Hub : Genes

Lbh

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 RMTg mRNA stability Lbh 0.57 0.34 7.3e-04 0.08 0.09 0.1 0.09 3.4e-03 2.2e-03 1.5e-03 2.7e-03
2 Adipose gene expression Lbh 0.28 0.11 0.0e+00 0.33 0.34 0.35 0.35 5.3e-38 8.9e-39 3.6e-40 2.2e-40
3 LHb gene expression Lbh 0.34 0.21 8.1e-05 0.14 0.12 0.14 0.15 2.8e-04 7.4e-04 3.9e-04 1.8e-04
4 OFC gene expression Lbh 0.29 0.16 5.8e-06 0.27 0.22 0.23 0.24 4.7e-07 5.8e-06 3.5e-06 2.4e-06
5 NAcc gene expression Lbh 0.04 0.03 1.7e-07 0.05 0.05 0.05 0.05 5.8e-08 4.3e-08 4.1e-08 4.4e-08
6 IC gene expression Lbh 0.39 0.22 1.4e-12 0.3 0.3 0.29 0.3 2.6e-13 6.3e-13 1.3e-12 6.1e-13
7 PL gene expression Lbh 0.15 0.08 0.0e+00 0.18 0.17 0.17 0.18 3.4e-19 7.7e-18 5.1e-18 2.1e-19
8 Brain gene expression Lbh 0.33 0.1 0.0e+00 0.38 0.39 0.39 0.4 3.1e-37 8.0e-39 2.4e-38 2.2e-39
9 BLA gene expression Lbh 0.05 0.04 2.3e-03 0.04 0.03 0.02 0.03 3.2e-03 6.7e-03 3.3e-02 1.1e-02
10 IL gene expression Lbh 0.3 0.19 5.0e-05 0.2 0.11 0.13 0.16 1.5e-05 1.6e-03 4.8e-04 1.0e-04
11 Brain mRNA stability Lbh 0.04 0.03 5.9e-03 0.01 0.01 0.02 0.01 1.2e-02 6.1e-02 1.2e-02 4.3e-02
12 pVTA gene expression Lbh 0.36 0.11 0.0e+00 0.42 0.39 0.43 0.43 3.9e-36 5.8e-33 1.0e-37 2.9e-37

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.30.64.82.2-1.1-0.50.40.30.3-0.2-0.20.10.2-0.3-0.1
Area under the delay curve0.40.61.51.2-0.7-0.30.20.60.8-0.7-0.70.90.71.00.9
BMI with tail0.20.61.6-0.60.40.3-0.20.20.5-0.8-0.81.01.11.31.1
BMI without tail0.00.20.8-0.50.3-0.10.00.30.4-0.4-0.50.80.90.50.5
Body weight0.10.62.0-1.40.80.5-0.40.00.4-0.6-0.60.80.71.41.0
Weight adjusted by age0.10.30.7-0.10.30.4-0.40.30.3-0.6-0.60.80.70.80.7
Bone surface0.30.52.61.6-1.2-0.90.80.50.4-0.3-0.40.30.2-0.20.0
Bone volume0.20.52.91.7-1.1-0.80.70.40.2-0.1-0.10.00.1-0.5-0.2
Breakpoint value in progressive ratio session0.71.31.91.3-0.9-0.70.71.11.2-1.3-1.31.31.11.01.4
Number of licking bursts0.61.82.60.9-1.4-1.51.51.41.3-1.4-1.41.10.91.61.3
Context. condit. distance diff. score0.10.10.4-0.3-0.0-0.20.20.40.3-0.4-0.50.50.30.60.5
Locomotion velocity, session 10.40.41.3-0.10.30.4-0.4-0.7-0.70.60.6-0.8-0.3-1.1-0.9
Locomotion distance, session 10.10.21.01.0-0.40.1-0.1-0.4-0.40.20.1-0.5-0.1-0.1-0.4
Locomotion velocity, session 20.10.20.30.10.20.4-0.4-0.3-0.40.40.4-0.6-0.6-0.3-0.5
Locomotion distance, session 20.10.10.20.40.00.4-0.4-0.5-0.40.40.4-0.5-0.5-0.2-0.4
Locomotion velocity, session 30.30.31.51.2-0.6-0.10.10.40.6-0.5-0.50.60.70.40.6
Locomotion distance, session 32.12.53.31.8-1.6-1.41.41.61.8-1.6-1.61.51.11.61.7
Stereotopy head waving bouts, day 30.81.01.61.1-1.2-1.31.21.00.8-1.0-1.00.90.70.60.7
Stereotopy head waving duration, day 30.00.00.10.1-0.0-0.10.0-0.1-0.20.10.0-0.2-0.0-0.3-0.3
Locomotion velocity, session 71.92.13.31.7-1.3-0.90.91.31.4-1.4-1.41.41.71.81.6
Locomotion distance, session 70.10.10.50.3-0.4-0.20.20.20.2-0.1-0.10.10.30.70.3
Stereotopy head waving bouts, day 70.10.10.70.10.00.0-0.1-0.0-0.10.10.1-0.2-0.9-0.3-0.3
Stereotopy head waving duration, day 70.10.10.50.7-0.20.1-0.10.0-0.10.10.0-0.2-0.7-0.3-0.3
