Hub : Genes

Cenpo

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Cenpo 0.02 0.02 7.9e-03 0 0 0 0 8.8e-02 2.7e-01 1.2e-01 3.5e-01
2 Adipose mRNA stability Cenpo 0.03 0.03 9.8e-04 0.02 0.01 0.01 0 6.6e-03 1.1e-02 2.9e-02 3.4e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density4.98.212.1-3.52.1
Area under the delay curve0.10.20.30.6-0.0
BMI with tail3.812.213.43.7-3.3
BMI without tail1.83.74.71.6-2.2
Body weight3.213.615.13.5-3.9
Weight adjusted by age2.02.32.51.6-1.4
Bone surface1.93.34.6-2.11.4
Bone volume3.25.57.6-2.81.8
Breakpoint value in progressive ratio session1.61.81.9-1.31.4
Number of licking bursts1.51.72.60.9-1.6
Context. condit. distance diff. score0.10.10.2-0.40.4
Locomotion velocity, session 10.40.40.90.1-0.9
Locomotion distance, session 10.60.81.5-1.20.3
Locomotion velocity, session 20.20.20.20.4-0.5
Locomotion distance, session 20.00.10.10.1-0.4
Locomotion velocity, session 30.20.20.2-0.5-0.4
Locomotion distance, session 30.00.00.0-0.2-0.2
Stereotopy head waving bouts, day 32.93.43.5-1.91.8
Stereotopy head waving duration, day 30.50.50.7-0.80.7
Locomotion velocity, session 70.00.00.10.20.3
Locomotion distance, session 71.01.32.11.4-0.7
Stereotopy head waving bouts, day 70.10.10.1-0.4-0.2
Stereotopy head waving duration, day 70.30.40.7-0.80.2
Locomotion velocity, session 80.91.11.9-1.40.5
Locomotion distance, session 80.60.91.0-0.81.0
Degree of sensitization distance1.81.83.01.7-0.8
Degree of sensitization stereotypy0.60.71.00.6-1.0
Conditioned locomotion1.51.81.9-1.41.3
Cocaine response after cond. corrected0.10.20.3-0.5-0.2
Cocaine response after cond. not corrected0.80.91.7-1.30.3
Cocaine response before conditioning2.02.52.5-1.61.6
Saline control response1.82.42.5-1.61.5
Bone: connectivity density3.25.08.0-2.81.4
Bone: cortical apparent density0.00.10.1-0.30.0
Bone: cortical area0.10.10.20.4-0.3
Bone: cortical porosity2.12.33.3-1.81.2
Bone: cortical porosity1.82.02.8-1.71.1
Bone: cortical thickness0.10.20.20.4-0.5
Bone: cortical thickness0.60.71.2-0.51.1
Bone: cortical tissue density0.00.10.1-0.3-0.1
Condit. Reinf. active minus inactive responses3.64.14.81.8-2.2
Condit. Reinf. active-inactive response ratio2.52.73.21.5-1.8
Condit. Reinf. active responses0.70.91.10.8-1.1
Condit. Reinf. inactive responses1.01.21.2-1.11.1
Incentive salience index mean1.21.52.30.8-1.5
Condit. Reinf. lever presses0.20.30.7-0.8-0.1
Condit. Reinf. active minus inactive responses0.40.50.7-0.80.6
Condit. Reinf. active-inactive response ratio0.30.30.7-0.80.1
Condit. Reinf. active responses0.10.10.1-0.30.2
Condit. Reinf. inactive responses0.00.00.10.2-0.1
Condit. Reinf. lever presses0.70.91.3-1.10.7
Condit. Reinf. lever reinforcers received0.10.10.1-0.30.3
Conditioned reinforcement - actives4.14.14.6-1.92.1
Conditioned reinforcement - inactives6.87.68.9-3.02.5
Conditioned locomotion6.07.27.6-2.62.8
Patch foraging indifference point 0 sec0.00.00.0-0.20.2
Patch foraging indifference point AUC0.10.10.20.2-0.5
Delay disc. indifference point, 0s delay0.40.40.80.9-0.2
Delay disc. indifference point, 16s delay0.10.10.20.50.0
Delay disc. indifference point, 2s delay0.00.10.10.20.2
Delay disc. indifference point, 24s delay2.82.73.5-1.91.4
Delay disc. indifference point, 4s delay0.40.50.91.00.1
Delay disc. indifference point, 8s delay0.00.00.10.30.1
Indifference point function ln k3.24.45.7-2.41.8
Indifference point function log k3.24.45.7-2.41.8
Patch foraging total patch changes 0 sec0.00.00.1-0.10.3
