Hub : Genes

Lbh

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 RMTg mRNA stability Lbh 0.57 0.34 7.3e-04 0.08 0.09 0.1 0.09 3.4e-03 2.2e-03 1.5e-03 2.9e-03
2 Adipose gene expression Lbh 0.28 0.11 0.0e+00 0.33 0.34 0.35 0.35 5.3e-38 8.9e-39 3.6e-40 2.0e-40
3 LHb gene expression Lbh 0.34 0.21 8.1e-05 0.14 0.12 0.14 0.15 2.8e-04 7.4e-04 3.8e-04 1.8e-04
4 OFC gene expression Lbh 0.29 0.16 5.8e-06 0.27 0.22 0.23 0.24 4.7e-07 5.8e-06 3.5e-06 2.4e-06
5 NAcc gene expression Lbh 0.04 0.03 1.7e-07 0.05 0.05 0.05 0.05 5.8e-08 4.3e-08 4.1e-08 4.6e-08
6 IC gene expression Lbh 0.39 0.22 1.4e-12 0.3 0.3 0.29 0.3 2.6e-13 6.3e-13 1.3e-12 6.5e-13
7 PL gene expression Lbh 0.15 0.08 0.0e+00 0.18 0.17 0.17 0.18 3.4e-19 7.7e-18 5.1e-18 2.2e-19
8 Brain gene expression Lbh 0.33 0.1 0.0e+00 0.38 0.39 0.39 0.4 3.1e-37 8.0e-39 2.3e-38 2.1e-39
9 BLA gene expression Lbh 0.05 0.04 2.3e-03 0.04 0.03 0.02 0.03 3.2e-03 6.7e-03 3.3e-02 1.1e-02
10 IL gene expression Lbh 0.3 0.19 5.0e-05 0.2 0.11 0.13 0.16 1.5e-05 1.6e-03 4.7e-04 9.9e-05
11 Brain mRNA stability Lbh 0.04 0.03 5.9e-03 0.01 0.01 0.02 0.01 1.2e-02 6.1e-02 1.2e-02 4.6e-02
12 pVTA gene expression Lbh 0.36 0.11 0.0e+00 0.42 0.39 0.43 0.43 3.9e-36 5.8e-33 1.0e-37 3.0e-37

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.30.64.8-2.2-1.1-0.5-0.4-0.3-0.3-0.2-0.2-0.1-0.20.30.1
Area under the delay curve0.50.61.5-1.2-0.7-0.3-0.2-0.6-0.8-0.7-0.7-0.9-0.7-1.0-0.9
BMI with tail0.20.61.60.60.40.30.2-0.2-0.5-0.8-0.8-1.0-1.1-1.3-1.1
BMI without tail0.10.20.80.50.3-0.1-0.0-0.3-0.4-0.4-0.5-0.8-0.9-0.5-0.5
Body weight0.10.62.01.40.80.50.4-0.0-0.4-0.6-0.6-0.8-0.7-1.4-1.0
Weight adjusted by age0.20.30.70.10.30.40.4-0.3-0.3-0.6-0.6-0.8-0.7-0.8-0.7
Bone surface0.30.52.6-1.6-1.2-0.9-0.8-0.5-0.4-0.3-0.4-0.3-0.20.2-0.0
Bone volume0.30.52.9-1.7-1.1-0.8-0.7-0.4-0.2-0.1-0.1-0.0-0.10.50.2
Breakpoint value in progressive ratio session1.11.31.9-1.3-0.9-0.7-0.7-1.1-1.2-1.3-1.3-1.3-1.1-1.0-1.4
Number of licking bursts1.11.82.6-0.9-1.4-1.5-1.5-1.4-1.3-1.4-1.4-1.1-0.9-1.6-1.3
Context. condit. distance diff. score0.10.10.40.3-0.0-0.2-0.2-0.4-0.3-0.4-0.5-0.5-0.3-0.6-0.5
Locomotion velocity, session 10.40.41.30.10.30.40.40.70.70.60.60.80.31.10.9
Locomotion distance, session 10.10.21.0-1.0-0.40.10.10.40.40.20.10.50.10.10.4
Locomotion velocity, session 20.10.20.3-0.10.20.40.40.30.40.40.40.60.60.30.5
Locomotion distance, session 20.10.10.2-0.40.00.40.40.50.40.40.40.50.50.20.4
Locomotion velocity, session 30.30.31.5-1.2-0.6-0.1-0.1-0.4-0.6-0.5-0.5-0.6-0.7-0.4-0.6
Locomotion distance, session 32.32.53.3-1.8-1.6-1.4-1.4-1.6-1.8-1.6-1.6-1.5-1.1-1.6-1.7
Stereotopy head waving bouts, day 30.81.01.6-1.1-1.2-1.3-1.2-1.0-0.8-1.0-1.0-0.9-0.7-0.6-0.7
Stereotopy head waving duration, day 30.00.00.1-0.1-0.0-0.1-0.00.10.20.10.00.20.00.30.3
Locomotion velocity, session 71.92.13.3-1.7-1.3-0.9-0.9-1.3-1.4-1.4-1.4-1.4-1.7-1.8-1.6
Locomotion distance, session 70.10.10.6-0.3-0.4-0.2-0.2-0.2-0.2-0.1-0.1-0.1-0.3-0.7-0.3
Stereotopy head waving bouts, day 70.10.10.7-0.10.00.00.10.00.10.10.10.20.90.30.3
Stereotopy head waving duration, day 70.10.10.5-0.7-0.20.10.1-0.00.10.10.00.20.70.30.3
