Hub : Genes

Snx17

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Snx17	0.04	0.04	1.9e-03	0.02	0.02	0.01	0.02	6.7e-03	3.6e-03	1.5e-02	8.9e-03
2	PL	mRNA stability	Snx17	0.04	0.04	4.4e-05	0.04	0.04	0.04	0.04	4.3e-05	3.4e-05	1.8e-05	2.0e-05
3	Adipose	gene expression	Snx17	0.03	0.03	2.8e-03	0.01	0.01	0.01	0.01	1.3e-02	2.7e-02	1.8e-02	2.5e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	4.7	7.9	8.7	3.0	-2.5	-2.9
Area under the delay curve	0.3	0.3	0.8	0.3	0.2	-0.9
BMI with tail	0.4	1.2	1.5	-1.2	1.2	0.9
BMI without tail	0.2	0.4	0.5	-0.7	0.4	0.7
Body weight	1.8	7.4	7.8	-2.8	2.7	2.7
Weight adjusted by age	0.0	0.0	0.0	-0.0	-0.2	-0.1
Bone surface	2.1	3.7	4.4	2.1	-1.6	-2.0
Bone volume	2.2	3.8	4.5	2.1	-1.7	-2.0
Breakpoint value in progressive ratio session	1.5	1.6	1.7	1.2	-1.3	-1.3
Number of licking bursts	0.2	0.2	0.3	0.2	0.5	-0.5
Context. condit. distance diff. score	0.0	0.0	0.0	-0.1	0.1	0.1
Locomotion velocity, session 1	0.1	0.1	0.2	-0.2	0.3	0.4
Locomotion distance, session 1	1.5	1.9	2.3	1.5	-1.0	-1.5
Locomotion velocity, session 2	0.2	0.3	0.5	-0.5	0.7	0.4
Locomotion distance, session 2	0.0	0.0	0.0	-0.0	0.1	0.1
Locomotion velocity, session 3	0.7	0.8	1.3	0.8	-1.1	-0.7
Locomotion distance, session 3	0.8	0.9	1.0	1.0	-0.9	-0.9
Stereotopy head waving bouts, day 3	2.0	2.3	2.8	1.5	-1.7	-1.4
Stereotopy head waving duration, day 3	0.2	0.2	0.4	0.4	-0.6	-0.3
Locomotion velocity, session 7	0.8	0.8	1.0	1.0	-1.0	-0.8
Locomotion distance, session 7	0.0	0.0	0.0	0.1	-0.1	0.0
Stereotopy head waving bouts, day 7	0.0	0.0	0.0	-0.1	0.2	0.0
Stereotopy head waving duration, day 7	0.4	0.4	0.5	0.7	-0.7	-0.6
Locomotion velocity, session 8	0.1	0.1	0.3	0.3	-0.6	-0.0
Locomotion distance, session 8	0.2	0.3	0.3	0.6	-0.4	-0.6
Degree of sensitization distance	0.9	0.9	1.0	-1.0	0.9	1.0
Degree of sensitization stereotypy	0.2	0.2	0.3	-0.4	0.6	0.3
Conditioned locomotion	3.4	4.0	4.3	2.0	-1.9	-2.1
Cocaine response after cond. corrected	0.8	0.9	1.5	1.0	-0.4	-1.2
Cocaine response after cond. not corrected	1.8	2.0	3.0	1.5	-0.9	-1.7
Cocaine response before conditioning	1.3	1.5	2.0	1.2	-1.4	-1.1
Saline control response	0.5	0.7	0.8	0.9	-0.9	-0.7
Bone: connectivity density	4.8	7.5	8.3	2.8	-2.4	-2.9
Bone: cortical apparent density	0.3	0.4	0.5	0.7	-0.5	-0.7
Bone: cortical area	0.2	0.3	0.4	0.6	-0.3	-0.6
Bone: cortical porosity	1.5	1.7	2.4	1.2	-1.6	-1.0
Bone: cortical porosity	1.2	1.3	1.7	1.1	-1.3	-0.9
