Hub : Genes

Ces2c

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 OFC gene expression Ces2c 0.29 0.15 6.8e-07 0.3 0.28 0.28 0.2 5.7e-08 1.8e-07 2.2e-07 1.8e-05
2 pVTA gene expression Ces2c 0.34 0.14 0.0e+00 0.35 0.35 0.34 0.35 2.5e-29 7.2e-29 5.0e-28 7.1e-29
3 Liver mRNA stability Ces2c 0.02 0.01 6.5e-03 0.01 0.01 0.01 0.01 7.1e-03 1.4e-02 7.1e-02 3.0e-02
4 Brain gene expression Ces2c 0.23 0.12 0.0e+00 0.27 0.27 0.27 0.26 2.7e-25 6.1e-25 8.8e-25 1.2e-24
5 PL gene expression Ces2c 0.64 0.02 0.0e+00 0.37 0.36 0.37 0.37 2.0e-42 1.8e-41 1.8e-42 6.7e-43
6 BLA gene expression Ces2c 0.25 0.13 4.0e-12 0.17 0.16 0.16 0.16 2.6e-09 4.7e-09 8.4e-09 7.4e-09
7 IL gene expression Ces2c 0.38 0.17 1.0e-08 0.3 0.26 0.23 0.27 5.3e-08 6.3e-07 3.7e-06 3.0e-07
8 IC gene expression Ces2c 0.26 0.14 6.7e-10 0.22 0.21 0.21 0.21 1.9e-09 4.5e-09 2.4e-09 3.8e-09
9 NAcc gene expression Ces2c 0.15 0.07 0.0e+00 0.17 0.21 0.21 0.21 1.1e-25 2.6e-31 1.0e-31 1.3e-31
10 LHb gene expression Ces2c 0.26 0.15 6.2e-05 0.14 0.18 0.21 0.15 3.8e-04 4.1e-05 1.2e-05 2.1e-04
11 Adipose gene expression Ces2c 0.12 0.08 4.0e-08 0.06 0.07 0.07 0.06 6.7e-07 8.5e-08 4.0e-08 2.1e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density1.32.43.0-1.5-1.61.7-1.71.6-1.6-1.6-1.6-1.3-1.1-1.7
Area under the delay curve0.40.60.8-0.6-0.70.9-0.90.9-0.7-0.7-0.6-0.6-0.8-0.8
BMI with tail26.492.298.7-9.9-9.99.9-9.99.9-9.9-9.9-9.9-9.6-9.0-7.6
BMI without tail11.259.864.0-8.0-7.98.0-7.97.9-8.0-8.0-8.0-7.7-7.3-6.0
Body weight22.397.5106.3-10.3-10.210.2-10.110.2-10.2-10.2-10.2-9.6-8.9-8.4
Weight adjusted by age2.47.18.5-2.9-2.82.7-2.92.9-2.6-2.6-2.6-2.8-2.5-1.7
Bone surface1.32.53.0-1.6-1.61.7-1.61.6-1.7-1.7-1.6-1.4-1.2-1.6
Bone volume3.16.16.9-2.5-2.52.6-2.52.5-2.6-2.6-2.6-2.4-2.2-2.1
Breakpoint value in progressive ratio session3.05.56.8-2.2-2.52.4-2.32.5-2.6-2.6-2.5-2.1-1.8-2.3
Number of licking bursts0.10.21.3-0.2-0.30.3-0.30.2-0.4-0.4-0.40.10.3-1.2
Context. condit. distance diff. score0.20.20.30.50.4-0.50.5-0.40.50.50.40.50.50.1
Locomotion velocity, session 11.41.61.81.31.3-1.31.3-1.31.31.31.31.31.40.7
Locomotion distance, session 12.73.44.01.91.9-1.91.9-1.91.91.92.01.61.51.9
Locomotion velocity, session 21.11.42.01.21.3-1.21.2-1.21.21.21.30.90.71.4
Locomotion distance, session 20.10.20.6-0.2-0.20.2-0.20.2-0.3-0.3-0.2-0.6-0.80.6
Locomotion velocity, session 32.93.33.91.91.9-1.81.8-1.82.02.02.01.81.61.4
Locomotion distance, session 31.41.62.01.41.3-1.31.3-1.31.31.31.31.11.01.1
Stereotopy head waving bouts, day 30.30.40.90.60.5-0.60.5-0.50.70.70.60.40.31.0
Stereotopy head waving duration, day 30.10.10.30.20.2-0.20.2-0.20.40.40.30.10.10.6
Locomotion velocity, session 70.10.10.20.30.4-0.40.3-0.30.40.40.30.40.5-0.0
Locomotion distance, session 70.00.00.1-0.1-0.10.1-0.10.1-0.1-0.1-0.1-0.3-0.30.2
Stereotopy head waving bouts, day 70.20.20.8-0.4-0.50.4-0.40.4-0.5-0.5-0.5-0.00.2-0.9
Stereotopy head waving duration, day 70.20.21.1-0.0-0.10.1-0.10.1-0.1-0.10.00.60.8-1.0