Locomotion velocity, session 80.00.10.3-0.6-0.20.10.0-0.0-0.2-0.2-0.2-0.2-0.30.0-0.2
Locomotion distance, session 80.20.31.1-0.6-0.6-0.4-0.4-0.5-0.5-0.6-0.7-0.5-0.3-1.0-0.7
Degree of sensitization distance0.90.92.01.41.00.80.81.01.21.11.10.90.60.40.9
Degree of sensitization stereotypy0.10.10.8-0.00.10.20.30.10.10.10.20.30.9-0.10.1
Conditioned locomotion0.20.20.7-0.90.20.80.80.30.20.10.10.10.1-0.4-0.0
Cocaine response after cond. corrected0.20.30.6-0.8-0.30.10.10.30.50.50.60.70.70.60.8
Cocaine response after cond. not corrected0.10.10.9-0.9-0.4-0.1-0.10.00.20.20.30.30.20.40.4
Cocaine response before conditioning1.21.52.4-0.9-1.0-1.0-1.0-1.2-1.2-1.2-1.2-1.5-1.5-1.0-1.3
Saline control response1.92.53.6-1.9-1.9-1.8-1.8-1.6-1.5-1.4-1.4-1.5-1.6-1.2-1.3
Bone: connectivity density0.30.53.8-1.9-1.0-0.5-0.5-0.3-0.3-0.2-0.3-0.3-0.20.1-0.0
Bone: cortical apparent density0.00.00.2-0.40.10.20.2-0.1-0.2-0.3-0.3-0.0-0.30.3-0.0
Bone: cortical area0.60.91.4-1.2-1.2-1.1-1.0-1.0-0.8-0.9-0.9-0.8-0.8-0.9-0.8
Bone: cortical porosity2.42.64.00.20.91.41.41.51.81.91.92.02.01.41.9
Bone: cortical porosity2.42.64.50.00.81.41.41.51.81.92.02.02.11.41.9
Bone: cortical thickness0.00.00.10.20.1-0.1-0.0-0.00.2-0.00.00.30.2-0.10.1
Bone: cortical thickness0.10.10.3-0.40.00.40.40.20.40.30.40.50.6-0.10.3
Bone: cortical tissue density0.00.00.2-0.20.20.30.3-0.0-0.1-0.1-0.20.0-0.20.40.1
Condit. Reinf. active minus inactive responses0.10.10.20.2-0.2-0.4-0.4-0.2-0.0-0.3-0.3-0.1-0.4-0.3-0.2
Condit. Reinf. active-inactive response ratio0.20.20.4-0.4-0.5-0.6-0.6-0.5-0.3-0.5-0.5-0.3-0.5-0.1-0.3
Condit. Reinf. active responses0.30.30.9-0.5-0.7-0.6-0.7-0.6-0.4-0.5-0.5-0.3-0.6-0.9-0.5
Condit. Reinf. inactive responses0.10.10.2-0.20.00.30.30.20.30.30.40.40.2-0.40.3
Incentive salience index mean0.40.50.9-0.8-0.9-0.8-0.8-0.7-0.4-0.6-0.6-0.4-0.5-0.8-0.5
Condit. Reinf. lever presses0.60.83.1-1.8-1.3-0.9-0.9-0.8-0.5-0.6-0.5-0.4-0.5-1.0-0.5
Condit. Reinf. active minus inactive responses0.40.51.3-0.9-1.1-0.9-0.9-0.7-0.5-0.5-0.4-0.3-0.3-1.1-0.6
Condit. Reinf. active-inactive response ratio0.10.20.5-0.7-0.6-0.3-0.4-0.4-0.3-0.2-0.1-0.0-0.1-0.7-0.3
Condit. Reinf. active responses0.30.41.0-0.6-1.0-0.9-1.0-0.6-0.3-0.4-0.3-0.2-0.2-0.7-0.3
Condit. Reinf. inactive responses0.10.10.5-0.2-0.6-0.7-0.7-0.3-0.1-0.2-0.2-0.3-0.2-0.4-0.1
Condit. Reinf. lever presses0.20.30.6-0.7-0.8-0.6-0.6-0.5-0.3-0.4-0.3-0.3-0.4-0.7-0.4
Condit. Reinf. lever reinforcers received0.20.20.6-0.4-0.8-0.7-0.7-0.4-0.2-0.3-0.2-0.1-0.1-0.6-0.2
Conditioned reinforcement - actives0.20.40.9-0.6-0.7-0.7-0.6-0.8-0.6-0.9-0.9-0.4-0.2-0.0-0.5
Conditioned reinforcement - inactives0.60.91.8-1.3-1.3-1.3-1.3-0.9-0.8-0.7-0.6-0.5-0.90.4-0.4
Conditioned locomotion0.50.61.4-0.1-0.3-0.5-0.5-0.6-1.0-1.0-1.2-1.0-0.9-0.0-1.0
Patch foraging indifference point 0 sec0.10.10.4-0.6-0.4-0.4-0.3-0.3-0.4-0.3-0.30.10.1-0.1-0.0
Patch foraging indifference point AUC1.52.22.8-1.6-1.7-1.5-1.5-1.5-1.3-1.4-1.5-1.5-1.6-1.3-1.3
Delay disc. indifference point, 0s delay1.71.92.71.41.31.31.31.51.61.51.61.11.21.01.3
Delay disc. indifference point, 16s delay0.30.31.5-1.2-0.6-0.1-0.0-0.4-0.3-0.4-0.6-0.6-0.4-0.7-0.5
