Cad

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	Cad	0.06	0.04	4.1e-08	0.06	0.06	0.06	0.06	2.2e-07	2.1e-07	3.8e-07	3.7e-07
2	IL	gene expression	Cad	0.83	0.19	1.3e-05	0.18	0.14	0.17	0.18	4.7e-05	2.4e-04	5.4e-05	4.2e-05
3	Brain	gene expression	Cad	0.09	0.07	2.1e-07	0.07	0.07	0.07	0.06	6.3e-07	6.1e-07	5.0e-07	1.1e-06
4	Adipose	gene expression	Cad	0.06	0.06	1.1e-05	0.04	0.04	0.04	0.04	1.2e-05	1.1e-05	1.1e-05	1.2e-05
5	PL	gene expression	Cad	0.03	0.02	1.2e-03	0.03	0.02	0.01	0.02	4.1e-04	1.2e-03	7.3e-03	1.1e-03
6	LHb	gene expression	Cad	0.38	0.44	1.1e-03	0.08	0.13	0.11	0.09	6.3e-03	6.7e-04	1.3e-03	3.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	3.9	6.6	8.3	2.8	2.2	-2.9	2.4	-2.4	2.6
Area under the delay curve	0.1	0.1	0.4	-0.1	-0.1	0.1	-0.6	0.7	-0.3
BMI with tail	0.9	2.9	7.9	-1.2	-2.8	1.4	-1.9	1.7	-0.2
BMI without tail	0.2	0.3	0.8	-0.5	-0.9	0.6	-0.5	0.3	-0.5
Body weight	2.0	8.2	10.5	-2.8	-3.2	2.7	-3.1	2.9	-2.4
Weight adjusted by age	0.1	0.2	0.4	0.2	-0.1	-0.3	0.5	-0.6	0.3
Bone surface	1.7	3.1	4.5	1.9	1.0	-2.1	1.6	-1.6	2.0
Bone volume	1.9	3.2	4.6	2.0	1.5	-2.1	1.6	-1.6	1.8
Breakpoint value in progressive ratio session	1.1	1.2	1.9	1.2	0.9	-1.4	0.9	-1.0	1.1
Number of licking bursts	0.2	0.2	0.9	-0.1	-0.9	-0.0	-0.3	0.3	0.1
Context. condit. distance diff. score	0.0	0.0	0.1	-0.1	0.3	0.2	0.1	-0.1	-0.3
Locomotion velocity, session 1	0.3	0.3	1.0	-0.2	-1.0	0.2	-0.6	0.6	0.2
Locomotion distance, session 1	1.1	1.4	2.3	1.3	0.5	-1.4	1.1	-1.1	1.5
Locomotion velocity, session 2	0.2	0.3	0.5	-0.6	-0.4	0.6	-0.4	0.4	-0.7
Locomotion distance, session 2	0.0	0.0	0.2	-0.0	-0.5	0.1	0.0	-0.0	0.2
Locomotion velocity, session 3	1.0	1.2	1.7	1.0	0.6	-0.9	1.3	-1.3	1.3
Locomotion distance, session 3	0.9	1.0	2.0	1.0	0.1	-0.9	1.0	-1.0	1.4
Stereotopy head waving bouts, day 3	2.0	2.4	2.8	1.6	1.7	-1.6	1.5	-1.5	1.3
Stereotopy head waving duration, day 3	0.2	0.3	0.6	0.5	0.8	-0.5	0.5	-0.5	0.3
Locomotion velocity, session 7	0.8	0.9	1.5	1.1	0.2	-1.1	0.8	-0.8	1.2
Locomotion distance, session 7	0.2	0.2	0.9	0.2	-0.9	-0.2	0.1	-0.1	0.6
Stereotopy head waving bouts, day 7	0.0	0.0	0.1	-0.2	0.0	0.2	-0.2	0.2	-0.3
Stereotopy head waving duration, day 7	0.4	0.5	0.8	0.7	0.9	-0.7	0.6	-0.6	0.4
Locomotion velocity, session 8	0.3	0.4	0.8	0.6	0.9	-0.6	0.6	-0.6	0.1
Locomotion distance, session 8	0.2	0.2	0.3	0.5	0.5	-0.5	0.5	-0.5	0.3
Degree of sensitization distance	1.0	1.0	1.0	-0.9	-1.0	1.0	-1.0	1.0	-0.9
Degree of sensitization stereotypy	0.2	0.2	0.3	-0.5	-0.5	0.5	-0.5	0.5	-0.5
Conditioned locomotion	3.6	4.2	6.0	2.0	2.4	-2.0	2.1	-2.1	1.5
Cocaine response after cond. corrected	0.3	0.3	0.8	0.7	0.3	-0.9	-0.1	0.1	0.6
