Hub : Genes

Ces2c

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 OFC gene expression Ces2c 0.29 0.15 6.8e-07 0.3 0.28 0.28 0.2 5.7e-08 1.8e-07 2.2e-07 1.7e-05
2 pVTA gene expression Ces2c 0.34 0.14 0.0e+00 0.35 0.35 0.34 0.35 2.5e-29 7.2e-29 4.9e-28 6.8e-29
3 Liver mRNA stability Ces2c 0.02 0.01 6.5e-03 0.01 0.01 0.01 0.01 7.1e-03 1.4e-02 7.1e-02 2.9e-02
4 Brain gene expression Ces2c 0.23 0.12 0.0e+00 0.27 0.27 0.27 0.26 2.7e-25 6.1e-25 8.8e-25 1.0e-24
5 PL gene expression Ces2c 0.64 0.02 0.0e+00 0.37 0.36 0.37 0.37 2.0e-42 1.8e-41 1.8e-42 6.6e-43
6 IL gene expression Ces2c 0.38 0.17 1.0e-08 0.3 0.26 0.23 0.27 5.3e-08 6.3e-07 3.6e-06 2.9e-07
7 BLA gene expression Ces2c 0.25 0.13 4.0e-12 0.17 0.16 0.16 0.16 2.6e-09 4.7e-09 7.9e-09 6.7e-09
8 IC gene expression Ces2c 0.26 0.14 6.7e-10 0.22 0.21 0.21 0.21 1.9e-09 4.5e-09 2.4e-09 4.2e-09
9 NAcc gene expression Ces2c 0.15 0.07 0.0e+00 0.17 0.21 0.21 0.21 1.1e-25 2.6e-31 1.0e-31 1.4e-31
10 LHb gene expression Ces2c 0.26 0.15 6.2e-05 0.14 0.18 0.21 0.15 3.8e-04 4.1e-05 1.2e-05 2.3e-04
11 Adipose gene expression Ces2c 0.12 0.08 4.0e-08 0.06 0.07 0.07 0.06 6.7e-07 8.5e-08 4.0e-08 2.2e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density1.42.43.01.51.6-1.71.71.61.61.61.61.31.11.7
Area under the delay curve0.50.60.80.60.7-0.90.90.90.70.70.60.60.80.8
BMI with tail26.792.298.79.99.9-9.99.99.99.99.99.99.69.07.6
BMI without tail19.659.864.08.07.9-8.07.97.98.08.08.07.77.36.0
Body weight22.397.5106.310.310.2-10.210.110.210.210.210.29.68.98.4
Weight adjusted by age4.67.18.52.92.8-2.72.92.92.62.62.62.82.51.7
Bone surface1.42.53.01.61.6-1.71.61.61.71.71.61.41.21.6
Bone volume3.46.16.92.52.5-2.62.52.52.62.62.62.42.22.1
Breakpoint value in progressive ratio session4.65.56.82.22.5-2.42.32.52.62.62.52.11.82.3
Number of licking bursts0.10.21.30.20.3-0.30.30.20.40.40.4-0.1-0.31.2
Context. condit. distance diff. score0.20.20.3-0.5-0.40.5-0.5-0.4-0.5-0.5-0.4-0.5-0.5-0.1
Locomotion velocity, session 11.51.61.8-1.3-1.31.3-1.3-1.3-1.3-1.3-1.3-1.3-1.4-0.7
Locomotion distance, session 12.73.44.0-1.9-1.91.9-1.9-1.9-1.9-1.9-2.0-1.6-1.5-1.9
Locomotion velocity, session 21.21.42.0-1.2-1.31.2-1.2-1.2-1.2-1.2-1.3-0.9-0.7-1.4
Locomotion distance, session 20.10.20.60.20.2-0.20.20.20.30.30.20.60.8-0.6
Locomotion velocity, session 32.93.33.9-1.9-1.91.8-1.8-1.8-2.0-2.0-2.0-1.8-1.6-1.4
Locomotion distance, session 31.51.62.0-1.4-1.31.3-1.3-1.3-1.3-1.3-1.3-1.1-1.0-1.1
Stereotopy head waving bouts, day 30.30.40.9-0.6-0.50.6-0.5-0.5-0.7-0.7-0.6-0.4-0.3-1.0
Stereotopy head waving duration, day 30.10.10.3-0.2-0.20.2-0.2-0.2-0.4-0.4-0.3-0.1-0.1-0.6
Locomotion velocity, session 70.10.10.2-0.3-0.40.4-0.3-0.3-0.4-0.4-0.3-0.4-0.50.0
Locomotion distance, session 70.00.00.10.10.1-0.10.10.10.10.10.10.30.3-0.2
Stereotopy head waving bouts, day 70.20.20.80.40.5-0.40.40.40.50.50.50.0-0.20.9
Stereotopy head waving duration, day 70.20.21.10.00.1-0.10.10.10.10.1-0.0-0.6-0.81.0