Locomotion velocity, session 82.83.44.51.81.9-1.81.9-1.91.91.92.02.12.00.9
Locomotion distance, session 81.21.72.11.41.3-1.41.4-1.41.31.31.31.31.21.1
Degree of sensitization distance1.51.62.3-1.5-1.41.3-1.41.4-1.3-1.3-1.2-1.3-1.2-0.9
Degree of sensitization stereotypy0.70.82.4-0.7-0.90.8-0.80.8-1.0-1.0-0.9-0.30.1-1.6
Conditioned locomotion0.00.00.10.0-0.10.1-0.00.1-0.3-0.3-0.3-0.1-0.0-0.2
Cocaine response after cond. corrected3.65.411.22.32.3-2.32.3-2.32.42.42.41.50.93.3
Cocaine response after cond. not corrected4.66.79.92.62.7-2.72.6-2.62.72.72.72.01.63.2
Cocaine response before conditioning0.20.31.40.00.2-0.20.2-0.20.20.20.10.81.2-1.0
Saline control response0.20.31.30.50.4-0.50.5-0.40.70.70.60.0-0.21.1
Bone: connectivity density0.00.00.10.10.10.1-0.0-0.0-0.0-0.00.00.20.3-0.3
Bone: cortical apparent density8.313.115.03.73.7-3.93.8-3.73.73.73.73.22.93.7
Bone: cortical area11.218.220.2-4.5-4.54.5-4.54.4-4.4-4.4-4.3-4.2-3.9-3.5
Bone: cortical porosity0.30.40.7-0.7-0.60.7-0.70.6-0.6-0.6-0.5-0.4-0.3-0.8
Bone: cortical porosity1.81.92.8-1.5-1.51.5-1.61.4-1.4-1.4-1.3-1.1-0.9-1.7
Bone: cortical thickness6.711.112.8-3.6-3.53.4-3.53.4-3.3-3.3-3.2-3.5-3.4-2.2
Bone: cortical thickness6.88.311.4-3.0-2.92.9-2.92.8-2.9-2.9-2.9-3.3-3.4-1.2
Bone: cortical tissue density9.214.616.64.03.9-4.14.0-3.93.93.93.93.43.13.8
Condit. Reinf. active minus inactive responses2.52.93.51.71.7-1.71.7-1.71.81.81.81.91.90.9
Condit. Reinf. active-inactive response ratio2.42.63.61.51.6-1.61.6-1.61.71.71.61.81.90.8
Condit. Reinf. active responses0.20.30.40.50.5-0.50.5-0.50.60.60.50.60.60.1
Condit. Reinf. inactive responses0.81.11.2-1.0-1.11.0-1.11.1-1.0-1.0-1.0-1.1-1.0-1.0
Incentive salience index mean1.72.22.51.51.5-1.51.5-1.51.61.61.51.51.51.0
Condit. Reinf. lever presses0.91.31.61.21.3-1.21.3-1.31.21.21.11.00.91.0
Condit. Reinf. active minus inactive responses1.52.44.3-1.5-1.61.5-1.61.6-1.6-1.6-1.6-1.1-0.7-2.1
Condit. Reinf. active-inactive response ratio2.33.64.8-1.9-1.91.9-1.91.9-2.1-2.1-2.1-1.6-1.2-2.2
Condit. Reinf. active responses1.92.75.2-1.7-1.71.6-1.71.7-1.7-1.7-1.7-1.1-0.7-2.3
Condit. Reinf. inactive responses0.50.71.6-1.0-0.90.9-1.00.9-0.7-0.7-0.6-0.4-0.3-1.3
Condit. Reinf. lever presses1.31.92.3-1.5-1.51.4-1.51.5-1.3-1.3-1.3-1.3-1.1-1.4
Condit. Reinf. lever reinforcers received0.91.33.2-1.2-1.21.1-1.21.2-1.2-1.2-1.1-0.7-0.3-1.8
Conditioned reinforcement - actives0.51.82.41.51.5-1.51.5-1.51.21.21.21.21.11.3
Conditioned reinforcement - inactives0.41.01.41.11.0-1.11.2-1.20.80.80.91.01.20.5
Conditioned locomotion2.33.44.22.01.9-2.02.0-2.01.81.81.61.51.51.8
Patch foraging indifference point 0 sec2.98.09.2-2.9-3.03.0-3.03.0-2.8-2.8-2.7-2.9-2.9-1.9
Patch foraging indifference point AUC0.00.10.2-0.3-0.40.3-0.20.3-0.4-0.4-0.3-0.5-0.4-0.1
Delay disc. indifference point, 0s delay0.50.50.9-0.9-1.00.8-0.90.9-0.5-0.5-0.2-0.7-1.0-0.2
Delay disc. indifference point, 16s delay0.30.41.2-0.5-0.60.7-0.70.7-0.6-0.6-0.6-0.2-0.3-1.1
Delay disc. indifference point, 2s delay0.00.00.30.10.10.2-0.10.1-0.0-0.00.1-0.2-0.50.4