Locomotion velocity, session 80.00.10.30.6-0.20.1-0.00.00.2-0.2-0.20.20.3-0.00.2
Locomotion distance, session 80.20.31.10.6-0.6-0.40.40.50.5-0.6-0.70.50.31.00.7
Degree of sensitization distance0.90.92.0-1.41.00.8-0.8-1.0-1.21.11.1-0.9-0.6-0.4-0.9
Degree of sensitization stereotypy0.10.10.80.00.10.2-0.3-0.1-0.10.10.2-0.3-0.90.1-0.1
Conditioned locomotion0.20.20.70.90.20.8-0.8-0.3-0.20.10.1-0.1-0.10.40.0
Cocaine response after cond. corrected0.20.30.60.8-0.30.1-0.1-0.3-0.50.50.6-0.7-0.7-0.6-0.8
Cocaine response after cond. not corrected0.10.10.90.9-0.4-0.10.1-0.0-0.20.20.3-0.3-0.2-0.4-0.4
Cocaine response before conditioning1.21.52.40.9-1.0-1.01.01.21.2-1.2-1.21.51.51.01.3
Saline control response1.82.53.61.9-1.9-1.81.81.61.5-1.4-1.41.51.61.21.3
Bone: connectivity density0.30.53.81.9-1.0-0.50.50.30.3-0.2-0.30.30.2-0.10.0
Bone: cortical apparent density0.00.00.20.40.10.2-0.20.10.2-0.3-0.30.00.3-0.30.0
Bone: cortical area0.60.91.41.2-1.2-1.11.01.00.8-0.9-0.90.80.80.90.8
Bone: cortical porosity2.42.64.0-0.20.91.4-1.4-1.5-1.81.91.9-2.0-2.0-1.4-1.9
Bone: cortical porosity2.42.74.5-0.00.81.4-1.4-1.5-1.81.92.0-2.0-2.1-1.4-1.9
Bone: cortical thickness0.00.00.1-0.20.1-0.10.00.0-0.2-0.00.0-0.3-0.20.1-0.1
Bone: cortical thickness0.10.10.30.40.00.4-0.4-0.2-0.40.30.4-0.5-0.60.1-0.3
Bone: cortical tissue density0.00.00.20.20.20.3-0.30.00.1-0.1-0.2-0.00.2-0.4-0.1
Condit. Reinf. active minus inactive responses0.10.10.2-0.2-0.2-0.40.40.20.0-0.3-0.30.10.40.30.2
Condit. Reinf. active-inactive response ratio0.20.20.40.4-0.5-0.60.60.50.3-0.5-0.50.30.50.10.3
Condit. Reinf. active responses0.30.30.90.5-0.7-0.60.70.60.4-0.5-0.50.30.60.90.5
Condit. Reinf. inactive responses0.10.10.20.20.00.3-0.3-0.2-0.30.30.4-0.4-0.20.4-0.3
Incentive salience index mean0.40.50.90.8-0.9-0.80.80.70.4-0.6-0.60.40.50.80.5
Condit. Reinf. lever presses0.50.83.11.8-1.3-0.90.90.80.5-0.6-0.50.40.51.00.5
Condit. Reinf. active minus inactive responses0.40.51.30.9-1.1-0.90.90.70.5-0.5-0.40.30.31.10.6
Condit. Reinf. active-inactive response ratio0.10.20.50.7-0.6-0.30.40.40.3-0.2-0.10.00.10.70.3
Condit. Reinf. active responses0.20.41.00.6-1.0-0.91.00.60.3-0.4-0.30.20.20.70.3
Condit. Reinf. inactive responses0.10.10.50.2-0.6-0.70.70.30.1-0.2-0.20.30.20.40.1
Condit. Reinf. lever presses0.20.30.60.7-0.8-0.60.60.50.3-0.4-0.30.30.40.70.4
Condit. Reinf. lever reinforcers received0.10.20.60.4-0.8-0.70.70.40.2-0.3-0.20.10.10.60.2
Conditioned reinforcement - actives0.10.40.90.6-0.7-0.70.60.80.6-0.9-0.90.40.20.00.5
Conditioned reinforcement - inactives0.30.91.81.3-1.3-1.31.30.90.8-0.7-0.60.50.9-0.40.4
Conditioned locomotion0.40.61.40.1-0.3-0.50.50.61.0-1.0-1.21.00.90.01.0
Patch foraging indifference point 0 sec0.00.10.40.6-0.4-0.40.30.30.4-0.3-0.3-0.1-0.10.10.0
Patch foraging indifference point AUC0.92.22.81.6-1.7-1.51.51.51.3-1.4-1.51.51.61.31.3
Delay disc. indifference point, 0s delay1.71.92.7-1.41.31.3-1.3-1.5-1.61.51.6-1.1-1.2-1.0-1.3
Delay disc. indifference point, 16s delay0.20.31.51.2-0.6-0.10.00.40.3-0.4-0.60.60.40.70.5
Delay disc. indifference point, 2s delay0.50.61.0-0.40.70.9-1.0-1.0-0.90.90.9-0.5-0.5-0.6-0.6
