Dzank1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Dzank1	0.06	0.04	1.7e-05	0.05	0.03	0.04	0.03	1.4e-05	4.1e-04	1.2e-04	1.8e-03
2	Adipose	gene expression	Dzank1	0.1	0.06	6.4e-07	0.04	0.05	0.02	0.04	3.6e-05	6.1e-06	1.1e-03	2.8e-05
3	pVTA	intron excision ratio	chr3_152359881_152360383	0.06	0.04	1.8e-05	0.05	0.05	0.05	0.05	8.9e-05	1.2e-04	4.8e-05	9.3e-05
4	pVTA	intron excision ratio	chr3_152359881_152361415	0.05	0.03	1.5e-04	0.05	0.04	0.04	0.04	1.2e-04	2.5e-04	2.6e-04	3.5e-04
5	Adipose	mRNA stability	Dzank1	0.02	0.02	9.7e-03	0	-0	-0	0	2.8e-01	6.4e-01	8.3e-01	2.5e-01
6	PL	intron excision ratio	chr3_152359881_152360383	0.1	0.06	6.2e-09	0.07	0.06	0.09	0.09	1.3e-08	9.8e-07	1.1e-09	1.4e-09
7	PL	mRNA stability	Dzank1	0.03	0.02	3.9e-04	0.05	0.02	0.03	0.04	2.6e-06	1.6e-03	3.5e-04	7.4e-05
8	pVTA	gene expression	Dzank1	0.15	0.08	4.4e-06	0.02	0.06	0.06	0.05	1.5e-02	1.4e-05	1.7e-05	7.1e-05
9	PL	intron excision ratio	chr3_152359881_152361415	0.03	0.03	1.4e-03	0.01	0.02	0.03	0.03	2.7e-02	1.0e-03	8.6e-04	7.9e-04
10	Brain	mRNA stability	Dzank1	0.05	0.03	1.1e-04	0.01	0.02	0	0.01	2.0e-02	3.7e-03	1.2e-01	3.0e-02
11	Brain	intron excision ratio	chr3_152357478_152359765	0.21	0.16	2.7e-03	0.02	0.01	0.03	0.01	5.1e-03	1.7e-02	9.5e-04	2.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9	10	11
Bone: apparent density	0.1	0.2	0.9	0.4	0.6	0.5	-0.5	-0.1	0.3	-1.0	0.1	0.3	0.1	-0.1
Area under the delay curve	1.6	1.9	5.0	1.4	2.0	0.5	-0.4	-0.3	-0.5	-0.6	2.2	1.9	1.8	1.3
BMI with tail	6.2	21.5	38.6	-6.2	-5.3	-6.0	5.8	5.7	-5.3	4.4	-1.9	2.1	1.1	3.3
BMI without tail	5.2	15.7	27.3	-5.2	-4.6	-5.1	4.8	4.8	-4.5	3.6	-1.9	2.2	0.7	2.9
Body weight	6.3	27.7	60.7	-7.8	-6.9	-6.6	6.5	6.4	-5.4	4.1	-3.2	1.5	-0.2	3.1
Weight adjusted by age	0.4	0.5	1.8	0.4	0.2	0.8	-0.8	-0.7	0.8	-1.4	-0.4	-0.6	-0.9	-0.4
Bone surface	0.2	0.4	1.0	-0.7	-1.0	-0.7	0.3	0.7	-0.3	0.6	-0.7	-0.1	-0.2	-0.7
Bone volume	0.1	0.2	0.6	-0.3	-0.4	-0.0	-0.4	0.2	0.2	-0.3	-0.6	-0.3	-0.5	-0.8
Breakpoint value in progressive ratio session	0.6	0.7	2.5	-0.6	-1.0	-1.0	0.8	0.6	-0.5	1.6	-1.0	0.0	-0.2	-0.3
Number of licking bursts	0.2	0.3	0.8	-0.1	0.6	-0.1	-0.0	0.4	-0.3	-0.3	0.4	0.8	0.6	0.9
Context. condit. distance diff. score	0.1	0.1	0.5	-0.2	-0.1	-0.0	0.2	0.0	0.2	-0.4	-0.7	-0.3	-0.4	0.2
Locomotion velocity, session 1	1.7	1.8	9.9	1.3	-0.0	0.8	-1.6	-1.4	1.1	0.6	-0.4	-0.7	-0.9	-3.2
Locomotion distance, session 1	2.9	3.6	6.9	2.5	1.9	2.2	-2.6	-2.2	1.8	-1.3	1.2	-0.7	-0.3	-2.5
Locomotion velocity, session 2	1.6	1.9	6.1	1.8	1.4	1.0	-1.6	-1.2	0.5	-0.0	1.8	0.6	0.9	-2.5
Locomotion distance, session 2	4.4	6.1	12.2	2.7	1.7	2.8	-3.5	-3.0	2.8	-1.9	-0.1	-1.7	-1.5	-3.3
Locomotion velocity, session 3	2.0	2.2	4.6	2.1	1.9	1.8	-2.0	-1.7	1.5	-1.1	0.9	-0.2	0.0	-1.3
Locomotion distance, session 3	0.7	0.8	2.1	1.3	1.4	1.0	-1.1	-0.8	0.7	-0.6	0.9	0.3	0.5	-0.5
Stereotopy head waving bouts, day 3	0.2	0.3	1.0	-0.2	-0.5	-0.1	-0.6	-0.2	0.2	0.5	-0.4	-0.6	-0.5	-1.0
Stereotopy head waving duration, day 3	0.2	0.2	0.6	-0.4	-0.8	-0.3	-0.1	0.0	0.0	0.7	-0.6	-0.5	-0.5	-0.6
Locomotion velocity, session 7	1.4	1.5	4.7	1.0	0.6	1.4	-1.4	-1.3	1.1	-1.4	0.3	-0.9	-0.9	-2.2
Locomotion distance, session 7	0.7	0.9	3.2	0.1	-0.3	0.7	-0.8	-0.7	0.8	-1.0	-0.3	-1.2	-1.2	-1.8
Stereotopy head waving bouts, day 7	0.1	0.1	0.4	-0.3	-0.1	-0.4	-0.1	0.5	-0.4	0.3	0.3	0.6	0.4	-0.3
Stereotopy head waving duration, day 7	0.1	0.1	0.3	0.5	0.5	0.2	-0.5	-0.2	0.1	0.0	0.2	0.5	0.3	-0.4
Locomotion velocity, session 8	1.2	1.4	5.8	1.0	-0.0	0.9	-1.4	-1.4	1.2	-0.2	-0.5	-1.2	-1.1	-2.4
