Nanos1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Nanos1	0.1	0.05	4.7e-07	0.06	0.08	0.08	0.08	2.3e-06	9.6e-08	1.4e-07	3.2e-08
2	Liver	gene expression	Nanos1	0.08	0.04	6.9e-08	0.05	0.05	0.04	0.04	1.1e-06	5.6e-06	1.4e-05	1.2e-05
3	PL	gene expression	Nanos1	0.1	0.06	8.7e-06	0.05	0.04	0.05	0.04	1.8e-06	1.4e-05	8.0e-06	2.0e-05
4	pVTA	gene expression	Nanos1	0.12	0.08	3.3e-03	0.09	0.07	0.05	0.09	1.0e-04	4.6e-04	3.2e-03	1.3e-04
5	BLA	gene expression	Nanos1	0.12	0.08	2.6e-04	0.04	0.05	0.06	0.04	1.9e-03	9.7e-04	5.1e-04	2.0e-03
6	NAcc	gene expression	Nanos1	0.05	0.03	5.8e-05	0.02	0.04	0.05	0.05	6.8e-04	1.2e-05	4.3e-06	2.7e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	2.7	4.6	12.2	-3.5	1.7	2.8	1.4	1.0	-1.2
Area under the delay curve	0.6	0.7	1.2	0.7	0.9	-1.0	0.6	-0.5	1.1
BMI with tail	12.3	39.8	93.9	-9.7	9.7	5.6	4.2	0.5	1.4
BMI without tail	9.1	18.7	46.0	-6.8	5.7	4.2	3.9	1.3	0.3
Body weight	11.4	47.9	119.0	-10.9	9.8	6.6	5.0	1.5	1.0
Weight adjusted by age	1.7	1.9	4.6	-2.2	2.0	0.9	0.9	0.7	0.7
Bone surface	2.1	3.7	10.1	-3.2	1.9	2.4	1.3	1.0	-0.6
Bone volume	2.7	4.7	12.7	-3.6	2.8	2.4	1.3	0.3	-0.2
Breakpoint value in progressive ratio session	0.3	0.3	1.0	-0.9	0.2	0.2	1.0	0.1	0.2
Number of licking bursts	0.9	1.0	1.7	-0.7	-0.6	1.0	1.3	1.2	-1.0
Context. condit. distance diff. score	0.1	0.2	0.3	-0.5	0.4	0.6	0.2	0.1	-0.5
Locomotion velocity, session 1	0.7	0.7	2.3	0.6	-1.3	0.1	0.0	1.5	-0.3
Locomotion distance, session 1	1.0	1.2	3.3	1.8	-0.3	-1.4	-1.3	-0.4	0.5
Locomotion velocity, session 2	0.8	0.9	2.1	1.5	-0.6	-1.0	-1.4	-0.3	0.4
Locomotion distance, session 2	0.6	0.9	2.4	-0.2	1.5	-0.4	-1.0	-0.9	0.9
Locomotion velocity, session 3	0.8	0.9	1.9	1.4	-1.2	-1.1	-0.9	0.3	-0.2
Locomotion distance, session 3	0.4	0.4	0.7	0.8	-0.8	-0.5	-0.8	0.3	-0.0
Stereotopy head waving bouts, day 3	0.7	0.8	1.5	1.2	0.0	-1.2	-0.8	-0.7	0.9
Stereotopy head waving duration, day 3	1.2	1.4	2.6	1.6	-0.0	-1.6	-0.7	-1.2	1.2
Locomotion velocity, session 7	0.1	0.1	0.2	-0.1	0.2	0.1	0.2	0.3	-0.5
Locomotion distance, session 7	0.4	0.5	1.6	-1.2	0.9	0.7	-0.3	0.2	-0.2
Stereotopy head waving bouts, day 7	0.4	0.4	1.6	0.8	-0.4	-0.5	1.3	-0.1	0.0
Stereotopy head waving duration, day 7	0.7	0.8	2.2	1.3	-0.7	-0.7	1.5	-0.1	-0.1
Locomotion velocity, session 8	0.7	0.8	2.2	-0.1	-1.5	0.5	-0.2	0.7	-1.3
Locomotion distance, session 8	0.2	0.3	0.5	-0.6	-0.0	0.7	-0.6	0.7	-0.6
Degree of sensitization distance	1.2	1.3	3.9	-2.0	1.2	1.3	0.5	-0.0	-0.3
Degree of sensitization stereotypy	0.5	0.5	2.6	0.5	0.1	-0.3	1.6	-0.4	-0.0
Conditioned locomotion	0.2	0.3	0.9	0.6	-0.5	-0.5	0.0	-0.9	0.1
Cocaine response after cond. corrected	2.6	2.9	9.5	1.8	-0.2	-1.5	-3.1	-1.4	0.8
