Hub : Genes

Kcnk3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Kcnk3	0.06	0.05	3.5e-06	0.04	0.04	0.03	0.04	4.8e-05	3.5e-05	3.8e-04	6.7e-05
2	IC	gene expression	Kcnk3	0.05	0.05	8.8e-03	0.03	0.04	0.04	0.03	1.7e-02	8.5e-03	1.1e-02	1.4e-02
3	Liver	gene expression	Kcnk3	0.03	0.03	5.9e-03	0.02	0.01	0.02	0.01	5.4e-03	9.9e-03	5.8e-03	8.1e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	2.4	4.2	4.9	-2.2	-2.1	1.9
Area under the delay curve	0.0	0.0	0.0	-0.0	-0.0	-0.2
BMI with tail	1.7	5.8	6.7	2.2	2.4	-2.6
BMI without tail	1.8	5.6	5.9	2.3	2.4	-2.4
Body weight	2.4	10.6	11.1	3.3	3.3	-3.1
Weight adjusted by age	0.0	0.1	0.2	0.0	0.1	-0.4
Bone surface	0.4	0.8	1.1	-1.1	-0.9	0.7
Bone volume	1.1	2.0	2.2	-1.5	-1.4	1.3
Breakpoint value in progressive ratio session	0.6	0.7	0.9	-1.0	-0.9	0.6
Number of licking bursts	0.8	1.3	1.7	1.0	1.1	-1.3
Context. condit. distance diff. score	0.2	0.3	0.3	-0.4	-0.5	0.6
Locomotion velocity, session 1	0.6	0.6	0.7	0.7	0.8	-0.9
Locomotion distance, session 1	0.4	0.5	0.6	-0.8	-0.7	0.7
Locomotion velocity, session 2	0.1	0.1	0.1	0.3	0.3	-0.1
Locomotion distance, session 2	0.1	0.1	0.1	0.3	0.3	-0.3
Locomotion velocity, session 3	0.1	0.1	0.3	-0.5	-0.4	0.1
Locomotion distance, session 3	0.0	0.0	0.1	-0.1	0.0	-0.3
Stereotopy head waving bouts, day 3	2.3	2.7	2.9	-1.7	-1.7	1.6
Stereotopy head waving duration, day 3	0.6	0.7	0.7	-0.8	-0.8	0.9
Locomotion velocity, session 7	0.0	0.0	0.1	-0.3	-0.1	-0.1
Locomotion distance, session 7	0.7	0.9	1.3	0.8	0.9	-1.1
Stereotopy head waving bouts, day 7	0.0	0.0	0.0	0.1	0.0	-0.0
Stereotopy head waving duration, day 7	0.4	0.5	0.6	-0.8	-0.8	0.7
Locomotion velocity, session 8	0.4	0.5	0.6	-0.8	-0.8	0.7
Locomotion distance, session 8	0.2	0.3	0.4	-0.6	-0.6	0.6
Degree of sensitization distance	1.0	1.0	1.1	1.0	1.0	-0.9
Degree of sensitization stereotypy	0.3	0.3	0.3	0.6	0.5	-0.5
Conditioned locomotion	3.2	3.7	4.2	-2.0	-2.0	1.7
Cocaine response after cond. corrected	0.2	0.2	0.2	-0.5	-0.4	0.4
Cocaine response after cond. not corrected	0.8	0.9	1.0	-1.0	-1.0	0.9
Cocaine response before conditioning	2.8	3.3	3.4	-1.8	-1.8	1.8
Saline control response	1.1	1.5	1.5	-1.2	-1.2	1.2
Bone: connectivity density	1.6	2.5	3.2	-1.8	-1.6	1.3
Bone: cortical apparent density	0.1	0.1	0.1	-0.3	-0.3	0.1
Bone: cortical area	0.0	0.0	0.0	-0.1	0.1	-0.1
Bone: cortical porosity	2.9	3.1	3.3	-1.7	-1.8	1.8
Bone: cortical porosity	2.6	2.8	2.9	-1.6	-1.7	1.7
Bone: cortical thickness	0.2	0.4	0.4	0.6	0.6	-0.7
Bone: cortical thickness	0.4	0.4	0.6	-0.7	-0.6	0.6
Bone: cortical tissue density	0.0	0.0	0.1	-0.2	-0.2	0.1
Condit. Reinf. active minus inactive responses	1.8	2.1	2.2	1.4	1.4	-1.5
Condit. Reinf. active-inactive response ratio	1.5	1.7	1.8	1.2	1.3	-1.3
Condit. Reinf. active responses	0.1	0.1	0.2	0.2	0.3	-0.4
Condit. Reinf. inactive responses	1.0	1.2	1.3	-1.1	-1.1	1.0
