Dstn

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	Dstn	0.02	0.02	3.0e-04	0.02	0.02	0.01	0.02	7.9e-04	1.2e-04	3.2e-03	1.5e-03
2	PL	mRNA stability	Dstn	0.02	0.02	5.8e-03	0.03	0.02	0.02	0	7.1e-04	5.7e-03	1.1e-03	3.5e-01
3	Adipose	gene expression	Dstn	0.08	0.05	3.7e-07	0.02	0.03	0.02	0.02	2.1e-03	6.9e-04	1.8e-03	2.1e-03
4	IL	mRNA stability	Dstn	0.18	0.13	7.6e-03	0	0.01	0	0.04	2.6e-01	1.6e-01	2.7e-01	5.0e-02
5	Adipose	isoform ratio	XR_010064687.1	0.03	0.03	9.4e-03	0.01	0.01	0	0.01	1.7e-02	4.0e-02	7.9e-02	2.8e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.2	0.3	0.9	-0.3	0.5	0.3	-0.7	0.9
Area under the delay curve	1.7	2.6	5.0	-0.5	0.8	1.7	-2.1	2.2
BMI with tail	5.8	20.1	44.0	6.6	-6.4	3.9	0.5	-0.6
BMI without tail	3.0	15.8	34.2	5.9	-5.8	3.3	0.5	-0.1
Body weight	7.2	31.6	71.0	8.4	-8.2	3.6	1.8	-2.0
Weight adjusted by age	0.1	0.2	0.4	0.2	-0.4	-0.3	0.6	-0.6
Bone surface	0.1	0.2	0.5	0.7	-0.6	0.1	0.4	0.3
Bone volume	0.0	0.1	0.2	0.4	-0.2	-0.1	0.4	0.1
Breakpoint value in progressive ratio session	0.1	0.1	0.2	0.5	-0.3	0.0	0.3	-0.4
Number of licking bursts	0.1	0.4	0.7	-0.0	0.0	0.8	-0.9	0.8
Context. condit. distance diff. score	0.1	0.1	0.4	-0.1	0.0	-0.2	-0.0	-0.6
Locomotion velocity, session 1	1.1	1.3	2.7	-1.0	0.9	-1.7	1.2	-0.6
Locomotion distance, session 1	2.3	3.0	6.2	-2.5	2.4	-1.8	0.2	0.2
Locomotion velocity, session 2	1.0	1.2	2.4	-1.6	1.5	-0.5	-0.6	1.0
Locomotion distance, session 2	3.3	4.6	7.7	-2.8	2.5	-2.7	1.0	-0.7
Locomotion velocity, session 3	1.9	2.2	4.9	-2.2	2.2	-1.0	-0.4	0.4
Locomotion distance, session 3	0.8	0.9	1.9	-1.4	1.4	-0.2	-0.6	0.6
Stereotopy head waving bouts, day 3	0.2	0.2	0.4	0.1	-0.0	-0.6	0.6	-0.6
Stereotopy head waving duration, day 3	0.2	0.2	0.4	0.3	-0.3	-0.4	0.7	-0.6
Locomotion velocity, session 7	1.0	1.1	2.5	-1.0	0.8	-1.6	1.1	-0.7
Locomotion distance, session 7	1.0	1.3	2.7	-0.2	-0.1	-1.7	1.6	-1.0
Stereotopy head waving bouts, day 7	0.2	0.2	0.4	0.5	-0.4	0.6	-0.3	-0.2
Stereotopy head waving duration, day 7	0.1	0.1	0.3	-0.2	0.4	0.4	-0.5	0.1
Locomotion velocity, session 8	1.1	1.4	2.6	-0.9	0.9	-1.6	1.0	-1.3
Locomotion distance, session 8	1.9	2.8	4.8	-2.1	1.8	-2.2	0.8	-1.2
Degree of sensitization distance	2.0	2.1	3.9	1.3	-1.4	-1.1	2.0	-1.4
Degree of sensitization stereotypy	0.3	0.3	0.6	0.7	-0.6	0.8	-0.4	-0.1
Conditioned locomotion	0.5	0.6	1.6	0.1	-0.1	-1.1	1.3	-0.5
Cocaine response after cond. corrected	1.0	1.5	3.0	-1.4	1.0	-1.7	0.8	-0.9
