Hub : Genes

Cad

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain alternative TSS NM_001105710.2 0.11 0.1 3.1e-07 0.06 0.07 0.07 0.07 5.4e-06 4.6e-07 4.6e-07 5.5e-07
2 Brain alternative TSS XM_063261542.1 0.11 0.09 4.4e-07 0.06 0.07 0.07 0.07 6.7e-06 5.8e-07 6.6e-07 7.2e-07
3 IL gene expression Cad 0.83 0.06 7.3e-06 0.17 0.13 0.16 0.16 5.7e-05 4.6e-04 9.8e-05 1.1e-04
4 NAcc gene expression Cad 0.12 0.06 0.0e+00 0.11 0.12 0.12 0.12 7.4e-16 1.4e-17 3.4e-17 4.1e-17
5 PL gene expression Cad 0.02 0.02 1.4e-03 0.03 0.03 0.03 0.03 1.4e-04 8.1e-04 3.6e-04 2.6e-04
6 Brain isoform ratio NM_001105710.2 0.04 0.04 3.8e-04 0.01 0.03 0.02 0.02 2.0e-02 7.6e-04 9.3e-03 1.1e-02
7 Brain isoform ratio XM_063261542.1 0.04 0.04 3.8e-04 0.01 0.03 0.02 0.02 2.0e-02 7.3e-04 9.1e-03 1.0e-02
8 Brain gene expression Cad 0.08 0.06 1.9e-07 0.07 0.07 0.05 0.06 7.6e-07 8.7e-07 2.1e-05 2.3e-06
9 Adipose mRNA stability Cad 0.03 0.03 6.1e-03 0.02 0.02 0.02 0.02 3.4e-03 4.9e-03 3.9e-03 4.1e-03
10 Adipose gene expression Cad 0.06 0.06 7.2e-06 0.04 0.05 0.05 0.05 8.7e-06 7.5e-06 7.1e-06 7.3e-06
11 LHb gene expression Cad 0.27 0.27 1.2e-03 0.1 0.12 0.1 0.11 2.6e-03 8.5e-04 2.3e-03 1.3e-03
12 NAcc alternative TSS XM_063261542.1 0.1 0.07 7.9e-06 0.03 0.04 0.03 0.03 1.4e-05 3.1e-06 1.3e-05 1.1e-05
13 NAcc alternative TSS NM_001105710.2 0.1 0.08 8.5e-05 0.02 0.03 0.02 0.03 1.2e-04 2.9e-05 1.8e-04 9.0e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density3.56.58.8-2.72.7-1.82.4-2.0-2.82.9-3.02.92.72.92.0-2.0
Area under the delay curve0.10.10.6-0.20.2-0.40.20.2-0.20.2-0.80.20.20.20.1-0.1
BMI with tail0.51.86.51.5-1.52.5-1.41.41.1-1.11.0-1.0-0.9-0.5-1.31.3
BMI without tail0.52.66.11.7-1.72.5-1.71.91.5-1.51.5-1.2-1.3-1.0-1.51.4
Body weight2.410.412.63.4-3.43.4-3.43.63.2-3.23.0-3.0-3.1-2.8-3.13.1
Weight adjusted by age0.10.20.6-0.30.3-0.10.5-0.8-0.30.30.30.10.30.40.6-0.6
Bone surface1.63.15.6-1.81.8-0.61.5-0.9-2.12.1-2.22.32.02.41.0-1.0
Bone volume1.73.35.3-1.91.9-1.11.6-0.9-2.22.2-2.22.32.02.31.1-1.1
Breakpoint value in progressive ratio session0.61.01.7-0.90.9-0.91.1-0.5-0.90.9-1.30.81.01.01.3-1.3
Number of licking bursts0.10.21.10.2-0.21.1-0.40.6-0.00.1-0.50.20.00.4-0.60.6
Context. condit. distance diff. score0.00.00.1-0.20.2-0.30.1-0.3-0.10.1-0.00.10.0-0.10.1-0.1
Locomotion velocity, session 10.10.10.60.2-0.20.3-0.40.80.1-0.10.30.0-0.10.0-0.60.6
Locomotion distance, session 11.11.42.6-1.31.3-0.70.9-0.4-1.51.5-1.51.61.31.50.5-0.5
Locomotion velocity, session 20.30.30.60.5-0.50.2-0.60.60.5-0.50.4-0.6-0.6-0.6-0.70.8
Locomotion distance, session 20.00.00.20.0-0.00.3-0.20.5-0.00.00.10.1-0.00.1-0.30.3
Locomotion velocity, session 30.91.01.7-0.90.9-0.41.1-1.3-0.90.9-0.80.91.01.01.3-1.3
Locomotion distance, session 30.60.61.2-0.80.80.10.7-0.4-0.90.9-1.01.01.01.10.6-0.6
Stereotopy head waving bouts, day 32.32.73.7-1.61.6-1.31.8-1.9-1.61.6-1.41.51.61.51.9-1.9
Stereotopy head waving duration, day 30.30.40.9-0.50.5-0.60.7-0.8-0.40.4-0.30.40.50.40.9-0.9
Locomotion velocity, session 70.80.92.1-0.90.90.30.9-0.3-1.11.1-0.91.21.21.40.8-0.8
Locomotion distance, session 70.20.21.20.1-0.11.1-0.21.0-0.20.20.10.40.20.6-0.20.2
Stereotopy head waving bouts, day 70.00.00.2-0.00.00.40.0-0.5-0.10.1-0.30.10.10.20.0-0.0
