Hub : Genes

Krtcap3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Krtcap3	0.84	0.16	0.0e+00	0.51	0.54	0.54	0.54	3.6e-65	6.9e-71	5.2e-72	1.2e-70
2	NAcc	gene expression	Krtcap3	0.03	0.03	2.3e-03	0.01	0.01	0.01	0.01	4.1e-03	1.0e-02	2.0e-02	2.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Bone: apparent density	4.8	8.8	9.1	-3.0	2.9
Area under the delay curve	0.5	0.8	1.0	-0.8	1.0
BMI with tail	0.2	0.7	0.9	0.9	-0.8
BMI without tail	0.3	1.9	1.9	1.3	-1.4
Body weight	1.9	8.4	9.3	3.0	-2.8
Weight adjusted by age	0.0	0.0	0.0	-0.1	-0.1
Bone surface	2.5	4.9	5.4	-2.3	2.1
Bone volume	2.5	5.0	5.5	-2.3	2.1
Breakpoint value in progressive ratio session	0.9	1.5	1.6	-1.2	1.3
Number of licking bursts	0.1	0.2	0.3	-0.4	0.5
Context. condit. distance diff. score	0.0	0.0	0.0	-0.1	-0.0
Locomotion velocity, session 1	0.0	0.0	0.1	0.0	-0.3
Locomotion distance, session 1	2.0	2.5	2.5	-1.6	1.6
Locomotion velocity, session 2	0.2	0.2	0.3	0.5	-0.3
Locomotion distance, session 2	0.0	0.0	0.0	0.0	-0.0
Locomotion velocity, session 3	0.6	0.7	0.9	-0.9	0.7
Locomotion distance, session 3	0.7	0.8	0.8	-0.9	0.9
Stereotopy head waving bouts, day 3	1.7	2.0	2.1	-1.5	1.4
Stereotopy head waving duration, day 3	0.1	0.1	0.1	-0.4	0.3
Locomotion velocity, session 7	1.0	1.1	1.5	-1.2	0.9
Locomotion distance, session 7	0.0	0.1	0.1	-0.3	-0.1
Stereotopy head waving bouts, day 7	0.0	0.0	0.0	0.1	0.2
Stereotopy head waving duration, day 7	0.2	0.3	0.4	-0.4	0.6
Locomotion velocity, session 8	0.1	0.1	0.2	-0.5	0.0
Locomotion distance, session 8	0.3	0.4	0.5	-0.7	0.6
Degree of sensitization distance	0.7	0.8	1.0	0.7	-1.0
Degree of sensitization stereotypy	0.2	0.2	0.4	0.6	-0.3
Conditioned locomotion	3.0	3.5	3.8	-1.8	1.9
Cocaine response after cond. corrected	1.0	1.5	1.7	-1.1	1.3
Cocaine response after cond. not corrected	2.0	2.9	3.2	-1.6	1.8
Cocaine response before conditioning	1.0	1.2	1.5	-1.2	1.0
Saline control response	0.4	0.6	0.7	-0.8	0.7
Bone: connectivity density	4.8	7.7	7.7	-2.8	2.8
Bone: cortical apparent density	0.6	0.9	1.0	-0.9	1.0
Bone: cortical area	0.8	1.2	1.4	-1.2	1.0
Bone: cortical porosity	0.9	1.0	1.1	-1.1	0.9
Bone: cortical porosity	1.1	1.2	1.4	-1.2	1.0
Bone: cortical thickness	0.0	0.0	0.0	-0.1	0.1
Bone: cortical thickness	1.6	1.9	2.1	-1.4	1.3
Bone: cortical tissue density	0.4	0.6	0.7	-0.7	0.8
Condit. Reinf. active minus inactive responses	0.4	0.4	0.5	0.7	-0.6
Condit. Reinf. active-inactive response ratio	0.5	0.5	0.6	0.8	-0.7
Condit. Reinf. active responses	0.3	0.4	0.5	-0.5	0.7
Condit. Reinf. inactive responses	1.8	2.3	2.5	-1.4	1.6
