LOC120100064

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	gene expression	LOC120100064	0.14	0.07	2.9e-07	0.12	0.1	0.1	0.11	5.4e-07	7.6e-06	4.7e-06	2.3e-06
2	NAcc	gene expression	LOC120100064	0.14	0.06	0.0e+00	0.17	0.17	0.15	0.17	9.8e-20	5.4e-19	2.3e-17	2.3e-19
3	IL	gene expression	LOC120100064	0.26	0.16	2.4e-03	0.02	0.02	0.02	-0	1.2e-01	1.3e-01	1.1e-01	3.5e-01
4	Brain	gene expression	LOC120100064	0.14	0.06	8.9e-16	0.19	0.18	0.18	0.2	3.2e-17	7.0e-17	8.1e-17	1.9e-18
5	OFC	gene expression	LOC120100064	0.55	0.16	1.3e-09	0.19	0.26	0.3	0.29	2.9e-05	5.4e-07	6.4e-08	1.4e-07
6	PL	gene expression	LOC120100064	0.14	0.06	0.0e+00	0.16	0.16	0.16	0.18	1.1e-17	1.8e-17	2.4e-17	5.5e-19

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.6	1.0	4.5	0.4	-0.0	-2.1	0.5	-0.6	0.8
Area under the delay curve	0.1	0.1	0.5	0.4	0.2	-0.7	-0.1	0.0	0.0
BMI with tail	2.7	8.7	18.2	4.3	3.4	-1.9	-2.8	2.8	-1.7
BMI without tail	1.0	2.1	5.4	2.3	1.6	-1.2	-1.2	1.2	-0.5
Body weight	2.9	12.1	29.6	5.4	3.9	-2.4	-3.0	3.1	-1.9
Weight adjusted by age	3.8	4.3	7.3	2.2	2.7	-0.2	-2.5	1.8	-2.0
Bone surface	0.2	0.3	1.3	0.4	0.0	-1.1	0.2	0.0	0.4
Bone volume	0.5	0.9	3.2	1.2	0.7	-1.8	-0.1	0.2	0.2
Breakpoint value in progressive ratio session	1.1	1.2	2.2	-0.1	-1.1	-0.7	1.4	-1.0	1.5
Number of licking bursts	0.5	0.6	1.2	0.2	-0.4	-1.1	0.7	-0.9	0.8
Context. condit. distance diff. score	0.3	0.4	0.8	-0.1	-0.9	0.7	0.8	-0.5	0.5
Locomotion velocity, session 1	0.3	0.3	1.5	-1.2	-0.0	0.3	-0.2	0.2	-0.4
Locomotion distance, session 1	1.8	2.4	3.5	0.3	1.6	1.7	-1.8	1.5	-1.9
Locomotion velocity, session 2	2.2	2.6	3.9	1.1	1.2	2.0	-1.6	1.7	-1.8
Locomotion distance, session 2	2.9	4.0	5.2	1.9	1.9	1.4	-2.2	2.3	-2.2
Locomotion velocity, session 3	1.5	1.8	2.6	0.9	1.3	1.4	-1.6	1.1	-1.6
Locomotion distance, session 3	2.3	2.5	3.5	1.3	1.4	1.8	-1.7	1.3	-1.9
Stereotopy head waving bouts, day 3	0.0	0.0	0.1	-0.1	0.3	-0.2	-0.1	0.1	-0.1
Stereotopy head waving duration, day 3	0.5	0.6	1.6	-1.3	-0.4	-0.8	0.7	-0.7	0.7
Locomotion velocity, session 7	0.0	0.0	0.1	0.1	-0.1	-0.4	-0.2	0.3	-0.1
Locomotion distance, session 7	0.1	0.1	0.3	0.1	-0.4	0.5	-0.0	0.6	-0.1
Stereotopy head waving bouts, day 7	0.1	0.1	0.3	0.2	-0.2	-0.6	0.2	-0.1	0.3
Stereotopy head waving duration, day 7	0.2	0.2	1.1	0.3	0.3	-1.1	-0.1	0.2	0.0
Locomotion velocity, session 8	0.9	1.0	2.0	-1.4	-1.4	0.8	1.0	-0.5	0.6
Locomotion distance, session 8	0.4	0.7	3.1	0.3	-0.1	1.7	-0.3	0.5	-0.7
Degree of sensitization distance	3.2	3.2	4.7	-1.4	-2.2	-1.2	2.2	-1.2	2.2
Degree of sensitization stereotypy	0.1	0.2	0.5	0.0	-0.4	-0.7	0.3	-0.2	0.4
Conditioned locomotion	0.1	0.1	0.1	-0.1	0.1	0.3	-0.3	0.1	-0.3