Delay disc. indifference point, 24s delay2.33.67.22.7-2.1-1.61.51.81.9-1.8-1.82.01.61.91.9
Delay disc. indifference point, 4s delay0.60.60.9-0.00.60.9-1.0-0.8-0.80.91.0-0.7-0.6-0.9-0.8
Delay disc. indifference point, 8s delay0.91.52.61.5-1.1-0.70.71.11.4-1.2-1.31.21.01.61.4
Indifference point function ln k0.31.01.7-0.61.01.1-1.1-0.9-0.81.01.0-1.3-1.3-1.0-1.0
Indifference point function log k0.31.01.7-0.61.01.1-1.1-0.9-0.81.01.0-1.3-1.3-1.0-1.0
Patch foraging total patch changes 0 sec0.10.20.40.6-0.5-0.50.40.40.5-0.4-0.30.00.00.30.2
Patch foraging total patch changes 12 sec0.10.10.4-0.20.40.4-0.5-0.6-0.30.40.2-0.2-0.10.0-0.3
Patch foraging total patch changes 18 sec0.71.72.51.3-1.5-1.61.51.31.3-1.3-1.41.31.30.91.0
Patch foraging total patch changes 24 sec0.00.10.4-0.50.60.5-0.6-0.2-0.0-0.0-0.10.10.0-0.10.1
Patch foraging total patch changes 6 sec0.20.30.70.8-0.5-0.30.30.50.7-0.6-0.60.40.40.70.6
Patch foraging time to switch 0 sec0.20.81.30.7-0.8-0.80.80.80.8-0.8-0.91.10.91.01.0
Patch foraging water rate 0 sec0.41.62.6-0.91.41.6-1.6-1.4-1.21.21.3-1.2-1.1-1.1-1.1
Patch foraging water rate 12 sec1.76.79.1-2.63.03.0-2.9-2.7-2.32.62.5-2.5-2.3-2.2-2.2
Patch foraging water rate 18 sec0.71.53.2-1.71.81.7-1.7-1.3-0.91.11.1-0.8-0.8-0.6-0.6
Patch foraging water rate 24 sec1.21.84.5-2.11.71.5-1.4-1.5-1.21.31.3-0.9-0.9-0.5-0.8
Patch foraging water rate 6 sec2.03.03.5-1.81.81.8-1.7-1.9-1.81.81.7-1.7-1.7-1.3-1.6
Seeking ratio, delayed vs. immediate footshock0.20.20.7-0.0-0.4-0.80.80.60.4-0.5-0.30.50.3-0.30.2
Distance traveled before self-admin0.20.51.30.1-0.6-0.80.80.80.8-0.8-0.80.30.21.10.8
Distance traveled after self-admin0.20.41.4-1.20.70.6-0.6-0.3-0.50.60.5-0.7-0.50.1-0.5
Extensor digitorum longus weight4.016.120.04.5-4.4-4.14.14.24.0-4.0-4.03.73.53.73.8
Bone: elastic displacement0.10.10.3-0.30.50.5-0.6-0.4-0.30.30.2-0.3-0.2-0.0-0.2
Bone: elastic work0.00.00.10.3-0.00.2-0.2-0.1-0.1-0.0-0.0-0.1-0.10.30.1
Bone: endosteal estimation0.61.42.41.6-1.5-1.41.31.01.2-0.9-1.01.11.00.80.9
Bone: endosteal perimeter1.02.43.21.5-1.7-1.81.71.41.5-1.5-1.51.61.51.21.5
Epididymis fat weight2.713.634.7-5.95.14.2-4.1-3.8-3.02.92.8-2.9-2.9-2.3-2.4
Delta time in closed arm before/after self-admin0.50.51.7-0.50.80.8-0.8-0.6-0.30.30.3-1.1-1.3-0.2-0.4
Delta time in open arm before/after self-admin2.93.56.11.8-1.9-1.91.91.91.7-1.6-1.92.32.51.21.6
Diff in mean of infusions in LGA sessions0.10.11.10.10.20.3-0.3-0.2-0.00.10.10.00.0-1.0-0.3
Delay discount exponential model param0.70.92.3-1.50.90.4-0.4-0.8-1.00.90.9-1.0-0.9-1.1-1.0
Extinction: sum of active levers before priming1.31.93.11.7-1.6-1.21.21.81.2-1.5-1.31.21.01.71.3
Active lever presses in extinction session 60.20.20.70.1-0.1-0.20.20.60.7-0.6-0.80.20.6-0.30.4
Bone: final force0.20.30.50.4-0.00.2-0.3-0.5-0.50.50.5-0.7-0.6-0.7-0.7
Bone: final moment0.10.20.40.4-0.10.1-0.2-0.5-0.40.50.4-0.6-0.5-0.6-0.6
Food consumed during 24 hour testing period0.00.10.20.1-0.4-0.40.40.40.3-0.2-0.30.1-0.00.30.2
Glucose0.10.10.6-0.80.2-0.30.20.20.2-0.2-0.20.20.2-0.20.1
Heart weight0.91.42.3-1.51.00.8-0.7-1.1-1.11.31.2-1.5-1.4-1.2-1.3