Bone: cortical thickness	0.1	0.2	0.4	-0.3	0.6	0.2
Bone: cortical thickness	1.4	1.6	1.9	1.3	-1.1	-1.4
Bone: cortical tissue density	0.2	0.3	0.4	0.6	-0.4	-0.6
Condit. Reinf. active minus inactive responses	0.5	0.6	0.9	-0.8	1.0	0.6
Condit. Reinf. active-inactive response ratio	0.5	0.5	0.6	-0.8	0.7	0.6
Condit. Reinf. active responses	0.2	0.3	0.6	0.5	-0.0	-0.8
Condit. Reinf. inactive responses	1.5	1.8	2.4	1.4	-0.9	-1.6
Incentive salience index mean	0.1	0.1	0.2	0.2	0.1	-0.4
Condit. Reinf. lever presses	0.6	0.8	1.4	0.9	-0.4	-1.2
Condit. Reinf. active minus inactive responses	4.4	5.4	5.9	2.3	-2.4	-2.2
Condit. Reinf. active-inactive response ratio	1.1	1.1	1.1	1.1	-1.1	-1.0
Condit. Reinf. active responses	3.6	5.0	5.6	2.2	-2.4	-2.2
Condit. Reinf. inactive responses	2.0	2.5	2.5	1.5	-1.6	-1.6
Condit. Reinf. lever presses	2.1	2.9	3.4	1.7	-1.5	-1.8
Condit. Reinf. lever reinforcers received	3.2	4.5	5.2	2.1	-2.3	-2.0
Conditioned reinforcement - actives	1.0	1.0	2.2	0.9	-1.5	-0.3
Conditioned reinforcement - inactives	2.5	2.8	3.8	1.7	-2.0	-1.3
Conditioned locomotion	0.6	0.7	1.5	0.2	-1.2	0.7
Patch foraging indifference point 0 sec	0.3	0.5	0.6	-0.7	0.6	0.8
Patch foraging indifference point AUC	1.9	2.2	2.4	1.6	-1.4	-1.4
Delay disc. indifference point, 0s delay	3.0	3.3	5.5	-1.7	2.4	1.2
Delay disc. indifference point, 16s delay	0.6	0.6	1.3	0.7	-0.2	-1.2
Delay disc. indifference point, 2s delay	0.3	0.3	0.6	-0.5	0.8	0.4
Delay disc. indifference point, 24s delay	2.8	2.7	5.4	1.5	-0.7	-2.3
Delay disc. indifference point, 4s delay	0.0	0.0	0.1	0.0	0.3	-0.1
Delay disc. indifference point, 8s delay	0.4	0.4	0.9	0.4	0.1	-1.0
Indifference point function ln k	0.0	0.0	0.1	-0.2	0.1	0.3
Indifference point function log k	0.0	0.0	0.1	-0.2	0.1	0.3
Patch foraging total patch changes 0 sec	0.2	0.4	0.4	-0.6	0.6	0.6
Patch foraging total patch changes 12 sec	0.8	1.0	1.1	-1.0	1.1	1.0
Patch foraging total patch changes 18 sec	0.0	0.0	0.0	-0.2	0.1	0.2
Patch foraging total patch changes 24 sec	1.0	1.2	1.5	-1.1	1.0	1.2
Patch foraging total patch changes 6 sec	0.0	0.0	0.0	-0.2	0.1	0.1
Patch foraging time to switch 0 sec	0.0	0.0	0.1	0.1	-0.1	-0.3
Patch foraging water rate 0 sec	0.0	0.0	0.1	-0.1	-0.1	0.3
Patch foraging water rate 12 sec	1.5	2.2	2.5	-1.6	1.3	1.6
Patch foraging water rate 18 sec	0.6	0.8	1.0	-0.9	0.8	1.0
Patch foraging water rate 24 sec	1.7	2.4	2.6	-1.6	1.4	1.6
