Hub : Genes

Eif2b4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Eye mRNA stability Eif2b4 0.3 0.18 2.0e-03 0.1 0.06 0.04 0.08 1.2e-02 4.0e-02 9.2e-02 2.4e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1
Bone: apparent density5.28.68.6-2.9
Area under the delay curve0.70.80.8-0.9
BMI with tail0.30.90.90.9
BMI without tail0.20.50.50.7
Body weight1.77.17.12.7
Weight adjusted by age0.00.00.0-0.1
Bone surface2.44.14.1-2.0
Bone volume2.44.14.1-2.0
Breakpoint value in progressive ratio session1.51.61.6-1.3
Number of licking bursts0.30.30.3-0.5
Context. condit. distance diff. score0.00.00.00.1
Locomotion velocity, session 10.20.20.20.4
Locomotion distance, session 11.82.32.3-1.5
Locomotion velocity, session 20.10.10.10.4
Locomotion distance, session 20.00.00.00.1
Locomotion velocity, session 30.40.40.4-0.7
Locomotion distance, session 30.80.90.9-0.9
Stereotopy head waving bouts, day 31.72.02.0-1.4
Stereotopy head waving duration, day 30.10.10.1-0.3
Locomotion velocity, session 70.60.60.6-0.8
Locomotion distance, session 70.00.00.00.0
Stereotopy head waving bouts, day 70.00.00.00.0
Stereotopy head waving duration, day 70.30.40.4-0.6
Locomotion velocity, session 80.00.00.0-0.0
Locomotion distance, session 80.20.30.3-0.6
Degree of sensitization distance1.01.01.01.0
Degree of sensitization stereotypy0.10.10.10.3
Conditioned locomotion3.74.34.3-2.1
Cocaine response after cond. corrected1.31.51.5-1.2
Cocaine response after cond. not corrected2.73.03.0-1.7
Cocaine response before conditioning1.01.21.2-1.1
Saline control response0.40.50.5-0.7
Bone: connectivity density5.38.38.3-2.9
Bone: cortical apparent density0.40.50.5-0.7
Bone: cortical area0.20.40.4-0.6
Bone: cortical porosity1.01.11.1-1.0
Bone: cortical porosity0.80.90.9-0.9
Bone: cortical thickness0.00.00.00.2
Bone: cortical thickness1.61.91.9-1.4
Bone: cortical tissue density0.30.40.4-0.6
Condit. Reinf. active minus inactive responses0.30.30.30.6
Condit. Reinf. active-inactive response ratio0.30.40.40.6
Condit. Reinf. active responses0.50.60.6-0.8
Condit. Reinf. inactive responses2.12.42.4-1.6
Incentive salience index mean0.10.20.2-0.4
Condit. Reinf. lever presses1.01.41.4-1.2
Condit. Reinf. active minus inactive responses4.15.05.0-2.2
Condit. Reinf. active-inactive response ratio1.01.11.1-1.0
Condit. Reinf. active responses3.44.74.7-2.2
Condit. Reinf. inactive responses2.12.52.5-1.6
Condit. Reinf. lever presses2.53.43.4-1.8
Condit. Reinf. lever reinforcers received2.84.04.0-2.0
Conditioned reinforcement - actives0.10.10.1-0.3
Conditioned reinforcement - inactives1.61.81.8-1.3
Conditioned locomotion0.40.50.50.7
Patch foraging indifference point 0 sec0.40.60.60.8
Patch foraging indifference point AUC1.82.12.1-1.4
Delay disc. indifference point, 0s delay1.21.41.41.2
Delay disc. indifference point, 16s delay1.31.31.3-1.2
Delay disc. indifference point, 2s delay0.10.10.10.4
Delay disc. indifference point, 24s delay5.65.45.4-2.3
Delay disc. indifference point, 4s delay0.00.00.0-0.1
Delay disc. indifference point, 8s delay0.90.90.9-1.0
Indifference point function ln k0.00.10.10.3
Indifference point function log k0.00.10.10.3
Patch foraging total patch changes 0 sec0.20.40.40.6
Patch foraging total patch changes 12 sec0.81.01.01.0
