Hub : Genes

Cenpo

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Cenpo 0.03 0.02 3.5e-03 0.01 0 0.01 0 5.2e-02 1.5e-01 5.7e-02 1.0e-01
2 Adipose mRNA stability Cenpo 0.03 0.03 2.5e-03 0.01 0.01 0.01 0 1.1e-02 4.3e-02 5.1e-02 1.1e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density2.75.05.3-2.32.1
Area under the delay curve0.00.00.0-0.1-0.2
BMI with tail3.712.813.13.6-3.5
BMI without tail1.910.210.63.3-3.1
Body weight3.414.815.03.8-3.9
Weight adjusted by age0.41.21.31.0-1.2
Bone surface0.40.80.9-1.00.8
Bone volume1.12.22.5-1.61.4
Breakpoint value in progressive ratio session0.50.91.0-1.00.9
Number of licking bursts0.82.42.61.5-1.6
Context. condit. distance diff. score0.20.30.3-0.60.5
Locomotion velocity, session 10.10.10.10.1-0.3
Locomotion distance, session 10.81.01.1-1.10.9
Locomotion velocity, session 20.70.91.00.9-1.0
Locomotion distance, session 20.00.00.0-0.0-0.2
Locomotion velocity, session 30.00.00.00.10.0
Locomotion distance, session 30.00.00.00.10.1
Stereotopy head waving bouts, day 32.73.23.4-1.91.7
Stereotopy head waving duration, day 30.40.50.6-0.80.7
Locomotion velocity, session 70.10.10.10.3-0.3
Locomotion distance, session 71.21.61.71.3-1.2
Stereotopy head waving bouts, day 70.10.10.2-0.40.3
Stereotopy head waving duration, day 70.50.60.7-0.80.7
Locomotion velocity, session 80.30.30.4-0.60.5
Locomotion distance, session 80.91.31.6-1.21.1
Degree of sensitization distance1.61.71.81.3-1.3
Degree of sensitization stereotypy0.10.10.20.3-0.4
Conditioned locomotion2.02.32.3-1.51.5
Cocaine response after cond. corrected0.10.10.1-0.30.3
Cocaine response after cond. not corrected0.50.70.8-0.80.9
Cocaine response before conditioning1.82.12.2-1.51.4
Saline control response1.31.82.0-1.41.3
Bone: connectivity density1.62.62.9-1.71.5
Bone: cortical apparent density0.10.20.3-0.40.5
Bone: cortical area0.00.00.00.1-0.1
Bone: cortical porosity1.71.91.9-1.41.4
Bone: cortical porosity1.41.51.6-1.31.2
Bone: cortical thickness0.10.10.10.3-0.3
Bone: cortical thickness0.30.30.4-0.50.6
Bone: cortical tissue density0.10.10.2-0.30.4
Condit. Reinf. active minus inactive responses2.93.33.51.9-1.8
Condit. Reinf. active-inactive response ratio2.52.63.11.7-1.5
Condit. Reinf. active responses0.40.50.50.6-0.7
Condit. Reinf. inactive responses1.11.41.8-1.31.1
Incentive salience index mean0.81.11.11.0-1.0
Condit. Reinf. lever presses0.40.60.7-0.80.6
Condit. Reinf. active minus inactive responses0.50.80.9-0.80.9
Condit. Reinf. active-inactive response ratio0.20.20.2-0.50.5
Condit. Reinf. active responses0.40.50.6-0.80.7
Condit. Reinf. inactive responses0.10.10.1-0.40.3
Condit. Reinf. lever presses0.91.31.4-1.01.2
Condit. Reinf. lever reinforcers received0.30.40.4-0.60.6
Conditioned reinforcement - actives1.76.77.2-2.52.7
Conditioned reinforcement - inactives3.910.611.0-3.23.3
Conditioned locomotion1.82.72.7-1.61.6
Patch foraging indifference point 0 sec0.00.00.00.2-0.1
Patch foraging indifference point AUC0.00.00.0-0.00.0
Delay disc. indifference point, 0s delay0.00.00.0-0.0-0.2
Delay disc. indifference point, 16s delay0.00.00.00.1-0.2
Delay disc. indifference point, 2s delay0.10.10.10.1-0.4
Delay disc. indifference point, 24s delay1.32.02.2-1.51.4
Delay disc. indifference point, 4s delay0.00.00.10.0-0.3
Delay disc. indifference point, 8s delay0.00.10.1-0.2-0.2
Indifference point function ln k1.02.93.0-1.71.7
Indifference point function log k1.02.93.0-1.71.7
Patch foraging total patch changes 0 sec0.00.00.10.3-0.2
