Hub : Genes

Adcy3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL mRNA stability Adcy3 0.03 0.03 6.3e-05 0.05 0.04 0.04 0.04 6.0e-06 2.8e-05 4.1e-05 3.2e-05
2 Liver mRNA stability Adcy3 0.17 0.1 6.2e-12 0.09 0.07 0.07 0.08 5.8e-10 2.0e-08 1.6e-08 2.0e-09
3 NAcc mRNA stability Adcy3 0.03 0.02 4.0e-05 0.03 0.02 0.02 0.03 2.9e-05 1.3e-04 2.3e-04 7.9e-05
4 Liver gene expression Adcy3 0.29 0.13 0.0e+00 0.12 0.06 0.12 0.06 1.2e-13 1.8e-07 1.2e-13 8.7e-07
5 Adipose gene expression Adcy3 0.44 0.13 5.6e-17 0.12 0.02 0.12 0.05 1.2e-13 4.1e-03 5.1e-13 2.7e-06
6 Brain gene expression Adcy3 0.2 0.15 2.9e-03 0.01 0.03 0.01 0.01 1.5e-02 1.5e-03 1.4e-02 2.7e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bone: apparent density2.74.75.6-2.32.3-2.42.01.82.2
Area under the delay curve0.00.00.1-0.20.1-0.3-0.0-0.10.0
BMI with tail2.910.112.83.3-3.63.2-3.4-3.5-1.8
BMI without tail2.88.610.23.2-3.23.1-3.0-2.9-2.1
Body weight2.711.914.83.8-3.93.6-3.5-3.6-1.9
Weight adjusted by age0.50.81.61.3-1.01.3-0.6-0.50.1
Bone surface0.40.71.0-1.01.0-0.90.90.60.6
Bone volume1.32.33.0-1.71.6-1.71.51.31.3
Breakpoint value in progressive ratio session0.60.71.0-0.81.0-0.81.01.00.2
Number of licking bursts1.32.13.41.3-1.51.4-1.7-1.8-0.7
Context. condit. distance diff. score0.20.20.4-0.50.6-0.40.40.20.4
Locomotion velocity, session 10.10.10.30.2-0.10.3-0.4-0.5-0.5
Locomotion distance, session 10.81.01.5-1.21.1-1.10.80.71.1
Locomotion velocity, session 20.60.71.20.7-0.90.7-0.8-1.1-0.5
Locomotion distance, session 20.00.00.1-0.30.0-0.2-0.1-0.20.0
Locomotion velocity, session 30.00.00.10.0-0.10.0-0.1-0.10.2
Locomotion distance, session 30.00.00.00.1-0.10.1-0.1-0.1-0.1
Stereotopy head waving bouts, day 32.42.84.2-1.51.8-1.61.92.01.0
Stereotopy head waving duration, day 30.30.40.7-0.50.7-0.50.80.80.3
Locomotion velocity, session 70.00.00.10.3-0.30.0-0.2-0.30.1
Locomotion distance, session 70.91.21.81.2-1.31.0-1.1-0.9-0.9
Stereotopy head waving bouts, day 70.10.10.2-0.30.4-0.1-0.2-0.20.4
Stereotopy head waving duration, day 70.40.51.1-0.70.8-0.50.40.31.1
Locomotion velocity, session 80.30.30.6-0.50.6-0.50.80.50.2
Locomotion distance, session 80.81.21.9-1.41.3-1.30.90.90.5
Degree of sensitization distance1.11.21.71.2-1.31.1-1.1-1.0-0.7
Degree of sensitization stereotypy0.40.41.10.3-0.30.6-0.9-1.00.2
Conditioned locomotion2.12.43.7-1.51.5-1.71.41.31.9
Cocaine response after cond. corrected0.10.10.4-0.30.3-0.30.20.10.6
Cocaine response after cond. not corrected0.60.70.9-0.80.8-0.80.70.70.9
Cocaine response before conditioning1.72.02.5-1.31.5-1.31.61.61.1
Saline control response1.31.72.0-1.31.4-1.41.31.31.1
