Nanos1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Nanos1	0.11	0.06	2.7e-08	0.06	0.09	0.07	0.08	1.1e-06	1.3e-08	7.2e-07	5.3e-08
2	PL	gene expression	Nanos1	0.11	0.06	1.9e-06	0.06	0.06	0.06	0.06	3.8e-07	1.9e-07	7.2e-07	4.9e-07
3	Liver	gene expression	Nanos1	0.08	0.04	5.4e-08	0.06	0.05	0.02	0.04	5.6e-07	2.8e-06	8.8e-04	1.7e-05
4	pVTA	gene expression	Nanos1	0.12	0.08	7.0e-04	0.03	0.04	0.05	0.04	1.0e-03	2.2e-04	1.4e-04	7.3e-04
5	BLA	gene expression	Nanos1	0.14	0.09	2.4e-04	0.05	0.04	0.03	0.04	1.4e-03	2.2e-03	1.0e-02	2.9e-03
6	NAcc	gene expression	Nanos1	0.04	0.02	4.1e-05	0.01	0.02	0.02	0.02	2.5e-03	2.1e-04	7.5e-04	9.7e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	4.0	7.3	13.6	-3.4	-3.7	1.5	2.4	2.9	-1.5
Area under the delay curve	0.6	0.9	1.9	0.9	1.4	0.8	-0.2	-1.0	0.9
BMI with tail	16.2	56.5	98.5	-9.4	-8.0	9.9	7.3	5.8	0.4
BMI without tail	6.5	34.7	57.5	-7.5	-6.2	7.6	5.8	4.7	0.4
Body weight	15.3	66.9	113.9	-10.7	-9.1	9.1	8.2	7.3	-0.7
Weight adjusted by age	1.0	2.9	5.3	-2.3	-1.7	2.1	1.7	1.0	0.6
Bone surface	2.9	5.8	9.7	-2.8	-3.1	1.7	2.7	2.4	-1.1
Bone volume	3.5	7.1	11.3	-3.4	-3.4	2.5	2.6	2.5	-0.6
Breakpoint value in progressive ratio session	0.3	0.5	1.5	-1.2	-0.1	0.5	1.1	0.3	0.1
Number of licking bursts	0.3	0.9	1.4	-0.8	-0.6	-0.7	1.2	1.0	-1.2
Context. condit. distance diff. score	0.3	0.4	0.8	-0.3	-0.9	0.3	0.7	0.6	-0.5
Locomotion velocity, session 1	0.4	0.5	1.9	0.7	0.3	-1.4	0.2	0.1	-0.5
Locomotion distance, session 1	1.2	1.5	4.2	2.0	1.2	-0.4	-1.0	-1.4	0.6
Locomotion velocity, session 2	0.7	0.8	1.5	1.2	0.8	-0.6	-1.1	-0.9	0.5
Locomotion distance, session 2	0.4	0.6	2.3	0.0	-0.4	1.5	-0.1	-0.4	1.0
Locomotion velocity, session 3	1.3	1.5	2.8	1.7	1.0	-1.3	-1.6	-1.0	-0.0
Locomotion distance, session 3	0.5	0.6	1.0	1.0	0.5	-0.9	-1.0	-0.6	-0.0
Stereotopy head waving bouts, day 3	1.0	1.1	1.8	1.3	1.3	-0.0	-1.1	-1.2	0.9
Stereotopy head waving duration, day 3	1.5	1.8	3.8	1.6	1.9	-0.1	-1.0	-1.5	1.1
Locomotion velocity, session 7	0.1	0.1	0.1	0.1	-0.3	0.3	0.3	0.1	-0.2
Locomotion distance, session 7	0.6	0.7	2.0	-0.9	-1.4	1.0	0.5	0.6	-0.1
Stereotopy head waving bouts, day 7	0.9	1.0	3.3	1.3	1.8	-0.0	0.2	-0.9	0.5
Stereotopy head waving duration, day 7	0.8	1.0	3.4	1.3	1.8	-0.8	0.3	-0.6	-0.1
Locomotion velocity, session 8	0.7	0.8	2.5	0.2	-0.5	-1.6	0.2	0.6	-1.3
Locomotion distance, session 8	0.4	0.5	1.9	-0.2	-1.4	-0.1	0.5	0.7	-0.7
Degree of sensitization distance	1.8	2.0	3.6	-1.9	-1.7	1.3	1.4	1.2	-0.2
Degree of sensitization stereotypy	0.3	0.4	1.2	0.5	1.1	0.0	0.8	-0.2	-0.1
Conditioned locomotion	0.1	0.1	0.4	0.3	0.6	-0.5	-0.2	-0.3	-0.0