Patch foraging total patch changes 12 sec1.92.42.71.6-1.5
Patch foraging total patch changes 18 sec0.30.40.60.8-0.3
Patch foraging total patch changes 24 sec0.60.70.90.7-1.0
Patch foraging total patch changes 6 sec0.81.21.60.9-1.3
Patch foraging time to switch 0 sec0.91.52.61.6-0.6
Patch foraging water rate 0 sec3.15.06.5-2.51.9
Patch foraging water rate 12 sec0.10.10.1-0.3-0.3
Patch foraging water rate 18 sec2.63.64.1-2.01.7
Patch foraging water rate 24 sec0.00.00.0-0.1-0.1
Patch foraging water rate 6 sec0.60.81.3-1.10.7
Seeking ratio, delayed vs. immediate footshock0.30.30.40.6-0.5
Distance traveled before self-admin0.10.10.20.50.2
Distance traveled after self-admin0.00.00.10.3-0.1
Extensor digitorum longus weight2.18.412.7-3.62.0
Bone: elastic displacement2.02.33.4-1.81.1
Bone: elastic work1.62.12.3-1.41.5
Bone: endosteal estimation0.10.30.5-0.40.7
Bone: endosteal perimeter0.00.00.00.1-0.0
Epididymis fat weight19.545.446.76.8-6.6
Delta time in closed arm before/after self-admin0.30.30.50.7-0.4
Delta time in open arm before/after self-admin0.20.20.3-0.3-0.5
Diff in mean of infusions in LGA sessions0.30.30.70.1-0.8
Delay discount exponential model param0.10.10.1-0.3-0.2
Extinction: sum of active levers before priming0.00.00.1-0.2-0.0
Active lever presses in extinction session 61.51.52.7-1.6-0.6
Bone: final force0.00.00.0-0.2-0.1
Bone: final moment0.00.00.1-0.3-0.1
Food consumed during 24 hour testing period0.00.00.00.2-0.1
Glucose0.40.50.80.5-0.9
Heart weight4.46.38.62.9-2.0
Delay discount hyperbolic model param0.10.10.1-0.4-0.2
Intermittent access intake day 1-15 change4.24.26.0-1.52.4
Intermittent access intake escalation3.03.04.5-1.22.1
Intermittent access intake escalation 20.70.71.4-0.21.2
Intermitt. access day 1 inactive lever presses0.20.20.3-0.6-0.2
Intermitt. access day 15 inactive lever presses0.40.50.9-0.90.2
Intermitt. access escalation Index3.32.95.02.2-0.9
Intermittent access day 1 total infusions1.11.31.3-1.11.1
Intermittent access day 15 total infusions2.83.24.4-1.42.1
Intermittent access terminal intake (last 3 days)2.83.14.2-1.42.0
Intermittent access total infusions2.32.62.7-1.71.6
Intermittent access day 1 locomotion1.92.02.7-1.21.6
Intermittent access day 15 total locomotion0.50.50.9-0.50.9
Intermittent access total locomotion1.01.11.6-0.81.3
Intermittent access standard deviation0.30.40.6-0.40.7
Left kidney weight0.20.61.2-1.10.3
Right kidney weight0.30.91.50.5-1.2
Cocaine induced anxiety0.81.01.4-0.71.2
Post-drug Anxiety0.20.20.30.4-0.5
Baseline Anxiety1.81.91.91.4-1.4
Tail length0.20.51.0-1.00.2
Length with tail0.10.40.9-0.1-0.9
Length without tail0.00.10.1-0.3-0.2
Times rat made contact with spout1.51.72.1-1.41.1
Lifetime Intake2.73.13.4-1.91.6
Liver weight, left1.83.04.31.3-2.1
Liver weight, right4.77.88.12.8-2.7
Locomotor activity1.93.05.50.7-2.3
Locomotor testing distance1.93.25.60.9-2.4
Locomotor testing rearing0.30.50.8-0.4-0.9
Locomotion in novel chamber1.11.42.60.5-1.6
Locomotion in novel chamber post-restriction1.51.83.31.8-0.6
Fecal boli incidents, locomotor time 13.33.74.9-1.62.2
Change in fecal boli incidents, locomotor task3.23.04.62.2-1.2
Time >=10cm from walls, locomotor time 10.20.20.5-0.00.7
Bouts of movement, locomotor time 10.10.10.30.00.5
Total resting periods, locomotor time 10.20.20.5-0.00.7
Rest time, locomotor task time 10.20.20.4-0.10.6
Distance moved, locomotor task time 10.40.50.90.1-1.0
Vertical activity count, locomotor time 10.00.00.0-0.1-0.1
Time >=10cm from walls, locomotor time 21.81.92.7-1.11.6
