Hub : Genes

Abhd1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose isoform ratio NM_001008520.1 0.04 0.04 8.7e-04 0.02 0.02 0.02 0.02 1.4e-03 1.7e-03 2.8e-03 1.9e-03
2 NAcc gene expression Abhd1 0.08 0.05 8.3e-10 0.04 0.06 0.05 0.05 8.4e-07 2.4e-09 3.1e-08 2.8e-08
3 Adipose isoform ratio XM_063261874.1 0.04 0.04 1.1e-03 0.02 0.02 0.02 0.02 1.4e-03 1.6e-03 2.6e-03 1.7e-03
4 BLA gene expression Abhd1 0.15 0.15 9.0e-04 0.04 0.03 0.03 0.04 3.3e-03 1.7e-02 1.4e-02 4.6e-03
5 Eye isoform ratio NM_001008520.1 0.38 0.28 7.4e-03 0.1 0.06 0.03 0.06 1.3e-02 5.2e-02 1.1e-01 4.8e-02
6 Brain isoform ratio XM_063261874.1 0.03 0.03 9.3e-04 0.02 0.03 0.02 0.02 3.4e-03 8.3e-04 4.4e-03 6.2e-03
7 PL isoform ratio XM_063261874.1 0.03 0.02 2.1e-03 0.02 0.02 0.02 0.02 2.0e-03 2.1e-03 1.5e-03 2.0e-03
8 Adipose mRNA stability Abhd1 0.05 0.05 4.2e-05 0.03 0.04 0.04 0.04 9.6e-05 6.1e-05 6.2e-05 7.0e-05
9 PL alternative TSS XM_063261874.1 0.04 0.03 8.0e-05 0.04 0.04 0.04 0.04 7.7e-05 3.6e-05 1.8e-05 1.9e-05
10 PL alternative TSS XM_063261874.1 0.04 0.03 2.5e-05 0.04 0.04 0.05 0.05 1.4e-05 1.5e-05 6.8e-06 5.5e-06
11 PL alternative TSS XM_039112176.2 0.04 0.03 1.4e-05 0.05 0.05 0.05 0.05 7.3e-06 7.7e-06 5.3e-06 3.6e-06
12 pVTA gene expression Abhd1 0.03 0.03 4.3e-04 0.04 0.04 0.03 0.04 5.8e-04 2.8e-04 1.4e-03 7.6e-04
13 PL gene expression Abhd1 0.13 0.15 8.2e-08 0.08 0.07 0.08 0.08 7.1e-09 2.8e-08 8.2e-09 1.0e-08
14 Adipose gene expression Abhd1 0.03 0.03 2.3e-03 0.02 0.02 0 0.02 3.3e-03 3.9e-03 7.5e-02 4.7e-03
15 Liver isoform ratio NM_001008520.1 0.07 0.06 1.4e-06 0.04 0.04 0.04 0.04 1.6e-05 1.2e-05 1.1e-05 1.2e-05
16 PL intron excision ratio chr6_31143938_31144081 0.05 0.07 7.1e-03 0.02 0.01 0 0.01 6.4e-03 8.8e-03 1.8e-01 7.5e-03
17 Liver mRNA stability Abhd1 0.04 0.04 8.1e-04 0.02 0.02 0.02 0.02 1.4e-03 2.4e-03 1.5e-03 2.1e-03
18 Brain alternative TSS XM_063261874.1 0.05 0.03 2.6e-05 0.05 0.04 0.04 0.04 3.3e-05 8.8e-05 1.8e-04 2.3e-04
19 Brain alternative TSS XM_039112176.2 0.04 0.03 6.2e-05 0.04 0.04 0.03 0.03 1.0e-04 1.9e-04 4.3e-04 3.4e-04
20 Brain alternative TSS XM_063261874.1 0.04 0.03 4.0e-05 0.04 0.04 0.04 0.04 6.8e-05 1.4e-04 2.8e-04 2.5e-04
21 Brain alternative TSS NM_001008520.1 0.02 0.02 6.3e-03 0.01 0.01 0.01 0.01 1.6e-02 2.3e-02 8.3e-02 2.4e-02
22 Brain gene expression Abhd1 0.04 0.03 6.7e-05 0.03 0.03 0.03 0.03 5.5e-04 5.7e-04 1.5e-03 1.1e-03
23 pVTA mRNA stability Abhd1 0.06 0.05 4.4e-03 0.03 0.03 0.03 0.03 1.4e-03 2.2e-03 1.7e-03 4.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23
Bone: apparent density3.86.69.11.7-2.4-2.0-1.92.0-2.7-3.02.7-3.0-3.03.0-2.8-2.7-3.02.72.82.7-2.72.7-2.72.0-2.01.9
Area under the delay curve0.00.00.30.1-0.2-0.0-0.3-0.1-0.2-0.20.2-0.2-0.20.2-0.2-0.6-0.20.30.10.4-0.10.1-0.1-0.00.0-0.2
BMI with tail0.62.17.5-2.51.92.62.7-2.01.41.1-1.30.90.8-0.81.10.80.9-1.1-1.2-0.91.2-1.21.2-0.80.8-1.0
BMI without tail0.92.86.4-2.22.02.52.5-2.11.71.5-1.61.41.4-1.41.41.11.3-1.4-1.6-1.21.6-1.61.6-1.21.2-1.4
Body weight2.410.413.6-3.43.53.23.5-3.73.43.2-3.33.13.1-3.13.22.83.0-3.1-3.3-2.83.3-3.33.3-3.23.2-3.3
Weight adjusted by age0.10.20.5-0.3-0.10.5-0.10.7-0.3-0.20.3-0.2-0.10.1-0.3-0.5-0.20.40.40.4-0.50.5-0.50.7-0.70.5
Bone surface1.83.35.80.6-1.3-0.7-0.80.9-1.9-2.31.9-2.4-2.42.4-2.1-2.2-2.42.22.12.2-2.02.0-2.00.8-0.80.9
Bone volume1.93.55.81.1-1.6-1.3-1.11.0-2.0-2.32.0-2.4-2.42.4-2.1-2.1-2.32.12.12.1-2.02.0-2.00.9-0.90.9
Breakpoint value in progressive ratio session0.80.91.60.8-1.0-0.9-0.30.6-0.9-0.71.0-0.7-0.70.7-0.9-1.1-0.91.21.21.1-1.31.3-1.30.9-0.90.8
Number of licking bursts0.20.31.9-1.00.71.41.2-1.00.2-0.1-0.2-0.3-0.30.3-0.0-0.2-0.20.10.00.20.2-0.20.2-0.40.4-0.4
Context. condit. distance diff. score0.00.10.40.4-0.3-0.6-0.40.5-0.1-0.10.1-0.0-0.00.0-0.0-0.10.00.00.00.10.1-0.10.10.1-0.10.2
Locomotion velocity, session 10.20.20.8-0.80.50.80.3-0.80.20.0-0.2-0.1-0.00.00.10.2-0.0-0.3-0.3-0.20.4-0.40.4-0.80.8-0.9
Locomotion distance, session 11.11.42.80.3-0.9-0.6-1.10.5-1.3-1.61.3-1.7-1.71.7-1.4-1.2-1.71.31.31.2-1.21.2-1.20.5-0.50.3
Locomotion velocity, session 20.30.30.5-0.40.50.10.5-0.50.60.5-0.60.50.5-0.50.60.60.5-0.7-0.7-0.60.7-0.70.7-0.30.3-0.5
Locomotion distance, session 20.00.00.4-0.70.20.30.1-0.40.1-0.2-0.1-0.1-0.10.1-0.00.2-0.1-0.1-0.0-0.20.0-0.00.0-0.10.1-0.3
Locomotion velocity, session 30.70.91.60.2-0.8-0.2-0.61.3-0.9-0.90.9-0.9-0.80.8-0.9-0.8-0.80.91.00.8-1.11.1-1.11.2-1.21.2
Locomotion distance, session 30.50.61.0-0.5-0.40.2-0.20.4-0.7-1.00.8-1.0-1.01.0-0.9-0.7-1.00.80.90.7-0.80.8-0.80.5-0.50.5
Stereotopy head waving bouts, day 32.32.73.61.6-1.7-1.5-1.11.8-1.7-1.51.7-1.5-1.41.4-1.6-1.7-1.51.71.61.7-1.71.7-1.71.9-1.91.9