Cocaine response after cond. not corrected	0.8	0.9	1.6	1.2	0.9	-1.3	0.5	-0.5	1.0
Cocaine response before conditioning	2.0	2.4	3.7	1.3	1.9	-1.1	1.9	-1.8	1.1
Saline control response	0.8	1.0	1.3	1.0	1.1	-1.0	1.1	-1.1	0.7
Bone: connectivity density	3.9	6.1	7.9	2.7	1.8	-2.8	2.4	-2.3	2.8
Bone: cortical apparent density	0.4	0.6	1.1	0.6	0.6	-0.6	1.0	-1.0	0.5
Bone: cortical area	0.1	0.2	0.4	0.4	-0.3	-0.5	0.3	-0.3	0.6
Bone: cortical porosity	2.0	2.2	4.0	1.4	2.0	-1.3	1.5	-1.5	1.0
Bone: cortical porosity	1.4	1.5	3.1	1.2	1.8	-1.1	1.2	-1.2	0.8
Bone: cortical thickness	0.1	0.2	0.4	-0.4	-0.6	0.4	-0.5	0.5	-0.4
Bone: cortical thickness	1.2	1.3	1.7	1.2	0.8	-1.3	1.2	-1.2	1.1
Bone: cortical tissue density	0.3	0.4	0.9	0.5	0.5	-0.5	0.9	-0.9	0.4
Condit. Reinf. active minus inactive responses	1.0	1.2	2.0	-0.9	-1.4	0.9	-1.3	1.3	-0.5
Condit. Reinf. active-inactive response ratio	0.7	0.7	1.2	-0.8	-1.1	0.8	-0.9	0.9	-0.4
Condit. Reinf. active responses	0.1	0.1	0.2	0.2	-0.4	-0.2	-0.4	0.4	0.5
Condit. Reinf. inactive responses	0.7	0.9	1.4	1.2	0.8	-1.2	0.6	-0.6	1.0
Incentive salience index mean	0.1	0.2	0.3	0.0	-0.6	-0.1	-0.5	0.5	0.3
Condit. Reinf. lever presses	0.2	0.3	0.5	0.6	0.5	-0.7	0.1	-0.1	0.6
Condit. Reinf. active minus inactive responses	4.2	5.3	6.5	2.3	1.8	-2.2	2.4	-2.4	2.6
Condit. Reinf. active-inactive response ratio	0.9	0.9	1.1	1.1	1.0	-0.9	0.8	-0.8	1.1
Condit. Reinf. active responses	3.5	4.9	6.4	2.3	1.6	-2.1	2.3	-2.3	2.5
Condit. Reinf. inactive responses	1.9	2.3	3.1	1.5	0.9	-1.6	1.6	-1.6	1.8
Condit. Reinf. lever presses	2.1	2.8	3.7	1.6	1.6	-1.5	1.9	-1.9	1.4
Condit. Reinf. lever reinforcers received	3.2	4.6	5.8	2.2	1.5	-2.0	2.3	-2.3	2.4
Conditioned reinforcement - actives	2.1	2.1	4.0	1.3	2.0	-1.4	1.5	-1.5	0.6
Conditioned reinforcement - inactives	3.4	3.8	4.9	2.0	2.2	-1.8	1.9	-1.8	1.9
Conditioned locomotion	1.2	1.5	3.4	0.9	1.9	-1.0	1.3	-1.3	-0.1
Patch foraging indifference point 0 sec	0.4	0.7	1.9	-0.7	-1.4	0.6	-0.8	0.8	-0.2
Patch foraging indifference point AUC	1.7	2.0	3.3	1.6	0.5	-1.7	1.3	-1.3	1.8
Delay disc. indifference point, 0s delay	4.7	5.1	7.2	-2.1	-1.6	2.0	-2.6	2.7	-2.4
Delay disc. indifference point, 16s delay	0.0	0.0	0.1	0.2	0.0	-0.0	0.1	0.0	0.3
Delay disc. indifference point, 2s delay	0.5	0.6	0.9	-0.7	-0.4	0.6	-0.9	1.0	-0.9
Delay disc. indifference point, 24s delay	0.7	0.7	1.8	0.8	1.4	-0.8	0.8	-0.5	0.4
Delay disc. indifference point, 4s delay	0.3	0.3	0.7	-0.1	-0.4	0.2	-0.8	0.8	-0.1
Delay disc. indifference point, 8s delay	0.0	0.0	0.1	0.0	0.3	-0.1	-0.2	0.2	-0.2
Indifference point function ln k	0.2	0.3	1.1	-0.1	1.1	0.0	-0.0	0.0	-0.7