Bone: connectivity density1.42.22.9-1.41.7-1.61.41.21.6
Bone: cortical apparent density0.10.20.4-0.10.4-0.20.60.7-0.4
Bone: cortical area0.00.00.10.1-0.10.0-0.2-0.30.2
Bone: cortical porosity2.12.33.0-1.41.4-1.51.61.41.7
Bone: cortical porosity1.81.92.6-1.31.2-1.41.51.21.6
Bone: cortical thickness0.10.20.30.5-0.40.4-0.5-0.4-0.5
Bone: cortical thickness0.40.50.6-0.70.5-0.80.80.80.5
Bone: cortical tissue density0.10.10.3-0.00.3-0.10.50.5-0.4
Condit. Reinf. active minus inactive responses2.73.03.71.9-1.91.8-1.7-1.7-1.3
Condit. Reinf. active-inactive response ratio2.72.84.32.1-1.81.9-1.4-1.2-1.7
Condit. Reinf. active responses0.20.30.40.6-0.60.5-0.6-0.6-0.2
Condit. Reinf. inactive responses1.51.82.9-1.71.3-1.51.11.01.4
Incentive salience index mean0.70.81.31.0-1.00.8-1.0-1.1-0.1
Condit. Reinf. lever presses0.71.02.8-0.90.8-1.00.60.21.7
Condit. Reinf. active minus inactive responses0.71.01.3-0.90.8-0.91.01.11.1
Condit. Reinf. active-inactive response ratio0.30.41.3-0.40.5-0.50.40.31.1
Condit. Reinf. active responses0.50.71.2-0.90.8-0.80.70.91.1
Condit. Reinf. inactive responses0.20.20.5-0.60.4-0.50.30.30.7
Condit. Reinf. lever presses0.91.21.5-1.21.0-1.01.21.21.0
Condit. Reinf. lever reinforcers received0.40.61.0-0.70.6-0.60.70.81.0
Conditioned reinforcement - actives2.95.06.3-2.22.5-2.32.42.21.7
Conditioned reinforcement - inactives5.78.310.2-3.03.2-3.22.82.42.6
Conditioned locomotion2.43.15.4-1.61.6-1.62.32.20.6
Patch foraging indifference point 0 sec0.10.30.90.5-0.20.3-0.4-0.3-0.9
Patch foraging indifference point AUC0.00.10.2-0.30.0-0.2-0.2-0.10.4
Delay disc. indifference point, 0s delay0.20.20.50.20.00.2-0.5-0.5-0.7
Delay disc. indifference point, 16s delay0.00.00.0-0.1-0.1-0.00.10.1-0.0
Delay disc. indifference point, 2s delay0.20.21.20.1-0.1-0.10.10.1-1.1
Delay disc. indifference point, 24s delay2.73.03.5-1.91.5-1.91.71.61.7
Delay disc. indifference point, 4s delay0.10.10.50.2-0.10.0-0.2-0.3-0.7
Delay disc. indifference point, 8s delay0.00.00.1-0.20.2-0.30.10.10.0
Indifference point function ln k1.42.43.2-1.61.8-1.71.61.41.4
Indifference point function log k1.42.43.2-1.61.8-1.71.61.41.4
Patch foraging total patch changes 0 sec0.10.20.80.5-0.20.3-0.4-0.3-0.9
Patch foraging total patch changes 12 sec1.41.92.41.5-1.51.4-1.6-1.5-0.5
Patch foraging total patch changes 18 sec0.50.71.00.8-0.81.0-0.7-0.6-1.0
Patch foraging total patch changes 24 sec0.71.21.80.8-1.01.1-1.3-1.3-0.9
Patch foraging total patch changes 6 sec1.11.72.21.3-1.31.2-1.5-1.3-1.2
Patch foraging time to switch 0 sec0.61.31.81.3-1.31.3-0.8-0.6-1.2
Patch foraging water rate 0 sec2.14.36.1-2.32.5-2.32.02.01.2
