Hub : Genes

Plekhs1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Plekhs1	0.03	0.02	1.4e-03	0.04	0.02	0.01	0.03	5.9e-05	2.7e-03	1.4e-02	4.6e-04
2	Liver	mRNA stability	Plekhs1	0.07	0.06	1.5e-04	0.03	0.04	0.04	0.03	1.9e-04	8.6e-05	7.0e-05	1.9e-04
3	Eye	intron excision ratio	chr1_255507441_255507550	0.57	0.17	8.4e-04	0.17	0.12	0.22	0.15	1.5e-03	6.5e-03	2.6e-04	2.6e-03
4	Liver	gene expression	Plekhs1	0.12	0.06	5.3e-12	0.12	0.09	0.1	0.11	2.4e-13	2.2e-10	3.3e-11	1.6e-12

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	1.2	2.0	4.1	-2.0	0.5	-1.8	-0.7
Area under the delay curve	0.5	0.5	0.8	-0.9	0.6	-0.8	0.4
BMI with tail	6.3	20.4	44.3	-6.7	4.3	-2.7	3.3
BMI without tail	2.8	5.7	14.6	-3.8	2.1	-1.3	1.4
Body weight	6.9	28.9	63.7	-8.0	5.0	-3.2	4.1
Weight adjusted by age	5.7	6.5	9.0	-2.7	3.0	-2.0	2.3
Bone surface	0.5	0.9	2.3	-1.5	0.3	-1.0	-0.3
Bone volume	1.7	2.8	7.4	-2.7	1.1	-1.6	0.0
Breakpoint value in progressive ratio session	0.3	0.4	0.5	-0.7	-0.7	-0.1	-0.7
Number of licking bursts	0.4	0.4	1.2	-1.1	0.1	-0.6	-0.3
Context. condit. distance diff. score	1.4	1.7	3.9	0.7	-1.4	2.0	-0.6
Locomotion velocity, session 1	0.4	0.5	1.4	1.2	0.0	-0.7	-0.2
Locomotion distance, session 1	0.7	0.8	1.6	0.5	1.2	0.3	1.3
Locomotion velocity, session 2	0.7	0.8	1.5	0.6	0.7	1.0	1.2
Locomotion distance, session 2	1.9	2.6	4.1	-1.6	2.0	0.1	2.0
Locomotion velocity, session 3	0.7	0.8	1.7	0.0	1.1	0.7	1.3
Locomotion distance, session 3	1.2	1.3	2.4	-0.1	1.0	1.5	1.4
Stereotopy head waving bouts, day 3	0.2	0.2	0.3	-0.0	0.6	-0.5	0.5
Stereotopy head waving duration, day 3	0.4	0.5	1.1	0.9	-0.2	-1.0	-0.4
Locomotion velocity, session 7	0.1	0.1	0.3	-0.5	0.0	-0.5	-0.1
Locomotion distance, session 7	0.2	0.2	0.4	0.0	-0.6	0.7	-0.1
Stereotopy head waving bouts, day 7	0.1	0.1	0.4	-0.3	0.0	-0.6	0.0
Stereotopy head waving duration, day 7	0.8	1.0	2.4	-0.9	0.7	-1.6	0.4
Locomotion velocity, session 8	2.1	2.5	3.3	1.3	-1.8	1.8	-1.3
Locomotion distance, session 8	1.0	1.4	5.1	0.3	-0.6	2.3	0.2
Degree of sensitization distance	1.8	1.8	3.6	0.4	-1.9	-0.3	-1.8
Degree of sensitization stereotypy	0.2	0.2	0.5	-0.5	-0.2	-0.7	-0.4
Conditioned locomotion	0.1	0.1	0.3	0.5	-0.1	0.3	0.1
Cocaine response after cond. corrected	1.2	1.3	2.8	1.5	-0.3	1.7	0.4
Cocaine response after cond. not corrected	1.5	1.6	3.8	1.9	-0.8	1.5	-0.2
Cocaine response before conditioning	0.8	1.0	1.6	0.6	-1.2	-0.6	-1.3
Saline control response	0.3	0.4	0.6	0.8	0.6	-0.2	0.7
Bone: connectivity density	0.4	0.6	1.3	-0.1	-0.8	-0.6	-1.2
Bone: cortical apparent density	1.5	2.0	3.0	1.2	0.9	1.7	1.7
Bone: cortical area	7.8	11.7	21.5	-4.6	3.5	-2.8	2.3
