Hub : Genes

Plekhs1

pleckstrin homology domain containing S1

chr1:265500524–265533352 (+)

Plekhs1 RatGTEx page

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Plekhs1 0.05 0.03 7.1e-06 0.05 0.06 0.04 0.05 3.5e-05 6.2e-06 1.3e-04 2.0e-05
2 IC gene expression Plekhs1 0.13 0.08 7.6e-05 0.13 0.04 0.1 0.1 5.2e-06 7.9e-03 8.3e-05 8.4e-05
3 IC alternative polyA NM_001134613.1 0.07 0.06 5.4e-03 0.03 0.01 0.01 0.01 1.7e-02 8.8e-02 1.7e-01 8.2e-02
4 IC alternative polyA XM_063271784.1 0.07 0.06 4.8e-03 0.04 0.02 0.01 0.02 1.3e-02 6.0e-02 1.2e-01 5.3e-02
5 Eye intron excision ratio chr1_265512639_265512749 0.45 0.2 7.1e-03 0.1 0.05 0 0.07 1.4e-02 6.9e-02 2.6e-01 3.7e-02
6 IL alternative TSS NM_001134613.1 0.21 0.15 8.7e-03 0.05 0.03 0.04 0.04 3.0e-02 6.8e-02 4.4e-02 3.4e-02
7 Liver gene expression Plekhs1 0.07 0.04 1.1e-07 0.07 0.05 0.06 0.06 5.0e-08 1.9e-06 1.0e-06 2.0e-07
8 Liver alternative polyA XM_063271784.1 0.44 0.11 0.0e+00 0.41 0.36 0.41 0.41 4.3e-49 2.0e-42 1.5e-48 2.9e-49
9 Liver alternative polyA NM_001134613.1 0.44 0.11 0.0e+00 0.41 0.36 0.41 0.41 2.6e-48 1.0e-41 3.2e-48 1.5e-48
10 Eye alternative polyA XM_063271784.1 0.64 0.15 1.6e-04 0.14 0.14 0.2 0.2 3.5e-03 4.2e-03 4.7e-04 5.7e-04
11 Eye alternative polyA NM_001134613.1 0.67 0.14 9.8e-05 0.14 0.14 0.21 0.19 4.1e-03 4.0e-03 4.1e-04 7.3e-04
12 NAcc alternative polyA XM_063271784.1 0.1 0.05 3.5e-13 0.1 0.08 0.09 0.09 1.4e-14 1.8e-12 3.8e-13 7.9e-14
13 Eye isoform ratio NM_001134613.1 0.8 0.11 4.2e-07 0.15 0.36 0.25 0.34 2.4e-03 1.6e-06 8.6e-05 3.1e-06
14 NAcc alternative polyA NM_001134613.1 0.09 0.05 2.6e-13 0.1 0.08 0.09 0.09 1.7e-14 2.2e-12 3.6e-13 9.5e-14
15 Liver isoform ratio NM_001134613.1 0.29 0.1 0.0e+00 0.32 0.26 0.31 0.31 9.2e-36 1.9e-28 1.4e-34 3.8e-35
16 BLA gene expression Plekhs1 0.1 0.06 3.1e-04 0.04 0.06 0.06 0.05 3.5e-03 3.1e-04 4.0e-04 8.4e-04
17 NAcc gene expression Plekhs1 0.05 0.03 1.5e-08 0.05 0.05 0.05 0.05 4.1e-08 6.1e-08 4.5e-08 3.9e-08
18 PL alternative polyA NM_001134613.1 0.05 0.03 3.1e-04 0.02 0.02 0.02 0.01 2.0e-03 1.3e-03 6.8e-03 7.5e-03
19 PL alternative polyA XM_063271784.1 0.05 0.03 1.7e-04 0.02 0.03 0.02 0.02 1.3e-03 5.7e-04 2.8e-03 3.0e-03
20 BLA alternative polyA NM_001134613.1 0.18 0.09 1.3e-06 0.09 0.1 0.08 0.1 1.2e-05 5.6e-06 5.1e-05 7.4e-06
21 BLA alternative polyA XM_063271784.1 0.17 0.09 1.3e-06 0.09 0.1 0.1 0.1 1.5e-05 5.3e-06 9.7e-06 7.8e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
Bone: apparent density0.61.05.21.60.9-0.70.72.2-2.30.20.10.0-0.20.20.00.30.10.1-0.9-1.50.9-0.91.0-1.1
Area under the delay curve0.10.10.40.4-0.3-0.30.30.5-0.5-0.20.1-0.00.1-0.00.10.3-0.20.1-0.3-0.30.6-0.60.6-0.7
BMI with tail3.411.746.76.85.9-4.84.82.1-2.1-3.23.5-3.33.3-3.33.3-3.4-3.2-3.02.00.7-1.51.5-1.31.2
BMI without tail2.88.426.75.24.7-4.04.00.9-0.9-3.13.1-2.93.0-3.02.8-3.0-2.7-2.72.11.2-1.71.7-1.51.4
Body weight3.213.960.57.86.3-5.55.53.4-3.4-3.83.7-3.53.4-3.43.1-3.4-3.0-3.11.5-0.1-1.11.1-1.00.8
Weight adjusted by age3.85.811.13.32.2-2.32.30.2-0.1-2.42.8-2.72.7-2.73.3-2.6-3.1-2.62.01.3-2.22.2-2.12.0
Bone surface0.20.41.71.20.9-0.70.71.3-1.30.2-0.10.1-0.10.10.00.00.10.2-0.4-0.90.4-0.40.6-0.6
Bone volume0.61.15.32.31.7-1.51.51.9-1.9-0.50.6-0.50.5-0.40.6-0.4-0.5-0.4-0.2-0.90.3-0.30.4-0.5
Breakpoint value in progressive ratio session0.20.30.90.2-0.6-0.40.40.8-0.70.1-0.10.1-0.20.2-0.40.50.60.1-0.3-0.50.8-0.80.9-0.9
Number of licking bursts0.30.61.50.4-0.2-0.10.11.1-1.20.2-0.40.4-0.40.4-0.70.70.60.5-0.8-1.01.1-1.11.1-1.2
Context. condit. distance diff. score0.30.41.0-0.90.30.0-0.0-1.00.80.5-0.90.9-0.70.7-0.90.30.90.8-0.10.10.2-0.30.10.0
Locomotion velocity, session 10.30.31.4-0.9-0.91.2-1.2-0.60.50.3-0.10.0-0.10.00.40.3-0.3-0.0-0.10.3-0.10.1-0.10.0
Locomotion distance, session 11.62.04.10.10.5-0.50.5-1.81.8-1.01.3-1.41.4-1.41.5-1.3-1.4-1.51.52.0-1.61.6-1.61.6
Locomotion velocity, session 21.82.14.80.01.0-1.01.0-2.22.2-1.21.0-1.01.2-1.21.2-1.4-1.2-1.11.62.1-1.71.7-1.81.8
Locomotion distance, session 22.13.04.51.41.5-1.91.9-1.11.3-1.81.8-1.81.8-1.82.1-1.8-2.1-1.82.11.9-1.51.5-1.41.3
Locomotion velocity, session 31.61.83.20.31.0-1.11.1-1.41.6-1.31.3-1.31.4-1.41.4-1.3-1.4-1.41.51.8-1.41.4-1.51.5
Locomotion distance, session 32.52.74.70.51.4-1.41.4-2.02.1-1.51.4-1.41.5-1.51.6-1.7-1.6-1.51.92.2-1.71.7-1.81.9
Stereotopy head waving bouts, day 30.10.10.30.1-0.20.2-0.20.5-0.3-0.50.3-0.30.4-0.40.3-0.1-0.2-0.2-0.0-0.1-0.10.1-0.20.1
Stereotopy head waving duration, day 30.50.61.7-0.6-1.21.3-1.31.1-1.00.3-0.40.4-0.30.3-0.50.80.50.5-1.1-0.90.5-0.50.5-0.5
Locomotion velocity, session 70.10.10.20.50.1-0.40.40.5-0.5-0.10.0-0.00.0-0.00.4-0.1-0.40.0-0.1-0.3-0.00.00.0-0.1
Locomotion distance, session 70.00.00.2-0.10.0-0.40.4-0.40.40.0-0.30.2-0.20.20.1-0.1-0.00.20.20.2-0.20.2-0.10.2