Delay disc. indifference point, 2s delay0.50.61.00.40.70.91.01.00.90.90.90.50.50.60.6
Delay disc. indifference point, 24s delay3.23.67.2-2.7-2.1-1.6-1.5-1.8-1.9-1.8-1.8-2.0-1.6-1.9-1.9
Delay disc. indifference point, 4s delay0.60.60.90.00.60.91.00.80.80.91.00.70.60.90.8
Delay disc. indifference point, 8s delay1.21.52.6-1.5-1.1-0.7-0.7-1.1-1.4-1.2-1.3-1.2-1.0-1.6-1.4
Indifference point function ln k0.61.01.70.61.01.11.10.90.81.01.01.31.31.01.0
Indifference point function log k0.61.01.70.61.01.11.10.90.81.01.01.31.31.01.0
Patch foraging total patch changes 0 sec0.10.20.4-0.6-0.5-0.5-0.4-0.4-0.5-0.4-0.3-0.0-0.0-0.3-0.2
Patch foraging total patch changes 12 sec0.10.10.40.20.40.40.50.60.30.40.20.20.1-0.00.3
Patch foraging total patch changes 18 sec1.11.72.5-1.3-1.5-1.6-1.5-1.3-1.3-1.3-1.4-1.3-1.3-0.9-1.0
Patch foraging total patch changes 24 sec0.10.10.40.50.60.50.60.20.0-0.0-0.1-0.1-0.00.1-0.1
Patch foraging total patch changes 6 sec0.20.30.7-0.8-0.5-0.3-0.3-0.5-0.7-0.6-0.6-0.4-0.4-0.7-0.6
Patch foraging time to switch 0 sec0.40.81.3-0.7-0.8-0.8-0.8-0.8-0.8-0.8-0.9-1.1-0.9-1.0-1.0
Patch foraging water rate 0 sec0.81.62.60.91.41.61.61.41.21.21.31.21.11.11.1
Patch foraging water rate 12 sec3.26.79.12.63.03.02.92.72.32.62.52.52.32.22.2
Patch foraging water rate 18 sec1.01.53.21.71.81.71.71.30.91.11.10.80.80.60.6
Patch foraging water rate 24 sec1.21.84.52.11.71.51.41.51.21.31.30.90.90.50.8
Patch foraging water rate 6 sec2.13.03.51.81.81.81.71.91.81.81.71.71.71.31.6
Seeking ratio, delayed vs. immediate footshock0.20.20.70.0-0.4-0.8-0.8-0.6-0.4-0.5-0.3-0.5-0.30.3-0.2
Distance traveled before self-admin0.40.51.3-0.1-0.6-0.8-0.8-0.8-0.8-0.8-0.8-0.3-0.2-1.1-0.8
Distance traveled after self-admin0.30.41.41.20.70.60.60.30.50.60.50.70.5-0.10.5
Extensor digitorum longus weight4.116.120.0-4.5-4.4-4.1-4.1-4.2-4.0-4.0-4.0-3.7-3.5-3.7-3.8
Bone: elastic displacement0.10.10.30.30.50.50.60.40.30.30.20.30.20.00.2
Bone: elastic work0.00.00.1-0.3-0.00.20.20.10.1-0.0-0.00.10.1-0.3-0.1
Bone: endosteal estimation0.61.42.4-1.6-1.5-1.4-1.3-1.0-1.2-0.9-1.0-1.1-1.0-0.8-0.9
Bone: endosteal perimeter1.12.43.2-1.5-1.7-1.8-1.7-1.4-1.5-1.5-1.5-1.6-1.5-1.2-1.5
Epididymis fat weight4.013.634.75.95.14.24.13.83.02.92.82.92.92.32.4
Delta time in closed arm before/after self-admin0.50.51.70.50.80.80.80.60.30.30.31.11.30.20.4
Delta time in open arm before/after self-admin3.53.56.1-1.8-1.9-1.9-1.9-1.9-1.7-1.6-1.9-2.3-2.5-1.2-1.6
Diff in mean of infusions in LGA sessions0.10.11.1-0.10.20.30.30.20.00.10.1-0.0-0.01.00.3
Delay discount exponential model param0.80.92.31.50.90.40.40.81.00.90.91.00.91.11.0
Extinction: sum of active levers before priming1.81.93.1-1.7-1.6-1.2-1.2-1.8-1.2-1.5-1.3-1.2-1.0-1.7-1.3
Active lever presses in extinction session 60.20.20.7-0.1-0.1-0.2-0.2-0.6-0.7-0.6-0.8-0.2-0.60.3-0.4
Bone: final force0.20.30.5-0.4-0.00.20.30.50.50.50.50.70.60.70.7
Bone: final moment0.10.20.4-0.4-0.10.10.20.50.40.50.40.60.50.60.6
Food consumed during 24 hour testing period0.10.10.2-0.1-0.4-0.4-0.4-0.4-0.3-0.2-0.3-0.10.0-0.3-0.2
Glucose0.10.10.60.80.2-0.3-0.2-0.2-0.2-0.2-0.2-0.2-0.20.2-0.1