Cocaine response after cond. not corrected	1.9	2.1	6.6	1.6	-1.4	-1.0	-2.6	-0.6	-0.0
Cocaine response before conditioning	2.7	3.3	5.3	-0.9	-2.3	1.5	1.7	2.2	-1.9
Saline control response	1.3	1.7	3.2	1.6	-0.5	-1.5	-0.8	-1.8	1.1
Bone: connectivity density	0.8	1.3	2.6	-1.6	0.5	1.5	0.6	0.8	-1.1
Bone: cortical apparent density	3.9	5.2	11.7	3.4	-2.2	-2.3	-2.7	-1.4	-0.0
Bone: cortical area	4.4	6.7	15.8	-4.0	3.8	2.3	2.0	-0.2	0.6
Bone: cortical porosity	1.0	1.1	2.5	-1.6	0.5	1.1	1.0	1.2	-0.5
Bone: cortical porosity	1.4	1.6	3.5	-1.9	0.8	1.3	1.4	1.2	-0.4
Bone: cortical thickness	2.4	4.0	12.3	-2.8	3.5	1.2	0.7	-1.0	1.1
Bone: cortical thickness	2.8	3.3	9.9	-1.0	3.1	-0.6	-0.2	-1.8	2.3
Bone: cortical tissue density	4.1	5.4	12.3	3.5	-2.4	-2.3	-2.7	-1.3	-0.2
Condit. Reinf. active minus inactive responses	1.1	1.2	3.3	-0.5	-0.8	1.1	-0.3	1.4	-1.8
Condit. Reinf. active-inactive response ratio	0.8	0.9	2.0	-0.0	-1.2	0.7	-0.1	1.4	-1.3
Condit. Reinf. active responses	1.5	1.8	3.4	-1.6	0.6	1.9	0.1	1.1	-1.8
Condit. Reinf. inactive responses	1.7	2.0	4.6	-2.1	1.5	1.9	0.5	0.5	-1.1
Incentive salience index mean	0.7	0.9	2.2	-0.6	-0.2	1.0	-0.6	1.1	-1.5
Condit. Reinf. lever presses	0.2	0.3	0.8	-0.4	0.4	0.5	-0.8	0.0	-0.9
Condit. Reinf. active minus inactive responses	2.1	2.6	4.1	-2.0	0.4	2.0	2.0	1.7	-0.7
Condit. Reinf. active-inactive response ratio	1.8	1.9	3.7	-1.6	0.7	1.3	1.9	1.7	0.1
Condit. Reinf. active responses	2.3	3.2	5.4	-2.3	0.8	2.3	2.3	1.2	-1.1
Condit. Reinf. inactive responses	1.2	1.5	2.9	-1.5	0.5	1.7	1.4	0.6	-1.1
Condit. Reinf. lever presses	1.0	1.3	3.2	-1.8	1.0	1.4	1.1	-0.1	-0.5
Condit. Reinf. lever reinforcers received	1.9	2.6	4.9	-2.0	0.4	2.2	1.9	1.1	-1.2
Conditioned reinforcement - actives	1.8	1.8	6.1	1.4	-2.5	-0.4	-0.9	1.2	-0.7
Conditioned reinforcement - inactives	0.2	0.3	0.8	0.5	-0.9	-0.3	-0.2	0.1	-0.7
Conditioned locomotion	1.1	1.4	5.2	0.7	-2.3	0.1	-1.0	0.7	-1.0
Patch foraging indifference point 0 sec	1.6	2.6	7.1	-2.3	2.7	0.9	1.0	-1.0	0.5
Patch foraging indifference point AUC	0.6	0.7	2.8	0.5	0.3	-0.8	0.1	-1.7	0.5
Delay disc. indifference point, 0s delay	0.4	0.4	1.6	-0.2	1.3	-0.3	0.0	0.1	0.9
Delay disc. indifference point, 16s delay	0.4	0.4	1.1	0.4	0.6	-0.4	1.0	-0.5	0.6
Delay disc. indifference point, 2s delay	1.0	1.1	2.0	1.3	0.8	-1.4	-0.5	-0.5	1.4
Delay disc. indifference point, 24s delay	0.3	0.3	0.6	0.5	0.4	-0.8	0.4	0.0	0.7
Delay disc. indifference point, 4s delay	0.5	0.5	0.8	0.7	0.6	-0.9	0.4	0.6	0.9
Delay disc. indifference point, 8s delay	0.8	0.9	1.8	1.1	0.5	-1.3	-0.1	-1.0	0.9
Indifference point function ln k	0.3	0.4	1.1	-0.9	1.1	0.5	-0.5	0.2	0.3