Stereotopy head waving bouts, day 70.00.00.30.10.2-0.10.10.5-0.30.1-0.20.2-0.10.1-0.10.10.10.2-0.1-0.40.1-0.20.2-0.3
Stereotopy head waving duration, day 70.10.21.00.70.5-0.10.11.0-0.9-0.30.3-0.20.3-0.30.3-0.0-0.3-0.1-0.3-0.50.1-0.10.2-0.3
Locomotion velocity, session 80.91.12.3-1.5-0.41.1-1.1-0.80.71.2-1.41.4-1.21.2-1.30.91.31.3-0.5-0.20.6-0.60.5-0.4
Locomotion distance, session 80.40.53.0-0.60.7-0.60.6-1.71.7-0.1-0.20.1-0.00.00.0-0.4-0.00.01.01.1-0.50.5-0.50.6
Degree of sensitization distance3.33.44.8-1.0-1.61.2-1.21.5-1.51.7-1.92.0-2.02.0-2.21.92.22.0-1.9-2.12.0-2.02.1-2.1
Degree of sensitization stereotypy0.20.20.50.10.10.1-0.10.7-0.60.5-0.40.4-0.40.4-0.20.30.20.4-0.3-0.60.5-0.50.6-0.6
Conditioned locomotion0.00.10.1-0.3-0.20.4-0.4-0.30.3-0.10.1-0.10.1-0.10.0-0.2-0.1-0.10.30.2-0.30.3-0.30.4
Cocaine response after cond. corrected1.01.25.7-1.3-0.70.4-0.4-2.22.4-0.20.3-0.40.4-0.40.2-0.6-0.3-0.61.41.7-1.21.2-1.11.2
Cocaine response after cond. not corrected0.70.83.7-1.7-1.10.7-0.7-1.81.90.2-0.20.1-0.10.1-0.4-0.10.3-0.10.81.1-0.70.7-0.70.8
Cocaine response before conditioning1.31.62.8-0.6-0.90.7-0.71.3-1.41.1-1.21.3-1.41.4-1.41.41.31.3-1.7-1.61.3-1.31.2-1.2
Saline control response0.40.61.3-0.6-0.70.0-0.0-1.11.1-0.40.6-0.60.6-0.70.4-0.6-0.4-0.70.81.1-1.11.1-1.11.0
Bone: connectivity density0.40.61.30.1-0.10.5-0.51.0-1.11.0-0.70.7-0.90.9-0.60.70.60.7-1.0-1.10.7-0.70.8-0.8
Bone: cortical apparent density2.73.78.9-0.50.6-1.01.0-3.02.7-1.61.5-1.51.6-1.61.5-1.8-1.5-1.72.12.6-2.42.4-2.62.7
Bone: cortical area3.24.817.84.23.3-3.13.11.8-1.9-2.32.4-2.32.3-2.22.2-1.8-2.2-2.10.90.1-0.70.7-0.60.4
Bone: cortical porosity0.30.30.5-0.2-0.7-0.10.10.7-0.40.1-0.60.7-0.40.5-0.50.50.50.7-0.4-0.60.7-0.70.7-0.7
Bone: cortical porosity0.60.71.60.2-0.4-0.20.21.3-1.10.3-0.70.8-0.60.6-0.70.70.70.9-0.7-1.11.1-1.11.2-1.2
Bone: cortical thickness2.74.410.73.32.8-2.92.90.7-0.8-2.42.4-2.32.4-2.42.3-2.0-2.3-2.21.30.8-1.31.3-1.21.1
Bone: cortical thickness2.12.45.32.22.2-2.32.30.0-0.2-1.71.5-1.41.6-1.51.7-1.7-1.7-1.31.30.8-1.21.2-1.21.2
Bone: cortical tissue density2.43.38.9-0.70.4-0.80.8-3.02.7-1.41.3-1.41.4-1.41.3-1.7-1.4-1.52.02.5-2.32.3-2.52.6
Condit. Reinf. active minus inactive responses0.30.30.8-0.1-0.1-0.20.2-0.70.6-0.40.8-0.80.6-0.60.4-0.4-0.5-0.90.60.8-0.50.5-0.50.5
Condit. Reinf. active-inactive response ratio0.10.10.2-0.2-0.30.3-0.3-0.20.20.30.3-0.40.1-0.1-0.0-0.0-0.0-0.40.10.2-0.10.1-0.20.2
Condit. Reinf. active responses0.60.71.80.80.2-0.40.4-0.00.0-0.91.3-1.31.1-1.11.1-0.7-1.1-1.30.60.7-0.70.7-0.60.5
Condit. Reinf. inactive responses0.50.71.61.10.1-0.30.30.7-0.6-1.01.2-1.11.1-1.11.3-0.5-1.3-1.10.20.2-0.50.5-0.30.2
Incentive salience index mean0.40.41.0-0.4-0.6-0.00.0-1.00.9-0.30.7-0.70.6-0.60.7-0.4-0.7-0.80.81.0-0.70.7-0.70.6
Condit. Reinf. lever presses0.20.30.7-0.5-0.90.2-0.2-0.70.6-0.10.4-0.40.4-0.40.7-0.3-0.7-0.50.50.7-0.60.6-0.50.5
Condit. Reinf. active minus inactive responses0.70.94.70.7-1.00.7-0.72.2-2.20.00.6-0.50.4-0.40.30.6-0.3-0.4-1.1-1.20.6-0.60.7-0.9
Condit. Reinf. active-inactive response ratio0.40.51.60.0-0.81.0-1.01.3-1.20.6-0.20.2-0.20.2-0.00.70.00.2-0.9-0.90.6-0.60.8-0.8
Condit. Reinf. active responses1.01.37.71.4-0.80.1-0.12.7-2.8-0.51.1-1.00.8-0.80.60.3-0.6-0.8-1.1-1.40.6-0.60.6-0.8
Condit. Reinf. inactive responses0.50.73.81.0-0.5-0.50.51.9-1.9-0.71.0-0.90.8-0.80.30.1-0.4-0.8-0.7-0.90.4-0.40.2-0.3
Condit. Reinf. lever presses0.20.31.80.7-0.1-0.10.11.2-1.3-0.20.3-0.30.2-0.20.20.3-0.2-0.2-0.5-0.80.7-0.70.7-0.8
Condit. Reinf. lever reinforcers received0.71.05.51.1-0.80.2-0.22.3-2.4-0.41.0-0.90.7-0.80.50.3-0.6-0.7-0.9-1.20.5-0.50.6-0.8
Conditioned reinforcement - actives0.81.32.5-0.1-0.8-0.80.8-1.21.0-1.41.3-1.31.3-1.41.3-0.9-1.2-1.41.61.4-1.01.0-1.00.9
Conditioned reinforcement - inactives0.20.31.20.6-0.5-0.60.60.3-0.7-1.10.9-0.80.7-0.70.6-0.4-0.5-0.70.4-0.1-0.20.2-0.20.1
Conditioned locomotion2.22.85.20.20.1-1.41.4-1.61.8-1.81.6-1.71.7-1.81.9-1.7-1.7-1.82.32.2-1.81.8-1.71.7
Patch foraging indifference point 0 sec0.81.56.32.51.7-1.31.31.4-1.2-1.41.2-1.11.1-1.11.6-1.0-1.7-1.00.4-0.1-0.50.5-0.30.2
Patch foraging indifference point AUC0.30.51.4-0.2-0.70.5-0.50.8-0.90.5-0.50.5-0.50.5-0.40.80.50.6-0.6-0.80.9-0.91.1-1.2
Delay disc. indifference point, 0s delay0.30.41.40.70.5-1.21.2-0.20.4-1.10.6-0.50.6-0.60.3-0.5-0.4-0.50.60.5-0.10.1-0.10.1
Delay disc. indifference point, 16s delay0.20.20.8-0.2-0.70.2-0.2-0.0-0.20.2-0.30.3-0.30.3-0.10.60.20.4-0.5-0.30.8-0.80.8-0.9
Delay disc. indifference point, 2s delay0.20.20.5-0.3-0.4-0.40.4-0.30.30.2-0.70.7-0.50.5-0.60.30.50.7-0.0-0.10.5-0.50.4-0.4
Delay disc. indifference point, 24s delay1.01.12.70.1-0.40.4-0.41.2-1.40.8-0.80.8-0.80.9-0.61.20.80.9-1.3-1.21.6-1.61.6-1.6