Locomotion distance, session 8	2.1	3.1	5.7	1.8	1.1	2.0	-2.4	-2.1	2.0	-1.8	-0.1	-1.6	-1.3	-2.0
Degree of sensitization distance	1.0	1.0	2.5	-1.1	-1.6	-0.3	0.3	0.2	-0.0	-0.3	-1.0	-1.3	-1.5	-1.4
Degree of sensitization stereotypy	0.2	0.2	0.6	-0.5	-0.3	-0.6	0.2	0.7	-0.5	0.4	-0.2	0.8	0.3	-0.0
Conditioned locomotion	0.6	0.7	1.8	0.3	-0.6	0.4	-0.3	-0.7	0.9	-0.1	-1.3	-1.1	-1.3	-1.0
Cocaine response after cond. corrected	1.7	2.1	4.2	1.0	0.9	1.8	-2.0	-1.5	1.6	-2.0	0.1	-1.4	-1.2	-1.2
Cocaine response after cond. not corrected	2.8	3.3	7.3	1.5	1.4	2.3	-2.5	-2.0	2.0	-2.7	0.2	-1.5	-1.3	-1.1
Cocaine response before conditioning	0.2	0.2	0.5	0.6	0.7	0.4	-0.2	-0.4	0.2	-0.6	0.4	0.2	0.1	0.4
Saline control response	1.9	2.6	7.1	-1.1	-2.1	-0.1	-0.4	-0.4	0.8	-0.2	-2.6	-2.3	-2.7	-1.5
Bone: connectivity density	0.1	0.2	0.5	0.7	0.6	0.5	-0.0	-0.3	0.3	-0.4	0.4	0.2	0.4	0.0
Bone: cortical apparent density	0.5	0.6	1.7	0.7	0.9	0.2	0.7	-0.1	-0.3	-0.0	1.2	0.7	1.2	1.3
Bone: cortical area	0.3	0.4	1.2	-0.5	-0.4	-0.6	0.9	0.7	-1.1	0.5	0.6	0.5	0.7	0.6
Bone: cortical porosity	0.4	0.5	1.7	-0.5	-0.4	-0.7	0.7	0.6	-0.9	1.3	0.0	0.5	0.6	0.7
Bone: cortical porosity	0.6	0.6	1.7	-0.8	-0.8	-0.9	0.9	0.7	-1.0	1.3	-0.2	0.4	0.4	0.9
Bone: cortical thickness	1.1	1.8	3.9	0.0	0.3	-0.8	1.6	0.9	-1.6	1.2	1.5	1.7	2.0	1.7
Bone: cortical thickness	0.8	0.9	2.9	1.2	1.4	0.9	-0.3	-0.5	-0.0	-0.8	1.7	0.7	1.1	0.4
Bone: cortical tissue density	0.3	0.5	1.3	0.6	0.8	0.3	0.6	-0.1	-0.2	-0.1	1.0	0.5	1.0	1.1
Condit. Reinf. active minus inactive responses	0.1	0.1	0.5	0.0	0.5	0.3	-0.3	-0.1	0.3	-0.7	-0.3	0.2	-0.2	0.6
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.8	0.2	0.6	0.5	-0.3	-0.1	0.3	-0.9	-0.2	0.2	-0.2	0.8
Condit. Reinf. active responses	0.1	0.1	0.4	0.2	0.6	0.4	-0.4	-0.2	0.4	-0.6	-0.0	0.3	-0.1	0.1
Condit. Reinf. inactive responses	0.2	0.2	1.6	-0.1	-0.4	-0.1	-0.0	-0.1	0.0	0.5	0.1	-0.2	-0.2	-1.2
Incentive salience index mean	0.5	0.7	2.1	0.7	1.4	0.6	-0.4	-0.1	-0.0	-0.7	1.1	1.1	0.9	0.6
Condit. Reinf. lever presses	1.3	1.8	5.2	0.6	1.7	0.2	0.0	0.5	-0.9	-0.4	2.3	2.0	2.1	1.0
Condit. Reinf. active minus inactive responses	1.1	1.4	4.0	-1.5	-2.0	-1.2	1.2	0.7	-0.8	1.2	-1.5	-0.5	-1.0	-0.4
Condit. Reinf. active-inactive response ratio	0.7	0.8	2.0	-1.2	-1.4	-1.1	0.8	0.8	-0.7	1.0	-1.3	0.0	-0.6	-0.0
Condit. Reinf. active responses	0.9	1.2	2.8	-1.1	-1.3	-1.3	1.7	1.0	-1.4	1.5	-0.4	0.5	0.3	0.5
Condit. Reinf. inactive responses	0.7	0.9	2.1	-0.2	0.0	-0.7	1.2	0.7	-1.2	1.1	1.1	1.1	1.4	0.8
Condit. Reinf. lever presses	2.1	2.9	5.8	-2.2	-2.4	-2.2	2.0	1.8	-1.4	1.8	-1.9	0.3	-0.6	0.4
Condit. Reinf. lever reinforcers received	1.0	1.4	3.1	-1.3	-1.5	-1.5	1.7	1.1	-1.4	1.7	-0.7	0.4	0.2	0.4
Conditioned reinforcement - actives	1.8	3.1	7.4	0.5	-0.5	1.2	-1.5	-1.8	2.1	-0.8	-1.5	-2.7	-2.5	-2.3
Conditioned reinforcement - inactives	2.6	3.8	10.4	0.7	-0.4	1.6	-1.3	-2.2	2.5	-1.4	-1.8	-3.2	-2.8	-1.5
Conditioned locomotion	0.2	0.2	0.9	1.0	0.7	0.5	-0.2	-0.8	0.6	-0.1	0.0	-0.0	0.0	-0.2
Patch foraging indifference point 0 sec	1.4	2.6	6.3	0.1	-0.7	1.2	-0.9	-1.1	1.9	-1.7	-1.7	-2.4	-2.5	-1.7
Patch foraging indifference point AUC	0.5	0.7	2.0	1.3	1.4	0.6	-0.7	-0.8	0.4	-0.0	1.0	0.8	1.0	0.0
Delay disc. indifference point, 0s delay	1.6	1.8	4.0	-0.1	0.5	-1.1	1.0	1.0	-1.6	1.2	1.5	2.0	1.9	1.6
Delay disc. indifference point, 16s delay	1.3	1.4	4.0	1.6	2.0	1.0	-1.0	-0.7	0.4	-0.8	1.7	1.0	1.1	0.7
Delay disc. indifference point, 2s delay	1.3	1.4	4.5	-0.2	0.5	-0.8	0.7	1.2	-1.5	0.2	1.3	2.1	1.6	1.3
Delay disc. indifference point, 24s delay	2.9	3.2	8.0	2.5	2.8	1.9	-1.8	-1.8	1.0	-1.9	2.4	0.4	0.9	0.3