Bone: cortical porosity	0.2	0.2	0.3	-0.5	-0.2	-0.4	-0.6
Bone: cortical porosity	0.4	0.4	0.8	-0.9	-0.4	-0.3	-0.8
Bone: cortical thickness	4.2	6.8	10.7	-3.3	2.9	-1.7	2.3
Bone: cortical thickness	1.9	2.3	3.9	-2.0	1.6	0.0	1.6
Bone: cortical tissue density	1.6	2.1	3.5	1.3	0.7	1.9	1.5
Condit. Reinf. active minus inactive responses	0.1	0.2	0.4	0.1	0.6	0.3	0.4
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	0.4	0.2	0.2	-0.3
Condit. Reinf. active responses	0.9	1.1	2.1	-0.6	1.5	-1.1	0.9
Condit. Reinf. inactive responses	1.8	2.2	4.5	-0.8	1.5	-2.1	1.0
Incentive salience index mean	0.2	0.2	0.4	0.6	0.6	0.2	0.4
Condit. Reinf. lever presses	0.2	0.3	0.5	0.7	0.6	-0.4	0.2
Condit. Reinf. active minus inactive responses	2.6	3.2	10.6	-0.7	1.3	-3.2	-0.2
Condit. Reinf. active-inactive response ratio	1.2	1.2	4.3	-0.1	0.3	-2.1	-0.8
Condit. Reinf. active responses	3.6	5.0	14.2	-1.4	1.9	-3.8	0.4
Condit. Reinf. inactive responses	1.5	1.8	3.8	-1.0	1.3	-2.0	0.8
Condit. Reinf. lever presses	0.6	0.8	1.8	-1.0	0.6	-1.4	-0.1
Condit. Reinf. lever reinforcers received	2.8	3.9	11.2	-1.2	1.7	-3.4	0.3
Conditioned reinforcement - actives	0.7	0.7	1.6	0.4	1.0	0.4	1.3
Conditioned reinforcement - inactives	0.8	0.9	1.2	-0.8	1.1	-0.6	1.1
Conditioned locomotion	0.4	0.5	0.8	0.7	0.7	0.6	0.9
Patch foraging indifference point 0 sec	2.9	4.7	7.1	-2.7	1.8	-2.6	1.5
Patch foraging indifference point AUC	1.0	1.2	4.2	-0.4	0.5	-2.1	-0.2
Delay disc. indifference point, 0s delay	0.7	0.8	1.3	-1.2	0.8	-0.0	1.2
Delay disc. indifference point, 16s delay	0.1	0.1	0.2	-0.0	-0.2	-0.4	-0.3
Delay disc. indifference point, 2s delay	0.2	0.3	0.8	-0.2	-0.4	0.9	-0.0
Delay disc. indifference point, 24s delay	0.8	0.8	2.1	-0.7	-0.2	-1.4	-0.7
Delay disc. indifference point, 4s delay	0.2	0.2	0.3	-0.0	-0.5	0.6	-0.3
Delay disc. indifference point, 8s delay	4.2	4.3	6.9	-1.9	2.2	-2.6	1.4
Indifference point function ln k	0.1	0.1	0.5	0.2	-0.1	0.7	0.0
Indifference point function log k	0.1	0.1	0.5	0.2	-0.1	0.7	0.0
Patch foraging total patch changes 0 sec	2.9	4.6	7.0	-2.6	1.7	-2.6	1.3
Patch foraging total patch changes 12 sec	1.1	1.5	3.8	-1.4	0.4	-1.9	-0.1
Patch foraging total patch changes 18 sec	3.5	4.5	10.6	-2.1	1.5	-3.3	0.8
Patch foraging total patch changes 24 sec	2.5	3.1	8.6	-1.6	0.9	-2.9	0.3
Patch foraging total patch changes 6 sec	4.5	6.7	9.7	-3.0	2.3	-3.1	1.8
Patch foraging time to switch 0 sec	0.5	0.7	1.5	0.9	-0.7	1.2	-0.2
Patch foraging water rate 0 sec	0.4	0.7	1.1	-1.0	0.8	-1.0	0.4
Patch foraging water rate 12 sec	1.0	1.6	5.0	-1.1	0.3	-2.2	-0.3
Patch foraging water rate 18 sec	0.6	0.8	1.1	-1.0	1.1	-0.2	1.0
