Hub : Genes

Abhd1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA gene expression Abhd1 0.1 0.07 5.1e-05 0.08 0.07 0.06 0.06 2.6e-04 3.7e-04 8.7e-04 2.0e-03
2 Liver gene expression Abhd1 0.03 0.03 6.8e-03 0.02 0.02 0.01 0.02 5.7e-03 5.0e-03 2.1e-02 6.0e-03
3 Adipose mRNA stability Abhd1 0.09 0.1 5.1e-07 0.06 0.05 0.06 0.05 1.0e-06 1.3e-06 8.2e-07 1.1e-06
4 PL gene expression Abhd1 0.2 0.24 8.1e-07 0.06 0.06 0.06 0.06 1.4e-07 8.6e-07 1.3e-07 2.7e-07
5 BLA gene expression Abhd1 0.11 0.12 1.9e-03 0.04 0.04 0.02 0.03 4.7e-03 3.6e-03 2.7e-02 9.0e-03
6 NAcc gene expression Abhd1 0.08 0.07 2.9e-05 0.03 0.04 0.03 0.03 6.5e-04 2.8e-05 9.6e-05 1.7e-04
7 Liver mRNA stability Abhd1 0.02 0.03 5.8e-03 0.01 0.01 0.01 0.01 9.0e-03 1.5e-02 9.5e-03 1.6e-02
8 Liver isoform ratio XM_039112176.1 0.06 0.05 1.9e-05 0.04 0.03 0.03 0.03 9.1e-05 1.9e-04 1.1e-04 1.8e-04
9 Liver isoform ratio NM_001008520.1 0.06 0.06 1.1e-05 0.04 0.03 0.04 0.04 4.0e-05 1.2e-04 4.6e-05 7.1e-05
10 Brain gene expression Abhd1 0.03 0.02 1.3e-03 0.02 0.02 0.02 0.02 3.3e-03 4.3e-03 7.7e-03 1.0e-02
11 PL intron excision ratio chr6_25423988_25424131 0.16 0.16 5.6e-03 0.01 0.01 0.01 0.01 1.4e-02 1.3e-02 1.0e-02 1.9e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density4.57.610.43.02.9-3.23.0-2.6-2.5-3.22.4-2.42.6-2.0
Area under the delay curve0.10.10.30.0-0.10.30.20.10.20.3-0.60.6-0.20.4
BMI with tail0.72.44.4-1.2-1.41.8-1.11.92.11.6-1.91.9-1.1-0.0
BMI without tail0.20.30.8-0.5-0.60.9-0.40.60.60.8-0.50.5-0.40.1
Body weight1.87.59.4-2.7-2.92.7-2.53.03.02.6-3.13.1-2.61.6
Weight adjusted by age0.20.21.90.00.00.20.20.00.10.20.5-0.50.3-1.4
Bone surface2.23.96.32.32.1-2.42.3-1.5-1.3-2.51.6-1.61.7-2.0
Bone volume2.44.16.92.32.2-2.62.3-1.8-1.6-2.61.6-1.61.8-1.5
Breakpoint value in progressive ratio session1.31.42.21.01.1-1.51.4-1.2-1.3-1.50.9-0.91.1-1.1
Number of licking bursts0.10.20.70.1-0.10.10.20.60.8-0.1-0.30.3-0.3-0.7
Context. condit. distance diff. score0.00.00.20.0-0.0-0.1-0.1-0.1-0.1-0.10.1-0.1-0.20.4
Locomotion velocity, session 10.20.20.40.0-0.20.5-0.10.60.70.4-0.60.6-0.2-0.3
Locomotion distance, session 11.31.62.71.61.4-1.31.6-0.9-0.7-1.31.1-1.11.1-1.6
Locomotion velocity, session 20.20.30.5-0.5-0.50.5-0.50.50.50.5-0.40.4-0.70.6
Locomotion distance, session 20.00.00.30.1-0.00.10.10.20.30.00.0-0.00.0-0.5
Locomotion velocity, session 30.91.12.50.80.9-0.80.7-0.8-0.8-0.81.3-1.31.3-1.6
Locomotion distance, session 30.91.03.11.10.9-0.70.9-0.5-0.4-0.81.0-1.01.0-1.8
Stereotopy head waving bouts, day 31.92.33.11.51.6-1.31.5-1.7-1.8-1.21.5-1.51.8-1.0
Stereotopy head waving duration, day 30.20.30.70.30.5-0.30.5-0.7-0.8-0.20.5-0.50.7-0.0
Locomotion velocity, session 71.11.22.31.11.0-1.21.2-0.7-0.6-1.30.8-0.81.1-1.5
Locomotion distance, session 70.20.21.30.30.1-0.30.40.40.5-0.50.1-0.10.1-1.1
Stereotopy head waving bouts, day 70.10.10.3-0.1-0.10.5-0.20.10.10.6-0.20.2-0.10.2
Stereotopy head waving duration, day 70.30.40.70.60.7-0.40.7-0.8-0.8-0.40.6-0.60.8-0.4