Delay discount hyperbolic model param0.30.41.3-1.10.60.1-0.1-0.5-0.60.50.5-0.7-0.6-0.8-0.7
Intermittent access intake day 1-15 change0.84.25.9-1.61.92.1-2.1-2.1-1.82.21.9-2.4-2.3-2.0-2.0
Intermittent access intake escalation1.05.47.7-1.72.02.2-2.2-2.4-2.22.52.3-2.8-2.6-2.4-2.4
Intermittent access intake escalation 22.54.36.6-1.81.61.8-1.7-2.0-2.12.22.0-2.6-2.4-2.3-2.3
Intermitt. access day 1 inactive lever presses0.23.05.11.0-1.3-1.41.41.52.1-1.7-1.82.22.31.72.1
Intermitt. access day 15 inactive lever presses0.31.73.81.5-1.8-1.91.91.51.4-1.0-0.70.60.7-0.50.5
Intermitt. access escalation Index0.00.10.2-0.40.20.1-0.1-0.3-0.50.40.5-0.20.1-0.0-0.3
Intermittent access day 1 total infusions1.02.93.91.9-2.0-1.91.91.81.6-1.6-1.41.61.91.21.5
Intermittent access day 15 total infusions0.10.30.80.2-0.10.2-0.2-0.3-0.40.60.6-0.9-0.5-0.8-0.7
Intermittent access terminal intake (last 3 days)0.10.20.70.3-0.3-0.10.1-0.1-0.40.30.4-0.5-0.4-0.8-0.5
Intermittent access total infusions0.10.10.30.6-0.4-0.30.30.30.1-0.2-0.00.00.4-0.30.0
Intermittent access day 1 locomotion1.83.36.01.3-1.7-2.02.01.91.6-1.9-1.82.22.41.01.7
Intermittent access day 15 total locomotion0.00.10.7-0.30.20.2-0.1-0.00.0-0.2-0.20.50.8-0.10.4
Intermittent access total locomotion0.10.10.6-0.10.10.0-0.00.00.0-0.2-0.20.40.8-0.30.3
Intermittent access standard deviation0.00.10.4-0.20.10.1-0.1-0.20.30.0-0.1-0.50.0-0.6-0.1
Left kidney weight0.00.10.3-0.10.10.10.00.10.4-0.4-0.50.20.5-0.00.3
Right kidney weight0.10.51.1-0.1-0.2-0.20.40.30.9-0.8-0.90.71.01.01.0
Cocaine induced anxiety0.10.40.60.4-0.7-0.60.70.70.7-0.5-0.70.50.80.30.5
Post-drug Anxiety0.30.31.0-1.00.70.6-0.6-0.6-0.50.60.4-0.4-0.1-0.2-0.4
Baseline Anxiety1.32.23.2-1.51.81.7-1.7-1.6-1.71.51.5-1.3-1.1-0.9-1.3
Tail length0.00.10.2-0.4-0.0-0.40.30.20.20.0-0.10.10.1-0.3-0.1
Length with tail0.10.52.6-1.61.10.8-0.7-0.6-0.30.40.3-0.3-0.50.2-0.1
Length without tail0.10.41.3-1.10.80.8-0.7-0.3-0.0-0.2-0.30.3-0.01.10.6
Times rat made contact with spout3.54.07.12.7-2.5-2.22.22.12.1-2.0-2.01.41.31.61.6
Lifetime Intake0.10.10.30.4-0.3-0.30.30.20.0-0.10.1-0.20.2-0.5-0.1
Liver weight, left0.40.71.0-1.00.90.6-0.7-0.7-0.70.80.9-1.0-0.8-0.8-0.9
Liver weight, right3.76.512.9-3.63.22.5-2.6-2.5-2.32.32.3-2.3-2.1-2.4-2.2
Locomotor activity0.20.30.50.30.10.4-0.4-0.7-0.70.70.6-0.5-0.5-0.5-0.7
Locomotor testing distance0.10.21.21.1-0.8-0.50.50.10.1-0.0-0.10.30.30.20.1
Locomotor testing rearing0.20.70.90.9-0.8-0.80.70.70.8-0.8-0.80.91.00.80.9
Locomotion in novel chamber0.20.20.7-0.80.80.4-0.4-0.3-0.2-0.00.00.1-0.9-0.4-0.1
Locomotion in novel chamber post-restriction1.54.45.5-2.32.32.2-2.1-2.1-2.02.22.1-2.3-1.8-1.6-1.9
Fecal boli incidents, locomotor time 10.10.41.50.30.10.3-0.3-0.4-0.50.50.3-1.2-1.2-0.2-0.6
Change in fecal boli incidents, locomotor task0.91.04.4-2.11.30.8-0.8-1.0-0.90.80.9-0.9-0.4-0.3-0.6
Time >=10cm from walls, locomotor time 14.55.67.7-1.92.42.8-2.7-2.6-2.52.52.5-2.4-2.3-1.2-2.1
Bouts of movement, locomotor time 11.31.72.91.7-1.4-1.11.11.41.5-1.2-1.11.31.11.61.3
Total resting periods, locomotor time 10.70.92.21.5-1.0-0.70.71.01.0-0.8-0.60.80.61.20.9