Stereotopy head waving duration, day 70.50.61.9-0.70.7-0.70.8-1.4-0.60.6-0.70.50.60.50.9-0.9
Locomotion velocity, session 80.30.40.8-0.70.7-0.90.6-0.6-0.60.6-0.10.60.50.40.6-0.6
Locomotion distance, session 80.20.30.6-0.70.7-0.50.5-0.3-0.70.7-0.60.80.60.60.3-0.2
Degree of sensitization distance1.01.11.71.1-1.11.2-1.11.30.9-0.91.0-0.8-0.9-0.7-1.11.1
Degree of sensitization stereotypy0.20.30.70.6-0.50.8-0.5-0.00.5-0.50.2-0.5-0.5-0.5-0.50.5
Conditioned locomotion3.33.95.0-2.12.1-2.22.1-2.2-1.91.9-1.81.81.81.62.0-1.9
Cocaine response after cond. corrected0.30.51.1-0.70.7-0.50.6-0.1-0.80.8-1.00.90.70.90.4-0.4
Cocaine response after cond. not corrected0.91.42.0-1.21.2-1.21.0-0.8-1.31.3-1.41.41.21.30.7-0.7
Cocaine response before conditioning1.92.24.5-1.61.6-2.11.5-2.1-1.41.4-1.01.21.31.01.3-1.2
Saline control response0.70.92.1-1.01.0-0.91.0-1.5-1.01.0-0.50.90.90.81.0-0.9
Bone: connectivity density3.55.57.9-2.42.4-1.22.2-1.8-2.62.6-2.82.72.62.81.9-1.9
Bone: cortical apparent density0.30.40.8-0.60.6-0.20.5-0.4-0.70.7-0.90.80.70.80.3-0.3
Bone: cortical area0.30.61.4-0.60.60.50.40.1-0.90.9-1.01.10.91.20.1-0.1
Bone: cortical porosity1.61.83.3-1.41.4-1.81.4-1.8-1.21.2-0.91.11.20.91.4-1.3
Bone: cortical porosity1.61.82.9-1.41.4-1.71.4-1.5-1.31.3-1.01.31.31.01.4-1.3
Bone: cortical thickness0.10.20.70.2-0.20.8-0.50.50.0-0.0-0.10.1-0.20.1-0.80.8
Bone: cortical thickness1.01.32.0-1.21.2-0.51.0-0.6-1.31.3-1.31.41.31.40.9-0.9
Bone: cortical tissue density0.20.30.6-0.50.5-0.10.4-0.2-0.60.6-0.80.70.50.70.2-0.2
Condit. Reinf. active minus inactive responses1.01.11.91.1-1.11.4-1.11.40.9-0.90.7-1.0-0.9-0.6-1.11.1
Condit. Reinf. active-inactive response ratio1.01.02.31.1-1.11.3-1.01.51.0-1.00.7-1.0-0.9-0.7-0.90.9
Condit. Reinf. active responses0.10.10.4-0.20.20.00.10.2-0.30.3-0.70.30.30.5-0.10.1
Condit. Reinf. inactive responses1.31.72.4-1.41.4-1.21.1-1.1-1.41.4-1.51.51.31.30.9-0.9
Incentive salience index mean0.10.10.40.2-0.20.5-0.20.6-0.00.0-0.3-0.00.00.3-0.30.3
Condit. Reinf. lever presses0.50.71.2-0.90.9-0.80.7-0.4-0.90.9-1.10.90.80.90.5-0.5
Condit. Reinf. active minus inactive responses3.55.48.8-2.22.2-1.92.4-3.0-2.22.2-2.42.02.32.12.5-2.5
Condit. Reinf. active-inactive response ratio1.01.65.0-1.21.2-1.21.2-2.2-1.11.1-1.11.01.10.91.3-1.2
Condit. Reinf. active responses3.24.65.8-2.02.0-1.52.2-2.3-2.12.1-2.41.92.22.12.3-2.3
Condit. Reinf. inactive responses1.11.72.9-1.21.2-0.61.3-0.5-1.41.4-1.71.31.41.61.4-1.4
Condit. Reinf. lever presses2.02.94.2-1.71.7-1.61.7-2.0-1.61.6-2.01.61.61.51.7-1.7
Condit. Reinf. lever reinforcers received3.04.25.6-1.92.0-1.42.2-2.4-2.02.0-2.31.82.12.02.3-2.2
Conditioned reinforcement - actives0.93.67.4-1.81.8-2.72.1-2.4-1.51.4-0.61.41.51.02.5-2.6
Conditioned reinforcement - inactives1.54.25.2-2.22.2-2.32.1-2.2-2.12.1-2.02.02.01.91.7-1.6
Conditioned locomotion0.81.23.4-0.80.8-1.61.2-1.4-0.50.50.90.40.60.11.7-1.8
Patch foraging indifference point 0 sec0.30.92.41.0-1.01.6-0.90.80.9-0.90.8-1.0-0.7-0.6-0.80.8
Patch foraging indifference point AUC0.61.33.0-1.21.2-0.20.8-0.3-1.41.4-1.31.71.41.60.6-0.7
Delay disc. indifference point, 0s delay3.13.55.71.8-1.80.9-1.92.41.9-1.91.1-1.9-2.0-2.0-2.12.1
Delay disc. indifference point, 16s delay0.10.10.6-0.20.2-0.10.2-0.3-0.20.2-0.80.20.20.20.1-0.1
