Hub : Genes

Cenpo

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Cenpo 0.03 0.02 3.5e-03 0.01 0 0.01 0 5.2e-02 1.5e-01 5.7e-02 1.1e-01
2 Adipose mRNA stability Cenpo 0.03 0.03 2.5e-03 0.01 0.01 0.01 0 1.1e-02 4.3e-02 5.1e-02 1.2e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density2.95.05.32.3-2.1
Area under the delay curve0.00.00.00.10.2
BMI with tail3.712.813.1-3.63.5
BMI without tail3.310.210.6-3.33.1
Body weight3.414.815.0-3.83.9
Weight adjusted by age0.81.21.3-1.01.2
Bone surface0.40.80.91.0-0.8
Bone volume1.22.22.51.6-1.4
Breakpoint value in progressive ratio session0.70.91.01.0-0.9
Number of licking bursts1.52.42.6-1.51.6
Context. condit. distance diff. score0.20.30.30.6-0.5
Locomotion velocity, session 10.10.10.1-0.10.3
Locomotion distance, session 10.81.01.11.1-0.9
Locomotion velocity, session 20.80.91.0-0.91.0
Locomotion distance, session 20.00.00.00.00.2
Locomotion velocity, session 30.00.00.0-0.1-0.0
Locomotion distance, session 30.00.00.0-0.1-0.1
Stereotopy head waving bouts, day 32.83.23.41.9-1.7
Stereotopy head waving duration, day 30.40.50.60.8-0.7
Locomotion velocity, session 70.10.10.1-0.30.3
Locomotion distance, session 71.21.61.7-1.31.2
Stereotopy head waving bouts, day 70.10.10.20.4-0.3
Stereotopy head waving duration, day 70.50.60.70.8-0.7
Locomotion velocity, session 80.30.30.40.6-0.5
Locomotion distance, session 80.91.31.61.2-1.1
Degree of sensitization distance1.71.71.8-1.31.3
Degree of sensitization stereotypy0.10.10.2-0.30.4
Conditioned locomotion2.02.32.31.5-1.5
Cocaine response after cond. corrected0.10.10.10.3-0.3
Cocaine response after cond. not corrected0.60.70.80.8-0.9
Cocaine response before conditioning1.82.12.21.5-1.4
Saline control response1.41.82.01.4-1.3
Bone: connectivity density1.72.62.91.7-1.5
Bone: cortical apparent density0.20.20.30.4-0.5
Bone: cortical area0.00.00.0-0.10.1
Bone: cortical porosity1.71.91.91.4-1.4
Bone: cortical porosity1.41.51.61.3-1.2
Bone: cortical thickness0.10.10.1-0.30.3
Bone: cortical thickness0.30.30.40.5-0.6
Bone: cortical tissue density0.10.10.20.3-0.4
Condit. Reinf. active minus inactive responses3.03.33.5-1.91.8
Condit. Reinf. active-inactive response ratio2.52.63.1-1.71.5
Condit. Reinf. active responses0.40.50.5-0.60.7
Condit. Reinf. inactive responses1.21.41.81.3-1.1
Incentive salience index mean0.91.11.1-1.01.0
Condit. Reinf. lever presses0.40.60.70.8-0.6
Condit. Reinf. active minus inactive responses0.60.80.90.8-0.9
Condit. Reinf. active-inactive response ratio0.20.20.20.5-0.5
Condit. Reinf. active responses0.40.50.60.8-0.7
Condit. Reinf. inactive responses0.10.10.10.4-0.3
Condit. Reinf. lever presses0.91.31.41.0-1.2
Condit. Reinf. lever reinforcers received0.30.40.40.6-0.6
Conditioned reinforcement - actives4.06.77.22.5-2.7
Conditioned reinforcement - inactives7.210.611.03.2-3.3
Conditioned locomotion2.12.72.71.6-1.6
Patch foraging indifference point 0 sec0.00.00.0-0.20.1
Patch foraging indifference point AUC0.00.00.00.0-0.0
Delay disc. indifference point, 0s delay0.00.00.00.00.2
Delay disc. indifference point, 16s delay0.00.00.0-0.10.2
Delay disc. indifference point, 2s delay0.10.10.1-0.10.4
Delay disc. indifference point, 24s delay1.82.02.21.5-1.4
Delay disc. indifference point, 4s delay0.00.00.1-0.00.3
Delay disc. indifference point, 8s delay0.00.10.10.20.2
Indifference point function ln k1.72.93.01.7-1.7
Indifference point function log k1.72.93.01.7-1.7
Patch foraging total patch changes 0 sec0.00.00.1-0.30.2