Cocaine response after cond. corrected	1.5	2.2	5.7	1.7	0.7	-0.2	-2.4	-1.7	1.2
Cocaine response after cond. not corrected	1.5	2.1	5.9	1.6	0.8	-1.4	-2.4	-1.2	0.4
Cocaine response before conditioning	1.7	2.0	4.9	-0.9	-0.4	-2.2	0.7	1.4	-1.9
Saline control response	1.3	1.7	2.9	1.3	1.7	-0.7	-1.6	-1.4	1.0
Bone: connectivity density	1.3	2.1	4.5	-1.4	-2.1	0.5	1.4	1.6	-1.2
Bone: cortical apparent density	3.9	6.2	11.7	3.1	2.2	-2.5	-3.4	-2.2	0.3
Bone: cortical area	5.9	9.6	18.0	-4.2	-3.3	3.5	3.1	2.6	-0.2
Bone: cortical porosity	0.4	0.5	0.9	-1.0	-0.9	0.3	0.5	0.7	-0.4
Bone: cortical porosity	1.3	1.4	2.7	-1.6	-1.3	0.9	1.2	1.2	-0.5
Bone: cortical thickness	2.9	4.9	9.9	-3.1	-2.2	3.2	1.6	1.5	0.5
Bone: cortical thickness	2.2	2.7	10.7	-1.0	-0.1	3.3	-0.0	-0.5	2.0
Bone: cortical tissue density	4.0	6.4	11.7	3.1	2.2	-2.7	-3.4	-2.2	0.2
Condit. Reinf. active minus inactive responses	1.1	1.2	2.7	-0.5	-1.6	-0.8	0.6	1.1	-1.4
Condit. Reinf. active-inactive response ratio	0.6	0.6	1.4	0.1	-0.6	-1.2	0.5	0.6	-1.1
Condit. Reinf. active responses	2.5	3.2	8.6	-1.8	-2.9	0.6	1.2	1.9	-1.4
Condit. Reinf. inactive responses	3.1	4.0	9.0	-2.6	-3.0	1.5	1.2	1.9	-0.9
Incentive salience index mean	0.9	1.1	3.6	-0.6	-1.9	-0.2	0.6	1.1	-1.1
Condit. Reinf. lever presses	0.3	0.5	2.0	-0.3	-1.4	0.4	0.0	0.5	-0.5
Condit. Reinf. active minus inactive responses	1.5	2.3	3.8	-1.9	-1.4	0.3	1.9	1.8	-1.1
Condit. Reinf. active-inactive response ratio	0.8	1.3	3.3	-1.4	-0.7	0.7	1.8	1.2	-0.4
Condit. Reinf. active responses	2.5	3.6	5.4	-2.3	-2.0	0.8	2.2	2.2	-1.3
Condit. Reinf. inactive responses	1.4	2.1	3.0	-1.7	-1.7	0.5	1.4	1.7	-1.1
Condit. Reinf. lever presses	1.2	1.7	3.3	-1.8	-1.5	1.1	1.2	1.3	-0.5
Condit. Reinf. lever reinforcers received	2.1	2.9	4.4	-2.1	-1.9	0.3	1.8	2.1	-1.5
Conditioned reinforcement - actives	0.3	1.1	2.4	1.4	1.2	-1.6	-0.5	-0.7	0.2
Conditioned reinforcement - inactives	0.2	0.6	1.6	0.7	0.7	-1.3	-0.9	-0.4	-0.5
Conditioned locomotion	0.9	1.3	2.8	1.7	1.2	-1.6	-0.8	-0.8	0.1
Patch foraging indifference point 0 sec	1.0	2.9	8.3	-2.1	-1.4	2.9	1.4	0.7	0.7
Patch foraging indifference point AUC	0.2	0.5	1.0	0.5	1.0	-0.0	-0.9	-0.9	0.4
Delay disc. indifference point, 0s delay	0.3	0.4	1.2	0.1	0.2	1.1	0.2	-0.4	0.9
Delay disc. indifference point, 16s delay	0.3	0.5	1.1	0.7	1.1	0.5	0.9	-0.3	0.3
Delay disc. indifference point, 2s delay	1.4	1.5	2.4	1.5	1.4	0.7	-0.8	-1.5	1.3
Delay disc. indifference point, 24s delay	0.4	0.7	1.8	0.7	1.3	0.5	-0.4	-0.8	0.8
Delay disc. indifference point, 4s delay	0.6	0.6	1.4	0.8	1.2	0.6	-0.1	-0.8	0.7
Delay disc. indifference point, 8s delay	0.8	1.3	2.6	1.2	1.6	0.4	-0.9	-1.3	0.9
Indifference point function ln k	0.2	0.7	1.4	-0.9	-1.2	1.0	0.5	0.8	0.1