Locomotion velocity, session 82.83.44.5-1.8-1.91.8-1.9-1.9-1.9-1.9-2.0-2.1-2.0-0.9
Locomotion distance, session 81.21.72.1-1.4-1.31.4-1.4-1.4-1.3-1.3-1.3-1.3-1.2-1.1
Degree of sensitization distance1.61.62.31.51.4-1.31.41.41.31.31.21.31.20.9
Degree of sensitization stereotypy0.70.82.40.70.9-0.80.80.81.01.00.90.3-0.11.6
Conditioned locomotion0.00.00.1-0.00.1-0.10.00.10.30.30.30.10.00.2
Cocaine response after cond. corrected4.45.311.2-2.3-2.32.3-2.3-2.3-2.4-2.4-2.4-1.5-0.9-3.3
Cocaine response after cond. not corrected5.76.79.9-2.6-2.72.7-2.6-2.6-2.7-2.7-2.7-2.0-1.6-3.2
Cocaine response before conditioning0.20.31.4-0.0-0.20.2-0.2-0.2-0.2-0.2-0.1-0.8-1.21.0
Saline control response0.20.31.3-0.5-0.40.5-0.5-0.4-0.7-0.7-0.6-0.00.2-1.1
Bone: connectivity density0.00.00.1-0.1-0.1-0.10.0-0.00.00.0-0.0-0.2-0.30.3
Bone: cortical apparent density9.613.115.0-3.7-3.73.9-3.8-3.7-3.7-3.7-3.7-3.2-2.9-3.7
Bone: cortical area11.918.220.24.54.5-4.54.54.44.44.44.34.23.93.5
Bone: cortical porosity0.30.40.70.70.6-0.70.70.60.60.60.50.40.30.8
Bone: cortical porosity1.81.92.81.51.5-1.51.61.41.41.41.31.10.91.7
Bone: cortical thickness6.711.112.83.63.5-3.43.53.43.33.33.23.53.42.2
Bone: cortical thickness7.18.311.43.02.9-2.92.92.82.92.92.93.33.41.2
Bone: cortical tissue density10.714.616.6-4.0-3.94.1-4.0-3.9-3.9-3.9-3.9-3.4-3.1-3.8
Condit. Reinf. active minus inactive responses2.62.93.5-1.7-1.71.7-1.7-1.7-1.8-1.8-1.8-1.9-1.9-0.9
Condit. Reinf. active-inactive response ratio2.42.63.6-1.5-1.61.6-1.6-1.6-1.7-1.7-1.6-1.8-1.9-0.8
Condit. Reinf. active responses0.20.30.4-0.5-0.50.5-0.5-0.5-0.6-0.6-0.5-0.6-0.6-0.1
Condit. Reinf. inactive responses0.91.11.21.01.1-1.01.11.11.01.01.01.11.01.0
Incentive salience index mean1.82.22.5-1.5-1.51.5-1.5-1.5-1.6-1.6-1.5-1.5-1.5-1.0
Condit. Reinf. lever presses0.91.31.6-1.2-1.31.2-1.3-1.3-1.2-1.2-1.1-1.0-0.9-1.0
Condit. Reinf. active minus inactive responses1.82.44.31.51.6-1.51.61.61.61.61.61.10.72.1
Condit. Reinf. active-inactive response ratio3.13.64.81.91.9-1.91.91.92.12.12.11.61.22.2
Condit. Reinf. active responses1.92.75.21.71.7-1.61.71.71.71.71.71.10.72.3
Condit. Reinf. inactive responses0.50.71.61.00.9-0.91.00.90.70.70.60.40.31.3
Condit. Reinf. lever presses1.41.92.31.51.5-1.41.51.51.31.31.31.31.11.4
Condit. Reinf. lever reinforcers received0.91.33.21.21.2-1.11.21.21.21.21.10.70.31.8
Conditioned reinforcement - actives1.11.82.4-1.5-1.51.5-1.5-1.5-1.2-1.2-1.2-1.2-1.1-1.3
Conditioned reinforcement - inactives0.71.01.4-1.1-1.01.1-1.2-1.2-0.8-0.8-0.9-1.0-1.2-0.5
Conditioned locomotion2.63.44.2-2.0-1.92.0-2.0-2.0-1.8-1.8-1.6-1.5-1.5-1.8
Patch foraging indifference point 0 sec4.38.09.22.93.0-3.03.03.02.82.82.72.92.91.9
Patch foraging indifference point AUC0.10.10.20.30.4-0.30.20.30.40.40.30.50.40.1
Delay disc. indifference point, 0s delay0.50.50.90.91.0-0.80.90.90.50.50.20.71.00.2
Delay disc. indifference point, 16s delay0.40.41.20.50.6-0.70.70.70.60.60.60.20.31.1