Cocaine response after cond. not corrected	1.4	2.1	3.4	-1.8	1.6	-1.8	0.5	-1.0
Cocaine response before conditioning	0.2	0.3	0.6	-0.4	0.7	0.2	-0.8	-0.3
Saline control response	3.4	4.8	9.0	1.1	-1.4	-2.0	2.8	-3.0
Bone: connectivity density	0.3	0.5	0.9	-0.7	0.7	0.1	-0.6	0.9
Bone: cortical apparent density	0.9	1.4	2.6	-0.8	1.1	0.8	-1.6	1.4
Bone: cortical area	0.2	0.3	0.6	0.6	-0.5	0.7	-0.5	0.3
Bone: cortical porosity	0.3	0.4	0.6	0.4	-0.5	0.8	-0.8	0.5
Bone: cortical porosity	0.3	0.4	0.7	0.7	-0.8	0.7	-0.3	0.2
Bone: cortical thickness	1.2	2.0	4.7	0.1	0.1	1.8	-2.2	1.4
Bone: cortical thickness	0.9	1.1	2.0	-0.7	0.9	0.7	-1.4	1.2
Bone: cortical tissue density	0.7	1.1	2.1	-0.8	1.1	0.6	-1.4	1.2
Condit. Reinf. active minus inactive responses	0.1	0.1	0.1	-0.2	0.3	0.2	-0.4	-0.3
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.3	-0.2	0.4	0.3	-0.5	-0.1
Condit. Reinf. active responses	0.1	0.1	0.2	-0.4	0.4	0.0	-0.3	0.0
Condit. Reinf. inactive responses	0.2	0.3	0.7	0.1	-0.3	-0.6	0.8	-0.4
Incentive salience index mean	0.8	1.1	1.7	-0.8	0.9	0.7	-1.3	1.3
Condit. Reinf. lever presses	2.0	3.0	7.7	-0.6	0.7	1.6	-2.0	2.8
Condit. Reinf. active minus inactive responses	0.9	1.5	2.5	1.2	-1.6	-0.5	1.2	-1.3
Condit. Reinf. active-inactive response ratio	0.5	0.7	1.7	1.0	-1.3	-0.1	0.7	-0.6
Condit. Reinf. active responses	0.3	0.5	1.2	1.0	-1.1	0.5	-0.1	-0.1
Condit. Reinf. inactive responses	0.5	0.8	1.5	0.3	-0.0	1.2	-1.2	0.9
Condit. Reinf. lever presses	1.6	2.3	5.4	2.2	-2.3	0.5	0.8	-0.7
Condit. Reinf. lever reinforcers received	0.4	0.6	1.4	1.1	-1.2	0.4	0.1	-0.3
Conditioned reinforcement - actives	1.2	4.7	9.9	-1.1	0.7	-3.1	2.4	-2.5
Conditioned reinforcement - inactives	1.9	5.3	10.4	-1.2	0.9	-3.2	2.6	-2.6
Conditioned locomotion	0.7	1.0	2.2	-1.4	1.5	-0.8	-0.5	0.3
Patch foraging indifference point 0 sec	1.4	3.8	6.4	-0.3	0.0	-2.5	2.5	-2.5
Patch foraging indifference point AUC	0.7	1.8	2.5	-1.5	1.6	0.3	-1.4	1.5
Delay disc. indifference point, 0s delay	1.8	2.0	3.7	0.5	-0.4	1.9	-1.7	1.8
Delay disc. indifference point, 16s delay	1.3	1.9	2.6	-1.3	1.5	0.7	-1.6	1.6
Delay disc. indifference point, 2s delay	1.9	2.1	4.1	1.0	-0.8	2.0	-1.3	1.7
Delay disc. indifference point, 24s delay	1.4	2.2	4.1	-1.8	2.0	0.2	-1.4	1.4
Delay disc. indifference point, 4s delay	1.7	1.8	3.5	0.8	-0.7	1.9	-1.3	1.6
Delay disc. indifference point, 8s delay	0.9	1.5	2.4	-0.9	1.0	0.8	-1.5	1.5
Indifference point function ln k	0.5	1.5	3.3	0.7	-0.8	-1.0	1.8	-1.5
