Hub : Genes

Ncoa1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA alternative TSS NM_001395569.1 0.06 0.05 6.0e-03 0.03 0.03 0.02 0.03 1.4e-02 1.6e-02 4.6e-02 2.4e-02
2 pVTA alternative TSS NM_001395569.1 0.07 0.06 5.4e-03 0.04 0.03 0.02 0.03 1.2e-02 1.8e-02 3.7e-02 2.5e-02
3 PL intron excision ratio chr6_27234917_27235003 0.04 0.05 6.8e-04 0.03 0.02 0.01 0.03 1.9e-04 9.3e-04 4.4e-02 4.0e-04
4 OFC alternative TSS NM_001395569.1 0.11 0.1 5.2e-03 0.06 0.1 0.07 0.05 1.4e-02 2.8e-03 9.8e-03 2.9e-02
5 OFC alternative TSS NM_001395569.1 0.12 0.1 4.2e-03 0.06 0.1 0.07 0.05 1.2e-02 2.1e-03 8.1e-03 2.4e-02
6 Brain gene expression Ncoa1 0.41 0 5.0e-16 0.16 0.15 0.16 0.17 3.8e-15 3.9e-14 2.5e-14 8.3e-16
7 PL intron excision ratio chr6_27234914_27235003 0.03 0.03 2.0e-03 0.02 0.02 0.01 0.02 4.0e-03 2.4e-03 1.6e-02 5.2e-03
8 Liver gene expression Ncoa1 0.02 0.02 5.6e-03 0.01 0.01 0.01 0 4.1e-02 6.4e-02 6.7e-02 1.2e-01
9 BLA mRNA stability Ncoa1 0.2 0.1 1.3e-03 0.03 0.05 0.04 0.03 7.2e-03 1.6e-03 2.2e-03 8.8e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density3.66.07.7-2.7-2.7-2.8-2.5-2.4-2.3-2.3-2.1-2.3
Area under the delay curve0.00.00.10.10.10.30.10.10.10.10.00.1
BMI with tail4.013.015.33.63.63.93.63.63.83.73.33.4
BMI without tail1.42.84.71.41.41.71.71.71.81.52.21.4
Body weight3.815.816.74.14.14.14.04.04.14.03.93.7
Weight adjusted by age1.82.03.01.61.61.21.31.31.21.41.41.7
Bone surface1.01.82.4-1.5-1.5-1.5-1.3-1.3-1.1-1.1-1.4-1.1
Bone volume2.23.84.7-2.1-2.1-2.2-2.0-2.0-1.8-1.8-1.8-1.7
Breakpoint value in progressive ratio session1.41.62.7-1.0-1.0-1.4-1.3-1.2-1.6-1.1-1.4-1.1
Number of licking bursts1.92.23.11.41.41.41.51.51.71.41.61.3
Context. condit. distance diff. score0.10.20.2-0.5-0.5-0.4-0.4-0.4-0.3-0.2-0.4-0.5
Locomotion velocity, session 10.20.20.90.10.10.10.50.50.50.30.90.1
Locomotion distance, session 10.60.81.3-1.1-1.1-1.1-0.9-0.9-0.8-0.9-0.3-0.6
Locomotion velocity, session 20.50.60.80.70.70.80.70.70.90.80.50.8
Locomotion distance, session 20.00.00.1-0.1-0.1-0.1-0.0-0.00.1-0.00.40.3
Locomotion velocity, session 30.00.00.10.00.00.10.10.10.00.10.4-0.2
Locomotion distance, session 30.00.00.00.10.10.10.00.00.10.00.2-0.1
Stereotopy head waving bouts, day 32.93.44.6-1.7-1.7-1.9-1.7-1.7-2.1-1.7-1.8-2.2
Stereotopy head waving duration, day 30.50.61.2-0.6-0.6-0.8-0.7-0.7-1.0-0.7-0.7-1.1
Locomotion velocity, session 70.10.10.20.50.50.50.10.10.20.4-0.30.4
Locomotion distance, session 71.01.32.01.41.41.31.01.00.81.20.70.9
Stereotopy head waving bouts, day 70.10.10.2-0.4-0.4-0.5-0.1-0.20.1-0.30.2-0.1
Stereotopy head waving duration, day 70.40.50.8-0.9-0.9-0.9-0.6-0.6-0.4-0.7-0.2-0.6
Locomotion velocity, session 80.30.30.4-0.7-0.7-0.6-0.6-0.6-0.6-0.4-0.5-0.6