Incentive salience index mean	0.1	0.1	0.1	-0.3	0.4
Condit. Reinf. lever presses	0.9	1.4	1.5	-1.1	1.2
Condit. Reinf. active minus inactive responses	2.9	4.4	4.8	-2.0	2.2
Condit. Reinf. active-inactive response ratio	0.6	1.0	1.2	-0.9	1.1
Condit. Reinf. active responses	3.0	4.3	4.3	-2.1	2.1
Condit. Reinf. inactive responses	1.6	2.4	2.7	-1.6	1.4
Condit. Reinf. lever presses	2.0	2.9	3.1	-1.7	1.8
Condit. Reinf. lever reinforcers received	2.6	3.7	3.7	-1.9	1.9
Conditioned reinforcement - actives	0.1	0.4	0.8	-0.9	0.3
Conditioned reinforcement - inactives	1.1	3.1	3.5	-1.9	1.7
Conditioned locomotion	0.4	0.5	1.0	-0.2	-1.0
Patch foraging indifference point 0 sec	0.2	0.6	0.7	0.7	-0.8
Patch foraging indifference point AUC	0.6	1.4	1.7	-1.3	1.1
Delay disc. indifference point, 0s delay	1.9	2.2	2.9	1.7	-1.2
Delay disc. indifference point, 16s delay	0.6	0.8	1.0	-0.7	1.0
Delay disc. indifference point, 2s delay	0.1	0.1	0.1	0.2	-0.3
Delay disc. indifference point, 24s delay	2.3	3.6	4.9	-1.5	2.2
Delay disc. indifference point, 4s delay	0.0	0.0	0.0	-0.0	0.2
Delay disc. indifference point, 8s delay	0.3	0.5	0.6	-0.6	0.8
Indifference point function ln k	0.0	0.0	0.0	-0.0	-0.1
Indifference point function log k	0.0	0.0	0.0	-0.0	-0.1
Patch foraging total patch changes 0 sec	0.2	0.5	0.6	0.6	-0.8
Patch foraging total patch changes 12 sec	1.0	1.3	1.5	1.1	-1.2
Patch foraging total patch changes 18 sec	0.1	0.2	0.3	0.3	-0.6
Patch foraging total patch changes 24 sec	0.5	1.7	2.2	1.1	-1.5
Patch foraging total patch changes 6 sec	0.1	0.2	0.2	0.4	-0.4
Patch foraging time to switch 0 sec	0.0	0.0	0.1	0.0	0.3
Patch foraging water rate 0 sec	0.0	0.0	0.1	0.0	-0.3
Patch foraging water rate 12 sec	0.6	2.3	2.3	1.5	-1.5
Patch foraging water rate 18 sec	0.5	1.1	1.1	1.0	-1.0
Patch foraging water rate 24 sec	1.9	2.6	2.7	1.7	-1.6
Patch foraging water rate 6 sec	1.4	2.0	2.1	1.5	-1.4
Seeking ratio, delayed vs. immediate footshock	0.2	0.3	0.6	0.2	-0.7
Distance traveled before self-admin	0.0	0.0	0.0	0.1	0.1
Distance traveled after self-admin	1.2	2.1	2.5	1.6	-1.3
Extensor digitorum longus weight	4.7	18.6	18.6	-4.3	4.3
Bone: elastic displacement	0.6	0.8	0.8	-0.8	0.9
Bone: elastic work	1.0	1.4	1.5	-1.1	1.2
Bone: endosteal estimation	0.6	1.6	1.9	-1.4	1.1
Bone: endosteal perimeter	0.3	0.7	0.8	-0.9	0.8
Epididymis fat weight	10.9	55.2	56.1	7.5	-7.4
Delta time in closed arm before/after self-admin	0.0	0.0	0.0	0.0	0.2
Delta time in open arm before/after self-admin	0.1	0.2	0.2	-0.5	0.3
Diff in mean of infusions in LGA sessions	0.0	0.1	0.1	-0.4	-0.1
Delay discount exponential model param	1.1	1.5	1.7	1.1	-1.3