Indifference point function log k	0.2	0.3	1.1	-0.1	1.1	0.0	-0.0	0.0	-0.7
Patch foraging total patch changes 0 sec	0.4	0.6	2.0	-0.6	-1.4	0.5	-0.7	0.7	-0.2
Patch foraging total patch changes 12 sec	0.8	1.0	2.0	-1.0	-1.4	0.9	-0.9	0.9	-0.7
Patch foraging total patch changes 18 sec	0.2	0.3	1.3	-0.1	-1.1	-0.1	-0.3	0.3	0.4
Patch foraging total patch changes 24 sec	0.7	0.8	1.8	-0.9	-1.3	0.9	-0.7	0.7	-0.8
Patch foraging total patch changes 6 sec	0.3	0.5	2.0	-0.1	-1.4	0.3	-0.4	0.5	0.6
Patch foraging time to switch 0 sec	0.0	0.1	0.2	-0.1	-0.5	0.2	0.2	-0.2	0.4
Patch foraging water rate 0 sec	0.1	0.2	0.6	0.1	0.8	-0.4	0.2	-0.2	-0.5
Patch foraging water rate 12 sec	0.9	1.4	3.5	-1.5	-0.4	1.5	-0.1	0.3	-1.9
Patch foraging water rate 18 sec	0.5	0.7	2.2	-0.8	0.6	0.9	-0.1	0.2	-1.5
Patch foraging water rate 24 sec	1.3	1.8	3.8	-1.6	-0.7	1.4	-0.9	0.9	-2.0
Patch foraging water rate 6 sec	1.0	1.5	4.2	-1.4	-0.0	1.4	-0.7	0.8	-2.0
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.0	0.1	-0.2	0.1	-0.1	-0.1	0.1
Distance traveled before self-admin	0.1	0.1	0.3	-0.0	0.6	-0.0	0.1	0.0	-0.5
Distance traveled after self-admin	1.3	1.5	2.0	-1.1	-1.0	1.0	-1.4	1.4	-1.3
Extensor digitorum longus weight	4.1	15.9	17.3	4.2	3.4	-4.2	4.0	-4.0	4.2
Bone: elastic displacement	1.0	1.1	2.3	1.0	1.5	-1.2	0.9	-0.8	0.7
Bone: elastic work	0.9	1.1	1.7	1.1	1.0	-1.3	0.9	-0.9	1.1
Bone: endosteal estimation	0.3	0.7	1.3	0.9	0.1	-1.0	0.8	-0.8	1.2
Bone: endosteal perimeter	0.1	0.2	0.5	0.5	-0.2	-0.5	0.3	-0.3	0.7
Epididymis fat weight	13.0	30.2	33.8	-5.6	-5.8	5.4	-5.5	5.3	-5.2
Delta time in closed arm before/after self-admin	0.1	0.1	0.5	-0.2	-0.7	0.1	-0.1	0.2	0.1
Delta time in open arm before/after self-admin	0.4	0.4	0.7	0.7	0.3	-0.5	0.4	-0.6	0.9
Diff in mean of infusions in LGA sessions	0.2	0.2	0.5	0.5	0.2	-0.7	0.2	-0.3	0.5
Delay discount exponential model param	0.1	0.1	0.1	-0.2	-0.2	0.2	0.3	-0.4	-0.0
Extinction: sum of active levers before priming	0.4	0.4	0.7	0.6	0.3	-0.5	0.7	-0.9	0.8
Active lever presses in extinction session 6	0.8	0.8	1.0	1.0	1.0	-0.9	0.8	-0.9	0.7
Bone: final force	0.1	0.1	0.2	0.3	-0.1	-0.4	0.4	-0.4	0.2
Bone: final moment	0.1	0.1	0.2	0.4	-0.1	-0.5	0.4	-0.4	0.3
Food consumed during 24 hour testing period	0.1	0.1	0.2	0.3	-0.1	-0.4	-0.1	0.2	0.3
Glucose	0.2	0.3	0.5	-0.5	-0.4	0.4	-0.7	0.7	-0.4
Heart weight	8.0	11.4	14.6	-3.7	-2.6	3.8	-3.3	3.2	-3.5
Delay discount hyperbolic model param	0.1	0.1	0.2	-0.2	-0.1	0.2	0.3	-0.4	-0.1
Intermittent access intake day 1-15 change	0.4	0.4	0.9	0.3	1.0	-0.3	0.6	-0.8	-0.2
Intermittent access intake escalation	0.2	0.2	0.4	0.1	0.6	-0.1	0.3	-0.5	-0.3