Incentive salience index mean	0.2	0.2	0.3	0.4	0.5	-0.5
Condit. Reinf. lever presses	0.7	1.0	1.0	-1.0	-1.0	1.0
Condit. Reinf. active minus inactive responses	1.5	1.9	2.5	-1.6	-1.5	1.0
Condit. Reinf. active-inactive response ratio	0.6	0.7	0.8	-0.9	-0.9	0.6
Condit. Reinf. active responses	0.9	1.3	1.9	-1.4	-1.2	0.8
Condit. Reinf. inactive responses	0.3	0.4	0.6	-0.8	-0.6	0.4
Condit. Reinf. lever presses	1.3	1.8	2.0	-1.4	-1.4	1.2
Condit. Reinf. lever reinforcers received	0.9	1.2	1.8	-1.3	-1.2	0.7
Conditioned reinforcement - actives	4.3	7.3	8.0	-2.6	-2.7	2.8
Conditioned reinforcement - inactives	4.5	6.7	7.2	-2.5	-2.5	2.7
Conditioned locomotion	1.8	2.4	2.7	-1.4	-1.5	1.7
Patch foraging indifference point 0 sec	0.6	1.0	1.1	1.0	1.1	-0.9
Patch foraging indifference point AUC	0.0	0.0	0.1	-0.2	-0.1	-0.2
Delay disc. indifference point, 0s delay	1.5	1.6	2.0	1.4	1.3	-1.1
Delay disc. indifference point, 16s delay	0.0	0.0	0.1	0.1	0.1	-0.4
Delay disc. indifference point, 2s delay	0.2	0.2	0.2	0.4	0.4	-0.5
Delay disc. indifference point, 24s delay	1.7	1.9	2.1	-1.3	-1.4	1.4
Delay disc. indifference point, 4s delay	0.1	0.1	0.2	0.3	0.3	-0.5
Delay disc. indifference point, 8s delay	0.0	0.0	0.0	-0.1	-0.1	0.1
Indifference point function ln k	1.0	1.7	2.2	-1.1	-1.3	1.5
Indifference point function log k	1.0	1.7	2.2	-1.1	-1.3	1.5
Patch foraging total patch changes 0 sec	0.6	1.1	1.2	1.1	1.1	-1.0
Patch foraging total patch changes 12 sec	1.4	1.9	1.9	1.3	1.4	-1.4
Patch foraging total patch changes 18 sec	1.0	1.6	2.1	1.1	1.2	-1.5
Patch foraging total patch changes 24 sec	1.2	2.1	2.3	1.4	1.4	-1.5
Patch foraging total patch changes 6 sec	1.8	2.7	3.4	1.4	1.6	-1.9
Patch foraging time to switch 0 sec	0.2	0.3	0.5	0.5	0.6	-0.7
Patch foraging water rate 0 sec	0.6	1.2	1.6	-0.9	-1.1	1.2
Patch foraging water rate 12 sec	0.1	0.2	0.3	0.6	0.4	-0.3
Patch foraging water rate 18 sec	0.5	0.8	1.2	-0.6	-0.8	1.1
Patch foraging water rate 24 sec	0.3	0.4	0.6	0.8	0.6	-0.5
Patch foraging water rate 6 sec	0.1	0.1	0.2	0.1	-0.1	0.4
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.1	0.2	0.3	-0.3
Distance traveled before self-admin	0.1	0.1	0.2	-0.2	-0.3	0.4
Distance traveled after self-admin	1.3	1.6	1.9	1.4	1.3	-1.1
Extensor digitorum longus weight	2.6	10.3	12.3	-3.5	-3.3	2.7
Bone: elastic displacement	1.5	1.8	1.8	-1.3	-1.3	1.4
Bone: elastic work	0.6	0.8	0.9	-0.9	-0.9	0.8
Bone: endosteal estimation	0.1	0.3	0.4	-0.6	-0.5	0.6
Bone: endosteal perimeter	0.0	0.0	0.1	-0.2	-0.1	0.1
Epididymis fat weight	17.0	58.2	60.8	7.8	7.7	-7.4
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	0.3	0.3	-0.2
Delta time in open arm before/after self-admin	0.0	0.0	0.0	-0.2	-0.1	-0.1
Diff in mean of infusions in LGA sessions	0.0	0.1	0.1	0.2	0.2	-0.3
Delay discount exponential model param	0.1	0.1	0.1	0.3	0.3	-0.1