Extinction: sum of active levers before priming	0.6	0.9	0.9	-0.9	1.0
Active lever presses in extinction session 6	0.3	0.3	0.6	-0.8	0.3
Bone: final force	0.2	0.3	0.4	-0.7	0.4
Bone: final moment	0.2	0.4	0.6	-0.7	0.5
Food consumed during 24 hour testing period	0.1	0.2	0.2	-0.4	0.4
Glucose	0.3	0.5	0.6	0.6	-0.8
Heart weight	3.3	5.3	5.4	2.3	-2.3
Delay discount hyperbolic model param	0.7	0.9	1.1	0.9	-1.0
Intermittent access intake day 1-15 change	0.0	0.1	0.2	-0.0	-0.5
Intermittent access intake escalation	0.0	0.2	0.4	0.2	-0.6
Intermittent access intake escalation 2	0.1	0.2	0.4	0.1	-0.7
Intermitt. access day 1 inactive lever presses	0.1	0.8	0.9	-0.9	0.9
Intermitt. access day 15 inactive lever presses	0.8	4.3	5.1	-2.3	1.9
Intermitt. access escalation Index	0.2	0.6	0.7	0.6	-0.9
Intermittent access day 1 total infusions	1.4	4.1	4.6	-2.1	1.9
Intermittent access day 15 total infusions	0.5	1.2	1.6	-1.3	0.9
Intermittent access terminal intake (last 3 days)	1.0	1.8	2.3	-1.5	1.1
Intermittent access total infusions	1.4	1.6	1.9	-1.4	1.2
Intermittent access day 1 locomotion	1.3	2.4	2.6	-1.6	1.5
Intermittent access day 15 total locomotion	0.0	0.1	0.2	-0.5	0.0
Intermittent access total locomotion	0.2	0.2	0.4	-0.6	0.1
Intermittent access standard deviation	0.2	1.0	1.2	-1.1	0.9
Left kidney weight	0.0	0.0	0.0	0.1	0.0
Right kidney weight	0.1	1.0	1.5	1.2	-0.7
Cocaine induced anxiety	0.1	0.2	0.3	-0.5	0.3
Post-drug Anxiety	1.4	1.5	1.8	1.3	-1.1
Baseline Anxiety	2.2	3.7	4.4	2.1	-1.7
Tail length	0.4	2.1	2.2	1.4	-1.5
Length with tail	2.0	8.7	9.0	3.0	-2.9
Length without tail	0.4	2.1	2.3	1.5	-1.4
Times rat made contact with spout	2.5	2.9	3.1	-1.6	1.8
Lifetime Intake	1.4	1.7	2.2	-1.5	1.1
Liver weight, left	3.6	6.2	6.6	2.6	-2.4
Liver weight, right	10.1	17.7	18.2	4.3	-4.1
Locomotor activity	0.1	0.1	0.2	0.4	-0.1
Locomotor testing distance	0.2	0.5	0.7	-0.7	0.8
Locomotor testing rearing	0.3	1.1	1.3	-1.1	0.9
Locomotion in novel chamber	0.3	0.4	0.7	0.5	-0.8
Locomotion in novel chamber post-restriction	1.2	3.6	4.0	2.0	-1.8
Fecal boli incidents, locomotor time 1	0.1	0.2	0.3	-0.4	0.5
Change in fecal boli incidents, locomotor task	3.7	3.9	4.5	2.1	-1.8
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.1	0.2	0.2
Bouts of movement, locomotor time 1	2.0	2.5	2.8	-1.5	1.7
Total resting periods, locomotor time 1	2.2	2.5	2.7	-1.5	1.6
Rest time, locomotor task time 1	0.0	0.1	0.1	0.1	-0.3
Distance moved, locomotor task time 1	0.3	0.9	1.0	1.0	-0.9
Vertical activity count, locomotor time 1	0.1	0.4	0.6	0.8	-0.4
Time >=10cm from walls, locomotor time 2	0.1	0.2	0.3	-0.6	0.2