Patch foraging total patch changes 12 sec1.62.12.21.5-1.5
Patch foraging total patch changes 18 sec0.20.60.60.8-0.7
Patch foraging total patch changes 24 sec0.31.01.01.0-1.0
Patch foraging total patch changes 6 sec1.11.81.91.4-1.3
Patch foraging time to switch 0 sec0.41.41.51.2-1.1
Patch foraging water rate 0 sec1.45.25.7-2.42.2
Patch foraging water rate 12 sec0.00.00.0-0.1-0.0
Patch foraging water rate 18 sec2.45.35.4-2.32.3
Patch foraging water rate 24 sec0.20.20.30.5-0.5
Patch foraging water rate 6 sec1.52.22.4-1.51.4
Seeking ratio, delayed vs. immediate footshock0.50.70.90.9-0.7
Distance traveled before self-admin0.00.00.00.10.0
Distance traveled after self-admin0.10.10.20.3-0.4
Extensor digitorum longus weight1.97.47.7-2.82.7
Bone: elastic displacement2.12.72.7-1.61.6
Bone: elastic work1.41.92.0-1.31.4
Bone: endosteal estimation0.10.30.3-0.50.6
Bone: endosteal perimeter0.00.00.00.1-0.1
Epididymis fat weight15.075.775.78.7-8.7
Delta time in closed arm before/after self-admin0.00.00.0-0.10.0
Delta time in open arm before/after self-admin0.50.60.60.8-0.8
Diff in mean of infusions in LGA sessions0.50.81.00.8-1.0
Delay discount exponential model param0.00.10.10.3-0.1
Extinction: sum of active levers before priming0.00.00.1-0.30.0
Active lever presses in extinction session 60.50.50.5-0.70.7
Bone: final force0.10.20.20.4-0.4
Bone: final moment0.00.00.10.2-0.2
Food consumed during 24 hour testing period0.00.00.1-0.20.2
Glucose0.91.51.71.3-1.1
Heart weight0.91.41.71.1-1.3
Delay discount hyperbolic model param0.00.00.00.10.2
Intermittent access intake day 1-15 change0.94.75.4-2.02.3
Intermittent access intake escalation0.73.94.4-1.82.1
Intermittent access intake escalation 21.42.42.9-1.41.7
Intermitt. access day 1 inactive lever presses0.10.70.8-0.90.8
Intermitt. access day 15 inactive lever presses0.21.11.1-1.01.1
Intermitt. access escalation Index1.23.83.92.0-1.9
Intermittent access day 1 total infusions0.51.51.9-1.41.1
Intermittent access day 15 total infusions2.04.94.9-2.22.2
Intermittent access terminal intake (last 3 days)3.76.56.7-2.62.5
Intermittent access total infusions3.23.84.0-2.01.9
Intermittent access day 1 locomotion1.42.73.1-1.81.5
Intermittent access day 15 total locomotion0.20.70.8-0.90.8
Intermittent access total locomotion1.92.22.4-1.51.5
Intermittent access standard deviation0.63.03.0-1.71.7
Left kidney weight0.00.10.20.2-0.4
Right kidney weight0.42.93.31.6-1.8
Cocaine induced anxiety0.30.80.8-0.80.9
Post-drug Anxiety0.70.80.90.9-1.0
Baseline Anxiety2.64.44.62.1-2.1
Tail length0.21.11.1-1.01.1
Length with tail0.10.30.30.5-0.6
Length without tail0.10.60.70.6-0.9
Times rat made contact with spout0.81.01.1-1.00.9
Lifetime Intake3.24.04.3-2.11.9
Liver weight, left1.01.81.81.3-1.3
Liver weight, right3.76.56.62.5-2.6
Locomotor activity2.03.13.31.8-1.7
Locomotor testing distance0.71.81.91.3-1.4
Locomotor testing rearing0.00.10.10.3-0.3
Locomotion in novel chamber1.41.81.81.4-1.3
Locomotion in novel chamber post-restriction0.41.21.21.1-1.1
Fecal boli incidents, locomotor time 11.23.33.4-1.81.8
Change in fecal boli incidents, locomotor task2.62.83.61.9-1.4
Time >=10cm from walls, locomotor time 10.10.10.1-0.40.4
Bouts of movement, locomotor time 10.40.60.9-0.90.5
Total resting periods, locomotor time 10.50.61.0-1.00.5
Rest time, locomotor task time 10.00.00.0-0.20.0
Distance moved, locomotor task time 10.20.70.80.9-0.7
Vertical activity count, locomotor time 10.00.00.10.3-0.0
Time >=10cm from walls, locomotor time 20.61.72.3-1.11.5