Indifference point function log k	0.5	1.5	3.3	0.7	-0.8	-1.0	1.8	-1.5
Patch foraging total patch changes 0 sec	1.2	3.4	6.3	-0.6	0.3	-2.5	2.2	-2.3
Patch foraging total patch changes 12 sec	0.1	0.2	0.3	0.4	-0.6	-0.3	0.6	-0.3
Patch foraging total patch changes 18 sec	0.7	1.6	2.7	-1.5	1.3	-1.6	0.6	-0.9
Patch foraging total patch changes 24 sec	0.1	0.3	0.6	-0.6	0.5	-0.8	0.4	-0.2
Patch foraging total patch changes 6 sec	0.4	0.7	1.3	-0.7	0.6	-1.1	0.7	-0.9
Patch foraging time to switch 0 sec	0.5	1.9	3.6	1.9	-1.9	1.5	-0.3	-0.2
Patch foraging water rate 0 sec	0.6	2.3	5.0	-2.2	2.2	-1.2	-0.3	0.4
Patch foraging water rate 12 sec	0.9	3.6	6.8	-2.6	2.6	-0.4	-1.4	1.4
Patch foraging water rate 18 sec	2.3	5.2	10.7	-3.3	3.0	-2.5	0.4	-0.1
Patch foraging water rate 24 sec	2.0	2.8	5.4	-2.3	1.9	-2.1	0.5	-0.6
Patch foraging water rate 6 sec	2.2	3.2	7.4	-2.6	2.7	-1.3	-0.4	0.3
Seeking ratio, delayed vs. immediate footshock	0.6	0.8	1.2	0.8	-0.9	-0.5	1.1	-1.1
Distance traveled before self-admin	0.3	0.6	1.2	0.7	-0.7	1.1	-0.8	0.5
Distance traveled after self-admin	0.9	1.7	3.3	-0.9	0.7	1.0	-1.8	1.6
Extensor digitorum longus weight	0.2	0.7	1.3	1.1	-0.9	-0.1	0.8	-0.7
Bone: elastic displacement	0.3	0.4	0.6	0.6	-0.6	0.7	-0.3	0.8
Bone: elastic work	1.9	2.5	4.0	2.0	-1.9	1.9	-0.8	0.9
Bone: endosteal estimation	2.0	4.9	7.6	2.8	-2.7	-0.5	2.6	-1.7
Bone: endosteal perimeter	1.1	2.8	5.6	1.1	-1.3	-1.3	2.4	-1.9
Epididymis fat weight	4.3	21.5	46.8	6.7	-6.8	2.6	2.0	-2.2
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	-0.4	0.4	-0.3	0.2	-0.1
Delta time in open arm before/after self-admin	0.6	0.7	1.8	1.4	-1.1	0.7	0.1	-0.1
Diff in mean of infusions in LGA sessions	0.9	1.6	2.8	0.1	0.3	1.6	-1.7	1.6
Delay discount exponential model param	1.8	2.4	4.6	0.7	-0.9	-1.5	2.0	-2.1
Extinction: sum of active levers before priming	0.2	0.3	0.5	-0.4	0.6	-0.7	0.6	-0.6
Active lever presses in extinction session 6	1.1	1.1	1.8	1.3	-1.3	-0.1	1.0	-1.0
Bone: final force	0.3	0.5	1.1	1.1	-0.8	0.8	-0.2	-0.1
Bone: final moment	0.3	0.4	1.0	1.0	-0.8	0.7	-0.1	0.0
Food consumed during 24 hour testing period	0.1	0.2	0.5	0.7	-0.7	0.2	0.2	-0.0
Glucose	1.7	2.6	4.2	1.7	-1.6	-0.5	1.8	-2.0
Heart weight	1.5	2.4	5.2	1.8	-2.3	-0.0	1.4	-1.3
Delay discount hyperbolic model param	1.6	2.1	4.1	0.3	-0.5	-1.6	1.8	-2.0
Intermittent access intake day 1-15 change	0.3	1.7	2.2	1.0	-1.5	-0.9	1.5	-1.5
Intermittent access intake escalation	0.2	1.3	1.9	0.8	-1.2	-0.9	1.4	-1.4
Intermittent access intake escalation 2	0.5	0.9	1.5	1.0	-1.2	-0.4	1.0	-1.0
