Hub : Genes

Adcy3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL mRNA stability Adcy3 0.03 0.03 6.3e-05 0.05 0.04 0.04 0.04 6.0e-06 2.8e-05 4.1e-05 3.3e-05
2 Liver mRNA stability Adcy3 0.17 0.1 6.2e-12 0.09 0.07 0.07 0.08 5.8e-10 2.0e-08 1.6e-08 2.1e-09
3 NAcc mRNA stability Adcy3 0.03 0.02 4.0e-05 0.03 0.02 0.02 0.03 2.9e-05 1.3e-04 2.1e-04 7.5e-05
4 Liver gene expression Adcy3 0.29 0.13 0.0e+00 0.12 0.06 0.12 0.06 1.2e-13 1.8e-07 1.2e-13 8.5e-07
5 Adipose gene expression Adcy3 0.44 0.13 5.6e-17 0.12 0.02 0.12 0.05 1.2e-13 4.1e-03 5.1e-13 3.0e-06
6 Brain gene expression Adcy3 0.2 0.15 2.9e-03 0.01 0.03 0.01 0.01 1.5e-02 1.5e-03 1.3e-02 2.9e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bone: apparent density2.54.75.62.3-2.32.4-2.0-1.82.2
Area under the delay curve0.00.00.10.2-0.10.30.00.10.0
BMI with tail2.910.112.8-3.33.6-3.23.43.5-1.8
BMI without tail1.68.610.2-3.23.2-3.13.02.9-2.1
Body weight2.711.914.8-3.83.9-3.63.53.6-1.9
Weight adjusted by age0.30.81.6-1.31.0-1.30.60.50.1
Bone surface0.40.71.01.0-1.00.9-0.9-0.60.6
Bone volume1.22.33.01.7-1.61.7-1.5-1.31.3
Breakpoint value in progressive ratio session0.40.71.00.8-1.00.8-1.0-1.00.2
Number of licking bursts0.72.13.4-1.31.5-1.41.71.8-0.7
Context. condit. distance diff. score0.20.20.40.5-0.60.4-0.4-0.20.4
Locomotion velocity, session 10.10.10.3-0.20.1-0.30.40.5-0.5
Locomotion distance, session 10.81.01.51.2-1.11.1-0.8-0.71.1
Locomotion velocity, session 20.50.71.2-0.70.9-0.70.81.1-0.5
Locomotion distance, session 20.00.00.10.3-0.00.20.10.20.0
Locomotion velocity, session 30.00.00.1-0.00.1-0.00.10.10.2
Locomotion distance, session 30.00.00.0-0.10.1-0.10.10.1-0.1
Stereotopy head waving bouts, day 32.42.84.21.5-1.81.6-1.9-2.01.0
Stereotopy head waving duration, day 30.30.40.70.5-0.70.5-0.8-0.80.3
Locomotion velocity, session 70.00.00.1-0.30.3-0.00.20.30.1
Locomotion distance, session 70.91.21.8-1.21.3-1.01.10.9-0.9
Stereotopy head waving bouts, day 70.10.10.20.3-0.40.10.10.20.4
Stereotopy head waving duration, day 70.40.51.10.7-0.80.5-0.4-0.31.1
Locomotion velocity, session 80.30.30.60.5-0.60.5-0.8-0.50.2
Locomotion distance, session 80.81.21.91.4-1.31.3-0.9-0.90.5
Degree of sensitization distance1.11.21.7-1.21.3-1.11.11.0-0.7
Degree of sensitization stereotypy0.40.41.1-0.30.3-0.60.91.00.2
Conditioned locomotion2.12.43.71.5-1.51.7-1.4-1.31.9
Cocaine response after cond. corrected0.10.10.40.3-0.30.3-0.2-0.10.6
Cocaine response after cond. not corrected0.50.70.90.8-0.80.8-0.7-0.70.9
Cocaine response before conditioning1.72.02.51.3-1.51.3-1.6-1.61.1
Saline control response1.21.72.01.3-1.41.4-1.3-1.31.1