Extinction: sum of active levers before priming	0.5	0.5	0.6	-0.7	-0.7	0.8
Active lever presses in extinction session 6	1.7	1.7	1.8	-1.3	-1.3	1.2
Bone: final force	0.0	0.0	0.0	0.0	0.1	-0.1
Bone: final moment	0.0	0.0	0.0	0.0	0.1	-0.1
Food consumed during 24 hour testing period	0.0	0.1	0.1	0.1	0.2	-0.3
Glucose	0.8	1.2	1.3	1.0	1.1	-1.1
Heart weight	1.6	2.4	3.0	1.7	1.6	-1.3
Delay discount hyperbolic model param	0.0	0.0	0.0	0.1	0.1	0.1
Intermittent access intake day 1-15 change	0.5	1.0	1.4	-0.8	-0.9	1.2
Intermittent access intake escalation	0.2	0.4	0.7	-0.5	-0.6	0.8
Intermittent access intake escalation 2	0.0	0.0	0.0	-0.1	-0.1	0.1
Intermitt. access day 1 inactive lever presses	0.4	1.6	1.6	-1.3	-1.3	1.3
Intermitt. access day 15 inactive lever presses	1.2	2.5	3.1	-1.8	-1.6	1.4
Intermitt. access escalation Index	3.5	5.0	5.5	2.1	2.3	-2.4
Intermittent access day 1 total infusions	3.1	5.0	5.3	-2.3	-2.2	2.1
Intermittent access day 15 total infusions	2.7	4.0	4.6	-1.9	-1.9	2.2
Intermittent access terminal intake (last 3 days)	3.8	5.0	5.3	-2.2	-2.2	2.3
Intermittent access total infusions	5.1	6.1	6.7	-2.4	-2.4	2.6
Intermittent access day 1 locomotion	2.6	3.3	3.3	-1.8	-1.8	1.8
Intermittent access day 15 total locomotion	0.2	0.3	0.3	-0.5	-0.5	0.6
Intermittent access total locomotion	1.5	1.8	2.2	-1.3	-1.3	1.5
Intermittent access standard deviation	1.2	2.4	2.5	-1.5	-1.5	1.6
Left kidney weight	0.1	0.5	0.9	-0.5	-0.6	1.0
Right kidney weight	0.1	0.3	0.6	0.8	0.6	-0.2
Cocaine induced anxiety	0.1	0.1	0.1	-0.3	-0.2	0.3
Post-drug Anxiety	1.7	1.8	1.9	1.4	1.4	-1.2
Baseline Anxiety	3.8	4.4	4.4	2.1	2.1	-2.1
Tail length	0.0	0.1	0.2	0.4	0.3	0.1
Length with tail	0.3	1.1	1.9	1.4	1.1	-0.5
Length without tail	0.1	0.2	0.3	0.6	0.4	-0.2
Times rat made contact with spout	0.7	0.8	1.0	-1.0	-0.9	0.7
Lifetime Intake	5.7	6.9	7.7	-2.5	-2.6	2.8
Liver weight, left	2.4	3.9	4.5	2.1	2.0	-1.8
Liver weight, right	4.3	7.5	9.5	3.1	2.8	-2.3
Locomotor activity	0.5	0.8	0.9	0.9	1.0	-0.8
Locomotor testing distance	0.1	0.2	0.4	0.3	0.5	-0.6
Locomotor testing rearing	0.3	0.7	0.9	-1.0	-0.8	0.7
Locomotion in novel chamber	0.0	0.0	0.0	0.2	0.2	-0.2
Locomotion in novel chamber post-restriction	2.6	4.2	4.4	2.1	2.1	-2.0
Fecal boli incidents, locomotor time 1	1.6	2.3	3.0	-1.3	-1.5	1.7
Change in fecal boli incidents, locomotor task	4.2	4.1	4.3	2.1	2.0	-2.0
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.4	-0.4	-0.5	0.7
Bouts of movement, locomotor time 1	0.1	0.1	0.1	-0.4	-0.2	-0.2
Total resting periods, locomotor time 1	0.1	0.1	0.2	-0.4	-0.2	-0.2
Rest time, locomotor task time 1	0.2	0.2	0.3	0.4	0.4	-0.6
Distance moved, locomotor task time 1	0.1	0.2	0.3	0.6	0.5	-0.2
Vertical activity count, locomotor time 1	0.0	0.1	0.2	0.4	0.3	-0.2
Time >=10cm from walls, locomotor time 2	1.1	1.6	1.8	-1.2	-1.3	1.3