Cocaine response after cond. corrected	1.2	1.3	5.5	-0.4	0.3	2.3	-0.5	0.9	-1.0
Cocaine response after cond. not corrected	0.7	0.8	3.5	-0.9	-0.2	1.9	0.1	0.3	-0.3
Cocaine response before conditioning	1.8	2.1	2.9	-1.0	-1.4	-1.5	1.5	-1.6	1.7
Saline control response	0.4	0.5	0.7	0.3	0.8	0.7	-0.7	0.9	-0.8
Bone: connectivity density	0.4	0.7	0.9	-0.7	-0.8	-1.0	0.8	-0.7	0.9
Bone: cortical apparent density	3.1	4.1	6.6	1.5	1.7	2.6	-2.0	1.7	-2.3
Bone: cortical area	2.8	4.2	8.5	2.9	2.5	-2.1	-1.6	1.6	-1.0
Bone: cortical porosity	0.3	0.3	0.5	-0.3	-0.4	-0.7	0.6	-0.7	0.6
Bone: cortical porosity	0.7	0.7	1.1	-0.2	-0.7	-1.0	1.0	-0.9	1.0
Bone: cortical thickness	2.1	3.4	6.8	2.6	2.3	-1.0	-1.7	1.6	-1.3
Bone: cortical thickness	1.7	2.0	4.3	2.1	1.4	0.1	-1.4	1.4	-1.2
Bone: cortical tissue density	2.8	3.7	6.9	1.3	1.6	2.6	-1.9	1.6	-2.2
Condit. Reinf. active minus inactive responses	0.2	0.2	0.4	0.2	0.7	0.6	-0.4	0.2	-0.5
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.1	-0.4	0.3	0.2	0.1	-0.4	0.1
Condit. Reinf. active responses	0.4	0.6	1.4	0.5	1.2	-0.0	-0.9	0.5	-0.8
Condit. Reinf. inactive responses	0.5	0.6	1.0	0.3	1.0	-0.7	-1.0	0.7	-0.7
Incentive salience index mean	0.4	0.5	1.0	0.0	0.8	1.0	-0.7	0.5	-0.8
Condit. Reinf. lever presses	0.3	0.4	0.7	-0.2	0.7	0.7	-0.8	0.5	-0.8
Condit. Reinf. active minus inactive responses	1.0	1.3	5.4	-0.9	0.5	-2.3	0.2	-0.9	0.6
Condit. Reinf. active-inactive response ratio	0.7	0.8	2.0	-1.2	-0.1	-1.4	0.2	-0.9	0.5
Condit. Reinf. active responses	1.2	1.7	8.3	-0.3	0.9	-2.9	0.0	-0.7	0.6
Condit. Reinf. inactive responses	0.5	0.7	3.1	0.4	0.6	-1.8	0.2	-0.1	0.4
Condit. Reinf. lever presses	0.4	0.6	2.2	-0.3	-0.0	-1.5	0.5	-0.6	0.6
Condit. Reinf. lever reinforcers received	0.9	1.3	6.2	-0.4	0.8	-2.5	0.1	-0.7	0.6
Conditioned reinforcement - actives	1.8	1.8	2.7	0.9	1.0	1.7	-1.3	1.3	-1.6
Conditioned reinforcement - inactives	0.3	0.3	0.5	0.7	0.7	-0.1	-0.7	0.4	-0.5
Conditioned locomotion	1.3	1.6	3.3	0.8	0.9	1.8	-1.1	1.1	-1.6
Patch foraging indifference point 0 sec	0.8	1.3	3.4	1.3	1.1	-1.8	-0.8	0.9	-0.4
Patch foraging indifference point AUC	0.3	0.4	1.5	-0.7	-0.1	-1.2	0.3	-0.2	0.4
Delay disc. indifference point, 0s delay	0.4	0.4	1.6	1.3	0.4	0.1	-0.3	0.7	-0.3
Delay disc. indifference point, 16s delay	0.2	0.2	0.2	-0.3	-0.5	-0.5	0.5	-0.3	0.4
Delay disc. indifference point, 2s delay	0.1	0.1	0.2	0.5	-0.4	0.2	0.3	0.0	0.2
Delay disc. indifference point, 24s delay	1.1	1.0	2.8	-0.1	-0.7	-1.7	0.9	-0.8	1.1
Delay disc. indifference point, 4s delay	0.3	0.3	0.6	-0.4	-0.8	-0.2	0.7	-0.4	0.6
Delay disc. indifference point, 8s delay	1.2	1.2	2.4	1.0	1.6	-0.9	-1.2	1.0	-0.9