Locomotion distance, session 81.01.51.8-1.3-1.3-1.2-1.3-1.3-1.2-1.1-1.0-1.0
Degree of sensitization distance1.41.41.91.41.41.31.21.21.01.30.81.0
Degree of sensitization stereotypy0.30.41.00.30.30.30.50.50.90.41.00.7
Conditioned locomotion2.12.42.9-1.7-1.7-1.7-1.6-1.6-1.5-1.5-1.3-1.5
Cocaine response after cond. corrected0.10.10.2-0.4-0.4-0.3-0.2-0.2-0.1-0.40.2-0.1
Cocaine response after cond. not corrected0.50.61.0-1.0-1.0-0.9-0.7-0.7-0.6-0.9-0.3-0.5
Cocaine response before conditioning1.62.02.4-1.4-1.4-1.4-1.4-1.4-1.4-1.4-1.6-1.2
Saline control response1.92.62.9-1.7-1.7-1.7-1.6-1.6-1.6-1.6-1.5-1.4
Bone: connectivity density2.13.34.6-2.0-2.0-2.1-1.8-1.8-1.7-1.6-1.4-1.7
Bone: cortical apparent density0.10.10.2-0.4-0.4-0.4-0.3-0.3-0.4-0.5-0.0-0.4
Bone: cortical area0.00.00.1-0.0-0.00.10.20.20.30.10.30.3
Bone: cortical porosity1.92.02.5-1.4-1.4-1.5-1.6-1.6-1.5-1.4-1.2-1.1
Bone: cortical porosity1.31.41.9-1.2-1.2-1.2-1.4-1.4-1.3-1.2-1.1-0.8
Bone: cortical thickness0.10.20.30.40.40.40.40.40.50.20.50.6
Bone: cortical thickness0.60.81.2-0.7-0.7-0.7-1.0-1.0-1.0-0.9-1.1-0.7
Bone: cortical tissue density0.10.10.1-0.3-0.3-0.3-0.2-0.2-0.3-0.40.1-0.3
Condit. Reinf. active minus inactive responses3.13.54.81.81.81.91.91.91.91.72.21.7
Condit. Reinf. active-inactive response ratio2.52.73.21.71.71.81.81.81.51.61.81.2
Condit. Reinf. active responses0.50.61.10.60.60.70.70.70.80.71.10.8
Condit. Reinf. inactive responses1.31.51.9-1.4-1.4-1.3-1.4-1.3-1.1-1.1-1.1-0.8
Incentive salience index mean1.11.32.30.90.91.11.11.11.21.01.51.2
Condit. Reinf. lever presses0.20.30.8-0.9-0.9-0.7-0.5-0.5-0.1-0.50.1-0.0
Condit. Reinf. active minus inactive responses0.70.91.1-1.0-1.0-0.9-0.9-0.9-1.1-1.0-0.6-1.1
Condit. Reinf. active-inactive response ratio0.20.20.4-0.6-0.6-0.5-0.4-0.4-0.3-0.5-0.1-0.4
Condit. Reinf. active responses0.40.60.8-0.9-0.9-0.8-0.7-0.7-0.8-0.9-0.2-0.7
Condit. Reinf. inactive responses0.10.20.2-0.5-0.5-0.5-0.4-0.4-0.4-0.50.0-0.3
Condit. Reinf. lever presses0.71.01.3-1.0-1.0-0.9-1.0-1.0-1.1-1.1-0.7-1.1
Condit. Reinf. lever reinforcers received0.40.50.7-0.8-0.8-0.7-0.7-0.7-0.8-0.8-0.3-0.6
Conditioned reinforcement - actives4.04.04.6-1.9-1.9-2.1-2.1-2.1-2.0-2.1-2.1-1.7
Conditioned reinforcement - inactives6.97.89.1-3.0-3.0-3.0-2.9-2.9-2.6-2.9-2.5-2.2
Conditioned locomotion4.14.97.6-1.9-1.9-1.8-2.4-2.4-2.7-2.2-2.8-1.4
Patch foraging indifference point 0 sec0.00.10.10.30.30.10.30.30.20.2-0.2-0.2
Patch foraging indifference point AUC0.00.00.2-0.2-0.2-0.00.00.00.00.00.5-0.2
Delay disc. indifference point, 0s delay0.00.00.20.00.00.20.20.20.40.00.20.2
Delay disc. indifference point, 16s delay0.00.00.00.10.10.0-0.0-0.0-0.1-0.0-0.00.1