Delay disc. indifference point, 4s delay	1.2	1.2	3.9	-0.0	0.7	-0.5	0.4	0.8	-1.3	-0.2	1.7	2.0	1.6	1.1
Delay disc. indifference point, 8s delay	0.9	1.1	2.9	1.7	1.7	0.7	-0.7	-0.9	0.1	-0.4	1.3	1.0	1.0	0.4
Indifference point function ln k	0.3	0.6	1.9	-0.1	-0.8	0.4	-0.1	-0.5	0.5	-0.5	-0.7	-1.3	-1.4	-0.8
Indifference point function log k	0.3	0.6	1.9	-0.1	-0.8	0.4	-0.1	-0.5	0.5	-0.5	-0.7	-1.3	-1.4	-0.8
Patch foraging total patch changes 0 sec	1.4	2.6	5.8	0.4	-0.4	1.3	-1.2	-1.3	2.1	-1.7	-1.7	-2.2	-2.4	-1.8
Patch foraging total patch changes 12 sec	0.1	0.1	0.5	-0.2	-0.5	-0.2	0.1	0.1	-0.0	-0.4	-0.0	0.1	-0.2	-0.7
Patch foraging total patch changes 18 sec	1.1	1.7	3.4	1.1	0.7	1.5	-1.3	-1.6	1.9	-1.6	-0.5	-1.5	-1.2	-0.7
Patch foraging total patch changes 24 sec	0.2	0.3	0.7	0.3	0.2	0.6	-0.6	-0.4	0.8	-0.7	-0.4	-0.4	-0.5	-0.2
Patch foraging total patch changes 6 sec	0.6	0.9	3.1	0.3	0.3	1.0	-0.8	-0.6	1.3	-1.8	-0.6	-0.9	-1.1	-0.6
Patch foraging time to switch 0 sec	1.0	2.0	3.6	-1.9	-1.3	-1.7	1.6	1.9	-1.8	1.2	0.2	0.9	0.9	1.4
Patch foraging water rate 0 sec	1.1	2.3	4.3	2.1	1.8	1.9	-1.5	-1.9	1.9	-1.7	0.3	-0.5	-0.4	-1.1
Patch foraging water rate 12 sec	1.5	3.1	8.1	2.5	2.8	2.2	-1.7	-1.7	1.4	-2.0	1.8	0.3	0.7	0.0
Patch foraging water rate 18 sec	6.1	9.4	17.0	3.6	3.2	4.1	-3.8	-3.6	3.4	-3.8	1.3	-1.6	-1.2	-1.8
Patch foraging water rate 24 sec	3.0	4.2	7.0	2.3	1.9	2.7	-2.5	-2.5	2.5	-2.4	0.0	-1.5	-1.4	-1.1
Patch foraging water rate 6 sec	2.8	4.1	7.3	2.7	2.5	2.6	-2.5	-2.5	2.2	-2.1	0.9	-0.9	-0.4	-1.1
Seeking ratio, delayed vs. immediate footshock	0.4	0.4	1.4	-0.8	-1.2	-0.4	0.2	0.3	0.0	0.8	-0.8	-0.8	-0.7	-0.2
Distance traveled before self-admin	0.6	0.7	1.5	-0.4	-0.1	-0.8	0.4	0.9	-1.2	0.9	1.1	0.9	1.1	0.6
Distance traveled after self-admin	0.6	0.7	2.0	1.0	1.1	0.1	-0.1	-0.1	-0.4	0.6	0.9	1.2	1.4	0.9
Extensor digitorum longus weight	0.1	0.4	1.0	-0.8	-1.0	-0.3	0.4	0.1	0.1	0.2	-0.9	-0.8	-0.9	-0.5
Bone: elastic displacement	0.9	1.0	3.3	-0.5	-0.6	-1.3	1.2	1.0	-1.1	1.8	0.5	0.9	1.0	-0.1
Bone: elastic work	2.4	3.1	5.4	-1.8	-1.5	-2.3	1.9	2.2	-2.2	2.0	0.2	1.7	1.3	0.9
Bone: endosteal estimation	1.2	2.6	6.7	-2.6	-2.6	-1.3	0.2	1.2	-0.3	-0.2	-2.3	-1.3	-2.0	-0.9
Bone: endosteal perimeter	0.7	1.6	4.3	-1.2	-1.5	-0.1	-0.5	-0.1	0.6	-0.6	-1.9	-1.8	-2.1	-1.1
Epididymis fat weight	5.3	18.0	36.6	-6.1	-5.9	-5.5	5.1	5.0	-4.3	3.9	-3.1	1.0	-0.5	1.7
Delta time in closed arm before/after self-admin	0.3	0.3	0.8	0.5	0.5	0.5	-0.3	-0.5	0.7	-0.9	-0.2	-0.3	-0.4	-0.8
Delta time in open arm before/after self-admin	1.8	1.8	3.1	-1.8	-1.4	-1.7	1.6	1.6	-1.2	1.5	-0.9	0.3	0.1	1.4
Diff in mean of infusions in LGA sessions	1.1	1.4	3.6	-0.2	0.7	-0.8	0.5	1.0	-1.3	0.9	1.8	1.7	1.9	0.9
Delay discount exponential model param	1.7	1.9	5.1	-1.6	-2.1	-0.7	0.6	0.5	0.3	0.8	-2.2	-1.7	-1.7	-1.1
Extinction: sum of active levers before priming	0.3	0.3	0.7	0.4	0.1	0.3	-0.4	-0.6	0.8	0.1	-0.4	-0.8	-0.6	-0.7
Active lever presses in extinction session 6	1.7	1.7	4.2	-1.5	-2.1	-1.6	1.5	1.1	-0.8	1.7	-1.3	-0.1	-0.4	-0.6
Bone: final force	0.2	0.3	0.7	-0.8	-0.5	-0.7	0.0	0.8	-0.8	-0.0	0.1	0.5	0.2	0.3
Bone: final moment	0.1	0.2	0.6	-0.7	-0.5	-0.6	-0.1	0.7	-0.8	-0.0	0.1	0.4	0.2	0.0
Food consumed during 24 hour testing period	0.1	0.1	0.4	-0.5	-0.1	0.0	0.1	0.4	-0.4	-0.7	0.4	0.2	-0.1	0.0
Glucose	0.9	1.4	4.1	-1.4	-2.0	-1.1	1.1	0.5	-0.3	0.9	-1.6	-0.9	-1.3	-1.1
Heart weight	0.8	1.2	4.4	-1.4	-2.1	-1.2	1.0	1.0	-1.1	0.8	-1.1	-0.3	-0.6	-0.5
Delay discount hyperbolic model param	1.4	1.5	4.2	-1.2	-1.7	-0.4	0.3	0.1	0.6	0.6	-2.1	-1.8	-1.7	-1.1