Indifference point function ln k	0.1	0.1	0.2	0.3	0.3	0.4	-0.4	0.3	-0.5
Indifference point function log k	0.1	0.1	0.2	0.3	0.3	0.4	-0.4	0.3	-0.5
Patch foraging total patch changes 0 sec	0.8	1.2	4.4	1.1	0.9	-2.1	-0.6	0.7	-0.2
Patch foraging total patch changes 12 sec	0.6	0.8	3.8	-0.2	-0.3	-1.9	0.5	-0.3	0.8
Patch foraging total patch changes 18 sec	0.7	0.9	4.9	0.0	0.4	-2.2	-0.0	-0.1	0.4
Patch foraging total patch changes 24 sec	0.9	1.0	5.3	-0.2	-0.0	-2.3	0.4	-0.3	0.8
Patch foraging total patch changes 6 sec	1.0	1.5	4.7	1.2	1.2	-2.2	-0.7	0.7	-0.2
Patch foraging time to switch 0 sec	0.1	0.2	0.6	-0.0	-0.4	0.8	0.4	-0.1	0.3
Patch foraging water rate 0 sec	0.1	0.2	0.5	0.2	0.7	-0.7	-0.4	0.4	-0.3
Patch foraging water rate 12 sec	0.6	0.9	4.1	-0.6	-0.1	-2.0	0.5	-0.3	0.9
Patch foraging water rate 18 sec	0.6	0.8	1.3	0.9	1.1	0.2	-1.0	1.0	-0.9
Patch foraging water rate 24 sec	0.9	1.3	2.3	1.5	1.2	0.3	-1.0	1.3	-1.1
Patch foraging water rate 6 sec	0.5	0.7	1.3	0.8	0.9	0.6	-0.8	1.2	-0.8
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.7	0.4	-0.3	0.9	-0.1	0.5	-0.3
Distance traveled before self-admin	0.4	0.4	0.7	0.2	0.2	0.9	-0.6	0.6	-0.8
Distance traveled after self-admin	2.1	2.3	3.1	1.8	1.1	1.7	-1.3	1.5	-1.7
Extensor digitorum longus weight	0.1	0.5	2.6	0.3	-0.1	-1.6	0.3	-0.0	0.5
Bone: elastic displacement	0.2	0.3	0.5	-0.4	-0.6	-0.4	0.4	-0.7	0.5
Bone: elastic work	1.3	1.7	2.6	1.6	1.4	0.6	-1.4	1.2	-1.4
Bone: endosteal estimation	0.3	0.6	1.4	1.2	0.8	-1.0	-0.4	0.7	-0.2
Bone: endosteal perimeter	1.8	3.7	6.4	2.5	2.5	-1.2	-1.8	1.9	-1.3
Epididymis fat weight	3.9	9.0	23.2	4.8	3.3	-2.8	-2.4	2.3	-1.3
Delta time in closed arm before/after self-admin	0.3	0.3	0.6	0.6	0.3	0.8	-0.5	0.4	-0.6
Delta time in open arm before/after self-admin	0.2	0.2	0.7	-0.2	-0.3	-0.8	0.3	-0.6	0.4
Diff in mean of infusions in LGA sessions	3.9	4.3	6.8	-1.9	-2.6	-0.5	2.5	-2.1	2.2
Delay discount exponential model param	0.1	0.1	0.5	-0.4	-0.2	0.7	0.1	-0.0	-0.0
Extinction: sum of active levers before priming	0.9	0.9	1.3	-0.6	-1.1	-0.2	1.1	-1.1	1.1
Active lever presses in extinction session 6	0.3	0.3	0.9	0.9	0.4	-0.0	-0.0	-0.7	0.1
Bone: final force	1.7	2.7	4.7	2.2	2.0	-0.4	-1.5	1.8	-1.3
Bone: final moment	1.5	2.5	4.8	2.2	1.9	-0.5	-1.4	1.7	-1.2
Food consumed during 24 hour testing period	0.1	0.1	0.5	0.3	-0.1	0.3	0.2	-0.7	0.2
Glucose	1.9	2.9	6.6	2.6	1.9	-1.3	-1.7	1.1	-1.1
Heart weight	1.5	2.1	4.0	2.0	1.8	-0.5	-1.5	1.1	-1.2
Delay discount hyperbolic model param	0.1	0.1	0.3	-0.4	-0.0	0.6	-0.0	-0.0	-0.1
Intermittent access intake day 1-15 change	0.7	0.7	1.3	1.1	1.2	-0.8	-0.7	0.3	-0.2