Bouts of movement, locomotor time 2	0.3	0.5	0.6	0.7	0.7	-0.7
Total resting periods, locomotor time 2	0.2	0.4	0.6	0.6	0.6	-0.8
Rest time, locomotor task time 2	0.0	0.1	0.1	-0.4	-0.2	0.0
Distance moved, locomotor task time 2	0.0	0.0	0.1	0.3	0.2	-0.1
Vertical activity count, locomotor time 2	0.0	0.0	0.1	-0.0	-0.2	0.3
Light reinforcement 1	0.6	1.4	1.9	-1.4	-1.2	1.0
Light reinforcement 2	1.0	1.5	1.8	-1.4	-1.3	1.0
Bone: marrow area	0.1	0.3	0.4	-0.6	-0.5	0.5
Bone: maximum diameter	0.0	0.1	0.1	-0.4	-0.2	0.1
Bone: maximum force	0.0	0.0	0.0	-0.2	-0.1	0.2
Bone: maximum moment	0.0	0.0	0.1	-0.2	-0.2	0.2
Mean time between licks in bursts	1.0	2.4	2.9	1.7	1.6	-1.3
Mean num. licks in bursts	1.0	1.6	1.9	-1.2	-1.3	1.4
Cd content in liver	0.0	0.0	0.0	0.1	0.1	-0.0
Co content in liver	5.9	6.9	7.1	-2.6	-2.6	2.7
Cu content in liver	0.4	0.5	0.5	-0.6	-0.7	0.7
Fe content in liver	2.0	2.4	2.5	-1.6	-1.5	1.6
K content in liver	0.1	0.1	0.1	0.2	0.3	-0.2
Mg content in liver	0.0	0.0	0.1	-0.0	0.1	0.3
Mn content in liver	0.5	0.5	0.7	0.6	0.8	-0.7
Na content in liver	2.0	2.2	2.6	-1.4	-1.4	1.6
Rb content in liver	0.1	0.1	0.1	0.2	0.3	-0.2
Se content in liver	0.1	0.1	0.1	0.3	0.4	-0.2
Sr content in liver	0.1	0.0	0.1	-0.1	-0.2	0.3
Zn content in liver	0.5	0.6	0.8	0.9	0.9	-0.5
Bone: minimum diameter	0.4	0.7	0.9	0.8	0.9	-0.8
Time in familiar zone, hab. session 1	0.9	0.8	0.9	0.9	0.9	-0.9
Time in novel zone, hab. session 1	0.2	0.2	0.2	0.5	0.5	-0.4
Total zone transitions, hab. session 1	0.1	0.2	0.2	-0.4	-0.4	0.3
Total locomotion distance, hab. session 1	0.5	0.7	0.9	-0.8	-0.8	0.9
Locomotion velocity, hab. session 1	1.2	1.7	1.7	-1.3	-1.3	1.3
Time in familiar zone, hab. session 2	0.3	0.3	0.4	0.4	0.5	-0.7
Time in novel zone, hab. session 2	0.0	0.0	0.1	0.3	0.2	0.0
Total zone transitions, hab. session 2	0.1	0.2	0.3	0.3	0.4	-0.5
Total locomotion distance, hab. session 2	0.2	0.2	0.3	0.3	0.4	-0.6
Locomotion velocity, hab. session 2	0.1	0.1	0.2	0.1	0.2	-0.4
Novel to familiar place preference ratio	0.6	0.6	0.8	0.9	0.8	-0.6
Novelty place preference	1.0	1.0	1.3	1.1	1.1	-0.8
Time in novel zone, NPP test	0.9	1.0	1.3	1.1	1.1	-0.8
Total zone transitions, NPP test	1.0	1.4	1.5	-1.2	-1.2	1.1
Total locomotion distance, NPP test	1.3	1.8	2.0	-1.4	-1.4	1.2
Locomotion velocity, NPP test	1.8	2.6	2.9	-1.7	-1.6	1.5
Intraocular pressure	5.2	7.5	8.0	2.8	2.8	-2.6
Delta distance traveled before/after self-admin	2.8	2.9	3.1	1.7	1.7	-1.8
Delta ambulatory time before/after self-admin	0.7	0.8	0.9	0.9	0.9	-0.9
Parametrial fat weight	18.9	44.4	44.9	6.7	6.6	-6.7
Pavlov. Cond. lever latency	0.6	0.7	0.9	0.9	0.8	-0.7
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	0.1	0.1	-0.2
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	-0.2	-0.2	0.3
Pavlov. Cond. index score	0.1	0.1	0.1	-0.4	-0.3	0.2
