Hub : Genes

Dstn

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain mRNA stability Dstn 0.5 0.15 0.0e+00 0.36 0.33 0.37 0.26 2.2e-35 4.8e-31 1.1e-35 1.2e-24
2 LHb mRNA stability Dstn 0.33 0.15 9.7e-07 0.24 0.24 0.24 0.24 2.5e-06 1.9e-06 1.9e-06 2.3e-06
3 BLA mRNA stability Dstn 0.44 0.16 0.0e+00 0.26 0.08 0.26 0.06 4.2e-14 4.4e-05 2.1e-14 2.8e-04
4 RMTg mRNA stability Dstn 0.1 0.08 6.7e-03 0.04 0.06 0.05 0.05 2.9e-02 8.3e-03 1.4e-02 1.8e-02
5 OFC mRNA stability Dstn 0.32 0.15 7.1e-07 0.18 0.21 0.21 0.2 5.5e-05 1.3e-05 1.3e-05 1.4e-05
6 IL mRNA stability Dstn 0.58 0.13 2.5e-14 0.33 0.28 0.36 0.3 8.2e-09 1.5e-07 1.8e-09 8.0e-08
7 NAcc mRNA stability Dstn 0.28 0.13 0.0e+00 0.32 0.28 0.32 0.32 2.1e-38 4.8e-33 2.2e-37 1.5e-37
8 pVTA mRNA stability Dstn 0.1 0.06 1.1e-04 0.09 0.07 0.09 0.06 9.1e-05 5.0e-04 9.4e-05 9.3e-04
9 Liver mRNA stability Dstn 0.63 0.16 0.0e+00 0.37 0.39 0.38 0.37 1.3e-43 8.2e-46 5.1e-45 3.7e-43
10 PL mRNA stability Dstn 0.54 0.14 0.0e+00 0.39 0.25 0.41 0.29 7.2e-45 9.2e-28 4.7e-48 9.4e-32
11 Adipose mRNA stability Dstn 0.8 0.07 0.0e+00 0.57 0.6 0.6 0.59 2.8e-76 1.1e-82 1.5e-84 1.0e-80
12 NAcc gene expression Dstn 0.02 0.02 6.0e-03 0.01 0.01 0.02 0.02 7.5e-03 3.5e-02 3.0e-03 5.2e-03
13 Adipose gene expression Dstn 0.11 0.07 1.1e-08 0.03 0.04 0.04 0.04 3.5e-04 1.6e-05 8.8e-06 1.7e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.10.10.40.3-0.30.3-0.30.30.30.40.4-0.40.40.40.6-0.2
Area under the delay curve0.91.06.80.6-0.70.2-0.60.30.80.50.4-0.70.40.32.6-1.7
BMI with tail9.129.635.7-5.85.7-6.05.8-5.8-5.5-5.8-5.85.4-5.6-5.4-4.6-3.1
BMI without tail8.217.022.2-4.14.4-4.54.4-4.4-4.6-4.1-4.24.0-4.1-3.7-4.7-1.3
Body weight11.949.859.7-7.57.5-7.77.6-7.6-7.6-7.3-7.46.9-7.0-6.7-6.5-2.9
Weight adjusted by age0.50.51.5-0.70.8-0.60.7-0.8-0.9-0.8-0.70.5-0.8-0.4-1.20.4
Bone surface0.30.60.9-0.60.9-0.80.8-0.8-0.9-0.7-0.70.7-0.7-0.7-0.90.2
Bone volume0.10.20.4-0.40.6-0.40.5-0.4-0.6-0.4-0.40.4-0.4-0.4-0.40.3
Breakpoint value in progressive ratio session0.60.71.8-0.80.8-0.80.8-0.8-0.9-0.6-0.80.7-0.8-0.8-1.40.2
Number of licking bursts0.10.10.7-0.0-0.30.2-0.20.10.5-0.0-0.0-0.0-0.0-0.20.5-0.9
Context. condit. distance diff. score0.00.00.2-0.2-0.10.2-0.00.10.3-0.1-0.10.2-0.1-0.20.4-0.1
Locomotion velocity, session 10.80.83.21.0-0.71.0-0.80.90.40.80.8-0.90.90.90.21.8
Locomotion distance, session 14.05.16.32.5-2.32.5-2.42.42.12.32.3-2.32.32.21.61.9
Locomotion velocity, session 21.72.03.71.9-1.61.6-1.61.51.51.41.4-1.51.41.40.40.7
Locomotion distance, session 24.15.88.02.6-2.42.8-2.52.72.22.42.4-2.32.42.30.92.8
Locomotion velocity, session 33.84.55.92.4-2.22.2-2.32.22.02.22.2-2.32.22.21.41.2
Locomotion distance, session 31.71.92.61.6-1.51.4-1.51.51.41.41.4-1.51.51.40.90.4
Stereotopy head waving bouts, day 30.10.10.1-0.30.3-0.20.2-0.2-0.3-0.2-0.20.2-0.2-0.2-0.30.3
Stereotopy head waving duration, day 30.10.20.2-0.50.5-0.40.4-0.4-0.4-0.4-0.40.4-0.4-0.5-0.40.1
Locomotion velocity, session 70.60.61.80.8-0.70.9-0.70.90.60.80.8-0.50.80.70.21.3
Locomotion distance, session 70.10.21.9-0.10.00.4-0.10.20.1-0.1-0.10.4-0.1-0.3-0.11.4
Stereotopy head waving bouts, day 70.10.10.4-0.30.5-0.50.5-0.4-0.6-0.3-0.30.3-0.3-0.3-0.1-0.1
Stereotopy head waving duration, day 70.20.20.40.6-0.40.2-0.40.40.20.60.6-0.60.60.60.5-0.2