Indifference point function log k	0.3	0.4	1.1	-0.9	1.1	0.5	-0.5	0.2	0.3
Patch foraging total patch changes 0 sec	1.9	3.1	8.7	-2.5	2.9	1.0	1.2	-1.0	0.6
Patch foraging total patch changes 12 sec	1.2	1.5	3.4	-1.9	1.8	0.9	1.1	-0.8	0.0
Patch foraging total patch changes 18 sec	0.7	0.8	2.0	-1.4	1.1	0.8	0.7	-0.8	-0.1
Patch foraging total patch changes 24 sec	0.4	0.5	2.9	-0.1	0.2	-0.1	0.4	-1.7	-0.3
Patch foraging total patch changes 6 sec	1.2	1.8	3.6	-1.6	1.8	0.5	1.2	-1.9	0.0
Patch foraging time to switch 0 sec	0.7	1.1	3.2	0.9	-1.8	-0.1	-0.3	1.5	-0.7
Patch foraging water rate 0 sec	1.4	2.2	7.2	-1.3	2.7	0.2	0.4	-1.8	0.9
Patch foraging water rate 12 sec	1.2	1.8	3.7	-1.9	1.9	1.1	1.4	0.0	0.5
Patch foraging water rate 18 sec	1.2	1.6	4.3	-0.5	2.1	-0.4	-0.5	-1.7	1.4
Patch foraging water rate 24 sec	2.8	3.9	13.0	-1.3	3.6	-0.3	-0.4	-2.0	2.0
Patch foraging water rate 6 sec	0.9	1.3	4.0	-1.0	2.0	0.1	-0.2	-1.2	1.2
Seeking ratio, delayed vs. immediate footshock	2.0	2.3	4.7	2.2	-2.1	-0.7	-1.6	-0.4	-1.2
Distance traveled before self-admin	3.1	3.3	5.7	2.1	0.3	-2.4	-2.0	-1.4	1.8
Distance traveled after self-admin	1.7	1.9	3.6	1.9	-0.6	-1.8	-1.6	-1.1	0.6
Extensor digitorum longus weight	0.8	3.2	9.4	-3.1	2.1	1.9	1.3	0.2	0.2
Bone: elastic displacement	0.4	0.5	1.3	0.7	0.0	-1.0	-0.3	-0.1	1.1
Bone: elastic work	1.7	2.2	5.6	-0.1	2.2	-1.2	-0.6	-1.0	2.4
Bone: endosteal estimation	1.1	2.4	5.4	-2.3	1.9	1.5	1.3	1.0	0.3
Bone: endosteal perimeter	1.2	2.5	6.2	-1.9	2.5	1.1	1.7	-0.0	0.9
Epididymis fat weight	16.2	37.7	95.2	-9.8	7.9	6.4	5.2	1.2	-0.2
Delta time in closed arm before/after self-admin	0.3	0.3	0.9	-0.3	-0.0	0.3	-1.0	0.7	-0.2
Delta time in open arm before/after self-admin	3.4	3.2	5.8	-1.6	-1.4	2.1	2.4	1.0	-1.9
Diff in mean of infusions in LGA sessions	0.1	0.2	0.7	0.1	-0.3	-0.4	0.8	-0.1	0.2
Delay discount exponential model param	0.8	0.9	1.5	-0.8	-0.9	1.2	-0.5	0.6	-1.2
Extinction: sum of active levers before priming	0.3	0.3	1.0	-0.1	-0.3	0.4	1.0	0.4	-0.7
Active lever presses in extinction session 6	0.8	0.7	1.2	0.1	1.0	-1.0	0.3	-1.1	1.1
Bone: final force	3.2	5.2	16.2	-3.1	4.0	1.4	1.0	-0.2	1.5
Bone: final moment	3.4	5.5	15.4	-3.4	3.9	1.7	1.2	0.1	1.2
Food consumed during 24 hour testing period	0.4	0.5	1.4	-1.2	0.4	0.7	0.1	1.1	0.0
Glucose	2.8	4.2	10.3	-2.6	1.9	1.8	3.2	1.1	0.2
Heart weight	3.7	5.2	11.1	-3.3	3.2	1.8	2.1	1.2	0.8
Delay discount hyperbolic model param	0.9	0.9	1.7	-1.0	-1.0	1.3	-0.3	0.6	-1.3
Intermittent access intake day 1-15 change	0.1	0.1	0.5	-0.1	-0.7	0.1	0.6	-0.1	-0.1
Intermittent access intake escalation	0.1	0.1	0.2	0.2	-0.3	-0.3	-0.1	-0.5	0.4