Intermittent access intake day 1-15 change	0.5	1.1	3.0	-1.5	-1.7	-1.0	1.1	0.7	-0.4	0.4	-1.2	-0.8	-1.0	0.1
Intermittent access intake escalation	0.4	0.7	2.2	-1.3	-1.5	-0.8	1.0	0.6	-0.3	0.3	-0.9	-0.8	-0.9	-0.0
Intermittent access intake escalation 2	0.8	0.9	2.2	-1.5	-1.3	-1.0	1.4	0.9	-0.6	0.2	-0.8	-0.4	-0.6	0.8
Intermitt. access day 1 inactive lever presses	0.4	1.5	2.9	0.6	0.1	1.2	-1.0	-1.3	1.4	-1.5	-0.6	-1.7	-1.5	-1.5
Intermitt. access day 15 inactive lever presses	1.4	2.9	9.7	-1.1	-1.9	0.2	0.1	-0.7	1.3	-0.6	-2.3	-3.1	-2.8	-1.2
Intermitt. access escalation Index	0.4	0.6	2.5	-0.5	-0.8	-1.0	0.4	0.7	-0.4	1.6	-0.9	0.5	0.2	-0.7
Intermittent access day 1 total infusions	0.1	0.1	0.6	-0.1	-0.5	-0.5	0.2	-0.1	-0.2	0.6	-0.0	-0.3	-0.0	-0.7
Intermittent access day 15 total infusions	0.7	1.0	3.4	-1.3	-1.8	-1.1	1.0	0.4	-0.5	0.7	-0.8	-1.0	-0.8	-0.8
Intermittent access terminal intake (last 3 days)	1.0	1.3	3.8	-1.6	-2.0	-1.4	1.3	0.8	-0.8	0.9	-0.7	-0.8	-0.6	-0.7
Intermittent access total infusions	0.7	0.8	2.6	-1.1	-1.6	-1.0	0.9	0.4	-0.3	0.9	-1.1	-0.9	-0.7	-0.7
Intermittent access day 1 locomotion	0.3	0.4	1.1	0.9	0.7	0.0	-0.2	-0.3	-0.4	0.4	1.0	0.7	1.0	-0.2
Intermittent access day 15 total locomotion	0.3	0.5	1.0	-0.6	-0.9	-0.9	1.0	0.5	-0.6	0.9	-0.6	-0.1	-0.1	0.6
Intermittent access total locomotion	0.1	0.1	0.4	0.3	0.0	-0.3	0.3	-0.1	-0.3	0.6	0.3	0.3	0.5	0.3
Intermittent access standard deviation	0.1	0.2	0.7	-0.1	-0.4	0.1	0.3	-0.3	0.3	-0.2	-0.4	-0.9	-0.6	-0.0
Left kidney weight	0.8	3.7	8.3	-2.9	-2.8	-2.4	2.1	2.1	-1.7	1.9	-1.7	0.2	-0.4	0.4
Right kidney weight	0.3	1.2	3.4	-1.7	-1.8	-1.1	0.7	1.1	-0.7	1.0	-1.3	-0.4	-0.6	-0.3
Cocaine induced anxiety	0.3	0.4	1.2	0.6	-0.1	0.5	-0.7	-0.8	0.4	0.2	-0.4	-0.8	-0.5	-1.1
Post-drug Anxiety	0.3	0.3	0.8	-0.8	-0.9	-0.7	0.7	0.6	-0.6	0.6	-0.4	-0.2	-0.2	0.1
Baseline Anxiety	2.2	2.5	5.4	-1.9	-1.2	-1.9	2.3	2.0	-1.6	1.0	-0.0	1.1	0.6	2.2
Tail length	0.2	0.9	2.3	-1.5	-1.5	-1.0	0.9	1.1	-0.8	0.4	-1.0	0.2	-0.6	0.4
Length with tail	1.1	4.7	13.1	-3.5	-3.6	-2.3	2.1	2.3	-1.5	1.0	-2.4	-0.4	-1.5	-0.0
Length without tail	1.0	3.3	8.8	-3.0	-2.9	-2.0	2.1	2.0	-1.2	0.6	-1.8	-0.5	-1.0	0.3
Times rat made contact with spout	2.2	2.5	5.2	-2.1	-2.3	-2.0	2.0	1.7	-1.5	1.7	-1.1	0.4	-0.2	0.2
Lifetime Intake	0.5	0.7	1.9	-0.9	-1.4	-0.8	0.7	0.4	-0.1	0.8	-1.1	-0.8	-0.7	-0.5
Liver weight, left	0.9	1.5	4.3	-2.1	-2.0	-1.2	0.9	1.2	-0.8	0.4	-1.6	-0.5	-1.0	0.1
Liver weight, right	1.0	1.8	4.6	-2.1	-2.1	-1.3	1.7	1.4	-1.1	0.6	-1.3	-0.2	-0.7	0.5
Locomotor activity	0.1	0.1	0.4	-0.3	-0.5	-0.5	0.6	0.2	-0.2	0.2	-0.3	0.1	-0.0	-0.1
Locomotor testing distance	0.0	0.1	0.2	0.5	0.3	0.1	0.3	-0.3	0.1	-0.3	0.1	0.2	0.2	0.0
Locomotor testing rearing	0.1	0.2	0.6	-0.1	-0.2	-0.2	0.8	0.2	-0.1	-0.2	-0.8	0.3	-0.0	0.5
Locomotion in novel chamber	1.7	2.2	4.6	1.5	0.7	1.6	-1.8	-1.7	2.2	-1.1	-1.1	-1.3	-1.3	-1.4
Locomotion in novel chamber post-restriction	1.6	2.6	5.2	1.8	1.5	2.0	-2.1	-1.9	2.3	-1.7	-0.3	-0.7	-0.8	-1.4
Fecal boli incidents, locomotor time 1	1.6	2.3	3.8	1.0	0.4	1.8	-2.0	-1.7	1.8	-1.8	-0.7	-1.6	-1.7	-1.4
Change in fecal boli incidents, locomotor task	0.2	0.2	1.3	0.2	-0.1	-0.2	0.0	0.0	0.3	0.5	-0.4	-0.1	0.0	-1.1
Time >=10cm from walls, locomotor time 1	0.4	0.4	1.2	0.7	0.5	0.7	-0.6	-0.6	0.7	-1.1	-0.1	-0.3	-0.4	-1.0
Bouts of movement, locomotor time 1	1.4	1.6	3.7	1.2	1.2	1.7	-1.9	-1.6	1.3	-1.5	0.7	-0.9	-0.7	-0.4
Total resting periods, locomotor time 1	2.1	2.3	5.1	1.4	1.3	1.9	-2.3	-1.9	1.6	-1.7	0.7	-1.3	-1.0	-0.8