Stereotopy head waving duration, day 30.30.40.80.9-0.7-0.8-0.30.7-0.5-0.30.6-0.3-0.30.3-0.5-0.5-0.30.50.50.5-0.70.7-0.70.7-0.70.8
Locomotion velocity, session 70.80.91.5-0.1-0.60.10.20.2-0.9-1.21.0-1.2-1.21.2-1.2-1.2-1.21.21.21.2-1.11.1-1.10.5-0.50.4
Locomotion distance, session 70.20.31.4-1.20.51.11.1-0.90.0-0.20.0-0.4-0.40.4-0.2-0.3-0.40.40.40.3-0.20.2-0.2-0.40.4-0.6
Stereotopy head waving bouts, day 70.00.00.2-0.30.10.10.30.5-0.1-0.10.1-0.1-0.10.1-0.1-0.1-0.1-0.0-0.00.1-0.00.0-0.00.3-0.30.5
Stereotopy head waving duration, day 70.50.61.90.6-0.8-0.7-0.71.4-0.7-0.60.7-0.5-0.50.5-0.6-0.7-0.50.60.50.7-0.60.6-0.61.1-1.11.3
Locomotion velocity, session 80.30.40.70.6-0.7-0.9-0.60.8-0.6-0.60.6-0.5-0.50.5-0.6-0.6-0.50.60.60.6-0.50.5-0.50.5-0.50.6
Locomotion distance, session 80.20.40.60.4-0.6-0.7-0.70.5-0.6-0.80.6-0.7-0.70.7-0.6-0.6-0.70.60.60.6-0.50.5-0.50.4-0.40.4
Degree of sensitization distance1.01.02.0-0.91.10.91.4-1.41.01.0-1.00.90.9-0.90.90.70.9-0.8-0.8-0.71.0-1.01.0-1.21.2-1.2
Degree of sensitization stereotypy0.20.30.5-0.70.60.50.60.00.50.5-0.50.50.5-0.50.50.50.5-0.6-0.7-0.50.6-0.60.6-0.10.10.1
Conditioned locomotion3.44.05.12.3-2.2-2.0-2.22.2-2.0-1.92.0-1.9-1.91.9-1.9-1.8-1.81.91.91.8-1.91.9-1.92.0-2.02.3
Cocaine response after cond. corrected0.40.50.90.4-0.5-0.4-0.40.0-0.7-0.80.7-0.8-0.90.9-0.8-0.9-0.80.90.90.9-0.90.9-0.90.0-0.00.1
Cocaine response after cond. not corrected1.11.31.90.9-1.1-0.9-1.00.7-1.2-1.31.2-1.4-1.41.4-1.3-1.3-1.31.31.21.3-1.21.2-1.20.7-0.70.8
Cocaine response before conditioning2.02.44.71.8-1.7-1.8-2.02.2-1.5-1.51.5-1.4-1.41.4-1.4-1.2-1.41.11.11.2-0.80.8-0.82.1-2.12.1
Saline control response0.91.22.51.0-1.1-1.3-1.01.6-1.0-1.01.0-1.0-1.01.0-1.0-0.9-0.90.90.90.9-1.01.0-1.01.4-1.41.5
Bone: connectivity density3.55.57.71.2-2.0-1.5-1.41.8-2.5-2.72.5-2.8-2.82.8-2.6-2.6-2.72.62.72.6-2.62.6-2.61.8-1.81.8
Bone: cortical apparent density0.30.40.70.4-0.5-0.2-0.30.2-0.6-0.70.7-0.8-0.80.8-0.7-0.7-0.80.70.70.7-0.70.7-0.70.5-0.50.4
Bone: cortical area0.40.61.4-0.4-0.20.20.1-0.1-0.7-1.10.7-1.2-1.21.2-0.9-1.0-1.10.90.91.0-0.70.7-0.7-0.20.2-0.1
Bone: cortical porosity1.71.83.61.5-1.5-1.7-1.91.8-1.3-1.21.3-1.1-1.11.1-1.2-1.0-1.11.01.11.0-1.11.1-1.11.7-1.71.7
Bone: cortical porosity1.61.72.91.4-1.5-1.7-1.71.5-1.4-1.31.3-1.2-1.21.2-1.3-1.1-1.21.11.21.1-1.21.2-1.21.4-1.41.4
Bone: cortical thickness0.10.20.5-0.60.50.60.6-0.50.2-0.1-0.2-0.2-0.20.20.10.2-0.1-0.2-0.2-0.20.4-0.40.4-0.70.7-0.6
Bone: cortical thickness1.11.21.90.7-0.9-0.4-0.60.6-1.2-1.31.2-1.4-1.41.4-1.3-1.2-1.41.31.41.2-1.21.2-1.20.5-0.50.6
Bone: cortical tissue density0.20.20.50.3-0.3-0.1-0.20.0-0.5-0.60.5-0.7-0.70.7-0.6-0.5-0.70.60.60.5-0.50.5-0.50.3-0.30.3
Condit. Reinf. active minus inactive responses1.11.22.2-1.31.31.41.5-1.41.11.0-1.00.80.8-0.80.90.90.9-0.9-0.8-0.91.0-1.01.0-1.31.3-1.4
Condit. Reinf. active-inactive response ratio1.11.22.0-1.11.11.31.4-1.41.01.0-1.00.90.9-0.90.90.91.0-0.9-0.8-0.90.9-0.90.9-1.41.4-1.4
Condit. Reinf. active responses0.10.10.2-0.20.00.30.1-0.3-0.2-0.30.2-0.4-0.40.4-0.3-0.3-0.40.20.20.3-0.00.0-0.0-0.10.1-0.2
Condit. Reinf. inactive responses1.41.72.20.9-1.2-1.1-1.31.0-1.3-1.51.3-1.5-1.51.5-1.4-1.4-1.51.21.21.4-1.11.1-1.11.3-1.31.4
Incentive salience index mean0.10.10.5-0.50.30.40.6-0.70.1-0.0-0.1-0.1-0.10.1-0.00.0-0.10.10.1-0.00.1-0.10.1-0.60.6-0.7
Condit. Reinf. lever presses0.50.71.10.8-0.9-1.1-0.70.3-0.9-1.00.9-1.0-1.01.0-0.9-0.8-0.90.90.90.8-0.80.8-0.80.4-0.40.3
Condit. Reinf. active minus inactive responses3.74.88.71.4-2.0-1.0-2.22.9-2.2-2.22.2-2.1-2.12.1-2.2-2.0-2.12.02.02.0-1.91.9-1.93.0-3.02.9
Condit. Reinf. active-inactive response ratio1.31.54.80.8-1.1-0.7-1.42.1-1.1-1.11.1-1.0-1.01.0-1.0-0.9-1.00.80.80.9-0.80.8-0.82.0-2.02.2
Condit. Reinf. active responses2.94.06.31.1-1.8-0.8-1.92.3-2.0-2.12.0-2.0-2.02.0-2.1-2.0-2.02.02.02.0-2.02.0-2.02.5-2.52.3
Condit. Reinf. inactive responses1.21.52.50.5-1.1-0.4-0.70.5-1.3-1.41.3-1.4-1.41.4-1.4-1.5-1.41.61.61.5-1.51.5-1.50.8-0.80.5
Condit. Reinf. lever presses2.02.84.31.5-1.7-1.1-1.92.0-1.7-1.71.7-1.6-1.61.6-1.6-1.6-1.61.71.61.6-1.41.4-1.42.1-2.11.9
Condit. Reinf. lever reinforcers received2.73.76.11.1-1.7-0.8-1.82.3-1.9-2.01.9-1.9-1.91.9-2.0-1.9-1.91.91.91.9-1.81.8-1.82.5-2.52.3
Conditioned reinforcement - actives2.34.010.63.3-2.5-3.0-2.82.5-1.9-1.41.8-1.2-1.21.2-1.5-1.8-1.21.81.81.7-1.91.9-1.91.9-1.92.0
Conditioned reinforcement - inactives3.04.48.73.0-2.4-2.7-1.81.8-2.2-2.02.2-2.0-2.02.0-2.1-1.9-1.92.01.92.1-2.02.0-2.02.0-2.02.0
Conditioned locomotion0.81.03.11.8-1.4-1.6-1.51.5-0.8-0.30.8-0.2-0.20.2-0.5-1.0-0.20.80.80.7-1.01.0-1.01.1-1.11.3