Intermittent access intake escalation 2	0.2	0.2	0.3	-0.5	-0.5	0.6	-0.4	0.3	-0.4
Intermitt. access day 1 inactive lever presses	0.3	0.4	0.7	0.5	0.3	-0.3	0.7	-0.8	0.8
Intermitt. access day 15 inactive lever presses	7.9	8.6	13.2	3.2	1.9	-3.0	2.8	-2.7	3.6
Intermitt. access escalation Index	0.8	0.7	2.1	-0.4	-1.4	0.4	-0.9	1.0	0.3
Intermittent access day 1 total infusions	5.1	5.9	6.7	2.6	2.4	-2.4	2.4	-2.3	2.6
Intermittent access day 15 total infusions	2.6	2.9	4.1	1.7	2.0	-1.5	1.7	-1.8	1.4
Intermittent access terminal intake (last 3 days)	2.5	2.7	3.9	1.6	2.0	-1.4	1.7	-1.8	1.3
Intermittent access total infusions	2.9	3.3	5.4	1.7	2.3	-1.6	1.9	-1.9	1.3
Intermittent access day 1 locomotion	2.3	2.4	2.7	1.6	1.5	-1.3	1.6	-1.6	1.6
Intermittent access day 15 total locomotion	1.0	1.0	1.8	1.0	0.8	-0.9	1.1	-1.3	0.9
Intermittent access total locomotion	0.6	0.7	1.1	0.7	0.9	-0.6	1.0	-1.1	0.5
Intermittent access standard deviation	0.4	0.4	0.9	0.6	0.5	-0.6	0.8	-1.0	0.5
Left kidney weight	0.1	0.2	0.5	-0.2	0.7	0.1	0.1	-0.3	-0.6
Right kidney weight	1.1	3.0	4.2	-1.9	-0.9	1.9	-1.7	1.6	-2.0
Cocaine induced anxiety	0.4	0.4	0.7	0.7	0.3	-0.6	0.7	-0.7	0.8
Post-drug Anxiety	1.4	1.6	2.1	-1.1	-1.4	1.2	-1.3	1.4	-0.9
Baseline Anxiety	2.4	2.6	3.9	-1.5	-1.3	1.4	-1.8	2.0	-1.5
Tail length	0.1	0.3	1.5	-0.4	0.5	0.3	-0.0	-0.1	-1.2
Length with tail	1.2	4.4	8.2	-2.3	-1.1	2.1	-2.0	1.9	-2.9
Length without tail	0.8	1.8	2.4	-1.3	-1.0	1.2	-1.5	1.6	-1.2
Times rat made contact with spout	1.2	1.4	2.6	1.3	0.9	-1.6	1.0	-1.0	1.1
Lifetime Intake	3.9	4.4	6.6	2.1	2.6	-2.0	2.1	-2.1	1.6
Liver weight, left	1.7	2.7	3.6	-1.5	-1.4	1.3	-1.9	1.9	-1.7
Liver weight, right	8.7	14.5	15.8	-4.0	-3.6	3.9	-3.8	3.7	-3.8
Locomotor activity	0.7	1.1	1.9	-0.8	-1.4	0.7	-1.4	1.1	-0.4
Locomotor testing distance	0.2	0.3	0.8	0.3	-0.7	-0.3	-0.2	0.0	0.9
Locomotor testing rearing	1.0	1.6	2.4	1.3	0.5	-1.4	1.2	-1.3	1.5
Locomotion in novel chamber	0.7	0.8	1.0	-0.9	-0.6	1.0	-0.8	1.0	-1.0
Locomotion in novel chamber post-restriction	1.7	2.1	3.9	-1.5	-2.0	1.5	-1.3	1.2	-1.0
Fecal boli incidents, locomotor time 1	0.5	0.6	1.6	0.5	1.3	-0.4	0.8	-0.8	0.3
Change in fecal boli incidents, locomotor task	5.0	4.8	6.1	-2.1	-2.1	2.0	-2.5	2.4	-2.0
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.3	-0.3	0.4	0.3	-0.1	0.0	-0.6
Bouts of movement, locomotor time 1	1.7	1.8	2.3	1.5	0.7	-1.5	1.5	-1.3	1.5
Total resting periods, locomotor time 1	1.9	2.1	2.9	1.6	0.8	-1.6	1.4	-1.2	1.7
Rest time, locomotor task time 1	0.1	0.1	0.2	0.4	0.4	-0.3	0.2	-0.2	0.3
Distance moved, locomotor task time 1	1.1	1.2	1.5	-1.2	-0.8	1.2	-1.0	1.1	-1.1
Vertical activity count, locomotor time 1	0.7	0.8	1.1	-0.9	-0.5	0.9	-0.9	1.0	-0.8