Intermitt. access day 1 inactive lever presses	0.1	1.1	2.1	0.1	0.2	-1.1	1.4	-1.4
Intermitt. access day 15 inactive lever presses	1.0	5.6	10.3	0.6	-0.7	-2.6	3.2	-3.2
Intermitt. access escalation Index	0.1	0.5	1.0	0.8	-1.0	0.8	-0.3	0.2
Intermittent access day 1 total infusions	0.0	0.1	0.1	0.4	-0.3	-0.1	0.4	-0.3
Intermittent access day 15 total infusions	0.8	1.8	2.6	1.1	-1.5	-0.9	1.6	-1.6
Intermittent access terminal intake (last 3 days)	1.0	1.8	2.5	1.3	-1.6	-0.6	1.5	-1.5
Intermittent access total infusions	0.8	0.9	1.5	0.8	-0.8	-0.7	1.2	-1.2
Intermittent access day 1 locomotion	0.3	0.6	1.0	-0.4	0.6	0.6	-1.0	1.0
Intermittent access day 15 total locomotion	0.0	0.1	0.1	0.1	-0.3	-0.4	0.2	-0.3
Intermittent access total locomotion	0.2	0.2	0.4	-0.6	0.6	-0.1	-0.5	0.4
Intermittent access standard deviation	0.1	0.4	0.9	-0.3	0.2	-1.0	0.7	-0.8
Left kidney weight	0.5	3.8	8.4	2.9	-2.8	0.9	0.8	-1.0
Right kidney weight	0.2	1.5	2.9	1.6	-1.7	0.2	0.9	-1.1
Cocaine induced anxiety	0.1	0.3	0.4	-0.4	0.5	-0.7	0.5	-0.5
Post-drug Anxiety	0.5	0.6	1.4	1.2	-1.0	0.4	0.5	-0.5
Baseline Anxiety	1.5	2.5	5.2	2.3	-2.2	1.7	-0.2	0.2
Tail length	0.3	1.5	3.3	1.8	-1.8	0.3	0.8	-0.4
Length with tail	1.8	7.9	15.6	3.9	-3.9	0.4	2.0	-2.1
Length without tail	0.9	5.0	9.9	3.1	-3.0	0.6	1.3	-1.9
Times rat made contact with spout	1.9	2.2	5.3	2.1	-2.3	0.3	1.1	-0.3
Lifetime Intake	0.5	0.7	1.2	0.4	-0.5	-0.8	1.1	-1.1
Liver weight, left	1.6	2.8	5.3	2.3	-2.3	0.3	1.3	-1.3
Liver weight, right	1.7	2.9	6.4	2.5	-2.3	0.5	1.2	-1.1
Locomotor activity	0.1	0.2	0.7	0.6	-0.8	0.3	0.0	-0.1
Locomotor testing distance	0.1	0.1	0.3	-0.5	0.3	-0.0	-0.6	0.2
Locomotor testing rearing	0.0	0.1	0.5	-0.3	0.0	0.0	-0.7	-0.0
Locomotion in novel chamber	1.1	1.4	3.0	-1.3	1.7	-1.3	0.6	-0.6
Locomotion in novel chamber post-restriction	0.6	1.8	4.4	-1.8	2.1	-1.0	-0.2	0.1
Fecal boli incidents, locomotor time 1	0.5	1.3	2.2	-0.5	0.4	-1.5	1.4	-1.3
Change in fecal boli incidents, locomotor task	0.1	0.1	0.4	-0.5	0.6	-0.3	0.0	0.2
Time >=10cm from walls, locomotor time 1	0.1	0.2	0.4	-0.6	0.6	-0.4	0.0	-0.1
Bouts of movement, locomotor time 1	0.4	0.6	1.0	-1.0	0.8	-1.0	0.4	-0.5
Total resting periods, locomotor time 1	1.0	1.1	2.0	-1.2	1.0	-1.4	0.7	-0.8
Rest time, locomotor task time 1	0.8	1.3	2.2	-0.4	0.0	-1.5	1.4	-1.5
Distance moved, locomotor task time 1	1.0	2.8	5.0	-1.0	1.2	1.3	-2.2	2.2
Vertical activity count, locomotor time 1	0.1	0.9	1.6	0.5	-0.2	1.3	-1.2	1.0