Bone: connectivity density1.42.22.91.4-1.71.6-1.4-1.21.6
Bone: cortical apparent density0.10.20.40.1-0.40.2-0.6-0.7-0.4
Bone: cortical area0.00.00.1-0.10.1-0.00.20.30.2
Bone: cortical porosity2.12.33.01.4-1.41.5-1.7-1.41.7
Bone: cortical porosity1.81.92.61.3-1.21.4-1.5-1.21.6
Bone: cortical thickness0.10.20.3-0.50.4-0.40.50.4-0.5
Bone: cortical thickness0.40.50.60.7-0.50.8-0.8-0.80.5
Bone: cortical tissue density0.10.10.30.0-0.30.1-0.5-0.5-0.4
Condit. Reinf. active minus inactive responses2.73.03.7-1.91.9-1.81.71.7-1.3
Condit. Reinf. active-inactive response ratio2.72.84.3-2.11.8-1.91.41.2-1.7
Condit. Reinf. active responses0.20.30.4-0.60.6-0.50.60.6-0.2
Condit. Reinf. inactive responses1.41.82.91.7-1.31.5-1.1-1.01.4
Incentive salience index mean0.70.81.3-1.01.0-0.81.01.1-0.1
Condit. Reinf. lever presses0.61.02.80.9-0.81.0-0.6-0.21.7
Condit. Reinf. active minus inactive responses0.61.01.30.9-0.80.9-1.0-1.11.1
Condit. Reinf. active-inactive response ratio0.20.41.30.4-0.50.5-0.4-0.31.1
Condit. Reinf. active responses0.50.71.20.9-0.80.8-0.7-0.91.1
Condit. Reinf. inactive responses0.20.20.50.6-0.40.5-0.3-0.30.7
Condit. Reinf. lever presses0.81.21.51.2-1.01.0-1.2-1.21.0
Condit. Reinf. lever reinforcers received0.40.61.00.7-0.60.6-0.7-0.81.0
Conditioned reinforcement - actives1.35.06.32.2-2.52.3-2.4-2.21.7
Conditioned reinforcement - inactives3.08.310.23.0-3.23.2-2.8-2.42.6
Conditioned locomotion2.13.15.41.6-1.61.6-2.3-2.20.6
Patch foraging indifference point 0 sec0.10.30.9-0.50.2-0.30.40.3-0.9
Patch foraging indifference point AUC0.00.10.20.3-0.00.20.20.10.4
Delay disc. indifference point, 0s delay0.20.20.5-0.2-0.0-0.20.50.5-0.7
Delay disc. indifference point, 16s delay0.00.00.00.10.10.0-0.1-0.1-0.0
Delay disc. indifference point, 2s delay0.20.21.2-0.10.10.1-0.1-0.1-1.1
Delay disc. indifference point, 24s delay1.93.03.51.9-1.51.9-1.7-1.61.7
Delay disc. indifference point, 4s delay0.10.10.5-0.20.1-0.00.20.3-0.7
Delay disc. indifference point, 8s delay0.00.00.10.2-0.20.3-0.1-0.10.0
Indifference point function ln k0.82.43.21.6-1.81.7-1.6-1.41.4
Indifference point function log k0.82.43.21.6-1.81.7-1.6-1.41.4
Patch foraging total patch changes 0 sec0.10.20.8-0.50.2-0.30.40.3-0.9
Patch foraging total patch changes 12 sec1.41.92.4-1.51.5-1.41.61.5-0.5
Patch foraging total patch changes 18 sec0.30.71.0-0.80.8-1.00.70.6-1.0
Patch foraging total patch changes 24 sec0.31.21.8-0.81.0-1.11.31.3-0.9
Patch foraging total patch changes 6 sec1.01.72.2-1.31.3-1.21.51.3-1.2
Patch foraging time to switch 0 sec0.31.31.8-1.31.3-1.30.80.6-1.2
Patch foraging water rate 0 sec1.14.36.12.3-2.52.3-2.0-2.01.2