Bouts of movement, locomotor time 20.80.91.71.30.2
Total resting periods, locomotor time 20.80.91.71.30.2
Rest time, locomotor task time 20.00.00.0-0.10.1
Distance moved, locomotor task time 20.30.30.6-0.80.2
Vertical activity count, locomotor time 20.70.71.1-1.10.6
Light reinforcement 10.10.10.2-0.4-0.0
Light reinforcement 21.62.13.6-0.81.9
Bone: marrow area0.20.30.5-0.40.7
Bone: maximum diameter0.00.10.1-0.10.3
Bone: maximum force0.00.00.00.10.0
Bone: maximum moment0.00.00.0-0.00.1
Mean time between licks in bursts1.62.22.71.6-1.3
Mean num. licks in bursts3.13.74.6-1.62.2
Cd content in liver0.10.10.20.5-0.3
Co content in liver2.02.42.8-1.41.7
Cu content in liver1.01.21.41.2-1.0
Fe content in liver0.10.20.3-0.20.5
K content in liver2.42.42.71.6-1.5
Mg content in liver1.31.31.81.3-1.0
Mn content in liver0.10.10.20.40.1
Na content in liver4.54.77.1-2.71.5
Rb content in liver0.70.91.01.0-0.9
Se content in liver0.81.01.31.1-0.8
Sr content in liver0.10.00.10.30.1
Zn content in liver5.25.76.12.3-2.5
Bone: minimum diameter1.12.12.71.6-1.2
Time in familiar zone, hab. session 11.41.31.61.3-1.0
Time in novel zone, hab. session 10.20.20.40.3-0.6
Total zone transitions, hab. session 10.30.40.7-0.90.4
Total locomotion distance, hab. session 11.01.52.5-1.60.7
Locomotion velocity, hab. session 11.92.73.8-1.91.2
Time in familiar zone, hab. session 20.00.00.00.2-0.1
Time in novel zone, hab. session 20.40.40.50.7-0.6
Total zone transitions, hab. session 20.30.40.7-0.80.1
Total locomotion distance, hab. session 20.20.20.4-0.6-0.1
Locomotion velocity, hab. session 20.20.30.6-0.8-0.0
Novel to familiar place preference ratio0.10.10.10.3-0.2
Novelty place preference0.30.30.40.5-0.6
Time in novel zone, NPP test0.40.40.40.6-0.6
Total zone transitions, NPP test0.50.71.3-1.10.2
Total locomotion distance, NPP test1.21.72.6-1.60.9
Locomotion velocity, NPP test1.82.54.1-2.01.0
Intraocular pressure2.63.74.32.1-1.8
Delta distance traveled before/after self-admin0.80.81.30.6-1.2
Delta ambulatory time before/after self-admin0.10.10.1-0.30.0
Parametrial fat weight14.027.332.44.7-5.7
Pavlov. Cond. lever latency0.20.20.50.7-0.1
Pavlov. Cond. magazine entry latency0.20.20.50.0-0.7
Pavlov. Cond. change in total contacts0.00.00.10.10.2
Pavlov. Cond. index score0.10.10.1-0.3-0.2
Pavlov. Cond. latency score0.10.10.1-0.4-0.1
Pavlov. Cond. lever contacts0.30.40.7-0.80.1
Pavlov. Cond. magazine entry number0.20.20.30.50.4
Pavlov. Cond. intertrial magazine entries1.01.21.8-0.71.3
Pavlov. Cond. lever-magazine prob. diff.0.20.30.5-0.70.2
Pavlov. Cond. response bias0.60.81.3-1.20.5
Pavlov. Cond. lever latency0.60.70.90.8-1.0
Pavlov. Cond. magazine entry latency0.00.00.0-0.0-0.0
Pavlov. Cond. change in total contacts0.00.00.0-0.10.1
Pavlov. Cond. index score0.40.60.6-0.80.7
Pavlov. Cond. latency score0.50.70.7-0.80.8
Pavlov. Cond. lever contacts0.00.00.1-0.10.2
Pavlov. Cond. magazine entry number0.10.20.2-0.50.3
Pavlov. Cond. intertrial magazine entries0.91.21.71.3-0.8
Pavlov. Cond. lever-magazine prob. diff.0.20.30.3-0.50.5
Pavlov. Cond. response bias0.10.20.2-0.30.5
Time in closed arm before self-admin0.00.00.1-0.2-0.1
Time in closed arm after self-admin0.80.91.60.3-1.3
Time in open arm before self-admin0.20.20.40.70.2
Time in open arm after self-admin0.20.20.40.00.6
Bone: periosteal estimation0.10.20.3-0.20.5
Bone: periosteal perimeter0.00.00.10.30.0
Bone: post-yield work1.21.61.8-1.31.2
Progressive ratio test 1 active lever presses0.80.91.6-1.30.3