Delay disc. indifference point, 2s delay0.00.00.20.20.20.5-0.0-0.0-0.10.1-0.20.1
Delay disc. indifference point, 24s delay2.22.12.7-1.6-1.6-1.3-1.6-1.6-1.5-1.4-1.4-0.9
Delay disc. indifference point, 4s delay0.00.00.10.30.30.10.10.10.00.1-0.1-0.0
Delay disc. indifference point, 8s delay0.00.00.0-0.2-0.20.0-0.0-0.0-0.00.1-0.10.0
Indifference point function ln k2.02.73.1-1.7-1.7-1.7-1.7-1.7-1.6-1.7-1.8-1.3
Indifference point function log k2.02.73.1-1.7-1.7-1.7-1.7-1.7-1.6-1.7-1.8-1.3
Patch foraging total patch changes 0 sec0.00.00.10.20.2-0.00.20.20.10.1-0.3-0.3
Patch foraging total patch changes 12 sec1.31.72.11.31.31.31.41.41.31.31.50.9
Patch foraging total patch changes 18 sec0.20.30.50.50.50.50.70.70.40.60.3-0.2
Patch foraging total patch changes 24 sec0.50.60.90.60.60.60.80.80.90.71.00.6
Patch foraging total patch changes 6 sec0.91.41.61.21.21.11.31.31.21.21.30.6
Patch foraging time to switch 0 sec0.81.22.01.41.41.31.11.10.81.10.60.8
Patch foraging water rate 0 sec3.25.16.5-2.5-2.5-2.5-2.3-2.3-2.1-2.2-1.9-1.9
Patch foraging water rate 12 sec0.00.00.1-0.1-0.1-0.2-0.1-0.1-0.1-0.20.30.3
Patch foraging water rate 18 sec3.44.55.9-2.2-2.2-2.4-2.3-2.3-2.0-2.4-1.7-1.5
Patch foraging water rate 24 sec0.00.10.10.40.40.20.20.20.10.20.10.1
Patch foraging water rate 6 sec1.11.62.4-1.3-1.3-1.6-1.3-1.3-1.3-1.5-0.7-1.0
Seeking ratio, delayed vs. immediate footshock0.30.40.60.50.50.80.70.70.70.60.50.1
Distance traveled before self-admin0.10.10.3-0.1-0.1-0.0-0.1-0.1-0.4-0.2-0.2-0.6
Distance traveled after self-admin0.00.00.20.10.1-0.2-0.0-0.0-0.3-0.00.1-0.4
Extensor digitorum longus weight1.76.77.6-2.7-2.7-2.8-2.7-2.7-2.6-2.7-2.0-2.4
Bone: elastic displacement2.02.32.9-1.5-1.5-1.7-1.6-1.6-1.7-1.6-1.1-1.4
Bone: elastic work1.41.82.3-1.2-1.2-1.4-1.4-1.4-1.4-1.4-1.5-1.2
Bone: endosteal estimation0.20.40.6-0.8-0.8-0.6-0.6-0.6-0.5-0.5-0.7-0.7
Bone: endosteal perimeter0.00.00.1-0.1-0.10.10.20.20.30.20.0-0.0
Epididymis fat weight23.654.960.37.77.77.87.67.67.37.66.66.7
Delta time in closed arm before/after self-admin0.30.30.70.80.80.20.50.50.40.50.40.3
Delta time in open arm before/after self-admin0.20.20.3-0.1-0.10.60.30.30.60.40.50.3
Diff in mean of infusions in LGA sessions0.30.30.70.10.10.40.50.50.70.60.80.8
Delay discount exponential model param0.00.00.00.00.0-0.10.10.10.10.00.2-0.0
Extinction: sum of active levers before priming0.00.00.20.10.1-0.2-0.0-0.00.10.10.00.4
Active lever presses in extinction session 60.20.20.7-0.8-0.8-0.4-0.3-0.3-0.2-0.30.6-0.0
Bone: final force0.10.10.20.40.40.30.30.30.50.30.10.4
Bone: final moment0.00.10.10.20.20.20.20.20.30.20.10.2
Food consumed during 24 hour testing period0.10.10.2-0.5-0.5-0.4-0.3-0.3-0.1-0.30.1-0.3