Heart weight0.91.42.31.51.00.80.71.11.11.31.21.51.41.21.3
Delay discount hyperbolic model param0.40.41.31.10.60.10.10.50.60.50.50.70.60.80.7
Intermittent access intake day 1-15 change2.14.25.91.61.92.12.12.11.82.21.92.42.32.02.0
Intermittent access intake escalation2.65.47.71.72.02.22.22.42.22.52.32.82.62.42.4
Intermittent access intake escalation 23.74.36.61.81.61.81.72.02.12.22.02.62.42.32.3
Intermitt. access day 1 inactive lever presses0.83.05.1-1.0-1.3-1.4-1.4-1.5-2.1-1.7-1.8-2.2-2.3-1.6-2.1
Intermitt. access day 15 inactive lever presses0.81.73.8-1.5-1.8-1.9-1.9-1.5-1.4-1.0-0.7-0.6-0.70.5-0.5
Intermitt. access escalation Index0.10.10.20.40.20.10.10.30.50.40.50.2-0.10.00.3
Intermittent access day 1 total infusions1.82.93.9-1.9-2.0-1.9-1.9-1.8-1.6-1.6-1.4-1.6-1.9-1.2-1.5
Intermittent access day 15 total infusions0.20.30.8-0.2-0.10.20.20.30.40.60.60.90.50.80.7
Intermittent access terminal intake (last 3 days)0.10.20.7-0.3-0.3-0.1-0.10.10.40.30.40.50.40.80.5
Intermittent access total infusions0.10.10.3-0.6-0.4-0.3-0.3-0.3-0.1-0.2-0.0-0.0-0.40.3-0.0
Intermittent access day 1 locomotion2.63.36.0-1.3-1.7-2.0-2.0-1.9-1.6-1.9-1.8-2.2-2.4-1.0-1.7
Intermittent access day 15 total locomotion0.10.10.70.30.20.20.10.0-0.0-0.2-0.2-0.5-0.80.1-0.4
Intermittent access total locomotion0.10.10.60.10.10.00.0-0.0-0.0-0.2-0.2-0.4-0.80.3-0.3
Intermittent access standard deviation0.00.10.40.20.10.10.10.2-0.30.0-0.10.5-0.00.60.1
Left kidney weight0.00.10.30.10.10.1-0.0-0.1-0.4-0.4-0.5-0.2-0.50.0-0.3
Right kidney weight0.10.51.10.1-0.2-0.2-0.4-0.3-0.9-0.8-0.9-0.7-1.0-1.0-1.0
Cocaine induced anxiety0.30.40.6-0.4-0.7-0.6-0.7-0.7-0.7-0.5-0.7-0.5-0.8-0.3-0.5
Post-drug Anxiety0.30.31.01.00.70.60.60.60.50.60.40.40.10.20.4
Baseline Anxiety1.92.23.21.51.81.71.71.61.71.51.51.31.10.91.3
Tail length0.00.10.20.4-0.0-0.4-0.3-0.2-0.20.0-0.1-0.1-0.10.30.1
Length with tail0.10.52.61.61.10.80.70.60.30.40.30.30.5-0.20.1
Length without tail0.10.41.31.10.80.80.70.30.0-0.2-0.3-0.30.0-1.1-0.6
Times rat made contact with spout3.54.07.1-2.7-2.5-2.2-2.2-2.1-2.1-2.0-2.0-1.4-1.3-1.6-1.6
Lifetime Intake0.10.10.3-0.4-0.3-0.3-0.3-0.2-0.0-0.10.10.2-0.20.50.1
Liver weight, left0.40.71.01.00.90.60.70.70.70.80.91.00.80.80.9
Liver weight, right3.76.512.93.63.22.52.62.52.32.32.32.32.12.42.2
Locomotor activity0.20.30.5-0.30.10.40.40.70.70.70.60.50.50.50.7
Locomotor testing distance0.10.21.2-1.1-0.8-0.5-0.5-0.1-0.1-0.0-0.1-0.3-0.3-0.2-0.1
Locomotor testing rearing0.30.70.9-0.9-0.8-0.8-0.7-0.7-0.8-0.8-0.8-0.9-1.0-0.8-0.9
Locomotion in novel chamber0.20.20.70.80.80.40.40.30.2-0.00.0-0.10.90.40.1
Locomotion in novel chamber post-restriction2.74.45.52.32.32.22.12.12.02.22.12.31.81.61.9
Fecal boli incidents, locomotor time 10.20.41.5-0.30.10.30.30.40.50.50.31.21.20.20.6
Change in fecal boli incidents, locomotor task1.01.04.42.11.30.80.81.00.90.80.90.90.40.30.6
Time >=10cm from walls, locomotor time 15.25.67.71.92.42.82.72.62.52.52.52.42.31.22.1
Bouts of movement, locomotor time 11.51.72.9-1.7-1.4-1.1-1.1-1.4-1.5-1.2-1.1-1.3-1.1-1.6-1.3
Total resting periods, locomotor time 10.80.92.2-1.5-1.0-0.7-0.7-1.0-1.0-0.8-0.6-0.8-0.6-1.2-0.9