Locomotion velocity, session 80.30.40.60.60.6-0.80.8-0.7-0.7-0.70.6-0.60.4-0.3
Locomotion distance, session 80.20.30.70.80.7-0.70.7-0.5-0.4-0.70.5-0.50.3-0.3
Degree of sensitization distance0.80.81.1-0.9-0.90.8-0.71.01.00.7-1.01.0-1.10.8
Degree of sensitization stereotypy0.30.30.6-0.5-0.50.8-0.50.50.50.8-0.50.5-0.50.2
Conditioned locomotion3.44.04.91.92.0-2.02.0-2.2-2.2-1.92.1-2.12.1-1.1
Cocaine response after cond. corrected0.40.41.01.00.8-0.70.9-0.6-0.5-0.7-0.10.10.4-0.2
Cocaine response after cond. not corrected1.01.12.01.41.3-1.21.3-1.1-1.0-1.20.5-0.50.9-0.5
Cocaine response before conditioning1.62.03.51.21.3-1.21.1-1.6-1.6-1.11.9-1.91.4-0.7
Saline control response0.81.01.31.11.1-1.11.1-1.0-1.0-1.11.1-1.10.9-0.5
Bone: connectivity density4.36.89.22.82.7-3.02.8-2.3-2.2-3.02.4-2.42.5-2.4
Bone: cortical apparent density0.40.51.10.60.6-0.60.7-0.4-0.4-0.71.0-1.00.5-0.6
Bone: cortical area0.30.41.20.70.5-1.00.7-0.10.1-1.10.3-0.30.2-1.1
Bone: cortical porosity2.12.33.31.31.5-1.71.4-1.7-1.8-1.61.5-1.51.5-0.7
Bone: cortical porosity1.61.72.41.21.3-1.61.2-1.5-1.6-1.51.2-1.21.3-0.4
Bone: cortical thickness0.10.20.6-0.1-0.3-0.0-0.20.60.8-0.1-0.50.5-0.7-0.0
Bone: cortical thickness1.31.52.11.51.3-1.31.4-1.0-0.9-1.41.2-1.20.9-1.4
Bone: cortical tissue density0.30.30.90.50.5-0.50.6-0.3-0.3-0.60.9-0.90.4-0.6
Condit. Reinf. active minus inactive responses0.91.11.6-0.9-1.01.1-0.91.21.21.0-1.31.3-0.90.3
Condit. Reinf. active-inactive response ratio0.80.81.1-1.0-1.01.0-1.01.01.00.9-0.90.9-0.70.3
Condit. Reinf. active responses0.10.10.10.40.2-0.00.40.00.1-0.1-0.40.40.2-0.3
Condit. Reinf. inactive responses1.01.22.21.51.3-1.11.5-1.1-1.0-1.00.6-0.61.1-0.7
Incentive salience index mean0.10.10.30.0-0.00.00.00.20.3-0.0-0.50.5-0.0-0.2
Condit. Reinf. lever presses0.30.40.60.80.8-0.70.7-0.7-0.6-0.70.1-0.10.60.0
Condit. Reinf. active minus inactive responses3.94.87.12.12.2-1.82.2-2.1-2.1-1.82.4-2.42.4-2.7
Condit. Reinf. active-inactive response ratio0.80.81.11.01.0-0.50.9-1.0-1.0-0.50.8-0.81.1-0.8
Condit. Reinf. active responses3.34.57.51.92.0-1.82.1-2.0-1.9-1.82.3-2.32.3-2.7
Condit. Reinf. inactive responses1.92.34.41.31.4-1.61.5-1.3-1.2-1.61.6-1.61.5-2.1
Condit. Reinf. lever presses1.92.63.61.61.6-1.31.7-1.6-1.5-1.31.9-1.91.6-1.4
Condit. Reinf. lever reinforcers received3.04.27.31.81.9-1.62.0-1.9-1.9-1.72.3-2.32.3-2.7
Conditioned reinforcement - actives2.32.33.81.71.4-1.61.4-1.8-1.9-1.51.5-1.51.4-0.5
Conditioned reinforcement - inactives3.13.54.72.02.0-1.91.7-2.2-2.1-1.81.9-1.91.8-0.3
Conditioned locomotion1.11.43.41.00.9-0.91.1-1.5-1.9-0.81.3-1.31.2-0.1
Patch foraging indifference point 0 sec0.30.50.8-0.9-0.80.4-0.70.90.90.3-0.80.8-0.8-0.2
Patch foraging indifference point AUC2.32.65.11.81.6-1.91.8-1.0-0.8-2.01.3-1.31.5-2.3
Delay disc. indifference point, 0s delay4.44.86.5-1.9-2.02.1-1.92.01.92.2-2.62.6-2.42.5
Delay disc. indifference point, 16s delay0.00.00.10.30.20.20.3-0.00.00.10.1-0.10.3-0.3
Delay disc. indifference point, 2s delay0.40.50.8-0.5-0.60.7-0.50.60.60.8-0.90.9-0.80.7