Glucose0.20.30.80.50.50.60.60.60.30.50.90.1
Heart weight3.95.66.22.52.52.42.52.52.32.42.02.2
Delay discount hyperbolic model param0.00.00.0-0.0-0.0-0.10.10.10.10.00.2-0.0
Intermittent access intake day 1-15 change5.25.26.9-1.9-1.9-2.2-2.3-2.3-2.4-2.4-2.4-2.6
Intermittent access intake escalation3.93.86.4-1.5-1.5-1.9-1.9-1.9-2.0-2.0-2.1-2.5
Intermittent access intake escalation 20.90.92.6-0.3-0.3-0.6-0.8-0.8-1.2-0.9-1.2-1.6
Intermitt. access day 1 inactive lever presses0.10.10.1-0.4-0.4-0.3-0.2-0.20.3-0.30.20.0
Intermitt. access day 15 inactive lever presses0.91.02.0-1.3-1.3-1.4-0.8-0.8-0.5-1.1-0.2-0.9
Intermitt. access escalation Index2.11.92.71.61.61.51.41.41.01.40.91.3
Intermittent access day 1 total infusions1.61.92.8-1.7-1.7-1.5-1.4-1.4-1.2-1.3-1.1-0.6
Intermittent access day 15 total infusions3.94.44.9-2.0-2.0-2.2-2.1-2.1-2.1-2.2-2.1-2.0
Intermittent access terminal intake (last 3 days)3.13.44.2-1.8-1.8-1.8-1.9-1.9-1.9-2.0-2.0-1.5
Intermittent access total infusions2.22.42.8-1.6-1.6-1.6-1.7-1.7-1.6-1.6-1.6-0.9
Intermittent access day 1 locomotion2.72.83.3-1.8-1.8-1.6-1.8-1.8-1.8-1.7-1.6-0.9
Intermittent access day 15 total locomotion0.80.81.0-0.9-0.9-1.0-0.9-0.9-1.0-1.0-0.9-0.8
Intermittent access total locomotion1.01.21.7-1.0-1.0-0.9-1.2-1.2-1.3-1.1-1.3-0.3
Intermittent access standard deviation0.70.82.1-0.7-0.7-0.8-0.7-0.7-0.9-0.9-0.7-1.4
Left kidney weight0.10.20.3-0.5-0.5-0.5-0.5-0.5-0.6-0.5-0.3-0.2
Right kidney weight0.61.72.21.51.51.21.41.41.21.31.21.1
Cocaine induced anxiety0.80.91.4-0.7-0.7-1.1-0.9-0.8-1.1-0.9-1.2-1.1
Post-drug Anxiety0.10.10.3-0.0-0.00.10.40.40.50.40.50.2
Baseline Anxiety1.01.11.90.70.71.01.11.01.31.01.40.9
Tail length0.20.71.0-0.9-0.9-1.0-0.8-0.8-0.8-0.9-0.2-0.8
Length with tail0.10.50.90.80.80.50.70.70.70.60.90.8
Length without tail0.30.60.90.90.90.70.60.60.70.80.21.0
Times rat made contact with spout0.91.01.3-1.1-1.1-1.0-1.1-1.0-0.9-0.8-1.1-0.9
Lifetime Intake2.62.93.4-1.8-1.8-1.8-1.8-1.8-1.8-1.8-1.6-1.2
Liver weight, left1.42.24.31.41.41.31.41.41.51.22.11.4
Liver weight, right4.88.09.02.72.72.92.92.93.02.92.72.6
Locomotor activity2.54.05.51.91.91.92.02.02.21.82.31.8
Locomotor testing distance1.72.85.61.41.41.41.81.81.91.52.41.4
Locomotor testing rearing0.10.20.80.20.20.30.40.40.40.30.90.6
Locomotion in novel chamber1.82.23.51.31.31.51.41.41.61.31.61.9
Locomotion in novel chamber post-restriction0.60.81.11.01.00.90.90.90.50.90.61.1
Fecal boli incidents, locomotor time 14.14.44.9-2.1-2.1-2.1-2.2-2.2-2.0-2.1-2.2-1.9
Change in fecal boli incidents, locomotor task3.43.26.12.52.51.61.91.91.21.71.21.1
Time >=10cm from walls, locomotor time 10.20.20.5-0.3-0.3-0.5-0.3-0.3-0.5-0.3-0.7-0.5