Delay disc. indifference point, 4s delay0.20.20.6-0.3-0.40.3-0.3-0.1-0.00.1-0.50.5-0.50.5-0.60.60.50.5-0.4-0.30.8-0.80.8-0.7
Delay disc. indifference point, 8s delay1.11.23.31.80.6-1.01.01.1-0.9-1.31.5-1.41.4-1.41.6-0.8-1.6-1.30.50.2-0.40.4-0.30.1
Indifference point function ln k0.10.10.50.20.20.1-0.1-0.20.2-0.10.1-0.10.2-0.20.4-0.4-0.4-0.10.10.2-0.60.6-0.70.7
Indifference point function log k0.10.10.50.20.20.1-0.1-0.20.2-0.10.1-0.10.2-0.20.4-0.4-0.4-0.10.10.2-0.60.6-0.70.7
Patch foraging total patch changes 0 sec0.71.35.82.41.6-1.21.21.5-1.5-1.21.1-1.01.0-1.01.5-0.8-1.6-0.80.2-0.4-0.20.3-0.10.0
Patch foraging total patch changes 12 sec0.30.41.90.80.60.0-0.01.2-1.40.0-0.20.3-0.20.2-0.10.4-0.00.4-0.6-1.00.8-0.81.0-1.0
Patch foraging total patch changes 18 sec0.50.73.81.50.2-0.20.22.0-1.9-0.50.4-0.40.3-0.30.70.1-0.7-0.2-0.5-1.00.6-0.60.9-1.0
Patch foraging total patch changes 24 sec0.40.63.71.00.1-0.40.41.7-1.9-0.40.3-0.20.2-0.20.30.4-0.4-0.1-0.6-1.10.8-0.81.0-1.1
Patch foraging total patch changes 6 sec1.11.77.12.71.5-1.51.51.8-1.9-1.41.4-1.31.3-1.31.5-0.9-1.5-1.10.3-0.5-0.20.2-0.0-0.1
Patch foraging time to switch 0 sec0.10.10.7-0.9-0.2-0.20.2-0.70.8-0.0-0.20.1-0.20.2-0.60.10.30.10.20.4-0.10.1-0.20.3
Patch foraging water rate 0 sec0.10.21.11.00.8-0.00.00.6-0.8-0.40.5-0.50.5-0.50.7-0.4-0.5-0.4-0.1-0.2-0.30.3-0.20.2
Patch foraging water rate 12 sec0.20.52.81.20.40.1-0.11.4-1.70.10.10.0-0.10.1-0.10.30.20.1-1.1-1.20.5-0.50.6-0.6
Patch foraging water rate 18 sec0.61.01.51.10.8-1.11.1-0.50.4-1.21.0-0.91.0-1.01.2-1.1-1.0-0.91.00.8-1.01.0-1.00.9
Patch foraging water rate 24 sec0.91.33.21.71.8-1.21.2-0.60.5-1.21.1-1.11.2-1.21.2-1.3-1.1-1.11.30.9-0.90.9-0.70.7
Patch foraging water rate 6 sec0.71.02.61.01.6-1.01.0-0.70.5-1.61.0-1.01.1-1.10.9-1.0-0.9-0.90.90.9-0.90.9-0.90.9
Seeking ratio, delayed vs. immediate footshock0.10.21.0-0.50.1-0.30.3-1.01.00.2-0.30.3-0.10.1-0.0-0.20.10.20.60.6-0.20.1-0.10.1
Distance traveled before self-admin0.91.23.2-0.20.7-0.40.4-1.81.7-0.70.6-0.70.7-0.71.0-1.2-0.8-0.71.31.5-1.41.4-1.61.7
Distance traveled after self-admin1.92.34.70.41.1-1.61.6-1.92.2-1.41.1-1.21.2-1.21.4-1.6-1.5-1.22.12.0-1.51.5-1.61.6
Extensor digitorum longus weight0.10.52.30.90.5-0.40.41.3-1.50.5-0.40.5-0.50.50.00.4-0.00.6-0.8-1.00.8-0.80.8-0.9
Bone: elastic displacement0.10.10.2-0.2-0.20.2-0.20.3-0.30.4-0.50.5-0.40.4-0.20.40.30.5-0.3-0.40.5-0.50.5-0.5
Bone: elastic work1.72.24.21.62.0-1.91.9-0.80.8-1.41.3-1.31.5-1.41.5-1.7-1.5-1.31.61.4-1.31.3-1.31.3
Bone: endosteal estimation0.40.84.22.01.7-1.41.41.3-1.3-0.80.3-0.30.5-0.50.4-0.5-0.3-0.10.2-0.50.2-0.20.4-0.4
Bone: endosteal perimeter2.04.213.63.73.1-2.72.71.2-1.2-2.22.3-2.22.1-2.12.2-2.0-2.2-2.11.20.5-1.01.1-0.90.8
Epididymis fat weight2.79.144.16.64.5-3.73.74.8-4.9-2.52.8-2.52.3-2.32.2-1.7-2.3-2.2-0.4-1.80.3-0.30.4-0.6
Delta time in closed arm before/after self-admin0.60.50.90.1-0.0-0.80.8-0.70.8-0.90.8-0.80.8-0.80.5-0.7-0.6-0.80.90.9-0.70.7-0.80.8
Delta time in open arm before/after self-admin0.30.31.50.5-0.10.2-0.21.2-1.00.2-0.10.1-0.20.2-0.00.4-0.00.2-0.6-0.70.6-0.60.7-0.8
Diff in mean of infusions in LGA sessions1.01.22.4-1.3-0.51.0-1.0-0.40.21.4-1.51.5-1.31.3-1.41.21.51.5-0.9-0.50.9-0.90.9-0.9
Delay discount exponential model param0.10.20.5-0.40.30.3-0.3-0.60.60.2-0.0-0.0-0.0-0.0-0.1-0.30.2-0.10.30.3-0.70.7-0.70.7
Extinction: sum of active levers before priming0.91.04.9-1.1-2.20.6-0.60.7-0.20.8-0.90.8-0.80.8-1.21.11.10.8-0.8-0.61.1-1.11.1-1.2
Active lever presses in extinction session 60.40.41.20.4-0.2-1.11.1-0.30.4-0.70.9-0.90.9-0.90.2-0.5-0.4-0.90.60.7-0.20.3-0.40.4
Bone: final force1.62.56.12.52.0-2.32.30.2-0.2-1.71.6-1.61.7-1.71.7-1.7-1.7-1.51.30.9-1.21.2-1.00.9
Bone: final moment1.42.36.72.62.2-2.42.40.3-0.3-1.61.4-1.41.6-1.51.6-1.6-1.6-1.31.30.8-1.01.0-0.80.7
Food consumed during 24 hour testing period0.10.10.50.00.6-0.10.1-0.70.50.2-0.20.2-0.20.2-0.3-0.10.50.10.10.40.0-0.0-0.20.2
Glucose1.21.94.82.22.2-1.81.80.6-0.9-1.31.5-1.51.3-1.31.4-1.4-1.3-1.40.60.3-1.11.1-1.11.1
Heart weight0.61.05.12.31.8-1.11.11.2-1.4-1.00.9-0.80.8-0.80.9-0.7-0.8-0.70.1-0.5-0.10.10.0-0.1
Delay discount hyperbolic model param0.10.10.3-0.40.20.4-0.4-0.30.40.3-0.00.0-0.10.0-0.1-0.20.2-0.10.20.2-0.50.5-0.50.6
Intermittent access intake day 1-15 change1.42.85.11.91.0-2.02.0-0.20.3-2.32.1-2.02.0-2.01.7-1.9-1.5-1.91.71.2-1.51.5-1.61.5
Intermittent access intake escalation1.02.04.31.80.8-1.61.60.2-0.1-2.11.8-1.81.7-1.71.3-1.5-1.3-1.71.20.8-1.11.1-1.21.2
Intermittent access intake escalation 21.92.24.11.40.8-1.71.7-0.40.7-2.01.7-1.71.7-1.71.5-1.7-1.3-1.71.61.3-1.41.4-1.41.4
Intermitt. access day 1 inactive lever presses0.20.93.71.20.1-0.20.21.9-1.70.2-0.20.3-0.40.4-0.20.60.20.5-0.9-1.31.2-1.21.3-1.4