Delay disc. indifference point, 24s delay0.70.71.40.80.9-0.71.0-1.1-1.2-0.60.8-0.80.60.2
Delay disc. indifference point, 4s delay0.20.20.70.1-0.10.30.10.30.40.3-0.80.8-0.20.4
Delay disc. indifference point, 8s delay0.00.00.10.10.1-0.10.3-0.1-0.1-0.1-0.20.2-0.00.3
Indifference point function ln k0.20.21.7-0.20.10.0-0.0-0.5-0.60.2-0.00.0-0.21.3
Indifference point function log k0.20.21.7-0.20.10.0-0.0-0.5-0.60.2-0.00.0-0.21.3
Patch foraging total patch changes 0 sec0.30.50.8-0.8-0.80.2-0.60.90.90.1-0.70.7-0.8-0.3
Patch foraging total patch changes 12 sec0.70.91.5-1.0-1.10.6-1.01.21.20.5-0.90.9-1.00.3
Patch foraging total patch changes 18 sec0.20.21.1-0.1-0.2-0.3-0.00.50.6-0.4-0.30.3-0.3-1.0
Patch foraging total patch changes 24 sec0.60.71.3-0.9-1.00.7-0.91.11.20.7-0.70.7-1.10.1
Patch foraging total patch changes 6 sec0.20.31.5-0.3-0.40.2-0.20.70.8-0.0-0.40.4-0.3-1.2
Patch foraging time to switch 0 sec0.10.10.6-0.2-0.20.7-0.30.20.20.80.2-0.2-0.0-0.2
Patch foraging water rate 0 sec0.10.20.80.20.3-0.90.4-0.5-0.6-0.80.2-0.20.20.1
Patch foraging water rate 12 sec0.91.32.4-1.5-1.41.2-1.51.10.91.2-0.10.1-1.21.2
Patch foraging water rate 18 sec0.50.63.7-0.7-0.70.7-0.90.2-0.00.8-0.10.1-0.71.9
Patch foraging water rate 24 sec1.21.72.7-1.6-1.61.2-1.61.21.01.2-0.90.9-1.31.4
Patch foraging water rate 6 sec0.91.33.4-1.2-1.21.1-1.40.80.71.2-0.70.7-1.41.9
Seeking ratio, delayed vs. immediate footshock0.00.00.10.40.1-0.20.0-0.1-0.0-0.2-0.10.10.2-0.3
Distance traveled before self-admin0.00.10.30.00.10.20.1-0.2-0.20.30.1-0.1-0.20.5
Distance traveled after self-admin1.31.41.9-0.9-0.91.3-1.01.01.01.3-1.41.4-1.41.3
Extensor digitorum longus weight4.216.618.34.34.1-4.34.3-3.9-3.7-4.34.0-4.04.0-3.8
Bone: elastic displacement0.91.11.90.91.0-1.20.9-1.3-1.4-1.20.9-0.91.0-0.3
Bone: elastic work0.91.21.51.11.1-1.21.1-1.1-1.1-1.20.9-0.91.1-1.0
Bone: endosteal estimation0.40.91.50.90.9-1.21.1-0.6-0.6-1.20.8-0.80.7-1.2
Bone: endosteal perimeter0.10.30.60.50.4-0.70.6-0.2-0.2-0.80.3-0.30.3-0.8
Epididymis fat weight12.529.135.7-6.0-6.05.3-5.55.95.85.0-5.55.5-5.32.9
Delta time in closed arm before/after self-admin0.10.10.4-0.2-0.30.1-0.20.50.60.0-0.10.1-0.5-0.7
Delta time in open arm before/after self-admin0.30.30.90.60.6-0.50.6-0.6-0.6-0.50.4-0.41.0-0.5
Diff in mean of infusions in LGA sessions0.30.30.90.50.5-0.90.7-0.4-0.4-0.90.2-0.20.5-0.7
Delay discount exponential model param0.00.10.2-0.3-0.20.0-0.40.10.10.00.3-0.3-0.1-0.1
Extinction: sum of active levers before priming0.30.30.50.50.5-0.60.6-0.5-0.5-0.60.7-0.70.6-0.5
Active lever presses in extinction session 60.90.91.90.70.8-1.01.1-1.1-1.4-1.00.8-0.80.9-0.4
Bone: final force0.20.30.80.50.3-0.80.6-0.00.0-0.90.4-0.40.2-0.8
Bone: final moment0.20.30.90.60.4-0.90.6-0.1-0.0-0.90.4-0.40.3-0.8
Food consumed during 24 hour testing period0.10.10.30.60.4-0.30.6-0.00.1-0.3-0.10.10.2-0.4
Glucose0.20.30.5-0.5-0.50.6-0.50.50.50.6-0.70.7-0.30.3