Intermittent access intake escalation 2	0.2	0.2	0.4	-0.6	-0.5	0.5	0.5	0.1	-0.0
Intermitt. access day 1 inactive lever presses	0.2	0.2	0.3	-0.6	0.3	0.2	0.6	-0.5	-0.4
Intermitt. access day 15 inactive lever presses	1.1	1.3	3.6	0.2	1.1	-1.0	-0.0	-1.9	1.3
Intermitt. access escalation Index	0.3	0.3	0.7	-0.5	-0.2	0.7	0.1	-0.5	-0.9
Intermittent access day 1 total infusions	0.2	0.3	0.6	0.8	-0.7	-0.5	-0.4	-0.3	-0.1
Intermittent access day 15 total infusions	0.3	0.3	0.7	0.8	-0.9	-0.6	-0.4	-0.4	0.2
Intermittent access terminal intake (last 3 days)	0.1	0.2	0.3	0.5	-0.6	-0.4	-0.0	-0.4	0.2
Intermittent access total infusions	0.4	0.4	1.2	0.9	-1.1	-0.5	-0.4	-0.4	0.0
Intermittent access day 1 locomotion	1.3	1.4	3.0	1.7	-0.6	-1.3	-1.5	-1.0	0.1
Intermittent access day 15 total locomotion	0.1	0.1	0.4	0.0	-0.1	-0.0	0.6	0.2	-0.2
Intermittent access total locomotion	0.6	0.6	1.3	1.1	-0.5	-0.8	-1.1	-0.6	0.0
Intermittent access standard deviation	0.6	0.7	2.2	-0.1	-1.5	0.7	1.0	0.3	-0.5
Left kidney weight	4.2	11.8	31.7	-5.3	5.6	2.7	0.4	-0.1	1.9
Right kidney weight	4.0	11.1	31.9	-5.0	5.6	2.3	0.0	-1.2	1.9
Cocaine induced anxiety	1.3	1.5	5.1	1.4	-2.3	-0.5	-1.2	-0.6	-0.4
Post-drug Anxiety	0.4	0.4	1.1	0.6	-1.0	-0.1	-0.1	-0.7	-0.5
Baseline Anxiety	0.9	1.0	2.6	-1.0	1.2	0.7	1.6	-0.0	-0.6
Tail length	0.6	1.7	3.5	-1.9	0.0	1.3	1.8	1.2	-0.3
Length with tail	1.4	5.2	13.6	-3.7	2.3	2.4	2.2	1.4	0.0
Length without tail	2.3	4.9	12.3	-3.5	3.1	2.3	1.2	0.9	0.2
Times rat made contact with spout	1.1	1.2	3.4	-1.8	1.0	1.1	0.6	1.2	-0.1
Lifetime Intake	0.7	0.8	1.7	1.3	-1.0	-0.9	-0.7	-0.8	0.2
Liver weight, left	2.8	4.5	10.6	-3.2	2.8	2.0	2.0	-0.0	-0.3
Liver weight, right	5.5	9.0	22.1	-4.7	3.7	3.3	2.7	0.8	-0.7
Locomotor activity	0.1	0.2	0.6	-0.2	-0.8	0.3	0.1	0.4	-0.4
Locomotor testing distance	0.3	0.4	1.0	0.6	-1.0	-0.6	-0.9	-0.2	0.2
Locomotor testing rearing	0.6	0.9	1.7	0.9	-0.4	-1.1	-0.6	-1.0	1.3
Locomotion in novel chamber	1.6	2.0	2.9	0.4	1.7	-1.5	-1.5	-1.6	1.4
Locomotion in novel chamber post-restriction	2.9	3.5	4.7	1.6	1.4	-2.2	-2.0	-1.8	2.0
Fecal boli incidents, locomotor time 1	0.7	0.8	2.4	-0.7	0.2	0.9	1.5	1.0	-0.3
Change in fecal boli incidents, locomotor task	0.5	0.5	1.7	-1.3	0.2	1.0	-0.0	0.3	-0.5
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.3	-0.1	-0.5	0.4	0.3	0.3	-0.5
Bouts of movement, locomotor time 1	0.6	0.7	1.0	-1.0	-0.9	1.0	0.8	0.0	-0.9
Total resting periods, locomotor time 1	0.4	0.4	0.8	-0.9	-0.7	0.8	0.5	-0.0	-0.5
Rest time, locomotor task time 1	0.5	0.6	1.6	-0.5	0.3	-0.1	-1.3	-1.0	0.7
Distance moved, locomotor task time 1	0.3	0.4	1.1	1.1	0.3	-0.9	0.1	-0.1	0.3