Bouts of movement, locomotor time 10.60.61.2-1.1-1.1-0.8-0.7-0.7-0.4-0.7-0.5-0.6
Total resting periods, locomotor time 10.80.91.5-1.2-1.2-1.1-0.9-0.9-0.6-0.8-0.7-0.8
Rest time, locomotor task time 10.40.40.6-0.8-0.8-0.6-0.6-0.6-0.6-0.6-0.6-0.5
Distance moved, locomotor task time 11.11.21.71.21.21.21.11.11.01.11.01.3
Vertical activity count, locomotor time 10.10.10.30.50.50.50.30.30.20.20.10.3
Time >=10cm from walls, locomotor time 21.31.42.7-0.9-0.9-1.0-1.1-1.1-1.3-1.0-1.6-1.4
Bouts of movement, locomotor time 20.00.00.00.20.2-0.2-0.1-0.10.0-0.1-0.2-0.1
Total resting periods, locomotor time 20.00.00.00.20.2-0.2-0.1-0.10.1-0.0-0.2-0.1
Rest time, locomotor task time 20.00.00.1-0.3-0.3-0.2-0.1-0.10.1-0.1-0.1-0.2
Distance moved, locomotor task time 20.00.00.1-0.0-0.00.2-0.0-0.0-0.2-0.1-0.20.3
Vertical activity count, locomotor time 20.10.20.4-0.3-0.3-0.3-0.3-0.3-0.6-0.4-0.6-0.2
Light reinforcement 10.61.11.9-1.4-1.4-1.3-0.9-0.9-0.8-1.20.0-0.9
Light reinforcement 23.14.14.6-2.1-2.1-2.2-2.0-2.0-2.1-2.1-1.9-1.7
Bone: marrow area0.20.40.6-0.8-0.8-0.6-0.6-0.6-0.5-0.5-0.7-0.6
Bone: maximum diameter0.10.10.3-0.5-0.5-0.4-0.2-0.2-0.1-0.3-0.3-0.4
Bone: maximum force0.00.10.10.20.20.20.30.30.30.2-0.00.3
Bone: maximum moment0.00.00.00.10.10.10.10.10.20.1-0.10.1
Mean time between licks in bursts1.31.92.21.31.31.41.51.51.51.51.31.1
Mean num. licks in bursts3.13.74.6-1.8-1.8-1.9-2.0-2.0-2.1-1.7-2.2-1.7
Cd content in liver0.00.00.10.10.10.20.10.10.00.20.30.0
Co content in liver2.63.03.6-1.9-1.9-1.7-1.9-1.9-1.6-1.8-1.7-1.1
Cu content in liver0.91.11.31.01.01.11.01.01.01.21.00.9
Fe content in liver0.40.40.7-0.6-0.6-0.6-0.7-0.7-0.8-0.5-0.5-0.8
K content in liver2.72.63.21.71.71.81.71.71.61.61.51.4
Mg content in liver1.31.41.91.31.31.41.21.21.11.21.00.8
Mn content in liver0.00.10.10.30.30.40.00.00.00.1-0.10.3
Na content in liver3.53.74.4-2.1-2.1-2.0-1.9-2.0-1.9-2.1-1.5-1.7
Rb content in liver0.60.71.00.80.80.81.01.00.71.00.90.4
Se content in liver0.91.11.71.31.31.21.01.00.91.00.80.8
Sr content in liver0.00.00.10.20.20.30.00.00.10.1-0.10.1
Zn content in liver4.95.56.82.22.22.32.42.42.62.22.52.3
Bone: minimum diameter0.91.62.41.11.11.21.31.31.51.31.21.3
Time in familiar zone, hab. session 11.91.82.11.41.41.51.31.31.41.41.01.4
Time in novel zone, hab. session 10.30.30.40.70.70.60.60.60.40.60.60.2
Total zone transitions, hab. session 10.40.61.0-1.0-1.0-0.9-0.8-0.8-0.7-0.7-0.4-0.5
Total locomotion distance, hab. session 11.11.62.1-1.4-1.4-1.5-1.3-1.3-1.1-1.4-0.7-1.0
Locomotion velocity, hab. session 12.33.34.3-2.0-2.0-2.1-1.9-1.9-1.6-2.0-1.2-1.5
Time in familiar zone, hab. session 20.20.20.30.50.50.50.40.40.30.40.10.2
Time in novel zone, hab. session 20.40.40.50.70.70.70.60.60.50.70.60.4