Indifference point function log k	0.2	0.7	1.4	-0.9	-1.2	1.0	0.5	0.8	0.1
Patch foraging total patch changes 0 sec	1.2	3.6	10.2	-2.3	-1.5	3.2	1.5	0.8	0.8
Patch foraging total patch changes 12 sec	1.1	1.5	3.8	-1.6	-1.0	2.0	0.9	0.5	0.4
Patch foraging total patch changes 18 sec	0.4	0.9	2.3	-1.5	-1.0	1.1	0.6	0.6	0.0
Patch foraging total patch changes 24 sec	0.1	0.4	1.2	-0.1	0.5	0.5	-1.1	-0.6	0.4
Patch foraging total patch changes 6 sec	0.7	1.2	4.0	-1.6	-0.5	2.0	-0.0	-0.0	0.7
Patch foraging time to switch 0 sec	0.2	0.8	3.1	0.8	0.4	-1.8	-0.5	-0.1	-0.6
Patch foraging water rate 0 sec	0.5	1.8	7.1	-1.3	-0.9	2.7	0.7	0.3	0.9
Patch foraging water rate 12 sec	0.4	1.7	3.3	-1.7	-1.1	1.8	1.3	1.1	0.2
Patch foraging water rate 18 sec	0.5	1.2	4.7	-0.4	-0.2	2.2	0.1	-0.3	1.4
Patch foraging water rate 24 sec	2.0	2.9	12.5	-0.9	-0.6	3.5	-0.0	-0.3	1.9
Patch foraging water rate 6 sec	0.8	1.1	3.8	-1.2	-0.7	1.9	0.1	0.2	1.0
Seeking ratio, delayed vs. immediate footshock	1.6	2.3	4.7	1.9	0.5	-2.2	-1.9	-0.8	-1.0
Distance traveled before self-admin	2.0	4.4	6.7	2.6	2.2	-0.2	-2.3	-2.5	1.9
Distance traveled after self-admin	2.6	4.6	6.8	2.6	2.3	-0.9	-2.6	-2.5	1.3
Extensor digitorum longus weight	1.0	3.9	7.9	-2.8	-2.1	2.0	2.0	1.7	-0.1
Bone: elastic displacement	0.8	1.0	1.9	0.7	1.4	0.1	-1.0	-1.0	1.1
Bone: elastic work	1.6	2.1	5.2	0.2	0.8	2.3	-0.6	-1.2	2.3
Bone: endosteal estimation	1.4	3.4	5.7	-2.2	-2.1	1.6	2.4	1.7	-0.4
Bone: endosteal perimeter	1.2	3.0	6.0	-2.0	-1.3	2.2	2.5	1.3	0.2
Epididymis fat weight	12.1	60.9	109.4	-10.5	-8.6	7.9	8.0	7.3	-1.7
Delta time in closed arm before/after self-admin	0.1	0.1	0.3	0.0	-0.5	0.4	-0.4	-0.1	0.4
Delta time in open arm before/after self-admin	3.5	4.1	5.9	-2.2	-1.5	-1.1	2.4	2.4	-2.1
Diff in mean of infusions in LGA sessions	0.2	0.3	0.8	0.0	0.9	0.3	0.2	-0.7	0.6
Delay discount exponential model param	0.9	1.2	2.5	-1.1	-1.6	-0.8	0.4	1.2	-1.1
Extinction: sum of active levers before priming	0.1	0.2	0.4	-0.6	-0.3	0.4	0.6	0.4	-0.3
Active lever presses in extinction session 6	0.9	0.9	1.9	-0.2	0.8	1.3	-0.1	-1.1	1.4
Bone: final force	4.3	7.0	14.1	-3.3	-2.7	3.8	2.5	1.8	0.6
Bone: final moment	4.8	7.7	13.0	-3.6	-3.0	3.6	2.7	2.1	0.4
Food consumed during 24 hour testing period	0.2	0.4	0.8	-0.9	-0.8	0.3	0.5	0.6	-0.0
Glucose	2.6	4.0	8.7	-2.7	-1.2	1.9	3.0	1.8	-0.1
Heart weight	8.8	14.2	25.0	-5.0	-4.0	3.4	4.4	3.5	-0.7
Delay discount hyperbolic model param	1.0	1.3	2.8	-1.2	-1.7	-0.9	0.4	1.3	-1.1
Intermittent access intake day 1-15 change	0.2	0.9	1.9	1.1	1.4	-0.6	-0.5	-1.0	0.8
Intermittent access intake escalation	0.1	0.4	0.9	0.6	1.0	-0.7	0.0	-0.5	0.4