Bouts of movement, locomotor time 2	0.0	0.0	0.0	0.2	-0.1
Total resting periods, locomotor time 2	0.0	0.0	0.0	-0.1	0.1
Rest time, locomotor task time 2	1.1	1.9	2.0	-1.4	1.3
Distance moved, locomotor task time 2	1.0	1.4	1.5	1.1	-1.2
Vertical activity count, locomotor time 2	0.4	1.0	1.0	1.0	-1.0
Light reinforcement 1	1.6	7.3	7.4	-2.7	2.7
Light reinforcement 2	2.0	4.5	4.6	-2.1	2.1
Bone: marrow area	0.7	1.6	1.9	-1.4	1.1
Bone: maximum diameter	1.3	2.5	2.7	-1.7	1.5
Bone: maximum force	0.2	0.3	0.5	-0.7	0.5
Bone: maximum moment	0.3	0.5	0.7	-0.8	0.6
Mean time between licks in bursts	0.6	3.8	4.1	2.0	-1.9
Mean num. licks in bursts	0.0	0.1	0.1	-0.3	0.3
Cd content in liver	0.0	0.0	0.0	-0.1	0.1
Co content in liver	6.6	7.7	7.9	-2.8	2.8
Cu content in liver	0.1	0.1	0.1	-0.3	0.3
Fe content in liver	0.5	0.6	0.8	-0.9	0.7
K content in liver	0.5	0.5	0.6	-0.8	0.7
Mg content in liver	0.6	0.7	0.7	-0.9	0.8
Mn content in liver	0.1	0.1	0.2	-0.4	0.2
Na content in liver	0.4	0.4	0.6	-0.8	0.5
Rb content in liver	0.0	0.0	0.0	-0.1	0.2
Se content in liver	0.2	0.3	0.5	0.4	-0.7
Sr content in liver	0.1	0.1	0.1	0.3	-0.2
Zn content in liver	0.8	0.9	1.0	0.9	-1.0
Bone: minimum diameter	0.0	0.0	0.1	0.0	-0.2
Time in familiar zone, hab. session 1	0.8	0.8	0.9	0.9	-1.0
Time in novel zone, hab. session 1	0.5	0.6	0.6	0.7	-0.8
Total zone transitions, hab. session 1	0.1	0.2	0.2	-0.4	0.5
Total locomotion distance, hab. session 1	0.1	0.2	0.2	-0.5	0.3
Locomotion velocity, hab. session 1	1.0	1.5	1.5	-1.2	1.2
Time in familiar zone, hab. session 2	0.0	0.0	0.0	-0.2	-0.0
Time in novel zone, hab. session 2	0.4	0.4	0.6	0.7	-0.6
Total zone transitions, hab. session 2	0.2	0.3	0.3	-0.5	0.6
Total locomotion distance, hab. session 2	0.2	0.3	0.3	-0.5	0.6
Locomotion velocity, hab. session 2	0.4	0.6	0.7	-0.7	0.8
Novel to familiar place preference ratio	0.7	0.9	1.3	1.1	-0.8
Novelty place preference	1.2	1.5	1.9	1.4	-1.1
Time in novel zone, NPP test	1.5	1.9	2.3	1.5	-1.2
Total zone transitions, NPP test	1.6	2.3	2.4	-1.5	1.5
Total locomotion distance, NPP test	1.9	2.6	2.8	-1.5	1.7
Locomotion velocity, NPP test	3.3	4.7	5.2	-2.1	2.3
Intraocular pressure	3.6	5.9	7.1	2.7	-2.2
Delta distance traveled before/after self-admin	2.0	2.2	2.5	1.4	-1.6
Delta ambulatory time before/after self-admin	0.1	0.2	0.3	0.4	-0.5
Parametrial fat weight	11.1	26.2	26.8	5.2	-5.1
Pavlov. Cond. lever latency	1.9	2.4	2.5	1.6	-1.5
Pavlov. Cond. magazine entry latency	0.1	0.1	0.1	-0.3	0.3
Pavlov. Cond. change in total contacts	0.1	0.1	0.1	-0.2	0.3
Pavlov. Cond. index score	0.8	1.0	1.0	-1.0	1.0
