Hub : Genes

Tectb

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Eye gene expression Tectb 0.33 0.2 3.0e-03 0.13 0.19 0.14 0.17 4.6e-03 8.2e-04 4.1e-03 1.5e-03
2 PL gene expression Tectb 0.03 0.03 3.4e-03 0.03 0.02 0.01 0.02 8.3e-04 4.3e-03 9.7e-03 5.5e-03
3 Adipose gene expression Tectb 0.12 0.07 2.2e-10 0.07 0.03 0.08 0.05 5.9e-08 3.8e-04 2.0e-09 7.5e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bone: apparent density1.32.14.31.4-2.1-0.2
Area under the delay curve0.91.02.10.5-1.4-0.8
BMI with tail5.016.331.05.6-2.03.8
BMI without tail2.24.57.12.7-1.81.8
Body weight6.125.751.27.2-2.34.5
Weight adjusted by age3.74.26.92.60.02.4
Bone surface0.30.51.01.0-0.70.1
Bone volume1.52.55.02.2-1.50.6
Breakpoint value in progressive ratio session1.31.42.70.0-1.6-1.2
Number of licking bursts1.01.22.90.3-1.7-0.7
Context. condit. distance diff. score0.60.71.0-0.41.01.0
Locomotion velocity, session 12.42.64.1-1.8-0.7-2.0
Locomotion distance, session 10.10.20.3-0.50.50.1
Locomotion velocity, session 21.11.23.1-0.41.70.7
Locomotion distance, session 20.91.32.41.5-0.61.1
Locomotion velocity, session 30.10.10.30.00.30.6
Locomotion distance, session 31.31.53.80.50.61.9
Stereotopy head waving bouts, day 30.10.10.30.3-0.50.1
Stereotopy head waving duration, day 30.91.01.5-1.2-0.5-1.2
Locomotion velocity, session 70.00.00.10.1-0.4-0.1
Locomotion distance, session 70.10.10.30.00.50.3
Stereotopy head waving bouts, day 70.10.10.2-0.0-0.5-0.2
Stereotopy head waving duration, day 70.20.30.70.4-0.8-0.1
Locomotion velocity, session 80.60.81.3-1.10.8-0.7
Locomotion distance, session 80.40.50.9-0.10.80.9
Degree of sensitization distance1.71.84.1-1.0-0.3-2.0
Degree of sensitization stereotypy0.10.20.40.1-0.6-0.3
Conditioned locomotion0.00.00.10.00.20.0
Cocaine response after cond. corrected0.91.01.5-1.01.20.6
Cocaine response after cond. not corrected1.21.32.4-1.61.2-0.2
Cocaine response before conditioning1.11.32.9-0.9-0.5-1.7
Saline control response0.20.30.5-0.50.70.1
Bone: connectivity density0.10.10.2-0.3-0.3-0.5
Bone: cortical apparent density3.34.39.7-0.53.11.7
Bone: cortical area3.85.79.43.1-2.31.5
Bone: cortical porosity0.80.91.9-0.0-1.4-0.8
Bone: cortical porosity1.21.33.00.3-1.7-0.8
Bone: cortical thickness2.23.56.12.5-1.21.8
Bone: cortical thickness1.51.72.91.7-0.21.5
Bone: cortical tissue density3.34.410.0-0.73.21.6
Condit. Reinf. active minus inactive responses0.40.50.7-0.9-0.80.1
Condit. Reinf. active-inactive response ratio0.50.61.4-1.2-0.5-0.2
Condit. Reinf. active responses0.81.03.0-0.1-1.70.2
Condit. Reinf. inactive responses1.11.33.60.4-1.9-0.1
Incentive salience index mean0.70.82.0-1.4-0.7-0.3
Condit. Reinf. lever presses0.71.01.7-1.3-0.5-1.0
Condit. Reinf. active minus inactive responses3.44.28.3-1.5-2.9-1.4
Condit. Reinf. active-inactive response ratio2.32.43.2-1.7-1.8-1.1
Condit. Reinf. active responses3.04.210.2-0.7-3.2-1.4
Condit. Reinf. inactive responses0.81.02.50.4-1.6-0.6
Condit. Reinf. lever presses1.72.34.1-0.7-2.0-1.5