Intermitt. access day 15 inactive lever presses0.00.10.50.2-0.7-0.20.20.3-0.2-0.40.3-0.30.3-0.30.2-0.0-0.1-0.30.10.10.1-0.10.1-0.2
Intermitt. access escalation Index0.00.00.20.00.5-0.10.10.3-0.40.0-0.10.1-0.20.2-0.10.0-0.10.1-0.1-0.40.2-0.20.1-0.0
Intermittent access day 1 total infusions0.40.71.30.3-0.8-1.11.1-0.20.3-1.11.0-1.01.0-1.01.1-0.6-1.1-0.91.10.6-0.40.4-0.40.3
Intermittent access day 15 total infusions0.81.23.00.8-0.6-1.51.50.00.2-1.71.4-1.41.4-1.41.2-1.1-1.1-1.31.30.8-0.70.7-0.80.7
Intermittent access terminal intake (last 3 days)0.50.71.80.5-0.3-1.11.1-0.10.2-1.31.0-0.91.0-1.00.8-0.8-0.6-0.91.10.6-0.60.6-0.60.5
Intermittent access total infusions1.21.42.70.9-0.6-1.31.30.00.0-1.61.5-1.51.5-1.51.6-1.1-1.5-1.51.40.7-0.90.9-0.80.7
Intermittent access day 1 locomotion1.01.32.40.4-0.1-1.41.4-1.11.1-1.31.0-1.11.2-1.21.2-1.1-1.1-1.11.61.4-1.11.1-1.00.9
Intermittent access day 15 total locomotion0.81.43.81.90.9-1.31.30.6-0.7-1.51.6-1.51.4-1.41.4-1.2-1.0-1.40.70.3-0.80.8-0.80.7
Intermittent access total locomotion2.42.93.71.30.9-1.81.8-1.11.1-1.91.8-1.81.9-1.81.9-1.9-1.7-1.81.91.7-1.81.8-1.81.7
Intermittent access standard deviation0.10.30.90.8-0.2-0.60.61.0-0.7-0.80.7-0.60.5-0.50.5-0.2-0.4-0.50.2-0.30.1-0.10.1-0.2
Left kidney weight1.57.020.83.74.6-4.24.2-0.60.7-2.72.4-2.32.4-2.42.2-3.0-2.0-2.22.71.8-1.91.9-1.91.9
Right kidney weight2.812.727.74.95.1-5.35.3-0.80.9-3.43.4-3.43.5-3.43.5-4.1-3.2-3.33.52.7-2.92.9-2.82.8
Cocaine induced anxiety1.11.55.1-2.3-0.90.6-0.6-2.21.81.4-1.51.3-1.21.3-1.60.81.71.20.10.50.3-0.40.3-0.2
Post-drug Anxiety0.70.82.1-0.7-0.10.4-0.4-0.3-0.11.1-1.11.0-1.01.1-1.40.81.41.0-0.7-0.60.9-0.90.9-0.8
Baseline Anxiety0.70.85.21.70.3-0.00.02.3-2.1-0.40.5-0.40.3-0.30.50.1-0.5-0.3-0.9-1.10.5-0.50.5-0.6
Tail length0.10.31.01.00.8-1.01.00.5-0.6-0.80.4-0.30.4-0.40.1-0.3-0.1-0.30.2-0.10.1-0.10.1-0.1
Length with tail0.41.98.32.92.2-2.12.11.7-1.8-1.71.3-1.21.2-1.10.9-1.0-0.8-1.00.3-0.4-0.10.1-0.10.1
Length without tail1.13.516.14.02.6-2.62.63.0-2.9-1.71.6-1.51.3-1.31.4-1.1-1.2-1.3-0.1-1.10.3-0.30.2-0.3
LgA early post infusion interval0.30.41.0-1.0-0.40.3-0.3-0.60.20.8-0.90.9-0.80.8-0.70.60.80.9-0.3-0.30.5-0.50.5-0.5
LgA late post infusion interval1.21.42.7-1.2-1.71.5-1.50.5-0.61.3-1.21.2-1.21.2-1.01.40.91.2-1.2-1.11.1-1.11.2-1.2
LgA early loading1.42.56.4-0.4-1.71.7-1.72.5-2.31.2-0.91.0-1.21.2-1.01.71.11.1-2.2-2.11.7-1.71.6-1.7
LgA late loading0.71.72.61.00.9-1.31.3-0.40.8-1.31.6-1.61.5-1.61.4-1.3-1.4-1.61.21.3-1.11.1-1.41.4
LgA early average infusions1.82.25.0-0.5-1.71.9-1.92.2-1.91.3-0.91.0-1.21.1-1.11.61.11.0-2.1-1.91.4-1.41.3-1.3
LgA late average infusions0.60.82.61.61.2-1.31.30.7-0.5-0.91.1-1.11.0-1.00.9-0.8-1.0-1.00.40.2-0.30.3-0.40.4
LgA early timeout0.20.31.60.7-0.30.3-0.31.3-0.8-0.10.6-0.60.4-0.50.5-0.0-0.5-0.6-0.4-0.40.1-0.10.0-0.1
LgA late timeout1.82.43.41.61.5-1.61.6-0.60.8-1.61.7-1.71.6-1.61.6-1.7-1.8-1.71.61.4-1.51.5-1.51.5
LgA early titration0.91.34.30.0-1.01.0-1.02.1-1.71.0-0.70.7-0.90.9-0.81.10.80.7-1.6-1.51.2-1.21.1-1.1
LgA late titration0.40.73.21.81.4-0.90.91.3-1.4-0.60.8-0.70.6-0.60.7-0.4-0.6-0.6-0.3-0.50.1-0.1-0.0-0.0
LgA total infusion0.20.32.11.20.4-0.30.31.5-1.0-0.30.6-0.50.4-0.40.5-0.2-0.5-0.5-0.4-0.40.1-0.10.0-0.1
Times rat made contact with spout0.60.71.50.90.7-1.21.2-0.50.6-1.00.8-0.80.8-0.80.9-0.9-0.8-0.81.10.8-0.50.5-0.50.5
Lifetime Intake1.62.03.71.1-0.3-1.51.5-0.20.2-1.91.8-1.81.8-1.81.8-1.3-1.8-1.71.60.9-1.11.1-1.00.9
Liver weight, left1.52.511.83.43.0-2.62.61.7-1.7-1.41.2-1.11.1-1.01.2-1.3-0.9-1.00.6-0.4-0.10.1-0.10.0
Liver weight, right4.07.015.93.93.5-4.04.0-0.40.7-2.92.5-2.42.5-2.52.6-3.0-2.6-2.32.81.9-2.02.0-1.81.7
Locomotor activity1.52.33.41.81.7-1.91.9-0.20.3-1.41.7-1.61.6-1.71.5-1.7-1.6-1.61.21.0-1.41.4-1.61.6
Locomotor testing distance2.74.86.31.82.1-2.12.1-1.21.1-2.32.5-2.52.4-2.52.1-2.4-2.2-2.52.11.9-2.32.3-2.52.4
Locomotor testing rearing1.12.33.71.51.9-1.71.7-0.80.8-1.81.6-1.61.6-1.61.1-1.7-1.0-1.61.51.4-1.41.4-1.61.6
Locomotion in novel chamber1.31.74.30.11.1-1.41.4-2.12.1-0.90.8-0.90.9-0.90.9-1.3-1.0-1.01.71.8-1.31.3-1.31.4
Locomotion in novel chamber post-restriction0.40.73.3-1.2-0.70.2-0.2-1.81.70.00.2-0.30.3-0.30.3-0.4-0.3-0.40.91.2-1.01.0-0.90.9
Fecal boli incidents, locomotor time 10.30.41.20.50.10.7-0.70.6-0.8-0.40.8-0.70.6-0.61.1-0.2-0.8-0.6-0.4-0.3-0.50.5-0.50.4
Change in fecal boli incidents, locomotor task1.21.22.5-1.1-0.80.3-0.3-0.60.71.5-1.51.4-1.41.4-1.60.81.51.3-0.3-0.01.0-1.01.0-0.9
Time >=10cm from walls, locomotor time 11.21.22.2-1.5-1.21.5-1.50.4-0.11.2-1.31.3-1.31.3-1.31.11.41.3-0.8-0.90.8-0.80.8-0.7
Bouts of movement, locomotor time 10.30.41.60.80.4-0.00.00.9-1.20.1-0.00.1-0.20.20.00.40.20.2-0.5-0.80.8-0.81.0-1.1