Delay disc. indifference point, 24s delay0.50.71.0-0.8-0.91.0-1.01.0-0.8-0.8-0.7-0.7-0.9-0.8
Delay disc. indifference point, 4s delay0.30.30.5-0.5-0.60.7-0.60.6-0.5-0.5-0.3-0.4-0.7-0.7
Delay disc. indifference point, 8s delay0.00.00.1-0.1-0.20.3-0.30.3-0.1-0.1-0.1-0.2-0.3-0.1
Indifference point function ln k0.00.10.3-0.5-0.40.3-0.40.4-0.2-0.2-0.2-0.4-0.60.1
Indifference point function log k0.00.10.3-0.5-0.40.3-0.40.4-0.2-0.2-0.2-0.4-0.60.1
Patch foraging total patch changes 0 sec3.510.311.7-3.3-3.43.4-3.43.4-3.2-3.2-3.1-3.3-3.3-2.2
Patch foraging total patch changes 12 sec3.54.75.4-2.1-2.32.2-2.32.3-2.2-2.2-2.1-2.3-2.2-1.5
Patch foraging total patch changes 18 sec1.22.83.3-1.7-1.81.7-1.71.7-1.7-1.7-1.7-1.8-1.7-1.2
Patch foraging total patch changes 24 sec0.20.50.8-0.6-0.90.8-0.80.9-0.7-0.7-0.6-0.8-0.8-0.4
Patch foraging total patch changes 6 sec3.76.37.2-2.6-2.72.7-2.62.6-2.5-2.5-2.4-2.6-2.6-1.6
Patch foraging time to switch 0 sec0.51.82.61.61.5-1.31.3-1.41.31.31.21.51.40.8
Patch foraging water rate 0 sec1.24.45.2-2.2-2.22.1-2.22.2-2.1-2.1-2.0-2.3-2.3-1.3
Patch foraging water rate 12 sec1.35.36.0-2.3-2.52.3-2.42.4-2.4-2.4-2.3-2.2-2.1-2.0
Patch foraging water rate 18 sec0.71.63.2-1.4-1.41.1-1.21.2-1.1-1.1-1.0-1.6-1.8-0.0
Patch foraging water rate 24 sec3.34.78.9-2.3-2.32.2-2.12.2-1.9-1.9-1.9-2.7-3.0-0.4
Patch foraging water rate 6 sec1.92.84.8-1.9-1.81.7-1.81.7-1.5-1.5-1.4-2.0-2.2-0.5
Seeking ratio, delayed vs. immediate footshock8.011.515.13.93.8-3.33.5-3.63.43.43.43.32.92.5
Distance traveled before self-admin0.81.74.81.51.3-1.21.2-1.21.41.41.40.70.32.2
Distance traveled after self-admin1.93.35.01.81.8-1.81.8-1.72.02.02.11.51.02.2
Extensor digitorum longus weight1.97.68.4-2.8-2.82.9-2.82.8-2.8-2.8-2.8-2.8-2.7-2.1
Bone: elastic displacement0.30.30.9-0.6-0.50.6-0.60.5-0.5-0.5-0.5-0.8-0.90.0
Bone: elastic work2.63.46.4-1.8-1.71.9-1.91.7-1.7-1.7-1.7-2.3-2.5-0.3
Bone: endosteal estimation1.64.05.0-1.9-2.02.1-2.02.0-2.2-2.2-2.2-1.9-1.6-1.9
Bone: endosteal perimeter3.38.19.1-2.9-2.93.0-2.92.9-3.0-3.0-3.0-2.7-2.4-2.6
Epididymis fat weight17.588.496.1-9.8-9.89.7-9.79.7-9.7-9.7-9.7-8.7-7.9-8.9
Delta time in closed arm before/after self-admin0.20.10.90.40.4-0.40.3-0.30.20.2-0.0-0.2-0.20.9
Delta time in open arm before/after self-admin1.21.56.0-1.3-1.31.2-1.21.2-1.0-1.0-0.7-0.20.0-2.4
Diff in mean of infusions in LGA sessions0.91.62.3-1.3-1.41.2-1.31.4-1.3-1.3-1.5-1.2-0.7-1.2
Delay discount exponential model param0.40.60.90.60.7-0.90.9-0.90.80.80.70.60.90.7
Extinction: sum of active levers before priming0.40.61.2-0.8-0.80.7-0.70.8-0.9-0.9-0.8-0.6-0.3-1.1
Active lever presses in extinction session 64.04.05.0-2.1-2.21.9-2.02.1-2.1-2.1-2.1-2.2-1.8-1.2
Bone: final force7.812.714.4-3.7-3.73.8-3.83.7-3.5-3.5-3.5-3.6-3.6-2.3
Bone: final moment8.213.315.0-3.8-3.83.9-3.93.8-3.6-3.6-3.6-3.7-3.6-2.5
Food consumed during 24 hour testing period0.20.40.6-0.6-0.60.6-0.60.6-0.7-0.7-0.7-0.8-0.7-0.4
Glucose9.314.716.9-3.9-4.14.0-4.14.1-3.9-3.9-3.8-3.3-2.9-4.0