Patch foraging total patch changes 12 sec1.62.12.2-1.51.5
Patch foraging total patch changes 18 sec0.40.60.6-0.80.7
Patch foraging total patch changes 24 sec0.61.01.0-1.01.0
Patch foraging total patch changes 6 sec1.21.81.9-1.41.3
Patch foraging time to switch 0 sec0.71.41.5-1.21.1
Patch foraging water rate 0 sec2.55.25.72.4-2.2
Patch foraging water rate 12 sec0.00.00.00.10.0
Patch foraging water rate 18 sec3.45.35.42.3-2.3
Patch foraging water rate 24 sec0.20.20.3-0.50.5
Patch foraging water rate 6 sec1.52.22.41.5-1.4
Seeking ratio, delayed vs. immediate footshock0.60.70.9-0.90.7
Distance traveled before self-admin0.00.00.0-0.1-0.0
Distance traveled after self-admin0.10.10.2-0.30.4
Extensor digitorum longus weight1.97.47.72.8-2.7
Bone: elastic displacement2.32.72.71.6-1.6
Bone: elastic work1.41.92.01.3-1.4
Bone: endosteal estimation0.10.30.30.5-0.6
Bone: endosteal perimeter0.00.00.0-0.10.1
Epididymis fat weight22.175.775.7-8.78.7
Delta time in closed arm before/after self-admin0.00.00.00.1-0.0
Delta time in open arm before/after self-admin0.60.60.6-0.80.8
Diff in mean of infusions in LGA sessions0.70.81.0-0.81.0
Delay discount exponential model param0.10.10.1-0.30.1
Extinction: sum of active levers before priming0.00.00.10.3-0.0
Active lever presses in extinction session 60.50.50.50.7-0.7
Bone: final force0.10.20.2-0.40.4
Bone: final moment0.00.00.1-0.20.2
Food consumed during 24 hour testing period0.00.00.10.2-0.2
Glucose0.91.51.7-1.31.1
Heart weight0.91.41.7-1.11.3
Delay discount hyperbolic model param0.00.00.0-0.1-0.2
Intermittent access intake day 1-15 change2.34.75.42.0-2.3
Intermittent access intake escalation1.93.94.41.8-2.1
Intermittent access intake escalation 22.12.42.91.4-1.7
Intermitt. access day 1 inactive lever presses0.20.70.80.9-0.8
Intermitt. access day 15 inactive lever presses0.51.11.11.0-1.1
Intermitt. access escalation Index2.73.83.9-2.01.9
Intermittent access day 1 total infusions1.01.51.91.4-1.1
Intermittent access day 15 total infusions3.34.94.92.2-2.2
Intermittent access terminal intake (last 3 days)5.06.56.72.6-2.5
Intermittent access total infusions3.23.84.02.0-1.9
Intermittent access day 1 locomotion2.12.73.11.8-1.5
Intermittent access day 15 total locomotion0.40.70.80.9-0.8
Intermittent access total locomotion1.92.22.41.5-1.5
Intermittent access standard deviation1.43.03.01.7-1.7
Left kidney weight0.00.10.2-0.20.4
Right kidney weight0.62.93.3-1.61.8
Cocaine induced anxiety0.50.80.80.8-0.9
Post-drug Anxiety0.80.80.9-0.91.0
Baseline Anxiety3.84.44.6-2.12.1
Tail length0.31.11.11.0-1.1
Length with tail0.10.30.3-0.50.6
Length without tail0.20.60.7-0.60.9
Times rat made contact with spout0.81.01.11.0-0.9
Lifetime Intake3.34.04.32.1-1.9
Liver weight, left1.11.81.8-1.31.3
Liver weight, right3.76.56.6-2.52.6
Locomotor activity2.03.13.3-1.81.7
Locomotor testing distance1.01.81.9-1.31.4
Locomotor testing rearing0.00.10.1-0.30.3
Locomotion in novel chamber1.41.81.8-1.41.3
Locomotion in novel chamber post-restriction0.71.21.2-1.11.1
Fecal boli incidents, locomotor time 12.33.33.41.8-1.8
Change in fecal boli incidents, locomotor task2.82.83.6-1.91.4
Time >=10cm from walls, locomotor time 10.10.10.10.4-0.4
Bouts of movement, locomotor time 10.50.60.90.9-0.5
Total resting periods, locomotor time 10.60.61.01.0-0.5
Rest time, locomotor task time 10.00.00.00.2-0.0
Distance moved, locomotor task time 10.40.70.8-0.90.7
Vertical activity count, locomotor time 10.00.00.1-0.30.0
Time >=10cm from walls, locomotor time 21.21.72.31.1-1.5