Total resting periods, locomotor time 10.20.20.90.70.5-0.20.20.6-0.9-0.00.00.0-0.10.10.10.20.10.1-0.1-0.50.6-0.60.8-0.9
Rest time, locomotor task time 10.81.01.80.70.8-0.80.8-1.00.7-1.01.1-1.11.1-1.11.0-1.1-0.9-1.11.41.2-1.01.0-0.80.7
Distance moved, locomotor task time 10.20.20.6-0.2-0.10.3-0.30.4-0.40.5-0.40.4-0.50.5-0.50.50.40.5-0.8-0.60.7-0.60.4-0.4
Vertical activity count, locomotor time 10.10.20.8-0.60.50.3-0.3-0.50.30.5-0.60.5-0.50.5-0.90.30.60.5-0.4-0.10.1-0.1-0.10.2
Time >=10cm from walls, locomotor time 20.50.83.20.2-0.20.1-0.11.8-1.20.4-0.70.7-0.80.8-0.90.71.00.8-0.8-1.31.1-1.11.0-1.0
Bouts of movement, locomotor time 20.81.33.1-1.5-0.30.4-0.4-0.80.91.3-1.81.7-1.61.6-1.11.11.31.6-0.5-0.11.0-1.01.0-1.0
Total resting periods, locomotor time 20.40.81.8-1.10.00.1-0.1-1.00.90.9-1.41.3-1.21.2-0.70.80.91.2-0.20.10.8-0.80.8-0.8
Rest time, locomotor task time 20.40.50.80.40.8-0.50.5-0.80.4-0.50.7-0.70.8-0.70.8-0.7-0.8-0.80.60.8-0.80.8-0.90.9
Distance moved, locomotor task time 20.30.31.50.0-0.80.2-0.21.2-0.80.3-0.20.2-0.20.2-0.10.50.10.3-0.6-0.80.6-0.60.7-0.7
Vertical activity count, locomotor time 20.10.10.90.30.50.2-0.21.0-0.7-0.10.0-0.0-0.10.0-0.20.20.20.1-0.4-0.60.3-0.30.3-0.4
Light reinforcement 10.40.92.7-1.6-1.00.8-0.8-0.80.81.0-1.41.4-1.11.1-0.60.90.71.2-0.2-0.00.7-0.70.7-0.6
Light reinforcement 20.60.93.4-1.8-1.10.5-0.5-1.41.51.0-1.31.3-1.11.1-0.90.70.71.10.10.40.4-0.40.4-0.4
Bone: marrow area0.40.84.32.11.7-1.41.41.3-1.3-0.80.3-0.30.5-0.50.4-0.6-0.3-0.10.2-0.50.2-0.20.4-0.4
Bone: maximum diameter2.24.117.84.23.1-2.82.82.4-2.4-1.92.0-1.91.8-1.82.0-1.5-2.0-1.70.4-0.5-0.20.2-0.1-0.1
Bone: maximum force1.22.15.42.32.1-2.12.10.3-0.4-1.61.4-1.31.6-1.51.4-1.5-1.4-1.21.10.7-1.01.0-0.90.8
Bone: maximum moment1.01.85.62.42.1-2.22.20.5-0.5-1.51.2-1.11.4-1.31.3-1.4-1.3-1.01.00.5-0.80.8-0.60.6
Mean time between licks in bursts0.20.50.9-0.2-0.50.5-0.50.8-0.80.5-0.60.6-0.60.6-0.80.80.70.6-0.8-0.91.0-1.00.9-0.9
Mean num. licks in bursts1.52.33.50.61.1-1.21.2-1.51.7-1.31.3-1.41.4-1.41.6-1.7-1.6-1.41.91.8-1.81.8-1.81.8
Cd content in liver1.11.24.0-0.30.6-0.80.8-2.02.0-0.60.4-0.50.6-0.60.5-1.1-0.5-0.61.41.6-1.41.4-1.51.6
Co content in liver0.50.61.4-0.4-0.30.9-0.9-1.11.2-0.20.4-0.40.4-0.40.8-0.5-0.7-0.50.50.9-1.11.1-1.01.0
Cu content in liver0.10.20.9-0.2-0.10.1-0.1-0.90.9-0.40.2-0.20.3-0.3-0.1-0.30.0-0.20.40.7-0.40.4-0.40.4
Fe content in liver0.50.61.80.4-0.20.6-0.61.3-1.20.50.1-0.0-0.40.4-0.40.90.40.0-1.2-1.01.1-1.11.1-1.2
K content in liver0.30.30.8-0.9-0.70.8-0.8-0.50.40.3-0.60.6-0.50.4-0.40.60.50.6-0.4-0.10.3-0.30.3-0.3
Mg content in liver0.50.50.9-0.8-0.50.7-0.7-0.30.30.5-0.90.9-0.70.7-0.90.70.90.9-0.4-0.30.7-0.70.7-0.7
Mn content in liver0.40.41.1-0.8-0.30.3-0.3-0.20.20.6-0.90.9-0.70.7-0.90.61.00.8-0.3-0.30.6-0.60.5-0.4
Na content in liver0.60.61.2-1.0-1.00.8-0.80.3-0.20.7-0.70.7-0.80.8-1.01.01.10.6-0.8-0.60.8-0.80.8-0.8
Rb content in liver2.73.15.5-1.9-2.01.9-1.90.4-0.51.6-1.81.8-1.81.8-2.31.92.31.8-1.6-1.41.8-1.81.7-1.7
Se content in liver0.50.61.4-1.2-0.71.0-1.0-0.30.20.8-0.80.8-0.80.8-1.00.91.10.7-0.8-0.40.6-0.60.5-0.5
Sr content in liver0.80.73.8-1.3-0.50.4-0.4-1.91.90.4-0.60.5-0.50.5-0.4-0.10.40.40.71.0-0.50.5-0.50.6
Zn content in liver0.40.52.5-1.1-0.30.4-0.4-1.61.50.5-0.70.7-0.50.5-0.60.10.50.60.30.7-0.20.2-0.20.2
Bone: minimum diameter0.91.67.92.82.2-1.91.91.7-1.7-1.21.0-0.90.9-0.90.7-0.7-0.6-0.70.1-0.60.3-0.30.4-0.5
Time in familiar zone, hab. session 10.20.20.8-0.1-0.10.1-0.1-0.40.3-0.20.4-0.40.3-0.30.6-0.4-0.6-0.40.20.4-0.80.8-0.90.9
Time in novel zone, hab. session 10.40.41.10.60.3-0.30.31.0-0.80.1-0.20.2-0.20.3-0.50.40.50.3-0.5-0.71.0-1.01.0-1.0
Total zone transitions, hab. session 11.92.64.41.71.9-2.12.1-0.60.8-1.81.7-1.71.7-1.71.7-1.7-1.7-1.71.71.5-1.31.3-1.31.2
Total locomotion distance, hab. session 10.00.10.30.00.4-0.50.5-0.20.4-0.20.1-0.10.1-0.00.0-0.00.1-0.10.30.30.3-0.30.2-0.2
Locomotion velocity, hab. session 10.10.10.3-0.20.3-0.40.4-0.40.6-0.1-0.10.00.00.0-0.0-0.00.20.00.40.40.2-0.20.2-0.2
Time in familiar zone, hab. session 21.01.06.21.1-0.30.2-0.22.5-2.10.6-0.00.1-0.30.3-0.20.60.10.1-0.9-1.51.1-1.11.2-1.3
Time in novel zone, hab. session 21.41.44.4-0.30.7-0.60.6-2.11.8-1.10.7-0.80.9-0.90.9-1.1-0.9-0.81.21.6-1.51.5-1.51.6
Total zone transitions, hab. session 22.22.84.51.72.0-2.12.1-0.91.1-1.71.7-1.81.8-1.81.7-1.7-1.7-1.81.71.8-1.31.3-1.21.2
Total locomotion distance, hab. session 20.70.92.01.01.4-1.41.4-0.70.9-1.11.0-1.01.0-1.00.7-1.0-0.6-1.01.21.1-0.50.5-0.50.5
Locomotion velocity, hab. session 20.50.71.70.71.2-1.31.3-0.80.9-0.90.8-0.80.8-0.80.5-0.8-0.4-0.81.11.1-0.50.5-0.50.5
Novel to familiar place preference ratio0.40.40.7-0.2-0.30.2-0.20.5-0.70.6-0.50.6-0.80.8-0.60.70.50.6-0.9-0.80.8-0.80.8-0.8