Intermittent access intake escalation	2.7	2.6	4.7	2.2	2.1	0.2	-1.8	1.3	-1.4
Intermittent access intake escalation 2	2.1	2.1	3.3	1.8	1.7	0.7	-1.6	1.3	-1.4
Intermitt. access day 1 inactive lever presses	0.4	0.4	2.1	0.4	-0.0	-1.5	-0.0	-0.2	0.5
Intermitt. access day 15 inactive lever presses	0.1	0.1	0.3	0.5	0.5	0.0	-0.4	-0.1	-0.1
Intermitt. access escalation Index	0.1	0.1	0.4	0.7	-0.1	0.1	-0.3	0.0	-0.2
Intermittent access day 1 total infusions	0.3	0.3	0.6	0.8	0.3	0.5	-0.4	0.5	-0.7
Intermittent access day 15 total infusions	1.2	1.4	3.3	1.8	1.2	0.4	-1.1	1.0	-1.1
Intermittent access terminal intake (last 3 days)	0.7	0.8	1.8	1.4	0.9	0.4	-0.7	0.8	-0.9
Intermittent access total infusions	1.3	1.4	2.0	1.4	1.3	0.5	-1.2	1.3	-1.3
Intermittent access day 1 locomotion	1.0	1.0	1.9	1.0	0.6	1.4	-0.8	1.0	-1.2
Intermittent access day 15 total locomotion	0.9	1.0	2.0	1.2	1.4	-0.6	-1.1	0.8	-0.7
Intermittent access total locomotion	2.0	2.3	2.9	1.4	1.5	1.3	-1.5	1.7	-1.7
Intermittent access standard deviation	0.3	0.3	1.4	0.2	-0.1	-1.2	0.1	-0.2	0.4
Left kidney weight	5.1	14.4	24.6	5.0	3.6	2.6	-3.6	3.9	-3.7
Right kidney weight	6.1	17.2	28.1	5.3	4.3	1.5	-4.2	4.6	-4.0
Cocaine induced anxiety	1.3	1.5	3.2	-1.0	-1.5	1.8	1.2	-0.7	0.6
Post-drug Anxiety	0.3	0.3	1.5	0.0	-0.5	1.2	0.4	-0.2	0.2
Baseline Anxiety	1.5	1.6	2.9	1.5	1.5	-1.7	-1.2	0.5	-0.5
Tail length	0.1	0.3	0.6	0.7	-0.0	-0.8	0.3	-0.3	0.4
Length with tail	0.8	3.0	8.6	2.9	1.9	-0.9	-1.4	1.4	-1.0
Length without tail	2.1	4.6	9.2	3.0	2.6	-0.8	-2.1	2.0	-1.6
Times rat made contact with spout	0.7	0.8	1.6	1.3	0.9	0.6	-0.9	0.6	-0.9
Lifetime Intake	1.6	1.9	2.5	1.6	1.4	0.6	-1.4	1.4	-1.6
Liver weight, left	0.9	1.5	3.1	1.8	1.3	-1.7	-0.8	0.8	-0.3
Liver weight, right	2.5	4.1	10.1	3.2	2.3	-1.2	-1.7	2.0	-1.2
Locomotor activity	1.2	1.9	4.5	2.1	1.4	0.1	-1.3	1.4	-1.2
Locomotor testing distance	2.6	4.4	6.8	2.6	2.2	0.9	-2.2	2.2	-2.1
Locomotor testing rearing	0.9	1.4	3.3	1.8	1.2	0.3	-1.1	1.3	-0.9
Locomotion in novel chamber	1.1	1.4	2.4	1.1	0.8	1.6	-1.1	1.0	-1.3
Locomotion in novel chamber post-restriction	1.1	1.4	3.7	-0.0	0.7	1.9	-1.0	1.1	-1.3
Fecal boli incidents, locomotor time 1	0.4	0.4	1.6	-0.2	0.6	-1.3	-0.4	0.3	0.0
Change in fecal boli incidents, locomotor task	1.1	1.1	1.8	-0.6	-1.4	0.5	1.2	-1.3	1.0
Time >=10cm from walls, locomotor time 1	1.0	1.0	1.9	-1.4	-1.1	0.2	1.0	-1.1	0.9
Bouts of movement, locomotor time 1	0.3	0.3	1.6	0.2	-0.2	-1.2	0.3	-0.2	0.4
Total resting periods, locomotor time 1	0.1	0.2	0.8	0.4	-0.1	-0.9	0.1	0.1	0.2
Rest time, locomotor task time 1	1.4	1.5	2.8	1.1	1.0	1.0	-1.2	1.7	-1.3
Distance moved, locomotor task time 1	0.5	0.5	1.7	-0.3	-0.5	-0.6	0.6	-1.3	0.6