Total zone transitions, hab. session 20.10.10.2-0.5-0.5-0.3-0.2-0.2-0.1-0.1-0.1-0.0
Total locomotion distance, hab. session 20.00.10.1-0.4-0.4-0.4-0.1-0.10.0-0.00.1-0.2
Locomotion velocity, hab. session 20.10.10.3-0.5-0.5-0.5-0.2-0.2-0.1-0.20.0-0.3
Novel to familiar place preference ratio0.00.00.0-0.1-0.1-0.2-0.1-0.1-0.0-0.20.2-0.1
Novelty place preference0.10.10.40.20.20.10.20.20.30.10.60.2
Time in novel zone, NPP test0.10.10.40.40.40.30.30.30.40.30.60.3
Total zone transitions, NPP test0.40.61.0-1.0-1.0-0.9-0.8-0.8-0.6-0.7-0.2-0.6
Total locomotion distance, NPP test1.21.62.2-1.5-1.5-1.5-1.3-1.2-1.1-1.1-0.9-1.1
Locomotion velocity, NPP test2.02.84.0-2.0-2.0-2.0-1.6-1.6-1.5-1.7-1.0-1.5
Intraocular pressure3.65.07.02.62.62.52.32.31.92.31.81.8
Delta distance traveled before/after self-admin0.91.01.31.11.10.80.90.91.01.01.20.9
Delta ambulatory time before/after self-admin0.00.00.00.20.2-0.1-0.00.00.10.1-0.00.0
Parametrial fat weight14.929.132.45.55.55.55.55.55.45.15.75.0
Pavlov. Cond. lever latency0.20.20.50.70.70.60.40.40.10.30.10.1
Pavlov. Cond. magazine entry latency0.20.20.50.10.10.20.40.40.70.60.70.5
Pavlov. Cond. change in total contacts0.10.10.1-0.3-0.3-0.2-0.3-0.30.1-0.1-0.20.2
Pavlov. Cond. index score0.00.10.2-0.3-0.3-0.2-0.0-0.00.40.10.20.3
Pavlov. Cond. latency score0.00.00.2-0.3-0.3-0.20.00.00.40.20.10.2
Pavlov. Cond. lever contacts0.20.20.6-0.7-0.7-0.6-0.4-0.4-0.1-0.3-0.1-0.1
Pavlov. Cond. magazine entry number0.10.10.20.40.40.30.10.1-0.3-0.0-0.4-0.1
Pavlov. Cond. intertrial magazine entries0.81.01.8-0.7-0.7-0.8-1.1-1.1-1.3-1.0-1.3-1.0
Pavlov. Cond. lever-magazine prob. diff.0.20.20.6-0.7-0.7-0.6-0.5-0.5-0.1-0.3-0.2-0.1
Pavlov. Cond. response bias0.60.71.2-1.1-1.1-1.0-0.9-0.9-0.5-0.7-0.5-0.5
Pavlov. Cond. lever latency0.60.91.10.90.90.81.01.01.10.91.00.9
Pavlov. Cond. magazine entry latency0.00.00.10.20.20.20.00.0-0.20.10.0-0.3
Pavlov. Cond. change in total contacts0.00.00.1-0.0-0.00.1-0.2-0.2-0.40.0-0.1-0.2
Pavlov. Cond. index score0.30.40.8-0.5-0.5-0.4-0.7-0.7-0.9-0.6-0.7-0.8
Pavlov. Cond. latency score0.40.50.9-0.5-0.5-0.5-0.7-0.7-0.9-0.6-0.8-0.8
Pavlov. Cond. lever contacts0.10.10.2-0.2-0.2-0.1-0.3-0.3-0.4-0.2-0.2-0.3
Pavlov. Cond. magazine entry number0.30.30.7-0.7-0.7-0.8-0.5-0.6-0.2-0.7-0.3-0.2
Pavlov. Cond. intertrial magazine entries1.01.41.81.31.31.11.21.21.31.00.81.1
Pavlov. Cond. lever-magazine prob. diff.0.10.20.5-0.2-0.2-0.2-0.4-0.4-0.7-0.3-0.5-0.6
Pavlov. Cond. response bias0.20.20.4-0.5-0.5-0.3-0.5-0.5-0.7-0.4-0.5-0.5
Time in closed arm before self-admin0.00.00.1-0.3-0.3-0.0-0.0-0.0-0.1-0.10.1-0.3
Time in closed arm after self-admin1.01.01.70.90.90.70.90.91.10.81.31.3
Time in open arm before self-admin0.00.00.10.30.30.30.10.10.10.1-0.20.1