Patch foraging indifference point 0 sec0.50.82.4-1.51.11.31.1-0.91.00.8-0.90.70.7-0.70.91.00.8-0.9-0.7-1.10.7-0.70.7-0.80.8-0.8
Patch foraging indifference point AUC0.81.22.70.1-0.60.3-0.00.1-1.1-1.41.2-1.6-1.61.6-1.4-1.3-1.61.21.11.2-1.11.1-1.10.4-0.40.5
Delay disc. indifference point, 0s delay3.13.45.0-1.11.61.11.3-2.11.91.9-1.91.81.8-1.81.91.71.9-1.8-2.0-1.72.0-2.02.0-2.22.2-2.2
Delay disc. indifference point, 16s delay0.00.10.4-0.1-0.10.2-0.60.3-0.2-0.20.2-0.1-0.10.1-0.2-0.4-0.20.1-0.00.2-0.10.1-0.10.3-0.30.1
Delay disc. indifference point, 2s delay0.20.20.5-0.40.40.30.2-0.50.40.4-0.40.40.4-0.40.40.20.4-0.3-0.5-0.20.6-0.60.6-0.70.7-0.7
Delay disc. indifference point, 24s delay0.91.03.11.5-1.2-1.5-1.81.0-1.0-0.81.0-0.7-0.70.7-0.9-1.1-0.81.00.70.9-0.80.8-0.80.6-0.60.4
Delay disc. indifference point, 4s delay0.00.00.2-0.20.20.30.2-0.50.0-0.1-0.0-0.1-0.10.1-0.1-0.3-0.10.1-0.10.20.1-0.10.1-0.20.2-0.2
Delay disc. indifference point, 8s delay0.00.00.20.3-0.2-0.2-0.30.1-0.1-0.00.10.00.0-0.0-0.1-0.4-0.00.30.10.2-0.10.1-0.1-0.00.0-0.2
Indifference point function ln k0.20.42.31.2-0.8-1.5-1.11.0-0.4-0.20.3-0.0-0.00.0-0.1-0.20.00.30.30.3-0.30.3-0.30.7-0.70.5
Indifference point function log k0.20.42.31.2-0.8-1.5-1.11.0-0.4-0.20.3-0.0-0.00.0-0.1-0.20.00.30.30.3-0.30.3-0.30.7-0.70.5
Patch foraging total patch changes 0 sec0.40.82.5-1.61.21.41.2-1.01.00.8-0.90.70.7-0.70.81.00.8-0.8-0.7-1.00.7-0.70.7-0.70.7-0.7
Patch foraging total patch changes 12 sec1.31.72.7-1.51.41.51.6-1.61.31.2-1.21.11.1-1.11.11.31.1-1.3-1.2-1.41.2-1.21.2-1.31.3-1.2
Patch foraging total patch changes 18 sec0.30.52.3-1.50.91.51.3-0.90.50.2-0.50.10.1-0.10.30.40.1-0.3-0.2-0.40.2-0.20.2-0.60.6-0.6
Patch foraging total patch changes 24 sec0.81.32.4-1.51.31.51.2-1.21.21.1-1.11.11.1-1.11.11.21.0-1.2-1.0-1.31.1-1.11.1-0.90.9-0.7
Patch foraging total patch changes 6 sec0.50.84.4-1.91.22.11.4-1.10.70.5-0.60.40.4-0.40.40.60.3-0.6-0.5-0.80.5-0.50.5-0.80.8-0.9
Patch foraging time to switch 0 sec0.10.10.7-0.60.40.60.8-0.30.30.4-0.30.40.4-0.40.2-0.10.3-0.1-0.20.00.2-0.20.2-0.10.10.0
Patch foraging water rate 0 sec0.10.21.20.8-0.6-1.0-1.10.9-0.3-0.40.3-0.3-0.20.2-0.2-0.1-0.20.20.20.0-0.20.2-0.20.4-0.40.6
Patch foraging water rate 12 sec0.71.42.4-0.00.70.10.1-0.41.21.3-1.21.51.5-1.51.41.51.4-1.4-1.3-1.51.3-1.31.3-0.90.9-0.8
Patch foraging water rate 18 sec0.40.61.10.9-0.1-1.1-1.00.50.50.8-0.61.01.0-1.00.80.91.0-0.9-1.0-0.70.9-0.90.9-0.10.1-0.2
Patch foraging water rate 24 sec1.52.13.8-0.41.00.21.0-0.81.51.8-1.51.91.9-1.91.71.61.8-1.6-1.4-1.71.5-1.51.5-1.01.0-1.0
Patch foraging water rate 6 sec0.81.21.80.30.5-0.5-0.3-0.31.01.2-1.11.31.3-1.31.31.31.3-1.3-1.3-1.21.4-1.41.4-0.90.9-0.7
Seeking ratio, delayed vs. immediate footshock0.00.00.2-0.50.20.4-0.00.10.10.1-0.10.10.1-0.10.10.20.2-0.1-0.2-0.00.2-0.20.20.2-0.20.0
Distance traveled before self-admin0.10.10.60.7-0.2-0.6-0.80.2-0.0-0.1-0.00.00.0-0.00.10.0-0.1-0.1-0.2-0.10.2-0.20.2-0.40.4-0.2
Distance traveled after self-admin1.92.44.3-0.81.51.01.1-1.71.51.4-1.61.41.4-1.41.51.71.3-1.6-1.6-1.61.6-1.61.6-2.12.1-1.8
Extensor digitorum longus weight4.116.218.42.8-3.8-2.9-3.44.1-4.1-4.34.2-4.2-4.24.2-4.2-4.3-4.24.24.14.3-4.04.0-4.04.1-4.14.3
Bone: elastic displacement1.01.12.71.6-1.3-1.4-1.60.9-1.0-0.80.9-0.7-0.70.7-0.8-0.7-0.70.91.10.7-1.31.3-1.30.9-0.91.0
Bone: elastic work0.91.11.81.1-1.1-0.7-1.30.7-1.1-1.11.1-1.1-1.11.1-1.1-1.1-1.01.21.31.1-1.41.4-1.40.5-0.50.6
Bone: endosteal estimation0.51.12.20.3-0.8-0.4-0.20.1-1.1-1.21.1-1.3-1.31.3-1.2-1.5-1.31.41.31.5-1.31.3-1.30.2-0.20.1
Bone: endosteal perimeter0.20.41.10.0-0.40.1-0.2-0.1-0.6-0.80.6-0.8-0.80.8-0.8-1.0-0.81.00.81.0-0.70.7-0.7-0.10.1-0.1
Epididymis fat weight16.355.763.5-7.57.87.57.5-7.67.98.0-7.77.87.8-7.87.77.07.7-7.2-7.1-7.27.2-7.27.2-6.96.9-7.0
Delta time in closed arm before/after self-admin0.10.10.9-0.50.30.71.0-0.30.10.0-0.0-0.1-0.10.1-0.1-0.2-0.20.30.20.4-0.30.3-0.3-0.20.2-0.2
Delta time in open arm before/after self-admin0.20.20.60.1-0.3-0.1-0.20.2-0.3-0.30.4-0.3-0.30.3-0.4-0.4-0.20.30.40.3-0.40.4-0.40.8-0.80.5
Diff in mean of infusions in LGA sessions0.00.10.2-0.50.10.30.3-0.2-0.00.00.10.00.0-0.0-0.1-0.2-0.20.20.40.0-0.40.4-0.40.2-0.20.2
Delay discount exponential model param0.20.20.7-0.40.50.30.6-0.30.50.5-0.50.50.5-0.50.50.90.5-0.6-0.4-0.70.4-0.40.4-0.30.3-0.1
Extinction: sum of active levers before priming0.30.30.80.5-0.5-0.90.30.1-0.5-0.30.5-0.4-0.40.4-0.5-0.5-0.60.60.60.5-0.50.5-0.50.6-0.60.7
Active lever presses in extinction session 60.90.92.01.2-1.2-1.4-0.81.0-1.0-0.61.0-0.5-0.50.5-0.8-1.0-0.70.91.00.8-1.01.0-1.01.0-1.01.0
Bone: final force0.10.10.3-0.3-0.00.20.1-0.3-0.3-0.40.3-0.5-0.50.5-0.4-0.5-0.50.50.50.5-0.20.2-0.2-0.30.3-0.4