Locomotion velocity, session 80.70.82.60.9-0.71.0-0.80.90.50.80.8-0.80.90.90.41.6
Locomotion distance, session 82.13.15.11.7-1.82.3-1.92.01.91.61.6-1.41.61.41.02.1
Degree of sensitization distance1.91.92.9-1.61.5-1.11.5-1.3-1.4-1.5-1.51.7-1.5-1.5-1.10.8
Degree of sensitization stereotypy0.30.30.6-0.40.6-0.80.6-0.7-0.7-0.5-0.50.4-0.5-0.5-0.3-0.6
Conditioned locomotion0.10.11.00.20.00.1-0.10.2-0.30.20.2-0.10.20.2-0.31.0
Cocaine response after cond. corrected1.21.42.51.1-1.11.4-1.21.31.11.21.2-0.91.21.00.91.6
Cocaine response after cond. not corrected2.22.43.31.5-1.61.8-1.61.81.51.61.6-1.31.61.31.31.7
Cocaine response before conditioning0.20.20.40.4-0.50.5-0.50.50.50.40.4-0.40.40.30.6-0.2
Saline control response2.02.63.8-1.91.7-1.21.6-1.3-1.5-1.7-1.71.9-1.7-1.8-1.01.4
Bone: connectivity density0.30.50.70.8-0.70.7-0.70.60.60.70.7-0.80.70.70.80.1
Bone: cortical apparent density0.60.81.90.7-0.90.7-0.80.81.10.70.7-0.70.80.61.4-1.1
Bone: cortical area0.40.60.7-0.80.7-0.80.7-0.8-0.6-0.8-0.80.8-0.8-0.9-0.2-0.8
Bone: cortical porosity0.30.30.4-0.70.4-0.50.5-0.6-0.4-0.6-0.60.4-0.5-0.5-0.5-0.6
Bone: cortical porosity0.60.71.0-1.00.7-0.80.8-0.9-0.7-0.9-0.90.8-0.9-0.9-0.8-0.6
Bone: cortical thickness0.20.43.5-0.2-0.1-0.20.0-0.20.3-0.2-0.20.1-0.1-0.20.9-1.9
Bone: cortical thickness0.80.91.71.2-1.00.8-0.90.80.71.01.0-1.31.11.30.7-0.5
Bone: cortical tissue density0.40.61.40.6-0.80.6-0.70.70.90.70.7-0.60.70.51.2-0.9
Condit. Reinf. active minus inactive responses0.10.10.10.1-0.30.2-0.30.30.30.30.3-0.30.30.30.3-0.2
Condit. Reinf. active-inactive response ratio0.10.10.10.2-0.30.2-0.30.40.20.30.3-0.30.40.30.1-0.2
Condit. Reinf. active responses0.10.20.30.3-0.40.4-0.40.40.40.40.4-0.40.40.40.6-0.1
Condit. Reinf. inactive responses0.10.10.2-0.20.3-0.10.3-0.2-0.3-0.3-0.30.2-0.3-0.20.10.4
Incentive salience index mean0.60.81.10.9-1.10.8-1.00.91.00.90.9-0.90.90.80.7-0.6
Condit. Reinf. lever presses0.50.61.90.9-0.90.5-0.80.61.00.60.6-0.70.60.50.7-1.4
Condit. Reinf. active minus inactive responses1.51.83.6-1.51.3-1.11.3-1.1-1.0-1.4-1.41.9-1.5-1.8-1.30.3
Condit. Reinf. active-inactive response ratio1.21.32.3-1.21.1-1.01.1-1.0-0.9-1.2-1.21.5-1.3-1.5-1.10.0
Condit. Reinf. active responses0.60.91.9-1.00.9-0.80.9-0.7-0.6-1.0-1.01.4-1.0-1.3-0.6-0.8
Condit. Reinf. inactive responses0.10.11.70.00.0-0.20.1-0.10.00.00.00.00.1-0.00.2-1.3
Condit. Reinf. lever presses3.34.55.9-2.32.2-2.12.2-2.1-2.0-2.2-2.22.4-2.2-2.4-2.1-0.8
Condit. Reinf. lever reinforcers received0.91.22.5-1.21.0-1.01.1-0.9-0.7-1.1-1.11.6-1.2-1.5-0.8-0.7
Conditioned reinforcement - actives0.80.85.10.5-0.81.1-0.90.90.60.80.5-0.50.70.4-0.12.3
Conditioned reinforcement - inactives1.41.57.60.7-0.91.3-1.11.00.61.21.0-1.10.90.91.22.8
Conditioned locomotion1.41.72.71.2-1.51.5-1.41.51.71.51.2-1.01.20.81.50.5
Patch foraging indifference point 0 sec0.40.66.60.10.20.4-0.00.2-0.40.00.1-0.10.10.4-0.92.6
Patch foraging indifference point AUC1.41.62.21.3-1.41.3-1.41.41.51.51.4-1.21.21.10.90.0
Delay disc. indifference point, 0s delay0.70.82.3-0.80.5-0.90.6-0.8-0.3-0.9-0.90.5-0.8-0.91.4-1.5
Delay disc. indifference point, 16s delay2.12.16.21.4-1.51.2-1.41.31.51.41.3-1.51.41.22.5-0.7
Delay disc. indifference point, 2s delay1.01.13.6-0.80.7-1.20.8-1.1-0.5-1.1-1.10.8-1.2-1.20.4-1.9