Patch foraging water rate 6 sec	1.4	2.0	2.1	-1.4	1.4	1.5
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.5	-0.3	-0.3	0.7
Distance traveled before self-admin	0.0	0.0	0.1	0.1	0.1	-0.3
Distance traveled after self-admin	0.9	1.0	1.8	-0.9	1.3	0.6
Extensor digitorum longus weight	4.5	17.7	18.5	4.3	-4.0	-4.3
Bone: elastic displacement	1.0	1.1	1.2	1.0	-1.1	-1.1
Bone: elastic work	1.2	1.5	1.8	1.2	-1.1	-1.3
Bone: endosteal estimation	0.3	0.7	0.8	0.9	-0.9	-0.8
Bone: endosteal perimeter	0.1	0.2	0.3	0.5	-0.4	-0.5
Epididymis fat weight	14.0	32.6	34.9	-5.9	5.3	5.9
Delta time in closed arm before/after self-admin	0.0	0.0	0.1	-0.2	0.3	0.1
Delta time in open arm before/after self-admin	0.4	0.4	0.6	0.6	-0.8	-0.5
Diff in mean of infusions in LGA sessions	0.2	0.2	0.3	0.5	-0.6	-0.3
Delay discount exponential model param	0.6	0.6	1.4	-0.6	0.1	1.2
Extinction: sum of active levers before priming	0.6	0.6	0.8	0.7	-0.6	-0.9
Active lever presses in extinction session 6	0.6	0.6	1.4	0.6	-1.2	-0.2
Bone: final force	0.0	0.1	0.1	0.3	-0.1	-0.2
Bone: final moment	0.1	0.1	0.2	0.4	-0.2	-0.3
Food consumed during 24 hour testing period	0.1	0.1	0.3	0.4	0.0	-0.5
Glucose	0.2	0.3	0.5	-0.6	0.4	0.7
Heart weight	10.6	15.0	16.6	-3.8	3.7	4.1
Delay discount hyperbolic model param	0.5	0.5	1.1	-0.6	0.1	1.0
Intermittent access intake day 1-15 change	0.0	0.0	0.0	0.2	-0.2	0.1
Intermittent access intake escalation	0.0	0.0	0.1	-0.0	0.0	0.4
Intermittent access intake escalation 2	0.5	0.5	0.8	-0.6	0.6	0.9
Intermitt. access day 1 inactive lever presses	0.1	0.1	0.3	0.2	-0.5	-0.0
Intermitt. access day 15 inactive lever presses	6.7	7.3	9.5	2.8	-3.1	-2.2
Intermitt. access escalation Index	0.3	0.3	0.4	-0.5	0.5	0.6
Intermittent access day 1 total infusions	5.0	5.8	6.8	2.4	-2.6	-2.2
Intermittent access day 15 total infusions	1.9	2.1	2.8	1.5	-1.7	-1.1
Intermittent access terminal intake (last 3 days)	1.6	1.8	2.5	1.4	-1.6	-1.0
Intermittent access total infusions	2.0	2.2	3.2	1.5	-1.8	-1.2
Intermittent access day 1 locomotion	2.2	2.3	2.5	1.5	-1.6	-1.4
Intermittent access day 15 total locomotion	0.6	0.6	1.0	0.8	-1.0	-0.5
Intermittent access total locomotion	0.3	0.4	0.8	0.5	-0.9	-0.2
Intermittent access standard deviation	0.2	0.2	0.4	0.3	-0.6	0.0
Left kidney weight	0.0	0.0	0.1	-0.1	0.3	0.0
Right kidney weight	1.1	3.1	4.3	-1.7	2.1	1.5
Cocaine induced anxiety	0.2	0.3	0.5	0.5	-0.7	-0.2
Post-drug Anxiety	0.9	1.1	1.6	-0.9	1.3	0.9