Rest time, locomotor task time 1	0.9	1.1	2.7	0.4	0.2	1.0	-1.4	-1.1	1.3	-0.9	-0.4	-1.6	-1.5	-0.8
Distance moved, locomotor task time 1	1.1	1.6	5.1	1.1	1.5	0.2	0.1	-0.0	-0.8	0.1	2.3	1.8	2.2	0.5
Vertical activity count, locomotor time 1	0.3	0.7	1.9	-0.5	-0.1	-0.7	0.8	0.9	-1.1	0.2	0.5	1.4	1.1	0.7
Time >=10cm from walls, locomotor time 2	0.5	0.8	1.8	-1.2	-1.4	-1.2	1.2	0.9	-0.8	0.7	-0.9	0.0	-0.4	0.1
Bouts of movement, locomotor time 2	0.2	0.4	1.7	-0.2	-0.4	-0.7	0.3	0.2	-0.9	1.3	0.3	0.5	0.6	0.1
Total resting periods, locomotor time 2	0.2	0.3	1.4	-0.3	-0.6	-0.7	0.3	0.2	-0.8	1.2	0.0	0.3	0.3	-0.1
Rest time, locomotor task time 2	0.2	0.2	0.6	0.0	-0.1	0.3	-0.6	-0.3	0.4	-0.4	0.1	-0.7	-0.5	-0.7
Distance moved, locomotor task time 2	0.7	0.8	2.4	1.0	1.4	0.6	-0.2	-0.5	-0.2	-0.1	1.5	0.9	1.2	0.9
Vertical activity count, locomotor time 2	0.3	0.4	1.1	0.2	0.6	-0.1	0.5	0.2	-0.6	0.3	0.5	1.0	0.9	1.0
Light reinforcement 1	0.4	1.0	2.4	-0.1	-0.3	0.8	-0.9	-0.8	1.2	-1.1	-1.0	-1.3	-1.5	-1.0
Light reinforcement 2	1.3	2.0	4.9	0.0	-1.1	0.6	-1.0	-1.1	1.5	0.7	-2.2	-1.8	-2.1	-1.8
Bone: marrow area	1.2	2.6	6.8	-2.5	-2.6	-1.3	0.2	1.1	-0.3	-0.1	-2.3	-1.4	-2.1	-0.9
Bone: maximum diameter	0.5	0.9	2.5	-1.6	-1.5	-0.7	0.6	0.7	-0.5	-0.1	-1.0	-1.0	-1.1	0.3
Bone: maximum force	0.1	0.2	0.7	-0.8	-0.4	-0.4	-0.0	0.6	-0.5	-0.5	-0.0	0.1	0.1	0.2
Bone: maximum moment	0.1	0.2	0.6	-0.7	-0.3	-0.4	-0.1	0.6	-0.5	-0.4	0.1	0.2	0.2	0.0
Mean time between licks in bursts	0.2	0.4	1.7	0.7	0.8	0.8	-1.3	-0.5	0.7	-0.7	-0.3	-0.2	-0.1	-0.3
Mean num. licks in bursts	0.7	1.0	3.6	-1.1	-1.9	-1.0	1.1	0.5	-0.5	1.1	-0.9	-0.6	-0.8	-1.0
Cd content in liver	0.3	0.3	2.3	-0.1	0.6	0.3	-0.3	0.2	0.1	-1.5	0.3	0.3	-0.1	0.2
Co content in liver	0.6	0.6	2.6	0.8	0.2	0.7	-0.8	-1.0	0.8	-0.6	0.0	-0.5	-0.6	-1.6
Cu content in liver	0.4	0.4	0.8	0.6	0.5	0.7	-0.9	-0.8	0.4	-0.7	0.8	-0.6	-0.2	-0.5
Fe content in liver	1.0	1.2	2.2	-1.3	-0.9	-1.4	1.4	1.3	-1.5	1.0	0.1	0.8	0.8	1.0
K content in liver	1.8	1.7	4.4	1.8	1.9	0.6	-0.6	-0.4	-0.3	0.1	2.1	1.3	1.9	0.9
Mg content in liver	0.2	0.2	0.7	0.2	0.2	-0.2	0.4	0.2	-0.3	0.6	0.3	0.3	0.7	0.8
Mn content in liver	1.4	1.6	2.8	1.2	-0.1	1.0	-1.4	-1.5	1.5	0.2	-1.3	-1.5	-1.3	-1.7
Na content in liver	1.5	1.6	3.3	0.1	0.1	-1.0	1.7	0.8	-1.3	1.7	0.9	1.5	1.8	1.4
Rb content in liver	0.2	0.3	0.8	-0.6	0.1	-0.2	0.1	0.5	-0.5	-0.7	0.6	0.2	0.4	0.9
Se content in liver	0.5	0.6	1.3	-0.3	-0.0	-0.7	0.8	0.9	-1.1	0.3	1.1	1.1	1.1	0.2
Sr content in liver	0.8	0.7	1.4	0.7	0.4	0.9	-1.0	-1.0	1.0	-0.7	-0.3	-0.7	-0.8	-1.2
Zn content in liver	0.4	0.4	1.2	0.7	1.0	0.5	0.1	-0.3	-0.2	-0.6	1.1	0.8	0.8	0.3
Bone: minimum diameter	0.3	0.6	1.4	-1.1	-1.2	-0.9	0.9	0.8	-0.7	0.5	-0.7	-0.1	-0.3	-0.3
Time in familiar zone, hab. session 1	0.9	0.9	2.0	-0.4	0.5	-0.7	0.6	1.0	-1.0	0.4	1.2	1.4	1.4	0.8
Time in novel zone, hab. session 1	0.6	0.6	2.5	-0.2	-0.9	0.1	0.2	-0.3	0.5	-0.2	-1.6	-1.1	-1.3	0.1
Total zone transitions, hab. session 1	0.7	1.0	2.8	1.3	0.9	1.0	-1.7	-1.1	0.8	-0.1	0.8	-0.4	-0.0	-1.4
Total locomotion distance, hab. session 1	0.9	1.3	2.6	1.6	1.2	1.4	-1.5	-1.6	1.0	-0.5	1.1	-0.7	-0.1	-1.0
Locomotion velocity, hab. session 1	1.3	1.8	3.5	1.9	1.5	1.6	-1.8	-1.7	1.1	-0.6	1.3	-0.4	0.1	-1.2
Time in familiar zone, hab. session 2	0.2	0.2	0.4	0.3	0.1	0.3	-0.1	-0.5	0.6	0.1	-0.6	-0.6	-0.4	-0.2
Time in novel zone, hab. session 2	0.3	0.3	0.9	-0.9	-0.9	-0.7	0.5	0.8	-0.5	0.3	-0.4	0.2	-0.3	0.1
Total zone transitions, hab. session 2	0.5	0.7	2.0	0.2	-0.4	0.5	-1.1	-0.6	0.7	-0.2	-0.9	-0.9	-1.1	-1.4
Total locomotion distance, hab. session 2	1.7	2.2	3.9	0.8	-0.2	1.2	-1.5	-1.6	1.8	-0.7	-1.6	-1.9	-2.0	-1.9