Bone: final moment0.10.20.4-0.2-0.10.20.0-0.3-0.3-0.50.3-0.6-0.60.6-0.5-0.5-0.50.50.50.5-0.30.3-0.3-0.40.4-0.4
Food consumed during 24 hour testing period0.10.20.3-0.2-0.10.40.00.2-0.4-0.50.4-0.6-0.60.6-0.4-0.4-0.60.30.40.4-0.30.3-0.30.3-0.30.3
Glucose0.30.51.6-1.30.91.21.0-0.80.70.6-0.70.60.5-0.50.60.50.5-0.5-0.5-0.50.4-0.40.4-0.80.8-0.7
Heart weight3.04.66.2-1.52.11.22.0-2.32.12.0-2.21.91.9-1.92.12.21.9-2.3-2.5-2.02.5-2.52.5-2.42.4-2.2
Delay discount hyperbolic model param0.10.10.5-0.10.30.10.3-0.00.30.3-0.30.40.4-0.40.40.70.4-0.5-0.3-0.60.3-0.30.3-0.10.10.1
Intermittent access intake day 1-15 change0.10.31.11.1-0.7-1.0-0.80.8-0.5-0.40.5-0.3-0.30.3-0.3-0.5-0.60.40.30.4-0.40.4-0.40.2-0.20.5
Intermittent access intake escalation0.00.10.50.7-0.4-0.7-0.50.4-0.2-0.10.2-0.0-0.00.0-0.0-0.2-0.30.0-0.00.1-0.00.0-0.0-0.10.10.1
Intermittent access intake escalation 20.00.00.10.2-0.1-0.30.00.2-0.1-0.20.1-0.2-0.20.2-0.10.0-0.4-0.1-0.20.20.1-0.10.1-0.10.1-0.1
Intermitt. access day 1 inactive lever presses0.51.83.31.1-1.3-1.1-1.31.5-1.3-1.31.3-1.3-1.31.3-1.3-1.3-1.11.21.31.2-1.31.3-1.31.6-1.61.8
Intermitt. access day 15 inactive lever presses3.26.69.91.5-2.1-1.1-1.72.0-2.7-3.02.7-3.1-3.13.1-2.9-2.8-2.92.52.52.6-2.62.6-2.62.7-2.72.5
Intermitt. access escalation Index1.21.78.0-2.71.82.72.8-1.71.00.6-0.90.40.4-0.40.61.10.3-0.8-0.8-1.00.8-0.80.8-0.80.8-0.9
Intermittent access day 1 total infusions3.35.36.62.6-2.5-2.2-2.52.5-2.4-2.22.4-2.1-2.12.1-2.3-2.4-2.02.22.22.0-2.32.3-2.32.5-2.52.4
Intermittent access day 15 total infusions1.72.64.82.2-1.9-2.0-1.91.9-1.7-1.51.7-1.4-1.41.4-1.6-1.6-1.51.41.41.3-1.51.5-1.51.5-1.51.6
Intermittent access terminal intake (last 3 days)2.83.76.82.6-2.2-2.3-2.42.2-2.0-1.81.9-1.7-1.71.7-1.8-1.8-1.81.71.61.6-1.71.7-1.71.8-1.81.9
Intermittent access total infusions3.13.78.02.8-2.3-2.5-2.52.4-1.9-1.51.8-1.4-1.41.4-1.6-2.0-1.31.71.71.6-1.81.8-1.81.9-1.91.9
Intermittent access day 1 locomotion2.02.53.91.9-1.8-1.9-1.81.7-1.6-1.31.6-1.3-1.31.3-1.5-1.6-1.31.41.41.3-1.51.5-1.51.9-1.92.0
Intermittent access day 15 total locomotion0.20.41.01.0-0.7-0.5-0.60.7-0.6-0.50.6-0.5-0.50.5-0.6-0.8-0.40.70.60.7-0.60.6-0.60.8-0.81.0
Intermittent access total locomotion0.70.82.81.7-1.2-1.4-1.01.0-0.8-0.30.8-0.3-0.30.3-0.6-1.0-0.30.80.80.7-0.80.8-0.81.1-1.11.4
Intermittent access standard deviation0.91.93.11.6-1.5-1.7-1.81.4-1.4-1.21.4-1.2-1.21.2-1.3-1.4-1.21.31.31.2-1.41.4-1.41.4-1.41.3
Left kidney weight0.00.10.30.4-0.1-0.6-0.2-0.10.10.3-0.10.30.4-0.40.20.00.3-0.1-0.2-0.10.3-0.30.3-0.10.1-0.2
Right kidney weight0.52.12.9-0.71.20.30.9-1.51.41.6-1.51.61.6-1.61.51.41.5-1.5-1.7-1.31.7-1.71.7-1.51.5-1.5
Cocaine induced anxiety0.20.20.50.1-0.3-0.10.40.1-0.5-0.50.5-0.6-0.60.6-0.6-0.5-0.70.50.50.5-0.50.5-0.50.5-0.50.5
Post-drug Anxiety1.51.62.4-1.41.41.41.4-1.61.31.2-1.21.21.2-1.21.21.11.1-1.2-1.2-1.21.3-1.31.3-1.21.2-1.3
Baseline Anxiety3.33.84.6-1.92.02.11.3-1.92.12.0-2.12.02.0-2.02.01.82.2-2.0-1.9-2.11.9-1.91.9-1.91.9-2.0
Tail length0.41.42.3-0.20.80.10.3-1.01.11.4-1.11.41.4-1.41.21.01.3-1.2-1.3-1.01.3-1.31.3-1.51.5-1.5
Length with tail1.56.69.4-1.12.00.71.3-2.22.62.9-2.63.13.1-3.12.82.52.9-2.7-2.7-2.52.7-2.72.7-2.82.8-2.8
Length without tail0.51.72.7-0.91.10.30.8-1.31.31.4-1.41.41.4-1.41.41.21.5-1.3-1.2-1.21.3-1.31.3-1.61.6-1.6
Times rat made contact with spout1.61.82.50.8-1.1-0.7-0.71.2-1.4-1.51.4-1.5-1.51.5-1.4-1.5-1.51.51.61.5-1.51.5-1.51.3-1.31.3
Lifetime Intake3.44.18.72.9-2.4-2.7-2.42.3-2.0-1.72.0-1.5-1.51.5-1.7-2.1-1.41.91.91.8-1.91.9-1.92.1-2.12.1
Liver weight, left3.86.37.5-1.92.31.72.2-2.62.52.5-2.52.52.5-2.52.52.52.6-2.6-2.6-2.52.7-2.72.7-2.62.6-2.7
Liver weight, right8.915.519.6-2.53.62.23.2-3.84.04.3-4.14.24.2-4.24.14.24.2-4.3-4.4-4.14.3-4.34.3-3.53.5-3.5
Locomotor activity0.40.71.7-1.01.01.11.3-1.30.80.8-0.80.70.7-0.70.70.70.8-0.7-0.6-0.70.7-0.70.7-0.70.7-0.8
Locomotor testing distance0.10.20.8-0.60.10.70.9-0.3-0.2-0.30.2-0.4-0.40.4-0.4-0.3-0.40.40.50.3-0.60.6-0.60.5-0.50.2
Locomotor testing rearing0.61.32.40.5-1.0-0.6-0.30.9-1.0-0.81.0-0.8-0.80.8-1.0-1.2-0.91.31.51.1-1.51.5-1.51.5-1.51.3
Locomotion in novel chamber0.10.10.3-0.10.10.20.10.00.30.4-0.20.40.4-0.40.30.10.6-0.2-0.2-0.40.2-0.20.20.2-0.20.1
Locomotion in novel chamber post-restriction2.94.86.1-2.22.22.12.2-2.02.32.5-2.22.52.4-2.42.22.22.4-2.2-2.0-2.31.9-1.91.9-2.02.0-1.7
Fecal boli incidents, locomotor time 10.40.62.51.5-1.0-1.6-1.11.0-0.8-0.70.7-0.6-0.60.6-0.6-0.4-0.60.30.40.4-0.60.6-0.60.5-0.50.9
Change in fecal boli incidents, locomotor task4.44.35.4-1.92.11.91.9-2.32.22.2-2.12.12.1-2.12.12.12.1-2.0-2.0-2.12.0-2.02.0-2.22.2-2.3