Delay disc. indifference point, 2s delay0.00.00.3-0.1-0.1-0.20.10.10.00.0-0.10.20.5-0.4
Delay disc. indifference point, 24s delay0.60.71.00.80.9-1.01.01.00.80.80.70.70.90.8
Delay disc. indifference point, 4s delay0.30.30.50.50.6-0.70.60.60.50.50.30.40.70.7
Delay disc. indifference point, 8s delay0.00.00.10.10.2-0.30.30.30.10.10.10.20.30.1
Indifference point function ln k0.10.10.30.50.4-0.30.40.40.20.20.20.40.6-0.1
Indifference point function log k0.10.10.30.50.4-0.30.40.40.20.20.20.40.6-0.1
Patch foraging total patch changes 0 sec5.510.311.73.33.4-3.43.43.43.23.23.13.33.32.2
Patch foraging total patch changes 12 sec3.64.75.42.12.3-2.22.32.32.22.22.12.32.21.5
Patch foraging total patch changes 18 sec1.82.83.31.71.8-1.71.71.71.71.71.71.81.71.2
Patch foraging total patch changes 24 sec0.30.50.80.60.9-0.80.80.90.70.70.60.80.80.4
Patch foraging total patch changes 6 sec4.26.37.22.62.7-2.72.62.62.52.52.42.62.61.6
Patch foraging time to switch 0 sec0.91.82.6-1.6-1.51.3-1.3-1.4-1.3-1.3-1.2-1.5-1.4-0.8
Patch foraging water rate 0 sec2.14.45.22.22.2-2.12.22.22.12.12.02.32.31.3
Patch foraging water rate 12 sec2.55.36.02.32.5-2.32.42.42.42.42.32.22.12.0
Patch foraging water rate 18 sec1.01.63.21.41.4-1.11.21.21.11.11.01.61.80.0
Patch foraging water rate 24 sec3.34.78.92.32.3-2.22.12.21.91.91.92.73.00.4
Patch foraging water rate 6 sec1.92.84.81.91.8-1.71.81.71.51.51.42.02.20.5
Seeking ratio, delayed vs. immediate footshock9.411.515.1-3.9-3.83.3-3.5-3.6-3.4-3.4-3.4-3.3-2.9-2.5
Distance traveled before self-admin1.31.74.8-1.5-1.31.2-1.2-1.2-1.4-1.4-1.4-0.7-0.3-2.2
Distance traveled after self-admin2.73.35.0-1.8-1.81.8-1.8-1.7-2.0-2.0-2.1-1.5-1.0-2.2
Extensor digitorum longus weight1.97.68.42.82.8-2.92.82.82.82.82.82.82.72.1
Bone: elastic displacement0.30.30.90.60.5-0.60.60.50.50.50.50.80.9-0.0
Bone: elastic work2.63.46.41.81.7-1.91.91.71.71.71.72.32.50.3
Bone: endosteal estimation1.84.05.01.92.0-2.12.02.02.22.22.21.91.61.9
Bone: endosteal perimeter3.88.19.12.92.9-3.02.92.93.03.03.02.72.42.6
Epididymis fat weight25.888.496.19.89.8-9.79.79.79.79.79.78.77.98.9
Delta time in closed arm before/after self-admin0.20.10.9-0.4-0.40.4-0.3-0.3-0.2-0.20.00.20.2-0.9
Delta time in open arm before/after self-admin1.51.56.01.31.3-1.21.21.21.01.00.70.2-0.02.4
Diff in mean of infusions in LGA sessions1.31.62.31.31.4-1.21.31.41.31.31.51.20.71.2
Delay discount exponential model param0.50.60.9-0.6-0.70.9-0.9-0.9-0.8-0.8-0.7-0.6-0.9-0.7
Extinction: sum of active levers before priming0.60.61.20.80.8-0.70.70.80.90.90.80.60.31.1
Active lever presses in extinction session 64.04.05.02.12.2-1.92.02.12.12.12.12.21.81.2
Bone: final force8.012.714.43.73.7-3.83.83.73.53.53.53.63.62.3
Bone: final moment8.313.315.03.83.8-3.93.93.83.63.63.63.73.62.5
Food consumed during 24 hour testing period0.30.40.60.60.6-0.60.60.60.70.70.70.80.70.4
Glucose9.314.716.93.94.1-4.04.14.13.93.93.83.32.94.0
Heart weight15.123.326.34.94.8-5.15.15.05.15.15.04.44.14.3