Delay disc. indifference point, 2s delay0.20.20.40.4-0.40.2-0.50.60.4-0.40.3-0.4-0.5-0.4-0.60.6
Delay disc. indifference point, 24s delay0.81.24.4-1.01.0-1.61.0-1.0-0.90.9-2.10.80.80.80.9-0.9
Delay disc. indifference point, 4s delay0.00.00.40.0-0.00.1-0.10.7-0.10.1-0.10.10.00.2-0.20.2
Delay disc. indifference point, 8s delay0.00.10.5-0.10.1-0.50.2-0.0-0.10.1-0.70.00.00.10.2-0.2
Indifference point function ln k0.10.21.0-0.30.3-1.00.5-0.7-0.10.10.1-0.10.1-0.20.5-0.5
Indifference point function log k0.10.21.0-0.30.3-1.00.5-0.7-0.10.10.1-0.10.1-0.20.5-0.5
Patch foraging total patch changes 0 sec0.30.92.71.0-1.01.6-0.90.80.9-0.90.7-0.9-0.7-0.5-0.80.8
Patch foraging total patch changes 12 sec1.21.53.01.3-1.31.7-1.31.41.2-1.21.2-1.0-1.1-0.9-1.21.2
Patch foraging total patch changes 18 sec0.20.42.50.6-0.61.6-0.60.70.3-0.30.4-0.2-0.20.1-0.50.5
Patch foraging total patch changes 24 sec0.41.32.21.2-1.21.4-1.20.91.1-1.11.5-1.0-1.1-1.0-1.11.1
Patch foraging total patch changes 6 sec0.30.52.90.7-0.71.7-0.60.90.4-0.40.2-0.3-0.20.0-0.50.5
Patch foraging time to switch 0 sec0.00.10.90.4-0.40.9-0.20.10.2-0.2-0.0-0.2-0.20.00.00.0
Patch foraging water rate 0 sec0.10.21.3-0.40.4-1.10.4-0.6-0.20.20.20.10.2-0.20.3-0.4
Patch foraging water rate 12 sec0.41.53.01.2-1.20.2-1.10.71.4-1.41.5-1.4-1.4-1.7-1.01.0
Patch foraging water rate 18 sec0.20.51.70.5-0.5-0.7-0.4-0.10.8-0.80.9-0.9-0.9-1.3-0.30.4
Patch foraging water rate 24 sec1.62.23.91.5-1.50.6-1.30.91.8-1.81.8-1.9-1.7-2.0-1.00.9
Patch foraging water rate 6 sec0.91.32.90.9-0.9-0.6-1.00.61.2-1.21.5-1.3-1.3-1.7-1.01.0
Seeking ratio, delayed vs. immediate footshock0.00.10.60.1-0.10.0-0.10.10.1-0.10.80.1-0.1-0.10.00.0
Distance traveled before self-admin0.00.10.6-0.10.1-0.8-0.20.20.1-0.10.1-0.1-0.2-0.4-0.40.4
Distance traveled after self-admin1.42.53.61.5-1.51.1-1.81.81.5-1.51.5-1.4-1.5-1.6-1.91.9
Extensor digitorum longus weight4.216.718.9-4.24.2-3.34.1-4.2-4.24.2-4.34.24.24.14.0-3.9
Bone: elastic displacement0.81.02.2-1.01.0-1.51.1-0.9-0.80.8-0.90.60.80.61.2-1.2
Bone: elastic work0.81.11.7-1.11.1-1.01.1-0.6-1.11.1-1.30.91.11.11.0-1.1
Bone: endosteal estimation0.41.02.1-1.01.0-0.30.9-0.1-1.21.2-1.11.31.21.40.8-0.9
Bone: endosteal perimeter0.20.40.9-0.60.6-0.00.50.2-0.70.7-0.80.80.70.90.5-0.5
Epididymis fat weight10.854.762.47.9-7.97.2-7.47.47.8-7.87.4-7.7-7.4-7.1-6.66.5
Delta time in closed arm before/after self-admin0.10.10.60.1-0.10.8-0.1-0.0-0.00.0-0.20.20.10.30.0-0.1
Delta time in open arm before/after self-admin0.10.10.3-0.30.3-0.10.4-0.3-0.30.3-0.30.30.40.40.6-0.5
Diff in mean of infusions in LGA sessions0.00.00.1-0.00.00.20.10.3-0.10.1-0.20.00.20.30.2-0.2
Delay discount exponential model param0.20.31.10.5-0.50.7-0.50.20.5-0.51.1-0.5-0.5-0.6-0.40.5
Extinction: sum of active levers before priming0.20.31.1-0.40.4-0.30.5-0.5-0.50.5-1.00.40.60.70.5-0.5
Active lever presses in extinction session 61.01.02.4-0.90.9-1.21.2-0.8-0.80.8-0.20.61.00.71.5-1.5
Bone: final force0.10.10.3-0.20.20.40.10.3-0.40.4-0.30.50.30.50.0-0.1
Bone: final moment0.10.20.4-0.30.30.30.10.4-0.40.4-0.50.60.40.60.0-0.1
Food consumed during 24 hour testing period0.10.20.4-0.40.40.00.3-0.3-0.50.5-0.60.50.40.50.1-0.1
Glucose0.30.40.70.7-0.70.9-0.70.50.6-0.60.8-0.6-0.6-0.5-0.70.7