Pavlov. Cond. latency score	0.0	0.0	0.1	-0.3	-0.2	0.1
Pavlov. Cond. lever contacts	0.5	0.6	0.7	-0.8	-0.7	0.7
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	0.2	0.2	-0.1
Pavlov. Cond. intertrial magazine entries	2.1	2.6	2.6	-1.6	-1.6	1.6
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	0.6	-0.8	-0.7	0.6
Pavlov. Cond. response bias	0.7	0.9	1.0	-1.0	-0.9	0.9
Pavlov. Cond. lever latency	0.7	1.0	1.2	1.1	1.1	-0.8
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	-0.0	0.0	-0.3
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	-0.5	-0.4	0.0
Pavlov. Cond. index score	0.3	0.5	0.7	-0.8	-0.7	0.4
Pavlov. Cond. latency score	0.4	0.5	0.7	-0.8	-0.8	0.5
Pavlov. Cond. lever contacts	0.5	0.6	0.8	-0.9	-0.8	0.7
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	-0.1	-0.2	0.5
Pavlov. Cond. intertrial magazine entries	2.5	3.8	4.3	2.1	2.0	-1.7
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	-0.5	-0.4	0.1
Pavlov. Cond. response bias	0.6	0.9	1.1	-1.1	-1.0	0.7
Time in closed arm before self-admin	0.4	0.5	0.5	0.7	0.7	-0.7
Time in closed arm after self-admin	1.1	1.2	1.4	1.0	1.0	-1.2
Time in open arm before self-admin	0.0	0.0	0.0	-0.0	-0.0	0.1
Time in open arm after self-admin	0.4	0.5	0.6	-0.8	-0.7	0.6
Bone: periosteal estimation	0.2	0.4	0.5	-0.7	-0.5	0.6
Bone: periosteal perimeter	0.0	0.0	0.1	-0.2	-0.1	0.2
Bone: post-yield work	1.9	2.8	3.2	-1.6	-1.7	1.8
Progressive ratio test 1 active lever presses	3.5	4.3	5.0	-2.0	-2.0	2.2
Progressive ratio test 1 breakpoint	3.6	4.4	5.2	-2.0	-2.0	2.3
Progressive ratio test 1 inactive lever presses	5.2	7.5	8.2	-2.7	-2.7	2.9
Progressive ratio test 2 active lever presses	3.0	3.5	4.3	-1.7	-1.8	2.1
Progressive ratio test 2 breakpoint	2.8	3.2	4.0	-1.6	-1.7	2.0
Progressive ratio test 2 inactive lever presses	2.9	4.7	5.2	-2.1	-2.1	2.3
Incentive Sensitization - Responses	1.4	1.9	2.2	-1.3	-1.4	1.5
Incentive Sensitization - Breakpoint	1.1	1.4	1.6	-1.1	-1.2	1.3
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.4	0.2	0.4	-0.6
Progressive ratio	0.0	0.0	0.0	0.2	0.2	-0.2
Food seeking constrained by brief footshock	12.1	14.8	16.6	-3.7	-3.8	4.1
Seeking ratio, punishment vs. effort	1.4	2.0	2.1	-1.3	-1.4	1.5
Retroperitoneal fat weight	33.4	142.4	143.8	11.8	12.0	-12.0
Reaction time number correct	0.1	0.3	0.4	-0.6	-0.6	0.4
Reaction time mean minus median	0.0	0.0	0.0	-0.1	-0.1	-0.0
Reaction time mean minus median AUC	0.0	0.1	0.1	0.3	0.3	-0.3
Reaction time num false alarms	1.4	1.9	2.1	1.3	1.5	-1.5
Reaction time num false alarms AUC	1.3	2.1	2.3	1.3	1.5	-1.4
Reaction time trials correct on left	0.1	0.3	0.4	-0.6	-0.6	0.4
Reaction time trials on left	0.1	0.3	0.4	-0.6	-0.6	0.4
Reaction time mean	0.1	0.2	0.4	0.6	0.4	-0.1
Reaction time mean AUC	0.1	0.1	0.3	0.5	0.3	-0.0
Median of all reaction times	0.1	0.2	0.4	0.6	0.4	0.0