Delay discount hyperbolic model param0.60.60.9-0.6-0.70.9-0.9-0.9-0.8-0.8-0.7-0.7-0.9-0.7
Intermittent access intake day 1-15 change0.00.10.4-0.2-0.10.3-0.2-0.2-0.3-0.3-0.4-0.10.0-0.7
Intermittent access intake escalation0.00.00.1-0.10.10.1-0.1-0.1-0.1-0.1-0.20.0-0.0-0.3
Intermittent access intake escalation 20.20.20.40.50.6-0.30.60.60.40.40.20.50.40.1
Intermitt. access day 1 inactive lever presses0.31.22.11.21.2-1.11.11.11.21.21.00.80.51.4
Intermitt. access day 15 inactive lever presses0.91.92.51.51.5-1.31.31.41.61.61.31.51.30.9
Intermitt. access escalation Index0.30.50.9-0.6-0.50.7-0.6-0.6-0.8-0.8-0.9-0.8-0.8-0.3
Intermittent access day 1 total infusions0.20.30.5-0.7-0.60.6-0.7-0.7-0.4-0.4-0.4-0.4-0.3-0.6
Intermittent access day 15 total infusions0.10.20.5-0.4-0.40.5-0.5-0.5-0.3-0.3-0.4-0.2-0.2-0.7
Intermittent access terminal intake (last 3 days)0.00.00.2-0.2-0.20.2-0.1-0.20.10.1-0.00.00.1-0.4
Intermittent access total infusions0.40.50.8-0.8-0.80.8-0.9-0.9-0.4-0.4-0.5-0.5-0.5-0.8
Intermittent access day 1 locomotion1.11.42.5-1.2-1.31.4-1.4-1.3-1.1-1.1-1.0-0.8-0.7-1.6
Intermittent access day 15 total locomotion0.00.00.1-0.1-0.20.3-0.3-0.3-0.1-0.1-0.0-0.1-0.2-0.1
Intermittent access total locomotion1.11.32.4-1.2-1.21.3-1.2-1.3-1.0-1.0-1.0-0.7-0.7-1.6
Intermittent access standard deviation0.30.50.70.60.8-0.80.70.70.80.80.70.70.80.5
Left kidney weight9.544.450.66.66.7-6.86.76.87.07.06.97.16.94.4
Right kidney weight11.150.661.27.07.1-7.37.27.27.37.37.37.77.84.1
Cocaine induced anxiety1.62.33.6-1.8-1.61.6-1.6-1.6-1.4-1.4-1.4-1.1-1.0-1.9
Post-drug Anxiety0.00.00.1-0.10.00.1-0.1-0.1-0.0-0.0-0.0-0.2-0.30.3
Baseline Anxiety2.02.36.21.91.6-1.51.51.51.31.31.40.80.42.5
Tail length0.31.42.21.31.1-1.11.11.11.31.31.20.90.71.5
Length with tail2.08.59.93.23.0-3.02.93.03.03.02.92.62.33.1
Length without tail4.012.915.93.83.8-3.73.73.73.73.73.63.02.64.0
Times rat made contact with spout1.51.71.91.21.4-1.31.41.41.31.31.31.31.11.1
Lifetime Intake0.50.61.0-1.0-1.00.9-1.0-1.0-0.5-0.5-0.5-0.5-0.4-0.9
Liver weight, left10.918.019.94.44.5-4.44.44.44.34.34.34.24.03.4
Liver weight, right3.05.36.22.52.5-2.52.32.42.22.22.12.42.41.6
Locomotor activity0.20.30.6-0.2-0.20.5-0.2-0.2-0.8-0.8-0.8-0.6-0.6-0.3
Locomotor testing distance0.71.32.4-1.0-1.01.1-0.9-0.9-1.5-1.5-1.5-1.0-0.7-1.4
Locomotor testing rearing0.10.20.50.30.5-0.40.50.5-0.1-0.1-0.20.40.7-0.4
Locomotion in novel chamber0.30.41.30.20.3-0.40.20.30.60.60.40.91.1-0.9
Locomotion in novel chamber post-restriction0.10.21.70.0-0.00.10.00.0-0.0-0.00.00.60.8-1.3
Fecal boli incidents, locomotor time 10.50.71.80.60.8-0.70.70.80.90.91.10.50.31.3
Change in fecal boli incidents, locomotor task0.20.20.30.50.5-0.30.30.40.40.40.30.60.5-0.1
Time >=10cm from walls, locomotor time 10.10.10.3-0.3-0.20.3-0.4-0.3-0.5-0.5-0.4-0.5-0.40.0
Bouts of movement, locomotor time 10.30.30.60.60.6-0.60.70.60.40.40.40.20.30.8
Total resting periods, locomotor time 10.30.30.50.60.6-0.70.70.60.40.40.40.40.50.5