Heart weight3.14.97.02.1-2.11.8-2.42.32.1-2.12.3-2.0-2.2-2.1-2.62.6
Delay discount hyperbolic model param0.10.20.70.3-0.30.4-0.3-0.10.4-0.40.8-0.4-0.3-0.5-0.30.3
Intermittent access intake day 1-15 change0.00.30.8-0.50.5-0.90.3-0.7-0.30.30.20.50.40.00.6-0.8
Intermittent access intake escalation0.00.10.4-0.20.2-0.60.0-0.3-0.00.00.40.20.1-0.30.3-0.4
Intermittent access intake escalation 20.00.00.2-0.10.1-0.1-0.2-0.2-0.10.10.40.30.1-0.1-0.20.1
Intermitt. access day 1 inactive lever presses0.11.73.2-1.41.4-1.21.4-1.8-1.31.3-0.91.11.21.21.3-1.2
Intermitt. access day 15 inactive lever presses1.26.38.9-2.72.7-1.52.4-2.3-2.92.9-2.12.92.83.02.0-1.9
Intermitt. access escalation Index0.41.47.21.1-1.12.7-1.31.40.7-0.60.9-0.4-0.5-0.0-1.21.2
Intermittent access day 1 total infusions1.75.16.4-2.42.4-2.22.5-2.2-2.32.3-2.22.02.22.22.3-2.2
Intermittent access day 15 total infusions1.02.43.3-1.71.7-1.81.6-1.5-1.51.5-1.11.51.51.31.7-1.7
Intermittent access terminal intake (last 3 days)2.03.44.6-2.02.0-2.11.9-1.9-1.81.8-1.41.71.81.52.0-2.0
Intermittent access total infusions2.83.45.3-1.81.8-2.32.1-2.0-1.61.6-1.41.31.61.32.2-2.2
Intermittent access day 1 locomotion1.32.53.0-1.61.6-1.61.7-1.7-1.51.5-1.61.31.51.41.7-1.6
Intermittent access day 15 total locomotion0.10.40.9-0.60.6-0.60.8-1.0-0.50.5-0.30.40.60.50.8-0.8
Intermittent access total locomotion0.60.71.7-0.70.7-1.21.1-1.1-0.60.5-0.40.30.60.41.3-1.3
Intermittent access standard deviation0.31.61.9-1.31.3-1.21.4-1.2-1.31.3-1.11.31.31.21.4-1.4
Left kidney weight0.00.00.10.2-0.20.0-0.10.30.2-0.20.1-0.2-0.2-0.20.0-0.0
Right kidney weight0.32.12.61.5-1.51.2-1.51.61.5-1.50.7-1.5-1.5-1.5-1.51.5
Cocaine induced anxiety0.10.30.5-0.50.5-0.20.4-0.6-0.60.6-0.30.70.60.70.4-0.4
Post-drug Anxiety1.31.51.91.2-1.21.2-1.31.41.2-1.11.1-1.0-1.2-1.0-1.41.4
Baseline Anxiety2.44.06.12.1-2.11.8-2.02.52.0-2.01.7-2.0-2.1-1.9-1.91.9
Tail length0.31.42.21.1-1.10.4-1.21.51.3-1.31.4-1.0-1.3-1.5-1.00.9
Length with tail1.56.89.72.6-2.61.2-2.52.62.9-2.92.9-2.8-2.9-3.1-2.22.1
Length without tail0.41.92.61.4-1.40.8-1.31.51.5-1.51.5-1.6-1.5-1.5-1.21.2
Times rat made contact with spout1.61.83.4-1.31.3-0.91.3-1.3-1.41.4-1.81.41.41.51.1-1.1
Lifetime Intake2.93.75.6-1.91.9-2.42.2-2.0-1.71.7-1.31.41.71.42.3-2.3
Liver weight, left3.66.38.02.5-2.52.0-2.52.82.5-2.52.4-2.5-2.5-2.5-2.52.5
Liver weight, right9.115.817.64.0-4.03.1-4.03.74.2-4.24.2-4.2-4.1-4.2-3.83.9
Locomotor activity0.40.61.70.9-0.91.3-0.80.90.7-0.70.0-0.7-0.7-0.4-0.70.8
Locomotor testing distance0.10.20.9-0.10.10.90.3-0.2-0.30.3-0.80.40.50.80.4-0.5
Locomotor testing rearing0.41.33.6-0.80.8-0.11.3-1.3-0.90.9-0.90.81.21.21.8-1.9
Locomotion in novel chamber0.20.21.00.3-0.30.2-0.10.10.4-0.41.0-0.3-0.3-0.40.6-0.7
Locomotion in novel chamber post-restriction1.44.35.42.3-2.32.1-2.01.62.3-2.32.1-2.3-2.2-2.1-1.61.6
Fecal boli incidents, locomotor time 10.10.40.5-0.70.7-0.70.6-0.7-0.60.6-0.40.60.60.40.6-0.6
Change in fecal boli incidents, locomotor task4.14.46.62.2-2.21.7-2.12.62.1-2.12.0-2.2-2.1-2.0-2.02.0
Time >=10cm from walls, locomotor time 10.10.10.30.1-0.1-0.6-0.10.10.3-0.3-0.3-0.5-0.4-0.5-0.20.2
Bouts of movement, locomotor time 11.21.62.5-1.21.2-0.11.1-1.5-1.41.4-1.21.61.41.61.0-1.1