Rest time, locomotor task time 10.30.50.9-0.30.71.0-0.9-0.6-0.70.80.9-0.7-0.9-0.1-0.6
Distance moved, locomotor task time 10.10.20.6-0.60.40.2-0.2-0.3-0.40.40.4-0.4-0.2-0.8-0.5
Vertical activity count, locomotor time 10.00.20.8-0.90.60.5-0.5-0.5-0.50.40.3-0.2-0.2-0.3-0.3
Time >=10cm from walls, locomotor time 20.82.32.9-1.51.71.7-1.6-1.5-1.61.51.6-1.3-1.4-1.4-1.4
Bouts of movement, locomotor time 20.10.40.6-0.70.60.7-0.7-0.7-0.60.70.8-0.5-0.70.3-0.3
Total resting periods, locomotor time 20.00.10.4-0.40.30.3-0.3-0.2-0.20.20.3-0.1-0.30.60.1
Rest time, locomotor task time 20.50.81.20.9-0.8-0.80.80.91.0-0.9-0.81.10.80.80.9
Distance moved, locomotor task time 20.20.31.0-0.60.50.4-0.3-0.3-0.50.40.5-0.5-0.2-1.0-0.7
Vertical activity count, locomotor time 20.71.52.0-1.31.41.4-1.3-1.1-1.21.11.1-1.2-1.1-1.4-1.2
Light reinforcement 11.98.613.03.1-3.6-3.43.53.02.7-2.7-2.62.62.92.32.3
Light reinforcement 20.71.53.81.9-1.8-1.51.51.21.0-0.9-0.80.91.10.70.7
Bone: marrow area0.71.62.61.6-1.6-1.41.41.11.3-1.0-1.11.31.20.91.1
Bone: maximum diameter1.32.53.81.9-1.8-1.71.61.61.5-1.6-1.61.51.51.21.4
Bone: maximum force0.10.20.50.6-0.7-0.70.70.30.4-0.3-0.30.10.10.10.2
Bone: maximum moment0.10.20.60.7-0.7-0.80.70.40.4-0.4-0.40.20.30.20.3
Mean time between licks in bursts0.31.84.7-2.22.01.6-1.6-1.3-1.11.01.0-0.9-1.0-0.6-0.7
Mean num. licks in bursts0.00.10.70.6-0.10.1-0.1-0.1-0.10.10.1-0.2-0.1-0.8-0.3
Cd content in liver0.10.10.50.20.30.5-0.6-0.3-0.30.10.1-0.1-0.20.70.1
Co content in liver1.51.75.82.4-2.0-1.21.21.10.6-0.8-0.70.70.62.00.9
Cu content in liver0.40.51.31.1-0.9-0.70.70.70.5-0.5-0.60.40.21.10.6
Fe content in liver0.10.20.40.7-0.6-0.60.60.40.1-0.1-0.00.0-0.1-0.4-0.1
K content in liver2.72.63.31.6-1.7-1.61.61.61.7-1.7-1.81.51.41.51.6
Mg content in liver3.74.06.62.6-2.4-2.12.12.01.9-1.9-2.01.91.81.41.6
Mn content in liver0.80.91.70.8-0.6-0.50.60.81.1-1.1-1.11.31.10.51.1
Na content in liver1.61.82.91.2-1.6-1.71.71.51.3-1.3-1.31.31.30.61.0
Rb content in liver0.80.92.61.6-1.0-0.80.70.71.0-0.9-1.01.00.90.90.9
Se content in liver1.11.41.90.4-1.0-1.11.21.41.3-1.4-1.41.21.20.81.2
Sr content in liver0.20.20.4-0.0-0.5-0.60.60.50.1-0.3-0.20.30.40.40.2
Zn content in liver0.10.20.30.1-0.3-0.50.30.50.4-0.5-0.60.30.40.40.4
Bone: minimum diameter0.51.01.71.1-1.3-1.31.21.00.9-0.9-0.91.00.90.60.8
Time in familiar zone, hab. session 10.10.20.50.1-0.6-0.70.70.3-0.10.00.1-0.1-0.3-0.4-0.3
Time in novel zone, hab. session 10.60.71.7-1.11.31.3-1.2-1.0-0.60.60.5-0.5-0.6-0.2-0.3
Total zone transitions, hab. session 10.20.21.0-0.10.50.7-0.7-0.4-0.30.20.2-0.6-1.0-0.3-0.2
Total locomotion distance, hab. session 10.00.00.1-0.10.20.2-0.2-0.10.1-0.1-0.1-0.3-0.4-0.3-0.0
Locomotion velocity, hab. session 10.20.30.60.6-0.6-0.60.60.60.7-0.7-0.70.30.40.40.6
Time in familiar zone, hab. session 20.20.20.60.8-0.7-0.70.60.40.0-0.1-0.00.30.2-0.5-0.2
Time in novel zone, hab. session 20.20.31.1-1.00.80.6-0.6-0.5-0.20.30.2-0.3-0.30.30.0
Total zone transitions, hab. session 20.10.10.40.6-0.10.3-0.2-0.1-0.10.00.2-0.5-0.5-0.3-0.2