Time >=10cm from walls, locomotor time 2	0.4	1.1	2.4	1.5	-1.4	0.4	0.7	-0.7
Bouts of movement, locomotor time 2	0.1	0.2	0.4	0.4	-0.6	0.5	-0.5	0.3
Total resting periods, locomotor time 2	0.0	0.2	0.5	0.5	-0.7	0.4	-0.2	-0.0
Rest time, locomotor task time 2	0.2	0.4	0.6	0.1	-0.3	-0.6	0.8	-0.8
Distance moved, locomotor task time 2	1.0	1.3	1.8	-1.0	1.2	0.6	-1.4	1.4
Vertical activity count, locomotor time 2	0.3	0.8	1.6	-0.2	0.5	0.9	-1.3	1.1
Light reinforcement 1	0.3	1.2	2.2	-0.2	-0.2	-1.5	1.5	-1.2
Light reinforcement 2	1.0	2.3	4.2	-0.2	-0.1	-1.9	2.0	-1.8
Bone: marrow area	2.0	4.9	7.4	2.7	-2.7	-0.5	2.6	-1.7
Bone: maximum diameter	0.9	1.9	2.7	1.5	-1.6	-0.5	1.6	-1.4
Bone: maximum force	0.2	0.4	0.8	0.9	-0.6	0.7	-0.3	-0.3
Bone: maximum moment	0.2	0.3	0.7	0.8	-0.6	0.7	-0.3	-0.1
Mean time between licks in bursts	0.1	0.4	0.8	-0.8	0.9	0.1	-0.8	-0.4
Mean num. licks in bursts	0.6	1.5	2.9	1.3	-1.4	-0.7	1.7	-0.9
Cd content in liver	0.1	0.1	0.2	0.4	-0.2	0.4	0.0	0.4
Co content in liver	0.3	0.3	0.8	-0.5	0.4	-0.9	0.4	-0.3
Cu content in liver	0.1	0.2	0.3	-0.4	0.4	-0.6	0.2	-0.2
Fe content in liver	0.8	1.0	1.7	1.2	-1.1	1.3	-0.8	0.1
K content in liver	3.1	3.1	5.1	-1.4	1.7	1.1	-2.3	2.0
Mg content in liver	0.3	0.3	0.9	-0.2	0.3	0.6	-0.9	0.3
Mn content in liver	1.3	1.5	3.0	-1.1	0.9	-1.7	1.3	-0.8
Na content in liver	1.4	1.5	3.8	-0.2	0.3	1.5	-2.0	1.3
Rb content in liver	0.4	0.4	0.9	0.7	-0.4	0.9	-0.8	0.1
Se content in liver	0.5	0.6	1.1	0.7	-0.6	1.0	-0.8	0.8
Sr content in liver	0.6	0.5	1.0	-0.8	0.6	-1.0	0.5	-0.5
Zn content in liver	0.5	0.6	1.3	-0.6	0.6	0.5	-1.1	0.8
Bone: minimum diameter	0.3	0.5	1.2	1.1	-1.1	0.2	0.4	-0.4
Time in familiar zone, hab. session 1	0.9	1.0	2.5	0.2	0.1	1.2	-1.1	1.6
Time in novel zone, hab. session 1	0.8	0.9	2.4	0.4	-0.6	-0.7	1.0	-1.6
Total zone transitions, hab. session 1	0.5	0.7	1.3	-1.1	1.0	-0.9	0.3	0.1
Total locomotion distance, hab. session 1	0.8	1.1	2.3	-1.5	1.5	-1.1	0.2	-0.1
Locomotion velocity, hab. session 1	1.1	1.6	3.6	-1.9	1.8	-1.1	-0.2	0.3
Time in familiar zone, hab. session 2	0.3	0.3	0.4	-0.7	0.6	-0.6	0.3	-0.6
Time in novel zone, hab. session 2	0.6	0.7	1.5	1.2	-1.2	0.3	0.5	-0.2
Total zone transitions, hab. session 2	0.6	0.8	1.3	-0.2	-0.0	-1.1	1.1	-1.1
Total locomotion distance, hab. session 2	1.6	2.1	4.1	-0.9	0.7	-2.0	1.5	-1.6
Locomotion velocity, hab. session 2	1.5	2.0	4.0	-1.3	1.2	-2.0	1.2	-1.2
Novel to familiar place preference ratio	0.0	0.0	0.0	0.1	-0.1	0.1	-0.1	-0.1