Novelty place preference0.30.30.70.0-0.10.1-0.10.7-0.80.5-0.40.5-0.70.7-0.50.60.40.5-0.7-0.80.7-0.70.7-0.7
Time in novel zone, NPP test0.50.51.40.3-0.00.0-0.01.1-1.20.5-0.40.4-0.70.7-0.50.70.40.5-0.9-1.11.0-1.01.0-1.0
Total zone transitions, NPP test0.81.22.91.31.7-1.71.7-0.70.9-1.10.9-0.91.1-1.11.0-1.1-1.0-1.01.41.3-0.50.5-0.40.4
Total locomotion distance, NPP test0.30.41.50.71.2-1.21.2-0.60.7-0.60.4-0.40.4-0.40.1-0.5-0.1-0.40.90.70.1-0.10.2-0.2
Locomotion velocity, NPP test0.30.51.30.31.1-1.21.2-1.01.1-0.50.3-0.30.4-0.40.0-0.6-0.1-0.41.11.0-0.10.1-0.10.2
Intraocular pressure1.42.05.52.30.9-1.21.21.6-1.5-1.42.1-2.01.7-1.71.8-1.0-1.8-1.90.4-0.1-0.50.5-0.30.1
Delta distance traveled before/after self-admin0.50.62.50.70.9-1.61.6-0.40.7-0.60.4-0.40.6-0.60.3-0.7-0.8-0.41.10.8-0.30.3-0.20.2
Delta ambulatory time before/after self-admin0.20.21.10.70.7-1.01.00.4-0.3-0.1-0.00.00.1-0.1-0.2-0.1-0.20.10.3-0.00.4-0.40.5-0.5
Parametrial fat weight2.45.728.95.42.9-2.42.44.3-4.1-1.72.1-1.91.7-1.72.3-1.3-2.2-1.7-0.2-1.60.2-0.20.5-0.8
Pavlov. Cond. lever latency0.30.41.50.1-0.20.5-0.51.2-1.20.5-0.20.3-0.40.4-0.50.50.50.3-0.7-1.10.7-0.70.7-0.7
Pavlov. Cond. magazine entry latency0.20.30.90.50.4-1.01.0-0.10.4-0.80.6-0.60.6-0.60.4-0.5-0.4-0.60.60.6-0.20.2-0.30.3
Pavlov. Cond. change in total contacts0.20.20.70.30.8-0.60.6-0.80.8-0.10.2-0.20.2-0.20.1-0.4-0.1-0.30.40.7-0.40.4-0.40.4
Pavlov. Cond. index score0.40.51.30.70.9-1.11.1-0.50.7-0.80.6-0.70.7-0.70.6-0.8-0.6-0.70.80.9-0.60.6-0.60.6
Pavlov. Cond. latency score0.40.51.00.60.8-1.01.0-0.60.8-0.70.6-0.60.6-0.60.6-0.7-0.6-0.60.80.9-0.70.7-0.60.6
Pavlov. Cond. lever contacts0.10.20.6-0.10.1-0.20.2-0.70.8-0.20.2-0.20.2-0.20.4-0.3-0.4-0.20.40.7-0.50.5-0.50.5
Pavlov. Cond. magazine entry number1.21.62.7-1.5-1.41.7-1.70.3-0.41.5-1.51.4-1.41.4-1.21.31.21.4-1.1-1.11.0-1.01.0-1.0
Pavlov. Cond. intertrial magazine entries0.20.20.50.40.1-0.00.0-0.40.3-0.30.6-0.60.5-0.50.7-0.5-0.6-0.60.40.5-0.60.6-0.50.4
Pavlov. Cond. lever-magazine prob. diff.0.20.30.80.50.7-0.90.9-0.40.5-0.60.5-0.50.5-0.50.4-0.5-0.4-0.50.50.7-0.40.4-0.40.4
Pavlov. Cond. response bias0.50.61.10.50.6-1.01.0-0.70.8-0.90.8-0.80.8-0.80.7-0.8-0.7-0.80.81.0-0.70.7-0.70.7
Pavlov. Cond. lever latency0.40.51.8-0.20.6-0.50.5-1.31.4-0.20.0-0.10.1-0.10.2-0.7-0.1-0.20.71.0-1.01.0-1.01.1
Pavlov. Cond. magazine entry latency0.30.41.21.11.0-0.80.80.9-1.0-0.10.1-0.00.0-0.00.10.1-0.10.0-0.2-0.60.7-0.70.7-0.7
Pavlov. Cond. change in total contacts0.30.52.60.7-0.50.3-0.31.6-1.6-0.20.6-0.50.4-0.40.20.3-0.2-0.4-0.5-0.90.7-0.70.8-0.9
Pavlov. Cond. index score0.30.41.71.00.3-0.40.41.3-1.3-0.40.6-0.50.4-0.40.40.1-0.4-0.4-0.2-0.60.7-0.70.7-0.8
Pavlov. Cond. latency score0.30.41.71.10.3-0.40.41.3-1.3-0.30.5-0.40.4-0.40.30.1-0.4-0.4-0.2-0.70.7-0.70.7-0.8
Pavlov. Cond. lever contacts0.10.20.70.4-0.20.1-0.10.8-0.9-0.20.2-0.20.2-0.20.10.2-0.2-0.1-0.2-0.50.6-0.60.6-0.7
Pavlov. Cond. magazine entry number0.30.30.9-1.0-0.80.7-0.7-0.91.00.2-0.20.2-0.20.2-0.2-0.00.10.10.10.5-0.70.7-0.60.7
Pavlov. Cond. intertrial magazine entries0.00.00.20.30.1-0.50.50.1-0.2-0.20.1-0.10.1-0.1-0.1-0.10.0-0.1-0.0-0.0-0.00.0-0.10.1
Pavlov. Cond. lever-magazine prob. diff.0.30.41.21.10.4-0.50.51.0-1.1-0.60.8-0.70.7-0.70.5-0.1-0.6-0.60.0-0.40.4-0.40.5-0.6
Pavlov. Cond. response bias0.30.41.70.70.1-0.10.11.2-1.3-0.10.2-0.20.2-0.20.10.3-0.1-0.1-0.4-0.80.8-0.80.8-0.9
LgA PC1 addiction-like behavior0.20.40.90.90.6-0.60.60.8-0.3-0.70.8-0.80.7-0.70.6-0.6-0.7-0.80.20.2-0.40.4-0.60.7
Time in closed arm before self-admin0.30.41.5-0.21.20.5-0.5-0.3-0.20.9-0.80.8-0.80.8-0.70.30.70.8-0.3-0.50.4-0.40.3-0.3
Time in closed arm after self-admin0.20.31.4-0.70.5-0.30.3-1.21.00.4-0.50.5-0.40.4-0.7-0.00.50.40.50.4-0.00.0-0.10.1
Time in open arm before self-admin0.50.62.1-1.4-1.50.8-0.8-0.20.50.5-0.70.7-0.60.6-1.10.91.10.6-0.6-0.10.6-0.60.5-0.5
Time in open arm after self-admin0.30.32.5-0.1-1.60.6-0.61.1-0.6-0.20.2-0.20.1-0.10.20.4-0.1-0.1-0.4-0.40.3-0.30.5-0.6
Bone: periosteal estimation1.73.615.23.93.1-2.92.91.7-1.7-2.11.8-1.71.9-1.81.7-1.6-1.6-1.50.9-0.1-0.50.5-0.30.2
Bone: periosteal perimeter4.06.822.64.83.5-3.53.51.8-1.8-2.83.1-2.92.8-2.72.9-2.4-2.9-2.71.30.4-1.21.2-1.10.9
Bone: post-yield work0.60.91.7-0.3-0.70.2-0.20.7-0.70.6-1.11.2-0.90.9-1.20.91.21.2-0.7-1.01.2-1.21.3-1.3
Progressive ratio test 1 active lever presses1.41.73.20.8-0.4-1.61.6-0.50.5-1.81.7-1.71.7-1.71.3-1.2-1.4-1.61.71.2-0.90.9-0.80.7
Progressive ratio test 1 breakpoint1.41.83.40.8-0.3-1.61.6-0.50.6-1.81.7-1.71.7-1.71.3-1.2-1.4-1.71.71.3-0.90.9-0.80.7
Progressive ratio test 1 inactive lever presses0.20.31.00.5-0.9-0.70.70.6-0.6-1.00.8-0.70.7-0.60.3-0.2-0.5-0.70.4-0.10.1-0.10.1-0.2