Time in open arm after self-admin0.20.30.5-0.6-0.6-0.2-0.4-0.4-0.4-0.4-0.6-0.7
Bone: periosteal estimation0.10.30.5-0.7-0.7-0.5-0.5-0.5-0.3-0.5-0.5-0.5
Bone: periosteal perimeter0.00.00.1-0.2-0.2-0.10.10.10.20.1-0.00.0
Bone: post-yield work0.71.01.4-1.0-1.0-0.9-1.0-1.0-1.1-0.8-1.2-0.9
Progressive ratio test 1 active lever presses0.91.01.9-1.4-1.4-1.0-1.0-1.1-0.8-0.9-0.30.2
Progressive ratio test 1 breakpoint0.80.81.6-1.3-1.3-0.9-1.0-1.0-0.7-0.9-0.40.4
Progressive ratio test 1 inactive lever presses2.12.33.0-1.7-1.7-1.7-1.6-1.6-1.4-1.6-1.2-1.2
Progressive ratio test 2 active lever presses2.22.32.9-1.5-1.5-1.4-1.7-1.7-1.7-1.5-1.7-1.1
Progressive ratio test 2 breakpoint2.22.53.2-1.5-1.5-1.4-1.7-1.7-1.8-1.6-1.8-1.1
Progressive ratio test 2 inactive lever presses4.24.95.2-2.3-2.3-2.2-2.2-2.2-2.2-2.2-2.1-2.3
Incentive Sensitization - Responses2.22.24.1-1.1-1.1-1.1-1.5-1.5-1.7-1.5-2.0-1.6
Incentive Sensitization - Breakpoint1.71.73.4-0.9-0.9-0.9-1.3-1.3-1.5-1.3-1.9-1.4
Sum of active levers in priming session hrs 5-60.10.10.2-0.4-0.4-0.5-0.2-0.2-0.2-0.1-0.0-0.2
Progressive ratio0.10.10.30.00.00.50.30.30.50.40.1-0.2
Food seeking constrained by brief footshock7.69.411.1-3.3-3.3-3.0-3.1-3.1-2.9-2.9-3.0-3.0
Seeking ratio, punishment vs. effort1.92.33.0-1.4-1.4-1.7-1.6-1.6-1.7-1.6-1.4-1.3
Retroperitoneal fat weight37.6123.7136.711.711.711.411.511.410.811.010.79.8
Reaction time number correct0.30.50.8-0.9-0.9-0.9-0.7-0.7-0.5-0.7-0.5-0.4
Reaction time mean minus median1.62.12.61.31.31.51.61.61.61.41.61.2
Reaction time mean minus median AUC1.41.93.41.01.01.31.51.51.61.31.91.2
Reaction time num false alarms2.53.44.21.71.71.71.91.92.01.82.01.6
Reaction time num false alarms AUC2.23.03.91.51.51.61.81.81.91.72.01.7
Reaction time trials correct on left0.30.50.8-0.9-0.9-0.9-0.7-0.7-0.5-0.7-0.5-0.4
Reaction time trials on left0.30.40.6-0.8-0.8-0.8-0.6-0.6-0.4-0.6-0.4-0.3
Reaction time mean0.20.30.40.50.50.60.60.60.50.50.50.4
Reaction time mean AUC0.10.10.20.30.30.40.50.40.40.40.40.4
Median of all reaction times0.00.00.1-0.1-0.1-0.1-0.1-0.1-0.2-0.1-0.3-0.2
Reaction time omissions1.11.53.20.50.51.01.31.31.71.11.81.0
Reaction time false alarm rate2.73.73.92.02.01.92.02.02.01.92.01.7
Reaction time premature initiation rate0.00.00.1-0.1-0.10.1-0.1-0.1-0.10.0-0.3-0.2
Reaction time premature initiations0.20.30.5-0.7-0.7-0.5-0.5-0.5-0.5-0.5-0.6-0.6
Std. dev. reaction times1.52.02.71.21.21.41.61.61.61.41.61.1
Reaction time trials completed0.30.40.6-0.8-0.8-0.8-0.6-0.6-0.4-0.6-0.4-0.3
Reaction time trials AUC0.20.30.5-0.7-0.7-0.7-0.5-0.5-0.4-0.5-0.3-0.2
Run reversals in cocaine runway, females0.90.91.4-0.7-0.7-1.1-0.9-0.9-0.9-0.9-1.1-1.2