Time >=10cm from walls, locomotor time 2	0.4	0.5	1.4	0.4	1.2	-0.5	0.6	-0.7	-0.3
Bouts of movement, locomotor time 2	0.2	0.2	0.3	-0.5	-0.6	0.5	-0.0	0.2	-0.6
Total resting periods, locomotor time 2	0.1	0.1	0.2	-0.1	-0.5	0.2	0.2	-0.1	-0.1
Rest time, locomotor task time 2	0.9	1.0	2.1	1.2	0.5	-1.1	0.7	-0.8	1.5
Distance moved, locomotor task time 2	0.7	0.8	1.7	-1.0	-0.2	0.9	-0.8	0.9	-1.3
Vertical activity count, locomotor time 2	0.4	0.4	1.4	-0.6	0.3	0.5	-0.5	0.6	-1.2
Light reinforcement 1	2.7	5.0	10.4	2.6	0.9	-2.4	1.8	-1.8	3.2
Light reinforcement 2	2.3	3.1	5.3	2.0	1.3	-1.9	1.4	-1.4	2.3
Bone: marrow area	0.4	0.8	1.4	0.9	0.2	-1.0	0.8	-0.8	1.2
Bone: maximum diameter	0.5	1.0	2.1	1.1	0.0	-1.1	0.9	-0.9	1.4
Bone: maximum force	0.0	0.0	0.1	0.1	-0.3	-0.2	0.1	-0.2	0.0
Bone: maximum moment	0.0	0.0	0.1	0.2	-0.2	-0.3	0.2	-0.2	0.2
Mean time between licks in bursts	2.6	3.6	4.0	-2.0	-1.6	1.9	-1.9	1.9	-2.0
Mean num. licks in bursts	0.3	0.3	1.1	0.5	1.0	-0.6	0.4	-0.4	0.2
Cd content in liver	0.1	0.2	0.6	-0.0	-0.8	-0.0	-0.3	0.3	0.3
Co content in liver	4.4	5.1	6.4	2.4	2.5	-2.5	2.1	-2.1	1.9
Cu content in liver	0.0	0.0	0.1	0.2	0.0	-0.2	0.1	-0.1	0.4
Fe content in liver	0.1	0.1	0.2	0.2	0.1	-0.0	0.3	-0.3	0.4
K content in liver	0.8	0.8	2.2	-0.4	-1.5	0.3	-1.0	1.0	-0.1
Mg content in liver	1.1	1.1	3.0	-0.6	-1.7	0.5	-1.2	1.2	-0.1
Mn content in liver	0.6	0.7	1.5	0.9	-0.2	-1.0	0.7	-0.7	1.2
Na content in liver	0.3	0.3	0.8	0.7	0.9	-0.6	0.2	-0.2	0.4
Rb content in liver	0.2	0.2	1.0	-0.1	-1.0	0.1	-0.3	0.3	0.4
Se content in liver	0.3	0.4	1.4	-0.5	-1.2	0.4	-0.5	0.5	-0.0
Sr content in liver	0.6	0.6	1.1	-0.5	-0.3	0.5	-1.0	1.0	-0.8
Zn content in liver	1.6	1.8	2.6	-1.3	-1.6	1.2	-1.4	1.3	-1.2
Bone: minimum diameter	0.2	0.4	1.5	-0.4	-1.2	0.4	-0.6	0.5	-0.1
Time in familiar zone, hab. session 1	1.0	0.9	1.2	-0.8	-1.1	0.7	-1.1	1.1	-0.7
Time in novel zone, hab. session 1	0.2	0.2	0.5	-0.5	-0.2	0.7	0.0	-0.0	-0.4
Total zone transitions, hab. session 1	0.0	0.1	0.1	0.2	0.3	-0.3	0.3	-0.3	0.0
Total locomotion distance, hab. session 1	0.2	0.2	0.8	0.4	0.9	-0.4	0.4	-0.4	-0.1
Locomotion velocity, hab. session 1	0.7	1.1	2.0	1.1	1.4	-1.1	0.9	-0.9	0.6
Time in familiar zone, hab. session 2	0.0	0.0	0.2	0.0	-0.4	-0.2	-0.1	0.1	0.1
Time in novel zone, hab. session 2	0.3	0.3	0.6	-0.6	-0.2	0.8	-0.4	0.4	-0.6
Total zone transitions, hab. session 2	0.1	0.1	0.3	0.2	-0.6	-0.3	0.0	-0.0	0.4
Total locomotion distance, hab. session 2	0.1	0.1	0.2	0.4	-0.3	-0.5	0.3	-0.3	0.4
Locomotion velocity, hab. session 2	0.2	0.3	0.5	0.6	-0.1	-0.7	0.5	-0.5	0.7
Novel to familiar place preference ratio	1.1	1.2	1.4	-1.1	-0.9	1.2	-1.0	1.0	-1.2