Heart weight8.912.615.6-3.6-3.53.6-4.03.43.53.7-3.33.3-3.73.3
Delay discount hyperbolic model param0.10.10.2-0.4-0.20.0-0.50.10.10.00.3-0.3-0.1-0.1
Intermittent access intake day 1-15 change0.30.30.50.70.6-0.30.5-0.7-0.7-0.20.6-0.60.20.6
Intermittent access intake escalation0.10.10.40.50.40.00.3-0.4-0.40.10.3-0.3-0.10.7
Intermittent access intake escalation 20.30.30.6-0.1-0.20.7-0.40.40.60.8-0.40.4-0.60.8
Intermitt. access day 1 inactive lever presses0.30.30.60.10.4-0.70.3-0.4-0.2-0.80.7-0.70.4-0.4
Intermitt. access day 15 inactive lever presses8.29.011.13.33.2-3.23.1-2.7-2.3-3.32.8-2.83.1-3.1
Intermitt. access escalation Index0.60.61.2-0.3-0.40.9-0.50.91.10.8-0.90.9-0.5-0.4
Intermittent access day 1 total infusions5.05.86.62.42.6-2.52.5-2.6-2.5-2.52.4-2.42.6-1.5
Intermittent access day 15 total infusions2.52.83.81.91.9-1.61.7-1.9-1.9-1.51.7-1.71.5-0.2
Intermittent access terminal intake (last 3 days)2.32.53.41.71.8-1.41.6-1.8-1.8-1.31.7-1.71.4-0.3
Intermittent access total infusions2.73.04.61.61.8-1.71.8-2.1-2.1-1.61.9-1.91.6-0.3
Intermittent access day 1 locomotion2.22.32.71.61.6-1.61.5-1.6-1.5-1.61.6-1.61.6-0.8
Intermittent access day 15 total locomotion0.80.91.31.01.0-0.81.1-1.0-0.9-0.81.2-1.20.9-0.5
Intermittent access total locomotion0.60.71.10.70.7-0.80.9-0.9-1.0-0.71.0-1.00.8-0.1
Intermittent access standard deviation0.40.50.70.70.6-0.90.6-0.7-0.7-0.80.8-0.80.5-0.2
Left kidney weight0.00.11.1-0.2-0.1-0.1-0.2-0.2-0.2-0.00.1-0.1-0.41.1
Right kidney weight1.23.35.3-1.9-1.81.6-1.91.61.51.7-1.71.7-2.02.3
Cocaine induced anxiety0.40.50.80.80.7-0.80.7-0.5-0.4-0.90.7-0.70.6-0.8
Post-drug Anxiety1.21.42.1-0.5-1.01.1-1.11.31.51.1-1.31.3-1.31.0
Baseline Anxiety2.32.43.2-1.1-1.41.8-1.41.41.51.8-1.81.8-1.41.4
Tail length0.00.10.5-0.3-0.3-0.0-0.2-0.0-0.20.0-0.00.0-0.30.7
Length with tail1.03.85.0-2.1-2.21.5-2.01.81.61.6-2.02.0-2.22.2
Length without tail0.71.52.4-1.2-1.30.8-1.21.31.20.8-1.51.5-1.41.2
Times rat made contact with spout1.61.93.81.41.4-1.91.6-1.2-1.0-2.01.0-1.01.1-1.2
Lifetime Intake3.84.36.22.02.1-2.12.1-2.4-2.5-2.02.2-2.22.0-0.6
Liver weight, left1.52.43.5-1.3-1.51.5-1.31.51.51.5-1.91.9-1.61.4
Liver weight, right8.814.716.2-3.7-3.94.0-3.93.93.94.0-3.83.8-4.03.2
Locomotor activity0.50.91.9-0.7-0.80.7-0.61.01.00.7-1.41.4-1.00.5
Locomotor testing distance0.10.10.90.20.1-0.10.20.10.1-0.2-0.20.20.2-0.9
Locomotor testing rearing1.01.53.31.01.0-1.01.3-1.1-1.3-1.01.2-1.21.4-1.8
Locomotion in novel chamber0.50.61.0-0.8-1.00.6-1.00.80.70.6-0.80.8-0.50.5
Locomotion in novel chamber post-restriction1.82.23.2-1.6-1.81.6-1.61.81.71.5-1.31.3-1.3-0.0
Fecal boli incidents, locomotor time 10.50.61.00.50.7-0.90.4-0.9-1.0-0.80.8-0.80.60.5
Change in fecal boli incidents, locomotor task4.64.46.1-2.1-2.21.8-2.02.12.01.8-2.52.5-2.21.6
Time >=10cm from walls, locomotor time 10.10.10.8-0.4-0.3-0.0-0.3-0.0-0.10.1-0.10.1-0.10.9
Bouts of movement, locomotor time 12.12.34.91.71.5-1.41.8-1.1-0.9-1.51.5-1.51.3-2.2
Total resting periods, locomotor time 12.42.65.51.81.6-1.51.9-1.2-1.0-1.61.4-1.41.4-2.3