Rest time, locomotor task time 10.81.02.40.90.8-1.00.90.81.01.01.01.31.5-0.3
Distance moved, locomotor task time 10.20.20.4-0.3-0.30.5-0.4-0.3-0.6-0.6-0.7-0.6-0.6-0.1
Vertical activity count, locomotor time 10.40.91.2-0.8-0.90.9-0.9-0.8-1.1-1.1-1.0-0.9-0.9-0.7
Time >=10cm from walls, locomotor time 20.10.10.30.20.4-0.30.30.30.10.10.10.30.5-0.2
Bouts of movement, locomotor time 20.00.00.1-0.2-0.10.0-0.0-0.10.00.0-0.1-0.00.1-0.2
Total resting periods, locomotor time 20.00.00.1-0.3-0.10.1-0.1-0.1-0.1-0.1-0.2-0.1-0.0-0.3
Rest time, locomotor task time 20.10.10.4-0.1-0.20.1-0.1-0.2-0.4-0.4-0.6-0.3-0.1-0.4
Distance moved, locomotor task time 20.00.00.2-0.2-0.30.2-0.1-0.1-0.1-0.1-0.10.00.0-0.5
Vertical activity count, locomotor time 20.20.20.3-0.5-0.50.5-0.5-0.5-0.5-0.5-0.3-0.4-0.4-0.6
Light reinforcement 10.20.51.9-0.6-0.70.6-0.5-0.6-0.5-0.5-0.7-0.00.3-1.4
Light reinforcement 20.20.30.5-0.7-0.70.5-0.6-0.7-0.3-0.3-0.4-0.6-0.6-0.2
Bone: marrow area2.14.55.52.12.1-2.22.22.12.32.32.32.01.71.9
Bone: maximum diameter6.311.813.13.63.5-3.63.53.53.63.63.63.02.63.6
Bone: maximum force5.39.510.83.23.2-3.33.33.23.13.13.13.13.12.1
Bone: maximum moment5.59.711.13.23.2-3.33.33.33.13.13.13.13.02.2
Mean time between licks in bursts0.30.72.1-0.7-0.70.7-0.6-0.7-0.6-0.6-0.6-1.2-1.40.3
Mean num. licks in bursts0.20.41.20.40.5-0.40.50.50.40.40.40.91.1-0.7
Cd content in liver0.20.21.3-0.1-0.0-0.0-0.0-0.0-0.0-0.0-0.20.60.9-1.2
Co content in liver0.30.31.40.30.3-0.30.30.30.30.30.20.81.2-0.9
Cu content in liver0.20.20.40.30.4-0.50.30.30.60.60.60.60.60.1
Fe content in liver0.30.41.80.60.5-0.50.40.40.70.70.70.1-0.31.4
K content in liver0.30.20.40.40.4-0.50.40.40.60.60.60.50.60.3
Mg content in liver0.90.92.10.80.9-1.00.90.91.01.00.91.31.5-0.0
Mn content in liver0.80.91.80.90.9-1.01.00.90.90.90.81.11.30.1
Na content in liver2.83.03.71.71.7-1.91.71.71.81.81.91.71.71.4
Rb content in liver0.20.20.30.40.5-0.50.50.50.40.40.40.40.40.5
Se content in liver0.00.00.1-0.2-0.30.2-0.3-0.3-0.1-0.1-0.0-0.2-0.2-0.2
Sr content in liver2.52.26.2-1.5-1.51.5-1.2-1.2-1.5-1.5-1.6-1.0-0.6-2.5
Zn content in liver0.20.31.6-0.4-0.30.2-0.4-0.4-0.2-0.2-0.30.30.6-1.3
Bone: minimum diameter6.812.413.93.63.7-3.73.73.63.63.63.63.22.83.4
Time in familiar zone, hab. session 12.72.73.11.81.7-1.71.71.71.71.71.61.51.41.4
Time in novel zone, hab. session 14.74.76.5-2.2-2.22.3-2.2-2.2-2.2-2.2-2.2-2.4-2.6-1.0
Total zone transitions, hab. session 10.00.10.30.0-0.10.1-0.1-0.1-0.1-0.1-0.10.30.4-0.6
Total locomotion distance, hab. session 10.20.20.6-0.4-0.40.5-0.4-0.4-0.5-0.5-0.5-0.6-0.70.0
Locomotion velocity, hab. session 10.10.10.2-0.2-0.30.3-0.3-0.3-0.4-0.4-0.3-0.4-0.5-0.0
Time in familiar zone, hab. session 20.70.72.5-0.5-0.50.6-0.5-0.5-0.7-0.7-0.7-1.4-1.60.8
Time in novel zone, hab. session 20.40.41.10.50.4-0.50.50.50.70.70.71.01.0-0.3
Total zone transitions, hab. session 20.10.10.30.30.2-0.20.30.30.20.20.20.50.5-0.3
Total locomotion distance, hab. session 20.40.50.60.70.7-0.70.80.70.80.80.70.60.50.6