Bouts of movement, locomotor time 20.00.00.00.20.1
Total resting periods, locomotor time 20.00.00.00.20.1
Rest time, locomotor task time 20.00.00.00.2-0.0
Distance moved, locomotor task time 20.00.00.0-0.1-0.2
Vertical activity count, locomotor time 20.20.30.50.4-0.7
Light reinforcement 10.61.61.61.3-1.3
Light reinforcement 22.23.43.71.7-1.9
Bone: marrow area0.10.30.30.5-0.6
Bone: maximum diameter0.00.10.10.3-0.3
Bone: maximum force0.00.00.0-0.00.0
Bone: maximum moment0.00.00.00.2-0.2
Mean time between licks in bursts0.51.31.4-1.21.1
Mean num. licks in bursts2.54.04.02.0-2.0
Cd content in liver0.30.40.4-0.70.6
Co content in liver2.22.62.81.5-1.7
Cu content in liver0.20.30.3-0.50.6
Fe content in liver1.61.92.11.4-1.3
K content in liver1.01.01.0-1.01.0
Mg content in liver0.00.00.0-0.20.2
Mn content in liver0.70.80.9-1.00.8
Na content in liver3.84.14.22.0-2.0
Rb content in liver0.30.30.4-0.50.6
Se content in liver0.40.50.6-0.80.6
Sr content in liver0.30.20.30.4-0.6
Zn content in liver1.71.91.9-1.41.4
Bone: minimum diameter1.22.22.3-1.41.5
Time in familiar zone, hab. session 12.32.22.2-1.51.5
Time in novel zone, hab. session 10.30.30.3-0.60.5
Total zone transitions, hab. session 10.50.80.91.0-0.8
Total locomotion distance, hab. session 11.52.12.11.4-1.4
Locomotion velocity, hab. session 12.94.14.22.0-2.0
Time in familiar zone, hab. session 20.20.20.2-0.50.4
Time in novel zone, hab. session 20.50.50.5-0.70.7
Total zone transitions, hab. session 20.10.10.20.4-0.2
Total locomotion distance, hab. session 20.00.00.10.3-0.1
Locomotion velocity, hab. session 20.10.10.20.5-0.3
Novel to familiar place preference ratio0.00.00.00.1-0.2
Novelty place preference0.00.00.0-0.20.1
Time in novel zone, NPP test0.10.10.2-0.40.4
Total zone transitions, NPP test0.60.81.01.0-0.8
Total locomotion distance, NPP test1.31.82.11.4-1.2
Locomotion velocity, NPP test2.63.63.81.9-1.9
Intraocular pressure3.75.35.9-2.42.2
Delta distance traveled before/after self-admin0.50.60.6-0.70.8
Delta ambulatory time before/after self-admin0.00.00.00.2-0.0
Parametrial fat weight26.863.165.9-8.17.8
Pavlov. Cond. lever latency0.30.30.5-0.70.4
Pavlov. Cond. magazine entry latency0.00.00.00.10.2
Pavlov. Cond. change in total contacts0.00.00.10.30.0
Pavlov. Cond. index score0.00.00.10.30.0
Pavlov. Cond. latency score0.00.00.10.30.1
Pavlov. Cond. lever contacts0.20.30.40.7-0.3
Pavlov. Cond. magazine entry number0.10.20.3-0.50.3
Pavlov. Cond. intertrial magazine entries0.60.70.80.7-0.9
Pavlov. Cond. lever-magazine prob. diff.0.20.30.40.6-0.3
Pavlov. Cond. response bias0.60.70.91.0-0.7
Pavlov. Cond. lever latency0.50.60.6-0.80.8
Pavlov. Cond. magazine entry latency0.00.00.1-0.20.0
Pavlov. Cond. change in total contacts0.00.00.0-0.10.1
Pavlov. Cond. index score0.20.30.30.5-0.6
Pavlov. Cond. latency score0.30.40.50.5-0.7
Pavlov. Cond. lever contacts0.20.20.20.5-0.5
Pavlov. Cond. magazine entry number0.30.40.50.7-0.6
Pavlov. Cond. intertrial magazine entries0.81.21.3-1.11.1
Pavlov. Cond. lever-magazine prob. diff.0.10.10.10.2-0.3
Pavlov. Cond. response bias0.30.40.50.6-0.7
Time in closed arm before self-admin0.10.20.2-0.50.4
Time in closed arm after self-admin1.11.11.2-1.01.1
Time in open arm before self-admin0.00.00.0-0.10.1
Time in open arm after self-admin0.00.10.10.2-0.3
Bone: periosteal estimation0.10.20.20.4-0.5
Bone: periosteal perimeter0.00.00.00.1-0.1
Bone: post-yield work1.01.41.51.2-1.2
Progressive ratio test 1 active lever presses1.31.61.81.3-1.2