Progressive ratio test 2 active lever presses1.72.03.91.50.1-1.91.90.2-0.1-2.01.9-1.81.8-1.81.4-1.4-1.6-1.81.40.9-1.01.0-1.00.9
Progressive ratio test 2 breakpoint1.82.03.81.50.1-1.91.90.2-0.1-2.01.9-1.91.8-1.81.4-1.4-1.6-1.81.40.8-1.01.0-1.00.9
Progressive ratio test 2 inactive lever presses0.40.71.71.3-0.3-1.01.01.0-1.1-1.21.0-1.00.8-0.81.0-0.6-1.0-0.80.3-0.2-0.30.3-0.30.2
ShA PR total presses1.41.73.1-0.7-1.51.4-1.41.7-1.41.2-1.01.0-1.11.1-1.11.41.01.1-1.8-1.61.3-1.31.2-1.2
Incentive Sensitization - Responses0.40.51.51.20.2-1.11.10.8-0.8-0.80.9-0.90.8-0.80.6-0.6-0.7-0.80.2-0.1-0.30.3-0.40.3
Incentive Sensitization - Breakpoint0.30.51.41.20.1-0.90.90.9-0.8-0.70.9-0.80.7-0.70.5-0.5-0.6-0.80.2-0.2-0.30.3-0.40.3
LgA PR total presses0.10.10.6-0.7-0.50.4-0.4-0.40.80.20.0-0.10.1-0.10.1-0.1-0.0-0.20.20.4-0.30.3-0.50.6
Sum of active levers in priming session hrs 5-60.50.41.1-1.0-1.10.7-0.70.4-0.21.0-0.80.7-0.70.7-0.30.70.50.7-0.5-0.50.4-0.40.5-0.5
Progressive ratio0.20.31.7-1.0-1.30.6-0.60.10.20.2-0.10.1-0.20.2-0.60.70.50.1-0.4-0.10.5-0.50.4-0.4
Food seeking constrained by brief footshock1.62.03.1-1.1-1.11.0-1.01.0-1.01.4-1.31.3-1.41.4-1.71.61.61.3-1.5-1.51.8-1.81.5-1.5
Seeking ratio, punishment vs. effort0.10.20.80.50.9-0.50.50.2-0.30.4-0.50.5-0.40.5-0.1-0.10.10.5-0.0-0.40.2-0.20.1-0.1
Retroperitoneal fat weight2.510.957.17.65.1-4.04.05.2-5.2-2.52.9-2.62.4-2.42.5-2.0-2.5-2.2-0.2-1.90.3-0.30.5-0.8
Reaction time number correct0.10.21.11.00.4-0.30.31.0-1.1-0.40.00.00.1-0.00.1-0.0-0.00.1-0.3-0.70.3-0.30.4-0.4
Reaction time mean minus median0.61.42.80.80.4-1.01.0-0.00.4-1.51.6-1.61.6-1.61.2-1.2-1.2-1.71.20.9-1.11.1-1.21.1
Reaction time mean minus median AUC1.02.43.41.01.2-1.81.8-0.91.0-1.71.7-1.81.8-1.81.4-1.7-1.4-1.81.81.5-1.61.6-1.61.6
Reaction time num false alarms0.00.00.1-0.20.3-0.10.1-0.30.40.3-0.20.2-0.20.20.30.1-0.20.20.20.20.1-0.10.3-0.3
Reaction time num false alarms AUC0.10.10.40.00.4-0.50.5-0.60.7-0.20.1-0.10.2-0.20.5-0.2-0.5-0.20.50.6-0.20.2-0.10.1
Reaction time trials correct on left0.10.21.11.00.4-0.30.31.0-1.1-0.40.00.00.1-0.00.1-0.0-0.00.1-0.3-0.70.3-0.30.4-0.4
Reaction time trials on left0.10.21.21.10.4-0.40.41.1-1.1-0.40.1-0.00.1-0.10.1-0.1-0.10.1-0.3-0.70.3-0.30.4-0.4
Reaction time mean1.01.63.00.70.6-0.80.8-0.50.5-1.51.7-1.71.6-1.61.2-1.2-1.2-1.71.01.0-1.41.4-1.51.5
Reaction time mean AUC0.50.81.70.20.1-0.40.4-0.40.5-1.01.3-1.31.1-1.20.8-0.8-0.8-1.30.70.8-1.11.1-1.21.2
Median of all reaction times1.01.42.40.50.7-0.70.7-0.70.7-1.41.5-1.51.4-1.41.1-1.2-1.1-1.50.91.0-1.41.4-1.51.5
Reaction time omissions0.10.10.50.60.0-0.20.20.7-0.60.20.2-0.20.1-0.10.0-0.0-0.1-0.2-0.1-0.40.1-0.10.3-0.3
Reaction time false alarm rate0.10.10.7-0.6-0.1-0.00.0-0.70.80.2-0.10.1-0.10.10.20.1-0.3-0.00.30.5-0.10.10.0-0.0
Reaction time premature initiation rate1.82.44.10.81.4-1.41.4-1.11.2-2.01.5-1.51.7-1.61.7-1.6-1.8-1.51.71.6-1.71.7-1.61.6
Reaction time premature initiations1.62.95.61.61.7-1.81.8-0.60.7-2.41.8-1.71.9-1.92.0-1.8-2.0-1.71.71.4-1.61.6-1.61.5
Std. dev. reaction times1.63.05.61.71.0-1.71.70.00.1-2.22.4-2.32.3-2.31.8-1.7-1.8-2.31.41.1-1.51.5-1.51.4
Reaction time trials completed0.10.21.21.10.4-0.40.41.1-1.1-0.40.1-0.00.1-0.10.1-0.1-0.10.1-0.3-0.70.3-0.30.4-0.4
Reaction time trials AUC0.10.31.31.10.5-0.40.41.0-1.1-0.50.1-0.10.1-0.10.2-0.1-0.10.0-0.3-0.60.3-0.30.3-0.4
Run reversals in cocaine runway, females1.71.72.41.31.3-1.31.3-0.40.4-1.41.5-1.51.4-1.41.6-1.4-1.5-1.51.31.1-1.31.3-1.31.2
Run reversals in cocaine runway, males1.71.73.0-1.4-0.61.0-1.00.0-0.11.1-1.71.7-1.71.7-1.51.41.51.7-1.1-1.01.3-1.31.2-1.2
Latency to leave start box in cocaine runway0.20.31.1-1.1-0.40.4-0.4-1.10.90.4-0.50.5-0.40.4-0.50.50.50.4-0.10.30.2-0.20.1-0.1
Latency to leave start box in cocaine runway, F0.40.51.4-1.2-0.50.8-0.8-0.90.70.7-0.90.8-0.70.7-0.70.60.70.8-0.40.10.4-0.40.3-0.2
Latency to leave start box in cocaine runway, M0.10.10.70.10.1-0.80.8-0.40.3-0.50.4-0.40.4-0.40.0-0.2-0.0-0.40.30.30.0-0.0-0.10.0
Std. dev. time between licks in bursts0.60.91.8-0.7-1.11.1-1.10.4-0.30.8-1.01.0-0.90.9-0.81.00.81.0-0.5-0.71.1-1.11.3-1.3
Total sessions with >9 infusions3.34.07.02.00.9-2.12.1-0.20.0-2.62.6-2.62.6-2.62.2-2.0-2.3-2.52.01.2-1.71.7-1.61.5
Short access day 1 total inactive lever presses0.30.41.30.40.2-0.20.20.6-1.2-0.1-0.10.2-0.20.2-0.80.40.70.3-0.5-0.90.9-0.90.8-0.8
Short access day 10 total inactive lever presses0.10.21.10.91.1-0.70.70.1-0.3-0.70.4-0.40.4-0.40.4-0.5-0.6-0.30.30.1-0.10.1-0.20.2
Short access day 1 total infusions0.91.22.00.80.8-1.31.3-0.50.3-1.41.3-1.31.3-1.30.9-1.1-1.0-1.31.30.8-0.90.9-0.90.9
Short access day 10 total infusions1.11.42.50.1-0.3-1.01.0-1.00.9-1.51.4-1.41.5-1.51.3-1.1-1.3-1.41.61.2-1.11.1-1.11.0