Total locomotion distance, hab. session 20.40.60.90.8-0.8-0.70.80.80.9-0.9-0.80.40.70.40.7
Locomotion velocity, hab. session 20.50.61.01.0-0.9-0.70.80.80.9-1.0-0.80.40.80.50.7
Novel to familiar place preference ratio1.11.53.2-1.61.71.5-1.5-1.1-0.70.80.8-1.0-1.8-0.6-0.6
Novelty place preference1.41.83.5-1.71.81.6-1.6-1.4-0.91.01.0-1.1-1.9-0.8-0.8
Time in novel zone, NPP test1.61.93.9-1.71.81.6-1.6-1.4-1.01.11.0-1.2-2.0-0.8-0.8
Total zone transitions, NPP test0.71.12.61.6-1.4-0.91.00.90.8-0.9-0.90.90.81.10.9
Total locomotion distance, NPP test0.91.21.91.2-1.4-1.11.31.11.1-1.2-1.10.90.61.21.1
Locomotion velocity, NPP test1.72.53.61.7-1.9-1.61.71.61.5-1.7-1.61.41.21.41.5
Intraocular pressure3.86.28.5-2.02.32.5-2.5-2.6-2.92.72.7-2.6-2.4-1.9-2.5
Delta distance traveled before/after self-admin1.11.22.2-1.51.41.1-1.1-0.9-1.01.11.0-0.7-0.5-1.4-1.1
Delta ambulatory time before/after self-admin0.30.61.0-0.91.00.9-0.9-0.7-0.70.80.6-0.4-0.1-1.0-0.8
Parametrial fat weight1.53.611.2-3.32.92.1-2.1-1.8-1.51.51.2-0.9-1.1-1.5-1.2
Pavlov. Cond. lever latency0.60.72.9-1.71.30.9-0.9-0.7-0.50.50.6-0.5-0.6-0.5-0.4
Pavlov. Cond. magazine entry latency1.01.32.30.9-1.4-1.51.51.11.0-1.0-1.10.90.71.10.9
Pavlov. Cond. change in total contacts0.50.51.50.7-1.2-1.21.20.80.4-0.4-0.50.20.40.50.2
Pavlov. Cond. index score0.60.81.81.3-1.3-1.21.20.80.7-0.6-0.70.50.50.70.5
Pavlov. Cond. latency score0.50.71.51.2-1.2-1.11.10.80.6-0.6-0.70.50.40.60.5
Pavlov. Cond. lever contacts0.60.82.41.6-1.3-0.90.90.70.6-0.6-0.70.60.70.70.6
Pavlov. Cond. magazine entry number0.60.71.8-0.71.21.3-1.3-1.0-0.70.70.8-0.5-0.3-0.6-0.5
Pavlov. Cond. intertrial magazine entries0.50.61.00.40.40.9-0.8-0.9-0.90.91.0-0.9-0.5-0.7-0.9
Pavlov. Cond. lever-magazine prob. diff.1.11.32.81.6-1.7-1.51.51.10.9-0.9-1.00.70.61.00.7
Pavlov. Cond. response bias0.60.71.91.4-1.4-1.21.20.80.6-0.5-0.60.40.40.50.4
Pavlov. Cond. lever latency0.30.40.8-0.90.80.5-0.5-0.5-0.50.50.5-0.4-0.4-0.9-0.5
Pavlov. Cond. magazine entry latency0.10.20.40.20.10.2-0.20.20.4-0.5-0.60.60.60.40.6
Pavlov. Cond. change in total contacts0.00.10.70.4-0.20.1-0.1-0.10.3-0.2-0.10.10.00.80.4
Pavlov. Cond. index score0.10.10.30.4-0.2-0.00.00.20.4-0.4-0.40.40.30.60.5
Pavlov. Cond. latency score0.10.20.30.5-0.3-0.00.10.30.4-0.5-0.50.50.40.60.5
Pavlov. Cond. lever contacts0.10.10.60.6-0.4-0.10.10.20.2-0.2-0.20.30.30.80.4
Pavlov. Cond. magazine entry number0.30.30.7-0.3-0.1-0.20.2-0.3-0.60.60.8-0.8-0.7-0.8-0.8
Pavlov. Cond. intertrial magazine entries0.81.74.1-2.01.20.6-0.6-1.0-1.21.21.3-1.3-1.4-1.6-1.4
Pavlov. Cond. lever-magazine prob. diff.0.00.00.10.10.10.3-0.3-0.10.0-0.1-0.10.1-0.00.20.1
Pavlov. Cond. response bias0.30.41.00.9-0.5-0.10.10.40.5-0.5-0.60.70.71.00.7
Time in closed arm before self-admin0.20.31.5-1.20.50.0-0.0-0.3-0.40.40.60.20.4-0.5-0.3
Time in closed arm after self-admin0.30.32.2-1.50.70.1-0.1-0.2-0.20.10.3-0.6-0.6-0.4-0.3
Time in open arm before self-admin0.50.61.2-0.10.71.1-1.1-0.8-0.70.60.6-1.1-1.1-0.2-0.5
Time in open arm after self-admin2.22.44.62.1-1.8-1.41.41.51.3-1.3-1.61.61.61.41.4
Bone: periosteal estimation1.02.33.61.9-1.9-1.71.71.41.4-1.3-1.41.41.31.21.3