Vertical activity count, locomotor time 1	0.5	0.5	1.6	1.2	0.3	-1.1	-0.4	-0.2	0.3
Time >=10cm from walls, locomotor time 2	0.2	0.2	0.9	-0.3	0.9	0.2	-0.2	-0.2	0.1
Bouts of movement, locomotor time 2	0.2	0.3	0.8	0.4	-0.9	-0.2	-0.3	0.7	0.3
Total resting periods, locomotor time 2	0.3	0.3	1.0	0.6	-1.0	-0.4	-0.4	0.5	0.3
Rest time, locomotor task time 2	0.2	0.2	0.9	0.3	-0.9	-0.4	-0.4	-0.4	0.0
Distance moved, locomotor task time 2	0.4	0.4	1.6	0.4	0.8	-0.4	-0.4	-1.2	0.2
Vertical activity count, locomotor time 2	0.1	0.1	0.3	0.3	0.5	-0.0	-0.3	-0.4	-0.3
Light reinforcement 1	0.5	0.8	2.4	0.5	0.3	-0.7	-1.6	-1.2	0.5
Light reinforcement 2	0.1	0.2	0.4	0.0	-0.6	0.5	-0.1	0.6	-0.4
Bone: marrow area	1.2	2.5	5.7	-2.4	2.0	1.6	1.3	1.0	0.3
Bone: maximum diameter	2.8	5.1	12.1	-3.5	2.4	2.4	2.6	0.3	-0.3
Bone: maximum force	3.0	5.2	15.3	-3.3	3.9	1.7	0.8	-0.0	1.1
Bone: maximum moment	3.1	5.4	14.0	-3.6	3.7	1.9	1.0	0.3	0.8
Mean time between licks in bursts	2.2	3.1	5.5	-1.4	-1.6	1.9	1.2	1.9	-2.3
Mean num. licks in bursts	0.8	0.9	2.1	-0.3	1.5	-0.5	-1.2	-0.7	1.1
Cd content in liver	0.6	0.7	1.8	0.0	-1.3	0.5	-0.7	0.2	-1.2
Co content in liver	0.5	0.6	1.2	-0.1	1.0	-0.2	-1.1	-1.0	0.4
Cu content in liver	0.1	0.1	0.2	-0.2	0.3	0.1	0.2	-0.2	0.4
Fe content in liver	0.0	0.0	0.1	-0.0	0.1	0.2	0.2	0.0	-0.3
K content in liver	0.2	0.2	0.4	0.3	0.0	-0.3	0.1	-0.6	0.6
Mg content in liver	0.8	0.8	1.7	0.9	0.3	-1.0	-0.0	-1.1	1.3
Mn content in liver	0.2	0.3	0.5	-0.1	0.7	-0.3	-0.6	-0.4	0.6
Na content in liver	0.7	0.7	1.6	-0.3	0.9	-0.1	1.2	0.5	1.3
Rb content in liver	0.6	0.7	2.2	1.5	-0.5	-1.1	-0.3	-0.6	0.5
Se content in liver	0.2	0.2	0.7	0.9	-0.3	-0.4	-0.0	-0.4	0.3
Sr content in liver	5.1	4.6	8.5	2.9	-0.7	-2.8	-2.4	-1.7	1.6
Zn content in liver	2.2	2.5	4.6	1.2	1.1	-1.5	-1.6	-1.6	2.2
Bone: minimum diameter	2.7	5.0	11.5	-3.4	2.8	2.2	2.1	1.1	0.4
Time in familiar zone, hab. session 1	1.0	0.9	2.7	-0.7	1.6	0.1	0.9	-0.8	1.0
Time in novel zone, hab. session 1	2.3	2.3	6.6	0.7	-2.6	0.4	0.0	1.7	-1.8
Total zone transitions, hab. session 1	1.3	1.9	5.5	1.0	1.1	-1.3	-0.8	-2.3	1.0
Total locomotion distance, hab. session 1	0.2	0.3	0.7	0.1	-0.4	0.2	0.3	-0.8	-0.8
Locomotion velocity, hab. session 1	0.2	0.2	1.0	-0.0	-0.2	0.2	0.0	-1.0	-0.6
Time in familiar zone, hab. session 2	2.3	2.3	4.0	-1.2	-1.3	1.6	1.5	1.4	-2.0
Time in novel zone, hab. session 2	0.7	0.7	2.0	0.6	1.0	-0.8	-0.6	-0.3	1.4
Total zone transitions, hab. session 2	0.6	0.8	1.8	0.5	1.0	-0.8	-0.5	-1.3	0.8
Total locomotion distance, hab. session 2	0.2	0.3	0.6	-0.8	0.7	0.6	0.4	0.1	-0.2
Locomotion velocity, hab. session 2	0.2	0.3	0.8	-0.6	0.9	0.3	0.3	-0.3	0.1
Novel to familiar place preference ratio	1.8	1.8	3.9	-1.0	-0.7	1.5	0.9	2.0	-1.6