Novelty place preference	0.0	0.1	0.1	0.1	-0.1	0.3	-0.4	0.2
Time in novel zone, NPP test	0.1	0.1	0.3	0.5	-0.5	0.4	-0.1	-0.1
Total zone transitions, NPP test	0.5	0.7	1.2	-1.1	0.9	-1.0	0.3	-0.6
Total locomotion distance, NPP test	1.7	2.3	4.3	-1.5	1.3	-2.1	1.2	-1.4
Locomotion velocity, NPP test	1.7	2.4	4.2	-1.9	1.6	-2.1	0.9	-1.0
Intraocular pressure	0.7	1.1	1.7	-0.5	0.5	-1.3	1.3	-1.2
Delta distance traveled before/after self-admin	1.7	1.9	2.6	-1.6	1.4	0.3	-1.5	1.6
Delta ambulatory time before/after self-admin	0.8	1.3	2.0	-1.4	1.2	0.1	-1.2	1.3
Parametrial fat weight	12.2	28.7	66.0	8.1	-7.7	3.3	2.0	-2.1
Pavlov. Cond. lever latency	4.0	5.0	10.4	1.5	-1.7	-1.6	2.7	-3.2
Pavlov. Cond. magazine entry latency	1.4	1.8	3.3	0.3	-0.1	1.8	-1.7	1.7
Pavlov. Cond. change in total contacts	5.2	5.6	9.9	-1.4	1.7	2.0	-3.1	3.0
Pavlov. Cond. index score	4.1	5.2	10.4	-0.8	1.1	2.2	-3.0	3.2
Pavlov. Cond. latency score	4.6	5.8	11.6	-1.3	1.5	2.0	-3.0	3.4
Pavlov. Cond. lever contacts	3.0	3.6	8.4	-0.8	0.9	1.7	-2.3	2.9
Pavlov. Cond. magazine entry number	1.9	2.4	4.2	-0.3	0.0	-2.1	2.0	-1.9
Pavlov. Cond. intertrial magazine entries	4.4	5.2	9.1	-1.0	0.5	-3.0	2.6	-3.0
Pavlov. Cond. lever-magazine prob. diff.	4.9	6.0	11.7	-0.7	1.0	2.6	-3.2	3.4
Pavlov. Cond. response bias	2.6	3.3	5.8	0.1	0.2	2.3	-2.3	2.4
Pavlov. Cond. lever latency	2.4	3.4	8.1	-2.7	2.8	-1.1	-0.5	0.7
Pavlov. Cond. magazine entry latency	2.9	4.1	5.4	2.1	-2.1	-0.9	2.3	-2.3
Pavlov. Cond. change in total contacts	1.6	3.9	9.1	2.8	-3.0	1.2	0.6	-0.7
Pavlov. Cond. index score	2.7	4.3	9.2	2.9	-3.0	0.6	1.1	-1.5
Pavlov. Cond. latency score	1.9	3.1	7.0	2.5	-2.6	0.7	0.8	-1.1
Pavlov. Cond. lever contacts	2.5	3.7	8.6	2.8	-2.9	1.0	0.4	-0.9
Pavlov. Cond. magazine entry number	2.8	3.7	6.1	-2.4	2.5	0.2	-1.7	1.9
Pavlov. Cond. intertrial magazine entries	1.2	2.5	4.2	-1.6	1.6	0.7	-2.1	1.7
Pavlov. Cond. lever-magazine prob. diff.	2.8	4.3	9.5	3.0	-3.1	0.9	0.8	-1.2
Pavlov. Cond. response bias	3.6	5.0	10.1	3.0	-3.2	0.2	1.5	-1.9
Time in closed arm before self-admin	0.3	0.5	0.9	0.4	-0.5	-0.5	0.8	-1.0
Time in closed arm after self-admin	0.9	1.0	1.7	-0.4	0.4	-1.3	1.1	-1.3
Time in open arm before self-admin	0.4	0.5	1.1	-0.4	0.3	0.6	-1.0	1.1
Time in open arm after self-admin	1.0	1.1	1.9	0.6	-0.4	1.4	-1.1	1.3
Bone: periosteal estimation	1.0	2.4	4.4	2.1	-2.0	-0.0	1.5	-1.0
Bone: periosteal perimeter	0.5	0.9	1.7	0.7	-0.9	-0.7	1.3	-1.0
Bone: post-yield work	0.1	0.3	1.0	0.0	0.1	-0.4	0.2	-1.0