Bone: periosteal perimeter1.12.22.91.5-1.7-1.71.71.41.3-1.4-1.41.41.31.41.4
Bone: post-yield work1.22.22.51.4-1.5-1.61.51.51.5-1.6-1.61.51.31.11.5
Progressive ratio test 1 active lever presses0.10.20.40.4-0.4-0.50.40.60.3-0.5-0.20.50.7-0.30.3
Progressive ratio test 1 breakpoint0.10.20.50.5-0.4-0.50.50.60.4-0.5-0.30.60.7-0.30.4
Progressive ratio test 1 inactive lever presses0.82.03.51.1-1.3-1.61.51.71.9-1.5-1.31.21.50.51.4
Progressive ratio test 2 active lever presses0.20.30.7-0.00.10.3-0.3-0.5-0.80.70.7-0.7-0.3-0.8-0.8
Progressive ratio test 2 breakpoint0.30.40.8-0.10.10.3-0.3-0.5-0.80.70.8-0.7-0.3-0.9-0.8
Progressive ratio test 2 inactive lever presses0.20.51.6-0.30.30.3-0.3-0.7-0.60.80.8-0.8-0.6-1.3-0.9
Incentive Sensitization - Responses0.31.02.1-0.30.20.4-0.4-0.9-1.51.31.2-1.1-0.9-1.0-1.4
Incentive Sensitization - Breakpoint0.40.92.0-0.40.20.5-0.4-0.9-1.41.21.2-1.0-0.8-1.0-1.4
Sum of active levers in priming session hrs 5-60.90.82.31.5-1.3-1.11.11.20.8-0.8-0.80.40.00.30.4
Progressive ratio0.10.21.2-1.10.60.2-0.1-0.3-0.20.00.1-0.00.1-0.5-0.1
Food seeking constrained by brief footshock0.10.11.11.0-0.4-0.20.20.20.0-0.1-0.00.10.1-0.2-0.2
Seeking ratio, punishment vs. effort0.20.51.00.70.10.5-0.7-0.6-0.80.80.8-0.9-1.0-0.3-0.8
Retroperitoneal fat weight3.616.352.8-7.36.14.6-4.6-4.0-2.92.92.6-2.5-2.4-2.7-2.3
Reaction time number correct0.00.10.20.30.00.2-0.2-0.2-0.30.40.4-0.5-0.5-0.4-0.5
Reaction time mean minus median0.00.21.00.30.30.5-0.5-0.4-0.30.30.10.20.1-1.0-0.3
Reaction time mean minus median AUC0.21.12.5-0.30.91.1-1.1-1.1-1.11.21.0-0.6-0.9-1.6-1.2
Reaction time num false alarms0.20.41.81.0-0.9-0.50.50.3-0.1-0.1-0.0-0.1-0.31.30.2
Reaction time num false alarms AUC0.30.83.11.2-1.3-0.91.00.70.3-0.5-0.40.30.11.80.6
Reaction time trials correct on left0.00.10.20.30.00.2-0.2-0.2-0.30.40.4-0.5-0.5-0.4-0.5
Reaction time trials on left0.00.10.30.3-0.00.2-0.2-0.2-0.30.40.4-0.5-0.5-0.4-0.5
Reaction time mean0.40.91.9-0.50.60.6-0.7-0.9-1.21.01.0-0.8-1.0-1.4-1.2
Reaction time mean AUC0.30.71.4-0.40.50.5-0.5-0.8-1.10.90.9-0.6-0.8-1.2-1.1
Median of all reaction times0.71.12.1-0.70.60.6-0.6-0.9-1.41.11.1-1.2-1.3-1.4-1.4
Reaction time omissions0.20.40.70.00.30.5-0.6-0.9-0.80.80.8-0.4-0.6-0.6-0.7
Reaction time false alarm rate0.81.13.50.9-1.3-1.11.10.90.6-0.9-0.80.70.51.91.0
Reaction time premature initiation rate0.30.41.00.1-0.2-0.10.10.40.8-0.6-0.60.80.91.01.0
Reaction time premature initiations0.00.10.30.2-0.10.0-0.10.10.4-0.2-0.20.30.40.60.5
Std. dev. reaction times0.20.71.8-0.40.80.9-0.9-0.9-0.90.80.7-0.4-0.6-1.3-0.9
Reaction time trials completed0.00.10.30.3-0.00.2-0.2-0.2-0.30.40.4-0.5-0.5-0.4-0.5
Reaction time trials AUC0.00.10.30.4-0.00.1-0.2-0.2-0.30.40.4-0.5-0.5-0.5-0.5
Run reversals in cocaine runway, females0.10.10.2-0.20.0-0.20.20.40.4-0.5-0.30.30.20.10.4
Run reversals in cocaine runway, males0.10.10.70.1-0.3-0.20.20.30.3-0.3-0.40.4-0.00.90.5
Latency to leave start box in cocaine runway0.20.30.60.7-0.6-0.40.40.70.5-0.6-0.60.50.60.30.4
Latency to leave start box in cocaine runway, F0.60.71.21.0-0.9-0.60.60.90.7-0.8-0.80.81.10.90.7