Patch foraging water rate 12 sec0.00.00.0-0.00.1-0.1-0.10.0-0.1
Patch foraging water rate 18 sec2.53.95.4-2.22.3-2.21.91.91.0
Patch foraging water rate 24 sec0.10.20.30.6-0.50.5-0.2-0.3-0.6
Patch foraging water rate 6 sec1.01.52.4-1.21.5-1.31.21.30.3
Seeking ratio, delayed vs. immediate footshock0.40.50.70.8-0.80.8-0.5-0.6-0.5
Distance traveled before self-admin0.10.10.2-0.4-0.1-0.30.20.20.4
Distance traveled after self-admin0.30.41.60.4-0.10.5-0.3-0.1-1.2
Extensor digitorum longus weight2.18.49.1-3.02.8-3.02.92.73.0
Bone: elastic displacement1.92.22.8-1.51.6-1.41.61.71.1
Bone: elastic work1.11.42.0-1.11.3-1.21.41.40.3
Bone: endosteal estimation0.20.51.0-1.00.5-0.90.60.50.6
Bone: endosteal perimeter0.00.10.3-0.1-0.10.1-0.2-0.40.5
Epididymis fat weight19.867.778.78.9-8.78.8-8.2-8.2-6.2
Delta time in closed arm before/after self-admin0.00.00.10.20.00.1-0.00.0-0.2
Delta time in open arm before/after self-admin0.40.40.80.2-0.70.1-0.7-0.90.8
Diff in mean of infusions in LGA sessions0.50.60.90.8-0.80.9-0.8-1.00.0
Delay discount exponential model param0.10.10.30.5-0.30.6-0.3-0.2-0.1
Extinction: sum of active levers before priming0.10.10.5-0.10.3-0.10.1-0.10.7
Active lever presses in extinction session 61.61.66.7-0.90.8-1.00.40.12.6
Bone: final force0.10.20.40.5-0.40.3-0.4-0.60.2
Bone: final moment0.00.10.20.3-0.20.2-0.3-0.40.2
Food consumed during 24 hour testing period0.10.10.2-0.50.2-0.4-0.00.10.1
Glucose0.91.42.11.2-1.31.4-1.1-0.9-1.0
Heart weight0.91.41.91.1-1.01.3-1.2-1.1-1.4
Delay discount hyperbolic model param0.00.00.10.2-0.10.3-0.1-0.00.2
Intermittent access intake day 1-15 change1.63.24.3-1.92.0-1.92.02.1-0.0
Intermittent access intake escalation1.22.53.4-1.61.8-1.71.71.8-0.4
Intermittent access intake escalation 21.61.82.9-1.21.3-1.41.51.7-0.9
Intermitt. access day 1 inactive lever presses0.31.33.7-1.10.9-1.30.50.11.9
Intermitt. access day 15 inactive lever presses0.61.12.8-0.81.0-1.00.80.71.7
Intermitt. access escalation Index3.54.99.72.2-1.92.5-1.7-1.3-3.1
Intermittent access day 1 total infusions1.11.84.7-1.31.4-1.20.80.52.2
Intermittent access day 15 total infusions2.33.44.9-2.12.2-2.01.71.61.3
Intermittent access terminal intake (last 3 days)3.64.76.5-2.52.5-2.42.01.91.5
Intermittent access total infusions3.03.64.7-2.02.0-1.91.71.52.2
Intermittent access day 1 locomotion2.22.83.7-1.91.7-1.81.31.01.9
Intermittent access day 15 total locomotion0.20.40.7-0.80.9-0.70.60.60.2
Intermittent access total locomotion1.61.92.7-1.71.4-1.51.31.11.3
Intermittent access standard deviation1.43.04.1-2.01.7-2.01.61.61.4
Left kidney weight0.10.52.70.2-0.2-0.1-0.0-0.41.7