Condit. Reinf. lever reinforcers received2.84.09.2-0.8-3.0-1.4
Conditioned reinforcement - actives0.10.10.3-0.60.1-0.3
Conditioned reinforcement - inactives0.50.51.30.5-1.1-0.3
Conditioned locomotion0.50.61.2-0.40.6-1.1
Patch foraging indifference point 0 sec1.82.85.02.2-1.51.1
Patch foraging indifference point AUC2.22.64.30.4-2.1-1.8
Delay disc. indifference point, 0s delay0.50.61.31.2-0.70.1
Delay disc. indifference point, 16s delay1.11.12.1-0.3-1.1-1.4
Delay disc. indifference point, 2s delay0.10.10.20.4-0.10.1
Delay disc. indifference point, 24s delay2.62.54.10.2-2.0-1.8
Delay disc. indifference point, 4s delay0.30.40.8-0.3-0.9-0.4
Delay disc. indifference point, 8s delay1.81.93.61.3-1.9-0.6
Indifference point function ln k0.71.01.6-0.21.31.1
Indifference point function log k0.71.01.6-0.21.31.1
Patch foraging total patch changes 0 sec1.72.84.62.2-1.80.8
Patch foraging total patch changes 12 sec1.62.15.00.9-2.2-0.6
Patch foraging total patch changes 18 sec3.44.49.71.5-3.1-1.1
Patch foraging total patch changes 24 sec4.45.412.20.7-3.5-1.9
Patch foraging total patch changes 6 sec2.43.65.32.3-2.30.4
Patch foraging time to switch 0 sec0.50.81.1-1.11.00.2
Patch foraging water rate 0 sec0.40.71.41.2-0.80.2
Patch foraging water rate 12 sec0.60.91.41.1-1.20.3
Patch foraging water rate 18 sec0.70.91.41.2-0.21.2
Patch foraging water rate 24 sec1.31.83.41.9-1.01.0
Patch foraging water rate 6 sec0.50.81.11.00.31.1
Seeking ratio, delayed vs. immediate footshock0.00.00.1-0.00.0-0.4
Distance traveled before self-admin2.62.75.80.22.41.5
Distance traveled after self-admin2.93.34.91.42.21.7
Extensor digitorum longus weight0.41.42.31.5-1.30.5
Bone: elastic displacement0.10.10.4-0.1-0.6-0.1
Bone: elastic work1.31.72.71.50.41.6
Bone: endosteal estimation0.92.03.61.9-1.50.6
Bone: endosteal perimeter1.53.15.62.4-1.31.3
Epididymis fat weight7.216.833.75.8-3.32.5
Delta time in closed arm before/after self-admin1.01.01.50.11.21.2
Delta time in open arm before/after self-admin1.51.52.20.3-1.5-1.5
Diff in mean of infusions in LGA sessions1.31.53.9-2.0-0.1-0.7
Delay discount exponential model param1.11.12.4-0.61.60.8
Extinction: sum of active levers before priming1.51.42.8-0.4-1.2-1.7
Active lever presses in extinction session 60.40.40.50.6-0.7-0.4
Bone: final force1.01.53.01.7-1.00.8
Bone: final moment1.32.14.02.0-1.21.0
Food consumed during 24 hour testing period0.30.41.10.1-0.21.0
Glucose2.63.97.62.80.12.0
Heart weight1.72.44.61.4-0.62.1
Delay discount hyperbolic model param0.70.71.6-0.51.20.5
Intermittent access intake day 1-15 change1.61.63.01.3-1.70.2
Intermittent access intake escalation1.91.93.31.8-1.11.1
Intermittent access intake escalation 21.11.12.11.5-0.80.7
Intermitt. access day 1 inactive lever presses1.61.73.71.1-1.9-0.5
Intermitt. access day 15 inactive lever presses0.20.20.5-0.2-0.7-0.2
Intermitt. access escalation Index0.20.20.30.50.50.3
Intermittent access day 1 total infusions1.11.32.0-0.2-1.4-1.3
Intermittent access day 15 total infusions1.41.64.00.9-2.0-0.2