Locomotion velocity, hab. session 2	1.8	2.4	3.8	1.3	0.3	1.5	-1.8	-1.8	1.9	-0.9	-1.2	-1.7	-1.7	-1.9
Novel to familiar place preference ratio	0.2	0.2	1.9	-0.4	0.0	-0.0	0.0	0.3	0.2	-0.4	-0.3	-0.3	-0.3	1.4
Novelty place preference	0.3	0.3	2.7	-0.4	0.2	-0.1	0.0	0.4	0.0	-0.4	-0.2	0.0	-0.0	1.6
Time in novel zone, NPP test	0.4	0.4	2.6	-0.8	-0.3	-0.4	0.2	0.7	-0.1	-0.2	-0.6	-0.1	-0.2	1.6
Total zone transitions, NPP test	0.6	0.9	2.6	1.1	0.7	0.9	-1.6	-1.0	0.8	-0.4	0.3	-0.6	-0.4	-1.5
Total locomotion distance, NPP test	1.8	2.4	4.5	1.4	0.6	1.7	-1.8	-1.9	1.9	-1.2	-0.7	-1.6	-1.5	-2.1
Locomotion velocity, NPP test	1.9	2.7	4.6	1.8	1.0	1.9	-2.1	-2.0	1.9	-1.3	-0.3	-1.4	-1.3	-2.1
Intraocular pressure	1.8	2.6	5.5	1.0	0.8	1.9	-2.3	-1.7	2.1	-2.0	-0.4	-1.6	-1.6	-1.4
Delta distance traveled before/after self-admin	0.6	0.6	1.6	1.3	1.3	0.6	-0.3	-0.6	0.6	-0.2	-0.1	0.8	0.7	0.9
Delta ambulatory time before/after self-admin	0.4	0.5	1.2	1.1	1.1	0.7	-0.3	-0.7	0.7	-0.4	-0.3	0.6	0.3	1.1
Parametrial fat weight	12.5	29.4	60.1	-7.8	-7.2	-7.0	6.3	6.3	-5.4	5.6	-3.9	1.7	-0.3	2.0
Pavlov. Cond. lever latency	2.4	3.0	8.3	-1.7	-2.7	-0.9	0.7	0.2	0.3	1.4	-2.9	-2.2	-2.3	-1.0
Pavlov. Cond. magazine entry latency	0.8	1.0	2.9	-0.1	0.6	-0.6	1.0	0.9	-1.0	0.5	1.1	1.7	1.6	1.0
Pavlov. Cond. change in total contacts	3.2	3.4	8.3	1.6	2.9	0.9	-0.2	-0.1	-0.3	-1.5	2.9	2.4	2.5	1.6
Pavlov. Cond. index score	2.2	2.8	7.1	1.0	2.2	0.2	0.4	0.5	-0.9	-0.5	2.6	2.6	2.7	1.6
Pavlov. Cond. latency score	2.3	3.0	7.3	1.5	2.6	0.6	-0.1	0.1	-0.5	-0.8	2.7	2.5	2.6	1.4
Pavlov. Cond. lever contacts	1.9	2.2	7.1	1.0	2.0	0.3	-0.1	0.3	-0.7	-0.9	2.7	2.2	2.3	1.0
Pavlov. Cond. magazine entry number	1.1	1.3	3.9	-0.0	-0.9	0.5	-0.9	-0.9	1.1	-0.1	-1.5	-2.0	-1.8	-1.2
Pavlov. Cond. intertrial magazine entries	3.1	3.7	8.3	0.4	-0.7	1.3	-1.5	-1.7	2.3	-0.8	-2.4	-2.9	-2.8	-2.2
Pavlov. Cond. lever-magazine prob. diff.	2.7	3.3	8.7	0.9	2.2	-0.0	0.6	0.7	-1.2	-0.4	2.8	2.9	3.0	1.9
Pavlov. Cond. response bias	1.7	2.1	5.5	0.2	1.4	-0.4	0.8	1.0	-1.3	-0.3	2.2	2.3	2.3	1.6
Pavlov. Cond. lever latency	2.6	3.5	7.2	2.7	2.4	2.4	-2.2	-2.4	2.1	-1.6	1.0	-0.9	-0.0	-0.8
Pavlov. Cond. magazine entry latency	2.1	2.5	7.0	-2.1	-2.7	-1.2	0.9	0.9	-0.3	0.8	-2.5	-1.3	-2.0	-0.8
Pavlov. Cond. change in total contacts	3.1	4.9	9.2	-3.0	-2.8	-3.0	2.6	2.7	-2.5	2.3	-1.3	0.9	0.2	0.3
Pavlov. Cond. index score	3.0	4.1	9.2	-3.0	-3.0	-2.5	2.2	2.3	-1.8	1.7	-1.9	0.2	-0.7	0.3
Pavlov. Cond. latency score	2.5	3.3	7.0	-2.7	-2.5	-2.3	2.1	2.1	-1.7	1.6	-1.5	0.4	-0.4	0.4
Pavlov. Cond. lever contacts	2.7	3.8	8.1	-2.8	-2.5	-2.5	2.2	2.4	-2.1	1.7	-1.3	0.8	-0.1	0.9
Pavlov. Cond. magazine entry number	2.3	2.8	7.5	2.5	2.7	1.8	-1.5	-1.5	1.2	-1.3	1.9	0.6	1.2	0.5
Pavlov. Cond. intertrial magazine entries	1.0	1.5	4.4	1.7	2.1	1.2	-0.5	-0.8	0.6	-1.0	1.4	0.9	1.1	1.1
Pavlov. Cond. lever-magazine prob. diff.	3.4	4.5	9.6	-3.1	-3.0	-2.7	2.4	2.5	-2.1	2.1	-1.7	0.5	-0.4	0.4
Pavlov. Cond. response bias	2.9	4.0	9.9	-3.1	-3.2	-2.4	2.0	2.1	-1.6	1.5	-2.1	-0.2	-1.1	0.2
Time in closed arm before self-admin	0.1	0.2	1.0	-0.3	-0.5	0.1	-0.3	-0.2	0.1	-0.0	-0.0	-0.5	-0.5	-1.0
Time in closed arm after self-admin	0.9	1.0	3.5	0.5	0.1	0.9	-0.9	-1.1	1.0	-0.9	-0.1	-1.1	-1.0	-1.9
Time in open arm before self-admin	0.2	0.3	0.8	0.4	0.3	-0.3	0.4	0.3	-0.4	0.5	0.1	0.9	0.8	0.7
Time in open arm after self-admin	1.9	2.1	5.4	-1.0	-0.8	-1.8	1.6	1.6	-1.6	2.3	-0.2	1.2	1.3	1.4
Bone: periosteal estimation	0.6	1.3	3.9	-1.9	-2.0	-1.2	0.6	1.0	-0.7	0.2	-1.3	-0.7	-1.1	-0.3