Vertical activity count, locomotor time 1	0.4	0.4	1.2	-0.3	-0.5	0.3	0.6	-1.1	0.5
Time >=10cm from walls, locomotor time 2	0.9	0.9	1.5	-0.2	-0.8	-0.9	1.1	-1.1	1.2
Bouts of movement, locomotor time 2	0.8	0.9	2.5	-0.7	-1.6	0.6	1.2	-0.4	0.6
Total resting periods, locomotor time 2	0.4	0.5	1.5	-0.4	-1.2	0.6	0.8	-0.1	0.3
Rest time, locomotor task time 2	0.6	0.7	1.1	0.6	0.7	0.5	-1.0	1.0	-0.9
Distance moved, locomotor task time 2	0.2	0.2	0.6	-0.1	-0.1	-0.8	0.4	-0.6	0.4
Vertical activity count, locomotor time 2	0.2	0.2	0.6	0.1	-0.1	-0.8	0.3	-0.4	0.6
Light reinforcement 1	0.5	0.8	1.7	-0.9	-1.3	0.9	0.8	-0.9	0.5
Light reinforcement 2	0.6	0.8	1.9	-0.6	-1.3	1.4	0.6	-0.5	0.2
Bone: marrow area	0.3	0.6	1.5	1.2	0.8	-1.0	-0.4	0.7	-0.2
Bone: maximum diameter	1.9	3.5	7.0	2.5	2.1	-2.7	-1.2	1.2	-0.6
Bone: maximum force	1.6	2.7	4.8	2.2	2.0	-0.4	-1.5	1.8	-1.3
Bone: maximum moment	1.4	2.4	4.7	2.2	1.9	-0.5	-1.4	1.6	-1.1
Mean time between licks in bursts	0.3	0.5	0.7	-0.3	-0.5	-0.8	0.8	-0.7	0.8
Mean num. licks in bursts	2.0	2.4	3.2	1.1	1.4	1.6	-1.7	1.7	-1.8
Cd content in liver	1.7	1.9	4.7	-2.2	-1.5	0.2	1.3	-1.2	1.0
Co content in liver	0.2	0.2	0.5	-0.3	0.1	0.7	-0.5	0.6	-0.6
Cu content in liver	0.2	0.2	0.4	0.3	0.6	0.4	-0.5	0.5	-0.5
Fe content in liver	0.1	0.1	0.2	-0.4	-0.0	-0.2	0.1	-0.4	0.2
K content in liver	0.5	0.5	1.0	-0.9	-1.0	-0.2	0.7	-0.3	0.5
Mg content in liver	0.7	0.7	0.9	-0.8	-0.9	-0.8	0.9	-0.6	0.9
Mn content in liver	0.5	0.5	1.3	-0.4	-1.1	0.5	0.9	-0.5	0.7
Na content in liver	1.4	1.5	1.8	-1.3	-1.3	-0.9	1.3	-0.9	1.3
Rb content in liver	2.2	2.7	4.2	-1.6	-1.9	-0.5	2.0	-1.5	1.8
Se content in liver	0.3	0.4	0.8	-0.9	-0.5	-0.5	0.5	-0.8	0.6
Sr content in liver	0.8	0.8	3.2	-0.7	-0.8	1.8	0.2	0.3	-0.2
Zn content in liver	0.5	0.5	1.8	-0.7	-0.8	1.3	0.4	0.1	0.1
Bone: minimum diameter	0.7	1.3	3.0	1.7	1.1	-1.7	-0.5	0.7	-0.1
Time in familiar zone, hab. session 1	0.2	0.2	0.2	-0.0	0.4	0.4	-0.4	0.5	-0.4
Time in novel zone, hab. session 1	0.4	0.4	1.1	0.1	-0.4	-1.0	0.4	-0.6	0.7
Total zone transitions, hab. session 1	1.9	2.6	4.2	2.1	1.6	0.8	-1.7	1.7	-1.6
Total locomotion distance, hab. session 1	0.1	0.1	0.2	0.5	-0.1	0.4	-0.2	-0.2	-0.2
Locomotion velocity, hab. session 1	0.1	0.1	0.3	0.4	-0.1	0.6	-0.2	-0.3	-0.2
Time in familiar zone, hab. session 2	0.9	0.9	2.9	-0.2	-0.0	-1.7	0.7	-1.0	1.0
Time in novel zone, hab. session 2	1.4	1.4	2.2	0.6	0.7	1.5	-1.3	1.4	-1.5
Total zone transitions, hab. session 2	2.0	2.5	4.1	2.0	1.7	0.7	-1.6	1.7	-1.5
Total locomotion distance, hab. session 2	0.7	1.0	2.1	1.5	1.0	0.8	-0.9	0.6	-0.9
Locomotion velocity, hab. session 2	0.6	0.8	1.7	1.3	0.8	0.9	-0.7	0.6	-0.7