Progressive ratio test 1 active lever presses	0.2	0.4	0.9	0.5	-0.9	-0.3	0.6	-0.6
Progressive ratio test 1 breakpoint	0.3	0.5	1.2	0.7	-1.1	-0.2	0.6	-0.6
Progressive ratio test 1 inactive lever presses	1.0	2.5	4.6	0.1	-0.1	-1.9	2.1	-2.1
Progressive ratio test 2 active lever presses	0.3	0.4	0.8	0.3	-0.3	-0.7	0.8	-0.9
Progressive ratio test 2 breakpoint	0.4	0.5	0.9	0.3	-0.4	-0.8	0.8	-1.0
Progressive ratio test 2 inactive lever presses	1.0	3.2	5.8	1.0	-1.1	-1.6	2.4	-2.3
Incentive Sensitization - Responses	0.2	0.6	1.1	-0.2	0.3	-1.1	0.8	-1.0
Incentive Sensitization - Breakpoint	0.3	0.7	1.3	-0.1	0.1	-1.1	0.9	-1.1
Sum of active levers in priming session hrs 5-6	0.6	0.5	1.0	-0.5	0.5	-1.0	0.7	-0.8
Progressive ratio	0.9	2.5	4.9	-1.5	1.3	-2.2	1.4	-1.4
Food seeking constrained by brief footshock	2.1	2.6	4.7	-2.2	2.0	-0.3	-1.4	1.3
Seeking ratio, punishment vs. effort	1.0	2.1	3.6	0.6	-0.5	1.9	-1.8	1.8
Retroperitoneal fat weight	13.4	60.0	133.1	11.5	-11.3	5.6	1.9	-2.1
Reaction time number correct	0.2	0.8	1.4	-1.0	0.8	-1.2	0.4	-0.8
Reaction time mean minus median	0.3	1.7	3.4	1.8	-1.8	0.2	1.2	-0.6
Reaction time mean minus median AUC	0.3	1.8	3.3	1.7	-1.8	-0.0	1.4	-0.8
Reaction time num false alarms	0.8	1.3	2.5	-1.6	1.4	-1.3	0.6	-0.0
Reaction time num false alarms AUC	0.5	1.2	2.3	-1.5	1.5	-1.1	0.4	0.1
Reaction time trials correct on left	0.2	0.8	1.4	-1.0	0.8	-1.2	0.4	-0.8
Reaction time trials on left	0.2	0.8	1.4	-1.0	0.7	-1.2	0.5	-0.9
Reaction time mean	1.4	3.2	6.6	2.6	-2.6	0.5	1.4	-0.8
Reaction time mean AUC	1.1	2.7	5.7	2.4	-2.4	0.6	1.2	-0.6
Median of all reaction times	1.7	2.6	5.6	2.4	-2.4	0.5	1.1	-0.7
Reaction time omissions	0.5	0.9	1.5	1.2	-1.2	-0.0	0.9	-0.8
Reaction time false alarm rate	0.4	0.5	0.9	-0.9	1.0	-0.7	0.3	0.3
Reaction time premature initiation rate	0.3	0.5	1.3	-0.1	-0.1	-1.0	1.1	-0.6
Reaction time premature initiations	0.4	1.2	2.6	-0.6	0.3	-1.6	1.4	-1.0
Std. dev. reaction times	0.7	2.2	4.6	2.1	-2.1	0.4	1.2	-0.7
Reaction time trials completed	0.2	0.8	1.4	-1.0	0.7	-1.2	0.5	-0.9
Reaction time trials AUC	0.3	1.1	2.1	-0.9	0.6	-1.4	0.8	-1.3
Run reversals in cocaine runway, females	1.2	1.4	2.6	1.5	-1.6	1.3	-0.4	0.5
Run reversals in cocaine runway, males	1.5	1.7	3.0	1.3	-1.1	1.7	-1.1	1.1
Latency to leave start box in cocaine runway	0.3	0.4	0.6	-0.3	0.5	-0.7	0.6	-0.8
Latency to leave start box in cocaine runway, F	0.5	0.6	1.4	0.6	-0.4	-0.5	1.0	-1.2
Latency to leave start box in cocaine runway, M	0.9	0.8	1.8	-1.2	1.3	-0.9	0.2	-0.2