Intermittent access terminal intake (last 3 days)0.91.02.40.4-1.5-0.7
Intermittent access total infusions1.21.32.90.4-1.7-0.9
Intermittent access day 1 locomotion0.10.10.30.00.50.2
Intermittent access day 15 total locomotion0.80.91.61.3-1.00.1
Intermittent access total locomotion0.10.10.30.50.40.1
Intermittent access standard deviation2.93.06.20.7-2.5-1.6
Left kidney weight4.512.518.84.11.44.3
Right kidney weight4.111.517.74.20.34.1
Cocaine induced anxiety2.83.27.8-1.32.80.3
Post-drug Anxiety0.50.61.6-0.31.30.3
Baseline Anxiety3.94.17.72.1-2.8-0.3
Tail length0.20.71.80.6-1.30.1
Length with tail1.45.110.73.3-1.01.9
Length without tail3.68.016.74.1-0.52.6
Times rat made contact with spout1.01.22.21.5-0.80.8
Lifetime Intake1.31.53.40.4-1.8-1.0
Liver weight, left2.33.65.82.2-2.4-0.5
Liver weight, right4.57.516.74.1-1.71.7
Locomotor activity1.01.72.81.40.61.7
Locomotor testing distance2.23.65.71.71.52.4
Locomotor testing rearing0.91.42.01.20.71.4
Locomotion in novel chamber1.41.83.20.61.31.8
Locomotion in novel chamber post-restriction0.40.50.8-0.90.70.2
Fecal boli incidents, locomotor time 10.20.20.4-0.2-0.6-0.6
Change in fecal boli incidents, locomotor task0.10.10.2-0.4-0.00.2
Time >=10cm from walls, locomotor time 10.40.40.7-0.80.6-0.4
Bouts of movement, locomotor time 12.12.35.10.7-2.3-1.2
Total resting periods, locomotor time 11.82.04.40.7-2.1-1.0
Rest time, locomotor task time 10.20.20.40.6-0.00.4
Distance moved, locomotor task time 10.00.00.00.20.20.0
Vertical activity count, locomotor time 11.31.32.3-0.41.51.2
Time >=10cm from walls, locomotor time 20.30.30.50.7-0.6-0.3
Bouts of movement, locomotor time 20.60.61.3-1.10.1-0.8
Total resting periods, locomotor time 20.40.40.6-0.8-0.1-0.7
Rest time, locomotor task time 20.30.30.70.20.90.4
Distance moved, locomotor task time 20.70.81.7-0.0-1.3-0.8
Vertical activity count, locomotor time 20.10.10.20.4-0.50.0
Light reinforcement 10.61.12.0-1.4-0.0-1.1
Light reinforcement 20.81.02.0-1.40.4-0.9
Bone: marrow area1.02.23.82.0-1.50.6
Bone: maximum diameter3.05.59.93.1-2.50.8
Bone: maximum force0.91.52.41.5-0.91.1
Bone: maximum moment1.22.13.21.8-1.21.2
Mean time between licks in bursts0.60.82.1-0.3-1.5-0.4
Mean num. licks in bursts1.61.92.91.01.31.7
Cd content in liver1.71.94.2-2.00.3-1.2
Co content in liver0.50.61.40.21.20.6
Cu content in liver0.30.30.40.60.50.6
Fe content in liver0.00.10.10.4-0.10.1
K content in liver0.50.51.6-0.1-0.1-1.3
Mg content in liver1.21.22.5-0.1-1.1-1.6
Mn content in liver0.20.20.3-0.50.60.0
Na content in liver1.71.83.0-1.4-0.7-1.7
Rb content in liver1.82.23.5-1.3-1.2-1.9
Se content in liver0.91.12.0-1.20.2-1.4
Sr content in liver1.21.11.8-1.21.4-0.1
Zn content in liver1.31.42.8-1.21.70.2
Bone: minimum diameter1.93.55.72.4-1.71.3
Time in familiar zone, hab. session 11.41.33.2-0.41.80.8
Time in novel zone, hab. session 11.51.53.60.5-1.9-0.8
Total zone transitions, hab. session 11.01.42.41.6-0.31.3
Total locomotion distance, hab. session 10.10.20.50.2-0.7-0.2
Locomotion velocity, hab. session 10.10.20.50.1-0.7-0.2