Bone: periosteal perimeter	0.3	0.6	1.5	-0.9	-1.2	-0.3	0.0	0.2	0.0	0.1	-1.2	-1.0	-1.1	-0.3
Bone: post-yield work	0.3	0.4	1.1	-0.4	-0.1	0.4	-0.4	-0.2	0.6	-1.0	-0.6	-1.1	-0.8	-0.7
Progressive ratio test 1 active lever presses	0.4	0.4	1.2	-0.8	-1.1	-0.8	0.6	0.5	-0.4	0.8	-0.6	-0.4	-0.2	-0.5
Progressive ratio test 1 breakpoint	0.4	0.5	1.2	-0.9	-1.1	-0.9	0.6	0.6	-0.5	0.8	-0.5	-0.4	-0.2	-0.5
Progressive ratio test 1 inactive lever presses	1.0	1.4	4.5	-0.5	-1.0	0.4	-0.2	-0.6	1.2	-0.8	-1.7	-2.1	-2.1	-0.5
Progressive ratio test 2 active lever presses	0.3	0.3	1.0	-0.7	-1.0	-0.5	0.5	0.2	-0.2	0.5	-0.5	-0.7	-0.5	-0.2
Progressive ratio test 2 breakpoint	0.4	0.4	1.3	-0.8	-1.1	-0.6	0.6	0.2	-0.3	0.6	-0.6	-0.8	-0.5	-0.3
Progressive ratio test 2 inactive lever presses	1.2	2.0	6.4	-1.3	-2.1	-0.6	0.7	0.0	0.4	0.6	-2.5	-1.9	-2.1	-0.1
Incentive Sensitization - Responses	0.3	0.4	1.5	-0.3	-0.8	-0.0	-0.0	-0.2	0.5	0.4	-1.2	-1.0	-1.0	-0.2
Incentive Sensitization - Breakpoint	0.4	0.5	2.0	-0.5	-1.0	-0.2	0.2	-0.1	0.4	0.6	-1.4	-1.0	-1.1	-0.3
Sum of active levers in priming session hrs 5-6	0.6	0.5	2.0	0.4	0.1	0.4	-0.7	-0.7	0.9	-0.0	-0.3	-1.0	-0.7	-1.4
Progressive ratio	1.8	2.9	5.7	1.1	0.4	1.8	-1.9	-1.8	2.4	-1.2	-1.3	-2.1	-1.9	-2.0
Food seeking constrained by brief footshock	0.8	1.0	2.6	1.6	1.5	0.7	-1.1	-0.8	0.4	0.4	1.2	0.4	1.1	-0.7
Seeking ratio, punishment vs. effort	2.1	3.0	5.3	-0.8	-0.1	-1.8	1.6	1.7	-2.3	2.0	1.4	2.1	2.2	1.6
Retroperitoneal fat weight	12.7	54.2	111.6	-10.6	-9.2	-9.6	8.9	9.2	-8.0	6.6	-3.7	2.9	0.7	3.6
Reaction time number correct	1.4	2.6	4.5	1.4	1.0	2.0	-2.1	-1.8	2.1	-1.8	-1.1	-1.4	-1.7	-0.7
Reaction time mean minus median	0.8	2.0	4.4	-2.1	-2.1	-1.7	1.5	1.7	-1.0	1.4	-1.3	-0.0	-0.4	-0.1
Reaction time mean minus median AUC	0.7	1.8	4.2	-1.9	-2.0	-1.5	1.3	1.5	-0.6	1.0	-1.8	-0.2	-0.8	-0.1
Reaction time num false alarms	1.5	2.1	4.3	2.1	1.3	1.8	-1.5	-2.0	1.1	-1.3	1.1	-0.6	-0.3	-1.5
Reaction time num false alarms AUC	1.1	1.7	3.9	2.0	1.3	1.7	-1.3	-1.8	1.0	-1.2	1.1	-0.4	-0.2	-1.1
Reaction time trials correct on left	1.4	2.6	4.5	1.4	1.0	2.0	-2.1	-1.8	2.1	-1.8	-1.1	-1.4	-1.7	-0.7
Reaction time trials on left	1.4	2.6	4.5	1.4	0.9	2.0	-2.0	-1.8	2.1	-1.8	-1.3	-1.4	-1.8	-0.7
Reaction time mean	2.0	3.2	7.6	-2.8	-2.6	-2.3	1.7	2.2	-1.6	1.9	-1.4	0.2	-0.4	0.1
Reaction time mean AUC	1.7	2.7	5.8	-2.4	-2.4	-2.1	1.6	2.0	-1.5	1.9	-1.2	0.3	-0.2	-0.2
Median of all reaction times	1.9	2.6	6.1	-2.5	-2.3	-2.1	1.4	2.1	-1.6	1.7	-1.1	0.3	-0.3	0.1
Reaction time omissions	0.6	0.8	3.6	-1.3	-1.3	-0.6	0.2	0.7	-0.0	0.3	-1.9	-0.5	-1.0	-0.1
Reaction time false alarm rate	0.4	0.5	1.8	1.1	0.7	0.6	-0.3	-0.9	0.1	-0.3	1.3	0.0	0.4	-0.7
Reaction time premature initiation rate	0.1	0.2	0.5	0.1	-0.2	0.3	-0.5	-0.4	0.3	-0.4	0.1	-0.6	-0.6	-0.7
Reaction time premature initiations	0.8	1.4	2.2	0.9	0.3	1.3	-1.5	-1.4	1.4	-1.2	-0.4	-1.3	-1.4	-1.1
Std. dev. reaction times	1.3	2.4	5.7	-2.4	-2.2	-1.9	1.7	2.0	-1.3	1.4	-1.3	0.1	-0.3	0.2
Reaction time trials completed	1.4	2.6	4.5	1.4	0.9	2.0	-2.0	-1.8	2.1	-1.8	-1.3	-1.4	-1.8	-0.7
Reaction time trials AUC	1.6	3.1	5.3	1.3	0.8	2.1	-2.2	-1.9	2.3	-2.0	-1.4	-1.7	-2.1	-0.8
Run reversals in cocaine runway, females	2.0	2.0	3.6	-1.4	-1.3	-1.7	1.9	1.8	-1.5	1.4	-0.9	1.3	0.6	1.1
Run reversals in cocaine runway, males	2.4	2.4	4.9	-1.4	-0.6	-1.6	2.0	1.7	-2.2	0.8	1.1	1.9	1.7	1.4
Latency to leave start box in cocaine runway	0.7	0.8	1.6	0.7	-0.2	0.6	-0.8	-1.1	1.1	-0.0	-1.1	-1.1	-1.0	-1.2
Latency to leave start box in cocaine runway, F	0.4	0.4	1.4	-0.2	-0.7	0.1	0.0	-0.5	0.5	-0.3	-1.0	-1.0	-1.2	-0.4