Rest time, locomotor task time 10.10.10.20.30.3-0.30.4-0.4-0.4-0.40.2-0.20.2-0.4
Distance moved, locomotor task time 11.41.62.9-1.3-1.21.6-1.31.01.01.7-1.01.0-0.91.4
Vertical activity count, locomotor time 10.90.91.5-0.9-0.81.2-0.90.80.81.2-0.90.9-0.71.1
Time >=10cm from walls, locomotor time 20.40.40.90.50.6-0.80.7-0.8-1.0-0.70.6-0.60.40.3
Bouts of movement, locomotor time 20.20.20.6-0.3-0.40.4-0.20.60.70.4-0.00.0-0.7-0.2
Total resting periods, locomotor time 20.10.10.50.0-0.10.20.20.40.60.10.2-0.2-0.5-0.7
Rest time, locomotor task time 20.80.91.81.31.1-0.81.3-0.8-0.7-0.90.7-0.70.7-1.3
Distance moved, locomotor task time 20.70.82.0-1.0-0.91.0-0.90.60.41.1-0.80.8-0.51.4
Vertical activity count, locomotor time 20.30.31.4-0.7-0.50.3-0.40.1-0.00.4-0.50.5-0.31.2
Light reinforcement 12.85.28.62.92.5-2.22.5-1.9-1.6-2.31.8-1.82.4-2.7
Light reinforcement 22.33.06.42.52.2-1.51.8-1.7-1.4-1.51.4-1.41.9-1.4
Bone: marrow area0.40.91.50.90.9-1.21.1-0.7-0.6-1.20.8-0.80.8-1.2
Bone: maximum diameter0.71.32.91.31.1-1.41.3-0.6-0.4-1.50.9-0.90.9-1.7
Bone: maximum force0.10.10.30.20.1-0.50.30.10.1-0.60.1-0.10.1-0.6
Bone: maximum moment0.10.10.40.30.2-0.60.4-0.00.0-0.70.2-0.20.2-0.6
Mean time between licks in bursts2.73.75.1-1.9-2.01.9-1.92.02.01.9-1.91.9-2.31.5
Mean num. licks in bursts0.40.41.00.40.6-0.90.4-0.9-1.0-0.80.4-0.40.50.3
Cd content in liver0.10.10.30.1-0.10.10.10.30.40.1-0.30.3-0.1-0.6
Co content in liver4.55.26.62.42.6-2.42.5-2.6-2.5-2.32.1-2.12.2-1.2
Cu content in liver0.00.00.10.10.2-0.20.3-0.2-0.3-0.10.1-0.10.2-0.1
Fe content in liver0.00.00.1-0.10.0-0.1-0.1-0.1-0.3-0.00.3-0.30.2-0.3
K content in liver0.60.51.2-0.1-0.40.8-0.10.91.10.7-1.01.0-0.7-0.3
Mg content in liver0.70.71.5-0.4-0.60.5-0.31.11.20.4-1.21.2-0.8-0.2
Mn content in liver0.70.84.00.90.7-0.70.9-0.4-0.3-0.80.7-0.70.8-2.0
Na content in liver0.40.40.70.80.8-0.50.8-0.8-0.8-0.40.2-0.20.40.5
Rb content in liver0.10.10.4-0.1-0.20.20.00.40.50.1-0.30.3-0.1-0.6
Se content in liver0.30.40.7-0.5-0.60.6-0.40.80.80.5-0.50.5-0.6-0.6
Sr content in liver0.60.51.4-0.3-0.40.7-0.40.40.50.7-1.01.0-0.61.2
Zn content in liver1.41.52.2-1.2-1.31.1-1.01.51.51.1-1.41.4-1.30.5
Bone: minimum diameter0.20.30.7-0.4-0.5-0.2-0.20.80.9-0.4-0.60.6-0.6-0.5
Time in familiar zone, hab. session 10.80.71.2-0.8-0.80.6-0.71.00.90.6-1.11.1-0.90.5
Time in novel zone, hab. session 10.30.30.8-0.9-0.70.7-0.80.40.30.70.0-0.0-0.20.1
Total zone transitions, hab. session 10.10.10.20.40.3-0.30.5-0.2-0.2-0.30.3-0.30.2-0.1
Total locomotion distance, hab. session 10.20.30.50.50.6-0.40.7-0.6-0.7-0.40.4-0.40.50.3
Locomotion velocity, hab. session 10.81.11.81.31.3-1.01.3-1.2-1.2-0.90.9-0.91.0-0.2
Time in familiar zone, hab. session 20.00.00.20.10.0-0.20.10.20.3-0.2-0.10.1-0.2-0.4
Time in novel zone, hab. session 20.40.40.7-0.8-0.70.8-0.80.40.30.8-0.40.4-0.40.7
Total zone transitions, hab. session 20.10.10.90.30.1-0.30.50.20.3-0.30.0-0.00.0-0.9