Delay disc. indifference point, 24s delay4.14.07.42.1-2.01.7-2.01.91.92.12.0-2.22.02.12.7-0.6
Delay disc. indifference point, 4s delay1.01.12.4-0.90.8-1.10.9-1.1-0.6-1.1-1.10.8-1.2-1.10.5-1.5
Delay disc. indifference point, 8s delay1.61.66.81.2-1.20.9-1.11.01.31.11.1-1.31.01.02.6-1.0
Indifference point function ln k0.40.51.8-0.50.9-0.60.7-0.6-1.3-0.6-0.50.2-0.2-0.0-0.71.1
Indifference point function log k0.40.51.8-0.50.9-0.60.7-0.6-1.3-0.6-0.50.2-0.2-0.0-0.71.1
Patch foraging total patch changes 0 sec0.40.76.40.4-0.20.7-0.30.5-0.00.30.4-0.40.30.6-0.72.5
Patch foraging total patch changes 12 sec0.40.51.9-0.40.6-0.50.6-0.6-0.5-0.6-0.60.7-0.8-0.7-1.40.5
Patch foraging total patch changes 18 sec1.31.62.71.1-1.21.5-1.31.41.31.31.3-1.01.11.11.21.7
Patch foraging total patch changes 24 sec0.20.30.70.5-0.50.6-0.50.60.70.40.5-0.20.10.2-0.10.9
Patch foraging total patch changes 6 sec0.20.31.10.5-0.40.6-0.50.60.30.50.7-0.40.50.5-0.11.1
Patch foraging time to switch 0 sec1.93.03.7-1.91.7-1.91.8-1.9-1.4-1.8-1.81.9-1.9-1.8-1.2-1.4
Patch foraging water rate 0 sec2.74.35.22.2-2.22.2-2.22.21.92.12.1-2.32.02.11.91.2
Patch foraging water rate 12 sec4.46.78.32.8-2.72.7-2.72.82.82.62.6-2.62.62.52.90.4
Patch foraging water rate 18 sec6.68.911.83.4-3.03.3-3.13.12.52.93.0-3.33.13.22.02.4
Patch foraging water rate 24 sec2.94.05.22.0-2.02.3-2.12.11.81.91.9-2.11.81.91.92.0
Patch foraging water rate 6 sec4.56.58.22.8-2.52.5-2.62.62.12.72.7-2.92.82.82.51.1
Seeking ratio, delayed vs. immediate footshock0.50.50.9-0.90.8-0.60.8-0.7-1.0-0.8-0.70.7-0.7-0.4-0.80.1
Distance traveled before self-admin0.20.30.5-0.40.5-0.70.5-0.6-0.6-0.4-0.50.2-0.6-0.4-0.6-0.2
Distance traveled after self-admin0.70.71.40.8-1.00.6-0.90.71.10.60.6-0.90.50.61.1-1.2
Extensor digitorum longus weight0.31.43.0-1.21.4-1.31.3-1.3-1.7-1.1-1.10.9-0.9-0.8-1.40.0
Bone: elastic displacement0.20.20.5-0.40.4-0.40.5-0.5-0.3-0.5-0.50.5-0.5-0.6-0.2-0.7
Bone: elastic work2.63.34.0-1.91.7-1.91.9-1.9-1.6-1.9-1.92.0-1.8-2.0-1.2-2.0
Bone: endosteal estimation3.57.710.5-2.83.1-2.82.9-2.8-3.1-2.8-2.82.8-2.8-2.6-3.20.4
Bone: endosteal perimeter1.02.02.4-1.41.6-1.31.4-1.3-1.6-1.3-1.31.5-1.5-1.4-1.61.2
Epididymis fat weight9.021.026.9-4.95.0-5.04.9-5.0-5.2-5.0-4.74.3-4.5-4.3-3.9-1.6
Delta time in closed arm before/after self-admin0.40.40.90.4-0.50.7-0.50.70.40.70.9-0.40.70.80.90.3
Delta time in open arm before/after self-admin1.41.31.8-1.11.2-1.31.2-1.2-1.2-0.9-1.31.0-1.2-1.2-1.3-0.5
Diff in mean of infusions in LGA sessions0.30.30.60.7-0.50.3-0.50.50.50.70.6-0.60.60.70.2-0.6
Delay discount exponential model param1.01.16.8-0.80.8-0.30.7-0.4-0.9-0.6-0.50.8-0.5-0.5-2.61.6
Extinction: sum of active levers before priming0.20.21.70.20.2-0.00.1-0.0-0.50.20.2-0.30.20.4-1.30.8
Active lever presses in extinction session 61.81.82.4-1.31.5-1.21.3-1.3-1.5-1.2-1.31.2-1.3-1.3-1.51.3
Bone: final force0.91.41.9-1.21.2-1.31.2-1.2-1.0-1.2-1.21.4-1.2-1.2-1.0-1.2
Bone: final moment0.81.31.7-1.21.1-1.21.2-1.2-1.0-1.1-1.11.3-1.1-1.2-1.0-0.9
Food consumed during 24 hour testing period0.50.60.7-0.70.8-0.80.8-0.8-0.7-0.8-0.80.8-0.8-0.8-0.8-0.2
Glucose1.62.44.5-1.71.9-1.71.8-1.6-2.1-1.5-1.51.5-1.4-1.2-1.10.6