Right kidney weight0.52.13.11.8-1.61.4-1.3-1.60.4
Cocaine induced anxiety0.10.20.6-0.20.8-0.10.50.5-0.1
Post-drug Anxiety1.31.32.01.0-0.91.2-1.4-1.4-0.8
Baseline Anxiety3.13.64.71.7-2.11.9-2.2-2.1-1.3
Tail length0.10.51.0-0.41.0-0.40.71.00.2
Length with tail0.10.30.80.9-0.50.7-0.3-0.30.1
Length without tail0.10.51.20.6-0.70.4-0.4-0.81.1
Times rat made contact with spout0.91.01.4-1.11.0-1.21.00.80.8
Lifetime Intake3.23.94.9-2.12.1-2.01.81.62.2
Liver weight, left1.62.63.31.8-1.41.8-1.6-1.6-1.4
Liver weight, right3.35.76.62.5-2.52.6-2.5-2.5-1.6
Locomotor activity2.03.15.11.7-1.91.6-2.0-2.20.4
Locomotor testing distance1.22.23.61.5-1.41.4-1.7-1.90.4
Locomotor testing rearing0.20.41.70.3-0.30.1-0.3-0.61.3
Locomotion in novel chamber1.21.52.91.0-1.31.0-1.3-1.70.8
Locomotion in novel chamber post-restriction1.01.74.01.3-1.11.3-1.1-0.8-2.0
Fecal boli incidents, locomotor time 12.63.75.4-2.11.9-2.31.91.81.4
Change in fecal boli incidents, locomotor task4.54.46.92.6-1.92.5-1.4-1.1-2.6
Time >=10cm from walls, locomotor time 10.30.30.5-0.30.4-0.50.70.70.7
Bouts of movement, locomotor time 10.30.41.0-0.71.0-0.9-0.0-0.10.1
Total resting periods, locomotor time 10.40.41.1-0.81.1-0.90.10.20.0
Rest time, locomotor task time 10.10.20.9-0.00.2-0.0-0.10.2-1.0
Distance moved, locomotor task time 10.40.50.90.8-0.90.8-0.5-0.80.5
Vertical activity count, locomotor time 10.00.10.10.2-0.30.4-0.1-0.2-0.1
Time >=10cm from walls, locomotor time 20.91.42.9-0.91.1-0.91.71.60.6
Bouts of movement, locomotor time 20.10.10.6-0.10.1-0.4-0.2-0.0-0.8
Total resting periods, locomotor time 20.10.10.5-0.10.1-0.3-0.3-0.2-0.7
Rest time, locomotor task time 20.10.10.1-0.20.3-0.3-0.3-0.40.2
Distance moved, locomotor task time 20.00.10.10.1-0.20.30.30.2-0.2
Vertical activity count, locomotor time 20.10.20.40.00.30.30.60.4-0.6
Light reinforcement 10.51.11.6-1.01.3-1.10.80.91.2
Light reinforcement 21.82.84.6-1.61.8-1.61.92.10.3
Bone: marrow area0.20.50.9-1.00.5-0.80.60.40.6
Bone: maximum diameter0.10.10.2-0.40.3-0.40.10.10.4
Bone: maximum force0.00.00.10.0-0.1-0.2-0.1-0.20.4
Bone: maximum moment0.00.00.1-0.10.2-0.30.10.00.3
Mean time between licks in bursts0.51.31.61.0-1.21.0-1.3-1.2-1.2
Mean num. licks in bursts2.23.44.7-1.82.0-1.92.12.20.8
Cd content in liver0.30.40.70.8-0.70.7-0.5-0.5-0.3
Co content in liver2.93.36.0-1.81.5-1.81.71.52.4
Cu content in liver0.20.20.70.2-0.40.2-0.4-0.50.9
Fe content in liver1.92.32.8-1.61.4-1.71.51.31.5
K content in liver0.90.81.20.8-1.00.9-1.1-1.0-0.0
Mg content in liver0.00.00.10.1-0.20.2-0.2-0.1-0.0
Mn content in liver0.70.81.50.8-1.00.8-0.7-0.6-1.2