Time >=10cm from walls, locomotor time 10.10.10.70.9-0.2-0.6-0.50.00.10.2-0.20.30.3-0.30.30.40.3-0.2-0.4-0.40.4-0.40.4-0.30.3-0.1
Bouts of movement, locomotor time 11.41.63.0-0.3-0.70.2-0.51.2-1.2-1.61.2-1.6-1.61.6-1.4-1.7-1.51.41.31.7-1.21.2-1.21.2-1.21.0
Total resting periods, locomotor time 11.71.93.3-0.2-0.80.2-0.71.3-1.3-1.71.4-1.7-1.71.7-1.5-1.8-1.61.51.51.8-1.41.4-1.41.3-1.31.0
Rest time, locomotor task time 10.10.10.3-0.50.30.5-0.2-0.10.20.2-0.20.20.2-0.20.20.20.2-0.2-0.2-0.20.1-0.10.1-0.30.3-0.6
Distance moved, locomotor task time 10.71.11.7-0.10.80.21.0-1.21.01.2-1.11.21.2-1.21.11.31.1-1.2-1.2-1.21.2-1.21.2-0.80.8-0.7
Vertical activity count, locomotor time 10.20.50.8-0.20.50.20.7-0.90.70.7-0.70.70.7-0.70.70.90.7-0.8-0.8-0.90.9-0.90.9-0.60.6-0.7
Time >=10cm from walls, locomotor time 20.40.62.31.5-1.1-1.5-1.30.7-0.7-0.60.7-0.5-0.50.5-0.5-0.7-0.40.80.50.7-0.40.4-0.40.3-0.30.9
Bouts of movement, locomotor time 20.10.10.6-0.80.60.80.3-0.10.40.2-0.30.10.1-0.10.3-0.00.2-0.1-0.4-0.10.4-0.40.4-0.40.4-0.4
Total resting periods, locomotor time 20.10.10.7-0.90.40.80.10.20.1-0.2-0.0-0.2-0.20.2-0.1-0.4-0.20.3-0.10.30.0-0.00.0-0.10.1-0.1
Rest time, locomotor task time 20.91.11.7-0.1-0.60.1-0.80.9-1.0-1.21.1-1.3-1.31.3-1.2-1.3-1.31.21.11.2-1.21.2-1.20.9-0.90.7
Distance moved, locomotor task time 20.80.91.40.20.5-0.10.6-1.10.91.2-0.91.21.2-1.21.11.11.1-1.1-1.1-1.01.1-1.11.1-0.80.8-0.6
Vertical activity count, locomotor time 20.30.40.70.40.2-0.40.4-0.60.60.8-0.60.80.8-0.80.70.70.8-0.6-0.7-0.60.8-0.80.8-0.50.5-0.6
Light reinforcement 12.25.38.40.3-1.6-0.8-0.91.8-2.3-2.82.4-2.9-2.92.9-2.6-2.6-2.92.52.42.6-2.32.3-2.32.3-2.31.8
Light reinforcement 22.43.65.71.0-1.6-1.1-1.51.7-2.0-2.32.0-2.4-2.32.3-2.1-2.0-2.42.01.92.2-1.81.8-1.81.5-1.51.5
Bone: marrow area0.51.12.20.3-0.8-0.4-0.20.1-1.1-1.21.1-1.3-1.31.3-1.2-1.5-1.31.41.31.5-1.31.3-1.30.2-0.20.1
Bone: maximum diameter0.81.52.8-0.1-0.60.00.10.1-1.2-1.51.2-1.7-1.71.7-1.5-1.7-1.61.61.51.7-1.31.3-1.30.1-0.10.1
Bone: maximum force0.10.20.4-0.0-0.30.0-0.30.0-0.4-0.60.4-0.6-0.60.6-0.5-0.6-0.60.60.60.6-0.40.4-0.40.0-0.0-0.0
Bone: maximum moment0.20.30.60.1-0.3-0.0-0.40.0-0.5-0.70.5-0.8-0.80.8-0.6-0.7-0.70.70.70.7-0.50.5-0.50.0-0.00.0
Mean time between licks in bursts1.53.74.4-1.31.81.51.9-2.01.92.0-2.01.91.9-1.92.02.11.9-2.1-2.0-2.12.0-2.02.0-1.91.9-1.9
Mean num. licks in bursts0.40.62.11.1-1.0-1.4-1.31.2-0.7-0.50.6-0.4-0.40.4-0.5-0.4-0.40.40.60.4-0.70.7-0.70.7-0.70.7
Cd content in liver0.00.00.2-0.30.10.00.4-0.20.0-0.00.0-0.0-0.00.0-0.0-0.0-0.10.10.10.0-0.10.1-0.1-0.10.1-0.0
Co content in liver5.66.67.92.5-2.6-2.4-2.42.3-2.7-2.82.6-2.8-2.82.8-2.7-2.7-2.72.72.62.7-2.52.5-2.52.1-2.12.1
Cu content in liver0.20.20.70.8-0.6-0.7-0.80.3-0.4-0.40.4-0.3-0.30.3-0.3-0.3-0.40.30.30.3-0.20.2-0.20.4-0.40.4
Fe content in liver1.21.42.91.5-1.5-1.6-1.70.9-1.2-1.01.2-1.0-1.01.0-1.1-0.9-1.01.01.20.9-1.21.2-1.21.3-1.31.0
K content in liver0.40.40.8-0.50.10.40.3-0.6-0.4-0.70.4-0.9-0.90.9-0.6-0.7-0.90.60.40.7-0.40.4-0.4-0.60.6-0.8
Mg content in liver0.40.40.8-0.50.10.30.3-0.7-0.4-0.70.4-0.9-0.90.9-0.6-0.7-0.90.60.50.7-0.40.4-0.4-0.60.6-0.7
Mn content in liver0.30.31.9-1.40.51.21.2-0.60.0-0.10.0-0.3-0.30.3-0.2-0.4-0.30.40.50.4-0.50.5-0.5-0.50.5-0.6
Na content in liver0.80.82.91.7-1.2-1.5-1.60.8-1.0-0.80.9-0.8-0.80.8-0.8-0.7-0.90.60.50.7-0.50.5-0.50.7-0.70.6
Rb content in liver0.10.10.6-0.50.30.40.8-0.70.10.0-0.1-0.1-0.10.1-0.1-0.0-0.10.00.10.0-0.00.0-0.0-0.60.6-0.6
Se content in liver0.10.10.3-0.60.40.50.4-0.50.30.4-0.30.40.4-0.40.30.20.3-0.2-0.2-0.20.1-0.10.1-0.10.1-0.0
Sr content in liver0.20.20.30.60.0-0.2-0.5-0.10.20.3-0.30.40.4-0.40.40.40.4-0.5-0.5-0.40.5-0.50.5-0.30.3-0.3
Zn content in liver0.91.02.3-0.91.10.90.7-1.51.00.8-1.00.80.8-0.80.90.90.8-0.9-1.0-0.91.0-1.01.0-1.41.4-1.5
Bone: minimum diameter0.20.41.4-1.00.81.01.1-1.10.40.2-0.40.10.1-0.10.20.10.1-0.1-0.2-0.10.3-0.30.3-1.21.2-1.2
Time in familiar zone, hab. session 10.80.82.0-1.11.00.81.4-1.30.90.8-0.80.70.7-0.70.80.70.7-0.7-0.7-0.70.7-0.70.7-1.21.2-1.2
Time in novel zone, hab. session 10.40.40.9-0.40.50.50.30.20.70.9-0.60.90.9-0.90.80.70.9-0.6-0.4-0.70.5-0.50.50.0-0.0-0.0
Total zone transitions, hab. session 10.10.20.50.2-0.3-0.5-0.30.5-0.4-0.40.4-0.4-0.40.4-0.4-0.4-0.40.40.50.4-0.30.3-0.30.7-0.70.5
Total locomotion distance, hab. session 10.20.31.10.9-0.6-1.0-0.30.2-0.5-0.60.5-0.5-0.50.5-0.5-0.6-0.50.50.50.6-0.40.4-0.40.4-0.40.2
Locomotion velocity, hab. session 10.91.32.01.4-1.2-1.4-1.00.8-1.2-1.31.2-1.3-1.31.3-1.2-1.1-1.31.11.21.1-1.01.0-1.00.9-0.90.8
Time in familiar zone, hab. session 20.10.10.4-0.60.30.60.4-0.00.0-0.1-0.0-0.1-0.10.1-0.1-0.2-0.10.20.20.2-0.20.2-0.2-0.00.00.1