Heart weight3.44.88.6-2.02.1-2.02.1-2.1-1.8-2.5-2.32.3-2.5-2.3-2.90.0
Delay discount hyperbolic model param0.70.75.1-0.40.5-0.00.4-0.1-0.6-0.2-0.20.5-0.1-0.1-2.21.7
Intermittent access intake day 1-15 change1.21.21.7-1.31.0-0.61.0-0.8-0.8-1.3-1.31.2-1.0-1.3-0.71.3
Intermittent access intake escalation0.90.91.6-1.10.8-0.50.8-0.7-0.7-1.1-1.21.0-0.9-1.1-0.61.3
Intermittent access intake escalation 21.61.62.8-1.31.2-1.01.1-1.2-1.3-1.3-1.51.0-1.1-1.2-1.71.3
Intermitt. access day 1 inactive lever presses0.10.10.4-0.10.3-0.10.2-0.3-0.60.00.1-0.2-0.20.20.00.0
Intermitt. access day 15 inactive lever presses1.61.73.7-1.51.5-0.91.3-1.2-1.7-1.1-1.31.1-1.2-1.2-0.61.9
Intermitt. access escalation Index2.01.82.7-1.61.4-1.11.5-1.3-1.3-1.6-1.51.6-1.6-1.4-0.5-0.2
Intermittent access day 1 total infusions0.30.31.1-0.40.5-0.40.6-0.5-0.4-0.4-0.50.7-0.7-0.6-1.1-0.2
Intermittent access day 15 total infusions1.21.32.1-1.21.1-0.61.1-0.9-0.8-1.3-1.41.4-1.2-1.4-1.20.9
Intermittent access terminal intake (last 3 days)1.31.42.5-1.21.1-0.81.1-1.0-1.0-1.3-1.41.4-1.3-1.4-1.60.7
Intermittent access total infusions0.70.81.2-0.90.9-0.60.9-0.8-0.8-0.7-1.01.1-0.9-1.1-1.10.6
Intermittent access day 1 locomotion0.10.11.20.3-0.20.0-0.00.00.40.20.10.2-0.1-0.1-0.4-1.1
Intermittent access day 15 total locomotion0.00.00.2-0.10.10.10.1-0.00.20.0-0.30.3-0.2-0.5-0.20.2
Intermittent access total locomotion0.20.20.80.4-0.50.5-0.40.40.90.50.2-0.00.2-0.10.3-0.4
Intermittent access standard deviation0.20.21.80.1-0.00.2-0.10.1-0.2-0.0-0.1-0.20.30.2-0.81.4
Left kidney weight2.16.07.3-2.72.5-2.52.5-2.6-2.4-2.7-2.62.5-2.5-2.5-2.5-0.7
Right kidney weight1.95.47.0-2.62.4-2.42.4-2.4-2.2-2.5-2.42.4-2.4-2.4-2.4-0.6
Cocaine induced anxiety0.20.21.5-0.1-0.20.4-0.30.30.00.30.2-0.20.40.00.61.2
Post-drug Anxiety2.52.84.6-2.11.8-1.51.8-1.6-1.9-1.8-1.81.8-1.7-1.7-1.10.2
Baseline Anxiety3.84.15.9-2.02.3-2.22.2-2.2-2.4-2.2-2.11.8-2.1-1.5-2.0-0.7
Tail length1.03.07.5-1.51.9-1.71.7-1.7-2.3-1.5-1.61.3-1.5-1.2-2.71.3
Length with tail2.48.812.8-3.13.3-3.23.2-3.2-3.6-3.0-2.92.7-2.8-2.6-3.2-0.0
Length without tail1.83.95.0-2.22.1-2.12.1-2.2-1.9-2.2-2.11.9-2.0-2.1-1.2-1.1
Times rat made contact with spout4.04.66.9-2.12.1-2.02.1-2.1-1.9-2.3-2.32.3-2.4-2.3-2.6-0.3
Lifetime Intake0.20.30.7-0.60.4-0.10.4-0.3-0.4-0.3-0.50.7-0.5-0.7-0.40.9
Liver weight, left0.10.20.6-0.50.5-0.50.5-0.4-0.8-0.3-0.30.2-0.2-0.1-0.3-0.2
Liver weight, right0.20.41.8-0.40.6-0.60.6-0.6-0.8-0.3-0.30.4-0.2-0.1-1.3-0.6
Locomotor activity0.30.52.3-0.50.6-0.70.7-0.6-0.7-0.8-0.60.6-0.7-0.6-1.5-0.3
Locomotor testing distance0.10.20.30.5-0.50.5-0.50.50.40.40.5-0.50.40.40.30.2
Locomotor testing rearing0.00.00.10.0-0.30.2-0.30.20.40.20.1-0.2-0.0-0.10.30.1
Locomotion in novel chamber0.70.82.20.7-0.60.9-0.70.80.31.11.1-1.00.91.10.51.5
Locomotion in novel chamber post-restriction2.22.64.21.5-1.61.7-1.61.71.51.81.6-1.61.81.62.00.5
Fecal boli incidents, locomotor time 10.30.31.50.4-0.30.5-0.40.5-0.00.30.3-0.60.40.80.51.2
Change in fecal boli incidents, locomotor task0.20.20.40.4-0.40.4-0.40.40.50.60.6-0.30.50.30.20.1
Time >=10cm from walls, locomotor time 10.30.30.40.6-0.50.5-0.50.50.40.50.6-0.60.60.60.50.4
Bouts of movement, locomotor time 10.80.91.51.0-0.80.9-1.00.90.60.70.8-1.20.91.20.81.1