Intermittent access intake escalation 2	0.1	0.1	0.3	-0.2	0.3	-0.5	0.6	0.0	0.3
Intermitt. access day 1 inactive lever presses	0.1	0.7	2.1	-1.4	-0.8	-0.0	0.5	1.0	-0.8
Intermitt. access day 15 inactive lever presses	0.1	0.3	0.6	-0.2	0.7	0.6	-0.1	-0.4	0.8
Intermitt. access escalation Index	0.1	0.5	0.8	-0.5	-0.7	-0.6	0.1	0.9	-0.9
Intermittent access day 1 total infusions	0.2	0.5	1.0	0.8	0.8	-0.4	-1.0	-0.8	0.3
Intermittent access day 15 total infusions	0.5	1.2	2.4	1.2	1.6	-0.9	-0.9	-1.1	0.7
Intermittent access terminal intake (last 3 days)	0.5	0.8	1.9	1.0	1.4	-0.5	-0.8	-1.0	0.6
Intermittent access total infusions	0.6	0.7	1.2	1.0	1.0	-0.8	-1.1	-0.8	0.2
Intermittent access day 1 locomotion	1.1	2.1	3.4	1.9	1.5	0.0	-1.8	-1.6	0.9
Intermittent access day 15 total locomotion	0.3	1.1	2.2	1.1	1.5	-0.3	-1.0	-1.3	0.5
Intermittent access total locomotion	1.3	1.6	2.5	1.6	1.2	-0.2	-1.6	-1.6	0.8
Intermittent access standard deviation	0.1	0.6	2.2	0.7	1.5	-0.4	-0.1	-0.7	0.6
Left kidney weight	2.9	23.1	40.1	-6.3	-5.3	6.3	4.1	3.7	0.9
Right kidney weight	3.9	27.1	52.5	-6.8	-5.8	7.2	3.8	3.6	1.3
Cocaine induced anxiety	0.6	1.5	3.1	1.8	1.4	-1.4	-1.1	-0.9	0.5
Post-drug Anxiety	0.5	0.5	1.2	-0.5	-0.6	-0.4	1.1	0.9	-0.7
Baseline Anxiety	2.0	3.3	5.4	-2.2	-1.9	1.1	2.3	1.7	-1.3
Tail length	0.2	1.3	2.4	-1.6	-0.8	-0.8	1.3	1.4	-0.9
Length with tail	1.7	7.6	14.4	-3.8	-3.0	1.3	3.1	3.1	-1.2
Length without tail	2.3	12.1	20.7	-4.6	-3.9	2.2	3.9	3.7	-1.5
Times rat made contact with spout	1.2	1.4	2.2	-1.5	-1.4	1.0	1.4	1.1	-0.2
Lifetime Intake	0.7	0.8	1.4	1.1	1.0	-0.7	-1.2	-0.9	0.3
Liver weight, left	6.1	10.6	18.5	-4.3	-3.5	4.3	2.8	2.6	0.1
Liver weight, right	4.6	8.1	13.8	-3.4	-3.7	3.6	2.2	2.3	-0.1
Locomotor activity	0.1	0.2	0.8	-0.0	0.0	-0.9	-0.2	0.3	-0.3
Locomotor testing distance	0.3	0.7	1.5	0.8	0.6	-1.1	-1.2	-0.6	0.3
Locomotor testing rearing	0.4	1.6	3.1	1.0	1.8	-0.2	-1.5	-1.3	1.3
Locomotion in novel chamber	0.7	0.9	1.7	0.2	-0.1	1.3	-1.0	-1.0	1.2
Locomotion in novel chamber post-restriction	0.9	2.8	4.5	1.6	1.4	1.3	-1.3	-2.1	2.1
Fecal boli incidents, locomotor time 1	0.3	0.8	3.5	-0.4	-0.3	0.5	1.9	0.7	-0.4
Change in fecal boli incidents, locomotor task	0.4	0.4	1.2	-1.1	-1.0	0.3	-0.1	0.6	-0.1
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.2	-0.2	-0.3	-0.3	0.5	0.4	-0.5
Bouts of movement, locomotor time 1	0.4	0.5	1.0	-1.0	-0.4	-0.7	0.4	0.9	-0.7
Total resting periods, locomotor time 1	0.3	0.3	0.8	-0.9	-0.4	-0.6	0.3	0.7	-0.4
Rest time, locomotor task time 1	0.1	0.2	0.7	-0.6	-0.3	0.4	-0.2	-0.1	0.8
Distance moved, locomotor task time 1	0.2	0.6	1.1	1.1	1.0	0.1	-0.5	-0.9	0.4