Time in familiar zone, hab. session 22.02.04.71.2-2.2-0.1
Time in novel zone, hab. session 21.31.33.1-0.51.80.7
Total zone transitions, hab. session 21.62.13.11.8-0.61.7
Total locomotion distance, hab. session 20.91.21.91.4-0.71.1
Locomotion velocity, hab. session 20.50.71.11.1-0.40.8
Novel to familiar place preference ratio0.30.30.5-0.2-0.7-0.6
Novelty place preference0.30.30.4-0.1-0.7-0.6
Time in novel zone, NPP test0.60.61.40.2-1.2-0.6
Total zone transitions, NPP test1.31.83.01.7-1.30.9
Total locomotion distance, NPP test1.11.52.31.3-1.50.6
Locomotion velocity, NPP test0.50.71.11.0-0.80.7
Intraocular pressure2.53.56.91.7-2.60.8
Delta distance traveled before/after self-admin1.01.12.81.7-0.10.6
Delta ambulatory time before/after self-admin1.01.12.01.4-1.1-0.2
Parametrial fat weight4.17.913.63.7-3.10.6
Pavlov. Cond. lever latency0.30.40.70.8-0.80.1
Pavlov. Cond. magazine entry latency0.30.40.70.8-0.60.3
Pavlov. Cond. change in total contacts0.10.10.20.20.40.3
Pavlov. Cond. index score0.20.20.40.60.10.4
Pavlov. Cond. latency score0.10.10.20.50.20.3
Pavlov. Cond. lever contacts0.20.30.5-0.70.3-0.4
Pavlov. Cond. magazine entry number0.91.12.1-1.40.4-1.1
Pavlov. Cond. intertrial magazine entries0.10.10.30.3-0.30.5
Pavlov. Cond. lever-magazine prob. diff.0.10.10.30.5-0.00.2
Pavlov. Cond. response bias0.10.10.20.40.10.5
Pavlov. Cond. lever latency3.14.16.60.82.62.3
Pavlov. Cond. magazine entry latency1.21.42.71.1-1.7-0.4
Pavlov. Cond. change in total contacts2.33.17.6-0.1-2.8-1.3
Pavlov. Cond. index score2.02.56.00.3-2.5-1.2
Pavlov. Cond. latency score2.02.55.90.4-2.4-1.3
Pavlov. Cond. lever contacts1.41.93.9-0.3-2.0-1.3
Pavlov. Cond. magazine entry number1.31.63.8-0.91.90.4
Pavlov. Cond. intertrial magazine entries0.00.10.1-0.10.30.3
Pavlov. Cond. lever-magazine prob. diff.1.72.15.20.3-2.3-1.1
Pavlov. Cond. response bias1.62.25.50.1-2.3-1.1
Time in closed arm before self-admin0.20.20.30.30.40.5
Time in closed arm after self-admin0.50.50.7-0.50.80.8
Time in open arm before self-admin0.80.91.6-1.30.3-1.0
Time in open arm after self-admin2.42.75.5-0.7-1.4-2.3
Bone: periosteal estimation2.96.010.93.3-2.21.5
Bone: periosteal perimeter4.06.612.33.5-2.11.8
Bone: post-yield work0.70.92.0-0.5-1.4-0.6
Progressive ratio test 1 active lever presses0.20.20.60.3-0.8-0.1
Progressive ratio test 1 breakpoint0.30.40.8-0.2-0.9-0.5
Progressive ratio test 1 inactive lever presses0.80.92.0-0.0-1.4-0.8
Progressive ratio test 2 active lever presses0.90.91.91.0-1.4-0.1
Progressive ratio test 2 breakpoint1.01.12.60.9-1.6-0.3
Progressive ratio test 2 inactive lever presses1.01.22.70.3-1.6-0.9
Incentive Sensitization - Responses0.80.82.00.6-1.4-0.4
Incentive Sensitization - Breakpoint0.90.92.20.6-1.5-0.5
Sum of active levers in priming session hrs 5-61.11.11.8-1.20.1-1.3
Progressive ratio0.91.01.9-1.4-0.5-0.9
Food seeking constrained by brief footshock1.72.12.9-1.1-1.7-1.5
Seeking ratio, punishment vs. effort0.20.20.40.6-0.50.2
Retroperitoneal fat weight7.023.046.76.8-2.73.9