Novelty place preference	1.6	1.7	2.1	-1.4	-1.1	1.5	-1.2	1.2	-1.4
Time in novel zone, NPP test	1.7	1.8	2.5	-1.4	-1.1	1.6	-1.3	1.3	-1.4
Total zone transitions, NPP test	1.3	1.8	2.1	1.4	0.9	-1.3	1.5	-1.5	1.4
Total locomotion distance, NPP test	1.8	2.5	2.9	1.6	1.2	-1.5	1.7	-1.7	1.7
Locomotion velocity, NPP test	2.7	3.9	4.4	2.1	1.5	-2.1	2.0	-2.0	2.0
Intraocular pressure	5.8	8.0	8.9	-2.9	-3.0	2.9	-2.8	2.9	-2.5
Delta distance traveled before/after self-admin	1.6	1.7	2.6	-1.2	-1.6	1.2	-1.5	1.4	-0.9
Delta ambulatory time before/after self-admin	0.5	0.5	0.9	-0.5	-0.9	0.5	-0.9	0.8	-0.4
Parametrial fat weight	6.8	13.2	16.3	-3.6	-4.0	3.6	-3.8	3.7	-3.1
Pavlov. Cond. lever latency	1.4	1.7	2.7	-1.4	-0.7	1.4	-1.2	1.2	-1.6
Pavlov. Cond. magazine entry latency	0.0	0.0	0.2	0.1	-0.2	-0.1	0.1	-0.1	0.4
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	0.1	-0.0	-0.2	0.1	-0.1	0.3
Pavlov. Cond. index score	0.5	0.6	1.3	0.8	0.2	-0.9	0.7	-0.7	1.1
Pavlov. Cond. latency score	0.5	0.6	1.4	0.8	0.1	-0.9	0.7	-0.7	1.2
Pavlov. Cond. lever contacts	0.7	0.9	1.2	1.0	0.6	-1.1	0.9	-0.9	1.1
Pavlov. Cond. magazine entry number	0.3	0.4	0.9	-0.7	-0.1	0.7	-0.6	0.6	-1.0
Pavlov. Cond. intertrial magazine entries	1.1	1.3	2.3	1.2	1.5	-1.1	1.1	-1.1	0.9
Pavlov. Cond. lever-magazine prob. diff.	1.2	1.5	2.3	1.3	0.7	-1.3	1.2	-1.2	1.5
Pavlov. Cond. response bias	1.2	1.5	1.8	1.3	1.1	-1.3	1.2	-1.2	1.3
Pavlov. Cond. lever latency	1.4	1.8	2.2	-1.5	-1.4	1.4	-1.3	1.3	-1.2
Pavlov. Cond. magazine entry latency	0.3	0.4	0.6	0.6	0.4	-0.6	0.7	-0.7	0.6
Pavlov. Cond. change in total contacts	0.5	0.7	0.9	0.8	0.8	-0.8	0.9	-1.0	0.7
Pavlov. Cond. index score	1.1	1.4	1.8	1.2	1.1	-1.1	1.3	-1.3	0.9
Pavlov. Cond. latency score	1.1	1.4	1.9	1.1	1.1	-1.1	1.4	-1.4	0.9
Pavlov. Cond. lever contacts	0.6	0.8	1.0	1.0	0.9	-0.9	1.0	-1.0	0.7
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	-0.3	-0.2	0.3	-0.4	0.4	-0.3
Pavlov. Cond. intertrial magazine entries	3.0	4.0	4.6	-2.1	-2.1	2.1	-2.0	2.0	-1.8
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	1.3	1.0	0.9	-0.9	1.1	-1.1	0.8
Pavlov. Cond. response bias	1.2	1.6	1.9	1.4	1.2	-1.3	1.3	-1.3	1.1
Time in closed arm before self-admin	0.3	0.3	0.7	-0.6	-0.5	0.5	-0.4	0.3	-0.9
Time in closed arm after self-admin	0.8	0.8	1.3	-1.1	-0.9	0.9	-0.6	0.8	-1.1
Time in open arm before self-admin	0.0	0.0	0.1	-0.2	-0.0	0.3	-0.0	0.1	0.0
Time in open arm after self-admin	1.3	1.4	3.0	1.3	0.7	-1.1	1.0	-1.1	1.7
Bone: periosteal estimation	0.4	0.8	1.4	1.0	0.1	-1.0	0.8	-0.8	1.2
Bone: periosteal perimeter	0.1	0.1	0.2	0.4	-0.2	-0.4	0.2	-0.2	0.5