Vertical activity count, locomotor time 1	0.1	0.7	1.5	1.2	0.9	0.3	-0.9	-1.0	0.4
Time >=10cm from walls, locomotor time 2	0.1	0.3	1.0	-0.4	-0.7	1.0	-0.0	0.0	0.3
Bouts of movement, locomotor time 2	0.1	0.2	0.7	0.3	0.6	-0.8	-0.4	-0.2	0.1
Total resting periods, locomotor time 2	0.1	0.4	0.9	0.5	0.8	-0.9	-0.6	-0.3	0.2
Rest time, locomotor task time 2	0.1	0.2	0.6	0.3	0.7	-0.7	-0.4	-0.3	0.2
Distance moved, locomotor task time 2	0.2	0.2	0.3	0.3	0.0	0.5	-0.6	-0.6	0.5
Vertical activity count, locomotor time 2	0.1	0.1	0.3	0.2	-0.3	0.5	-0.5	-0.3	0.1
Light reinforcement 1	0.1	0.7	2.0	0.5	0.1	0.4	-1.4	-0.9	0.8
Light reinforcement 2	0.1	0.2	0.5	0.2	-0.2	-0.7	0.3	0.4	-0.4
Bone: marrow area	1.5	3.7	6.0	-2.3	-2.1	1.8	2.4	1.8	-0.3
Bone: maximum diameter	3.6	7.3	12.9	-3.6	-2.7	2.1	3.3	2.7	-0.9
Bone: maximum force	3.6	7.1	11.6	-3.3	-3.1	3.4	2.6	2.0	0.3
Bone: maximum moment	4.1	7.7	12.4	-3.5	-3.3	3.2	2.8	2.3	0.0
Mean time between licks in bursts	0.4	2.7	5.0	-1.4	-1.6	-1.6	0.7	1.9	-2.2
Mean num. licks in bursts	0.3	0.8	2.3	-0.0	-0.2	1.5	-0.5	-0.5	1.3
Cd content in liver	1.1	1.2	2.0	0.9	0.9	0.4	-1.3	-1.4	1.4
Co content in liver	0.9	1.0	2.6	0.3	0.1	1.6	-0.8	-0.9	1.5
Cu content in liver	0.1	0.1	0.3	0.1	0.5	0.1	-0.5	-0.3	0.4
Fe content in liver	2.6	3.2	4.7	-2.0	-2.0	-0.2	1.8	2.2	-1.8
K content in liver	0.1	0.1	0.4	0.1	0.6	-0.4	-0.4	-0.1	0.2
Mg content in liver	1.3	1.4	2.8	0.8	1.7	0.2	-1.1	-1.2	1.5
Mn content in liver	0.4	0.4	1.0	0.0	0.4	0.8	-0.6	-0.7	1.0
Na content in liver	0.3	0.4	0.8	-0.2	0.7	0.9	0.4	-0.2	0.9
Rb content in liver	0.1	0.1	0.2	0.1	0.5	-0.0	0.2	-0.2	0.2
Se content in liver	0.1	0.1	0.2	0.3	0.5	-0.4	-0.3	-0.2	0.0
Sr content in liver	7.4	6.4	9.0	3.0	2.9	-0.6	-2.7	-3.0	2.0
Zn content in liver	2.0	2.4	3.4	1.6	1.9	-0.1	-1.7	-1.7	1.6
Bone: minimum diameter	3.6	6.9	11.9	-3.4	-2.7	2.5	3.2	2.4	-0.4
Time in familiar zone, hab. session 1	0.7	0.8	2.6	-0.4	0.1	1.6	1.2	0.0	0.8
Time in novel zone, hab. session 1	1.5	1.7	6.5	0.6	0.0	-2.6	-0.5	0.4	-1.6
Total zone transitions, hab. session 1	0.7	1.0	1.5	0.9	0.8	1.1	-0.8	-1.2	1.1
Total locomotion distance, hab. session 1	0.1	0.1	0.4	-0.1	-0.2	-0.4	0.1	0.2	-0.6
Locomotion velocity, hab. session 1	0.1	0.1	0.3	-0.3	-0.4	-0.2	0.1	0.2	-0.5
Time in familiar zone, hab. session 2	2.1	2.3	4.3	-1.0	-1.3	-1.2	1.6	1.6	-2.1
Time in novel zone, hab. session 2	0.6	0.7	1.6	0.6	0.7	0.9	-0.5	-0.8	1.3
Total zone transitions, hab. session 2	0.4	0.5	1.0	0.5	0.5	1.0	-0.5	-0.8	0.9
Total locomotion distance, hab. session 2	0.4	0.5	0.8	-0.8	-0.8	0.7	0.9	0.6	-0.2
Locomotion velocity, hab. session 2	0.3	0.4	0.8	-0.7	-0.5	0.9	0.7	0.3	0.1
Novel to familiar place preference ratio	1.1	1.4	2.1	-1.1	-1.4	-0.7	0.9	1.5	-1.5