Time in novel zone, hab. session 20.50.50.70.00.40.00.4-0.70.60.8-0.70.80.8-0.80.70.80.8-0.8-0.7-0.80.8-0.80.8-0.70.7-0.8
Total zone transitions, hab. session 20.10.10.7-0.90.20.40.2-0.2-0.1-0.30.1-0.4-0.40.4-0.2-0.3-0.40.30.30.3-0.20.2-0.2-0.20.2-0.3
Total locomotion distance, hab. session 20.10.20.4-0.70.10.60.10.0-0.2-0.50.3-0.6-0.60.6-0.4-0.4-0.60.40.30.4-0.20.2-0.20.0-0.0-0.1
Locomotion velocity, hab. session 20.20.30.6-0.5-0.10.4-0.10.2-0.4-0.70.5-0.8-0.80.8-0.6-0.6-0.80.50.50.6-0.40.4-0.40.3-0.30.1
Novel to familiar place preference ratio1.11.21.5-0.91.10.71.1-0.91.11.1-1.11.11.1-1.11.11.11.1-1.1-1.1-1.11.2-1.21.2-1.01.0-1.1
Novelty place preference1.61.82.1-1.11.30.91.4-1.11.41.4-1.41.41.4-1.41.41.41.4-1.4-1.4-1.41.4-1.41.4-1.21.2-1.3
Time in novel zone, NPP test1.81.92.3-1.11.30.91.4-1.11.41.5-1.41.51.5-1.51.51.51.5-1.4-1.4-1.51.5-1.51.5-1.21.2-1.3
Total zone transitions, NPP test1.31.82.50.9-1.3-1.2-1.51.2-1.4-1.61.4-1.5-1.51.5-1.4-1.2-1.51.31.31.2-1.21.2-1.21.4-1.41.3
Total locomotion distance, NPP test1.72.43.01.1-1.5-1.3-1.51.6-1.6-1.71.6-1.7-1.71.7-1.6-1.5-1.71.51.51.5-1.41.4-1.41.6-1.61.5
Locomotion velocity, NPP test2.83.94.91.3-1.8-1.5-1.81.8-2.0-2.22.0-2.2-2.22.2-2.1-2.0-2.22.02.02.0-2.02.0-2.01.9-1.91.8
Intraocular pressure6.08.611.5-2.53.02.53.4-3.13.13.1-3.02.92.9-2.93.02.93.1-2.9-2.8-3.02.8-2.82.8-2.92.9-3.0
Delta distance traveled before/after self-admin1.92.03.2-1.51.61.81.7-1.61.41.2-1.41.11.1-1.11.31.51.2-1.4-1.3-1.41.4-1.41.4-1.41.4-1.3
Delta ambulatory time before/after self-admin0.30.41.5-1.00.81.01.2-1.00.60.3-0.50.20.2-0.20.40.60.3-0.5-0.4-0.50.5-0.50.5-0.70.7-0.7
Parametrial fat weight13.030.644.6-6.36.36.75.5-5.85.75.0-5.64.84.8-4.85.35.34.9-5.4-5.6-5.25.7-5.75.7-5.65.6-5.6
Pavlov. Cond. lever latency1.31.62.6-0.61.10.80.7-0.71.31.5-1.31.61.6-1.61.51.41.6-1.4-1.3-1.41.3-1.31.3-1.01.0-0.7
Pavlov. Cond. magazine entry latency0.00.10.2-0.4-0.00.10.4-0.1-0.2-0.30.2-0.4-0.40.4-0.3-0.2-0.40.20.20.2-0.10.1-0.10.0-0.0-0.1
Pavlov. Cond. change in total contacts0.00.00.10.1-0.1-0.30.2-0.1-0.2-0.20.2-0.3-0.30.3-0.2-0.1-0.20.10.10.1-0.10.1-0.10.1-0.1-0.2
Pavlov. Cond. index score0.40.51.2-0.1-0.5-0.30.10.1-0.8-1.00.8-1.1-1.11.1-0.9-0.8-1.10.80.80.8-0.70.7-0.70.4-0.40.1
Pavlov. Cond. latency score0.40.61.2-0.2-0.4-0.10.20.1-0.7-1.00.8-1.1-1.11.1-0.9-0.8-1.10.80.80.8-0.70.7-0.70.4-0.40.1
Pavlov. Cond. lever contacts0.81.01.70.5-0.9-0.7-0.50.5-1.1-1.21.1-1.3-1.31.3-1.1-1.1-1.31.11.01.1-1.01.0-1.00.7-0.70.3
Pavlov. Cond. magazine entry number0.30.30.80.10.40.1-0.2-0.20.60.8-0.60.90.9-0.90.80.60.9-0.6-0.6-0.60.5-0.50.5-0.30.3-0.1
Pavlov. Cond. intertrial magazine entries1.51.83.21.8-1.5-1.6-1.81.2-1.3-1.21.3-1.2-1.21.2-1.2-1.2-1.21.11.11.2-1.21.2-1.21.6-1.61.6
Pavlov. Cond. lever-magazine prob. diff.0.91.22.10.4-0.9-0.6-0.30.6-1.2-1.41.2-1.4-1.41.4-1.3-1.2-1.41.21.21.2-1.11.1-1.10.8-0.80.5
Pavlov. Cond. response bias1.01.22.00.7-1.1-0.9-0.60.7-1.2-1.41.2-1.4-1.41.4-1.3-1.1-1.41.11.11.1-1.11.1-1.10.8-0.80.6
Pavlov. Cond. lever latency1.42.03.1-1.21.30.81.5-1.51.41.4-1.41.31.3-1.31.41.51.4-1.5-1.5-1.51.1-1.11.1-1.81.8-1.5
Pavlov. Cond. magazine entry latency0.30.30.50.2-0.40.3-0.50.5-0.5-0.60.5-0.6-0.60.6-0.6-0.6-0.60.70.70.6-0.40.4-0.40.6-0.60.5
Pavlov. Cond. change in total contacts0.61.01.90.5-0.8-0.1-0.91.2-0.9-1.00.9-0.9-0.90.9-0.9-1.0-0.91.21.21.0-0.90.9-0.91.4-1.41.2
Pavlov. Cond. index score1.11.52.21.0-1.1-0.4-1.31.3-1.2-1.31.2-1.2-1.21.2-1.2-1.3-1.21.41.41.3-1.01.0-1.01.5-1.51.3
Pavlov. Cond. latency score1.21.62.31.0-1.1-0.5-1.41.4-1.2-1.31.3-1.2-1.21.2-1.2-1.3-1.31.51.41.3-1.11.1-1.11.5-1.51.4
Pavlov. Cond. lever contacts1.01.32.31.0-1.1-0.6-1.31.2-1.1-1.11.2-1.1-1.11.1-1.1-1.3-1.11.31.21.3-0.90.9-0.91.5-1.51.3
Pavlov. Cond. magazine entry number0.20.20.4-0.10.2-0.50.3-0.20.40.5-0.40.50.5-0.50.40.50.5-0.6-0.6-0.50.3-0.30.3-0.60.6-0.4
Pavlov. Cond. intertrial magazine entries3.55.26.1-2.12.31.82.2-2.02.42.5-2.42.42.4-2.42.42.32.4-2.4-2.5-2.32.2-2.22.2-2.32.3-2.2
Pavlov. Cond. lever-magazine prob. diff.0.71.01.40.6-0.8-0.1-1.01.0-1.0-1.01.0-1.0-1.01.0-1.0-1.1-1.01.21.21.1-0.80.8-0.81.2-1.21.0
Pavlov. Cond. response bias1.62.13.31.2-1.4-0.7-1.61.5-1.5-1.51.5-1.5-1.51.5-1.5-1.6-1.51.61.51.6-1.11.1-1.11.8-1.81.5
Time in closed arm before self-admin0.60.71.4-0.70.80.40.8-0.81.01.0-0.91.11.1-1.11.00.81.2-0.8-0.7-0.80.8-0.80.8-1.01.0-0.3
Time in closed arm after self-admin1.11.11.9-0.91.00.91.4-0.91.21.3-1.11.31.3-1.31.21.01.4-0.9-0.8-0.90.8-0.80.8-1.21.2-0.5
Time in open arm before self-admin0.00.00.2-0.1-0.00.2-0.00.1-0.2-0.20.1-0.2-0.20.2-0.2-0.2-0.40.1-0.00.2-0.10.1-0.1-0.00.0-0.0