Total locomotion distance, hab. session 20.20.31.10.50.4-0.60.70.00.1-0.70.3-0.30.2-1.1
Locomotion velocity, hab. session 20.40.51.60.70.6-0.80.9-0.2-0.1-0.90.5-0.50.4-1.3
Novel to familiar place preference ratio1.31.32.2-1.1-1.11.4-1.21.01.01.5-1.01.0-1.11.0
Novelty place preference1.81.82.8-1.4-1.41.6-1.41.31.21.7-1.21.2-1.31.1
Time in novel zone, NPP test2.02.03.1-1.5-1.41.7-1.61.31.21.8-1.31.3-1.41.2
Total zone transitions, NPP test1.21.82.21.41.4-1.11.5-1.2-1.1-1.11.5-1.51.3-1.4
Total locomotion distance, NPP test1.82.53.11.71.6-1.41.7-1.5-1.4-1.41.7-1.71.8-1.5
Locomotion velocity, NPP test2.84.04.92.22.1-1.92.2-1.9-1.8-1.92.0-2.02.1-1.9
Intraocular pressure5.88.19.8-3.1-3.02.7-2.93.13.02.6-2.82.8-3.11.9
Delta distance traveled before/after self-admin1.51.62.2-1.0-1.21.3-1.31.41.41.3-1.51.5-1.30.6
Delta ambulatory time before/after self-admin0.40.40.8-0.3-0.50.6-0.50.70.70.6-0.90.9-0.70.2
Parametrial fat weight6.412.417.9-3.1-3.63.4-3.54.14.23.2-3.83.8-3.71.8
Pavlov. Cond. lever latency1.51.93.1-1.5-1.41.7-1.41.11.01.8-1.21.2-1.31.4
Pavlov. Cond. magazine entry latency0.00.00.20.20.1-0.20.10.10.1-0.30.1-0.10.1-0.5
Pavlov. Cond. change in total contacts0.00.00.10.10.1-0.30.1-0.1-0.0-0.30.1-0.10.1-0.1
Pavlov. Cond. index score0.60.71.31.00.8-1.10.9-0.5-0.4-1.20.7-0.70.6-1.1
Pavlov. Cond. latency score0.60.71.51.00.8-1.10.8-0.4-0.3-1.20.7-0.70.6-1.2
Pavlov. Cond. lever contacts0.81.01.71.11.0-1.31.0-0.8-0.7-1.30.9-0.90.9-0.9
Pavlov. Cond. magazine entry number0.40.50.9-0.8-0.70.8-0.70.40.30.9-0.60.6-0.61.0
Pavlov. Cond. intertrial magazine entries1.11.32.21.01.3-1.21.2-1.4-1.5-1.11.1-1.11.2-0.1
Pavlov. Cond. lever-magazine prob. diff.1.31.62.41.41.3-1.51.3-1.0-0.9-1.51.2-1.21.1-1.3
Pavlov. Cond. response bias1.31.62.11.31.3-1.51.2-1.2-1.1-1.41.2-1.21.3-0.9
Pavlov. Cond. lever latency1.41.92.8-1.6-1.51.1-1.71.41.41.1-1.31.3-1.60.9
Pavlov. Cond. magazine entry latency0.30.30.70.70.6-0.20.7-0.4-0.3-0.20.7-0.70.4-0.8
Pavlov. Cond. change in total contacts0.50.70.90.90.9-0.81.0-0.7-0.6-0.80.9-0.90.8-1.0
Pavlov. Cond. index score1.01.31.81.31.2-0.91.3-1.1-1.0-0.91.3-1.31.1-1.0
Pavlov. Cond. latency score1.11.31.91.31.2-0.91.3-1.1-1.0-0.91.4-1.41.1-1.0
Pavlov. Cond. lever contacts0.60.91.41.11.0-0.81.2-0.9-0.8-0.81.0-1.00.9-0.7
Pavlov. Cond. magazine entry number0.10.10.3-0.5-0.40.1-0.50.20.10.2-0.40.4-0.10.5
Pavlov. Cond. intertrial magazine entries3.14.05.0-2.2-2.22.1-2.12.12.02.0-2.02.0-2.01.3
Pavlov. Cond. lever-magazine prob. diff.0.70.91.31.11.0-0.71.2-0.8-0.7-0.81.1-1.10.9-1.0
Pavlov. Cond. response bias1.21.72.51.61.5-1.01.6-1.2-1.1-1.01.3-1.31.3-1.0
Time in closed arm before self-admin0.20.20.6-0.5-0.70.2-0.40.60.40.2-0.40.4-0.80.4
Time in closed arm after self-admin0.70.81.5-1.1-1.20.6-0.91.00.80.6-0.60.6-1.20.5
Time in open arm before self-admin0.10.10.2-0.3-0.10.4-0.40.20.40.4-0.00.0-0.20.1
Time in open arm after self-admin1.11.21.91.41.4-0.91.0-1.0-0.8-0.91.0-1.01.3-1.0
Bone: periosteal estimation0.51.12.31.11.0-1.41.2-0.6-0.5-1.50.8-0.80.7-1.3
