	-0.2	-0.4
Reaction time mean minus median	0.5	1.3	1.9	0.7	-1.4	1.1	-1.1	-1.3
Reaction time mean minus median AUC	0.4	1.0	1.4	0.7	-1.1	1.0	-1.0	-1.2
Reaction time num false alarms	1.5	2.1	2.3	-1.4	1.5	-1.5	1.5	1.4
Reaction time num false alarms AUC	2.2	3.4	3.9	-1.8	2.0	-1.8	1.8	1.7
Reaction time trials correct on left	0.1	0.1	0.2	-0.5	0.2	0.2	-0.2	-0.4
Reaction time trials on left	0.1	0.1	0.3	-0.5	0.3	0.2	-0.2	-0.3
Reaction time mean	0.2	0.3	0.9	0.6	-1.0	0.3	-0.3	-0.1
Reaction time mean AUC	0.2	0.4	1.1	0.8	-1.0	0.3	-0.3	-0.2
Median of all reaction times	0.2	0.3	0.8	0.7	-0.9	0.1	-0.1	0.1
Reaction time omissions	0.5	0.7	1.0	-1.0	1.0	-0.8	0.8	0.8
Reaction time false alarm rate	2.6	3.6	4.0	-1.6	1.9	-2.0	2.0	1.9
Reaction time premature initiation rate	0.1	0.2	0.5	-0.6	0.7	0.1	-0.1	-0.0
Reaction time premature initiations	0.2	0.3	0.7	-0.8	0.7	0.2	-0.2	-0.2
Std. dev. reaction times	0.1	0.2	0.5	0.3	-0.7	0.3	-0.3	-0.4
Reaction time trials completed	0.1	0.1	0.3	-0.5	0.3	0.2	-0.2	-0.3
Reaction time trials AUC	0.1	0.1	0.2	-0.4	0.1	0.4	-0.4	-0.5
Run reversals in cocaine runway, females	0.1	0.1	0.2	0.4	-0.4	-0.2	0.2	0.1
Run reversals in cocaine runway, males	3.0	3.0	3.6	-1.9	1.8	-1.8	1.8	1.4
Latency to leave start box in cocaine runway	0.1	0.1	0.1	-0.3	0.2	-0.3	0.3	0.3
Latency to leave start box in cocaine runway, F	0.2	0.3	0.3	0.3	-0.5	0.6	-0.6	-0.5
Latency to leave start box in cocaine runway, M	1.1	1.0	1.3	-0.8	1.0	-1.0	1.0	1.2
Std. dev. time between licks in bursts	0.6	0.8	1.0	-0.8	0.9	-1.0	1.0	0.8
Total sessions with >9 infusions	1.6	1.9	2.6	1.6	-1.3	1.3	-1.3	-1.3
Short access day 1 total inactive lever presses	0.9	1.2	1.4	1.0	-1.1	1.1	-1.1	-1.2
Short access day 10 total inactive lever presses	0.1	0.3	0.4	0.5	-0.3	0.7	-0.7	-0.5
Short access day 1 total infusions	2.0	2.7	3.7	1.9	-1.7	1.6	-1.6	-1.4
Short access day 10 total infusions	2.2	2.8	4.5	2.1	-1.6	1.5	-1.5	-1.5
Short access total infusions	2.4	3.1	4.7	2.2	-1.8	1.6	-1.6	-1.6
Short access day 1 locomotion	1.3	1.6	3.5	1.9	-1.1	1.0	-1.0	-1.2
Short access day 10 total locomotion	2.4	4.4	6.7	2.6	-1.9	2.0	-2.0	-1.8
Short access total locomotion	2.6	3.1	5.2	2.3	-1.6	1.6	-1.6	-1.6
One hour access (0.3 mA shock)	5.5	6.3	8.1	2.9	-2.7	2.3	-2.3	-2.3
Compulsive drug intake	2.0	2.3	3.3	-1.8	1.5	-1.4	1.4	1.4
One hour access (shock baseline)	5.5	8.4	10.4	3.2	-3.1	2.8	-2.8	-2.6
Social response proportion	4.6	5.3	5.5	-2.3	2.2	-2.3	2.3	2.3
Social responses	0.1	0.1	0.3	0.3	-0.3	0.2	-0.2	-0.5
Social time	1.3	1.8	3.1	-1.8	1.1	-1.2	1.2	1.2
Soleus weight	1.3	3.7	4.6	-1.8	2.1	-2.0	2.0	1.7
Bone: stiffness	0.5	0.8	1.3	1.2	-1.0	0.7	-0.7	-0.8
Tibialis anterior weight	2.9	9.7	11.6	-3.3	3.4	-3.0	3.0	2.8
Time to tail flick, vehicle, before self-admin	3.3	3.4	4.5	1.9	-2.1	1.7	-1.7	-1.8
Time to tail flick, vehicle, after self-admin	3.7	4.8	5.7	2.2	-2.4	2.2	-2.2	-2.1
Time to tail flick, test, before self-admin	0.9	0.9	1.5	1.2	-1.1	0.9	-0.9	-0.6
Time to tail flick, test, after self-admin	2.6	2.6	3.3	1.8	-1.7	1.7	-1.7	-1.3
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.0	-0.1	-0.0	0.2	-0.2	0.0
Delta time to tail flick, test, before/after SA	0.0	0.0	0.1	0.2	-0.1	0.2	-0.2	-0.3
Tibia length	0.3	0.7	1.2	-0.9	1.1	-0.8	0.8	0.7
Ambulatory time before self-admin	0.1	0.2	0.3	-0.1	0.4	-0.5	0.5	0.5
Ambulatory time after self-admin	0.0	0.0	0.1	0.3	0.1	-0.0	0.0	0.2
Bone: tissue strength	0.1	0.1	0.2	0.1	-0.2	0.3	-0.3	-0.4
Total heroin consumption	1.3	1.6	2.2	-1.0	1.1	-1.5	1.5	1.2
Bone: trabecular number	0.4	0.6	0.7	0.8	-0.7	0.8	-0.8	-0.8
Bone: trabecular spacing	0.3	0.4	0.7	0.5	-0.8	0.8	-0.8	-0.4
Bone: trabecular thickness	0.5	0.7	0.8	0.8	-0.6	0.9	-0.9	-0.8
Bone: trabecular tissue density	0.7	1.0	1.3	-0.8	0.9	-1.1	1.1	0.9
Water consumed over 24 hours	0.1	0.2	0.4	0.7	-0.5	0.3	-0.3	-0.2
Number of responses in last shaping day	2.5	2.7	3.2	1.7	-1.8	1.6	-1.6	-1.5