Short access total infusions2.02.64.00.90.1-1.71.7-0.90.7-2.02.0-2.02.0-2.01.8-1.6-1.9-2.02.01.4-1.41.4-1.41.3
ShA early post infusion interval0.50.41.2-1.1-0.60.6-0.6-0.60.21.0-0.80.8-0.80.7-0.60.80.60.7-0.5-0.20.6-0.60.6-0.6
ShA late post infusion interval0.50.51.30.20.5-0.80.8-1.10.80.10.4-0.40.4-0.41.0-0.7-0.6-0.51.11.0-0.80.8-0.60.6
ShA early loading1.71.74.9-0.2-1.00.9-0.92.2-2.01.0-0.70.8-0.90.9-1.01.41.10.9-1.8-1.91.6-1.51.5-1.5
ShA late loading0.91.22.2-0.9-1.41.5-1.51.4-1.11.0-0.80.8-1.00.9-0.81.20.70.8-1.5-1.31.0-1.00.9-0.9
Short access day 1 locomotion1.11.43.40.70.1-1.31.3-0.40.4-1.91.5-1.51.5-1.51.2-1.1-1.2-1.51.41.1-0.90.9-0.90.8
Short access day 10 total locomotion1.22.33.01.61.5-1.61.6-1.31.0-1.71.6-1.61.6-1.61.3-1.7-1.2-1.61.51.6-1.61.6-1.51.5
Short access total locomotion3.13.75.51.31.0-2.02.0-1.41.4-2.32.1-2.12.2-2.22.0-2.0-1.9-2.12.32.0-2.01.9-1.81.7
ShA early average infusions4.75.58.8-1.4-2.42.4-2.42.8-2.32.2-1.92.0-2.12.0-2.42.62.32.0-3.0-2.82.6-2.62.4-2.4
ShA late average infusions2.62.74.6-1.1-1.92.1-2.12.1-1.71.4-1.31.3-1.41.4-1.51.81.41.3-2.1-2.01.6-1.51.4-1.4
ShA early timeout2.62.65.6-0.7-1.81.7-1.72.4-2.11.3-1.01.1-1.21.2-1.41.81.41.1-2.3-2.11.7-1.71.6-1.6
ShA late timeout0.30.31.1-0.6-1.01.0-1.00.8-0.40.2-0.20.2-0.30.3-0.30.60.20.2-0.8-0.50.4-0.40.2-0.2
ShA early titration2.73.06.4-0.7-1.41.5-1.52.5-2.01.5-1.21.3-1.31.3-1.61.91.61.3-2.3-2.22.1-2.11.8-1.8
ShA late titration0.70.73.8-0.0-0.80.9-0.91.9-1.50.4-0.30.3-0.40.4-0.60.70.50.4-1.2-1.30.8-0.70.6-0.6
ShA total infusions2.32.85.2-0.8-1.61.8-1.82.3-1.91.5-1.31.3-1.51.5-1.51.81.51.4-2.2-2.11.8-1.81.6-1.6
One hour access (0.3 mA shock)0.40.41.60.7-0.9-0.40.41.3-1.2-0.90.7-0.70.5-0.50.50.1-0.4-0.6-0.1-0.60.6-0.50.5-0.6
Shock compulsivity1.22.25.22.02.3-1.51.5-0.50.1-1.41.7-1.61.6-1.61.7-1.6-1.9-1.61.11.0-1.21.2-1.31.3
Compulsive drug intake1.01.22.3-0.4-0.60.8-0.80.9-1.20.9-0.91.0-1.01.0-1.21.21.01.0-1.2-1.31.5-1.51.5-1.5
One hour access (shock baseline)1.01.52.91.00.0-1.31.3-0.10.4-1.71.6-1.51.5-1.51.6-1.2-1.3-1.51.31.0-1.11.1-1.11.0
Social response proportion4.04.66.42.12.4-2.42.4-1.21.2-2.02.0-2.12.1-2.12.3-2.5-2.3-2.12.52.1-2.22.2-2.12.1
Social responses2.43.17.42.71.6-2.02.01.1-1.1-1.92.3-2.22.1-2.12.1-1.7-2.2-2.11.20.5-1.01.0-1.00.8
Social time1.82.44.71.71.3-2.22.2-0.10.4-1.51.8-1.81.7-1.71.4-1.8-1.5-1.81.61.2-1.41.4-1.51.4
Soleus weight2.57.316.93.83.7-4.14.1-0.0-0.1-2.82.6-2.62.6-2.52.8-3.0-2.9-2.52.41.6-2.12.1-2.12.0
Bone: stiffness1.01.72.91.71.5-1.71.70.0-0.1-1.41.4-1.41.4-1.41.4-1.3-1.4-1.31.00.8-1.21.2-1.11.0
Tibialis anterior weight0.31.01.9-0.4-1.20.9-0.91.0-1.41.3-0.91.0-1.11.1-0.21.10.21.0-1.2-1.30.9-0.91.0-1.1
Time to tail flick, vehicle, before self-admin0.30.30.80.80.2-0.30.30.9-0.8-0.70.8-0.70.6-0.60.5-0.4-0.4-0.7-0.1-0.3-0.30.3-0.30.3
Time to tail flick, vehicle, after self-admin0.20.31.0-0.5-0.41.0-1.00.0-0.30.4-0.40.4-0.40.4-0.70.60.60.4-0.7-0.50.4-0.40.3-0.3
Time to tail flick, test, before self-admin4.04.16.80.61.6-1.81.8-2.42.3-1.91.8-1.81.8-1.91.9-2.1-2.0-1.92.62.4-2.32.3-2.22.2
Time to tail flick, test, after self-admin0.10.10.40.70.2-0.50.50.4-0.5-0.20.2-0.20.2-0.20.3-0.1-0.5-0.10.0-0.20.0-0.00.1-0.2
Delta time to tail flick, vehicle, before/after SA0.50.40.7-0.4-0.30.8-0.80.2-0.50.6-0.60.6-0.60.6-0.70.80.50.7-0.8-0.60.8-0.80.8-0.8
Delta time to tail flick, test, before/after SA0.40.42.40.5-0.40.5-0.51.4-1.50.3-0.20.3-0.20.2-0.00.50.00.4-1.0-1.00.5-0.50.6-0.7
Tibia length1.64.48.82.83.0-2.72.7-0.20.2-2.42.1-2.02.2-2.22.1-2.4-1.9-2.02.01.4-1.81.8-1.81.7
Ambulatory time before self-admin1.42.13.70.71.3-1.01.0-1.51.5-1.41.2-1.31.2-1.21.6-1.7-1.3-1.31.61.6-1.71.7-1.81.9
Ambulatory time after self-admin2.12.43.90.91.7-1.81.8-1.71.8-1.51.2-1.31.3-1.31.4-1.8-1.4-1.32.01.9-1.61.6-1.61.7
Bone: tissue strength0.40.40.6-0.6-0.70.5-0.50.3-0.20.8-0.80.8-0.70.7-0.70.70.70.7-0.6-0.60.6-0.60.6-0.6
Total heroin consumption0.30.31.61.30.1-0.70.71.2-1.1-0.40.5-0.50.3-0.30.4-0.2-0.2-0.4-0.0-0.50.4-0.40.4-0.4
Total infusions0.20.32.60.8-0.10.0-0.01.6-1.2-0.00.3-0.20.1-0.10.10.2-0.1-0.1-0.7-0.70.4-0.40.3-0.3
Bone: trabecular number0.81.34.30.6-0.20.3-0.32.0-2.11.1-0.70.8-1.01.0-0.61.00.60.8-1.4-1.81.2-1.21.4-1.4
Bone: trabecular spacing0.10.10.2-0.5-0.50.3-0.3-0.30.30.0-0.30.3-0.10.1-0.50.30.50.3-0.30.10.3-0.30.1-0.1
Bone: trabecular thickness1.21.56.72.61.7-1.51.52.2-2.3-0.91.1-1.00.8-0.80.9-0.6-0.8-0.8-0.1-0.90.3-0.30.4-0.5
Bone: trabecular tissue density1.31.92.60.81.2-1.11.1-1.41.0-1.61.4-1.41.5-1.61.3-1.5-1.4-1.41.41.5-1.51.5-1.61.6
Water consumed over 24 hours0.91.22.31.11.3-1.51.5-0.90.8-1.21.0-1.01.0-1.00.9-1.2-0.9-1.01.11.2-1.01.0-1.01.1
Number of responses in last shaping day0.30.41.00.20.1-0.50.5-0.60.3-0.50.5-0.50.5-0.51.0-0.7-0.9-0.50.80.5-0.70.7-0.60.6