Heart weight14.523.326.3-4.9-4.85.1-5.15.0-5.1-5.1-5.0-4.4-4.1-4.3
Delay discount hyperbolic model param0.50.60.90.60.7-0.90.9-0.90.80.80.70.70.90.7
Intermittent access intake day 1-15 change0.00.10.40.20.1-0.30.2-0.20.30.30.40.1-0.00.7
Intermittent access intake escalation0.00.00.10.1-0.1-0.10.1-0.10.10.10.2-0.00.00.3
Intermittent access intake escalation 20.10.20.4-0.5-0.60.3-0.60.6-0.4-0.4-0.2-0.5-0.4-0.1
Intermitt. access day 1 inactive lever presses0.11.22.1-1.2-1.21.1-1.11.1-1.2-1.2-1.0-0.8-0.5-1.4
Intermitt. access day 15 inactive lever presses0.41.92.5-1.5-1.51.3-1.31.4-1.6-1.6-1.3-1.5-1.3-0.9
Intermitt. access escalation Index0.20.50.90.60.5-0.70.6-0.60.80.80.90.80.80.3
Intermittent access day 1 total infusions0.10.30.50.70.6-0.60.7-0.70.40.40.40.40.30.6
Intermittent access day 15 total infusions0.10.20.50.40.4-0.50.5-0.50.30.30.40.20.20.7
Intermittent access terminal intake (last 3 days)0.00.00.20.20.2-0.20.1-0.2-0.1-0.10.0-0.0-0.10.4
Intermittent access total infusions0.40.50.80.80.8-0.80.9-0.90.40.40.50.50.50.8
Intermittent access day 1 locomotion0.81.42.51.21.3-1.41.4-1.31.11.11.00.80.71.6
Intermittent access day 15 total locomotion0.00.00.10.10.2-0.30.3-0.30.10.10.00.10.20.1
Intermittent access total locomotion1.11.32.41.21.2-1.31.2-1.31.01.01.00.70.71.6
Intermittent access standard deviation0.10.50.7-0.6-0.80.8-0.70.7-0.8-0.8-0.7-0.7-0.8-0.5
Left kidney weight5.544.450.6-6.6-6.76.8-6.76.8-7.0-7.0-6.9-7.1-6.9-4.4
Right kidney weight7.250.661.2-7.0-7.17.3-7.27.2-7.3-7.3-7.3-7.7-7.8-4.1
Cocaine induced anxiety0.82.33.61.81.6-1.61.6-1.61.41.41.41.11.01.9
Post-drug Anxiety0.00.00.10.1-0.0-0.10.1-0.10.00.00.00.20.3-0.3
Baseline Anxiety1.42.36.2-1.9-1.61.5-1.51.5-1.3-1.3-1.4-0.8-0.4-2.5
Tail length0.31.42.2-1.3-1.11.1-1.11.1-1.3-1.3-1.2-0.9-0.7-1.5
Length with tail1.98.59.9-3.2-3.03.0-2.93.0-3.0-3.0-2.9-2.6-2.3-3.1
Length without tail2.512.915.9-3.8-3.83.7-3.73.7-3.7-3.7-3.6-3.0-2.6-4.0
Times rat made contact with spout1.41.71.9-1.2-1.41.3-1.41.4-1.3-1.3-1.3-1.3-1.1-1.1
Lifetime Intake0.50.61.01.01.0-0.91.0-1.00.50.50.50.50.40.9
Liver weight, left10.418.019.9-4.4-4.54.4-4.44.4-4.3-4.3-4.3-4.2-4.0-3.4
Liver weight, right3.05.36.2-2.5-2.52.5-2.32.4-2.2-2.2-2.1-2.4-2.4-1.6
Locomotor activity0.20.30.60.20.2-0.50.2-0.20.80.80.80.60.60.3
Locomotor testing distance0.51.32.41.01.0-1.10.9-0.91.51.51.51.00.71.4
Locomotor testing rearing0.00.20.5-0.3-0.50.4-0.50.50.10.10.2-0.4-0.70.4
Locomotion in novel chamber0.30.41.3-0.2-0.30.4-0.20.3-0.6-0.6-0.4-0.9-1.10.9
Locomotion in novel chamber post-restriction0.10.21.7-0.00.0-0.1-0.00.00.00.0-0.0-0.6-0.81.3
Fecal boli incidents, locomotor time 10.30.71.8-0.6-0.80.7-0.70.8-0.9-0.9-1.1-0.5-0.3-1.3
Change in fecal boli incidents, locomotor task0.20.20.3-0.5-0.50.3-0.30.4-0.4-0.4-0.3-0.6-0.50.1
Time >=10cm from walls, locomotor time 10.10.10.30.30.2-0.30.4-0.30.50.50.40.50.4-0.0
Bouts of movement, locomotor time 10.20.30.6-0.6-0.60.6-0.70.6-0.4-0.4-0.4-0.2-0.3-0.8