Bone: periosteal perimeter0.20.30.70.60.4-0.70.6-0.10.1-0.80.2-0.20.2-0.8
Bone: post-yield work0.70.91.60.80.9-1.30.9-1.1-1.2-1.20.8-0.80.7-0.1
Progressive ratio test 1 active lever presses2.42.53.51.51.5-1.71.6-1.8-1.9-1.61.6-1.61.6-0.5
Progressive ratio test 1 breakpoint2.12.22.91.41.4-1.61.5-1.6-1.7-1.61.5-1.51.5-0.6
Progressive ratio test 1 inactive lever presses5.76.27.42.32.4-2.72.4-2.7-2.7-2.62.7-2.72.6-1.4
Progressive ratio test 2 active lever presses0.30.31.00.40.5-0.20.5-0.8-1.0-0.10.5-0.50.40.9
Progressive ratio test 2 breakpoint0.40.41.20.50.6-0.30.6-0.9-1.1-0.20.6-0.60.50.8
Progressive ratio test 2 inactive lever presses2.73.14.02.01.9-1.71.8-1.9-1.9-1.71.9-1.91.8-0.8
Incentive Sensitization - Responses0.30.32.2-0.3-0.00.6-0.2-0.2-0.20.8-0.30.3-0.31.5
Incentive Sensitization - Breakpoint0.50.52.5-0.5-0.20.9-0.40.10.01.0-0.50.5-0.51.6
Sum of active levers in priming session hrs 5-60.40.41.51.00.7-0.50.6-0.20.0-0.50.2-0.20.5-1.2
Progressive ratio0.20.30.50.20.3-0.70.5-0.4-0.5-0.70.5-0.50.5-0.7
Food seeking constrained by brief footshock6.37.711.82.22.6-3.02.4-3.2-3.4-2.83.0-3.02.9-1.2
Seeking ratio, punishment vs. effort0.40.50.80.60.8-0.60.5-0.9-0.9-0.50.9-0.90.70.2
Retroperitoneal fat weight20.065.685.0-8.4-8.88.3-8.29.29.27.9-8.08.0-8.03.7
Reaction time number correct0.40.61.00.80.8-1.00.8-0.7-0.6-1.00.7-0.70.7-0.8
Reaction time mean minus median0.00.00.10.00.0-0.30.0-0.2-0.3-0.30.1-0.10.20.2
Reaction time mean minus median AUC0.00.00.1-0.1-0.20.0-0.30.10.10.0-0.20.2-0.00.4
Reaction time num false alarms0.30.31.8-0.1-0.20.3-0.10.81.00.2-0.40.4-0.1-1.3
Reaction time num false alarms AUC0.30.41.60.0-0.10.20.00.81.00.1-0.50.5-0.2-1.3
Reaction time trials correct on left0.40.61.00.80.8-1.00.8-0.7-0.6-1.00.7-0.70.7-0.8
Reaction time trials on left0.50.71.10.80.9-1.00.9-0.7-0.6-1.00.7-0.70.8-0.8
Reaction time mean1.01.44.2-1.4-1.21.0-1.40.80.81.1-0.80.8-1.32.1
Reaction time mean AUC0.91.34.0-1.3-1.10.9-1.30.70.71.0-0.80.8-1.12.0
Median of all reaction times1.31.85.3-1.4-1.21.2-1.50.90.91.3-0.90.9-1.52.3
Reaction time omissions0.10.10.20.30.2-0.30.4-0.00.0-0.4-0.40.40.2-0.3
Reaction time false alarm rate0.50.61.6-0.5-0.60.7-0.51.11.30.6-0.90.9-0.5-0.8
Reaction time premature initiation rate0.20.30.6-0.4-0.50.8-0.50.50.50.8-0.30.3-0.80.4
Reaction time premature initiations0.00.00.10.0-0.00.20.00.10.10.20.2-0.2-0.3-0.1
Std. dev. reaction times0.20.30.6-0.7-0.60.3-0.60.40.40.3-0.30.3-0.50.8
Reaction time trials completed0.50.71.10.80.9-1.00.9-0.7-0.6-1.00.7-0.70.8-0.8
Reaction time trials AUC0.60.91.20.91.0-1.11.0-0.8-0.7-1.10.9-0.90.9-1.0
Run reversals in cocaine runway, females0.20.21.2-0.7-0.30.3-0.5-0.0-0.10.40.0-0.0-0.41.1
Run reversals in cocaine runway, males0.20.20.50.30.4-0.50.2-0.7-0.7-0.40.5-0.50.60.4
Latency to leave start box in cocaine runway0.50.61.41.20.9-0.60.8-0.9-0.9-0.60.5-0.50.9-0.1
Latency to leave start box in cocaine runway, F0.40.41.01.00.8-0.40.7-0.7-0.6-0.40.4-0.40.8-0.4