Total resting periods, locomotor time 11.61.83.0-1.31.3-0.11.2-1.4-1.51.5-1.31.71.51.71.2-1.2
Rest time, locomotor task time 10.00.10.40.2-0.20.3-0.20.50.2-0.20.6-0.2-0.2-0.2-0.10.1
Distance moved, locomotor task time 10.41.01.51.0-1.00.4-1.00.91.1-1.10.7-1.2-1.1-1.2-1.11.1
Vertical activity count, locomotor time 10.10.50.70.6-0.60.1-0.70.80.7-0.70.2-0.8-0.7-0.8-0.80.8
Time >=10cm from walls, locomotor time 20.20.52.4-0.80.8-1.60.7-0.7-0.60.6-0.40.60.40.20.7-0.7
Bouts of movement, locomotor time 20.00.20.60.4-0.40.8-0.5-0.20.3-0.30.1-0.1-0.4-0.2-0.60.5
Total resting periods, locomotor time 20.00.10.50.1-0.10.7-0.2-0.5-0.10.1-0.10.3-0.00.2-0.30.2
Rest time, locomotor task time 20.71.22.0-1.11.1-0.21.0-0.7-1.21.2-1.31.31.21.40.9-0.9
Distance moved, locomotor task time 20.70.91.60.9-0.9-0.1-0.90.81.1-1.11.3-1.2-1.1-1.3-0.80.8
Vertical activity count, locomotor time 20.20.51.10.5-0.5-0.5-0.50.60.7-0.71.1-0.8-0.7-1.0-0.40.4
Light reinforcement 11.25.29.0-2.22.2-0.22.0-2.0-2.62.6-2.72.82.63.01.7-1.6
Light reinforcement 21.63.65.6-2.02.0-0.91.7-1.6-2.22.2-2.42.32.02.21.2-1.1
Bone: marrow area0.41.02.0-1.01.0-0.30.9-0.1-1.21.2-1.11.31.21.40.8-0.9
Bone: maximum diameter0.71.43.3-1.11.10.30.9-0.2-1.41.4-1.61.61.41.80.7-0.8
Bone: maximum force0.10.20.3-0.40.4-0.00.3-0.1-0.50.5-0.50.60.50.60.3-0.3
Bone: maximum moment0.10.30.5-0.50.5-0.10.4-0.1-0.60.6-0.60.70.60.70.3-0.3
Mean time between licks in bursts0.63.74.01.9-1.91.7-2.02.02.0-2.01.8-2.0-1.9-1.9-2.02.0
Mean num. licks in bursts0.20.41.4-0.70.7-1.20.7-0.9-0.50.5-0.30.40.40.20.8-0.8
Cd content in liver0.00.00.20.1-0.10.4-0.10.1-0.00.00.00.10.10.2-0.10.0
Co content in liver5.46.37.8-2.72.7-2.52.5-2.1-2.72.7-2.82.72.52.52.1-2.1
Cu content in liver0.20.20.9-0.50.5-0.90.4-0.3-0.30.3-0.30.30.40.20.4-0.4
Fe content in liver1.21.52.8-1.21.2-1.41.4-1.0-1.11.1-0.70.91.31.01.7-1.6
K content in liver0.30.30.8-0.40.40.50.10.8-0.60.6-0.60.80.60.9-0.20.1
Mg content in liver0.30.40.9-0.30.30.60.10.8-0.60.6-0.70.80.61.0-0.20.2
Mn content in liver0.20.32.00.1-0.11.4-0.00.6-0.20.2-0.00.30.40.70.1-0.2
Na content in liver0.70.82.8-1.01.0-1.70.9-0.7-0.90.9-0.70.80.80.50.8-0.7
Rb content in liver0.10.10.40.1-0.10.7-0.10.6-0.00.0-0.20.10.20.3-0.10.1
Se content in liver0.10.10.40.3-0.30.5-0.20.10.3-0.30.7-0.3-0.2-0.20.1-0.1
Sr content in liver0.20.20.40.2-0.2-0.7-0.30.20.3-0.30.2-0.4-0.5-0.6-0.40.4
Zn content in liver1.01.12.61.0-1.00.9-1.11.60.9-0.91.0-0.9-0.9-0.9-1.21.2
Bone: minimum diameter0.20.41.70.5-0.51.3-0.61.20.3-0.20.3-0.1-0.20.1-0.70.7
Time in familiar zone, hab. session 10.80.81.80.9-0.91.1-1.01.30.8-0.81.0-0.7-0.7-0.6-0.90.9
Time in novel zone, hab. session 10.30.40.90.7-0.70.6-0.3-0.20.8-0.80.7-0.9-0.7-0.80.0-0.0
Total zone transitions, hab. session 10.10.10.2-0.30.3-0.30.3-0.3-0.40.4-0.40.40.30.30.1-0.1
Total locomotion distance, hab. session 10.10.20.3-0.50.5-0.50.3-0.1-0.50.5-0.40.50.40.40.2-0.2
Locomotion velocity, hab. session 10.81.21.7-1.21.2-1.20.9-0.7-1.21.2-1.31.31.11.10.6-0.6
Time in familiar zone, hab. session 20.00.00.30.1-0.10.5-0.1-0.1-0.00.00.10.20.00.2-0.10.0
Time in novel zone, hab. session 20.40.40.80.6-0.60.2-0.60.80.7-0.70.5-0.9-0.7-0.8-0.50.5
Total zone transitions, hab. session 20.10.10.4-0.10.10.6-0.00.3-0.20.2-0.50.30.20.5-0.20.2