Reaction time omissions	0.1	0.1	0.2	0.2	0.3	-0.4
Reaction time false alarm rate	1.9	2.6	2.9	1.6	1.7	-1.6
Reaction time premature initiation rate	0.1	0.1	0.2	0.4	0.4	-0.3
Reaction time premature initiations	0.0	0.0	0.0	0.1	0.1	-0.1
Std. dev. reaction times	0.1	0.2	0.3	0.5	0.5	-0.4
Reaction time trials completed	0.1	0.3	0.4	-0.6	-0.6	0.4
Reaction time trials AUC	0.2	0.4	0.5	-0.7	-0.6	0.4
Run reversals in cocaine runway, females	0.3	0.3	0.4	-0.5	-0.6	0.7
Run reversals in cocaine runway, males	0.7	0.7	0.8	-0.8	-0.9	0.9
Latency to leave start box in cocaine runway	0.7	0.8	0.8	-0.9	-0.9	0.9
Latency to leave start box in cocaine runway, F	0.1	0.1	0.1	-0.4	-0.4	0.3
Latency to leave start box in cocaine runway, M	0.7	0.7	0.7	-0.8	-0.8	0.9
Std. dev. time between licks in bursts	0.9	1.2	1.2	1.0	1.1	-1.1
Total sessions with >9 infusions	3.1	3.7	4.5	-1.8	-1.9	2.1
Short access day 1 total inactive lever presses	6.2	8.2	8.7	-2.9	-2.8	2.8
Short access day 10 total inactive lever presses	0.7	1.7	2.1	-1.5	-1.3	1.0
Short access day 1 total infusions	5.1	6.7	7.0	-2.6	-2.6	2.6
Short access day 10 total infusions	4.7	6.1	6.6	-2.4	-2.4	2.6
Short access total infusions	3.3	4.2	4.8	-2.0	-2.0	2.2
Short access day 1 locomotion	3.5	4.3	4.6	-2.1	-2.1	2.0
Short access day 10 total locomotion	1.3	2.4	2.5	-1.6	-1.6	1.5
Short access total locomotion	1.3	1.5	1.8	-1.1	-1.2	1.3
One hour access (0.3 mA shock)	3.3	3.8	4.3	-1.8	-1.9	2.1
Compulsive drug intake	2.4	2.8	2.9	1.7	1.7	-1.7
One hour access (shock baseline)	4.5	6.9	7.6	-2.5	-2.6	2.8
Social response proportion	0.0	0.0	0.1	-0.0	-0.1	0.4
Social responses	0.1	0.2	0.2	0.5	0.5	-0.3
Social time	0.0	0.1	0.1	0.0	-0.1	0.4
Soleus weight	3.3	9.8	10.8	-3.3	-3.2	2.9
Bone: stiffness	0.0	0.1	0.1	0.2	0.2	-0.3
Tibialis anterior weight	1.3	4.6	5.9	-2.4	-2.2	1.7
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.1	0.3	0.2	-0.3
Time to tail flick, vehicle, after self-admin	4.0	5.3	5.7	2.2	2.2	-2.4
Time to tail flick, test, before self-admin	0.1	0.1	0.1	-0.4	-0.4	0.3
Time to tail flick, test, after self-admin	0.9	1.0	1.0	-0.9	-1.0	1.0
Delta time to tail flick, vehicle, before/after SA	1.3	1.2	1.5	1.0	1.1	-1.2
Delta time to tail flick, test, before/after SA	2.5	2.5	2.8	-1.5	-1.6	1.7
Tibia length	1.1	2.9	3.9	2.0	1.8	-1.3
Ambulatory time before self-admin	0.1	0.1	0.2	-0.3	-0.4	0.4
Ambulatory time after self-admin	0.6	0.7	0.8	0.9	0.8	-0.7
Bone: tissue strength	0.7	0.7	0.8	0.9	0.8	-0.9
Total heroin consumption	2.1	2.5	2.8	-1.7	-1.6	1.4
Bone: trabecular number	2.3	3.8	4.2	-2.1	-2.0	1.9
Bone: trabecular spacing	0.9	1.2	1.6	1.3	1.1	-0.9
Bone: trabecular thickness	0.3	0.4	0.5	-0.7	-0.6	0.6
Bone: trabecular tissue density	0.3	0.5	0.5	-0.7	-0.7	0.6
Water consumed over 24 hours	0.2	0.2	0.4	0.3	0.4	-0.7
Number of responses in last shaping day	1.3	1.4	1.5	-1.2	-1.2	1.2