Patch foraging water rate 24 sec	1.3	1.9	4.3	-2.1	1.3	-0.0	1.2
Patch foraging water rate 6 sec	0.5	0.7	1.2	-1.0	0.8	0.2	1.1
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.5	0.2	-0.4	0.7	-0.3
Distance traveled before self-admin	0.9	1.0	3.5	0.5	-0.3	1.9	0.3
Distance traveled after self-admin	1.4	1.5	3.9	-0.8	0.7	2.0	1.1
Extensor digitorum longus weight	0.2	0.8	1.8	-1.3	0.2	-1.2	-0.4
Bone: elastic displacement	0.1	0.1	0.2	0.1	-0.4	0.2	-0.4
Bone: elastic work	1.1	1.4	2.0	-1.4	1.3	0.3	1.4
Bone: endosteal estimation	1.2	2.7	7.0	-2.7	1.3	-1.2	0.8
Bone: endosteal perimeter	4.0	8.3	14.2	-3.8	3.1	-2.0	2.3
Epididymis fat weight	10.6	24.7	50.9	-7.1	4.6	-3.5	3.7
Delta time in closed arm before/after self-admin	0.5	0.5	1.2	0.1	0.2	1.1	0.7
Delta time in open arm before/after self-admin	0.4	0.4	1.2	-0.6	0.1	-1.1	-0.3
Diff in mean of infusions in LGA sessions	3.8	4.2	7.6	1.6	-2.8	0.8	-2.4
Delay discount exponential model param	0.5	0.6	0.9	1.0	-0.6	0.9	-0.4
Extinction: sum of active levers before priming	0.6	0.6	0.9	0.4	-0.9	0.6	-0.9
Active lever presses in extinction session 6	0.4	0.4	0.6	-0.7	0.6	0.8	0.2
Bone: final force	2.6	4.2	7.1	-2.7	2.3	-1.3	1.5
Bone: final moment	2.7	4.4	8.7	-3.0	2.3	-1.3	1.5
Food consumed during 24 hour testing period	0.4	0.5	1.9	-0.1	-0.3	1.4	-0.3
Glucose	3.7	5.6	7.4	-2.7	2.5	-1.5	2.6
Heart weight	2.7	3.8	5.8	-2.4	2.1	-1.3	1.7
Delay discount hyperbolic model param	0.3	0.3	0.7	0.8	-0.4	0.5	-0.3
Intermittent access intake day 1-15 change	2.3	2.3	3.0	-1.7	1.6	-1.2	1.5
Intermittent access intake escalation	4.0	4.0	5.7	-2.1	2.3	-0.4	2.4
Intermittent access intake escalation 2	2.4	2.4	4.3	-1.6	1.7	0.3	2.1
Intermitt. access day 1 inactive lever presses	1.3	1.4	3.0	-1.7	0.4	-1.5	0.0
Intermitt. access day 15 inactive lever presses	0.1	0.2	0.3	-0.4	0.5	-0.3	0.4
Intermitt. access escalation Index	0.4	0.4	1.2	-0.4	-0.1	1.1	0.2
Intermittent access day 1 total infusions	0.2	0.2	0.4	-0.3	0.7	-0.3	0.4
Intermittent access day 15 total infusions	1.7	1.9	2.8	-1.4	1.7	-0.2	1.6
Intermittent access terminal intake (last 3 days)	0.8	0.9	1.4	-0.9	1.2	-0.3	1.2
Intermittent access total infusions	1.5	1.6	2.9	-0.9	1.7	-0.9	1.4
Intermittent access day 1 locomotion	0.2	0.2	0.4	0.1	0.5	0.6	0.6
Intermittent access day 15 total locomotion	2.3	2.5	3.2	-1.6	1.8	-1.6	1.3
Intermittent access total locomotion	0.9	1.0	2.1	-0.4	1.4	-0.1	1.4
Intermittent access standard deviation	0.9	0.9	1.7	-1.3	0.6	-1.3	0.4
Left kidney weight	4.0	11.4	15.7	-4.0	3.4	1.6	3.9
Right kidney weight	5.2	14.6	20.8	-4.6	4.3	-0.3	4.3
Cocaine induced anxiety	4.8	5.6	9.5	2.4	-2.3	3.1	-1.3