Total resting periods, locomotor time 10.30.30.5-0.6-0.60.7-0.70.6-0.4-0.4-0.4-0.4-0.5-0.5
Rest time, locomotor task time 10.61.02.4-0.9-0.81.0-0.90.8-1.0-1.0-1.0-1.3-1.50.3
Distance moved, locomotor task time 10.10.20.40.30.3-0.50.4-0.30.60.60.70.60.60.1
Vertical activity count, locomotor time 10.10.91.20.80.9-0.90.9-0.81.11.11.00.90.90.7
Time >=10cm from walls, locomotor time 20.00.10.3-0.2-0.40.3-0.30.3-0.1-0.1-0.1-0.3-0.50.2
Bouts of movement, locomotor time 20.00.00.10.20.1-0.00.0-0.1-0.0-0.00.10.0-0.10.2
Total resting periods, locomotor time 20.00.00.10.30.1-0.10.1-0.10.10.10.20.10.00.3
Rest time, locomotor task time 20.10.10.40.10.2-0.10.1-0.20.40.40.60.30.10.4
Distance moved, locomotor task time 20.00.00.20.20.3-0.20.1-0.10.10.10.1-0.0-0.00.5
Vertical activity count, locomotor time 20.10.20.30.50.5-0.50.5-0.50.50.50.30.40.40.6
Light reinforcement 10.10.51.90.60.7-0.60.5-0.60.50.50.70.0-0.31.4
Light reinforcement 20.10.30.50.70.7-0.50.6-0.70.30.30.40.60.60.2
Bone: marrow area1.84.55.5-2.1-2.12.2-2.22.1-2.3-2.3-2.3-2.0-1.7-1.9
Bone: maximum diameter5.911.813.1-3.6-3.53.6-3.53.5-3.6-3.6-3.6-3.0-2.6-3.6
Bone: maximum force4.89.510.8-3.2-3.23.3-3.33.2-3.1-3.1-3.1-3.1-3.1-2.1
Bone: maximum moment5.19.711.1-3.2-3.23.3-3.33.3-3.1-3.1-3.1-3.1-3.0-2.2
Mean time between licks in bursts0.10.72.10.70.7-0.70.6-0.70.60.60.61.21.4-0.3
Mean num. licks in bursts0.10.41.2-0.4-0.50.4-0.50.5-0.4-0.4-0.4-0.9-1.10.7
Cd content in liver0.20.21.30.10.00.00.0-0.00.00.00.2-0.6-0.91.2
Co content in liver0.30.31.4-0.3-0.30.3-0.30.3-0.3-0.3-0.2-0.8-1.20.9
Cu content in liver0.20.20.4-0.3-0.40.5-0.30.3-0.6-0.6-0.6-0.6-0.6-0.1
Fe content in liver0.30.41.8-0.6-0.50.5-0.40.4-0.7-0.7-0.7-0.10.3-1.4
K content in liver0.30.20.4-0.4-0.40.5-0.40.4-0.6-0.6-0.6-0.5-0.6-0.3
Mg content in liver0.90.92.1-0.8-0.91.0-0.90.9-1.0-1.0-0.9-1.3-1.50.0
Mn content in liver0.80.91.8-0.9-0.91.0-1.00.9-0.9-0.9-0.8-1.1-1.3-0.1
Na content in liver2.73.03.7-1.7-1.71.9-1.71.7-1.8-1.8-1.9-1.7-1.7-1.4
Rb content in liver0.20.20.3-0.4-0.50.5-0.50.5-0.4-0.4-0.4-0.4-0.4-0.5
Se content in liver0.00.00.10.20.3-0.20.3-0.30.10.10.00.20.20.2
Sr content in liver2.52.26.21.51.5-1.51.2-1.21.51.51.61.00.62.5
Zn content in liver0.20.31.60.40.3-0.20.4-0.40.20.20.3-0.3-0.61.3
Bone: minimum diameter6.512.413.9-3.6-3.73.7-3.73.6-3.6-3.6-3.6-3.2-2.8-3.4
Time in familiar zone, hab. session 12.42.73.1-1.8-1.71.7-1.71.7-1.7-1.7-1.6-1.5-1.4-1.4
Time in novel zone, hab. session 14.24.76.52.22.2-2.32.2-2.22.22.22.22.42.61.0
Total zone transitions, hab. session 10.00.10.3-0.00.1-0.10.1-0.10.10.10.1-0.3-0.40.6
Total locomotion distance, hab. session 10.20.20.60.40.4-0.50.4-0.40.50.50.50.60.7-0.0
Locomotion velocity, hab. session 10.10.10.20.20.3-0.30.3-0.30.40.40.30.40.50.0
Time in familiar zone, hab. session 20.60.72.50.50.5-0.60.5-0.50.70.70.71.41.6-0.8
Time in novel zone, hab. session 20.40.41.1-0.5-0.40.5-0.50.5-0.7-0.7-0.7-1.0-1.00.3
Total zone transitions, hab. session 20.10.10.3-0.3-0.20.2-0.30.3-0.2-0.2-0.2-0.5-0.50.3