Novelty place preference	0.9	1.1	1.8	-0.8	-1.1	-0.8	0.8	1.3	-1.3
Time in novel zone, NPP test	2.2	2.7	3.9	-1.4	-1.7	-0.9	1.8	2.0	-1.9
Total zone transitions, NPP test	0.3	0.5	1.6	-0.5	-0.7	1.3	-0.3	-0.1	0.6
Total locomotion distance, NPP test	0.2	0.3	0.9	-0.6	-0.9	0.8	0.1	0.3	0.1
Locomotion velocity, NPP test	0.4	0.6	1.5	-0.0	-0.4	0.9	-1.2	-0.6	0.8
Intraocular pressure	0.5	0.9	1.7	-0.8	-1.0	-0.3	0.8	1.1	-1.3
Delta distance traveled before/after self-admin	0.3	0.3	0.6	0.5	0.6	-0.6	-0.8	-0.5	-0.1
Delta ambulatory time before/after self-admin	0.2	0.3	0.9	0.4	0.5	-0.5	-0.9	-0.4	-0.2
Parametrial fat weight	16.9	39.8	80.2	-9.0	-7.0	6.5	5.9	5.6	-0.8
Pavlov. Cond. lever latency	0.6	0.8	2.0	0.7	1.0	-1.4	-1.0	-0.5	-0.3
Pavlov. Cond. magazine entry latency	1.1	1.4	2.7	-1.4	-1.7	0.9	1.2	1.2	-0.6
Pavlov. Cond. change in total contacts	3.9	4.2	7.9	-2.3	-2.4	1.2	2.8	2.1	-1.0
Pavlov. Cond. index score	1.3	1.6	2.7	-1.5	-1.6	1.2	1.5	1.2	-0.3
Pavlov. Cond. latency score	1.1	1.4	2.3	-1.3	-1.5	1.2	1.4	1.0	-0.3
Pavlov. Cond. lever contacts	0.9	1.1	2.2	-0.9	-1.1	1.5	1.4	0.7	0.1
Pavlov. Cond. magazine entry number	1.3	1.7	2.9	1.5	1.7	-1.0	-1.4	-1.3	0.5
Pavlov. Cond. intertrial magazine entries	1.7	2.1	4.4	-1.9	-2.1	1.6	0.8	1.2	-0.1
Pavlov. Cond. lever-magazine prob. diff.	1.8	2.2	3.7	-1.7	-1.9	1.2	1.7	1.4	-0.6
Pavlov. Cond. response bias	0.9	1.2	1.9	-1.1	-1.4	1.3	1.3	0.9	-0.1
Pavlov. Cond. lever latency	1.6	2.2	3.7	1.9	1.8	-0.1	-1.2	-1.7	1.3
Pavlov. Cond. magazine entry latency	0.3	0.5	1.1	-0.2	-0.5	-0.3	1.0	0.7	-1.1
Pavlov. Cond. change in total contacts	0.3	0.8	1.3	-1.1	-0.9	-0.2	0.7	1.1	-1.0
Pavlov. Cond. index score	0.7	1.2	1.6	-1.2	-1.3	0.0	0.9	1.3	-1.2
Pavlov. Cond. latency score	0.6	0.9	1.3	-1.2	-1.1	0.0	0.7	1.1	-1.1
Pavlov. Cond. lever contacts	0.9	1.4	2.4	-1.5	-1.4	0.4	1.0	1.3	-0.9
Pavlov. Cond. magazine entry number	0.1	0.2	0.3	0.1	0.4	-0.2	-0.6	-0.4	0.6
Pavlov. Cond. intertrial magazine entries	0.5	1.2	3.2	-1.4	-0.7	1.8	-0.3	0.2	1.2
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.7	1.0	-0.8	-0.9	0.0	0.7	1.0	-1.0
Pavlov. Cond. response bias	1.8	2.5	3.6	-1.8	-1.8	-0.2	1.6	1.9	-1.7
Time in closed arm before self-admin	0.1	0.1	0.2	0.4	0.4	0.0	-0.3	-0.5	0.1
Time in closed arm after self-admin	0.6	0.7	1.3	1.0	0.5	-0.0	-1.1	-1.0	0.8
Time in open arm before self-admin	0.7	0.8	1.6	1.3	1.2	-1.1	-0.8	-0.6	0.1
Time in open arm after self-admin	1.8	2.0	4.0	-1.0	-0.4	-1.4	2.0	1.5	-1.6
Bone: periosteal estimation	4.3	10.1	16.7	-4.1	-3.5	3.5	3.5	2.8	-0.2
Bone: periosteal perimeter	4.0	7.8	13.0	-3.6	-2.4	3.5	3.4	2.2	0.3