Baseline Anxiety	1.4	1.5	2.4	-1.1	1.6	0.8
Tail length	0.1	0.3	0.4	-0.5	0.3	0.7
Length with tail	1.4	5.2	5.4	-2.3	2.2	2.3
Length without tail	0.7	1.6	2.0	-1.2	1.4	1.2
Times rat made contact with spout	1.9	2.2	3.1	1.6	-1.1	-1.8
Lifetime Intake	2.9	3.3	4.7	1.8	-2.2	-1.4
Liver weight, left	1.5	2.3	2.9	-1.5	1.7	1.4
Liver weight, right	9.3	15.4	16.1	-3.9	4.0	3.8
Locomotor activity	0.2	0.3	0.7	-0.5	0.8	0.1
Locomotor testing distance	0.2	0.3	0.5	0.5	-0.4	-0.7
Locomotor testing rearing	0.9	1.4	2.2	1.1	-1.5	-0.9
Locomotion in novel chamber	0.8	0.9	1.4	-1.0	0.6	1.2
Locomotion in novel chamber post-restriction	1.5	1.8	2.3	-1.5	1.2	1.3
Fecal boli incidents, locomotor time 1	0.3	0.3	0.4	0.6	-0.6	-0.4
Change in fecal boli incidents, locomotor task	4.2	4.0	4.3	-2.0	2.1	1.9
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.1	-0.1	0.3	-0.2
Bouts of movement, locomotor time 1	2.3	2.5	3.0	1.7	-1.3	-1.7
Total resting periods, locomotor time 1	2.5	2.7	3.0	1.7	-1.5	-1.7
Rest time, locomotor task time 1	0.1	0.1	0.2	0.2	-0.4	-0.0
Distance moved, locomotor task time 1	0.9	1.0	1.3	-1.1	1.2	0.8
Vertical activity count, locomotor time 1	0.5	0.5	0.9	-0.7	0.9	0.3
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.2	0.3	-0.4	-0.0
Bouts of movement, locomotor time 2	0.2	0.2	0.4	-0.3	0.7	0.3
Total resting periods, locomotor time 2	0.0	0.0	0.1	-0.1	0.3	0.1
Rest time, locomotor task time 2	1.4	1.7	2.0	1.3	-1.1	-1.4
Distance moved, locomotor task time 2	0.9	1.0	1.1	-1.1	0.9	1.1
Vertical activity count, locomotor time 2	0.5	0.6	0.8	-0.8	0.5	0.9
Light reinforcement 1	3.8	6.9	8.1	2.7	-2.3	-2.8
Light reinforcement 2	3.1	4.1	4.8	2.2	-1.7	-2.2
Bone: marrow area	0.4	0.8	0.9	0.9	-0.9	-0.9
Bone: maximum diameter	0.7	1.3	1.5	1.2	-0.9	-1.2
Bone: maximum force	0.0	0.0	0.0	0.1	0.0	0.1
Bone: maximum moment	0.0	0.0	0.0	0.2	-0.1	-0.1
Mean time between licks in bursts	2.6	3.7	4.2	-1.9	2.0	1.8
Mean num. licks in bursts	0.2	0.2	0.4	0.4	-0.6	-0.3
Cd content in liver	0.0	0.0	0.0	0.0	0.1	-0.0
Co content in liver	5.1	6.0	6.7	2.5	-2.2	-2.6
Cu content in liver	0.0	0.0	0.1	0.2	-0.2	-0.2
Fe content in liver	0.1	0.1	0.1	-0.1	-0.4	0.3
K content in liver	0.2	0.2	0.5	-0.3	0.7	0.2
Mg content in liver	0.3	0.3	0.6	-0.5	0.8	0.4
Mn content in liver	0.6	0.6	0.7	0.8	-0.9	-0.7
Na content in liver	0.3	0.3	0.4	0.6	-0.5	-0.5
Rb content in liver	0.0	0.0	0.0	-0.1	0.1	0.1
Se content in liver	0.4	0.5	0.7	-0.7	0.4	0.9