Reaction time number correct1.01.42.51.3-1.60.0
Reaction time mean minus median0.10.10.20.40.0-0.2
Reaction time mean minus median AUC0.40.50.80.90.60.5
Reaction time num false alarms0.20.20.5-0.1-0.7-0.5
Reaction time num false alarms AUC0.00.00.10.0-0.3-0.2
Reaction time trials correct on left1.01.42.51.3-1.60.0
Reaction time trials on left1.01.42.51.3-1.60.1
Reaction time mean0.40.61.60.11.30.3
Reaction time mean AUC0.40.61.7-0.31.3-0.0
Median of all reaction times0.71.02.80.11.70.5
Reaction time omissions0.00.10.10.2-0.10.4
Reaction time false alarm rate0.20.30.6-0.80.2-0.4
Reaction time premature initiation rate1.11.52.11.51.11.1
Reaction time premature initiations1.72.35.32.30.21.3
Std. dev. reaction times0.30.41.01.00.20.4
Reaction time trials completed1.01.42.51.3-1.60.1
Reaction time trials AUC1.11.52.71.3-1.70.1
Run reversals in cocaine runway, females1.21.21.31.11.01.1
Run reversals in cocaine runway, males1.31.32.3-1.50.2-1.2
Latency to leave start box in cocaine runway0.40.40.6-0.80.7-0.5
Latency to leave start box in cocaine runway, F1.01.02.6-0.71.60.2
Latency to leave start box in cocaine runway, M0.30.30.60.0-0.8-0.5
Std. dev. time between licks in bursts1.82.13.6-0.8-1.9-1.4
Total sessions with >9 infusions2.02.24.62.2-0.41.3
Short access day 1 total inactive lever presses0.70.81.31.2-1.0-0.2
Short access day 10 total inactive lever presses0.40.51.10.6-1.00.1
Short access day 1 total infusions0.20.30.60.8-0.40.0
Short access day 10 total infusions0.60.71.1-0.4-1.0-0.9
Short access total infusions0.70.81.80.2-1.4-0.8
Short access day 1 locomotion0.30.30.50.3-0.7-0.6
Short access day 10 total locomotion1.51.72.11.21.51.2
Short access total locomotion0.80.81.00.90.81.0
One hour access (0.3 mA shock)3.54.18.10.8-2.8-1.9
Compulsive drug intake1.01.01.5-0.5-1.2-1.2
One hour access (shock baseline)0.50.61.11.1-0.9-0.2
Social response proportion3.03.24.82.10.62.2
Social responses2.22.84.92.2-1.80.4
Social time1.11.42.91.70.41.1
Soleus weight3.39.618.94.4-0.13.1
Bone: stiffness0.10.20.40.5-0.30.6
Tibialis anterior weight0.20.81.6-0.3-1.3-0.8
Time to tail flick, vehicle, before self-admin0.80.81.71.3-0.90.1
Time to tail flick, vehicle, after self-admin0.20.20.30.40.60.3
Time to tail flick, test, before self-admin2.62.63.61.41.51.9
Time to tail flick, test, after self-admin0.70.81.71.3-0.70.3
Delta time to tail flick, vehicle, before/after SA0.10.10.2-0.30.40.1
Delta time to tail flick, test, before/after SA0.70.71.60.5-1.2-0.4
Tibia length1.23.35.42.30.82.0
Ambulatory time before self-admin3.23.35.10.82.32.1
Ambulatory time after self-admin2.93.24.61.72.11.5
Bone: tissue strength0.30.30.5-0.7-0.3-0.4
Total heroin consumption1.01.23.00.7-1.70.0
Bone: trabecular number0.60.92.30.3-1.5-0.5
Bone: trabecular spacing0.10.20.3-0.60.0-0.5
Bone: trabecular thickness2.73.26.12.5-1.90.2
Bone: trabecular tissue density0.40.61.30.21.10.7
Water consumed over 24 hours0.91.11.71.20.41.3
Number of responses in last shaping day0.30.30.60.40.30.8