Total locomotion distance, hab. session 20.40.50.6-0.7-0.70.7-0.80.7-0.8-0.8-0.7-0.6-0.5-0.6
Locomotion velocity, hab. session 20.60.80.9-0.9-0.90.9-1.00.9-0.9-0.9-0.9-0.9-0.8-0.6
Novel to familiar place preference ratio0.20.30.90.30.4-0.40.4-0.30.40.40.40.91.0-0.4
Novelty place preference0.20.31.00.30.4-0.40.4-0.40.40.40.40.91.0-0.3
Time in novel zone, NPP test0.30.41.50.20.3-0.20.2-0.20.30.30.31.01.2-0.9
Total zone transitions, NPP test0.10.20.7-0.3-0.30.3-0.30.3-0.4-0.4-0.3-0.8-0.80.4
Total locomotion distance, NPP test0.00.00.1-0.0-0.10.0-0.10.1-0.1-0.1-0.1-0.3-0.30.3
Locomotion velocity, NPP test0.10.21.30.20.1-0.20.1-0.10.00.00.1-0.5-0.71.1
Intraocular pressure0.10.20.90.10.0-0.00.1-0.10.00.00.10.60.7-0.9
Delta distance traveled before/after self-admin0.40.50.70.40.6-0.80.7-0.70.70.70.80.70.60.5
Delta ambulatory time before/after self-admin0.20.40.60.40.6-0.70.7-0.60.70.70.80.60.60.4
Parametrial fat weight30.371.377.9-8.8-8.78.8-8.88.7-8.6-8.6-8.6-8.1-7.6-7.2
Pavlov. Cond. lever latency0.20.30.50.60.6-0.50.5-0.50.50.50.70.70.60.3
Pavlov. Cond. magazine entry latency0.30.40.7-0.6-0.70.6-0.60.6-0.6-0.6-0.7-0.5-0.4-0.8
Pavlov. Cond. change in total contacts1.92.03.6-1.4-1.61.5-1.51.5-1.4-1.4-1.5-1.0-0.7-1.9
Pavlov. Cond. index score0.81.01.3-0.9-1.01.0-1.01.0-1.0-1.0-1.1-0.9-0.8-1.1
Pavlov. Cond. latency score0.60.81.0-0.8-0.90.9-0.80.8-0.9-0.9-1.0-0.8-0.7-0.9
Pavlov. Cond. lever contacts0.91.11.5-1.0-1.11.1-1.01.0-1.1-1.1-1.2-1.0-0.9-1.0
Pavlov. Cond. magazine entry number0.70.81.10.81.0-0.90.9-0.90.90.91.00.80.71.0
Pavlov. Cond. intertrial magazine entries1.01.21.7-1.1-1.11.1-1.11.1-1.1-1.1-1.0-1.2-1.3-0.4
Pavlov. Cond. lever-magazine prob. diff.0.81.01.5-0.9-1.11.0-1.01.0-1.0-1.0-1.1-0.9-0.8-1.2
Pavlov. Cond. response bias0.40.50.6-0.7-0.80.7-0.70.7-0.7-0.7-0.8-0.7-0.6-0.7
Pavlov. Cond. lever latency0.50.71.90.90.9-0.80.8-0.80.90.90.80.50.31.4
Pavlov. Cond. magazine entry latency0.30.41.40.20.4-0.50.4-0.40.40.40.51.01.2-0.6
Pavlov. Cond. change in total contacts0.10.31.0-0.5-0.60.5-0.50.5-0.7-0.7-0.6-0.2-0.0-1.0
Pavlov. Cond. index score0.10.10.8-0.3-0.30.2-0.20.2-0.2-0.2-0.10.20.4-0.9
Pavlov. Cond. latency score0.10.10.6-0.3-0.30.2-0.20.2-0.2-0.2-0.20.10.2-0.8
Pavlov. Cond. lever contacts0.40.51.2-0.8-0.80.7-0.70.7-0.7-0.7-0.7-0.5-0.4-1.1
Pavlov. Cond. magazine entry number0.10.10.6-0.1-0.20.3-0.20.3-0.3-0.3-0.3-0.6-0.70.4
Pavlov. Cond. intertrial magazine entries1.94.27.0-2.0-2.12.1-2.12.1-2.0-2.0-1.9-2.5-2.6-0.6
Pavlov. Cond. lever-magazine prob. diff.0.00.10.5-0.2-0.10.0-0.10.0-0.1-0.10.00.30.5-0.7
Pavlov. Cond. response bias0.20.31.9-0.5-0.40.4-0.40.4-0.5-0.5-0.40.10.4-1.4
Time in closed arm before self-admin0.10.10.20.20.3-0.30.4-0.30.40.40.50.30.30.1
Time in closed arm after self-admin0.40.51.70.90.8-0.80.7-0.60.50.50.30.00.11.3
Time in open arm before self-admin0.81.01.51.21.2-1.01.0-1.20.90.90.81.00.80.8
Time in open arm after self-admin0.50.53.5-0.6-0.60.6-0.50.5-0.5-0.5-0.30.40.5-1.9