Sr content in liver	0.2	0.2	0.5	-0.3	0.7	0.1
Zn content in liver	1.5	1.6	1.8	-1.2	1.3	1.2
Bone: minimum diameter	0.1	0.2	0.3	-0.4	0.5	0.5
Time in familiar zone, hab. session 1	0.9	0.8	0.9	-0.9	0.9	1.0
Time in novel zone, hab. session 1	0.4	0.4	0.6	-0.7	0.2	0.8
Total zone transitions, hab. session 1	0.1	0.1	0.2	0.3	-0.1	-0.4
Total locomotion distance, hab. session 1	0.1	0.1	0.2	0.4	-0.3	-0.3
Locomotion velocity, hab. session 1	0.8	1.2	1.4	1.2	-0.8	-1.2
Time in familiar zone, hab. session 2	0.0	0.0	0.0	0.0	0.1	0.1
Time in novel zone, hab. session 2	0.3	0.3	0.4	-0.6	0.4	0.5
Total zone transitions, hab. session 2	0.1	0.1	0.2	0.3	0.1	-0.5
Total locomotion distance, hab. session 2	0.1	0.2	0.3	0.5	-0.1	-0.5
Locomotion velocity, hab. session 2	0.3	0.4	0.6	0.7	-0.3	-0.8
Novel to familiar place preference ratio	0.9	0.9	1.2	-1.0	1.1	0.7
Novelty place preference	1.4	1.4	1.7	-1.3	1.3	1.0
Time in novel zone, NPP test	1.6	1.6	1.9	-1.4	1.3	1.1
Total zone transitions, NPP test	1.2	1.8	2.0	1.4	-1.2	-1.3
Total locomotion distance, NPP test	1.8	2.5	2.7	1.7	-1.6	-1.5
Locomotion velocity, NPP test	3.0	4.3	4.7	2.2	-1.9	-2.1
Intraocular pressure	5.0	7.0	9.4	-2.6	3.1	2.1
Delta distance traveled before/after self-admin	1.5	1.6	1.8	-1.3	1.3	1.3
Delta ambulatory time before/after self-admin	0.3	0.3	0.4	-0.5	0.6	0.6
Parametrial fat weight	6.3	12.2	14.2	-3.4	3.8	3.2
Pavlov. Cond. lever latency	1.5	1.9	2.1	-1.5	1.2	1.5
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	0.1	-0.1	-0.1
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	0.2	-0.1	-0.2
Pavlov. Cond. index score	0.6	0.7	0.9	0.9	-0.7	-1.0
Pavlov. Cond. latency score	0.5	0.7	0.8	0.9	-0.6	-0.9
Pavlov. Cond. lever contacts	0.9	1.1	1.4	1.1	-0.8	-1.2
Pavlov. Cond. magazine entry number	0.3	0.4	0.5	-0.7	0.6	0.7
Pavlov. Cond. intertrial magazine entries	1.3	1.6	1.8	1.3	-1.2	-1.3
Pavlov. Cond. lever-magazine prob. diff.	1.4	1.8	2.2	1.4	-1.1	-1.5
Pavlov. Cond. response bias	1.4	1.7	1.9	1.3	-1.2	-1.4
Pavlov. Cond. lever latency	1.6	2.2	2.5	-1.6	1.3	1.6
Pavlov. Cond. magazine entry latency	0.2	0.2	0.3	0.5	-0.5	-0.4
Pavlov. Cond. change in total contacts	0.6	0.8	1.0	0.9	-0.7	-1.0
Pavlov. Cond. index score	1.0	1.2	1.4	1.2	-1.0	-1.1
Pavlov. Cond. latency score	0.9	1.2	1.3	1.1	-1.0	-1.0
Pavlov. Cond. lever contacts	0.8	1.1	1.5	1.1	-0.8	-1.2
Pavlov. Cond. magazine entry number	0.1	0.1	0.1	-0.3	0.2	0.3