Post-drug Anxiety	1.3	1.4	4.1	0.7	-0.9	2.0	-0.3
Baseline Anxiety	5.3	5.7	8.9	-3.0	2.4	-2.5	1.5
Tail length	0.2	0.5	1.4	-1.2	0.4	-0.5	0.5
Length with tail	1.8	6.7	13.4	-3.7	2.5	-1.4	2.3
Length without tail	4.3	9.3	15.4	-3.9	3.1	-1.9	2.9
Times rat made contact with spout	0.8	0.9	1.7	-1.3	1.0	0.5	0.9
Lifetime Intake	1.7	1.9	3.4	-1.0	1.9	-1.0	1.5
Liver weight, left	3.1	4.9	9.9	-3.1	2.1	-1.8	1.4
Liver weight, right	6.0	9.9	20.3	-4.5	3.0	-1.6	2.8
Locomotor activity	0.9	1.5	2.2	-1.3	1.5	-0.3	1.4
Locomotor testing distance	2.0	3.3	6.4	-1.4	2.2	0.0	2.5
Locomotor testing rearing	1.0	1.5	2.7	-1.2	1.3	0.2	1.6
Locomotion in novel chamber	0.8	1.0	3.1	-0.3	0.4	1.8	0.9
Locomotion in novel chamber post-restriction	0.6	0.8	1.9	1.4	0.1	1.0	0.1
Fecal boli incidents, locomotor time 1	1.7	1.9	6.3	0.1	1.0	-2.5	0.4
Change in fecal boli incidents, locomotor task	2.6	2.5	4.4	0.4	-1.7	2.1	-1.5
Time >=10cm from walls, locomotor time 1	1.9	1.9	2.3	1.3	-1.5	1.2	-1.4
Bouts of movement, locomotor time 1	1.1	1.2	2.7	-1.4	0.4	-1.6	-0.2
Total resting periods, locomotor time 1	0.9	1.0	2.0	-1.4	0.5	-1.3	-0.1
Rest time, locomotor task time 1	0.5	0.6	1.0	-0.7	1.0	-0.2	1.0
Distance moved, locomotor task time 1	0.3	0.3	0.5	0.1	-0.6	0.7	-0.7
Vertical activity count, locomotor time 1	1.3	1.4	3.5	0.8	-1.0	1.9	-0.5
Time >=10cm from walls, locomotor time 2	0.4	0.4	0.7	-0.7	-0.7	-0.1	-0.8
Bouts of movement, locomotor time 2	2.0	2.2	3.5	1.1	-1.9	1.5	-1.2
Total resting periods, locomotor time 2	1.2	1.3	2.0	0.7	-1.4	1.4	-0.9
Rest time, locomotor task time 2	0.2	0.2	0.4	0.1	0.5	0.3	0.7
Distance moved, locomotor task time 2	0.3	0.3	0.9	-0.3	0.2	-0.9	-0.5
Vertical activity count, locomotor time 2	0.2	0.2	0.6	-0.5	0.2	-0.8	0.1
Light reinforcement 1	1.2	2.1	2.8	1.3	-1.7	1.6	-1.3
Light reinforcement 2	1.8	2.4	3.4	1.5	-1.6	1.8	-1.1
Bone: marrow area	1.3	2.8	7.4	-2.7	1.3	-1.2	0.8
Bone: maximum diameter	6.3	11.5	22.2	-4.7	3.2	-3.1	2.0
Bone: maximum force	2.4	4.1	7.0	-2.6	2.3	-1.2	1.6
Bone: maximum moment	2.5	4.3	8.4	-2.9	2.3	-1.1	1.5
Mean time between licks in bursts	0.1	0.1	0.4	-0.2	-0.3	-0.3	-0.6
Mean num. licks in bursts	0.7	0.9	1.8	-0.1	1.0	0.9	1.3
Cd content in liver	2.4	2.6	3.7	1.9	-1.8	0.5	-1.8
Co content in liver	0.1	0.1	0.2	0.5	-0.3	0.0	-0.1
Cu content in liver	0.1	0.1	0.2	-0.3	0.4	0.0	0.1
Fe content in liver	0.1	0.1	0.4	0.2	0.0	-0.6	-0.1
K content in liver	0.7	0.7	1.4	0.6	-1.1	-0.0	-1.2
Mg content in liver	0.6	0.6	1.9	0.0	-0.8	-0.4	-1.4
Mn content in liver	1.3	1.5	2.1	1.0	-1.4	1.4	-1.0
Na content in liver	1.0	1.0	1.5	0.9	-1.2	-0.6	-1.2
Rb content in liver	1.4	1.8	2.8	1.3	-1.7	0.1	-1.6