Na content in liver3.03.24.0-1.92.0-1.81.61.71.7
Rb content in liver0.30.30.50.7-0.50.7-0.6-0.6-0.3
Se content in liver0.30.40.60.7-0.80.7-0.5-0.5-0.3
Sr content in liver0.30.20.3-0.40.3-0.40.60.6-0.5
Zn content in liver1.51.72.31.3-1.31.4-1.5-1.5-0.2
Bone: minimum diameter1.01.82.81.3-1.41.3-1.5-1.7-0.5
Time in familiar zone, hab. session 11.61.62.11.3-1.41.3-1.2-1.3-0.9
Time in novel zone, hab. session 10.40.40.70.8-0.60.7-0.4-0.5-0.7
Total zone transitions, hab. session 10.70.91.5-1.20.9-1.20.60.61.1
Total locomotion distance, hab. session 11.31.82.3-1.51.4-1.51.11.01.4
Locomotion velocity, hab. session 12.43.44.4-2.02.0-2.11.61.61.8
Time in familiar zone, hab. session 20.40.41.50.5-0.50.5-0.2-0.1-1.2
Time in novel zone, hab. session 20.30.30.50.7-0.70.6-0.5-0.70.1
Total zone transitions, hab. session 20.10.10.4-0.60.4-0.50.10.00.0
Total locomotion distance, hab. session 20.10.10.3-0.50.3-0.3-0.1-0.10.0
Locomotion velocity, hab. session 20.10.20.4-0.70.5-0.5-0.0-0.00.4
Novel to familiar place preference ratio0.00.00.10.00.1-0.0-0.3-0.2-0.1
Novelty place preference0.10.20.40.3-0.20.3-0.6-0.5-0.2
Time in novel zone, NPP test0.30.30.50.5-0.40.5-0.7-0.7-0.3
Total zone transitions, NPP test0.91.32.6-1.31.0-1.20.80.61.6
Total locomotion distance, NPP test1.62.23.0-1.71.4-1.61.21.11.7
Locomotion velocity, NPP test2.63.64.7-2.21.9-2.11.51.52.2
Intraocular pressure3.85.46.92.6-2.42.5-2.0-1.8-2.6
Delta distance traveled before/after self-admin1.31.31.81.1-0.71.1-1.3-1.3-1.3
Delta ambulatory time before/after self-admin0.20.21.30.10.30.1-0.2-0.1-1.2
Parametrial fat weight24.357.267.58.1-8.27.8-8.1-7.8-4.8
Pavlov. Cond. lever latency0.50.61.70.7-0.70.8-0.4-0.1-1.3
Pavlov. Cond. magazine entry latency0.10.10.2-0.10.1-0.0-0.3-0.40.4
Pavlov. Cond. change in total contacts0.00.10.1-0.20.3-0.30.0-0.20.3
Pavlov. Cond. index score0.10.10.4-0.30.3-0.3-0.1-0.40.7
Pavlov. Cond. latency score0.10.10.3-0.30.2-0.3-0.1-0.30.5
Pavlov. Cond. lever contacts0.50.61.7-0.70.6-0.80.3-0.01.3
Pavlov. Cond. magazine entry number0.20.30.70.5-0.50.60.00.2-0.8
Pavlov. Cond. intertrial magazine entries0.70.81.4-0.70.7-0.71.21.20.9
Pavlov. Cond. lever-magazine prob. diff.0.30.41.1-0.60.6-0.60.2-0.01.0
Pavlov. Cond. response bias0.80.92.3-0.90.9-1.10.50.31.5
Pavlov. Cond. lever latency0.50.71.01.0-0.80.8-0.8-0.9-0.5
Pavlov. Cond. magazine entry latency0.00.00.10.0-0.20.2-0.10.0-0.2
Pavlov. Cond. change in total contacts0.00.00.1-0.3-0.1-0.10.20.20.1
Pavlov. Cond. index score0.30.40.6-0.70.5-0.50.70.80.3
Pavlov. Cond. latency score0.30.40.7-0.80.5-0.50.80.90.2
Pavlov. Cond. lever contacts0.20.30.5-0.70.5-0.50.50.50.4