Total resting periods, locomotor time 11.21.42.31.3-1.01.2-1.21.10.71.01.0-1.51.21.50.71.5
Rest time, locomotor task time 10.40.51.60.7-0.40.6-0.40.50.20.40.4-0.50.40.9-1.31.1
Distance moved, locomotor task time 11.41.55.01.0-1.30.9-1.21.01.61.01.0-0.91.00.62.2-1.3
Vertical activity count, locomotor time 10.40.41.6-0.70.4-0.60.5-0.6-0.2-0.3-0.40.7-0.4-1.00.8-1.2
Time >=10cm from walls, locomotor time 21.92.02.5-1.61.6-1.61.6-1.6-1.6-1.5-1.41.5-1.4-1.5-0.8-0.4
Bouts of movement, locomotor time 20.40.40.8-0.50.5-0.60.5-0.7-0.5-0.8-0.70.6-0.8-0.6-0.9-0.7
Total resting periods, locomotor time 20.40.50.8-0.60.6-0.70.6-0.7-0.6-0.9-0.80.7-0.8-0.7-0.7-0.5
Rest time, locomotor task time 20.10.11.0-0.00.3-0.20.2-0.2-0.4-0.2-0.20.0-0.10.1-1.00.6
Distance moved, locomotor task time 21.41.64.31.1-1.31.1-1.31.21.41.31.3-1.11.21.02.1-0.5
Vertical activity count, locomotor time 20.20.31.10.4-0.50.2-0.40.30.60.50.4-0.10.40.10.8-1.1
Light reinforcement 10.20.33.7-0.10.10.1-0.0-0.1-0.1-0.1-0.2-0.1-0.3-0.2-0.11.9
Light reinforcement 20.20.33.7-0.30.20.20.1-0.1-0.4-0.1-0.3-0.0-0.1-0.20.21.9
Bone: marrow area3.57.610.5-2.83.0-2.82.9-2.8-3.1-2.7-2.72.8-2.8-2.6-3.20.5
Bone: maximum diameter1.52.83.5-1.91.8-1.61.7-1.7-1.8-1.8-1.81.7-1.9-1.8-1.60.5
Bone: maximum force0.61.01.5-1.21.0-1.11.1-1.0-0.9-1.0-1.01.2-0.9-1.0-0.7-0.9
Bone: maximum moment0.50.91.2-1.11.0-1.11.0-1.0-0.9-0.9-0.91.1-0.9-0.9-0.8-0.8
Mean time between licks in bursts0.60.81.70.8-0.90.8-0.90.80.90.90.9-0.90.91.01.3-0.0
Mean num. licks in bursts1.72.04.4-1.21.6-1.41.5-1.4-1.7-1.4-1.41.4-1.4-1.1-2.10.8
Cd content in liver0.40.41.4-0.60.6-0.70.7-0.6-0.5-0.6-0.60.7-0.5-0.6-0.6-1.2
Co content in liver0.80.91.31.1-1.11.1-1.11.01.20.80.8-0.90.90.90.9-0.3
Cu content in liver0.20.20.50.4-0.40.5-0.40.50.30.40.4-0.40.40.50.40.7
Fe content in liver0.40.40.9-0.80.6-0.50.6-0.5-0.3-0.8-0.80.9-0.7-0.9-0.4-0.6
K content in liver2.72.74.11.8-1.81.5-1.71.51.91.51.5-1.61.61.52.0-1.4
Mg content in liver0.80.82.10.7-0.90.7-0.80.81.10.70.7-0.60.70.71.4-1.4
Mn content in liver1.61.92.51.5-1.31.6-1.41.51.31.41.4-1.21.31.31.31.3
Na content in liver0.60.63.30.6-0.80.4-0.60.51.00.50.5-0.50.40.31.0-1.8
Rb content in liver0.30.43.10.0-0.2-0.1-0.10.10.10.30.3-0.20.40.50.9-1.8
Se content in liver0.10.10.80.10.0-0.30.1-0.2-0.1-0.1-0.1-0.1-0.0-0.10.1-0.9
Sr content in liver0.30.30.50.4-0.50.7-0.60.60.60.50.5-0.30.50.30.40.7
Zn content in liver0.30.30.60.4-0.70.5-0.60.50.80.40.4-0.40.50.30.7-0.4
Bone: minimum diameter0.91.62.5-1.41.3-1.31.3-1.3-1.2-1.4-1.41.5-1.4-1.6-0.8-0.2
Time in familiar zone, hab. session 10.10.11.00.1-0.0-0.30.0-0.20.00.00.0-0.1-0.00.0-0.3-1.0
Time in novel zone, hab. session 10.30.30.5-0.70.6-0.40.6-0.4-0.6-0.5-0.50.7-0.5-0.5-0.20.5
Total zone transitions, hab. session 10.81.11.51.2-1.01.2-1.11.10.91.01.0-1.21.01.10.71.0
Total locomotion distance, hab. session 11.52.12.61.6-1.41.5-1.51.61.31.51.5-1.51.51.61.01.1
Locomotion velocity, hab. session 12.23.13.71.9-1.81.9-1.91.91.71.81.8-1.91.81.81.41.1
Time in familiar zone, hab. session 20.40.40.70.5-0.60.7-0.60.70.60.70.7-0.60.70.60.20.9
Time in novel zone, hab. session 21.41.41.8-1.21.3-1.31.3-1.3-1.4-1.3-1.31.2-1.2-1.1-0.9-0.5
Total zone transitions, hab. session 20.10.11.30.00.10.2-0.00.1-0.0-0.1-0.10.1-0.1-0.20.11.2