Novel to familiar place preference ratio	0.5	0.5	0.8	-0.4	-0.6	-0.9	0.6	-0.8	0.6
Novelty place preference	0.4	0.4	0.9	-0.3	-0.5	-1.0	0.5	-0.7	0.6
Time in novel zone, NPP test	0.6	0.7	2.0	-0.3	-0.5	-1.4	0.6	-0.9	0.7
Total zone transitions, NPP test	0.8	1.2	2.3	1.5	0.9	0.7	-0.9	1.2	-1.0
Total locomotion distance, NPP test	0.2	0.3	1.2	1.1	0.4	0.6	-0.3	0.2	-0.3
Locomotion velocity, NPP test	0.4	0.5	1.5	1.0	0.4	1.2	-0.4	0.4	-0.5
Intraocular pressure	1.0	1.4	3.2	1.1	1.5	-1.8	-1.0	0.4	-0.5
Delta distance traveled before/after self-admin	1.2	1.3	3.7	1.9	0.9	0.9	-0.9	0.9	-1.0
Delta ambulatory time before/after self-admin	0.4	0.4	1.8	1.4	0.4	0.1	-0.3	0.3	-0.3
Parametrial fat weight	1.5	3.0	11.1	2.0	1.5	-3.3	-0.8	0.4	0.2
Pavlov. Cond. lever latency	0.5	0.7	1.3	-0.7	-0.5	-1.1	0.6	-0.9	0.8
Pavlov. Cond. magazine entry latency	0.4	0.5	2.0	1.4	0.6	0.5	-0.5	0.4	-0.4
Pavlov. Cond. change in total contacts	0.3	0.3	0.8	0.9	0.2	0.5	-0.2	0.7	-0.3
Pavlov. Cond. index score	0.5	0.6	1.9	1.4	0.7	0.5	-0.6	0.7	-0.5
Pavlov. Cond. latency score	0.5	0.6	1.5	1.2	0.6	0.5	-0.6	0.8	-0.6
Pavlov. Cond. lever contacts	0.1	0.2	0.2	0.4	0.4	0.4	-0.4	0.5	-0.4
Pavlov. Cond. magazine entry number	1.0	1.3	3.4	-1.8	-1.3	-0.3	1.0	-0.9	0.8
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.4	0.1	0.6	-0.0	-0.6	0.3	-0.7
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	1.3	1.2	0.5	0.3	-0.4	0.5	-0.3
Pavlov. Cond. response bias	0.8	0.9	2.3	1.5	0.9	0.7	-0.9	0.8	-0.8
Pavlov. Cond. lever latency	0.5	0.7	2.0	0.6	0.3	1.4	-0.7	0.6	-0.8
Pavlov. Cond. magazine entry latency	0.3	0.3	0.9	0.9	0.0	-1.0	0.2	-0.2	0.3
Pavlov. Cond. change in total contacts	0.4	0.5	2.5	-0.1	0.3	-1.6	0.3	-0.4	0.5
Pavlov. Cond. index score	0.3	0.4	1.6	0.5	0.4	-1.3	0.1	-0.2	0.2
Pavlov. Cond. latency score	0.3	0.4	1.6	0.5	0.3	-1.3	0.2	-0.3	0.3
Pavlov. Cond. lever contacts	0.1	0.2	0.8	0.3	0.1	-0.9	0.3	-0.1	0.3
Pavlov. Cond. magazine entry number	0.2	0.3	0.8	-0.8	-0.2	0.9	-0.1	0.1	-0.2
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.2	0.1	-0.2	-0.4	0.2	-0.4	0.3
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.3	1.1	0.7	0.6	-1.1	-0.1	0.0	0.0
Pavlov. Cond. response bias	0.3	0.3	1.4	0.5	0.2	-1.2	0.3	-0.2	0.4
Time in closed arm before self-admin	0.0	0.0	0.1	0.0	0.0	-0.1	0.1	0.3	0.2
Time in closed arm after self-admin	0.1	0.1	0.5	0.2	-0.3	0.7	0.2	0.4	0.1
Time in open arm before self-admin	1.0	1.1	1.5	-1.0	-1.2	0.3	1.1	-1.2	1.1
Time in open arm after self-admin	0.7	0.8	1.4	-1.0	-0.8	-0.6	0.9	-1.2	0.8
Bone: periosteal estimation	1.5	3.1	6.6	2.6	2.1	-1.7	-1.3	1.6	-0.8
Bone: periosteal perimeter	3.6	6.0	9.9	3.1	3.1	-1.9	-2.3	2.3	-1.6