Rest time, locomotor task time 10.40.50.90.30.71.00.90.60.70.80.90.70.90.10.6
Distance moved, locomotor task time 10.10.20.60.60.40.20.20.30.40.40.40.40.20.80.5
Vertical activity count, locomotor time 10.10.20.80.90.60.50.50.50.50.40.30.20.20.30.3
Time >=10cm from walls, locomotor time 21.52.32.91.51.71.71.61.51.61.51.61.31.41.41.4
Bouts of movement, locomotor time 20.20.40.60.70.60.70.70.70.60.70.80.50.7-0.30.3
Total resting periods, locomotor time 20.10.10.40.40.30.30.30.20.20.20.30.10.3-0.6-0.1
Rest time, locomotor task time 20.60.81.2-0.9-0.8-0.8-0.8-0.9-1.0-0.9-0.8-1.1-0.8-0.8-0.9
Distance moved, locomotor task time 20.20.31.00.60.40.40.30.30.50.40.50.50.21.00.7
Vertical activity count, locomotor time 21.11.52.01.31.41.41.31.11.21.11.11.21.11.41.2
Light reinforcement 13.58.613.0-3.1-3.6-3.4-3.5-3.0-2.7-2.7-2.6-2.6-2.9-2.3-2.3
Light reinforcement 21.01.53.8-1.9-1.8-1.5-1.5-1.2-1.0-0.9-0.8-0.9-1.1-0.7-0.7
Bone: marrow area0.71.62.6-1.6-1.6-1.4-1.4-1.1-1.3-1.0-1.1-1.3-1.2-0.9-1.1
Bone: maximum diameter1.32.53.8-1.9-1.8-1.7-1.6-1.6-1.5-1.6-1.6-1.5-1.5-1.2-1.4
Bone: maximum force0.10.20.5-0.6-0.7-0.7-0.7-0.3-0.4-0.3-0.3-0.1-0.1-0.1-0.2
Bone: maximum moment0.10.20.6-0.7-0.7-0.8-0.7-0.4-0.4-0.4-0.4-0.2-0.3-0.2-0.3
Mean time between licks in bursts0.71.84.72.22.01.61.61.31.11.01.00.91.00.60.7
Mean num. licks in bursts0.10.10.7-0.6-0.10.10.10.10.10.10.10.20.10.80.3
Cd content in liver0.10.10.5-0.20.30.50.60.30.30.10.10.10.2-0.7-0.1
Co content in liver1.51.85.8-2.4-2.0-1.2-1.2-1.1-0.6-0.8-0.7-0.7-0.6-2.0-0.9
Cu content in liver0.40.51.3-1.1-0.9-0.7-0.7-0.7-0.5-0.5-0.6-0.4-0.2-1.1-0.6
Fe content in liver0.10.20.4-0.7-0.6-0.6-0.6-0.4-0.1-0.1-0.0-0.00.10.40.1
K content in liver2.72.63.3-1.6-1.7-1.6-1.6-1.6-1.7-1.7-1.8-1.5-1.4-1.5-1.6
Mg content in liver4.04.06.6-2.6-2.4-2.1-2.1-2.0-1.9-1.9-2.0-1.9-1.8-1.4-1.6
Mn content in liver0.80.91.7-0.8-0.6-0.5-0.6-0.8-1.1-1.1-1.1-1.3-1.1-0.5-1.1
Na content in liver1.71.82.9-1.2-1.6-1.7-1.7-1.5-1.3-1.3-1.3-1.3-1.3-0.5-1.0
Rb content in liver0.80.92.6-1.6-1.0-0.8-0.7-0.7-1.0-0.9-1.0-1.0-0.9-0.9-0.9
Se content in liver1.11.41.9-0.4-1.0-1.1-1.2-1.4-1.3-1.4-1.4-1.2-1.2-0.8-1.2
Sr content in liver0.20.20.40.0-0.5-0.6-0.6-0.5-0.1-0.3-0.2-0.3-0.4-0.4-0.2
Zn content in liver0.20.20.3-0.1-0.3-0.5-0.3-0.5-0.4-0.5-0.6-0.3-0.4-0.4-0.4
Bone: minimum diameter0.61.01.7-1.1-1.3-1.3-1.2-1.0-0.9-0.9-0.9-1.0-0.9-0.6-0.8
Time in familiar zone, hab. session 10.20.20.5-0.1-0.6-0.7-0.7-0.30.10.00.10.10.30.40.3
Time in novel zone, hab. session 10.70.71.71.11.31.31.21.00.60.60.50.50.60.20.3
Total zone transitions, hab. session 10.20.21.00.10.50.70.70.40.30.20.20.61.00.30.2
Total locomotion distance, hab. session 10.00.00.10.10.20.20.20.1-0.1-0.1-0.10.30.40.30.0
Locomotion velocity, hab. session 10.20.30.6-0.6-0.6-0.6-0.6-0.6-0.7-0.7-0.7-0.3-0.4-0.4-0.6
Time in familiar zone, hab. session 20.20.20.6-0.8-0.7-0.7-0.6-0.4-0.0-0.1-0.0-0.3-0.20.50.2
Time in novel zone, hab. session 20.30.31.11.00.80.60.60.50.20.30.20.30.3-0.3-0.0
Total zone transitions, hab. session 20.10.10.4-0.6-0.10.30.20.10.10.00.20.50.50.30.2