Bouts of movement, locomotor time 20.00.00.0-0.2-0.1
Total resting periods, locomotor time 20.00.00.0-0.2-0.1
Rest time, locomotor task time 20.00.00.0-0.20.0
Distance moved, locomotor task time 20.00.00.00.10.2
Vertical activity count, locomotor time 20.10.30.5-0.40.7
Light reinforcement 10.31.61.6-1.31.3
Light reinforcement 21.53.43.7-1.71.9
Bone: marrow area0.10.30.3-0.50.6
Bone: maximum diameter0.00.10.1-0.30.3
Bone: maximum force0.00.00.00.0-0.0
Bone: maximum moment0.00.00.0-0.20.2
Mean time between licks in bursts0.21.31.41.2-1.1
Mean num. licks in bursts1.54.04.0-2.02.0
Cd content in liver0.30.40.40.7-0.6
Co content in liver2.22.62.8-1.51.7
Cu content in liver0.20.30.30.5-0.6
Fe content in liver1.61.92.1-1.41.3
K content in liver1.01.01.01.0-1.0
Mg content in liver0.00.00.00.2-0.2
Mn content in liver0.70.80.91.0-0.8
Na content in liver3.74.14.2-2.02.0
Rb content in liver0.30.30.40.5-0.6
Se content in liver0.40.50.60.8-0.6
Sr content in liver0.30.20.3-0.40.6
Zn content in liver1.61.91.91.4-1.4
Bone: minimum diameter1.12.22.31.4-1.5
Time in familiar zone, hab. session 12.02.22.21.5-1.5
Time in novel zone, hab. session 10.20.30.30.6-0.5
Total zone transitions, hab. session 10.50.80.9-1.00.8
Total locomotion distance, hab. session 11.52.12.1-1.41.4
Locomotion velocity, hab. session 12.94.14.2-2.02.0
Time in familiar zone, hab. session 20.20.20.20.5-0.4
Time in novel zone, hab. session 20.40.50.50.7-0.7
Total zone transitions, hab. session 20.10.10.2-0.40.2
Total locomotion distance, hab. session 20.00.00.1-0.30.1
Locomotion velocity, hab. session 20.10.10.2-0.50.3
Novel to familiar place preference ratio0.00.00.0-0.10.2
Novelty place preference0.00.00.00.2-0.1
Time in novel zone, NPP test0.10.10.20.4-0.4
Total zone transitions, NPP test0.60.81.0-1.00.8
Total locomotion distance, NPP test1.31.82.1-1.41.2
Locomotion velocity, NPP test2.63.63.8-1.91.9
Intraocular pressure3.25.35.92.4-2.2
Delta distance traveled before/after self-admin0.50.60.60.7-0.8
Delta ambulatory time before/after self-admin0.00.00.0-0.20.0
Parametrial fat weight26.863.165.98.1-7.8
Pavlov. Cond. lever latency0.30.30.50.7-0.4
Pavlov. Cond. magazine entry latency0.00.00.0-0.1-0.2
Pavlov. Cond. change in total contacts0.00.00.1-0.3-0.0
Pavlov. Cond. index score0.00.00.1-0.3-0.0
Pavlov. Cond. latency score0.00.00.1-0.3-0.1
Pavlov. Cond. lever contacts0.20.30.4-0.70.3
Pavlov. Cond. magazine entry number0.10.20.30.5-0.3
Pavlov. Cond. intertrial magazine entries0.60.70.8-0.70.9
Pavlov. Cond. lever-magazine prob. diff.0.20.30.4-0.60.3
Pavlov. Cond. response bias0.60.70.9-1.00.7
Pavlov. Cond. lever latency0.50.60.60.8-0.8
Pavlov. Cond. magazine entry latency0.00.00.10.2-0.0
Pavlov. Cond. change in total contacts0.00.00.00.1-0.1
Pavlov. Cond. index score0.20.30.3-0.50.6
Pavlov. Cond. latency score0.20.40.5-0.50.7
Pavlov. Cond. lever contacts0.10.20.2-0.50.5
Pavlov. Cond. magazine entry number0.30.40.5-0.70.6
Pavlov. Cond. intertrial magazine entries0.61.21.31.1-1.1
Pavlov. Cond. lever-magazine prob. diff.0.10.10.1-0.20.3
Pavlov. Cond. response bias0.30.40.5-0.60.7
Time in closed arm before self-admin0.10.20.20.5-0.4
Time in closed arm after self-admin1.01.11.21.0-1.1
Time in open arm before self-admin0.00.00.00.1-0.1
Time in open arm after self-admin0.00.10.1-0.20.3
Bone: periosteal estimation0.10.20.2-0.40.5
Bone: periosteal perimeter0.00.00.0-0.10.1
Bone: post-yield work0.81.41.5-1.21.2
Progressive ratio test 1 active lever presses0.91.61.8-1.31.2