Locomotion velocity, hab. session 20.60.80.90.90.9-0.91.00.90.90.90.90.90.80.6
Novel to familiar place preference ratio0.20.30.9-0.3-0.40.4-0.4-0.3-0.4-0.4-0.4-0.9-1.00.4
Novelty place preference0.30.31.0-0.3-0.40.4-0.4-0.4-0.4-0.4-0.4-0.9-1.00.3
Time in novel zone, NPP test0.30.41.5-0.2-0.30.2-0.2-0.2-0.3-0.3-0.3-1.0-1.20.9
Total zone transitions, NPP test0.20.20.70.30.3-0.30.30.30.40.40.30.80.8-0.4
Total locomotion distance, NPP test0.00.00.10.00.1-0.00.10.10.10.10.10.30.3-0.3
Locomotion velocity, NPP test0.10.21.3-0.2-0.10.2-0.1-0.1-0.0-0.0-0.10.50.7-1.1
Intraocular pressure0.10.20.9-0.1-0.00.0-0.1-0.1-0.0-0.0-0.1-0.6-0.70.9
Delta distance traveled before/after self-admin0.40.50.7-0.4-0.60.8-0.7-0.7-0.7-0.7-0.8-0.7-0.6-0.5
Delta ambulatory time before/after self-admin0.30.40.6-0.4-0.60.7-0.7-0.6-0.7-0.7-0.8-0.6-0.6-0.4
Parametrial fat weight30.371.377.98.88.7-8.88.88.78.68.68.68.17.67.2
Pavlov. Cond. lever latency0.30.30.5-0.6-0.60.5-0.5-0.5-0.5-0.5-0.7-0.7-0.6-0.3
Pavlov. Cond. magazine entry latency0.30.40.70.60.7-0.60.60.60.60.60.70.50.40.8
Pavlov. Cond. change in total contacts1.92.03.61.41.6-1.51.51.51.41.41.51.00.71.9
Pavlov. Cond. index score0.81.01.30.91.0-1.01.01.01.01.01.10.90.81.1
Pavlov. Cond. latency score0.60.81.00.80.9-0.90.80.80.90.91.00.80.70.9
Pavlov. Cond. lever contacts0.91.11.51.01.1-1.11.01.01.11.11.21.00.91.0
Pavlov. Cond. magazine entry number0.70.81.1-0.8-1.00.9-0.9-0.9-0.9-0.9-1.0-0.8-0.7-1.0
Pavlov. Cond. intertrial magazine entries1.01.21.71.11.1-1.11.11.11.11.11.01.21.30.4
Pavlov. Cond. lever-magazine prob. diff.0.81.01.50.91.1-1.01.01.01.01.01.10.90.81.2
Pavlov. Cond. response bias0.40.50.60.70.8-0.70.70.70.70.70.80.70.60.7
Pavlov. Cond. lever latency0.50.71.9-0.9-0.90.8-0.8-0.8-0.9-0.9-0.8-0.5-0.3-1.4
Pavlov. Cond. magazine entry latency0.30.41.4-0.2-0.40.5-0.4-0.4-0.4-0.4-0.5-1.0-1.20.6
Pavlov. Cond. change in total contacts0.20.31.00.50.6-0.50.50.50.70.70.60.20.01.0
Pavlov. Cond. index score0.10.10.80.30.3-0.20.20.20.20.20.1-0.2-0.40.9
Pavlov. Cond. latency score0.10.10.60.30.3-0.20.20.20.20.20.2-0.1-0.20.8
Pavlov. Cond. lever contacts0.40.51.20.80.8-0.70.70.70.70.70.70.50.41.1
Pavlov. Cond. magazine entry number0.10.10.60.10.2-0.30.20.30.30.30.30.60.7-0.4
Pavlov. Cond. intertrial magazine entries2.84.27.02.02.1-2.12.12.12.02.01.92.52.60.6
Pavlov. Cond. lever-magazine prob. diff.0.10.10.50.20.1-0.00.10.00.10.1-0.0-0.3-0.50.7
Pavlov. Cond. response bias0.20.31.90.50.4-0.40.40.40.50.50.4-0.1-0.41.4
Time in closed arm before self-admin0.10.10.2-0.2-0.30.3-0.4-0.3-0.4-0.4-0.5-0.3-0.3-0.1
Time in closed arm after self-admin0.40.51.7-0.9-0.80.8-0.7-0.6-0.5-0.5-0.3-0.0-0.1-1.3
Time in open arm before self-admin0.91.01.5-1.2-1.21.0-1.0-1.2-0.9-0.9-0.8-1.0-0.8-0.8
Time in open arm after self-admin0.50.53.50.60.6-0.60.50.50.50.50.3-0.4-0.51.9
Bone: periosteal estimation7.515.917.44.14.1-4.24.14.14.14.14.23.93.63.3
Bone: periosteal perimeter12.221.023.14.74.7-4.84.74.74.84.84.84.44.04.0