Pavlov. Cond. intertrial magazine entries	3.1	4.1	4.3	-2.1	1.9	2.1
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	0.9	1.0	-0.8	-0.9
Pavlov. Cond. response bias	1.5	2.1	2.6	1.5	-1.2	-1.6
Time in closed arm before self-admin	0.5	0.5	0.7	-0.7	0.6	0.9
Time in closed arm after self-admin	1.2	1.2	1.5	-1.2	0.9	1.2
Time in open arm before self-admin	0.1	0.1	0.3	0.2	0.4	-0.5
Time in open arm after self-admin	1.9	2.1	2.7	1.5	-1.1	-1.6
Bone: periosteal estimation	0.5	0.9	1.1	1.0	-0.8	-1.0
Bone: periosteal perimeter	0.1	0.2	0.4	0.5	-0.2	-0.6
Bone: post-yield work	0.4	0.5	0.6	0.7	-0.8	-0.6
Progressive ratio test 1 active lever presses	1.4	1.5	2.9	1.1	-1.7	-0.6
Progressive ratio test 1 breakpoint	1.3	1.3	2.6	1.0	-1.6	-0.6
Progressive ratio test 1 inactive lever presses	3.6	4.0	7.4	1.8	-2.7	-1.1
Progressive ratio test 2 active lever presses	0.1	0.1	0.3	0.1	-0.6	0.3
Progressive ratio test 2 breakpoint	0.2	0.2	0.5	0.2	-0.7	0.2
Progressive ratio test 2 inactive lever presses	1.7	2.0	3.5	1.3	-1.9	-0.8
Incentive Sensitization - Responses	0.1	0.1	0.2	-0.3	0.2	0.5
Incentive Sensitization - Breakpoint	0.3	0.3	0.6	-0.5	0.4	0.7
Sum of active levers in priming session hrs 5-6	0.9	0.9	1.4	1.0	-0.6	-1.2
Progressive ratio	0.1	0.1	0.3	0.0	-0.6	0.3
Food seeking constrained by brief footshock	4.2	5.2	8.3	2.1	-2.9	-1.7
Seeking ratio, punishment vs. effort	0.7	0.8	1.2	0.9	-0.6	-1.1
Retroperitoneal fat weight	21.4	70.3	72.3	-8.5	8.2	8.5
Reaction time number correct	0.5	0.7	0.9	0.9	-0.7	-1.0
Reaction time mean minus median	0.0	0.0	0.0	-0.1	-0.2	0.1
Reaction time mean minus median AUC	0.0	0.0	0.1	-0.2	0.1	0.2
Reaction time num false alarms	0.1	0.2	0.5	0.3	0.1	-0.7
Reaction time num false alarms AUC	0.2	0.3	0.6	0.4	0.1	-0.8
Reaction time trials correct on left	0.5	0.7	0.9	0.9	-0.7	-1.0
Reaction time trials on left	0.5	0.8	1.0	0.9	-0.7	-1.0
Reaction time mean	1.1	1.6	1.7	-1.3	1.2	1.2
Reaction time mean AUC	0.9	1.3	1.4	-1.2	1.1	1.1
Median of all reaction times	1.3	1.7	2.0	-1.3	1.4	1.2
Reaction time omissions	0.0	0.1	0.1	0.3	-0.2	-0.2
Reaction time false alarm rate	0.1	0.1	0.3	-0.1	0.5	-0.2
Reaction time premature initiation rate	0.2	0.2	0.3	-0.5	0.5	0.4
Reaction time premature initiations	0.0	0.0	0.0	0.0	0.1	-0.2
Std. dev. reaction times	0.3	0.5	0.6	-0.7	0.6	0.7
Reaction time trials completed	0.5	0.8	1.0	0.9	-0.7	-1.0
Reaction time trials AUC	0.7	1.0	1.3	1.0	-0.9	-1.1