Total locomotion distance, hab. session 20.40.60.9-0.8-0.8-0.7-0.8-0.8-0.9-0.9-0.8-0.4-0.7-0.4-0.7
Locomotion velocity, hab. session 20.50.61.0-1.0-0.9-0.7-0.8-0.8-0.9-1.0-0.8-0.4-0.8-0.5-0.7
Novel to familiar place preference ratio1.31.53.21.61.71.51.51.10.70.80.81.01.80.60.6
Novelty place preference1.71.83.51.71.81.61.61.40.91.01.01.11.90.80.7
Time in novel zone, NPP test1.81.93.91.71.81.61.61.41.01.11.01.22.00.80.8
Total zone transitions, NPP test0.71.12.6-1.6-1.4-0.9-1.0-0.9-0.8-0.9-0.9-0.9-0.8-1.1-0.9
Total locomotion distance, NPP test0.91.21.9-1.2-1.4-1.1-1.3-1.1-1.1-1.2-1.1-0.9-0.6-1.2-1.1
Locomotion velocity, NPP test1.82.53.6-1.7-1.9-1.6-1.7-1.6-1.5-1.7-1.6-1.4-1.2-1.4-1.5
Intraocular pressure4.36.28.52.02.32.52.52.62.92.72.72.62.41.82.5
Delta distance traveled before/after self-admin1.11.22.21.51.41.11.10.91.01.11.00.70.51.41.1
Delta ambulatory time before/after self-admin0.50.61.00.91.00.90.90.70.70.80.60.40.11.00.8
Parametrial fat weight1.53.611.23.32.92.12.11.81.51.51.20.91.11.51.2
Pavlov. Cond. lever latency0.60.72.91.71.30.90.90.70.50.50.60.50.60.50.4
Pavlov. Cond. magazine entry latency1.01.32.3-0.9-1.4-1.5-1.5-1.1-1.0-1.0-1.1-0.9-0.7-1.1-0.9
Pavlov. Cond. change in total contacts0.50.51.5-0.7-1.2-1.2-1.2-0.8-0.4-0.4-0.5-0.2-0.4-0.5-0.2
Pavlov. Cond. index score0.60.81.8-1.3-1.3-1.2-1.2-0.8-0.7-0.6-0.7-0.5-0.5-0.7-0.5
Pavlov. Cond. latency score0.50.71.5-1.2-1.2-1.1-1.1-0.8-0.6-0.6-0.7-0.5-0.4-0.6-0.5
Pavlov. Cond. lever contacts0.60.82.4-1.6-1.3-0.9-0.9-0.7-0.6-0.6-0.7-0.6-0.7-0.7-0.6
Pavlov. Cond. magazine entry number0.60.71.80.71.21.31.31.00.70.70.80.50.30.60.5
Pavlov. Cond. intertrial magazine entries0.50.61.0-0.40.40.90.80.90.90.91.00.90.50.70.9
Pavlov. Cond. lever-magazine prob. diff.1.11.32.8-1.6-1.7-1.5-1.5-1.1-0.9-0.9-1.0-0.7-0.6-1.0-0.7
Pavlov. Cond. response bias0.60.71.9-1.4-1.4-1.2-1.2-0.8-0.6-0.5-0.6-0.4-0.4-0.5-0.4
Pavlov. Cond. lever latency0.30.40.80.90.80.50.50.50.50.50.50.40.40.90.5
Pavlov. Cond. magazine entry latency0.20.20.4-0.20.10.20.2-0.2-0.4-0.5-0.6-0.6-0.6-0.4-0.6
Pavlov. Cond. change in total contacts0.10.10.7-0.4-0.20.10.10.1-0.3-0.2-0.1-0.1-0.0-0.8-0.4
Pavlov. Cond. index score0.10.10.3-0.4-0.2-0.0-0.0-0.2-0.4-0.4-0.4-0.4-0.3-0.6-0.5
Pavlov. Cond. latency score0.10.20.3-0.5-0.3-0.0-0.1-0.3-0.4-0.5-0.5-0.5-0.4-0.6-0.5
Pavlov. Cond. lever contacts0.10.10.6-0.6-0.4-0.1-0.1-0.2-0.2-0.2-0.2-0.3-0.3-0.8-0.4
Pavlov. Cond. magazine entry number0.30.30.70.3-0.1-0.2-0.20.30.60.60.80.80.70.80.8
Pavlov. Cond. intertrial magazine entries1.11.74.12.01.20.60.61.01.21.21.31.31.41.61.4
Pavlov. Cond. lever-magazine prob. diff.0.00.00.1-0.10.10.30.30.1-0.0-0.1-0.1-0.10.0-0.2-0.1
Pavlov. Cond. response bias0.30.41.0-0.9-0.5-0.1-0.1-0.4-0.5-0.5-0.6-0.7-0.7-1.0-0.7
Time in closed arm before self-admin0.20.31.51.20.50.00.00.30.40.40.6-0.2-0.40.50.3
Time in closed arm after self-admin0.30.32.21.50.70.10.10.20.20.10.30.60.60.40.3
Time in open arm before self-admin0.60.61.20.10.71.11.10.80.70.60.61.11.10.20.5
Time in open arm after self-admin2.22.44.6-2.1-1.8-1.4-1.4-1.5-1.3-1.3-1.6-1.6-1.6-1.4-1.4
Bone: periosteal estimation1.12.33.6-1.9-1.9-1.7-1.7-1.4-1.4-1.3-1.4-1.4-1.3-1.2-1.3