Patch foraging total patch changes 18 sec0.00.00.00.2
Patch foraging total patch changes 24 sec1.21.51.51.2
Patch foraging total patch changes 6 sec0.00.00.00.1
Patch foraging time to switch 0 sec0.10.10.1-0.3
Patch foraging water rate 0 sec0.00.10.10.3
Patch foraging water rate 12 sec1.62.42.41.6
Patch foraging water rate 18 sec0.71.01.01.0
Patch foraging water rate 24 sec1.72.42.41.6
Patch foraging water rate 6 sec1.52.12.11.5
Seeking ratio, delayed vs. immediate footshock0.40.50.50.7
Distance traveled before self-admin0.10.10.1-0.3
Distance traveled after self-admin0.30.40.40.6
Extensor digitorum longus weight4.718.518.5-4.3
Bone: elastic displacement1.01.21.2-1.1
Bone: elastic work1.41.81.8-1.3
Bone: endosteal estimation0.30.70.7-0.8
Bone: endosteal perimeter0.10.30.3-0.5
Epididymis fat weight15.034.934.95.9
Delta time in closed arm before/after self-admin0.00.00.00.1
Delta time in open arm before/after self-admin0.30.30.3-0.5
Diff in mean of infusions in LGA sessions0.10.10.1-0.3
Delay discount exponential model param1.31.41.41.2
Extinction: sum of active levers before priming0.80.80.8-0.9
Active lever presses in extinction session 60.10.10.1-0.2
Bone: final force0.00.00.0-0.2
Bone: final moment0.00.10.1-0.3
Food consumed during 24 hour testing period0.20.30.3-0.5
Glucose0.30.50.50.7
Heart weight11.716.616.64.1
Delay discount hyperbolic model param1.01.11.11.0
Intermittent access intake day 1-15 change0.00.00.00.1
Intermittent access intake escalation0.10.10.10.4
Intermittent access intake escalation 20.80.80.80.9
Intermitt. access day 1 inactive lever presses0.00.00.0-0.0
Intermitt. access day 15 inactive lever presses4.54.94.9-2.2
Intermitt. access escalation Index0.50.40.40.6
Intermittent access day 1 total infusions4.24.94.9-2.2
Intermittent access day 15 total infusions1.21.31.3-1.1
Intermittent access terminal intake (last 3 days)0.91.01.0-1.0
Intermittent access total infusions1.31.41.4-1.2
Intermittent access day 1 locomotion1.92.02.0-1.4
Intermittent access day 15 total locomotion0.20.20.2-0.5
Intermittent access total locomotion0.00.00.0-0.2
Intermittent access standard deviation0.00.00.00.0
Left kidney weight0.00.00.00.0
Right kidney weight0.82.22.21.5
Cocaine induced anxiety0.10.10.1-0.2
Post-drug Anxiety0.70.70.70.9
Baseline Anxiety0.60.70.70.8
Tail length0.10.40.40.7
Length with tail1.55.45.42.3
Length without tail0.61.41.41.2
Times rat made contact with spout2.73.13.1-1.8
Lifetime Intake1.82.02.0-1.4
Liver weight, left1.21.91.91.4
Liver weight, right8.814.614.63.8
Locomotor activity0.00.00.00.1
Locomotor testing distance0.30.50.5-0.7
Locomotor testing rearing0.50.80.8-0.9
Locomotion in novel chamber1.11.41.41.2
Locomotion in novel chamber post-restriction1.31.61.61.3
Fecal boli incidents, locomotor time 10.20.20.2-0.4
Change in fecal boli incidents, locomotor task3.73.53.51.9
Time >=10cm from walls, locomotor time 10.00.00.0-0.2
Bouts of movement, locomotor time 12.83.03.0-1.7
Total resting periods, locomotor time 12.73.03.0-1.7
Rest time, locomotor task time 10.00.00.0-0.0
Distance moved, locomotor task time 10.60.60.60.8
Vertical activity count, locomotor time 10.10.10.10.3
Time >=10cm from walls, locomotor time 20.00.00.0-0.0