Pavlov. Cond. magazine entry number0.20.20.5-0.40.7-0.60.40.30.3
Pavlov. Cond. intertrial magazine entries1.32.04.11.4-1.11.4-1.1-1.2-2.0
Pavlov. Cond. lever-magazine prob. diff.0.10.10.3-0.40.2-0.20.50.5-0.0
Pavlov. Cond. response bias0.40.50.9-1.00.6-0.70.70.70.7
Time in closed arm before self-admin0.20.20.60.4-0.50.4-0.6-0.70.1
Time in closed arm after self-admin1.21.32.01.2-1.01.2-1.2-1.4-0.1
Time in open arm before self-admin0.10.10.2-0.1-0.1-0.10.20.4-0.5
Time in open arm after self-admin0.10.20.3-0.50.3-0.60.40.40.2
Bone: periosteal estimation0.20.40.7-0.90.4-0.80.40.30.8
Bone: periosteal perimeter0.00.10.3-0.10.1-0.1-0.1-0.20.6
Bone: post-yield work1.21.72.1-1.41.2-1.41.51.31.2
Progressive ratio test 1 active lever presses1.92.35.0-1.51.3-1.71.10.92.2
Progressive ratio test 1 breakpoint1.92.45.0-1.51.4-1.71.11.02.2
Progressive ratio test 1 inactive lever presses2.53.59.0-1.81.7-1.91.30.93.0
Progressive ratio test 2 active lever presses3.44.04.6-2.12.1-2.12.11.91.5
Progressive ratio test 2 breakpoint3.43.84.6-2.12.1-2.12.01.91.4
Progressive ratio test 2 inactive lever presses3.45.57.0-2.42.6-2.52.52.31.6
Incentive Sensitization - Responses2.23.24.7-1.81.9-1.62.22.00.8
Incentive Sensitization - Breakpoint2.12.74.3-1.61.8-1.52.12.00.5
Sum of active levers in priming session hrs 5-60.10.10.2-0.00.1-0.1-0.5-0.4-0.2
Progressive ratio0.10.20.60.2-0.50.4-0.5-0.80.0
Food seeking constrained by brief footshock8.910.917.1-3.43.0-3.23.22.74.1
Seeking ratio, punishment vs. effort1.72.53.3-1.51.6-1.61.71.81.2
Retroperitoneal fat weight41.3176.4205.414.3-14.014.3-13.3-12.9-10.5
Reaction time number correct0.30.60.9-0.91.0-0.70.70.50.7
Reaction time mean minus median0.71.72.71.5-1.51.6-1.1-1.3-0.1
Reaction time mean minus median AUC0.61.41.91.2-1.31.4-1.3-1.40.1
Reaction time num false alarms2.13.04.11.7-1.71.8-2.0-2.0-0.6
Reaction time num false alarms AUC1.82.74.01.6-1.61.7-2.0-2.0-0.5
Reaction time trials correct on left0.30.60.9-0.91.0-0.70.70.50.7
Reaction time trials on left0.30.50.7-0.80.9-0.60.60.40.8
Reaction time mean0.30.50.80.7-0.70.9-0.7-0.6-0.5
Reaction time mean AUC0.20.20.40.5-0.50.6-0.5-0.5-0.2
Median of all reaction times0.00.10.20.2-0.10.3-0.2-0.0-0.5
Reaction time omissions1.62.45.01.1-1.61.1-1.9-2.20.9
Reaction time false alarm rate2.63.54.42.0-2.02.0-2.1-2.0-1.1
Reaction time premature initiation rate0.00.10.3-0.1-0.0-0.20.10.2-0.6
Reaction time premature initiations0.20.30.4-0.60.6-0.60.60.6-0.1
Std. dev. reaction times1.01.82.71.4-1.51.6-1.4-1.4-0.3
Reaction time trials completed0.30.50.7-0.80.9-0.60.60.40.8
Reaction time trials AUC0.20.40.7-0.70.8-0.60.50.40.9