Total locomotion distance, hab. session 20.10.10.3-0.30.30.40.00.0-0.40.4-0.60.60.40.6-0.20.2
Locomotion velocity, hab. session 20.20.30.7-0.50.50.20.3-0.2-0.60.7-0.80.80.60.80.0-0.0
Novel to familiar place preference ratio0.91.21.31.1-1.11.1-1.11.01.1-1.10.8-1.1-1.1-1.0-1.21.1
Novelty place preference1.41.82.01.4-1.41.3-1.41.21.4-1.41.1-1.4-1.4-1.3-1.41.3
Time in novel zone, NPP test1.61.92.21.5-1.51.4-1.41.21.5-1.51.2-1.5-1.4-1.4-1.31.3
Total zone transitions, NPP test1.21.82.3-1.51.5-1.11.3-1.2-1.51.5-1.51.51.41.41.1-1.0
Total locomotion distance, NPP test1.72.42.8-1.61.6-1.31.5-1.5-1.71.7-1.71.71.61.61.3-1.3
Locomotion velocity, NPP test2.73.85.0-2.12.1-1.61.9-1.8-2.12.1-2.22.22.02.11.6-1.6
Intraocular pressure5.28.59.83.1-3.13.0-3.02.73.0-3.02.4-3.0-3.0-2.7-2.92.9
Delta distance traveled before/after self-admin1.81.92.91.5-1.51.7-1.51.41.3-1.31.6-1.1-1.2-1.1-1.41.4
Delta ambulatory time before/after self-admin0.20.41.20.6-0.61.1-0.70.80.4-0.40.6-0.2-0.3-0.2-0.70.7
Parametrial fat weight13.030.738.05.6-5.65.8-6.05.55.3-5.35.3-4.8-5.3-4.8-6.26.1
Pavlov. Cond. lever latency1.31.72.51.3-1.30.9-1.20.91.5-1.51.6-1.5-1.4-1.6-0.90.8
Pavlov. Cond. magazine entry latency0.00.10.2-0.20.2-0.10.1-0.1-0.30.3-0.20.30.30.4-0.00.0
Pavlov. Cond. change in total contacts0.00.00.2-0.20.2-0.40.10.1-0.20.2-0.20.20.20.2-0.10.1
Pavlov. Cond. index score0.50.61.2-0.80.8-0.40.6-0.4-0.90.9-1.01.00.91.10.3-0.2
Pavlov. Cond. latency score0.50.61.3-0.70.7-0.20.5-0.4-0.90.9-1.01.00.91.10.3-0.2
Pavlov. Cond. lever contacts0.81.01.5-1.11.1-0.80.9-0.6-1.21.2-1.21.21.11.20.6-0.5
Pavlov. Cond. magazine entry number0.30.40.80.6-0.60.4-0.50.40.8-0.80.7-0.8-0.8-0.9-0.20.2
Pavlov. Cond. intertrial magazine entries1.31.62.2-1.31.3-1.51.3-1.2-1.21.2-1.41.11.21.11.3-1.3
Pavlov. Cond. lever-magazine prob. diff.1.01.32.0-1.21.2-0.81.0-0.8-1.31.3-1.41.31.31.40.7-0.7
Pavlov. Cond. response bias1.11.41.8-1.31.3-1.11.1-0.9-1.31.3-1.21.31.31.30.8-0.8
Pavlov. Cond. lever latency1.42.02.91.4-1.41.3-1.41.51.4-1.41.7-1.4-1.3-1.3-1.41.4
Pavlov. Cond. magazine entry latency0.20.30.4-0.60.6-0.50.5-0.5-0.60.6-0.50.60.60.60.5-0.5
Pavlov. Cond. change in total contacts0.41.01.7-0.90.9-0.81.0-1.1-1.01.0-1.31.00.90.91.0-1.1
Pavlov. Cond. index score1.01.62.0-1.31.3-1.21.3-1.3-1.21.2-1.41.31.21.11.2-1.3
Pavlov. Cond. latency score1.01.61.9-1.31.3-1.31.3-1.4-1.31.3-1.41.31.21.11.2-1.2
Pavlov. Cond. lever contacts0.91.42.3-1.21.2-1.01.2-1.3-1.11.1-1.51.21.11.11.2-1.2
Pavlov. Cond. magazine entry number0.10.20.30.4-0.40.4-0.40.30.5-0.50.6-0.5-0.4-0.4-0.30.3
Pavlov. Cond. intertrial magazine entries2.45.25.92.4-2.42.4-2.32.22.4-2.42.1-2.3-2.3-2.2-2.12.0
Pavlov. Cond. lever-magazine prob. diff.0.71.01.4-1.01.0-0.91.0-1.0-1.01.0-1.21.11.01.00.9-1.0
Pavlov. Cond. response bias1.72.33.3-1.51.5-1.41.5-1.6-1.51.5-1.81.51.41.41.4-1.5
Time in closed arm before self-admin0.50.91.41.0-1.00.9-0.80.81.0-1.01.2-1.1-1.1-1.0-0.70.7
Time in closed arm after self-admin1.01.21.71.2-1.21.2-0.90.81.2-1.21.3-1.3-1.1-1.1-0.60.6
Time in open arm before self-admin0.00.10.4-0.20.2-0.10.1-0.2-0.20.2-0.60.10.20.2-0.10.1
Time in open arm after self-admin1.21.32.0-1.21.2-0.61.0-0.9-1.31.3-1.41.31.21.40.9-0.8
Bone: periosteal estimation0.61.43.1-1.21.2-0.11.0-0.2-1.41.5-1.51.61.41.70.7-0.7