Patch foraging water rate 12 sec0.00.00.00.0-0.10.10.1-0.0-0.1
Patch foraging water rate 18 sec1.73.95.42.2-2.32.2-1.9-1.91.0
Patch foraging water rate 24 sec0.10.20.3-0.60.5-0.50.20.3-0.6
Patch foraging water rate 6 sec1.01.52.41.2-1.51.3-1.2-1.30.3
Seeking ratio, delayed vs. immediate footshock0.30.50.7-0.80.8-0.80.50.6-0.5
Distance traveled before self-admin0.00.10.20.40.10.3-0.2-0.20.4
Distance traveled after self-admin0.20.41.6-0.40.1-0.50.30.1-1.2
Extensor digitorum longus weight2.18.49.13.0-2.83.0-2.9-2.73.0
Bone: elastic displacement1.82.22.81.5-1.61.4-1.6-1.71.1
Bone: elastic work1.11.42.01.1-1.31.2-1.4-1.40.3
Bone: endosteal estimation0.20.51.01.0-0.50.9-0.6-0.50.6
Bone: endosteal perimeter0.00.10.30.10.1-0.10.20.40.5
Epididymis fat weight13.467.878.7-8.98.7-8.88.28.2-6.2
Delta time in closed arm before/after self-admin0.00.00.1-0.2-0.0-0.10.0-0.0-0.2
Delta time in open arm before/after self-admin0.30.40.8-0.20.7-0.10.70.90.8
Diff in mean of infusions in LGA sessions0.30.60.9-0.80.8-0.90.81.00.0
Delay discount exponential model param0.10.10.3-0.50.3-0.60.30.2-0.1
Extinction: sum of active levers before priming0.10.10.50.1-0.30.1-0.10.10.7
Active lever presses in extinction session 61.51.66.70.9-0.81.0-0.4-0.12.6
Bone: final force0.10.20.4-0.50.4-0.30.40.60.2
Bone: final moment0.00.10.2-0.30.2-0.20.30.40.2
Food consumed during 24 hour testing period0.00.10.20.5-0.20.40.0-0.10.1
Glucose0.91.42.1-1.21.3-1.41.10.9-1.0
Heart weight0.81.41.9-1.11.0-1.31.21.1-1.4
Delay discount hyperbolic model param0.00.00.1-0.20.1-0.30.10.00.2
Intermittent access intake day 1-15 change0.63.24.31.9-2.01.9-2.0-2.1-0.0
Intermittent access intake escalation0.52.53.41.6-1.81.7-1.7-1.8-0.4
Intermittent access intake escalation 21.11.82.91.2-1.31.4-1.5-1.7-0.9
Intermitt. access day 1 inactive lever presses0.11.33.71.1-0.91.3-0.5-0.11.9
Intermitt. access day 15 inactive lever presses0.21.12.80.8-1.01.0-0.8-0.71.7
Intermitt. access escalation Index1.64.99.7-2.21.9-2.51.71.3-3.1
Intermittent access day 1 total infusions0.61.84.71.3-1.41.2-0.8-0.52.2
Intermittent access day 15 total infusions1.43.44.92.1-2.22.0-1.7-1.61.3
Intermittent access terminal intake (last 3 days)2.74.76.52.5-2.52.4-2.0-1.91.5
Intermittent access total infusions3.03.64.72.0-2.01.9-1.7-1.52.2
Intermittent access day 1 locomotion1.52.83.71.9-1.71.8-1.3-1.01.9
Intermittent access day 15 total locomotion0.10.40.70.8-0.90.7-0.6-0.60.2
Intermittent access total locomotion1.61.92.71.7-1.41.5-1.3-1.11.3
Intermittent access standard deviation0.63.04.12.0-1.72.0-1.6-1.61.4
Left kidney weight0.10.52.7-0.20.20.10.00.41.7