Latency to leave start box in cocaine runway, M1.21.21.91.31.0-1.20.9-1.3-1.4-1.11.0-1.01.2-0.2
Std. dev. time between licks in bursts0.30.40.9-0.1-0.40.6-0.10.81.00.5-0.80.8-0.8-0.1
Total sessions with >9 infusions3.94.37.01.91.9-2.32.0-2.4-2.7-2.12.1-2.12.1-0.8
Short access day 1 total inactive lever presses4.24.76.22.42.5-2.02.2-2.4-2.2-2.02.3-2.32.2-1.2
Short access day 10 total inactive lever presses1.01.13.10.91.0-0.90.9-0.7-0.4-0.91.1-1.11.2-1.8
Short access day 1 total infusions6.36.88.22.52.5-2.92.6-2.7-2.8-2.82.6-2.62.7-1.9
Short access day 10 total infusions4.44.97.02.22.3-2.32.3-2.6-2.6-2.22.2-2.22.1-0.6
Short access total infusions4.04.56.32.02.1-2.32.1-2.4-2.5-2.22.1-2.12.1-0.8
Short access day 1 locomotion8.99.511.13.02.9-3.23.0-3.1-3.2-3.23.3-3.33.1-2.5
Short access day 10 total locomotion1.01.11.71.31.1-1.01.0-1.1-1.1-0.91.3-1.31.0-0.4
Short access total locomotion1.11.21.91.11.0-1.11.0-1.3-1.4-1.01.3-1.31.0-0.0
One hour access (0.3 mA shock)1.82.12.61.61.6-1.61.6-1.6-1.6-1.51.5-1.51.3-0.5
Compulsive drug intake1.11.12.1-0.7-1.00.7-1.11.31.40.6-1.41.4-1.0-0.1
One hour access (shock baseline)2.63.05.21.61.7-1.61.9-2.1-2.3-1.41.9-1.91.6-0.2
Social response proportion0.40.41.5-0.4-0.40.1-0.20.20.10.1-1.11.1-0.41.2
Social responses0.10.10.4-0.1-0.2-0.10.10.40.4-0.1-0.60.6-0.4-0.0
Social time0.10.20.7-0.4-0.40.0-0.20.20.10.1-0.50.5-0.40.9
Soleus weight3.710.815.13.43.4-3.93.4-3.2-3.1-3.93.0-3.03.1-2.5
Bone: stiffness0.00.10.2-0.0-0.20.00.00.40.4-0.0-0.10.1-0.1-0.4
Tibialis anterior weight3.210.815.13.53.3-3.13.4-2.8-2.6-3.13.4-3.43.4-3.9
Time to tail flick, vehicle, before self-admin1.61.72.8-1.7-1.51.3-1.51.31.11.3-1.01.0-1.21.1
Time to tail flick, vehicle, after self-admin3.33.55.0-2.2-2.21.7-1.82.12.01.6-2.02.0-1.81.0
Time to tail flick, test, before self-admin0.70.71.00.80.8-0.80.8-1.0-1.0-0.70.9-0.90.8-0.2
Time to tail flick, test, after self-admin0.10.11.2-0.1-0.2-0.2-0.2-0.1-0.2-0.1-0.20.2-0.21.1
Delta time to tail flick, vehicle, before/after SA0.20.10.4-0.0-0.20.00.10.40.5-0.1-0.60.6-0.1-0.7
Delta time to tail flick, test, before/after SA0.40.30.50.70.6-0.70.5-0.7-0.7-0.70.4-0.40.50.3
Tibia length2.26.37.2-2.5-2.52.5-2.52.42.32.5-2.72.7-2.52.5
Ambulatory time before self-admin0.10.10.20.10.30.20.3-0.3-0.30.30.4-0.40.00.2
Ambulatory time after self-admin0.80.91.4-0.7-0.71.1-0.90.70.81.2-0.90.9-1.11.1
Bone: tissue strength1.01.01.5-1.0-1.00.8-1.00.90.80.8-1.11.1-0.91.2
Total heroin consumption2.42.83.31.71.7-1.81.8-1.6-1.5-1.81.6-1.61.6-1.4
Bone: trabecular number3.45.37.92.52.5-2.82.6-2.3-2.2-2.81.8-1.82.2-1.3
Bone: trabecular spacing3.44.47.6-2.2-2.12.7-2.31.81.62.8-1.71.7-1.82.0
Bone: trabecular thickness0.91.11.81.11.0-1.31.3-0.9-0.8-1.30.8-0.81.0-0.8
Bone: trabecular tissue density0.40.51.40.60.6-0.50.6-0.6-0.6-0.41.2-1.20.8-0.4
Water consumed over 24 hours0.91.02.21.41.2-1.31.5-0.7-0.4-1.40.3-0.30.7-1.0
Number of responses in last shaping day1.01.11.81.10.9-1.21.1-1.2-1.3-1.20.9-0.90.90.0