Bone: post-yield work	2.2	3.8	7.4	-2.2	-2.7	0.7	2.1	2.1	-1.3
Progressive ratio test 1 active lever presses	0.8	1.5	2.5	1.6	1.5	-0.6	-1.3	-1.3	0.7
Progressive ratio test 1 breakpoint	0.8	1.4	2.3	1.5	1.5	-0.5	-1.2	-1.3	0.7
Progressive ratio test 1 inactive lever presses	0.1	0.2	0.6	0.4	0.4	-0.5	-0.8	-0.4	-0.3
Progressive ratio test 2 active lever presses	0.6	0.8	1.3	0.9	1.1	0.0	-1.0	-1.0	0.8
Progressive ratio test 2 breakpoint	0.5	0.6	1.0	0.7	1.0	-0.1	-0.9	-0.9	0.7
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.7	-0.2	-0.1	-0.4	-0.8	0.1	-0.3
Incentive Sensitization - Responses	0.0	0.1	0.2	-0.2	0.3	0.3	-0.1	-0.2	0.4
Incentive Sensitization - Breakpoint	0.0	0.0	0.1	-0.2	0.2	0.1	-0.1	-0.1	0.3
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.4	-0.7	-0.1	-0.2	-0.3	0.1	-0.1
Progressive ratio	1.6	4.8	7.3	2.6	2.7	-1.6	-2.6	-2.2	0.8
Food seeking constrained by brief footshock	3.4	4.3	7.5	2.7	2.5	-2.0	-2.1	-1.9	0.1
Seeking ratio, punishment vs. effort	0.1	0.2	0.3	-0.2	-0.6	0.2	0.6	0.4	-0.3
Retroperitoneal fat weight	19.9	88.9	156.3	-12.5	-10.7	10.2	9.2	8.5	-1.5
Reaction time number correct	0.1	0.4	0.9	-0.7	-0.4	0.3	1.0	0.6	-0.4
Reaction time mean minus median	0.2	1.3	2.3	1.3	1.5	0.6	-0.6	-1.3	1.2
Reaction time mean minus median AUC	0.5	3.5	5.7	2.0	2.4	1.0	-1.0	-2.2	2.2
Reaction time num false alarms	0.7	1.2	2.9	-0.9	-1.7	1.4	0.9	0.8	0.0
Reaction time num false alarms AUC	0.6	1.3	2.5	-0.9	-1.5	1.6	1.2	0.7	0.2
Reaction time trials correct on left	0.1	0.4	0.9	-0.7	-0.4	0.3	1.0	0.6	-0.4
Reaction time trials on left	0.1	0.4	0.9	-0.7	-0.4	0.2	1.0	0.6	-0.4
Reaction time mean	1.8	4.1	7.9	2.8	2.7	-0.6	-1.7	-2.2	1.1
Reaction time mean AUC	2.1	5.2	9.3	3.0	3.0	-0.6	-2.1	-2.5	1.3
Median of all reaction times	2.8	4.5	8.9	3.0	2.8	-0.8	-1.9	-2.3	0.9
Reaction time omissions	0.1	0.2	0.5	0.3	0.4	-0.7	-0.4	-0.0	-0.6
Reaction time false alarm rate	0.7	0.9	2.2	-0.7	-1.5	1.4	0.8	0.6	0.2
Reaction time premature initiation rate	0.5	0.8	1.4	1.0	0.7	0.8	-0.7	-1.2	0.9
Reaction time premature initiations	0.1	0.4	0.8	0.4	0.5	0.9	-0.1	-0.8	0.7
Std. dev. reaction times	0.3	0.9	1.6	1.2	1.2	0.6	-0.3	-1.0	0.9
Reaction time trials completed	0.1	0.4	0.9	-0.7	-0.4	0.2	1.0	0.6	-0.4
Reaction time trials AUC	0.2	0.6	1.6	-1.0	-0.6	0.4	1.3	0.8	-0.4
Run reversals in cocaine runway, females	0.3	0.3	0.8	0.7	0.9	-0.6	-0.3	-0.5	-0.2
Run reversals in cocaine runway, males	1.8	2.0	3.3	1.5	1.4	-0.1	-1.8	-1.6	1.4
Latency to leave start box in cocaine runway	0.7	1.0	3.3	0.4	1.3	-1.8	0.5	0.1	-0.5
Latency to leave start box in cocaine runway, F	0.4	0.5	1.5	-0.3	0.4	-1.2	0.7	0.4	-0.6