Progressive ratio test 1 breakpoint1.01.71.9-1.41.2
Progressive ratio test 1 inactive lever presses1.12.93.0-1.71.7
Progressive ratio test 2 active lever presses3.34.74.9-2.12.2
Progressive ratio test 2 breakpoint3.74.74.9-2.12.2
Progressive ratio test 2 inactive lever presses2.16.86.8-2.62.6
Incentive Sensitization - Responses1.54.24.9-1.92.2
Incentive Sensitization - Breakpoint1.73.84.4-1.82.1
Sum of active levers in priming session hrs 5-60.00.00.0-0.1-0.2
Progressive ratio0.10.30.30.6-0.6
Food seeking constrained by brief footshock7.49.29.2-3.03.0
Seeking ratio, punishment vs. effort1.33.03.0-1.71.7
Retroperitoneal fat weight42.7191.2194.714.0-13.7
Reaction time number correct0.20.80.9-0.90.8
Reaction time mean minus median0.32.02.21.5-1.3
Reaction time mean minus median AUC0.21.51.61.3-1.2
Reaction time num false alarms1.93.23.21.8-1.8
Reaction time num false alarms AUC1.32.92.91.7-1.7
Reaction time trials correct on left0.20.80.9-0.90.8
Reaction time trials on left0.20.60.7-0.80.7
Reaction time mean0.20.40.50.7-0.5
Reaction time mean AUC0.10.20.30.5-0.4
Median of all reaction times0.00.00.00.10.0
Reaction time omissions1.32.22.21.5-1.4
Reaction time false alarm rate2.94.04.22.0-1.9
Reaction time premature initiation rate0.00.00.00.1-0.0
Reaction time premature initiations0.10.30.3-0.50.6
Std. dev. reaction times0.61.92.11.5-1.3
Reaction time trials completed0.20.60.7-0.80.7
Reaction time trials AUC0.10.50.6-0.70.6
Run reversals in cocaine runway, females1.11.31.5-1.21.0
Run reversals in cocaine runway, males1.51.61.6-1.31.3
Latency to leave start box in cocaine runway0.10.10.1-0.10.3
Latency to leave start box in cocaine runway, F0.20.30.40.6-0.4
Latency to leave start box in cocaine runway, M0.90.90.9-0.91.0
Std. dev. time between licks in bursts0.30.50.50.7-0.7
Total sessions with >9 infusions2.02.52.7-1.71.5
Short access day 1 total inactive lever presses4.18.28.7-3.02.8
Short access day 10 total inactive lever presses0.10.70.8-0.70.9
Short access day 1 total infusions1.63.13.6-1.91.6
Short access day 10 total infusions2.23.63.8-1.91.8
Short access total infusions1.21.71.9-1.41.3
Short access day 1 locomotion0.81.31.5-1.21.1
Short access day 10 total locomotion0.52.02.2-1.51.4
Short access total locomotion1.11.72.0-1.41.2
One hour access (0.3 mA shock)5.86.87.3-2.72.5
Compulsive drug intake0.10.10.20.2-0.5
One hour access (shock baseline)2.66.76.9-2.62.6
Social response proportion0.10.10.10.4-0.2
Social responses0.50.60.70.8-0.7
Social time0.00.10.10.2-0.3
Soleus weight4.011.712.7-3.63.3
Bone: stiffness0.00.00.10.1-0.3
Tibialis anterior weight1.44.74.8-2.22.2
Time to tail flick, vehicle, before self-admin0.10.10.20.4-0.4
Time to tail flick, vehicle, after self-admin4.28.59.03.0-2.8
Time to tail flick, test, before self-admin0.00.00.0-0.10.2
Time to tail flick, test, after self-admin1.21.21.2-1.11.1
Delta time to tail flick, vehicle, before/after SA1.51.71.81.4-1.2
Delta time to tail flick, test, before/after SA2.43.03.2-1.81.7
Tibia length0.51.51.91.1-1.4
Ambulatory time before self-admin0.00.00.00.10.1
Ambulatory time after self-admin0.00.00.0-0.20.1
Bone: tissue strength0.20.20.30.3-0.5
Total heroin consumption4.75.55.7-2.42.3
Bone: trabecular number2.44.54.7-2.22.1
Bone: trabecular spacing0.30.50.50.7-0.7
Bone: trabecular thickness0.00.00.00.10.0
Bone: trabecular tissue density0.10.10.1-0.30.3
Water consumed over 24 hours0.10.10.20.3-0.4
Number of responses in last shaping day0.81.01.2-1.10.9