Novelty place preference	1.6	1.7	4.3	-0.8	-0.8	1.3	0.8	2.1	-1.4
Time in novel zone, NPP test	3.2	3.3	7.0	-1.4	-0.8	2.0	1.5	2.6	-1.9
Total zone transitions, NPP test	0.5	0.7	1.7	-0.4	1.3	-0.1	-0.8	-1.3	0.5
Total locomotion distance, NPP test	0.2	0.3	0.7	-0.4	0.9	0.3	-0.5	-0.8	-0.1
Locomotion velocity, NPP test	0.7	1.0	2.4	0.2	1.0	-0.6	-1.5	-1.5	0.5
Intraocular pressure	1.5	2.1	4.0	-1.3	-0.4	1.3	1.4	2.0	-1.8
Delta distance traveled before/after self-admin	0.3	0.3	1.1	0.2	-0.9	0.3	0.0	-0.2	-1.0
Delta ambulatory time before/after self-admin	0.3	0.4	1.4	0.1	-0.9	0.3	-0.0	-0.0	-1.2
Parametrial fat weight	10.0	19.4	51.0	-7.1	5.3	4.5	4.0	0.5	-0.4
Pavlov. Cond. lever latency	0.5	0.6	2.6	0.8	-1.6	-0.2	0.2	-0.4	-0.4
Pavlov. Cond. magazine entry latency	0.6	0.8	1.9	-1.4	1.0	1.0	0.5	0.8	-0.3
Pavlov. Cond. change in total contacts	3.1	3.4	6.0	-2.5	1.2	2.0	1.6	2.4	-0.8
Pavlov. Cond. index score	0.9	1.1	2.7	-1.6	1.2	1.2	0.6	0.9	-0.3
Pavlov. Cond. latency score	0.8	1.0	2.2	-1.5	1.1	1.0	0.6	1.1	-0.2
Pavlov. Cond. lever contacts	0.7	0.8	1.8	-1.3	1.3	0.8	0.7	0.6	0.0
Pavlov. Cond. magazine entry number	1.0	1.2	2.7	1.7	-0.8	-1.4	-0.7	-1.1	0.6
Pavlov. Cond. intertrial magazine entries	1.0	1.3	3.5	-1.9	1.6	1.2	-0.1	0.0	-0.3
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.4	3.2	-1.8	1.2	1.3	0.8	1.1	-0.4
Pavlov. Cond. response bias	0.6	0.7	1.7	-1.3	1.3	0.8	0.4	0.6	-0.0
Pavlov. Cond. lever latency	1.4	1.9	4.0	2.0	-0.2	-1.9	-1.3	-0.4	1.3
Pavlov. Cond. magazine entry latency	0.5	0.6	1.3	-0.2	-0.3	0.6	1.0	0.9	-1.2
Pavlov. Cond. change in total contacts	0.6	0.8	1.4	-1.0	-0.2	1.2	1.1	0.2	-1.0
Pavlov. Cond. index score	0.6	0.8	1.5	-0.9	0.1	1.1	0.9	0.1	-1.2
Pavlov. Cond. latency score	0.5	0.6	1.2	-0.9	0.1	1.1	0.8	-0.1	-1.1
Pavlov. Cond. lever contacts	0.8	1.1	2.2	-1.5	0.2	1.4	1.1	0.2	-1.0
Pavlov. Cond. magazine entry number	0.1	0.1	0.4	-0.0	-0.3	-0.2	-0.5	-0.0	0.6
Pavlov. Cond. intertrial magazine entries	0.9	1.1	2.9	-1.5	1.7	0.4	-0.1	-0.4	1.0
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	1.1	-0.6	0.1	0.9	0.8	0.0	-1.0
Pavlov. Cond. response bias	1.5	2.0	3.3	-1.6	-0.3	1.8	1.5	1.0	-1.7
Time in closed arm before self-admin	0.4	0.5	1.5	0.8	0.1	-0.7	0.4	-1.2	0.5
Time in closed arm after self-admin	0.4	0.5	0.8	0.8	-0.2	-0.8	-0.9	-0.3	0.7
Time in open arm before self-admin	0.4	0.4	0.7	0.8	-0.8	-0.3	-0.6	0.8	0.1
Time in open arm after self-admin	1.8	2.0	4.1	-0.6	-1.4	1.4	2.0	1.3	-1.4
Bone: periosteal estimation	3.2	6.6	15.4	-3.9	3.8	2.3	1.8	0.4	0.7
Bone: periosteal perimeter	3.4	5.6	13.8	-3.2	3.7	1.8	2.2	-0.2	1.2
Bone: post-yield work	1.4	1.9	4.3	-2.1	1.1	1.9	0.7	0.7	-1.0