Latency to leave start box in cocaine runway, M	1.4	1.3	4.0	1.3	0.3	1.0	-1.5	-1.3	1.4	0.3	-0.9	-1.0	-0.6	-2.0
Std. dev. time between licks in bursts	0.5	0.7	1.6	1.1	1.3	1.0	-1.3	-0.8	0.9	-1.0	0.3	0.2	0.1	-0.3
Total sessions with >9 infusions	0.5	0.6	1.6	-0.9	-1.3	-0.9	0.9	0.5	-0.4	1.0	-1.1	-0.4	-0.4	-0.2
Short access day 1 total inactive lever presses	1.8	2.4	6.1	0.2	-0.6	1.1	-1.0	-1.4	1.9	-1.3	-1.8	-2.4	-2.5	-1.4
Short access day 10 total inactive lever presses	1.1	2.6	8.2	-0.3	-1.1	0.8	-0.6	-1.1	1.7	-1.3	-2.4	-2.4	-2.9	-1.1
Short access day 1 total infusions	0.5	0.7	1.3	0.7	0.3	1.0	-0.7	-1.0	1.1	-0.8	-0.5	-1.1	-0.9	-0.6
Short access day 10 total infusions	0.3	0.4	1.2	-0.6	-1.0	-0.5	0.5	0.0	0.2	0.2	-1.1	-0.9	-0.9	-0.6
Short access total infusions	0.4	0.5	1.2	-0.8	-1.1	-0.7	0.8	0.4	-0.1	0.6	-1.1	-0.6	-0.6	-0.3
Short access day 1 locomotion	0.2	0.2	0.6	-0.2	-0.5	-0.4	0.8	0.2	-0.3	0.7	-0.6	0.1	-0.0	0.3
Short access day 10 total locomotion	0.3	0.5	1.7	0.7	0.7	0.9	-0.5	-0.8	0.8	-1.3	-0.0	-0.5	-0.5	-0.4
Short access total locomotion	0.1	0.1	0.3	0.6	0.4	0.1	0.1	-0.2	-0.2	0.2	0.3	0.5	0.5	0.1
One hour access (0.3 mA shock)	0.5	0.6	1.7	-0.1	-0.5	-0.3	0.2	-0.4	0.9	0.9	-1.1	-1.3	-0.9	-0.9
Compulsive drug intake	1.0	1.2	3.2	1.4	1.8	1.0	-1.4	-1.1	1.5	-0.2	0.5	-0.4	0.1	-0.9
One hour access (shock baseline)	0.5	0.7	1.9	-1.0	-1.4	-1.0	1.4	0.7	-0.7	0.6	-0.6	-0.3	-0.3	0.5
Social response proportion	3.2	3.6	6.0	-2.2	-2.2	-2.4	2.4	2.3	-1.8	2.4	-1.3	1.2	0.4	0.4
Social responses	0.2	0.2	0.7	-0.5	-0.5	-0.3	0.8	0.6	-0.7	-0.1	0.1	0.5	0.1	0.6
Social time	0.7	1.0	1.9	-0.9	-0.9	-1.2	1.0	1.2	-1.4	0.8	-0.3	1.2	0.6	0.8
Soleus weight	0.0	0.1	0.4	-0.2	-0.2	0.1	0.0	-0.1	0.4	-0.3	-0.5	-0.5	-0.7	-0.2
Bone: stiffness	0.1	0.2	0.7	-0.5	-0.3	0.2	-0.4	-0.1	0.1	-0.8	-0.4	-0.5	-0.5	0.1
Tibialis anterior weight	0.4	1.2	3.4	-1.8	-1.4	-1.3	1.4	1.3	-0.8	0.7	-1.0	0.0	-0.3	0.7
Time to tail flick, vehicle, before self-admin	1.9	2.0	5.7	-1.7	-2.4	-1.0	0.5	0.5	-0.0	1.0	-1.8	-1.5	-1.6	-1.7
Time to tail flick, vehicle, after self-admin	0.3	0.3	1.6	0.0	0.0	0.3	-0.1	-0.3	-0.2	-0.6	1.2	-0.5	-0.1	-1.3
Time to tail flick, test, before self-admin	0.2	0.2	1.0	-0.0	0.1	0.1	-0.5	-0.2	0.2	0.1	0.4	-0.5	-0.1	-1.0
Time to tail flick, test, after self-admin	2.4	2.5	7.2	-0.0	-0.5	1.2	-1.1	-1.3	1.7	-1.8	-1.2	-2.7	-2.5	-1.2
Delta time to tail flick, vehicle, before/after SA	1.0	1.0	2.8	1.1	1.3	1.3	-0.7	-0.9	0.5	-1.7	1.4	-0.2	0.1	0.1
Delta time to tail flick, test, before/after SA	0.7	0.7	2.0	0.1	-0.3	0.8	-0.5	-0.7	0.9	-1.1	-1.0	-1.3	-1.4	0.0
Tibia length	1.4	4.0	7.9	-2.8	-2.8	-2.7	1.9	2.4	-2.4	2.1	-0.5	0.8	0.3	-0.7
Ambulatory time before self-admin	0.6	0.9	1.8	-0.7	-0.4	-1.0	0.7	1.1	-1.3	1.0	0.8	0.9	1.0	0.6
Ambulatory time after self-admin	0.7	0.9	2.2	0.9	1.1	0.1	0.0	0.1	-0.4	0.3	0.9	1.4	1.5	1.5
Bone: tissue strength	0.5	0.5	1.1	-0.9	-0.6	-1.1	0.8	1.0	-0.7	0.7	-0.3	0.8	0.3	-0.2
Total heroin consumption	1.1	1.3	3.5	-0.1	-1.1	-0.0	-0.3	-0.5	0.9	0.5	-1.9	-1.6	-1.6	-1.9
Bone: trabecular number	0.1	0.2	0.6	0.7	0.8	0.5	-0.1	-0.2	0.2	-0.6	0.5	0.5	0.5	0.1
Bone: trabecular spacing	1.3	1.7	3.3	-1.8	-1.4	-1.6	1.8	1.4	-1.7	1.0	0.1	0.2	0.4	1.3
Bone: trabecular thickness	0.2	0.2	0.5	0.5	0.7	0.3	-0.6	-0.2	0.2	-0.2	0.5	0.6	0.4	-0.7
Bone: trabecular tissue density	0.9	1.3	3.9	-0.5	0.1	-1.1	1.0	1.1	-1.4	0.8	0.9	1.4	1.5	2.0
Water consumed over 24 hours	0.6	0.7	2.5	-0.4	-1.0	0.2	0.1	-0.4	0.6	-0.5	-1.1	-1.3	-1.6	-1.0
Number of responses in last shaping day	1.1	1.2	2.7	0.5	0.2	1.3	-0.7	-1.2	1.5	-1.4	-0.4	-1.6	-1.4	-0.4