Progressive ratio test 1 breakpoint1.41.71.91.4-1.2
Progressive ratio test 1 inactive lever presses2.02.93.01.7-1.7
Progressive ratio test 2 active lever presses4.04.74.92.1-2.2
Progressive ratio test 2 breakpoint4.14.74.92.1-2.2
Progressive ratio test 2 inactive lever presses4.26.86.82.6-2.6
Incentive Sensitization - Responses3.04.24.91.9-2.2
Incentive Sensitization - Breakpoint2.93.84.41.8-2.1
Sum of active levers in priming session hrs 5-60.00.00.00.10.2
Progressive ratio0.20.30.3-0.60.6
Food seeking constrained by brief footshock7.59.29.23.0-3.0
Seeking ratio, punishment vs. effort2.13.03.01.7-1.7
Retroperitoneal fat weight44.8191.2194.7-14.013.7
Reaction time number correct0.40.80.90.9-0.8
Reaction time mean minus median0.82.02.2-1.51.3
Reaction time mean minus median AUC0.61.51.6-1.31.2
Reaction time num false alarms2.33.23.2-1.81.8
Reaction time num false alarms AUC1.92.92.9-1.71.7
Reaction time trials correct on left0.40.80.90.9-0.8
Reaction time trials on left0.30.60.70.8-0.7
Reaction time mean0.20.40.5-0.70.5
Reaction time mean AUC0.10.20.3-0.50.4
Median of all reaction times0.00.00.0-0.1-0.0
Reaction time omissions1.52.22.2-1.51.4
Reaction time false alarm rate2.94.04.2-2.01.9
Reaction time premature initiation rate0.00.00.0-0.10.0
Reaction time premature initiations0.20.30.30.5-0.6
Std. dev. reaction times1.01.92.1-1.51.3
Reaction time trials completed0.30.60.70.8-0.7
Reaction time trials AUC0.30.50.60.7-0.6
Run reversals in cocaine runway, females1.31.31.51.2-1.0
Run reversals in cocaine runway, males1.61.61.61.3-1.3
Latency to leave start box in cocaine runway0.10.10.10.1-0.3
Latency to leave start box in cocaine runway, F0.20.30.4-0.60.4
Latency to leave start box in cocaine runway, M0.90.90.90.9-1.0
Std. dev. time between licks in bursts0.40.50.5-0.70.7
Total sessions with >9 infusions2.12.52.71.7-1.5
Short access day 1 total inactive lever presses6.28.28.73.0-2.8
Short access day 10 total inactive lever presses0.30.70.80.7-0.9
Short access day 1 total infusions2.43.13.61.9-1.6
Short access day 10 total infusions2.83.63.81.9-1.8
Short access total infusions1.41.71.91.4-1.3
Short access day 1 locomotion1.11.31.51.2-1.1
Short access day 10 total locomotion1.12.02.21.5-1.4
Short access total locomotion1.41.72.01.4-1.2
One hour access (0.3 mA shock)5.96.87.32.7-2.5
Compulsive drug intake0.10.10.2-0.20.5
One hour access (shock baseline)4.46.76.92.6-2.6
Social response proportion0.10.10.1-0.40.2
Social responses0.50.60.7-0.80.7
Social time0.10.10.1-0.20.3
Soleus weight4.011.712.73.6-3.3
Bone: stiffness0.00.00.1-0.10.3
Tibialis anterior weight1.44.74.82.2-2.2
Time to tail flick, vehicle, before self-admin0.10.10.2-0.40.4
Time to tail flick, vehicle, after self-admin6.48.59.0-3.02.8
Time to tail flick, test, before self-admin0.00.00.00.1-0.2
Time to tail flick, test, after self-admin1.21.21.21.1-1.1
Delta time to tail flick, vehicle, before/after SA1.71.71.8-1.41.2
Delta time to tail flick, test, before/after SA2.93.03.21.8-1.7
Tibia length0.61.51.9-1.11.4
Ambulatory time before self-admin0.00.00.0-0.1-0.1
Ambulatory time after self-admin0.00.00.00.2-0.1
Bone: tissue strength0.20.20.3-0.30.5
Total heroin consumption4.75.55.72.4-2.3
Bone: trabecular number2.74.54.72.2-2.1
Bone: trabecular spacing0.40.50.5-0.70.7
Bone: trabecular thickness0.00.00.0-0.1-0.0
Bone: trabecular tissue density0.10.10.10.3-0.3
Water consumed over 24 hours0.10.10.2-0.30.4
Number of responses in last shaping day1.01.01.21.1-0.9