Right kidney weight0.32.13.1-1.81.6-1.41.31.60.4
Cocaine induced anxiety0.10.20.60.2-0.80.1-0.5-0.5-0.1
Post-drug Anxiety1.21.32.0-1.00.9-1.21.41.4-0.8
Baseline Anxiety2.13.64.7-1.72.1-1.92.22.1-1.3
Tail length0.10.51.00.4-1.00.4-0.7-1.00.2
Length with tail0.10.30.8-0.90.5-0.70.30.30.1
Length without tail0.10.51.2-0.60.7-0.40.40.81.1
Times rat made contact with spout0.91.01.41.1-1.01.2-1.0-0.80.8
Lifetime Intake3.13.94.92.1-2.12.0-1.8-1.62.2
Liver weight, left1.52.63.3-1.81.4-1.81.61.6-1.4
Liver weight, right3.35.76.6-2.52.5-2.62.52.5-1.6
Locomotor activity2.03.15.1-1.71.9-1.62.02.20.4
Locomotor testing distance0.92.23.6-1.51.4-1.41.71.90.4
Locomotor testing rearing0.10.41.7-0.30.3-0.10.30.61.3
Locomotion in novel chamber1.11.52.9-1.01.3-1.01.31.70.8
Locomotion in novel chamber post-restriction0.61.74.0-1.31.1-1.31.10.8-2.0
Fecal boli incidents, locomotor time 11.43.75.42.1-1.92.3-1.9-1.81.4
Change in fecal boli incidents, locomotor task4.24.46.9-2.61.9-2.51.41.1-2.6
Time >=10cm from walls, locomotor time 10.30.30.50.3-0.40.5-0.7-0.70.7
Bouts of movement, locomotor time 10.30.41.00.7-1.00.90.00.10.1
Total resting periods, locomotor time 10.40.41.10.8-1.10.9-0.1-0.20.0
Rest time, locomotor task time 10.10.20.90.0-0.20.00.1-0.2-1.0
Distance moved, locomotor task time 10.20.50.9-0.80.9-0.80.50.80.5
Vertical activity count, locomotor time 10.00.10.1-0.20.3-0.40.10.2-0.1
Time >=10cm from walls, locomotor time 20.51.42.90.9-1.10.9-1.7-1.60.6
Bouts of movement, locomotor time 20.00.10.60.1-0.10.40.20.0-0.8
Total resting periods, locomotor time 20.00.10.50.1-0.10.30.30.2-0.7
Rest time, locomotor task time 20.00.10.10.2-0.30.30.30.40.2
Distance moved, locomotor task time 20.00.10.1-0.10.2-0.3-0.3-0.2-0.2
Vertical activity count, locomotor time 20.10.20.4-0.0-0.3-0.3-0.6-0.4-0.6
Light reinforcement 10.31.11.61.0-1.31.1-0.8-0.91.2
Light reinforcement 21.22.84.61.6-1.81.6-1.9-2.10.3
Bone: marrow area0.20.50.91.0-0.50.8-0.6-0.40.6
Bone: maximum diameter0.00.10.20.4-0.30.4-0.1-0.10.4
Bone: maximum force0.00.00.1-0.00.10.20.10.20.4
Bone: maximum moment0.00.00.10.1-0.20.3-0.1-0.00.3
Mean time between licks in bursts0.21.31.6-1.01.2-1.01.31.2-1.2
Mean num. licks in bursts1.33.44.71.8-2.01.9-2.1-2.20.8
Cd content in liver0.30.40.7-0.80.7-0.70.50.5-0.3
Co content in liver2.83.36.01.8-1.51.8-1.7-1.52.4
Cu content in liver0.20.20.7-0.20.4-0.20.40.50.9
Fe content in liver1.92.32.81.6-1.41.7-1.5-1.31.5
K content in liver0.80.81.2-0.81.0-0.91.11.0-0.0
Mg content in liver0.00.00.1-0.10.2-0.20.20.1-0.0
Mn content in liver0.70.81.5-0.81.0-0.80.70.6-1.2