Pavlov. Cond. latency score	0.8	1.0	1.1	-1.0	1.0
Pavlov. Cond. lever contacts	1.3	1.6	1.6	-1.3	1.2
Pavlov. Cond. magazine entry number	0.4	0.6	0.6	0.8	-0.7
Pavlov. Cond. intertrial magazine entries	1.5	1.8	2.0	-1.3	1.4
Pavlov. Cond. lever-magazine prob. diff.	1.6	2.0	2.1	-1.4	1.4
Pavlov. Cond. response bias	1.3	1.7	1.7	-1.3	1.3
Pavlov. Cond. lever latency	1.4	2.0	2.1	1.4	-1.4
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	-0.5	0.2
Pavlov. Cond. change in total contacts	0.4	1.0	1.1	-0.9	1.1
Pavlov. Cond. index score	0.8	1.3	1.4	-1.2	1.1
Pavlov. Cond. latency score	0.8	1.2	1.4	-1.2	1.0
Pavlov. Cond. lever contacts	1.0	1.5	1.6	-1.2	1.3
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	0.4	-0.2
Pavlov. Cond. intertrial magazine entries	2.0	4.3	4.7	2.2	-2.0
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.8	0.9	-1.0	0.8
Pavlov. Cond. response bias	1.6	2.3	2.4	-1.5	1.5
Time in closed arm before self-admin	0.6	1.0	1.5	0.7	-1.2
Time in closed arm after self-admin	1.2	1.4	1.7	1.0	-1.3
Time in open arm before self-admin	0.2	0.2	0.4	-0.2	0.7
Time in open arm after self-admin	1.6	1.7	1.8	-1.3	1.4
Bone: periosteal estimation	1.1	2.5	2.8	-1.7	1.5
Bone: periosteal perimeter	0.5	1.1	1.1	-1.0	1.0
Bone: post-yield work	0.7	1.3	1.5	-1.2	1.0
Progressive ratio test 1 active lever presses	0.7	1.2	1.6	-1.2	0.9
Progressive ratio test 1 breakpoint	0.8	1.3	1.6	-1.3	1.0
Progressive ratio test 1 inactive lever presses	0.8	2.0	2.4	-1.5	1.3
Progressive ratio test 2 active lever presses	0.0	0.0	0.1	-0.3	-0.1
Progressive ratio test 2 breakpoint	0.0	0.0	0.0	-0.2	-0.2
Progressive ratio test 2 inactive lever presses	0.2	0.5	0.9	-1.0	0.3
Incentive Sensitization - Responses	0.0	0.0	0.0	-0.1	-0.1
Incentive Sensitization - Breakpoint	0.0	0.1	0.1	0.1	-0.3
Sum of active levers in priming session hrs 5-6	1.2	1.1	1.3	-0.9	1.2
Progressive ratio	0.1	0.4	0.5	0.5	-0.7
Food seeking constrained by brief footshock	1.7	2.2	2.7	-1.7	1.3
Seeking ratio, punishment vs. effort	0.4	0.8	1.1	-0.8	1.0
Retroperitoneal fat weight	21.1	94.7	95.6	9.8	-9.7
Reaction time number correct	0.3	1.0	1.1	-1.0	1.1
Reaction time mean minus median	0.0	0.0	0.1	0.1	-0.3
Reaction time mean minus median AUC	0.0	0.1	0.1	0.3	-0.4
Reaction time num false alarms	0.1	0.1	0.2	-0.1	0.5
Reaction time num false alarms AUC	0.1	0.2	0.4	-0.2	0.6
Reaction time trials correct on left	0.3	1.0	1.1	-1.0	1.1
Reaction time trials on left	0.3	1.1	1.2	-1.0	1.1
Reaction time mean	0.8	1.8	1.9	1.3	-1.4
Reaction time mean AUC	0.6	1.4	1.5	1.2	-1.2
Median of all reaction times	1.2	1.8	1.9	1.3	-1.4
Reaction time omissions	0.1	0.1	0.1	-0.3	0.3