Run reversals in cocaine runway, females0.90.91.3-0.91.1-0.81.01.10.5
Run reversals in cocaine runway, males1.01.01.6-1.01.3-1.00.80.61.2
Latency to leave start box in cocaine runway0.20.20.7-0.30.1-0.40.80.80.1
Latency to leave start box in cocaine runway, F0.20.20.40.6-0.70.5-0.2-0.1-0.4
Latency to leave start box in cocaine runway, M1.11.11.8-0.91.0-1.01.21.30.5
Std. dev. time between licks in bursts0.30.40.60.5-0.70.3-0.8-0.7-0.8
Total sessions with >9 infusions2.32.73.8-1.91.7-1.71.61.51.5
Short access day 1 total inactive lever presses4.55.98.6-2.82.9-2.62.01.72.4
Short access day 10 total inactive lever presses0.30.62.3-0.60.7-0.70.1-0.31.5
Short access day 1 total infusions2.22.93.6-1.71.9-1.61.71.51.9
Short access day 10 total infusions2.32.93.9-1.72.0-1.51.61.42.0
Short access total infusions1.51.93.0-1.41.4-1.31.21.01.7
Short access day 1 locomotion1.41.74.4-1.31.2-1.21.00.62.1
Short access day 10 total locomotion1.22.22.8-1.71.4-1.61.51.31.4
Short access total locomotion2.02.43.1-1.81.4-1.71.51.51.3
One hour access (0.3 mA shock)4.95.78.0-2.22.8-2.42.82.80.6
Compulsive drug intake1.21.57.20.8-0.20.7-0.5-0.2-2.7
One hour access (shock baseline)4.06.16.8-2.52.6-2.62.62.32.3
Social response proportion0.30.30.90.7-0.50.50.30.3-0.9
Social responses0.40.51.01.0-0.80.7-0.6-0.5-0.7
Social time0.00.10.10.3-0.30.30.10.2-0.2
Soleus weight3.710.913.5-3.73.6-3.63.23.02.6
Bone: stiffness0.00.10.20.1-0.10.0-0.4-0.50.1
Tibialis anterior weight1.34.45.3-2.32.2-2.32.02.01.8
Time to tail flick, vehicle, before self-admin0.60.61.80.2-0.30.2-0.8-1.11.3
Time to tail flick, vehicle, after self-admin5.77.59.33.0-3.12.9-2.9-2.8-1.6
Time to tail flick, test, before self-admin0.20.20.4-0.40.2-0.50.40.10.7
Time to tail flick, test, after self-admin1.11.21.4-1.11.0-1.21.10.91.1
Delta time to tail flick, vehicle, before/after SA1.91.92.61.5-1.41.4-1.2-1.0-1.6
Delta time to tail flick, test, before/after SA2.42.54.3-1.41.6-1.41.92.10.6
Tibia length0.61.62.11.4-1.11.3-1.2-1.2-1.4
Ambulatory time before self-admin0.10.10.5-0.4-0.1-0.20.10.10.7
Ambulatory time after self-admin0.10.10.50.00.20.2-0.2-0.1-0.7
Bone: tissue strength0.40.40.70.7-0.30.6-0.6-0.5-0.9
Total heroin consumption4.65.47.2-2.62.4-2.52.52.70.7
Bone: trabecular number2.54.14.7-2.12.2-2.11.91.72.1
Bone: trabecular spacing0.30.40.70.5-0.70.5-0.8-0.6-0.6
Bone: trabecular thickness0.10.10.30.0-0.1-0.00.30.10.6
Bone: trabecular tissue density0.10.10.2-0.30.3-0.10.20.20.5
Water consumed over 24 hours0.10.10.20.0-0.3-0.0-0.5-0.4-0.1
Number of responses in last shaping day1.11.21.6-1.01.1-1.01.21.31.0