Total locomotion distance, hab. session 20.50.73.90.6-0.61.0-0.70.90.40.70.7-0.50.70.60.12.0
Locomotion velocity, hab. session 21.11.43.91.1-1.11.5-1.11.41.01.11.1-0.91.21.00.62.0
Novel to familiar place preference ratio0.00.10.2-0.40.2-0.20.2-0.2-0.1-0.2-0.20.3-0.3-0.3-0.0-0.2
Novelty place preference0.00.00.2-0.30.1-0.20.1-0.1-0.0-0.1-0.10.2-0.2-0.2-0.0-0.5
Time in novel zone, NPP test0.30.30.6-0.80.5-0.50.5-0.5-0.5-0.6-0.60.6-0.6-0.6-0.5-0.5
Total zone transitions, NPP test0.70.91.41.0-1.01.2-1.01.11.10.90.9-0.80.90.71.10.9
Total locomotion distance, NPP test1.31.83.61.3-1.31.7-1.41.61.31.21.2-1.01.31.11.21.9
Locomotion velocity, NPP test1.92.74.11.6-1.62.0-1.71.91.71.61.6-1.31.61.41.51.9
Intraocular pressure0.40.61.80.7-0.30.7-0.50.7-0.10.60.7-0.70.91.20.41.4
Delta distance traveled before/after self-admin1.31.43.90.9-1.31.0-1.21.01.70.70.7-0.80.70.52.0-1.7
Delta ambulatory time before/after self-admin1.01.12.30.9-1.21.0-1.11.01.50.70.8-0.80.70.61.5-1.2
Parametrial fat weight16.331.838.3-5.96.1-6.26.1-6.2-6.1-5.8-6.05.5-5.6-5.5-4.6-2.4
Pavlov. Cond. lever latency2.12.73.5-1.91.8-1.41.7-1.5-1.7-1.6-1.61.8-1.7-1.6-1.81.4
Pavlov. Cond. magazine entry latency0.30.43.20.3-0.2-0.3-0.1-0.0-0.10.20.2-0.60.40.50.7-1.8
Pavlov. Cond. change in total contacts3.03.24.01.9-1.91.3-1.81.61.81.71.7-2.01.81.82.0-1.9
Pavlov. Cond. index score1.31.74.71.3-1.30.7-1.10.91.21.01.0-1.41.21.21.6-2.2
Pavlov. Cond. latency score2.22.84.01.8-1.81.2-1.61.41.71.51.5-1.81.61.62.0-1.9
Pavlov. Cond. lever contacts0.81.02.21.1-1.10.7-1.00.81.00.80.8-1.00.90.81.0-1.5
Pavlov. Cond. magazine entry number0.30.44.30.1-0.10.6-0.20.40.30.20.20.1-0.0-0.0-0.32.1
Pavlov. Cond. intertrial magazine entries0.81.08.30.4-0.51.1-0.70.90.50.70.7-0.30.60.60.22.9
Pavlov. Cond. lever-magazine prob. diff.1.31.66.01.2-1.20.6-1.10.81.21.01.0-1.31.11.11.6-2.4
Pavlov. Cond. response bias0.40.54.50.4-0.4-0.1-0.30.10.30.30.3-0.50.40.40.7-2.1
Pavlov. Cond. lever latency6.08.110.93.1-2.82.8-2.92.82.43.13.1-3.33.13.32.51.3
Pavlov. Cond. magazine entry latency3.64.25.6-2.42.3-1.92.2-2.0-2.3-2.1-2.12.2-2.0-2.0-1.90.8
Pavlov. Cond. change in total contacts5.67.710.6-3.02.7-2.72.8-2.7-2.3-3.0-3.03.3-3.0-3.3-2.4-1.5
Pavlov. Cond. index score6.78.611.0-3.33.0-2.93.0-2.9-2.7-3.1-3.13.3-3.1-3.3-2.5-0.9
Pavlov. Cond. latency score5.06.28.2-2.82.5-2.42.5-2.5-2.2-2.7-2.72.9-2.7-2.9-2.2-0.9
Pavlov. Cond. lever contacts5.17.09.6-2.92.6-2.62.7-2.6-2.2-2.8-2.83.1-2.9-3.1-2.1-1.4
Pavlov. Cond. magazine entry number4.96.08.02.8-2.62.4-2.62.42.52.62.6-2.82.52.62.1-0.0
Pavlov. Cond. intertrial magazine entries1.82.33.71.9-1.71.5-1.61.51.81.61.6-1.61.51.61.0-0.5
Pavlov. Cond. lever-magazine prob. diff.6.98.811.3-3.43.0-3.03.1-3.0-2.7-3.2-3.23.4-3.2-3.4-2.4-1.3
Pavlov. Cond. response bias6.08.210.8-3.33.0-2.83.0-2.8-2.7-3.0-3.03.3-3.0-3.2-2.4-0.6
Time in closed arm before self-admin0.10.10.9-0.20.20.00.2-0.1-0.3-0.2-0.20.2-0.2-0.0-0.20.9
Time in closed arm after self-admin0.60.72.80.5-0.61.1-0.60.90.50.60.8-0.30.60.70.71.7
Time in open arm before self-admin0.10.10.80.3-0.4-0.1-0.30.10.40.10.2-0.30.30.10.3-0.9
Time in open arm after self-admin0.80.92.7-0.80.7-1.20.8-1.0-0.6-0.7-1.00.7-0.9-1.1-0.5-1.6
Bone: periosteal estimation2.24.65.5-2.22.3-2.22.3-2.2-2.3-2.2-2.22.2-2.2-2.1-2.2-0.0