Time in open arm after self-admin1.11.21.80.6-0.9-0.5-0.60.8-1.2-1.21.2-1.3-1.31.3-1.3-1.2-1.41.11.01.1-1.01.0-1.01.3-1.31.0
Bone: periosteal estimation0.71.62.90.3-0.8-0.4-0.20.2-1.3-1.61.3-1.7-1.71.7-1.5-1.7-1.61.61.41.7-1.31.3-1.30.2-0.20.1
Bone: periosteal perimeter0.30.51.10.0-0.40.0-0.20.0-0.7-0.90.7-1.0-1.01.0-0.9-1.0-1.01.00.81.0-0.70.7-0.70.0-0.00.0
Bone: post-yield work1.21.82.61.4-1.5-1.6-1.51.5-1.3-1.21.3-1.1-1.11.1-1.2-1.1-1.11.21.31.1-1.31.3-1.31.6-1.61.6
Progressive ratio test 1 active lever presses1.92.45.52.3-1.9-2.2-2.01.7-1.5-1.11.5-1.0-1.01.0-1.3-1.7-1.01.51.41.5-1.51.5-1.51.7-1.71.4
Progressive ratio test 1 breakpoint2.02.45.52.4-1.9-2.2-2.01.7-1.5-1.11.5-1.0-1.01.0-1.3-1.7-0.91.51.41.5-1.51.5-1.51.7-1.71.4
Progressive ratio test 1 inactive lever presses3.75.39.73.1-2.6-2.7-2.42.4-2.4-2.02.3-1.9-1.91.9-2.2-2.3-1.92.12.12.1-2.22.2-2.22.4-2.42.5
Progressive ratio test 2 active lever presses0.91.05.12.3-1.4-2.1-1.61.3-0.9-0.50.8-0.3-0.30.3-0.6-0.7-0.30.70.60.6-0.70.7-0.70.8-0.80.7
Progressive ratio test 2 breakpoint0.70.94.72.2-1.3-2.0-1.51.2-0.8-0.40.7-0.2-0.20.2-0.5-0.6-0.20.50.50.5-0.60.6-0.60.7-0.70.6
Progressive ratio test 2 inactive lever presses1.82.96.22.5-2.0-2.2-1.81.8-1.7-1.51.7-1.4-1.41.4-1.5-1.8-1.41.61.61.6-1.51.5-1.51.7-1.71.7
Incentive Sensitization - Responses0.30.42.21.4-0.9-1.5-0.90.7-0.6-0.40.6-0.4-0.40.4-0.4-0.3-0.50.30.30.2-0.40.4-0.40.3-0.30.4
Incentive Sensitization - Breakpoint0.20.21.61.2-0.8-1.3-0.70.6-0.4-0.30.4-0.3-0.30.3-0.3-0.1-0.40.10.20.0-0.20.2-0.20.1-0.10.2
Sum of active levers in priming session hrs 5-60.30.30.6-0.60.10.60.7-0.5-0.4-0.60.4-0.8-0.80.8-0.6-0.3-0.80.40.40.5-0.30.3-0.30.3-0.30.1
Progressive ratio0.00.00.2-0.30.20.30.4-0.20.10.1-0.10.00.0-0.00.1-0.10.3-0.00.0-0.00.0-0.00.0-0.20.2-0.1
Food seeking constrained by brief footshock5.16.314.33.4-3.1-3.8-2.82.8-2.5-2.22.4-2.0-2.02.0-2.2-2.0-2.02.12.32.0-2.32.3-2.32.7-2.72.5
Seeking ratio, punishment vs. effort0.50.82.61.4-1.1-1.6-1.31.0-0.9-0.70.8-0.6-0.60.6-0.7-0.4-0.90.60.60.5-0.70.7-0.71.0-1.00.7
Retroperitoneal fat weight24.1102.7145.8-11.911.312.111.3-10.710.610.0-10.39.79.7-9.79.99.59.7-9.6-9.6-9.59.5-9.59.5-9.59.5-9.8
Reaction time number correct0.40.71.20.4-0.7-0.3-0.70.9-0.8-1.10.8-1.1-1.01.0-0.9-0.7-1.00.80.80.7-0.80.8-0.80.9-0.90.7
Reaction time mean minus median0.00.10.30.5-0.3-0.3-0.30.4-0.10.00.10.10.1-0.10.00.00.10.00.00.1-0.20.2-0.20.5-0.50.5
Reaction time mean minus median AUC0.00.00.10.00.10.10.1-0.10.20.2-0.20.20.3-0.30.30.40.4-0.3-0.3-0.20.1-0.10.10.1-0.10.1
Reaction time num false alarms0.40.64.0-2.01.11.81.6-1.00.50.1-0.4-0.1-0.10.10.10.3-0.0-0.2-0.1-0.30.2-0.20.2-0.60.6-0.8
Reaction time num false alarms AUC0.40.64.2-2.01.21.91.6-1.10.50.1-0.4-0.1-0.10.10.10.3-0.0-0.2-0.1-0.30.2-0.20.2-0.50.5-0.7
Reaction time trials correct on left0.40.71.20.4-0.7-0.3-0.70.9-0.8-1.10.8-1.1-1.01.0-0.9-0.7-1.00.80.80.7-0.80.8-0.80.9-0.90.7
Reaction time trials on left0.40.71.20.4-0.7-0.3-0.70.9-0.9-1.10.9-1.1-1.11.1-0.9-0.8-1.00.90.80.7-0.80.8-0.80.9-0.90.7
Reaction time mean0.91.42.10.10.8-0.10.6-1.11.21.3-1.21.31.3-1.31.31.31.4-1.4-1.5-1.21.4-1.41.4-1.11.1-1.2
Reaction time mean AUC0.71.21.90.10.7-0.20.5-1.01.11.2-1.11.21.2-1.21.21.21.3-1.3-1.4-1.11.3-1.31.3-1.01.0-1.1
Median of all reaction times1.21.72.50.00.9-0.10.7-1.31.31.3-1.31.41.4-1.41.41.31.5-1.5-1.6-1.31.5-1.51.5-1.31.3-1.4
Reaction time omissions0.10.10.6-0.50.10.10.8-0.3-0.1-0.20.2-0.3-0.30.3-0.3-0.4-0.30.20.20.2-0.20.2-0.20.3-0.30.0
Reaction time false alarm rate0.71.04.3-2.11.41.91.8-1.40.90.6-0.80.40.4-0.40.60.60.4-0.6-0.5-0.70.5-0.50.5-1.01.0-1.1
Reaction time premature initiation rate0.10.20.3-0.40.40.40.0-0.10.40.5-0.40.60.6-0.60.50.50.5-0.4-0.4-0.40.5-0.50.50.1-0.1-0.1
Reaction time premature initiations0.00.00.2-0.20.00.2-0.30.4-0.0-0.10.0-0.0-0.00.0-0.00.0-0.10.00.0-0.00.0-0.00.00.5-0.50.3
Std. dev. reaction times0.20.30.60.10.40.10.4-0.40.60.6-0.60.60.7-0.70.70.70.8-0.7-0.7-0.60.6-0.60.6-0.40.4-0.6
Reaction time trials completed0.40.71.20.4-0.7-0.3-0.70.9-0.9-1.10.9-1.1-1.11.1-0.9-0.8-1.00.90.80.7-0.80.8-0.80.9-0.90.7
Reaction time trials AUC0.50.91.50.5-0.8-0.4-0.91.1-1.0-1.21.0-1.2-1.21.2-1.0-0.9-1.10.90.90.8-0.90.9-0.91.1-1.10.9
Run reversals in cocaine runway, females0.10.10.70.8-0.3-0.8-0.70.30.00.2-0.10.30.3-0.30.20.40.3-0.4-0.3-0.50.2-0.20.2-0.20.2-0.1
Run reversals in cocaine runway, males0.20.21.01.0-0.7-1.0-1.00.8-0.4-0.10.3-0.0-0.00.0-0.2-0.1-0.00.20.30.1-0.30.3-0.30.4-0.40.3
Latency to leave start box in cocaine runway0.70.81.41.1-1.0-0.9-1.20.8-0.9-0.80.9-0.7-0.70.7-0.8-0.9-0.90.90.90.8-0.90.9-0.91.0-1.00.7