Run reversals in cocaine runway, females	0.1	0.1	0.1	-0.2	0.3	-0.3
Run reversals in cocaine runway, males	0.5	0.4	0.9	0.5	-0.4	-1.0
Latency to leave start box in cocaine runway	0.4	0.4	0.6	0.8	-0.7	-0.5
Latency to leave start box in cocaine runway, F	0.5	0.5	0.7	0.8	-0.6	-0.8
Latency to leave start box in cocaine runway, M	0.6	0.5	1.1	0.7	-1.0	-0.2
Std. dev. time between licks in bursts	0.3	0.3	0.6	-0.4	0.8	0.4
Total sessions with >9 infusions	2.4	2.6	4.7	1.4	-2.2	-1.0
Short access day 1 total inactive lever presses	4.4	4.9	5.4	2.2	-2.3	-2.1
Short access day 10 total inactive lever presses	1.0	1.1	1.2	1.0	-1.1	-1.0
Short access day 1 total infusions	4.5	4.8	7.3	2.1	-2.7	-1.6
Short access day 10 total infusions	3.8	4.2	5.5	2.0	-2.4	-1.8
Short access total infusions	2.8	3.1	5.0	1.7	-2.2	-1.3
Short access day 1 locomotion	6.5	6.9	10.0	2.6	-3.2	-2.1
Short access day 10 total locomotion	0.6	0.7	1.0	0.9	-1.0	-0.5
Short access total locomotion	0.5	0.6	1.2	0.7	-1.1	-0.3
One hour access (0.3 mA shock)	1.6	1.8	2.1	1.4	-1.4	-1.2
Compulsive drug intake	0.4	0.4	1.1	-0.5	1.0	-0.0
One hour access (shock baseline)	1.6	1.9	3.0	1.3	-1.7	-0.9
Social response proportion	0.5	0.5	0.6	-0.6	0.6	0.8
Social responses	0.2	0.2	0.3	-0.4	0.5	0.6
Social time	0.8	1.0	1.9	-0.9	0.6	1.4
Soleus weight	4.3	12.6	15.2	3.6	-3.1	-3.9
Bone: stiffness	0.0	0.1	0.1	-0.2	0.3	0.3
Tibialis anterior weight	3.6	12.1	12.9	3.5	-3.3	-3.6
Time to tail flick, vehicle, before self-admin	2.3	2.3	2.7	-1.6	1.3	1.7
Time to tail flick, vehicle, after self-admin	4.3	4.6	5.3	-2.2	1.9	2.3
Time to tail flick, test, before self-admin	0.6	0.6	0.7	0.7	-0.9	-0.6
Time to tail flick, test, after self-admin	0.1	0.1	0.1	-0.3	0.2	0.4
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.1	-0.2	0.2	0.3
Delta time to tail flick, test, before/after SA	0.2	0.2	0.3	0.5	-0.4	-0.5
Tibia length	2.6	7.3	7.9	-2.7	2.6	2.8
Ambulatory time before self-admin	0.1	0.1	0.3	0.4	-0.1	-0.5
Ambulatory time after self-admin	0.5	0.6	1.0	-0.7	1.0	0.5
Bone: tissue strength	0.8	0.8	1.1	-0.9	1.0	0.8
Total heroin consumption	2.9	3.4	3.7	1.9	-1.7	-1.9
Bone: trabecular number	3.7	5.8	6.5	2.5	-2.1	-2.6
Bone: trabecular spacing	2.8	3.6	4.1	-2.0	1.8	1.8
Bone: trabecular thickness	0.6	0.7	0.8	0.9	-0.8	-0.8
Bone: trabecular tissue density	0.2	0.2	0.3	0.4	-0.6	-0.3
Water consumed over 24 hours	1.2	1.4	2.2	1.3	-0.6	-1.5
Number of responses in last shaping day	0.4	0.4	0.7	0.5	-0.9	-0.5