Bouts of movement, locomotor time 20.10.10.10.3
Total resting periods, locomotor time 20.00.00.00.1
Rest time, locomotor task time 21.82.02.0-1.4
Distance moved, locomotor task time 21.01.11.11.1
Vertical activity count, locomotor time 20.70.80.80.9
Light reinforcement 14.48.18.1-2.8
Light reinforcement 23.64.84.8-2.2
Bone: marrow area0.40.80.8-0.9
Bone: maximum diameter0.81.51.5-1.2
Bone: maximum force0.00.00.00.1
Bone: maximum moment0.00.00.0-0.1
Mean time between licks in bursts2.33.33.31.8
Mean num. licks in bursts0.10.10.1-0.3
Cd content in liver0.00.00.0-0.0
Co content in liver5.76.76.7-2.6
Cu content in liver0.00.00.0-0.2
Fe content in liver0.10.10.10.3
K content in liver0.10.10.10.2
Mg content in liver0.20.20.20.4
Mn content in liver0.50.50.5-0.7
Na content in liver0.20.20.2-0.5
Rb content in liver0.00.00.00.1
Se content in liver0.60.70.70.9
Sr content in liver0.00.00.00.1
Zn content in liver1.31.51.51.2
Bone: minimum diameter0.10.30.30.5
Time in familiar zone, hab. session 11.00.90.91.0
Time in novel zone, hab. session 10.60.60.60.8
Total zone transitions, hab. session 10.10.20.2-0.4
Total locomotion distance, hab. session 10.10.10.1-0.3
Locomotion velocity, hab. session 11.01.41.4-1.2
Time in familiar zone, hab. session 20.00.00.00.1
Time in novel zone, hab. session 20.30.30.30.5
Total zone transitions, hab. session 20.20.20.2-0.5
Total locomotion distance, hab. session 20.20.30.3-0.5
Locomotion velocity, hab. session 20.50.60.6-0.8
Novel to familiar place preference ratio0.50.50.50.7
Novelty place preference1.01.01.01.0
Time in novel zone, NPP test1.21.31.31.1
Total zone transitions, NPP test1.21.81.8-1.3
Total locomotion distance, NPP test1.62.32.3-1.5
Locomotion velocity, NPP test3.14.44.4-2.1
Intraocular pressure3.34.54.52.1
Delta distance traveled before/after self-admin1.61.81.81.3
Delta ambulatory time before/after self-admin0.30.40.40.6
Parametrial fat weight5.410.510.53.2
Pavlov. Cond. lever latency1.72.12.11.5
Pavlov. Cond. magazine entry latency0.00.00.0-0.1
Pavlov. Cond. change in total contacts0.10.10.1-0.2
Pavlov. Cond. index score0.70.90.9-1.0
Pavlov. Cond. latency score0.70.80.8-0.9
Pavlov. Cond. lever contacts1.21.41.4-1.2
Pavlov. Cond. magazine entry number0.40.50.50.7
Pavlov. Cond. intertrial magazine entries1.41.81.8-1.3
Pavlov. Cond. lever-magazine prob. diff.1.72.22.2-1.5
Pavlov. Cond. response bias1.51.91.9-1.4
Pavlov. Cond. lever latency1.82.52.51.6
Pavlov. Cond. magazine entry latency0.10.10.1-0.4
Pavlov. Cond. change in total contacts0.81.01.0-1.0
Pavlov. Cond. index score0.91.21.2-1.1
Pavlov. Cond. latency score0.91.11.1-1.0
Pavlov. Cond. lever contacts1.11.51.5-1.2
Pavlov. Cond. magazine entry number0.10.10.10.3
Pavlov. Cond. intertrial magazine entries3.34.34.32.1
Pavlov. Cond. lever-magazine prob. diff.0.60.80.8-0.9
Pavlov. Cond. response bias1.92.62.6-1.6
Time in closed arm before self-admin0.60.70.70.9
Time in closed arm after self-admin1.51.51.51.2
Time in open arm before self-admin0.20.30.3-0.5
Time in open arm after self-admin2.42.72.7-1.6
Bone: periosteal estimation0.51.11.1-1.0
Bone: periosteal perimeter0.20.40.4-0.6
Bone: post-yield work0.30.30.3-0.6
Progressive ratio test 1 active lever presses0.40.40.4-0.6