Na content in liver2.93.24.01.9-2.01.8-1.6-1.71.7
Rb content in liver0.30.30.5-0.70.5-0.70.60.6-0.3
Se content in liver0.30.40.6-0.70.8-0.70.50.5-0.3
Sr content in liver0.30.20.30.4-0.30.4-0.6-0.6-0.5
Zn content in liver1.41.72.3-1.31.3-1.41.51.5-0.2
Bone: minimum diameter0.91.82.8-1.31.4-1.31.51.7-0.5
Time in familiar zone, hab. session 11.41.62.1-1.31.4-1.31.21.3-0.9
Time in novel zone, hab. session 10.40.40.7-0.80.6-0.70.40.5-0.7
Total zone transitions, hab. session 10.70.91.51.2-0.91.2-0.6-0.61.1
Total locomotion distance, hab. session 11.31.82.31.5-1.41.5-1.1-1.01.4
Locomotion velocity, hab. session 12.43.44.42.0-2.02.1-1.6-1.61.8
Time in familiar zone, hab. session 20.30.41.5-0.50.5-0.50.20.1-1.2
Time in novel zone, hab. session 20.30.30.5-0.70.7-0.60.50.70.1
Total zone transitions, hab. session 20.10.10.40.6-0.40.5-0.1-0.00.0
Total locomotion distance, hab. session 20.10.10.30.5-0.30.30.10.10.0
Locomotion velocity, hab. session 20.10.20.40.7-0.50.50.00.00.4
Novel to familiar place preference ratio0.00.00.1-0.0-0.10.00.30.2-0.1
Novelty place preference0.10.20.4-0.30.2-0.30.60.5-0.2
Time in novel zone, NPP test0.20.30.5-0.50.4-0.50.70.7-0.3
Total zone transitions, NPP test0.91.32.61.3-1.01.2-0.8-0.61.6
Total locomotion distance, NPP test1.62.23.01.7-1.41.6-1.2-1.11.7
Locomotion velocity, NPP test2.63.64.72.2-1.92.1-1.5-1.52.2
Intraocular pressure3.35.46.9-2.62.4-2.52.01.8-2.6
Delta distance traveled before/after self-admin1.21.31.8-1.10.7-1.11.31.3-1.3
Delta ambulatory time before/after self-admin0.10.21.3-0.1-0.3-0.10.20.1-1.2
Parametrial fat weight24.357.267.5-8.18.2-7.88.17.8-4.8
Pavlov. Cond. lever latency0.50.61.7-0.70.7-0.80.40.1-1.3
Pavlov. Cond. magazine entry latency0.10.10.20.1-0.10.00.30.40.4
Pavlov. Cond. change in total contacts0.00.10.10.2-0.30.3-0.00.20.3
Pavlov. Cond. index score0.10.10.40.3-0.30.30.10.40.7
Pavlov. Cond. latency score0.10.10.30.3-0.20.30.10.30.5
Pavlov. Cond. lever contacts0.50.61.70.7-0.60.8-0.30.01.3
Pavlov. Cond. magazine entry number0.20.30.7-0.50.5-0.6-0.0-0.2-0.8
Pavlov. Cond. intertrial magazine entries0.70.81.40.7-0.70.7-1.2-1.20.9
Pavlov. Cond. lever-magazine prob. diff.0.30.41.10.6-0.60.6-0.20.01.0
Pavlov. Cond. response bias0.80.92.30.9-0.91.1-0.5-0.31.5
Pavlov. Cond. lever latency0.50.71.0-1.00.8-0.80.80.9-0.5
Pavlov. Cond. magazine entry latency0.00.00.1-0.00.2-0.20.1-0.0-0.2
Pavlov. Cond. change in total contacts0.00.00.10.30.10.1-0.2-0.20.1
Pavlov. Cond. index score0.20.40.60.7-0.50.5-0.7-0.80.3
Pavlov. Cond. latency score0.30.40.70.8-0.50.5-0.8-0.90.2
Pavlov. Cond. lever contacts0.20.30.50.7-0.50.5-0.5-0.50.4