Latency to leave start box in cocaine runway, M0.40.41.0-0.50.60.6-0.6-0.4-0.40.50.5-0.7-1.0-0.8-0.6
Std. dev. time between licks in bursts0.00.10.2-0.40.30.3-0.3-0.1-0.00.1-0.00.0-0.10.40.2
Total sessions with >9 infusions0.40.51.5-0.60.40.1-0.2-0.3-0.60.50.8-0.9-1.0-1.2-0.8
Short access day 1 total inactive lever presses0.91.93.41.3-1.6-1.81.81.41.4-1.2-1.01.21.70.31.0
Short access day 10 total inactive lever presses0.10.71.91.0-0.9-1.01.00.91.4-0.7-0.50.80.4-0.30.6
Short access day 1 total infusions0.10.10.30.3-0.4-0.50.50.2-0.0-0.00.2-0.4-0.5-0.5-0.2
Short access day 10 total infusions0.30.51.10.9-1.0-1.11.00.80.5-0.5-0.10.40.2-0.20.2
Short access total infusions0.10.21.1-0.00.0-0.20.1-0.0-0.30.20.5-0.5-0.5-1.1-0.5
Short access day 1 locomotion0.40.71.60.8-1.0-1.31.21.20.9-0.9-0.70.50.2-0.10.6
Short access day 10 total locomotion0.52.13.61.0-1.0-1.11.21.31.4-1.7-1.81.91.91.11.7
Short access total locomotion0.10.10.7-0.70.50.2-0.2-0.2-0.1-0.10.00.10.0-0.9-0.1
One hour access (0.3 mA shock)0.70.81.90.2-0.10.3-0.3-0.4-1.10.91.0-1.4-1.0-1.3-1.3
Compulsive drug intake1.62.44.0-0.91.11.1-1.1-1.3-1.92.01.8-1.6-1.4-1.6-2.0
One hour access (shock baseline)0.10.20.50.7-0.7-0.50.50.40.1-0.4-0.2-0.3-0.10.00.0
Social response proportion0.10.20.3-0.20.60.6-0.6-0.10.3-0.2-0.20.50.60.20.5
Social responses3.44.57.00.7-1.6-2.12.22.22.7-2.4-2.52.22.11.72.4
Social time0.10.20.7-0.30.60.6-0.5-0.30.10.10.1-0.20.1-0.9-0.2
Soleus weight4.713.919.94.0-4.5-4.14.13.83.4-3.4-3.53.23.13.93.3
Bone: stiffness0.10.30.70.5-0.7-0.80.70.50.4-0.4-0.30.30.20.40.3
Tibialis anterior weight3.110.815.63.9-3.6-3.13.23.33.4-3.3-3.23.12.93.13.2
Time to tail flick, vehicle, before self-admin1.11.42.2-1.51.41.1-1.1-1.3-0.81.11.1-1.5-1.4-0.9-0.9
Time to tail flick, vehicle, after self-admin0.00.10.2-0.30.40.2-0.20.10.5-0.3-0.2-0.4-0.2-0.30.0
Time to tail flick, test, before self-admin0.10.21.0-0.20.30.2-0.1-0.0-0.10.20.3-1.0-0.6-0.4-0.5
Time to tail flick, test, after self-admin2.22.33.40.9-1.5-1.81.81.61.8-1.7-1.70.81.21.51.4
Delta time to tail flick, vehicle, before/after SA0.91.01.41.2-0.8-0.80.81.01.0-1.2-1.11.20.80.71.0
Delta time to tail flick, test, before/after SA2.73.33.81.7-1.9-1.91.91.71.9-1.8-1.91.91.71.81.8
Tibia length0.10.32.3-1.50.6-0.10.0-0.00.2-0.1-0.20.20.4-0.30.1
Ambulatory time before self-admin0.61.72.80.7-1.3-1.51.51.51.4-1.4-1.40.90.91.71.3
Ambulatory time after self-admin0.10.10.5-0.70.1-0.20.10.40.3-0.2-0.4-0.00.30.50.2
Bone: tissue strength0.60.70.8-0.80.80.8-0.8-0.8-0.80.80.9-0.9-0.9-0.8-0.8
Total heroin consumption1.21.42.71.7-1.5-1.41.41.51.1-1.2-1.10.80.60.40.8
Bone: trabecular number0.20.33.21.8-0.7-0.20.1-0.00.10.0-0.00.0-0.0-0.5-0.2
Bone: trabecular spacing0.10.10.5-0.7-0.0-0.30.40.4-0.1-0.1-0.00.10.10.40.0
Bone: trabecular thickness0.10.21.01.0-0.6-0.50.40.20.4-0.2-0.1-0.10.1-0.10.1
Bone: trabecular tissue density0.10.20.30.3-0.3-0.30.40.50.6-0.5-0.50.30.40.00.3
Water consumed over 24 hours0.61.11.91.4-1.4-1.21.21.10.9-0.9-1.00.80.70.70.7
Number of responses in last shaping day0.50.71.8-0.90.60.4-0.5-0.7-0.40.91.0-1.3-1.2-0.5-0.7