Se content in liver	0.5	0.6	0.8	0.9	-0.6	-0.7	-0.8
Sr content in liver	2.0	1.8	2.4	1.5	-1.4	1.6	-0.8
Zn content in liver	2.4	2.7	3.3	1.8	-1.6	1.7	-1.5
Bone: minimum diameter	2.7	5.1	12.2	-3.5	1.9	-1.8	1.1
Time in familiar zone, hab. session 1	0.2	0.1	0.6	0.8	-0.0	0.0	0.1
Time in novel zone, hab. session 1	0.5	0.5	1.5	-1.2	0.2	-0.7	0.0
Total zone transitions, hab. session 1	1.7	2.4	3.5	-1.7	1.8	-0.0	1.9
Total locomotion distance, hab. session 1	0.2	0.3	0.8	-0.6	0.1	0.9	0.5
Locomotion velocity, hab. session 1	0.3	0.4	1.2	-0.3	0.1	1.1	0.4
Time in familiar zone, hab. session 2	1.2	1.3	2.9	-1.7	0.5	-1.3	-0.4
Time in novel zone, hab. session 2	0.5	0.5	0.9	0.9	0.3	0.7	0.9
Total zone transitions, hab. session 2	1.9	2.5	3.5	-1.8	1.9	-0.3	1.9
Total locomotion distance, hab. session 2	1.1	1.4	2.1	-1.5	1.1	0.8	1.3
Locomotion velocity, hab. session 2	0.8	1.1	1.4	-1.1	0.9	0.9	1.2
Novel to familiar place preference ratio	0.3	0.3	0.7	0.0	-0.4	-0.8	-0.6
Novelty place preference	0.3	0.3	0.8	-0.2	-0.2	-0.9	-0.4
Time in novel zone, NPP test	0.5	0.6	1.7	-0.6	-0.0	-1.3	-0.5
Total zone transitions, NPP test	1.1	1.6	3.4	-1.9	1.2	0.6	1.1
Total locomotion distance, NPP test	0.9	1.2	2.5	-1.6	0.6	1.1	0.7
Locomotion velocity, NPP test	0.9	1.2	3.1	-1.1	0.4	1.8	0.7
Intraocular pressure	4.3	5.9	9.3	-2.5	2.5	-3.0	1.5
Delta distance traveled before/after self-admin	1.1	1.1	2.7	-1.7	1.0	0.5	0.8
Delta ambulatory time before/after self-admin	0.7	0.8	2.7	-1.6	0.7	-0.1	0.3
Parametrial fat weight	6.4	12.4	23.8	-4.9	2.7	-4.0	1.5
Pavlov. Cond. lever latency	0.1	0.1	0.2	-0.3	-0.2	-0.4	-0.5
Pavlov. Cond. magazine entry latency	0.4	0.6	0.8	-0.9	0.6	0.6	0.8
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	-0.2	0.0	0.5	0.1
Pavlov. Cond. index score	0.3	0.4	0.5	-0.7	0.6	0.4	0.7
Pavlov. Cond. latency score	0.2	0.3	0.3	-0.6	0.5	0.3	0.6
Pavlov. Cond. lever contacts	0.0	0.0	0.0	0.2	0.2	-0.2	0.1
Pavlov. Cond. magazine entry number	1.1	1.3	1.8	1.3	-1.3	-0.2	-1.3
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.5	-0.2	0.7	-0.7	0.4
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.4	-0.6	0.5	0.3	0.5
Pavlov. Cond. response bias	0.5	0.6	1.0	-0.6	0.9	0.4	1.0
Pavlov. Cond. lever latency	0.7	0.9	2.8	0.8	-0.4	1.7	0.3
Pavlov. Cond. magazine entry latency	0.7	0.8	2.7	-1.7	0.6	-0.4	0.3
Pavlov. Cond. change in total contacts	1.2	1.6	3.6	-1.2	1.1	-1.9	0.2
Pavlov. Cond. index score	1.3	1.6	2.8	-1.7	1.2	-1.4	0.5
Pavlov. Cond. latency score	1.1	1.4	2.8	-1.7	1.0	-1.3	0.4
Pavlov. Cond. lever contacts	0.5	0.7	1.2	-1.0	0.7	-1.1	0.4
Pavlov. Cond. magazine entry number	0.7	0.8	2.6	1.6	-0.7	0.4	-0.4