Latency to leave start box in cocaine runway, F0.20.20.50.5-0.5-0.2-0.40.2-0.5-0.40.5-0.4-0.40.4-0.5-0.5-0.70.50.50.5-0.50.5-0.50.6-0.60.6
Latency to leave start box in cocaine runway, M0.40.31.81.0-0.8-0.9-1.30.9-0.5-0.40.5-0.2-0.20.2-0.3-0.4-0.20.40.40.4-0.40.4-0.40.6-0.60.1
Std. dev. time between licks in bursts0.40.52.7-1.10.91.21.6-1.20.50.3-0.50.10.1-0.10.30.20.1-0.4-0.6-0.20.6-0.60.6-0.70.7-0.7
Total sessions with >9 infusions1.41.74.42.1-1.7-2.1-1.71.6-1.2-0.91.2-0.8-0.80.8-1.0-1.4-0.71.21.31.1-1.21.2-1.21.3-1.31.3
Short access day 1 total inactive lever presses6.68.710.53.2-3.0-2.9-2.12.5-3.2-3.13.1-3.2-3.23.2-3.1-3.0-3.02.92.92.8-2.82.8-2.82.8-2.82.9
Short access day 10 total inactive lever presses1.53.64.70.9-1.7-1.0-1.61.8-2.0-2.11.9-2.2-2.22.2-2.0-2.0-1.91.91.91.8-2.02.0-2.02.1-2.12.1
Short access day 1 total infusions4.45.98.12.8-2.7-2.6-2.22.4-2.4-2.22.4-2.1-2.12.1-2.3-2.7-2.02.52.62.2-2.62.6-2.62.5-2.52.4
Short access day 10 total infusions2.73.47.92.8-2.2-2.7-2.22.0-1.9-1.61.8-1.5-1.51.5-1.6-1.9-1.31.61.71.5-1.71.7-1.71.8-1.81.8
Short access total infusions1.82.35.42.3-1.9-2.2-1.61.6-1.4-1.11.4-1.1-1.11.1-1.2-1.7-0.91.41.41.2-1.41.4-1.41.6-1.61.6
Short access day 1 locomotion3.44.36.42.4-2.3-2.0-2.32.5-2.0-1.72.0-1.6-1.61.6-1.9-2.3-1.62.12.11.9-2.12.1-2.12.2-2.22.3
Short access day 10 total locomotion1.22.34.01.4-1.5-1.4-1.91.9-1.5-1.41.5-1.3-1.31.3-1.4-1.6-1.21.41.31.5-1.31.3-1.31.7-1.72.0
Short access total locomotion0.50.62.01.4-1.0-1.3-1.11.0-0.6-0.30.6-0.3-0.30.3-0.4-0.8-0.10.60.60.5-0.60.6-0.60.9-0.91.0
One hour access (0.3 mA shock)1.92.15.42.3-1.8-2.3-2.01.8-1.4-1.31.4-1.2-1.21.2-1.2-1.4-1.11.31.21.4-1.21.2-1.21.2-1.21.2
Compulsive drug intake1.51.84.1-2.01.61.52.0-1.81.20.9-1.20.80.8-0.81.01.70.9-1.3-1.2-1.41.3-1.31.3-1.41.4-1.4
One hour access (shock baseline)2.53.99.73.1-2.4-2.7-2.82.5-1.9-1.61.9-1.5-1.51.5-1.6-2.1-1.51.81.61.9-1.71.7-1.71.7-1.71.7
Social response proportion0.30.31.00.30.2-0.3-0.3-0.40.40.6-0.40.60.6-0.60.50.40.6-0.4-0.5-0.20.4-0.40.4-0.90.9-1.0
Social responses0.10.20.7-0.70.50.60.1-0.40.40.3-0.40.30.3-0.30.3-0.00.3-0.2-0.40.10.4-0.40.4-0.60.6-0.8
Social time0.20.30.50.10.3-0.20.0-0.20.50.6-0.50.70.7-0.70.60.50.6-0.5-0.5-0.50.6-0.60.6-0.50.5-0.5
Soleus weight4.212.414.52.7-3.4-3.0-3.23.3-3.6-3.83.6-3.7-3.73.7-3.6-3.7-3.83.73.63.7-3.53.5-3.53.4-3.43.5
Bone: stiffness0.00.00.2-0.40.10.30.10.2-0.1-0.20.1-0.2-0.20.2-0.1-0.2-0.20.10.10.20.2-0.20.20.1-0.10.1
Tibialis anterior weight3.110.713.51.7-2.9-1.8-2.53.0-3.4-3.73.4-3.7-3.63.6-3.5-3.7-3.63.63.43.7-3.33.3-3.33.1-3.13.3
Time to tail flick, vehicle, before self-admin0.70.81.80.00.50.20.4-0.20.91.2-0.91.41.3-1.31.10.91.2-0.9-0.8-1.20.7-0.70.7-0.70.7-0.6
Time to tail flick, vehicle, after self-admin3.14.15.8-1.82.02.11.6-1.72.22.3-2.22.32.3-2.32.21.92.4-1.9-1.8-2.21.7-1.71.7-1.91.9-1.9
Time to tail flick, test, before self-admin0.10.10.30.6-0.4-0.20.10.3-0.3-0.10.3-0.0-0.00.0-0.2-0.3-0.10.20.20.2-0.30.3-0.30.4-0.40.5
Time to tail flick, test, after self-admin0.30.31.21.0-0.7-1.1-0.90.9-0.4-0.30.4-0.1-0.10.1-0.3-0.3-0.10.30.40.3-0.30.3-0.30.3-0.30.5
Delta time to tail flick, vehicle, before/after SA0.20.21.3-1.10.61.10.5-0.60.40.2-0.40.20.2-0.20.30.20.3-0.1-0.1-0.20.1-0.10.1-0.30.3-0.4
Delta time to tail flick, test, before/after SA1.61.72.81.5-1.4-1.6-1.71.4-1.3-1.41.3-1.3-1.31.3-1.3-1.2-1.31.21.21.3-1.11.1-1.11.0-1.01.2
Tibia length2.57.010.0-1.72.41.32.6-2.72.62.7-2.72.62.6-2.62.72.72.6-2.7-2.7-2.72.7-2.72.7-3.13.1-3.2
Ambulatory time before self-admin0.10.10.60.7-0.3-0.7-0.80.3-0.2-0.20.1-0.1-0.10.1-0.1-0.1-0.2-0.0-0.10.00.1-0.10.1-0.20.20.1
Ambulatory time after self-admin1.21.52.7-0.61.10.50.8-1.31.11.0-1.21.01.0-1.01.21.40.9-1.4-1.4-1.41.4-1.41.4-1.61.6-1.4
Bone: tissue strength0.90.91.2-0.50.80.70.5-0.70.91.0-1.01.01.0-1.01.01.11.0-1.1-1.0-1.11.0-1.01.0-0.90.9-0.9
Total heroin consumption2.52.93.91.5-1.7-1.7-1.11.5-1.8-1.71.8-1.8-1.71.7-1.8-1.8-2.01.81.81.8-1.71.7-1.71.6-1.61.7
Bone: trabecular number2.84.76.61.7-2.1-1.9-1.71.5-2.3-2.52.3-2.6-2.62.6-2.4-2.3-2.52.32.42.3-2.32.3-2.31.4-1.41.3
Bone: trabecular spacing2.63.54.9-1.01.60.91.3-1.31.92.2-1.92.22.2-2.22.12.22.1-2.2-2.2-2.22.2-2.22.2-1.11.1-1.1
Bone: trabecular thickness0.60.81.30.5-0.7-0.6-0.50.1-0.9-1.10.9-1.1-1.11.1-1.0-1.0-1.11.01.11.0-1.11.1-1.10.1-0.10.0
Bone: trabecular tissue density0.40.50.90.9-0.8-0.7-0.70.8-0.8-0.80.7-0.8-0.80.8-0.7-0.7-0.80.60.40.7-0.50.5-0.50.9-0.90.8
Water consumed over 24 hours0.30.41.0-0.4-0.10.70.10.0-0.5-0.90.6-1.0-1.01.0-0.7-0.9-0.90.70.60.9-0.50.5-0.50.3-0.30.3
Number of responses in last shaping day0.50.52.91.7-1.0-1.3-0.50.6-0.7-0.30.7-0.2-0.20.2-0.5-1.1-0.50.80.70.9-0.60.6-0.60.5-0.50.3