Bone: post-yield work	0.3	0.4	0.8	-0.1	-0.7	-0.5	0.9	-0.5	0.8
Progressive ratio test 1 active lever presses	2.3	2.4	3.6	1.9	1.8	1.2	-1.5	1.2	-1.6
Progressive ratio test 1 breakpoint	1.1	1.1	1.7	1.3	1.2	0.8	-1.0	0.8	-1.2
Progressive ratio test 1 inactive lever presses	0.2	0.3	0.8	0.9	0.5	0.2	-0.6	-0.0	-0.3
Progressive ratio test 2 active lever presses	2.9	3.1	5.0	2.2	2.0	0.7	-1.8	1.7	-1.8
Progressive ratio test 2 breakpoint	2.3	2.6	4.3	2.1	1.8	0.6	-1.6	1.5	-1.5
Progressive ratio test 2 inactive lever presses	0.3	0.3	0.7	0.8	0.5	-0.7	-0.5	0.2	-0.4
Incentive Sensitization - Responses	0.8	0.8	1.5	1.2	1.0	-0.2	-0.9	1.0	-0.7
Incentive Sensitization - Breakpoint	0.7	0.7	1.3	1.2	1.0	-0.4	-0.9	0.9	-0.6
Sum of active levers in priming session hrs 5-6	1.5	1.4	2.5	-1.3	-1.3	-0.1	1.2	-1.6	1.1
Progressive ratio	0.2	0.3	0.5	-0.6	-0.4	0.3	0.4	-0.7	0.4
Food seeking constrained by brief footshock	1.6	1.9	2.8	-1.1	-1.3	-0.9	1.5	-1.6	1.7
Seeking ratio, punishment vs. effort	0.1	0.1	0.3	0.0	-0.4	-0.5	0.4	-0.0	0.3
Retroperitoneal fat weight	3.6	11.8	28.3	5.3	3.8	-2.9	-2.9	2.8	-1.8
Reaction time number correct	0.2	0.2	1.0	0.5	0.2	-1.0	0.1	0.2	0.3
Reaction time mean minus median	0.9	1.1	2.5	1.1	1.6	0.4	-1.1	0.9	-1.0
Reaction time mean minus median AUC	1.7	2.3	3.6	1.9	1.7	1.1	-1.4	1.5	-1.4
Reaction time num false alarms	0.0	0.0	0.1	0.2	-0.2	0.2	-0.1	0.1	-0.0
Reaction time num false alarms AUC	0.2	0.2	0.6	0.7	0.1	0.6	-0.4	0.4	-0.4
Reaction time trials correct on left	0.2	0.2	1.0	0.5	0.2	-1.0	0.1	0.2	0.3
Reaction time trials on left	0.2	0.2	1.0	0.5	0.2	-1.0	0.1	0.2	0.3
Reaction time mean	0.7	0.9	1.9	0.9	1.4	0.3	-1.0	0.9	-0.9
Reaction time mean AUC	0.3	0.4	0.9	0.6	0.9	0.3	-0.6	0.6	-0.6
Median of all reaction times	0.6	0.9	1.5	0.9	1.2	0.4	-1.0	0.9	-1.0
Reaction time omissions	0.1	0.1	0.3	0.5	0.2	-0.3	-0.2	0.2	-0.1
Reaction time false alarm rate	0.1	0.1	0.5	0.1	-0.2	0.7	-0.2	-0.0	-0.2
Reaction time premature initiation rate	1.8	2.4	3.4	1.6	1.4	1.2	-1.7	1.5	-1.9
Reaction time premature initiations	2.0	2.8	4.0	2.0	1.7	0.8	-1.8	1.7	-1.8
Std. dev. reaction times	1.6	2.2	4.3	1.7	2.1	0.1	-1.5	1.3	-1.3
Reaction time trials completed	0.2	0.2	1.0	0.5	0.2	-1.0	0.1	0.2	0.3
Reaction time trials AUC	0.2	0.3	1.1	0.5	0.3	-1.0	0.0	0.3	0.2
Run reversals in cocaine runway, females	1.0	1.0	1.5	1.1	1.2	0.4	-1.2	0.9	-1.0
Run reversals in cocaine runway, males	1.9	1.8	3.7	-1.2	-1.9	-0.1	1.6	-1.4	1.3
Latency to leave start box in cocaine runway	0.2	0.2	0.4	-0.4	-0.4	0.6	0.1	-0.7	0.2
Latency to leave start box in cocaine runway, F	0.2	0.3	0.6	-0.6	-0.4	0.6	0.3	-0.8	0.2