Bone: periosteal estimation6.715.917.4-4.1-4.14.2-4.14.1-4.1-4.1-4.2-3.9-3.6-3.3
Bone: periosteal perimeter10.721.023.1-4.7-4.74.8-4.74.7-4.8-4.8-4.8-4.4-4.0-4.0
Bone: post-yield work0.20.40.8-0.5-0.60.6-0.60.6-0.7-0.7-0.6-0.3-0.2-0.9
Progressive ratio test 1 active lever presses0.50.91.31.11.1-1.01.1-1.10.80.80.80.70.51.1
Progressive ratio test 1 breakpoint0.30.61.00.90.9-0.80.9-0.90.60.60.60.50.41.0
Progressive ratio test 1 inactive lever presses0.10.20.40.60.5-0.40.6-0.60.20.20.40.50.40.3
Progressive ratio test 2 active lever presses0.00.00.30.00.2-0.10.1-0.1-0.1-0.1-0.0-0.2-0.30.5
Progressive ratio test 2 breakpoint0.00.00.20.10.2-0.10.1-0.1-0.2-0.2-0.0-0.2-0.30.5
Progressive ratio test 2 inactive lever presses0.00.10.20.40.3-0.40.4-0.40.20.20.40.30.30.5
Incentive Sensitization - Responses0.20.50.7-0.8-0.70.7-0.70.7-0.8-0.8-0.7-0.7-0.7-0.4
Incentive Sensitization - Breakpoint0.10.30.5-0.6-0.50.5-0.60.6-0.7-0.7-0.5-0.6-0.5-0.3
Sum of active levers in priming session hrs 5-60.30.30.5-0.7-0.70.5-0.50.6-0.6-0.6-0.5-0.6-0.4-0.4
Progressive ratio0.82.43.31.71.7-1.31.6-1.61.61.61.81.41.01.6
Food seeking constrained by brief footshock4.75.97.32.32.4-2.42.6-2.62.52.52.72.52.41.6
Seeking ratio, punishment vs. effort0.10.20.30.20.3-0.50.5-0.50.40.40.30.40.60.1
Retroperitoneal fat weight27.0121.0135.6-11.6-11.411.3-11.311.3-11.3-11.3-11.3-10.5-9.6-9.8
Reaction time number correct0.20.61.2-0.9-0.60.9-0.90.8-0.9-0.9-0.7-0.5-0.5-1.1
Reaction time mean minus median0.00.00.10.0-0.10.1-0.10.10.00.0-0.1-0.2-0.40.3
Reaction time mean minus median AUC0.10.41.3-0.2-0.40.6-0.60.5-0.5-0.5-0.5-0.8-1.10.3
Reaction time num false alarms0.00.10.3-0.10.1-0.20.1-0.20.30.30.40.0-0.10.5
Reaction time num false alarms AUC0.00.10.3-0.5-0.30.3-0.40.3-0.1-0.1-0.1-0.4-0.50.1
Reaction time trials correct on left0.20.61.2-0.9-0.60.9-0.90.8-0.9-0.9-0.7-0.5-0.5-1.1
Reaction time trials on left0.20.61.2-0.9-0.60.9-0.80.8-0.8-0.8-0.7-0.5-0.5-1.1
Reaction time mean0.81.72.31.51.4-1.41.2-1.31.41.41.21.21.11.2
Reaction time mean AUC0.71.72.41.51.4-1.31.2-1.31.31.31.21.10.91.4
Median of all reaction times1.62.63.21.81.7-1.71.5-1.71.61.61.51.51.41.4
Reaction time omissions0.20.30.80.40.5-0.50.4-0.50.60.60.50.80.9-0.2
Reaction time false alarm rate0.00.10.3-0.00.1-0.20.1-0.20.30.30.3-0.0-0.10.5
Reaction time premature initiation rate0.20.30.70.50.3-0.60.5-0.30.60.60.60.20.30.9
Reaction time premature initiations0.00.10.2-0.3-0.30.1-0.20.4-0.1-0.1-0.0-0.3-0.30.1
Std. dev. reaction times0.00.00.00.10.00.0-0.10.00.00.0-0.1-0.1-0.10.1
Reaction time trials completed0.20.61.2-0.9-0.60.9-0.80.8-0.8-0.8-0.7-0.5-0.5-1.1
Reaction time trials AUC0.31.11.6-1.1-0.91.1-1.11.0-1.1-1.1-1.0-0.7-0.7-1.3
Run reversals in cocaine runway, females0.20.20.30.40.4-0.40.3-0.30.50.50.50.60.50.0
Run reversals in cocaine runway, males0.40.42.70.60.6-0.60.5-0.50.50.50.3-0.0-0.21.6
Latency to leave start box in cocaine runway0.20.21.4-0.3-0.30.4-0.40.4-0.3-0.3-0.30.20.3-1.2
Latency to leave start box in cocaine runway, F0.20.21.1-0.6-0.50.4-0.50.5-0.3-0.3-0.20.00.2-1.0