Progressive ratio test 1 active lever presses	0.9	0.9	1.9	1.4	-0.8	-1.1	-1.0	-0.8	0.4
Progressive ratio test 1 breakpoint	1.0	1.1	2.2	1.5	-0.8	-1.3	-0.9	-1.0	0.5
Progressive ratio test 1 inactive lever presses	0.4	0.5	0.6	0.8	-0.8	-0.5	-0.7	-0.8	-0.5
Progressive ratio test 2 active lever presses	0.4	0.4	1.0	0.3	0.6	-0.7	-0.1	-0.7	1.0
Progressive ratio test 2 breakpoint	0.5	0.5	1.0	0.3	0.6	-0.8	-0.1	-1.0	1.0
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.2	-0.4	-0.3	0.4	0.1	-0.4	-0.4
Incentive Sensitization - Responses	0.4	0.4	1.2	-0.6	1.1	-0.1	0.6	-0.3	0.7
Incentive Sensitization - Breakpoint	0.3	0.3	0.9	-0.7	0.9	0.1	0.7	-0.2	0.5
Sum of active levers in priming session hrs 5-6	0.2	0.2	1.0	-0.0	-1.0	-0.0	0.2	0.2	-0.4
Progressive ratio	2.0	2.3	5.4	2.3	-1.4	-1.7	-1.3	-1.2	0.3
Food seeking constrained by brief footshock	2.3	2.9	7.9	2.8	-2.4	-1.5	-0.7	-0.9	-0.6
Seeking ratio, punishment vs. effort	0.0	0.0	0.2	-0.2	0.1	0.4	0.1	0.1	-0.3
Retroperitoneal fat weight	18.0	59.1	139.6	-11.8	11.0	7.3	6.2	0.9	0.5
Reaction time number correct	0.3	0.4	1.0	-0.7	0.5	0.6	1.0	-0.1	0.1
Reaction time mean minus median	0.9	1.3	2.5	1.2	0.7	-1.3	-0.3	-1.6	1.2
Reaction time mean minus median AUC	2.5	3.2	6.1	1.8	1.0	-2.2	-0.8	-1.9	2.5
Reaction time num false alarms	0.8	1.1	2.0	-1.4	1.4	0.9	-0.2	1.3	-0.1
Reaction time num false alarms AUC	0.8	1.2	2.8	-1.4	1.7	0.8	-0.1	1.2	0.2
Reaction time trials correct on left	0.3	0.4	1.0	-0.7	0.5	0.6	1.0	-0.1	0.1
Reaction time trials on left	0.3	0.4	1.0	-0.7	0.4	0.6	1.0	-0.1	0.1
Reaction time mean	1.9	2.7	6.5	2.6	-0.6	-2.2	-0.7	-1.8	0.9
Reaction time mean AUC	2.6	3.5	8.4	2.9	-0.6	-2.5	-0.9	-1.9	1.2
Median of all reaction times	2.2	3.0	7.5	2.7	-0.6	-2.4	-0.8	-1.8	0.9
Reaction time omissions	0.1	0.2	0.5	0.4	-0.6	-0.0	0.3	0.1	-0.7
Reaction time false alarm rate	0.7	0.9	2.0	-1.2	1.3	0.7	-0.4	1.4	-0.1
Reaction time premature initiation rate	1.4	1.9	7.5	0.7	1.2	-1.1	-0.8	-2.7	0.5
Reaction time premature initiations	1.2	1.6	6.7	0.2	1.4	-0.7	-0.2	-2.6	0.7
Std. dev. reaction times	0.5	0.7	1.2	1.0	0.6	-1.1	-0.1	-1.0	0.9
Reaction time trials completed	0.3	0.4	1.0	-0.7	0.4	0.6	1.0	-0.1	0.1
Reaction time trials AUC	0.4	0.6	1.2	-1.1	0.6	0.8	1.1	0.0	0.1
Run reversals in cocaine runway, females	0.5	0.5	1.7	0.8	-0.4	-0.5	0.4	-1.3	-0.3
Run reversals in cocaine runway, males	2.0	2.0	3.1	1.5	-0.1	-1.6	-1.8	-1.6	1.2
Latency to leave start box in cocaine runway	0.9	1.0	2.8	0.5	-1.7	-0.0	1.4	0.9	-0.2
Latency to leave start box in cocaine runway, F	0.5	0.5	1.4	-0.3	-0.9	0.3	1.2	0.9	-0.2
Latency to leave start box in cocaine runway, M	0.4	0.4	1.1	0.9	-1.0	-0.5	0.5	0.1	0.4