Progressive ratio test 1 breakpoint0.70.71.3-1.20.4
Progressive ratio test 1 inactive lever presses1.82.02.6-1.61.2
Progressive ratio test 2 active lever presses2.22.42.9-1.41.7
Progressive ratio test 2 breakpoint2.32.63.2-1.41.8
Progressive ratio test 2 inactive lever presses3.64.14.4-2.02.1
Incentive Sensitization - Responses2.52.54.1-1.02.0
Incentive Sensitization - Breakpoint1.91.93.4-0.71.9
Sum of active levers in priming session hrs 5-60.00.00.0-0.10.0
Progressive ratio0.00.00.1-0.2-0.1
Food seeking constrained by brief footshock8.310.211.7-3.43.0
Seeking ratio, punishment vs. effort1.41.72.1-1.21.4
Retroperitoneal fat weight36.0118.3121.911.0-10.7
Reaction time number correct0.20.40.5-0.70.5
Reaction time mean minus median1.11.52.60.7-1.6
Reaction time mean minus median AUC1.62.03.40.8-1.9
Reaction time num false alarms3.64.85.52.3-2.0
Reaction time num false alarms AUC3.34.65.32.3-2.0
Reaction time trials correct on left0.20.40.5-0.70.5
Reaction time trials on left0.20.30.4-0.60.4
Reaction time mean0.20.30.50.7-0.5
Reaction time mean AUC0.20.20.30.6-0.4
Median of all reaction times0.10.10.10.30.3
Reaction time omissions1.41.93.20.7-1.8
Reaction time false alarm rate3.65.06.12.5-2.0
Reaction time premature initiation rate0.00.10.10.10.3
Reaction time premature initiations0.20.20.4-0.30.6
Std. dev. reaction times1.42.02.71.1-1.6
Reaction time trials completed0.20.30.4-0.60.4
Reaction time trials AUC0.20.20.4-0.60.3
Run reversals in cocaine runway, females0.70.71.2-0.51.1
Run reversals in cocaine runway, males1.11.11.6-1.30.7
Latency to leave start box in cocaine runway0.10.10.2-0.10.4
Latency to leave start box in cocaine runway, F0.10.10.10.3-0.3
Latency to leave start box in cocaine runway, M1.21.11.4-0.91.2
Std. dev. time between licks in bursts0.50.71.21.1-0.3
Total sessions with >9 infusions4.34.76.5-2.51.7
Short access day 1 total inactive lever presses1.71.92.5-1.61.2
Short access day 10 total inactive lever presses0.60.71.30.2-1.1
Short access day 1 total infusions2.22.32.7-1.71.4
Short access day 10 total infusions2.62.93.0-1.71.7
Short access total infusions2.12.43.1-1.81.3
Short access day 1 locomotion3.23.54.8-2.21.5
Short access day 10 total locomotion1.21.41.6-1.11.2
Short access total locomotion2.62.72.7-1.61.6
One hour access (0.3 mA shock)4.45.15.8-2.12.4
Compulsive drug intake1.41.42.51.6-0.6
One hour access (shock baseline)4.95.76.6-2.62.2
Social response proportion0.30.30.3-0.50.6
Social responses0.30.30.6-0.2-0.8
Social time0.00.00.0-0.20.2
Soleus weight3.410.113.2-3.62.6
Bone: stiffness0.20.30.50.7-0.1
Tibialis anterior weight1.23.96.2-2.51.3
Time to tail flick, vehicle, before self-admin1.41.42.70.3-1.6
Time to tail flick, vehicle, after self-admin7.88.410.32.5-3.2
Time to tail flick, test, before self-admin1.51.51.5-1.21.2
Time to tail flick, test, after self-admin1.11.21.6-1.30.9
Delta time to tail flick, vehicle, before/after SA2.22.12.91.7-1.2
Delta time to tail flick, test, before/after SA1.71.61.9-1.11.4
Tibia length0.92.43.61.1-1.9
Ambulatory time before self-admin0.20.20.30.6-0.2
Ambulatory time after self-admin0.00.00.00.1-0.1
Bone: tissue strength0.30.30.5-0.1-0.7
Total heroin consumption3.64.35.5-1.72.3
Bone: trabecular number4.67.211.0-3.31.8
Bone: trabecular spacing1.01.32.21.5-0.6
Bone: trabecular thickness0.10.10.2-0.5-0.2
Bone: trabecular tissue density0.20.30.60.80.3
Water consumed over 24 hours0.30.30.6-0.70.3
Number of responses in last shaping day1.51.51.7-1.31.1