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.1	-0.3	-0.1	-0.0	-0.1
Pavlov. Cond. lever-magazine prob. diff.	1.3	1.6	2.6	-1.6	1.3	-1.3	0.7
Pavlov. Cond. response bias	0.9	1.2	2.1	-1.4	0.9	-1.2	0.5
Time in closed arm before self-admin	0.2	0.2	0.4	-0.5	-0.3	0.6	-0.5
Time in closed arm after self-admin	0.6	0.6	1.8	0.3	-0.5	1.3	-0.3
Time in open arm before self-admin	1.3	1.4	2.6	1.6	-1.3	0.9	-0.8
Time in open arm after self-admin	0.4	0.4	0.7	0.8	-0.5	-0.8	-0.5
Bone: periosteal estimation	4.7	9.7	20.9	-4.6	3.0	-2.2	2.0
Bone: periosteal perimeter	8.8	14.6	24.0	-4.9	4.1	-3.1	2.9
Bone: post-yield work	0.2	0.3	0.4	-0.6	-0.5	-0.2	-0.6
Progressive ratio test 1 active lever presses	2.1	2.2	4.2	-1.0	2.1	-0.1	1.9
Progressive ratio test 1 breakpoint	1.0	1.1	2.2	-0.4	1.5	-0.3	1.3
Progressive ratio test 1 inactive lever presses	0.5	0.5	0.9	-0.5	0.7	0.6	0.9
Progressive ratio test 2 active lever presses	3.2	3.5	5.6	-1.7	2.4	-0.9	2.2
Progressive ratio test 2 breakpoint	2.8	3.2	5.1	-1.6	2.3	-1.0	2.0
Progressive ratio test 2 inactive lever presses	0.9	1.1	1.4	-1.2	0.9	-1.1	0.8
Incentive Sensitization - Responses	1.5	1.6	1.9	-1.2	1.4	-1.2	1.2
Incentive Sensitization - Breakpoint	1.6	1.7	1.9	-1.2	1.4	-1.3	1.2
Sum of active levers in priming session hrs 5-6	2.2	2.2	2.7	1.6	-1.6	0.9	-1.6
Progressive ratio	0.4	0.4	1.4	1.2	-0.3	0.4	-0.4
Food seeking constrained by brief footshock	0.8	1.0	2.3	0.7	-1.1	0.5	-1.5
Seeking ratio, punishment vs. effort	0.2	0.2	0.4	-0.7	-0.4	0.2	-0.5
Retroperitoneal fat weight	9.2	30.3	63.8	-8.0	5.1	-3.9	4.1
Reaction time number correct	0.6	0.9	1.4	-1.2	0.6	-1.1	0.6
Reaction time mean minus median	0.9	1.2	2.9	-0.6	1.7	-0.4	1.3
Reaction time mean minus median AUC	1.2	1.6	2.7	-0.9	1.7	0.4	1.6
Reaction time num false alarms	0.0	0.1	0.2	-0.1	-0.2	0.0	-0.5
Reaction time num false alarms AUC	0.0	0.0	0.0	-0.2	0.1	0.2	0.1
Reaction time trials correct on left	0.6	0.9	1.4	-1.2	0.6	-1.1	0.6
Reaction time trials on left	0.7	0.9	1.6	-1.3	0.6	-1.2	0.6
Reaction time mean	0.5	0.8	1.7	-0.0	1.3	-0.3	1.1
Reaction time mean AUC	0.2	0.3	0.7	0.4	0.8	-0.1	0.7
Median of all reaction times	0.4	0.6	1.2	0.1	1.0	-0.1	1.1
Reaction time omissions	0.3	0.4	0.9	-0.9	0.3	-0.6	0.3
Reaction time false alarm rate	0.1	0.2	0.2	0.5	-0.4	0.5	-0.5
Reaction time premature initiation rate	1.1	1.5	3.7	-0.6	1.4	0.2	1.9
Reaction time premature initiations	2.0	2.8	5.7	-1.4	1.9	-0.4	2.4
Std. dev. reaction times	2.2	3.1	5.5	-1.4	2.4	-0.9	2.0
Reaction time trials completed	0.7	0.9	1.6	-1.3	0.6	-1.2	0.6
Reaction time trials AUC	0.7	1.1	1.7	-1.3	0.7	-1.3	0.7