Bone: periosteal perimeter0.50.91.2-1.01.0-0.90.9-0.9-0.9-1.0-1.01.1-1.1-1.1-0.80.6
Bone: post-yield work0.00.10.2-0.30.3-0.30.3-0.2-0.3-0.1-0.10.2-0.1-0.0-0.10.4
Progressive ratio test 1 active lever presses0.20.20.6-0.30.2-0.10.3-0.2-0.0-0.4-0.40.6-0.6-0.6-0.80.1
Progressive ratio test 1 breakpoint0.30.40.9-0.50.4-0.30.5-0.4-0.2-0.6-0.70.8-0.8-0.8-0.9-0.2
Progressive ratio test 1 inactive lever presses0.20.22.0-0.50.4-0.00.3-0.2-0.60.2-0.10.3-0.2-0.3-0.41.4
Progressive ratio test 2 active lever presses0.10.20.4-0.30.2-0.10.2-0.20.0-0.2-0.50.6-0.5-0.7-0.60.3
Progressive ratio test 2 breakpoint0.10.20.4-0.40.3-0.20.3-0.3-0.1-0.2-0.50.6-0.5-0.6-0.50.0
Progressive ratio test 2 inactive lever presses1.21.32.4-1.21.2-0.71.0-1.0-1.3-1.0-1.31.1-1.1-1.1-1.31.6
Incentive Sensitization - Responses0.00.00.2-0.0-0.10.2-0.10.00.20.30.20.2-0.0-0.10.30.5
Incentive Sensitization - Breakpoint0.10.10.3-0.1-0.00.2-0.00.00.20.20.10.3-0.1-0.30.20.6
Sum of active levers in priming session hrs 5-61.00.91.80.7-0.70.9-0.80.90.41.11.1-1.11.01.01.11.4
Progressive ratio1.82.13.01.3-1.41.7-1.51.61.31.51.4-1.41.41.41.41.3
Food seeking constrained by brief footshock3.44.27.62.1-2.42.2-2.32.22.72.01.9-2.01.71.52.1-0.1
Seeking ratio, punishment vs. effort0.50.62.6-0.50.4-0.90.6-0.70.0-0.8-0.70.7-0.8-1.0-0.4-1.6
Retroperitoneal fat weight18.059.371.9-8.08.2-8.58.2-8.4-8.1-8.2-8.07.4-7.8-7.3-6.6-4.5
Reaction time number correct0.60.91.40.9-0.81.0-0.90.90.50.70.8-1.21.11.10.91.1
Reaction time mean minus median2.43.24.1-2.02.0-2.01.9-1.9-2.0-1.8-1.71.7-1.8-1.8-1.50.1
Reaction time mean minus median AUC2.33.04.1-1.92.0-1.91.9-1.9-2.0-1.8-1.71.6-1.7-1.7-1.50.3
Reaction time num false alarms1.41.82.71.6-1.41.6-1.41.51.31.31.3-1.31.31.30.51.4
Reaction time num false alarms AUC1.31.82.51.5-1.41.6-1.41.51.41.31.3-1.21.31.20.81.2
Reaction time trials correct on left0.60.91.40.9-0.81.0-0.90.90.50.70.8-1.21.11.10.91.1
Reaction time trials on left0.60.81.30.9-0.71.0-0.90.90.50.70.8-1.21.01.10.81.1
Reaction time mean4.46.27.6-2.82.7-2.62.7-2.7-2.5-2.6-2.52.7-2.6-2.7-2.0-0.4
Reaction time mean AUC3.85.16.1-2.42.5-2.42.4-2.5-2.3-2.3-2.32.4-2.4-2.4-1.8-0.4
Median of all reaction times3.95.36.6-2.62.4-2.32.4-2.5-2.2-2.4-2.42.6-2.5-2.5-1.8-0.5
Reaction time omissions0.70.91.4-1.11.1-1.11.0-1.1-1.2-1.1-0.90.8-0.9-0.7-0.8-0.0
Reaction time false alarm rate0.50.61.10.9-0.91.0-0.90.91.00.80.8-0.60.70.60.40.7
Reaction time premature initiation rate0.20.31.70.10.2-0.00.1-0.1-0.1-0.1-0.20.1-0.4-0.2-1.21.3
Reaction time premature initiations0.30.53.40.7-0.20.5-0.40.40.10.40.3-0.60.20.5-0.81.8
Std. dev. reaction times2.94.15.4-2.32.3-2.32.2-2.2-2.2-2.0-2.02.1-2.0-2.1-1.3-0.3
Reaction time trials completed0.60.81.30.9-0.71.0-0.90.90.50.70.8-1.21.01.10.81.1
Reaction time trials AUC0.50.71.60.7-0.60.8-0.70.80.30.60.7-1.00.91.00.81.3
Run reversals in cocaine runway, females2.12.03.1-1.71.3-1.41.4-1.4-1.1-1.6-1.71.6-1.6-1.80.2-1.0
Run reversals in cocaine runway, males1.91.93.3-1.11.1-1.31.2-1.2-0.5-1.2-1.41.6-1.5-1.8-1.8-1.5
Latency to leave start box in cocaine runway0.20.20.60.3-0.10.3-0.10.3-0.20.40.7-0.30.50.8-0.10.7
Latency to leave start box in cocaine runway, F0.50.51.2-0.80.9-0.60.9-0.7-1.1-0.5-0.40.7-0.5-0.5-0.60.7