Pavlov. Cond. magazine entry number0.20.20.50.4-0.70.6-0.4-0.30.3
Pavlov. Cond. intertrial magazine entries0.92.04.1-1.41.1-1.41.11.2-2.0
Pavlov. Cond. lever-magazine prob. diff.0.10.10.30.4-0.20.2-0.5-0.5-0.0
Pavlov. Cond. response bias0.40.50.91.0-0.60.7-0.7-0.70.7
Time in closed arm before self-admin0.10.20.6-0.40.5-0.40.60.70.1
Time in closed arm after self-admin1.11.32.0-1.21.0-1.21.21.4-0.1
Time in open arm before self-admin0.10.10.20.10.10.1-0.2-0.4-0.5
Time in open arm after self-admin0.10.20.30.5-0.30.6-0.4-0.40.2
Bone: periosteal estimation0.20.40.70.9-0.40.8-0.4-0.30.8
Bone: periosteal perimeter0.00.10.30.1-0.10.10.10.20.6
Bone: post-yield work1.01.72.11.4-1.21.4-1.5-1.31.2
Progressive ratio test 1 active lever presses1.32.35.01.5-1.31.7-1.1-0.92.2
Progressive ratio test 1 breakpoint1.42.45.01.5-1.41.7-1.1-1.02.2
Progressive ratio test 1 inactive lever presses1.43.59.01.8-1.71.9-1.3-0.93.0
Progressive ratio test 2 active lever presses2.84.04.62.1-2.12.1-2.1-1.91.5
Progressive ratio test 2 breakpoint3.03.84.62.1-2.12.1-2.0-1.91.4
Progressive ratio test 2 inactive lever presses1.75.57.02.4-2.62.5-2.5-2.31.6
Incentive Sensitization - Responses1.13.24.71.8-1.91.6-2.2-2.00.8
Incentive Sensitization - Breakpoint1.22.74.31.6-1.81.5-2.1-2.00.5
Sum of active levers in priming session hrs 5-60.10.10.20.0-0.10.10.50.4-0.2
Progressive ratio0.10.20.6-0.20.5-0.40.50.80.0
Food seeking constrained by brief footshock8.810.917.13.4-3.03.2-3.2-2.74.1
Seeking ratio, punishment vs. effort1.12.53.31.5-1.61.6-1.7-1.81.2
Retroperitoneal fat weight39.4176.4205.4-14.314.0-14.313.312.9-10.5
Reaction time number correct0.20.60.90.9-1.00.7-0.7-0.50.7
Reaction time mean minus median0.31.72.7-1.51.5-1.61.11.3-0.1
Reaction time mean minus median AUC0.21.41.9-1.21.3-1.41.31.40.1
Reaction time num false alarms1.83.04.1-1.71.7-1.82.02.0-0.6
Reaction time num false alarms AUC1.22.74.0-1.61.6-1.72.02.0-0.5
Reaction time trials correct on left0.20.60.90.9-1.00.7-0.7-0.50.7
Reaction time trials on left0.10.50.70.8-0.90.6-0.6-0.40.8
Reaction time mean0.20.50.8-0.70.7-0.90.70.6-0.5
Reaction time mean AUC0.10.20.4-0.50.5-0.60.50.5-0.2
Median of all reaction times0.00.10.2-0.20.1-0.30.20.0-0.5
Reaction time omissions1.52.45.0-1.11.6-1.11.92.20.9
Reaction time false alarm rate2.63.54.4-2.02.0-2.02.12.0-1.1
Reaction time premature initiation rate0.00.10.30.10.00.2-0.1-0.2-0.6
Reaction time premature initiations0.10.30.40.6-0.60.6-0.6-0.6-0.1
Std. dev. reaction times0.51.82.7-1.41.5-1.61.41.4-0.3
Reaction time trials completed0.10.50.70.8-0.90.6-0.6-0.40.8
Reaction time trials AUC0.10.40.70.7-0.80.6-0.5-0.40.9