Std. dev. time between licks in bursts	0.8	1.0	2.6	-0.2	-1.3	0.9	-0.0	0.8	-1.6
Total sessions with >9 infusions	1.5	1.6	3.0	1.5	0.0	-1.5	-1.7	-1.1	1.0
Short access day 1 total inactive lever presses	0.6	0.7	1.7	0.2	-1.2	0.2	-0.7	-0.5	-1.3
Short access day 10 total inactive lever presses	0.7	0.8	2.2	-1.0	1.5	0.1	-0.7	-0.8	0.4
Short access day 1 total infusions	0.9	0.9	1.9	1.3	-0.4	-1.0	-1.4	-0.9	0.2
Short access day 10 total infusions	0.8	0.9	2.2	1.5	-1.4	-0.9	-0.6	-0.4	0.2
Short access total infusions	1.5	1.6	3.3	1.8	-0.8	-1.5	-1.3	-1.3	0.6
Short access day 1 locomotion	0.6	0.7	1.5	1.2	-0.1	-1.1	-0.9	-0.7	0.3
Short access day 10 total locomotion	0.3	0.3	0.7	0.7	-0.2	-0.4	-0.5	-0.9	0.1
Short access total locomotion	3.3	3.5	5.2	2.3	0.3	-2.2	-2.0	-2.1	1.5
One hour access (0.3 mA shock)	0.5	0.6	2.8	0.6	-1.7	-0.2	0.3	-0.0	-0.7
Compulsive drug intake	0.3	0.3	0.8	-0.7	-0.2	0.7	0.1	0.4	-0.9
One hour access (shock baseline)	0.6	0.7	2.0	1.0	-1.4	-0.7	-0.3	-0.7	-0.0
Social response proportion	0.8	0.8	2.0	-1.4	0.8	1.2	-0.1	-0.1	-0.9
Social responses	1.3	1.7	3.6	-1.9	1.2	1.4	1.4	-0.9	-0.6
Social time	0.1	0.1	0.4	-0.2	0.1	0.1	0.7	-0.0	-0.0
Soleus weight	1.3	3.9	14.5	-1.6	3.8	-0.1	-0.1	-1.4	2.2
Bone: stiffness	1.4	2.2	6.9	-2.0	2.6	1.1	0.3	-0.5	0.8
Tibialis anterior weight	0.1	0.5	1.4	-1.2	0.4	0.9	0.6	-0.1	-0.2
Time to tail flick, vehicle, before self-admin	0.9	0.9	2.2	-1.3	0.0	1.5	0.8	-0.0	-1.0
Time to tail flick, vehicle, after self-admin	0.2	0.3	0.4	-0.6	0.6	0.2	0.6	-0.5	0.3
Time to tail flick, test, before self-admin	1.7	1.6	2.9	1.6	-0.2	-1.7	-1.6	-0.9	1.0
Time to tail flick, test, after self-admin	0.6	0.6	1.0	-0.7	-0.1	1.0	1.0	-0.4	-0.9
Delta time to tail flick, vehicle, before/after SA	0.9	0.9	2.2	0.0	1.3	-0.9	0.7	-0.6	1.5
Delta time to tail flick, test, before/after SA	3.6	3.2	6.2	-2.4	0.3	2.5	2.1	0.5	-1.5
Tibia length	0.2	0.7	1.7	-1.2	1.3	0.7	0.4	0.4	0.0
Ambulatory time before self-admin	2.1	2.1	3.9	1.7	0.2	-2.0	-1.7	-0.9	1.6
Ambulatory time after self-admin	1.9	2.1	4.6	2.1	-1.0	-1.9	-1.6	-0.9	0.3
Bone: tissue strength	0.5	0.5	1.4	0.2	-1.2	0.1	0.5	0.9	-0.7
Total heroin consumption	1.0	1.1	2.6	-1.2	1.6	-0.0	1.2	-0.7	0.9
Bone: trabecular number	1.6	2.5	5.4	-2.3	1.2	1.9	1.2	1.4	-0.8
Bone: trabecular spacing	1.4	1.9	7.0	1.4	-2.6	-0.2	-0.2	0.8	-1.2
Bone: trabecular thickness	4.0	4.7	11.2	-3.3	3.3	1.7	1.7	-0.0	0.6
Bone: trabecular tissue density	0.6	0.8	2.1	1.0	-1.4	-0.3	-1.1	-0.3	-0.7
Water consumed over 24 hours	0.2	0.2	0.6	-0.4	0.3	-0.2	-0.5	0.6	0.8
Number of responses in last shaping day	0.4	0.5	0.9	1.0	-0.5	-0.6	-0.6	-0.9	-0.0