Bone: post-yield work	0.5	0.7	1.4	0.8	1.2	-0.9	0.8	-0.8	0.4
Progressive ratio test 1 active lever presses	2.2	2.2	3.0	1.5	1.7	-1.5	1.6	-1.4	1.2
Progressive ratio test 1 breakpoint	1.9	2.0	2.4	1.4	1.5	-1.4	1.5	-1.4	1.2
Progressive ratio test 1 inactive lever presses	5.7	6.2	7.2	2.5	2.7	-2.3	2.7	-2.6	2.2
Progressive ratio test 2 active lever presses	0.3	0.3	1.2	0.4	1.1	-0.4	0.5	-0.3	0.1
Progressive ratio test 2 breakpoint	0.4	0.4	1.4	0.5	1.2	-0.4	0.6	-0.5	0.2
Progressive ratio test 2 inactive lever presses	2.7	3.1	3.4	1.8	1.8	-1.7	1.8	-1.8	1.7
Incentive Sensitization - Responses	0.1	0.1	0.2	-0.2	0.5	0.3	-0.3	0.4	-0.3
Incentive Sensitization - Breakpoint	0.2	0.2	0.3	-0.4	0.2	0.5	-0.5	0.6	-0.5
Sum of active levers in priming session hrs 5-6	0.5	0.5	1.8	0.7	-0.5	-0.6	0.2	-0.4	1.3
Progressive ratio	0.2	0.2	0.5	0.4	0.2	-0.5	0.5	-0.7	0.3
Food seeking constrained by brief footshock	6.6	8.1	11.3	2.6	3.4	-2.5	3.0	-3.3	2.1
Seeking ratio, punishment vs. effort	0.5	0.7	1.4	0.7	1.2	-0.6	0.9	-0.8	0.6
Retroperitoneal fat weight	20.1	65.9	83.9	-8.3	-9.2	8.2	-8.0	7.8	-7.0
Reaction time number correct	0.4	0.6	0.7	0.8	0.7	-0.8	0.7	-0.7	0.8
Reaction time mean minus median	0.0	0.1	0.2	0.1	0.5	-0.1	0.1	-0.2	-0.1
Reaction time mean minus median AUC	0.0	0.0	0.1	-0.2	0.1	0.1	-0.2	0.2	-0.3
Reaction time num false alarms	0.5	0.7	2.6	0.0	-1.6	0.1	-0.4	0.4	1.1
Reaction time num false alarms AUC	0.5	0.7	2.6	0.0	-1.6	0.0	-0.5	0.5	1.1
Reaction time trials correct on left	0.4	0.6	0.7	0.8	0.7	-0.8	0.7	-0.7	0.8
Reaction time trials on left	0.4	0.6	0.8	0.8	0.7	-0.9	0.7	-0.8	0.8
Reaction time mean	0.9	1.3	2.8	-1.3	-0.1	1.4	-0.8	0.7	-1.7
Reaction time mean AUC	0.8	1.1	2.2	-1.2	-0.1	1.3	-0.8	0.7	-1.5
Median of all reaction times	1.1	1.6	3.2	-1.4	-0.2	1.6	-0.9	0.8	-1.8
Reaction time omissions	0.1	0.1	0.3	0.3	-0.5	-0.2	-0.4	0.3	0.5
Reaction time false alarm rate	0.7	0.9	3.4	-0.4	-1.8	0.4	-0.9	0.8	0.6
Reaction time premature initiation rate	0.2	0.2	0.3	-0.5	-0.5	0.6	-0.3	0.3	-0.5
Reaction time premature initiations	0.0	0.0	0.0	-0.0	-0.1	0.1	0.2	-0.2	-0.1
Std. dev. reaction times	0.2	0.3	0.8	-0.6	-0.0	0.6	-0.3	0.3	-0.9
Reaction time trials completed	0.4	0.6	0.8	0.8	0.7	-0.9	0.7	-0.8	0.8
Reaction time trials AUC	0.6	0.9	1.0	1.0	0.8	-1.0	0.9	-1.0	1.0
Run reversals in cocaine runway, females	0.2	0.2	0.4	-0.4	0.6	0.4	0.0	0.3	-0.7
Run reversals in cocaine runway, males	0.3	0.3	0.9	0.3	1.0	-0.4	0.5	-0.6	0.1
Latency to leave start box in cocaine runway	0.5	0.5	1.2	0.7	1.1	-0.8	0.5	-0.5	0.3
Latency to leave start box in cocaine runway, F	0.3	0.4	0.6	0.7	0.6	-0.7	0.4	-0.5	0.7