Latency to leave start box in cocaine runway, M	0.6	0.5	2.0	0.7	1.4	-0.6	-0.0	-0.5	0.3
Std. dev. time between licks in bursts	0.5	1.0	2.4	-0.2	-0.9	-1.4	0.2	0.9	-1.5
Total sessions with >9 infusions	2.1	2.6	6.0	1.9	1.5	-0.2	-2.5	-1.7	0.8
Short access day 1 total inactive lever presses	0.5	1.0	1.9	-0.3	-0.6	-1.2	-1.3	0.4	-1.4
Short access day 10 total inactive lever presses	0.2	1.2	2.4	-1.5	-1.3	1.5	-0.0	0.5	0.5
Short access day 1 total infusions	0.4	0.7	2.7	0.9	0.5	-0.4	-1.6	-0.7	0.1
Short access day 10 total infusions	0.8	1.3	2.6	1.6	1.3	-1.1	-0.9	-1.1	0.3
Short access total infusions	0.9	1.3	2.9	1.5	1.0	-0.7	-1.7	-1.1	0.3
Short access day 1 locomotion	1.0	1.7	4.3	1.2	1.2	0.2	-2.1	-1.4	0.8
Short access day 10 total locomotion	0.3	1.3	2.2	1.5	1.2	0.1	-1.2	-1.3	0.9
Short access total locomotion	2.6	3.9	6.7	2.5	2.0	0.1	-2.6	-2.3	1.4
One hour access (0.3 mA shock)	0.5	0.6	2.3	0.4	0.7	-1.5	-0.6	-0.4	-0.7
Compulsive drug intake	0.7	1.0	2.0	-1.3	-1.4	-0.0	0.4	1.0	-1.1
One hour access (shock baseline)	0.5	1.4	2.0	1.2	1.4	-1.4	-1.3	-1.1	0.2
Social response proportion	1.1	1.4	4.1	-1.2	-2.0	0.9	0.8	1.2	-0.6
Social responses	1.8	2.4	3.9	-2.0	-1.8	1.2	1.7	1.5	-0.7
Social time	0.0	0.1	0.3	-0.2	0.1	0.2	0.5	0.1	0.0
Soleus weight	1.2	3.5	14.2	-1.4	-0.7	3.8	0.5	-0.2	2.1
Bone: stiffness	1.8	3.3	4.9	-2.2	-2.1	2.2	1.9	1.4	0.1
Tibialis anterior weight	0.2	0.5	1.4	-1.2	-0.7	0.3	0.6	0.9	-0.3
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.9	-0.6	-0.6	0.0	0.4	0.9	-0.6
Time to tail flick, vehicle, after self-admin	0.0	0.1	0.1	-0.0	0.4	0.3	0.2	-0.3	0.4
Time to tail flick, test, before self-admin	2.6	3.0	4.8	2.2	1.9	-0.1	-1.7	-2.1	1.5
Time to tail flick, test, after self-admin	1.1	1.1	2.1	-1.0	-1.1	-0.7	0.7	1.2	-1.4
Delta time to tail flick, vehicle, before/after SA	0.3	0.4	0.6	-0.0	0.8	0.6	0.3	-0.7	0.7
Delta time to tail flick, test, before/after SA	3.5	4.3	6.1	-2.4	-2.5	-0.1	2.0	2.5	-1.9
Tibia length	0.3	0.7	1.2	-0.8	-1.1	1.1	0.9	0.7	-0.1
Ambulatory time before self-admin	1.1	3.5	5.0	2.1	1.8	-0.1	-2.2	-2.2	1.7
Ambulatory time after self-admin	3.2	5.1	9.5	2.6	2.4	-1.1	-3.1	-2.5	1.2
Bone: tissue strength	0.3	0.3	1.2	0.0	0.2	-1.1	0.3	0.2	-0.7
Total heroin consumption	1.2	1.4	4.1	-1.2	-0.2	2.0	1.5	-0.0	0.8
Bone: trabecular number	2.1	3.9	7.0	-2.5	-2.7	1.1	1.7	2.1	-1.2
Bone: trabecular spacing	1.3	1.9	6.6	1.3	1.0	-2.6	-1.1	-0.4	-0.9
Bone: trabecular thickness	4.4	6.2	11.0	-3.3	-2.4	3.1	2.6	1.9	0.1
Bone: trabecular tissue density	0.5	0.9	2.8	0.9	0.3	-1.7	-1.1	-0.3	-0.6
Water consumed over 24 hours	0.1	0.2	0.5	-0.4	-0.0	0.7	0.3	-0.0	0.7
Number of responses in last shaping day	0.9	1.1	2.4	1.4	1.0	-0.1	-1.6	-1.0	0.5