Bone: periosteal perimeter0.30.51.1-0.70.70.00.5-0.0-0.90.9-1.01.00.81.10.3-0.4
Bone: post-yield work1.01.83.0-1.31.3-1.71.4-1.7-1.21.2-1.01.21.21.01.4-1.4
Progressive ratio test 1 active lever presses1.22.13.9-1.51.5-2.01.7-1.4-1.31.3-1.20.91.21.11.7-1.6
Progressive ratio test 1 breakpoint1.22.14.0-1.51.5-2.01.8-1.5-1.31.3-1.30.91.21.11.7-1.6
Progressive ratio test 1 inactive lever presses1.95.06.7-2.32.3-2.62.5-2.5-2.12.1-1.41.92.11.82.5-2.4
Progressive ratio test 2 active lever presses0.60.83.1-0.80.8-1.81.0-1.0-0.50.5-0.20.30.50.11.2-1.2
Progressive ratio test 2 breakpoint0.50.62.8-0.70.7-1.70.9-0.9-0.40.4-0.10.20.40.01.0-1.0
Progressive ratio test 2 inactive lever presses0.82.64.5-1.71.7-2.11.8-1.8-1.51.5-0.71.41.51.21.8-1.8
Incentive Sensitization - Responses0.10.31.1-0.60.6-1.00.5-0.6-0.40.4-0.10.50.50.10.7-0.7
Incentive Sensitization - Breakpoint0.10.20.7-0.40.4-0.90.3-0.4-0.30.30.10.40.4-0.00.5-0.5
Sum of active levers in priming session hrs 5-60.40.41.1-0.30.30.70.10.3-0.60.6-1.00.80.61.0-0.10.1
Progressive ratio0.00.00.20.1-0.10.2-0.00.50.1-0.10.3-0.1-0.1-0.00.1-0.1
Food seeking constrained by brief footshock4.65.89.9-2.52.5-3.12.6-2.6-2.22.2-1.62.02.21.72.7-2.7
Seeking ratio, punishment vs. effort0.30.72.0-0.90.9-1.40.8-1.2-0.80.7-0.80.70.80.50.7-0.7
Retroperitoneal fat weight22.6101.0131.910.6-10.611.5-10.310.410.0-10.09.9-9.7-9.6-8.6-9.69.5
Reaction time number correct0.20.70.9-0.90.9-0.60.8-0.8-0.90.9-1.01.00.90.90.6-0.6
Reaction time mean minus median0.00.10.3-0.10.1-0.40.2-0.50.0-0.00.2-0.2-0.0-0.20.3-0.3
Reaction time mean minus median AUC0.00.10.10.2-0.20.2-0.2-0.10.3-0.30.2-0.3-0.3-0.3-0.10.1
Reaction time num false alarms0.30.64.20.6-0.62.1-0.60.80.2-0.1-0.6-0.1-0.10.5-0.80.8
Reaction time num false alarms AUC0.30.64.40.5-0.52.1-0.60.80.1-0.1-0.7-0.0-0.10.5-0.90.9
Reaction time trials correct on left0.20.70.9-0.90.9-0.60.8-0.8-0.90.9-1.01.00.90.90.6-0.6
Reaction time trials on left0.20.71.0-0.90.9-0.60.8-0.9-0.91.0-1.01.00.90.90.6-0.6
Reaction time mean0.71.62.51.1-1.10.3-1.21.11.3-1.31.3-1.4-1.4-1.6-1.41.4
Reaction time mean AUC0.61.42.11.0-1.00.2-1.11.01.2-1.21.1-1.3-1.3-1.4-1.31.4
Median of all reaction times1.21.92.81.2-1.20.4-1.41.41.4-1.41.3-1.4-1.5-1.6-1.61.7
Reaction time omissions0.00.10.4-0.10.10.60.10.0-0.20.2-0.10.20.30.50.1-0.0
Reaction time false alarm rate0.71.04.80.9-0.92.2-0.91.10.6-0.5-0.2-0.5-0.60.0-1.11.2
Reaction time premature initiation rate0.10.10.30.4-0.40.2-0.30.10.5-0.50.3-0.6-0.4-0.5-0.20.2
Reaction time premature initiations0.00.00.1-0.00.1-0.10.1-0.4-0.00.0-0.3-0.00.00.00.1-0.1
Std. dev. reaction times0.10.40.60.6-0.60.2-0.60.50.7-0.70.8-0.8-0.7-0.8-0.60.6
Reaction time trials completed0.20.71.0-0.90.9-0.60.8-0.9-0.91.0-1.01.00.90.90.6-0.6
Reaction time trials AUC0.30.91.2-1.01.0-0.70.9-1.0-1.11.1-1.11.11.01.00.7-0.7
Run reversals in cocaine runway, females0.10.10.9-0.00.0-0.9-0.00.00.2-0.2-0.0-0.3-0.3-0.5-0.10.1
Run reversals in cocaine runway, males0.20.20.8-0.30.3-0.90.5-0.7-0.20.2-0.40.10.1-0.00.5-0.5
Latency to leave start box in cocaine runway0.60.81.5-1.01.0-1.20.9-0.4-0.80.8-0.41.00.90.61.0-1.1
Latency to leave start box in cocaine runway, F0.20.20.4-0.50.5-0.50.5-0.1-0.50.5-0.60.60.50.50.5-0.5