Std. dev. time between licks in bursts	0.3	0.6	1.2	-1.1	1.1	-0.2	-0.6	0.4
Total sessions with >9 infusions	0.3	0.3	0.6	0.2	-0.3	-0.7	0.8	-0.7
Short access day 1 total inactive lever presses	1.6	3.3	6.0	-0.1	0.6	-2.1	2.5	-2.3
Short access day 10 total inactive lever presses	0.5	3.6	7.4	0.7	-0.1	-1.8	2.7	-2.6
Short access day 1 total infusions	0.6	1.2	2.1	-1.2	1.3	-1.5	0.6	-0.6
Short access day 10 total infusions	0.3	0.6	1.0	0.3	-0.4	-0.8	1.0	-1.0
Short access total infusions	0.3	0.4	0.7	0.2	-0.3	-0.7	0.8	-0.8
Short access day 1 locomotion	0.0	0.0	0.1	-0.2	0.2	-0.3	0.1	-0.0
Short access day 10 total locomotion	0.1	0.4	0.8	-0.9	0.7	-0.9	0.1	-0.2
Short access total locomotion	0.3	0.4	0.6	-0.8	0.8	0.0	-0.7	0.7
One hour access (0.3 mA shock)	0.8	1.0	2.1	-0.8	0.7	-1.5	0.9	-0.9
Compulsive drug intake	1.3	1.9	4.6	-1.9	2.2	-0.6	-0.6	0.6
One hour access (shock baseline)	0.2	0.5	0.6	0.7	-0.8	-0.3	0.8	-0.7
Social response proportion	2.5	3.2	7.4	2.7	-2.4	1.6	0.4	-0.0
Social responses	0.4	0.5	1.3	1.0	-1.1	0.5	0.1	-0.0
Social time	1.0	1.6	2.6	1.6	-1.6	1.5	-0.6	0.3
Soleus weight	0.1	0.3	0.9	0.5	-0.3	-0.2	1.0	-0.5
Bone: stiffness	0.1	0.2	0.6	0.5	-0.4	0.1	0.1	-0.8
Tibialis anterior weight	0.4	1.3	3.5	1.9	-1.5	0.7	0.5	-0.2
Time to tail flick, vehicle, before self-admin	3.2	3.9	5.7	2.0	-2.0	-0.7	2.4	-2.4
Time to tail flick, vehicle, after self-admin	0.2	0.3	0.8	0.6	-0.1	-0.2	0.7	-0.9
Time to tail flick, test, before self-admin	0.3	0.3	0.5	-0.4	0.7	-0.7	0.4	-0.5
Time to tail flick, test, after self-admin	3.7	3.9	6.8	-0.2	0.0	-2.5	2.6	-2.6
Delta time to tail flick, vehicle, before/after SA	0.5	0.6	1.7	-1.0	1.3	-0.5	-0.2	0.1
Delta time to tail flick, test, before/after SA	0.6	0.8	1.6	0.2	-0.5	-0.9	1.3	-1.1
Tibia length	1.7	4.8	10.9	3.2	-3.3	1.2	0.9	-0.5
Ambulatory time before self-admin	0.2	0.6	1.0	0.9	-1.0	1.0	-0.6	0.4
Ambulatory time after self-admin	1.2	2.0	3.9	-0.9	0.8	1.1	-2.0	1.9
Bone: tissue strength	0.3	0.4	0.7	0.7	-0.9	0.5	-0.1	0.4
Total heroin consumption	1.3	1.5	2.9	0.1	0.2	-1.4	1.6	-1.7
Bone: trabecular number	0.3	0.6	1.4	-0.5	0.7	0.4	-0.8	1.2
Bone: trabecular spacing	0.8	1.2	2.5	1.6	-1.6	0.6	0.3	-0.7
Bone: trabecular thickness	0.3	0.4	0.9	-0.3	0.4	0.4	-0.8	1.0
Bone: trabecular tissue density	0.6	1.0	1.9	0.3	-0.2	1.4	-1.3	1.1
Water consumed over 24 hours	0.8	1.6	4.2	0.5	-0.7	-1.4	2.1	-0.9
Number of responses in last shaping day	1.3	1.7	3.4	-0.9	0.7	-1.8	1.4	-1.3