Run reversals in cocaine runway, females	0.8	0.8	1.3	-0.9	1.1	-0.5	0.9
Run reversals in cocaine runway, males	2.2	2.1	3.9	1.3	-2.0	1.2	-1.2
Latency to leave start box in cocaine runway	0.8	0.8	1.5	1.0	-0.7	1.2	-0.5
Latency to leave start box in cocaine runway, F	1.2	1.3	2.3	1.2	-1.0	1.5	-0.7
Latency to leave start box in cocaine runway, M	0.2	0.2	0.4	-0.5	0.5	-0.3	0.6
Std. dev. time between licks in bursts	0.2	0.3	0.7	-0.1	-0.5	-0.3	-0.8
Total sessions with >9 infusions	7.0	7.7	12.9	-2.3	3.6	-1.4	3.3
Short access day 1 total inactive lever presses	0.7	0.7	1.4	-1.2	0.6	0.7	0.8
Short access day 10 total inactive lever presses	0.5	0.5	1.0	-0.8	0.6	-1.0	0.4
Short access day 1 total infusions	1.2	1.3	2.3	-0.8	1.4	0.3	1.5
Short access day 10 total infusions	0.7	0.8	1.7	-0.1	1.3	0.0	1.1
Short access total infusions	1.2	1.4	2.8	-0.7	1.7	-0.3	1.5
Short access day 1 locomotion	1.3	1.4	2.8	-0.6	1.7	-0.4	1.5
Short access day 10 total locomotion	0.7	0.8	1.5	-1.0	0.8	0.5	1.2
Short access total locomotion	1.7	1.8	3.8	-0.7	1.7	0.3	2.0
One hour access (0.3 mA shock)	1.4	1.6	2.8	-1.7	1.2	-1.2	0.8
Compulsive drug intake	0.3	0.3	0.7	0.2	-0.7	0.1	-0.8
One hour access (shock baseline)	2.1	2.5	3.7	-1.5	1.9	-1.1	1.7
Social response proportion	2.9	3.2	4.8	-1.9	2.0	0.6	2.2
Social responses	4.5	5.7	8.1	-2.8	2.7	-1.8	2.1
Social time	1.5	2.0	3.2	-1.5	1.8	-0.2	1.6
Soleus weight	2.8	8.1	13.5	-3.7	3.1	-0.7	3.0
Bone: stiffness	1.5	2.4	3.6	-1.7	1.9	-0.9	1.5
Tibialis anterior weight	0.3	0.9	2.6	0.4	-0.3	-1.6	-0.9
Time to tail flick, vehicle, before self-admin	2.0	2.1	4.3	-1.3	1.3	-2.1	0.7
Time to tail flick, vehicle, after self-admin	0.3	0.3	0.6	0.1	0.8	-0.1	0.7
Time to tail flick, test, before self-admin	2.4	2.4	4.4	-0.8	1.9	0.9	2.1
Time to tail flick, test, after self-admin	1.9	1.9	2.7	-1.6	1.4	-1.6	0.8
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.3	0.4	-0.0	0.6	0.2
Delta time to tail flick, test, before/after SA	1.9	1.7	5.4	-1.1	0.5	-2.3	-0.2
Tibia length	1.7	4.7	7.7	-2.8	2.4	-0.3	2.3
Ambulatory time before self-admin	0.7	0.7	2.0	-0.3	0.3	1.4	0.8
Ambulatory time after self-admin	1.7	1.9	4.5	-1.0	0.7	2.1	1.2
Bone: tissue strength	0.3	0.3	0.7	0.4	-0.7	0.1	-0.8
Total heroin consumption	0.6	0.7	1.5	-1.2	0.3	-1.2	-0.2
Bone: trabecular number	0.8	1.2	2.2	-0.8	-0.4	-1.5	-1.4
Bone: trabecular spacing	0.1	0.1	0.3	0.5	-0.3	0.1	0.0
Bone: trabecular thickness	3.8	4.5	9.8	-3.1	1.8	-2.1	0.8
Bone: trabecular tissue density	1.0	1.4	2.9	-0.5	1.6	0.2	1.7
Water consumed over 24 hours	0.8	1.0	1.2	-0.9	0.8	1.1	1.1
Number of responses in last shaping day	0.2	0.2	0.4	-0.1	0.6	-0.1	0.5