Progressive ratio test 1 breakpoint0.30.30.3-0.6
Progressive ratio test 1 inactive lever presses1.21.31.3-1.1
Progressive ratio test 2 active lever presses0.10.10.10.3
Progressive ratio test 2 breakpoint0.00.10.10.2
Progressive ratio test 2 inactive lever presses0.50.60.6-0.8
Incentive Sensitization - Responses0.20.20.20.5
Incentive Sensitization - Breakpoint0.50.60.60.7
Sum of active levers in priming session hrs 5-61.51.41.4-1.2
Progressive ratio0.10.10.10.3
Food seeking constrained by brief footshock2.42.92.9-1.7
Seeking ratio, punishment vs. effort1.01.21.2-1.1
Retroperitoneal fat weight22.072.372.38.5
Reaction time number correct0.60.90.9-1.0
Reaction time mean minus median0.00.00.00.1
Reaction time mean minus median AUC0.00.10.10.2
Reaction time num false alarms0.30.50.5-0.7
Reaction time num false alarms AUC0.50.60.6-0.8
Reaction time trials correct on left0.60.90.9-1.0
Reaction time trials on left0.71.01.0-1.0
Reaction time mean1.11.51.51.2
Reaction time mean AUC0.91.21.21.1
Median of all reaction times1.11.51.51.2
Reaction time omissions0.00.10.1-0.2
Reaction time false alarm rate0.00.00.0-0.2
Reaction time premature initiation rate0.10.20.20.4
Reaction time premature initiations0.00.00.0-0.2
Std. dev. reaction times0.40.60.60.7
Reaction time trials completed0.71.01.0-1.0
Reaction time trials AUC0.91.31.3-1.1
Run reversals in cocaine runway, females0.10.10.1-0.3
Run reversals in cocaine runway, males0.90.90.9-1.0
Latency to leave start box in cocaine runway0.20.20.2-0.5
Latency to leave start box in cocaine runway, F0.50.60.6-0.8
Latency to leave start box in cocaine runway, M0.00.00.0-0.2
Std. dev. time between licks in bursts0.10.20.20.4
Total sessions with >9 infusions1.01.11.1-1.0
Short access day 1 total inactive lever presses3.84.34.3-2.1
Short access day 10 total inactive lever presses0.91.01.0-1.0
Short access day 1 total infusions2.42.62.6-1.6
Short access day 10 total infusions2.83.13.1-1.8
Short access total infusions1.41.61.6-1.3
Short access day 1 locomotion4.04.34.3-2.1
Short access day 10 total locomotion0.20.30.3-0.5
Short access total locomotion0.10.10.1-0.3
One hour access (0.3 mA shock)1.31.51.5-1.2
Compulsive drug intake0.00.00.0-0.0
One hour access (shock baseline)0.60.70.7-0.9
Social response proportion0.60.60.60.8
Social responses0.30.30.30.6
Social time1.41.91.91.4
Soleus weight5.215.215.2-3.9
Bone: stiffness0.10.10.10.3
Tibialis anterior weight3.812.912.9-3.6
Time to tail flick, vehicle, before self-admin2.72.72.71.7
Time to tail flick, vehicle, after self-admin4.95.35.32.3
Time to tail flick, test, before self-admin0.40.40.4-0.6
Time to tail flick, test, after self-admin0.10.10.10.4
Delta time to tail flick, vehicle, before/after SA0.10.10.10.3
Delta time to tail flick, test, before/after SA0.30.30.3-0.5
Tibia length2.87.97.92.8
Ambulatory time before self-admin0.30.30.3-0.5
Ambulatory time after self-admin0.20.30.30.5
Bone: tissue strength0.60.60.60.8
Total heroin consumption3.23.73.7-1.9
Bone: trabecular number4.26.56.5-2.6
Bone: trabecular spacing2.63.43.41.8
Bone: trabecular thickness0.50.60.6-0.8
Bone: trabecular tissue density0.10.10.1-0.3
Water consumed over 24 hours1.82.22.2-1.5
Number of responses in last shaping day0.20.20.2-0.5