Bone: periosteal perimeter1.32.22.9-1.5-1.7-1.7-1.7-1.4-1.3-1.4-1.4-1.4-1.3-1.4-1.4
Bone: post-yield work1.52.22.5-1.4-1.5-1.6-1.5-1.5-1.5-1.6-1.6-1.5-1.3-1.1-1.5
Progressive ratio test 1 active lever presses0.20.20.4-0.4-0.4-0.5-0.4-0.6-0.3-0.5-0.2-0.5-0.70.3-0.3
Progressive ratio test 1 breakpoint0.20.20.5-0.5-0.4-0.5-0.5-0.6-0.4-0.5-0.3-0.6-0.70.3-0.4
Progressive ratio test 1 inactive lever presses1.42.03.5-1.1-1.3-1.6-1.5-1.7-1.9-1.5-1.3-1.2-1.5-0.5-1.4
Progressive ratio test 2 active lever presses0.30.30.70.00.10.30.30.50.80.70.70.70.30.80.8
Progressive ratio test 2 breakpoint0.30.40.80.10.10.30.30.50.80.70.80.70.30.90.8
Progressive ratio test 2 inactive lever presses0.30.51.60.30.30.30.30.70.60.80.80.80.61.30.9
Incentive Sensitization - Responses0.71.02.10.30.20.40.40.91.51.31.21.10.91.01.4
Incentive Sensitization - Breakpoint0.70.92.00.40.20.50.40.91.41.21.21.00.81.01.4
Sum of active levers in priming session hrs 5-60.90.82.3-1.5-1.3-1.1-1.1-1.2-0.8-0.8-0.8-0.4-0.0-0.3-0.4
Progressive ratio0.10.21.21.10.60.20.10.30.20.00.10.0-0.10.50.1
Food seeking constrained by brief footshock0.10.11.1-1.0-0.4-0.2-0.2-0.2-0.0-0.1-0.0-0.1-0.10.20.2
Seeking ratio, punishment vs. effort0.30.51.0-0.70.10.50.70.60.80.80.80.91.00.30.8
Retroperitoneal fat weight3.816.352.87.36.14.64.64.02.92.92.62.52.42.72.3
Reaction time number correct0.10.10.2-0.30.00.20.20.20.30.40.40.50.50.40.5
Reaction time mean minus median0.10.21.0-0.30.30.50.50.40.30.30.1-0.2-0.11.00.3
Reaction time mean minus median AUC0.41.12.50.30.91.11.11.11.11.21.00.60.91.61.2
Reaction time num false alarms0.30.41.8-1.0-0.9-0.5-0.5-0.30.1-0.1-0.00.10.3-1.3-0.3
Reaction time num false alarms AUC0.50.83.1-1.2-1.3-0.9-1.0-0.7-0.3-0.5-0.4-0.3-0.1-1.8-0.6
Reaction time trials correct on left0.10.10.2-0.30.00.20.20.20.30.40.40.50.50.40.5
Reaction time trials on left0.10.10.3-0.3-0.00.20.20.20.30.40.40.50.50.40.5
Reaction time mean0.60.91.90.50.60.60.70.91.21.01.00.81.01.41.2
Reaction time mean AUC0.40.71.50.40.50.50.50.81.10.90.90.60.81.21.1
Median of all reaction times0.81.12.10.70.60.60.60.91.41.11.11.21.31.41.4
Reaction time omissions0.30.40.7-0.00.30.50.60.90.80.80.80.40.60.60.7
Reaction time false alarm rate0.81.13.5-0.9-1.3-1.1-1.1-0.9-0.6-0.9-0.8-0.7-0.5-1.9-1.0
Reaction time premature initiation rate0.30.41.0-0.1-0.2-0.1-0.1-0.4-0.8-0.6-0.6-0.8-0.9-1.0-1.0
Reaction time premature initiations0.10.10.3-0.2-0.10.00.1-0.1-0.4-0.2-0.2-0.3-0.4-0.6-0.5
Std. dev. reaction times0.40.71.80.40.80.90.90.90.90.80.70.40.61.30.9
Reaction time trials completed0.10.10.3-0.3-0.00.20.20.20.30.40.40.50.50.40.5
Reaction time trials AUC0.10.10.3-0.4-0.00.10.20.20.30.40.40.50.50.50.5
Run reversals in cocaine runway, females0.10.10.20.20.0-0.2-0.2-0.4-0.4-0.5-0.3-0.3-0.2-0.1-0.4
Run reversals in cocaine runway, males0.10.10.7-0.1-0.3-0.2-0.2-0.3-0.3-0.3-0.4-0.40.0-0.9-0.5
Latency to leave start box in cocaine runway0.30.30.6-0.7-0.6-0.4-0.4-0.7-0.5-0.6-0.6-0.5-0.6-0.3-0.4
Latency to leave start box in cocaine runway, F0.60.71.2-1.0-0.9-0.6-0.6-0.9-0.7-0.8-0.8-0.8-1.1-0.9-0.7