Latency to leave start box in cocaine runway, M1.91.82.61.6-1.41.3-1.41.41.31.61.5-1.41.51.60.60.1
Std. dev. time between licks in bursts1.11.31.61.2-1.21.1-1.21.21.11.11.1-1.31.21.11.20.2
Total sessions with >9 infusions0.30.31.2-0.50.2-0.10.3-0.20.2-0.4-0.51.0-0.7-1.1-0.80.2
Short access day 1 total inactive lever presses0.50.64.70.10.00.5-0.10.3-0.40.90.6-0.30.60.50.82.2
Short access day 10 total inactive lever presses0.70.72.7-0.91.2-1.01.1-1.1-1.6-0.4-0.60.4-0.6-0.4-0.50.4
Short access day 1 total infusions0.70.82.30.6-0.71.1-0.70.90.71.11.0-0.40.80.50.61.5
Short access day 10 total infusions0.10.10.5-0.40.20.00.3-0.1-0.0-0.3-0.40.7-0.5-0.6-0.40.3
Short access total infusions0.10.10.4-0.40.10.10.2-0.00.1-0.0-0.10.5-0.2-0.60.60.4
Short access day 1 locomotion0.10.20.4-0.1-0.20.4-0.10.30.6-0.1-0.40.5-0.3-0.7-0.60.3
Short access day 10 total locomotion0.30.40.80.7-0.80.9-0.70.70.90.50.4-0.40.60.30.00.1
Short access total locomotion0.40.41.60.7-0.80.7-0.70.71.30.50.3-0.20.2-0.00.3-0.6
One hour access (0.3 mA shock)1.01.12.60.8-1.01.2-1.11.11.01.00.9-0.81.10.71.61.2
Compulsive drug intake2.82.84.61.5-1.41.5-1.51.61.01.92.1-1.92.02.11.71.0
One hour access (shock baseline)0.50.61.3-0.60.6-0.60.6-0.6-0.4-0.7-1.11.0-0.8-1.0-1.10.0
Social response proportion5.15.57.7-2.02.6-2.72.6-2.6-2.7-2.4-2.22.1-2.2-1.8-2.8-1.5
Social responses0.70.91.3-0.70.9-0.90.9-1.0-0.8-1.1-1.01.0-1.1-0.9-1.1-0.6
Social time1.82.33.1-1.31.4-1.61.5-1.6-1.4-1.7-1.61.4-1.7-1.4-1.8-1.4
Soleus weight0.10.40.9-0.60.8-0.70.7-0.7-0.9-0.6-0.60.5-0.5-0.4-0.7-0.2
Bone: stiffness0.20.40.6-0.70.6-0.60.6-0.6-0.5-0.6-0.60.7-0.5-0.6-0.7-0.2
Tibialis anterior weight1.13.94.9-2.02.1-2.22.1-2.1-2.2-2.0-2.01.8-1.8-1.8-2.0-1.1
Time to tail flick, vehicle, before self-admin3.33.48.0-2.22.2-1.92.0-1.9-2.8-1.7-1.51.4-1.5-1.1-1.71.3
Time to tail flick, vehicle, after self-admin0.00.00.20.10.0-0.0-0.00.0-0.30.30.2-0.20.30.20.40.1
Time to tail flick, test, before self-admin0.30.31.00.5-0.40.3-0.40.50.20.70.6-0.60.70.60.21.0
Time to tail flick, test, after self-admin0.60.67.1-0.30.20.30.00.1-0.60.20.1-0.20.30.10.52.7
Delta time to tail flick, vehicle, before/after SA1.41.42.11.3-1.31.2-1.21.31.51.41.1-1.01.20.81.3-0.1
Delta time to tail flick, test, before/after SA0.20.21.4-0.40.20.10.2-0.1-0.4-0.2-0.20.1-0.1-0.20.11.2
Tibia length3.710.412.2-3.23.4-3.43.4-3.5-3.2-3.5-3.53.3-3.4-3.4-2.9-1.0
Ambulatory time before self-admin0.40.40.7-0.80.7-0.70.6-0.8-0.7-0.7-0.80.5-0.8-0.9-0.1-0.1
Ambulatory time after self-admin0.80.91.90.9-1.10.8-1.00.81.40.70.7-0.90.50.51.3-1.2
Bone: tissue strength1.11.11.9-1.00.9-1.01.0-0.9-0.5-1.1-1.11.4-1.2-1.4-0.8-1.0
Total heroin consumption0.40.53.30.4-0.10.4-0.30.4-0.40.70.7-0.80.60.8-0.41.8
Bone: trabecular number0.40.60.80.9-0.70.7-0.70.70.70.80.8-0.80.80.90.8-0.1
Bone: trabecular spacing1.82.33.1-1.71.5-1.51.6-1.5-1.3-1.7-1.71.8-1.7-1.7-1.3-0.9
Bone: trabecular thickness0.10.10.40.3-0.20.1-0.30.0-0.10.30.3-0.70.40.50.4-0.2
Bone: trabecular tissue density0.30.42.1-0.60.2-0.40.3-0.40.2-0.5-0.50.6-0.5-0.80.1-1.5
Water consumed over 24 hours0.70.81.9-0.80.9-0.60.8-0.7-1.0-0.8-0.80.8-0.9-0.8-1.41.2
Number of responses in last shaping day0.50.54.00.4-0.50.8-0.60.60.50.60.4-0.40.40.20.22.0