Run reversals in cocaine runway, females0.80.91.30.9-1.10.8-1.0-1.10.5
Run reversals in cocaine runway, males0.91.01.61.0-1.31.0-0.8-0.61.2
Latency to leave start box in cocaine runway0.20.20.70.3-0.10.4-0.8-0.80.1
Latency to leave start box in cocaine runway, F0.20.20.4-0.60.7-0.50.10.1-0.4
Latency to leave start box in cocaine runway, M1.11.11.80.9-1.01.0-1.2-1.30.5
Std. dev. time between licks in bursts0.20.40.6-0.50.7-0.30.80.7-0.8
Total sessions with >9 infusions2.22.73.81.9-1.71.7-1.6-1.51.5
Short access day 1 total inactive lever presses3.05.98.62.8-2.92.6-2.0-1.72.4
Short access day 10 total inactive lever presses0.10.62.30.6-0.70.7-0.10.31.5
Short access day 1 total infusions1.52.93.61.7-1.91.6-1.7-1.51.9
Short access day 10 total infusions1.82.93.91.7-2.01.5-1.6-1.42.0
Short access total infusions1.31.93.01.4-1.41.3-1.2-1.01.7
Short access day 1 locomotion1.01.74.41.3-1.21.2-1.0-0.62.1
Short access day 10 total locomotion0.52.22.81.7-1.41.6-1.5-1.31.4
Short access total locomotion1.62.43.11.8-1.41.7-1.5-1.51.3
One hour access (0.3 mA shock)4.85.78.02.2-2.82.4-2.8-2.80.6
Compulsive drug intake1.01.57.2-0.80.2-0.70.50.2-2.7
One hour access (shock baseline)2.36.16.82.5-2.62.6-2.6-2.32.3
Social response proportion0.30.30.9-0.70.5-0.5-0.3-0.3-0.9
Social responses0.40.51.0-1.00.8-0.70.60.5-0.7
Social time0.00.10.1-0.30.3-0.3-0.1-0.2-0.2
Soleus weight3.710.913.53.7-3.63.6-3.2-3.02.6
Bone: stiffness0.00.10.2-0.10.1-0.00.40.50.1
Tibialis anterior weight1.34.45.32.3-2.22.3-2.0-2.01.8
Time to tail flick, vehicle, before self-admin0.50.61.8-0.20.3-0.20.81.11.3
Time to tail flick, vehicle, after self-admin3.77.59.3-3.03.1-2.92.92.8-1.6
Time to tail flick, test, before self-admin0.20.20.40.4-0.20.5-0.4-0.10.7
Time to tail flick, test, after self-admin1.11.21.41.1-1.01.2-1.1-0.91.1
Delta time to tail flick, vehicle, before/after SA1.71.92.6-1.51.4-1.41.21.0-1.6
Delta time to tail flick, test, before/after SA2.02.54.31.4-1.61.4-1.9-2.10.6
Tibia length0.61.62.1-1.41.1-1.31.21.2-1.4
Ambulatory time before self-admin0.00.10.50.40.10.2-0.1-0.10.7
Ambulatory time after self-admin0.10.10.5-0.0-0.2-0.20.20.1-0.7
Bone: tissue strength0.30.40.7-0.70.3-0.60.60.5-0.9
Total heroin consumption4.65.47.22.6-2.42.5-2.5-2.70.7
Bone: trabecular number2.24.14.72.1-2.22.1-1.9-1.72.1
Bone: trabecular spacing0.30.40.7-0.50.7-0.50.80.6-0.6
Bone: trabecular thickness0.10.10.3-0.00.10.0-0.3-0.10.6
Bone: trabecular tissue density0.00.10.20.3-0.30.1-0.2-0.20.5
Water consumed over 24 hours0.00.10.2-0.00.30.00.50.4-0.1
Number of responses in last shaping day1.01.21.61.0-1.11.0-1.2-1.31.0