Latency to leave start box in cocaine runway, M	0.2	0.2	0.6	0.7	0.2	0.3	-0.5	0.5	-0.4
Std. dev. time between licks in bursts	0.3	0.4	0.6	-0.7	-0.8	-0.1	0.8	-0.3	0.7
Total sessions with >9 infusions	7.2	7.9	9.8	3.0	3.1	1.2	-3.1	3.0	-3.0
Short access day 1 total inactive lever presses	0.2	0.2	0.9	0.9	0.4	0.0	-0.4	-0.4	-0.1
Short access day 10 total inactive lever presses	0.2	0.2	0.6	0.3	0.4	-0.8	-0.5	0.2	-0.1
Short access day 1 total infusions	1.9	2.0	3.1	1.8	1.3	1.1	-1.4	1.4	-1.5
Short access day 10 total infusions	1.2	1.3	1.8	1.1	1.1	1.1	-1.1	1.1	-1.3
Short access total infusions	1.9	2.1	3.0	1.6	1.4	1.1	-1.4	1.5	-1.7
Short access day 1 locomotion	1.3	1.4	2.0	1.3	1.4	0.8	-1.2	1.1	-1.3
Short access day 10 total locomotion	0.9	1.0	1.6	1.3	1.0	0.7	-0.8	1.1	-0.9
Short access total locomotion	4.0	4.2	5.4	2.1	1.8	1.9	-1.8	2.3	-2.2
One hour access (0.3 mA shock)	0.3	0.4	1.2	0.8	0.4	-1.1	-0.2	-0.0	0.0
Compulsive drug intake	0.9	1.0	1.5	-1.2	-1.0	-0.7	0.8	-1.1	0.9
One hour access (shock baseline)	1.7	2.0	4.0	2.0	1.5	0.1	-1.4	1.5	-1.3
Social response proportion	4.5	4.8	6.1	2.5	2.3	1.3	-2.3	2.3	-2.3
Social responses	2.0	2.6	4.6	2.1	2.1	-0.8	-1.6	1.3	-1.3
Social time	2.0	2.6	5.1	2.2	1.8	0.4	-1.5	1.6	-1.4
Soleus weight	2.7	8.1	17.9	4.2	2.8	-0.1	-2.6	3.2	-2.3
Bone: stiffness	1.4	2.2	3.5	1.9	1.8	-0.1	-1.4	1.8	-1.2
Tibialis anterior weight	0.1	0.4	1.2	-0.9	-0.4	-1.1	0.4	-0.1	0.4
Time to tail flick, vehicle, before self-admin	0.5	0.5	1.9	0.4	0.8	-1.4	-0.4	0.0	-0.0
Time to tail flick, vehicle, after self-admin	0.4	0.4	0.9	-0.0	0.9	0.2	-0.9	0.5	-0.7
Time to tail flick, test, before self-admin	5.5	5.4	6.2	2.2	2.3	2.1	-2.4	2.4	-2.5
Time to tail flick, test, after self-admin	0.7	0.7	1.3	1.1	1.1	-0.7	-0.8	0.7	-0.4
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.1	-0.1	0.2	0.4	-0.3	0.0	-0.3
Delta time to tail flick, test, before/after SA	0.8	0.7	3.6	-0.2	0.0	-1.9	0.3	-0.5	0.7
Tibia length	1.4	3.9	6.8	2.6	2.3	0.3	-2.1	1.9	-1.7
Ambulatory time before self-admin	0.6	0.6	0.9	0.8	0.6	0.6	-0.9	0.8	-0.9
Ambulatory time after self-admin	1.8	2.0	3.4	1.9	1.0	1.5	-1.2	1.3	-1.4
Bone: tissue strength	0.4	0.4	0.5	-0.7	-0.6	-0.4	0.7	-0.6	0.6
Total heroin consumption	0.3	0.4	1.2	0.2	-0.2	-1.1	0.5	-0.6	0.8
Bone: trabecular number	0.8	1.2	3.3	-0.5	-0.7	-1.8	0.9	-1.0	1.2
Bone: trabecular spacing	0.1	0.1	0.2	-0.2	-0.4	-0.1	0.5	-0.3	0.4
Bone: trabecular thickness	1.1	1.4	4.1	1.6	1.0	-2.0	-0.5	0.3	-0.0
Bone: trabecular tissue density	1.5	2.1	3.1	1.2	1.7	0.8	-1.5	1.7	-1.5
Water consumed over 24 hours	0.9	1.1	2.6	1.6	0.9	1.0	-0.9	0.7	-1.0
Number of responses in last shaping day	0.5	0.5	1.1	0.5	0.5	0.4	-0.8	0.7	-1.0