Bone: post-yield work0.20.40.80.50.6-0.60.60.60.70.70.60.30.20.9
Progressive ratio test 1 active lever presses0.70.91.3-1.1-1.11.0-1.1-1.1-0.8-0.8-0.8-0.7-0.5-1.1
Progressive ratio test 1 breakpoint0.50.61.0-0.9-0.90.8-0.9-0.9-0.6-0.6-0.6-0.5-0.4-1.0
Progressive ratio test 1 inactive lever presses0.10.20.4-0.6-0.50.4-0.6-0.6-0.2-0.2-0.4-0.5-0.4-0.3
Progressive ratio test 2 active lever presses0.00.00.3-0.0-0.20.1-0.1-0.10.10.10.00.20.3-0.5
Progressive ratio test 2 breakpoint0.00.00.2-0.1-0.20.1-0.1-0.10.20.20.00.20.3-0.5
Progressive ratio test 2 inactive lever presses0.10.10.2-0.4-0.30.4-0.4-0.4-0.2-0.2-0.4-0.3-0.3-0.5
Incentive Sensitization - Responses0.40.50.70.80.7-0.70.70.70.80.80.70.70.70.4
Incentive Sensitization - Breakpoint0.20.30.50.60.5-0.50.60.60.70.70.50.60.50.3
Sum of active levers in priming session hrs 5-60.30.30.50.70.7-0.50.50.60.60.60.50.60.40.4
Progressive ratio1.52.43.3-1.7-1.71.3-1.6-1.6-1.6-1.6-1.8-1.4-1.0-1.6
Food seeking constrained by brief footshock4.85.97.3-2.3-2.42.4-2.6-2.6-2.5-2.5-2.7-2.5-2.4-1.6
Seeking ratio, punishment vs. effort0.10.20.3-0.2-0.30.5-0.5-0.5-0.4-0.4-0.3-0.4-0.6-0.1
Retroperitoneal fat weight28.4121.0135.611.611.4-11.311.311.311.311.311.310.59.69.8
Reaction time number correct0.30.61.20.90.6-0.90.90.80.90.90.70.50.51.1
Reaction time mean minus median0.00.00.1-0.00.1-0.10.10.1-0.0-0.00.10.20.4-0.3
Reaction time mean minus median AUC0.10.41.30.20.4-0.60.60.50.50.50.50.81.1-0.3
Reaction time num false alarms0.00.10.30.1-0.10.2-0.1-0.2-0.3-0.3-0.4-0.00.1-0.5
Reaction time num false alarms AUC0.10.10.30.50.3-0.30.40.30.10.10.10.40.5-0.1
Reaction time trials correct on left0.30.61.20.90.6-0.90.90.80.90.90.70.50.51.1
Reaction time trials on left0.30.61.20.90.6-0.90.80.80.80.80.70.50.51.1
Reaction time mean1.11.72.3-1.5-1.41.4-1.2-1.3-1.4-1.4-1.2-1.2-1.1-1.2
Reaction time mean AUC1.01.72.4-1.5-1.41.3-1.2-1.3-1.3-1.3-1.2-1.1-0.9-1.4
Median of all reaction times1.82.63.2-1.8-1.71.7-1.5-1.7-1.6-1.6-1.5-1.5-1.4-1.4
Reaction time omissions0.20.30.8-0.4-0.50.5-0.4-0.5-0.6-0.6-0.5-0.8-0.90.2
Reaction time false alarm rate0.00.10.30.0-0.10.2-0.1-0.2-0.3-0.3-0.30.00.1-0.5
Reaction time premature initiation rate0.20.30.7-0.5-0.30.6-0.5-0.3-0.6-0.6-0.6-0.2-0.3-0.9
Reaction time premature initiations0.00.10.20.30.3-0.10.20.40.10.10.00.30.3-0.1
Std. dev. reaction times0.00.00.0-0.1-0.0-0.00.10.0-0.0-0.00.10.10.1-0.1
Reaction time trials completed0.30.61.20.90.6-0.90.80.80.80.80.70.50.51.1
Reaction time trials AUC0.61.11.61.10.9-1.11.11.01.11.11.00.70.71.3
Run reversals in cocaine runway, females0.20.20.3-0.4-0.40.4-0.3-0.3-0.5-0.5-0.5-0.6-0.5-0.0
Run reversals in cocaine runway, males0.40.42.7-0.6-0.60.6-0.5-0.5-0.5-0.5-0.30.00.2-1.6
Latency to leave start box in cocaine runway0.20.21.40.30.3-0.40.40.40.30.30.3-0.2-0.31.2
Latency to leave start box in cocaine runway, F0.20.21.10.60.5-0.40.50.50.30.30.2-0.0-0.21.0