Latency to leave start box in cocaine runway, M0.40.41.7-0.60.6-1.30.6-0.5-0.30.30.50.50.3-0.10.8-0.8
Std. dev. time between licks in bursts0.30.52.50.6-0.61.6-0.80.90.3-0.30.2-0.1-0.30.0-0.90.9
Total sessions with >9 infusions1.21.53.1-1.11.1-1.61.5-1.4-0.90.9-0.40.70.90.71.7-1.8
Short access day 1 total inactive lever presses4.28.39.9-3.03.0-2.32.9-3.0-3.13.1-2.63.03.03.12.5-2.3
Short access day 10 total inactive lever presses0.53.74.8-2.02.0-1.32.0-2.2-2.12.1-2.01.92.02.11.7-1.6
Short access day 1 total infusions2.85.58.4-2.32.3-2.32.7-2.4-2.22.2-1.32.12.32.12.9-2.9
Short access day 10 total infusions1.83.05.4-1.81.8-2.32.0-1.6-1.61.6-1.51.31.51.31.9-1.8
Short access total infusions1.31.93.4-1.31.4-1.71.6-1.3-1.21.2-0.61.01.21.01.8-1.9
Short access day 1 locomotion2.64.36.8-2.02.0-2.12.3-2.6-1.81.8-1.31.71.91.62.6-2.6
Short access day 10 total locomotion0.52.24.2-1.51.5-1.51.6-2.0-1.41.4-1.31.21.31.31.4-1.4
Short access total locomotion0.30.51.1-0.60.6-1.10.9-1.0-0.40.4-0.10.10.40.21.0-0.9
One hour access (0.3 mA shock)1.41.73.3-1.41.4-1.81.4-1.5-1.21.2-0.71.11.10.81.3-1.3
Compulsive drug intake1.21.84.31.3-1.32.1-1.51.51.0-1.00.4-0.9-1.0-0.7-1.81.8
One hour access (shock baseline)1.33.47.4-1.91.9-2.72.0-2.1-1.61.6-1.21.51.51.12.1-2.1
Social response proportion0.20.30.60.4-0.4-0.1-0.40.80.5-0.50.8-0.6-0.6-0.7-0.40.4
Social responses0.10.20.50.4-0.40.7-0.50.60.3-0.30.3-0.2-0.3-0.2-0.50.5
Social time0.20.41.50.5-0.50.3-0.50.40.6-0.61.2-0.5-0.6-0.7-0.40.3
Soleus weight4.212.416.4-3.73.7-3.33.5-3.3-3.73.7-4.13.63.53.53.1-3.1
Bone: stiffness0.00.00.1-0.10.10.3-0.0-0.3-0.10.2-0.10.30.10.2-0.10.0
Tibialis anterior weight3.211.214.7-3.43.4-2.43.3-3.3-3.53.5-3.83.53.43.63.0-3.0
Time to tail flick, vehicle, before self-admin0.60.81.60.9-0.90.4-0.60.21.1-1.11.2-1.3-1.0-1.2-0.30.3
Time to tail flick, vehicle, after self-admin2.14.35.62.2-2.21.7-1.91.92.3-2.32.2-2.4-2.2-2.2-1.61.6
Time to tail flick, test, before self-admin0.10.10.2-0.20.2-0.20.4-0.5-0.20.2-0.40.10.20.20.5-0.4
Time to tail flick, test, after self-admin0.20.20.9-0.50.5-0.90.5-0.4-0.30.3-0.40.30.20.00.4-0.3
Delta time to tail flick, vehicle, before/after SA0.20.20.80.4-0.40.7-0.40.90.3-0.30.2-0.2-0.3-0.1-0.30.3
Delta time to tail flick, test, before/after SA1.21.42.0-1.41.4-1.41.2-1.0-1.31.3-1.31.31.11.10.9-0.9
Tibia length2.77.48.62.7-2.72.3-2.82.92.7-2.72.9-2.6-2.7-2.6-2.82.8
Ambulatory time before self-admin0.00.10.6-0.20.2-0.7-0.0-0.1-0.10.1-0.10.00.0-0.2-0.20.2
Ambulatory time after self-admin1.01.62.41.1-1.10.7-1.41.41.2-1.21.3-1.0-1.1-1.3-1.61.5
Bone: tissue strength0.70.81.10.9-0.90.5-0.90.71.0-1.00.6-1.0-1.0-1.1-0.90.9
Total heroin consumption2.73.15.2-1.81.8-1.41.7-1.8-1.81.8-2.31.81.81.91.5-1.5
Bone: trabecular number2.54.86.4-2.32.3-1.82.0-1.4-2.42.5-2.52.52.42.51.6-1.6
Bone: trabecular spacing2.33.34.81.9-1.91.1-1.81.22.1-2.11.8-2.1-2.0-2.2-1.51.6
Bone: trabecular thickness0.50.71.3-0.90.9-0.30.70.0-1.01.0-0.91.11.01.10.5-0.5
Bone: trabecular tissue density0.30.50.8-0.80.8-0.90.6-0.9-0.70.7-0.60.80.70.60.6-0.5
Water consumed over 24 hours0.20.40.9-0.50.50.20.3-0.2-0.70.8-0.90.80.71.00.0-0.0
Number of responses in last shaping day0.30.41.3-0.60.6-0.90.7-0.5-0.40.40.40.40.50.31.1-1.2