Reaction time false alarm rate	0.0	0.0	0.1	0.3	0.1
Reaction time premature initiation rate	0.1	0.2	0.3	0.5	-0.4
Reaction time premature initiations	0.0	0.0	0.0	-0.0	0.2
Std. dev. reaction times	0.2	0.7	0.9	0.7	-0.9
Reaction time trials completed	0.3	1.1	1.2	-1.0	1.1
Reaction time trials AUC	0.4	1.3	1.4	-1.1	1.2
Run reversals in cocaine runway, females	0.1	0.1	0.1	0.4	-0.0
Run reversals in cocaine runway, males	0.3	0.3	0.6	-0.0	0.7
Latency to leave start box in cocaine runway	0.5	0.6	0.9	-1.0	0.6
Latency to leave start box in cocaine runway, F	0.3	0.4	0.4	-0.6	0.7
Latency to leave start box in cocaine runway, M	0.1	0.1	0.1	-0.3	-0.3
Std. dev. time between licks in bursts	0.1	0.1	0.1	0.3	-0.3
Total sessions with >9 infusions	0.2	0.3	0.5	-0.7	0.2
Short access day 1 total inactive lever presses	3.5	7.0	7.7	-2.8	2.5
Short access day 10 total inactive lever presses	0.5	3.6	4.0	-1.8	2.0
Short access day 1 total infusions	1.2	2.3	3.4	-1.8	1.1
Short access day 10 total infusions	1.1	1.9	2.0	-1.4	1.3
Short access total infusions	0.4	0.5	0.9	-0.9	0.4
Short access day 1 locomotion	1.1	1.9	2.6	-1.6	1.1
Short access day 10 total locomotion	0.4	1.8	2.2	-1.5	1.2
Short access total locomotion	0.1	0.1	0.2	-0.4	-0.0
One hour access (0.3 mA shock)	0.5	0.6	0.9	-1.0	0.6
Compulsive drug intake	0.4	0.6	1.1	1.0	-0.1
One hour access (shock baseline)	0.6	1.5	2.2	-1.5	0.9
Social response proportion	0.5	0.6	0.8	0.6	-0.9
Social responses	0.1	0.2	0.3	0.3	-0.5
Social time	1.0	1.5	2.2	0.9	-1.5
Soleus weight	5.5	16.3	16.9	-4.0	4.1
Bone: stiffness	0.0	0.0	0.1	-0.3	0.1
Tibialis anterior weight	4.1	14.1	14.4	-3.8	3.7
Time to tail flick, vehicle, before self-admin	1.5	1.8	1.9	1.4	-1.3
Time to tail flick, vehicle, after self-admin	2.3	4.7	5.0	2.1	-2.2
Time to tail flick, test, before self-admin	0.1	0.1	0.1	-0.2	0.3
Time to tail flick, test, after self-admin	0.1	0.2	0.2	-0.5	0.3
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.0	-0.1	-0.2
Delta time to tail flick, test, before/after SA	1.4	1.7	2.0	-1.4	1.2
Tibia length	2.9	8.1	8.5	2.8	-2.9
Ambulatory time before self-admin	0.0	0.0	0.1	-0.0	0.2
Ambulatory time after self-admin	0.9	1.5	1.8	1.3	-1.1
Bone: tissue strength	0.5	0.6	0.7	0.8	-0.6
Total heroin consumption	4.2	5.0	5.1	-2.3	2.2
Bone: trabecular number	3.3	6.3	6.3	-2.5	2.5
Bone: trabecular spacing	2.5	3.7	4.3	2.1	-1.8
Bone: trabecular thickness	0.7	0.9	1.2	-1.1	0.9
Bone: trabecular tissue density	0.2	0.3	0.4	-0.6	0.5
Water consumed over 24 hours	0.5	1.0	1.1	-1.1	1.0
Number of responses in last shaping day	0.1	0.1	0.2	0.2	-0.4