Latency to leave start box in cocaine runway, M	1.1	1.0	2.5	0.9	1.6	-1.0	1.0	-0.9	0.2
Std. dev. time between licks in bursts	0.4	0.5	1.0	-0.5	-1.0	0.4	-0.8	0.8	-0.5
Total sessions with >9 infusions	3.8	4.2	6.4	2.0	2.5	-2.1	2.1	-2.1	1.4
Short access day 1 total inactive lever presses	4.8	5.3	7.0	2.4	2.0	-2.2	2.3	-2.2	2.6
Short access day 10 total inactive lever presses	1.1	1.3	3.1	1.1	0.2	-1.0	1.1	-1.1	1.8
Short access day 1 total infusions	6.0	6.4	7.0	2.6	2.5	-2.6	2.6	-2.5	2.3
Short access day 10 total infusions	4.4	4.9	7.0	2.3	2.6	-2.2	2.2	-2.0	1.8
Short access total infusions	3.8	4.3	6.2	2.1	2.5	-2.0	2.1	-2.0	1.6
Short access day 1 locomotion	8.7	9.3	11.2	3.0	3.0	-3.0	3.3	-3.3	2.6
Short access day 10 total locomotion	1.1	1.2	2.1	1.0	1.2	-0.8	1.3	-1.4	0.8
Short access total locomotion	1.2	1.3	2.3	1.0	1.5	-0.9	1.2	-1.3	0.6
One hour access (0.3 mA shock)	1.8	2.1	2.3	1.5	1.5	-1.5	1.5	-1.5	1.3
Compulsive drug intake	1.5	1.5	3.3	-0.9	-1.8	0.8	-1.4	1.5	-0.2
One hour access (shock baseline)	2.9	3.3	6.1	1.6	2.5	-1.6	1.9	-2.0	0.9
Social response proportion	0.6	0.6	1.1	-0.5	-0.0	0.4	-1.1	1.0	-1.1
Social responses	0.2	0.2	0.4	-0.3	-0.6	0.2	-0.6	0.5	-0.5
Social time	0.3	0.4	1.4	-0.5	0.1	0.4	-0.5	0.3	-1.2
Soleus weight	3.3	9.8	11.6	3.3	2.9	-3.4	3.0	-3.0	3.1
Bone: stiffness	0.1	0.1	0.3	-0.2	-0.6	0.2	-0.1	0.1	-0.2
Tibialis anterior weight	3.1	10.7	13.9	3.4	2.2	-3.3	3.4	-3.4	3.7
Time to tail flick, vehicle, before self-admin	1.4	1.4	2.2	-1.4	-0.8	1.3	-1.0	0.9	-1.5
Time to tail flick, vehicle, after self-admin	3.6	3.8	4.3	-2.0	-1.9	1.7	-2.0	2.0	-2.1
Time to tail flick, test, before self-admin	0.8	0.8	1.4	0.8	1.2	-0.8	0.9	-0.8	0.7
Time to tail flick, test, after self-admin	0.2	0.2	0.5	-0.3	0.7	0.1	-0.2	0.2	-0.7
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.7	-0.1	-0.8	-0.1	-0.6	0.6	-0.0
Delta time to tail flick, test, before/after SA	0.3	0.3	0.8	0.5	0.9	-0.6	0.4	-0.5	0.1
Tibia length	2.3	6.5	7.2	-2.6	-2.1	2.6	-2.7	2.6	-2.7
Ambulatory time before self-admin	0.1	0.1	0.3	0.2	0.6	-0.1	0.4	-0.3	-0.1
Ambulatory time after self-admin	0.7	0.8	1.0	-0.9	-0.7	0.9	-0.9	0.9	-1.0
Bone: tissue strength	1.1	1.0	1.4	-1.0	-0.5	1.0	-1.1	1.1	-1.2
Total heroin consumption	2.5	2.9	3.4	1.7	1.3	-1.8	1.6	-1.8	1.8
Bone: trabecular number	2.9	4.5	6.0	2.4	1.9	-2.5	1.8	-1.8	2.2
Bone: trabecular spacing	2.7	3.5	5.3	-2.1	-1.4	2.3	-1.7	1.7	-2.0
Bone: trabecular thickness	0.6	0.7	1.2	0.9	0.8	-1.1	0.8	-0.8	0.6
Bone: trabecular tissue density	0.5	0.7	1.4	0.5	0.9	-0.4	1.2	-1.2	0.3
Water consumed over 24 hours	0.6	0.7	1.5	1.1	0.2	-1.2	0.3	-0.3	1.1
Number of responses in last shaping day	0.8	0.8	1.6	0.9	1.3	-0.9	0.9	-0.8	0.3