Latency to leave start box in cocaine runway, M0.30.30.6-0.3-0.40.7-0.70.6-0.7-0.7-0.6-0.3-0.4-0.8
Std. dev. time between licks in bursts1.22.33.51.61.5-1.51.5-1.51.51.51.51.81.90.7
Total sessions with >9 infusions1.21.52.81.61.5-1.21.4-1.50.90.90.80.80.61.7
Short access day 1 total inactive lever presses0.81.62.31.51.5-1.31.5-1.51.01.01.11.31.30.8
Short access day 10 total inactive lever presses0.32.02.7-1.5-1.51.3-1.41.4-1.5-1.5-1.3-1.6-1.6-0.4
Short access day 1 total infusions0.51.11.91.41.4-1.01.3-1.30.70.70.70.80.61.2
Short access day 10 total infusions1.01.62.21.51.4-1.41.4-1.51.11.11.11.11.01.2
Short access total infusions1.31.92.71.61.6-1.41.6-1.61.11.11.11.00.81.6
Short access day 1 locomotion0.10.20.80.60.6-0.50.6-0.60.20.20.10.00.00.9
Short access day 10 total locomotion0.10.41.00.80.7-0.80.8-0.80.50.50.40.30.31.0
Short access total locomotion1.52.24.71.71.6-1.61.7-1.71.21.21.20.90.72.2
One hour access (0.3 mA shock)0.30.30.60.60.7-0.60.7-0.70.30.30.40.70.8-0.1
Compulsive drug intake0.10.10.6-0.2-0.30.4-0.20.2-0.4-0.4-0.5-0.10.1-0.8
One hour access (shock baseline)0.40.91.21.01.0-1.11.0-1.00.90.91.00.80.71.0
Social response proportion0.00.10.10.20.2-0.30.2-0.30.30.30.20.20.20.2
Social responses1.72.22.6-1.5-1.41.5-1.61.4-1.6-1.6-1.6-1.3-1.1-1.6
Social time0.10.20.4-0.6-0.60.3-0.50.6-0.2-0.2-0.2-0.3-0.1-0.5
Soleus weight3.29.413.1-3.2-3.13.1-3.23.1-3.1-3.1-3.0-3.5-3.6-1.1
Bone: stiffness1.93.54.0-2.0-2.01.9-2.02.0-1.9-1.9-1.8-1.9-1.9-1.2
Tibialis anterior weight0.20.81.1-1.0-0.90.9-0.90.9-0.9-0.9-0.8-0.8-0.8-0.8
Time to tail flick, vehicle, before self-admin0.00.00.1-0.00.0-0.00.1-0.00.30.30.30.20.10.0
Time to tail flick, vehicle, after self-admin0.20.40.5-0.7-0.70.6-0.60.6-0.6-0.6-0.7-0.6-0.6-0.4
Time to tail flick, test, before self-admin1.01.12.71.11.2-1.21.2-1.10.90.90.90.50.41.6
Time to tail flick, test, after self-admin0.30.30.70.30.2-0.40.4-0.40.50.50.70.80.9-0.3
Delta time to tail flick, vehicle, before/after SA2.22.32.9-1.5-1.51.5-1.61.5-1.7-1.7-1.7-1.4-1.2-1.3
Delta time to tail flick, test, before/after SA0.30.31.4-0.6-0.70.6-0.70.5-0.3-0.3-0.20.10.1-1.2
Tibia length0.20.40.6-0.6-0.60.7-0.60.6-0.8-0.8-0.7-0.7-0.5-0.6
Ambulatory time before self-admin0.41.13.61.31.1-0.90.9-0.81.01.01.00.40.01.9
Ambulatory time after self-admin2.23.55.01.91.9-1.91.9-1.82.02.02.11.51.12.2
Bone: tissue strength0.10.10.30.30.3-0.10.2-0.20.20.20.20.40.5-0.3
Total heroin consumption6.77.810.2-2.9-3.22.7-2.83.0-2.9-2.9-2.9-2.6-2.2-2.5
Bone: trabecular number1.01.82.3-1.3-1.41.5-1.51.4-1.4-1.4-1.4-1.1-1.0-1.5
Bone: trabecular spacing2.63.94.62.12.0-2.12.1-2.01.91.91.92.12.11.0
Bone: trabecular thickness9.513.215.5-3.9-3.73.8-3.83.7-3.7-3.7-3.6-3.5-3.3-3.0
Bone: trabecular tissue density2.54.35.12.02.1-2.12.1-2.12.32.32.22.01.91.7
Water consumed over 24 hours0.61.12.0-0.8-0.91.1-1.01.0-1.1-1.1-1.1-1.2-1.4-0.4
Number of responses in last shaping day0.81.01.71.21.3-1.01.1-1.20.90.90.90.70.41.3