Latency to leave start box in cocaine runway, M0.40.30.60.30.4-0.70.70.60.70.70.60.30.40.8
Std. dev. time between licks in bursts1.72.33.5-1.6-1.51.5-1.5-1.5-1.5-1.5-1.5-1.8-1.9-0.7
Total sessions with >9 infusions1.21.52.8-1.6-1.51.2-1.4-1.5-0.9-0.9-0.8-0.8-0.6-1.7
Short access day 1 total inactive lever presses1.21.62.3-1.5-1.51.3-1.5-1.5-1.0-1.0-1.1-1.3-1.3-0.8
Short access day 10 total inactive lever presses0.82.02.71.51.5-1.31.41.41.51.51.31.61.60.4
Short access day 1 total infusions0.81.11.9-1.4-1.41.0-1.3-1.3-0.7-0.7-0.7-0.8-0.6-1.2
Short access day 10 total infusions1.21.62.2-1.5-1.41.4-1.4-1.5-1.1-1.1-1.1-1.1-1.0-1.2
Short access total infusions1.51.92.7-1.6-1.61.4-1.6-1.6-1.1-1.1-1.1-1.0-0.8-1.6
Short access day 1 locomotion0.20.20.8-0.6-0.60.5-0.6-0.6-0.2-0.2-0.1-0.0-0.0-0.9
Short access day 10 total locomotion0.20.41.0-0.8-0.70.8-0.8-0.8-0.5-0.5-0.4-0.3-0.3-1.0
Short access total locomotion1.82.24.7-1.7-1.61.6-1.7-1.7-1.2-1.2-1.2-0.8-0.7-2.2
One hour access (0.3 mA shock)0.30.30.6-0.6-0.70.6-0.7-0.7-0.3-0.3-0.4-0.7-0.80.1
Compulsive drug intake0.10.10.60.20.3-0.40.20.20.40.40.50.1-0.10.8
One hour access (shock baseline)0.60.91.2-1.0-1.01.1-1.0-1.0-0.9-0.9-1.0-0.8-0.7-1.0
Social response proportion0.00.10.1-0.2-0.20.3-0.2-0.3-0.3-0.3-0.2-0.2-0.2-0.2
Social responses1.72.22.61.51.4-1.51.61.41.61.61.61.31.11.6
Social time0.10.20.40.60.6-0.30.50.60.20.20.20.30.10.5
Soleus weight3.29.413.13.23.1-3.13.23.13.13.13.03.53.61.1
Bone: stiffness2.23.54.02.02.0-1.92.02.01.91.91.81.91.91.2
Tibialis anterior weight0.20.81.11.00.9-0.90.90.90.90.90.80.80.80.8
Time to tail flick, vehicle, before self-admin0.00.00.10.0-0.00.0-0.1-0.0-0.3-0.3-0.3-0.2-0.1-0.0
Time to tail flick, vehicle, after self-admin0.30.40.50.70.7-0.60.60.60.60.60.70.60.60.4
Time to tail flick, test, before self-admin1.11.12.7-1.1-1.21.2-1.2-1.1-0.9-0.9-0.9-0.5-0.4-1.6
Time to tail flick, test, after self-admin0.30.30.7-0.3-0.20.4-0.4-0.4-0.5-0.5-0.7-0.8-0.90.3
Delta time to tail flick, vehicle, before/after SA2.52.32.91.51.5-1.51.61.51.71.71.71.41.21.3
Delta time to tail flick, test, before/after SA0.30.31.40.60.7-0.60.70.50.30.30.2-0.1-0.11.2
Tibia length0.20.40.60.60.6-0.70.60.60.80.80.70.70.50.6
Ambulatory time before self-admin0.71.13.6-1.3-1.10.9-0.9-0.8-1.0-1.0-1.0-0.4-0.0-1.9
Ambulatory time after self-admin3.03.55.0-1.9-1.91.9-1.9-1.8-2.0-2.0-2.1-1.5-1.1-2.2
Bone: tissue strength0.10.10.3-0.3-0.30.1-0.2-0.2-0.2-0.2-0.2-0.4-0.50.3
Total heroin consumption6.77.810.22.93.2-2.72.83.02.92.92.92.62.22.5
Bone: trabecular number1.11.82.31.31.4-1.51.51.41.41.41.41.11.01.5
Bone: trabecular spacing2.93.94.6-2.1-2.02.1-2.1-2.0-1.9-1.9-1.9-2.1-2.1-1.0
Bone: trabecular thickness10.613.215.53.93.7-3.83.83.73.73.73.63.53.33.0
Bone: trabecular tissue density2.94.35.1-2.0-2.12.1-2.1-2.1-2.3-2.3-2.2-2.0-1.9-1.7
Water consumed over 24 hours0.81.12.00.80.9-1.11.01.01.11.11.11.31.40.4
Number of responses in last shaping day1.01.01.7-1.2-1.31.0-1.1-1.2-0.9-0.9-0.9-0.7-0.4-1.3