Latency to leave start box in cocaine runway, M0.40.41.00.50.60.60.60.40.40.50.50.71.00.80.6
Std. dev. time between licks in bursts0.00.10.20.40.30.30.30.10.00.1-0.0-0.00.1-0.4-0.2
Total sessions with >9 infusions0.40.51.50.60.40.10.20.30.60.50.80.91.01.20.8
Short access day 1 total inactive lever presses1.41.93.4-1.3-1.6-1.8-1.8-1.4-1.4-1.2-1.0-1.2-1.7-0.3-1.0
Short access day 10 total inactive lever presses0.30.71.9-1.0-0.9-1.0-1.0-0.9-1.4-0.7-0.5-0.8-0.40.3-0.6
Short access day 1 total infusions0.10.10.3-0.3-0.4-0.5-0.5-0.20.0-0.00.20.40.50.50.2
Short access day 10 total infusions0.40.51.1-0.9-1.0-1.1-1.0-0.8-0.5-0.5-0.1-0.4-0.20.2-0.2
Short access total infusions0.20.21.10.00.0-0.2-0.10.00.30.20.50.50.51.10.5
Short access day 1 locomotion0.60.71.6-0.8-1.0-1.3-1.2-1.2-0.9-0.9-0.7-0.5-0.20.1-0.6
Short access day 10 total locomotion1.22.13.6-1.0-1.0-1.1-1.2-1.3-1.4-1.7-1.8-1.9-1.9-1.1-1.7
Short access total locomotion0.10.10.80.70.50.20.20.20.1-0.10.0-0.1-0.00.90.1
One hour access (0.3 mA shock)0.70.81.9-0.2-0.10.30.30.41.10.91.01.41.01.31.3
Compulsive drug intake2.02.44.00.91.11.11.11.31.92.01.81.61.41.62.0
One hour access (shock baseline)0.10.20.5-0.7-0.7-0.5-0.5-0.4-0.1-0.4-0.20.30.1-0.0-0.0
Social response proportion0.20.20.30.20.60.60.60.1-0.3-0.2-0.2-0.5-0.6-0.2-0.5
Social responses3.54.57.0-0.7-1.6-2.1-2.2-2.2-2.7-2.4-2.5-2.2-2.1-1.7-2.4
Social time0.10.20.70.30.60.60.50.3-0.10.10.10.2-0.10.90.2
Soleus weight4.713.919.9-4.0-4.5-4.1-4.1-3.8-3.4-3.4-3.5-3.2-3.1-3.9-3.3
Bone: stiffness0.20.30.7-0.5-0.7-0.8-0.7-0.5-0.4-0.4-0.3-0.3-0.2-0.4-0.3
Tibialis anterior weight3.210.815.6-3.9-3.6-3.1-3.2-3.3-3.4-3.3-3.2-3.1-2.9-3.1-3.2
Time to tail flick, vehicle, before self-admin1.41.42.21.51.41.11.11.30.81.11.11.51.40.90.9
Time to tail flick, vehicle, after self-admin0.10.10.20.30.40.20.2-0.1-0.5-0.3-0.20.40.20.3-0.0
Time to tail flick, test, before self-admin0.20.21.00.20.30.20.10.00.10.20.31.00.60.40.5
Time to tail flick, test, after self-admin2.22.33.4-0.9-1.5-1.8-1.8-1.6-1.8-1.7-1.7-0.8-1.2-1.5-1.4
Delta time to tail flick, vehicle, before/after SA1.01.01.4-1.2-0.8-0.8-0.8-1.0-1.0-1.2-1.1-1.2-0.8-0.7-1.0
Delta time to tail flick, test, before/after SA3.23.33.8-1.7-1.9-1.9-1.9-1.7-1.9-1.8-1.9-1.9-1.7-1.8-1.8
Tibia length0.10.32.31.50.6-0.1-0.00.0-0.2-0.1-0.2-0.2-0.40.3-0.1
Ambulatory time before self-admin1.21.72.8-0.7-1.3-1.5-1.5-1.5-1.4-1.4-1.4-0.9-0.9-1.7-1.3
Ambulatory time after self-admin0.10.10.50.70.1-0.2-0.1-0.4-0.3-0.2-0.40.0-0.3-0.5-0.2
Bone: tissue strength0.60.70.80.80.80.80.80.80.80.80.90.90.90.80.8
Total heroin consumption1.21.42.7-1.7-1.5-1.4-1.4-1.5-1.1-1.2-1.1-0.8-0.6-0.4-0.8
Bone: trabecular number0.20.33.2-1.8-0.7-0.2-0.10.0-0.10.0-0.0-0.00.00.50.2
Bone: trabecular spacing0.10.10.50.7-0.0-0.3-0.4-0.40.1-0.1-0.0-0.1-0.1-0.4-0.1
Bone: trabecular thickness0.10.21.0-1.0-0.6-0.5-0.4-0.2-0.4-0.2-0.10.1-0.10.1-0.1
Bone: trabecular tissue density0.10.20.3-0.3-0.3-0.3-0.4-0.5-0.6-0.5-0.5-0.3-0.4-0.0-0.3
Water consumed over 24 hours0.81.11.9-1.4-1.4-1.2-1.2-1.1-0.9-0.9-1.0-0.8-0.7-0.7-0.7
Number of responses in last shaping day0.60.71.80.90.60.40.50.70.40.91.01.31.20.50.7