Run reversals in cocaine runway, males1.61.62.3-1.5-1.5-1.5-1.3-1.3-0.9-1.4-0.7-0.8
Latency to leave start box in cocaine runway0.20.20.7-0.1-0.1-0.1-0.1-0.1-0.80.0-0.4-0.8
Latency to leave start box in cocaine runway, F0.10.10.30.40.40.40.40.4-0.20.50.30.1
Latency to leave start box in cocaine runway, M1.41.32.2-1.1-1.1-1.0-1.1-1.0-1.4-0.9-1.2-1.5
Std. dev. time between licks in bursts0.10.10.30.30.30.50.40.40.40.50.30.2
Total sessions with >9 infusions4.04.45.5-2.3-2.3-2.3-2.3-2.3-2.1-2.2-1.7-1.0
Short access day 1 total inactive lever presses2.32.53.5-1.8-1.8-1.9-1.7-1.7-1.4-1.7-1.2-0.9
Short access day 10 total inactive lever presses0.50.61.30.50.50.50.70.81.10.71.10.3
Short access day 1 total infusions1.81.92.9-1.3-1.3-1.4-1.4-1.4-1.7-1.4-1.4-1.1
Short access day 10 total infusions3.33.75.0-1.8-1.8-2.2-1.9-1.9-1.9-2.0-1.7-1.7
Short access total infusions2.02.32.8-1.6-1.6-1.7-1.6-1.6-1.7-1.5-1.3-0.9
Short access day 1 locomotion2.12.22.7-1.6-1.6-1.4-1.6-1.7-1.6-1.5-1.5-0.6
Short access day 10 total locomotion1.51.72.0-1.2-1.2-1.3-1.4-1.4-1.4-1.4-1.2-1.0
Short access total locomotion2.72.83.7-1.8-1.8-1.6-1.9-1.9-1.9-1.7-1.6-0.7
One hour access (0.3 mA shock)4.14.86.6-1.8-1.8-2.2-2.3-2.3-2.6-2.2-2.4-2.2
Compulsive drug intake1.01.02.11.41.40.81.01.00.71.00.60.4
One hour access (shock baseline)3.74.35.6-1.8-1.8-2.0-2.2-2.2-2.4-2.1-2.2-1.7
Social response proportion0.10.20.40.70.70.30.0-0.0-0.30.1-0.60.3
Social responses0.40.60.90.90.90.70.70.70.60.60.80.5
Social time0.00.00.20.10.10.2-0.1-0.1-0.2-0.0-0.20.4
Soleus weight3.911.514.9-3.9-3.9-3.8-3.4-3.4-3.1-3.3-2.6-2.9
Bone: stiffness0.10.10.30.30.30.30.40.40.60.40.10.5
Tibialis anterior weight1.03.64.5-2.1-2.1-2.1-1.9-1.9-1.7-1.9-1.3-1.8
Time to tail flick, vehicle, before self-admin1.91.93.51.01.01.21.31.31.71.21.61.9
Time to tail flick, vehicle, after self-admin9.710.411.53.43.43.23.23.23.03.23.23.2
Time to tail flick, test, before self-admin1.31.31.9-1.1-1.1-1.1-1.4-1.4-1.0-1.2-1.2-0.1
Time to tail flick, test, after self-admin0.70.81.1-0.8-0.8-0.9-1.0-1.0-0.8-1.0-0.9-0.4
Delta time to tail flick, vehicle, before/after SA1.61.62.31.51.51.31.31.30.91.31.20.9
Delta time to tail flick, test, before/after SA1.91.72.7-1.1-1.1-1.3-1.2-1.2-1.4-1.3-1.4-1.6
Tibia length0.72.13.61.41.41.31.51.51.41.31.91.3
Ambulatory time before self-admin0.00.00.1-0.1-0.10.10.00.0-0.0-0.10.2-0.3
Ambulatory time after self-admin0.10.10.5-0.0-0.0-0.4-0.1-0.1-0.3-0.30.1-0.7
Bone: tissue strength0.30.30.50.50.50.40.60.50.50.50.70.6
Total heroin consumption3.94.66.4-1.8-1.8-2.0-2.0-2.0-2.5-2.0-2.3-2.5
Bone: trabecular number3.55.57.0-2.5-2.5-2.7-2.4-2.4-2.2-2.2-1.8-2.2
Bone: trabecular spacing0.50.60.90.80.81.00.80.80.70.60.60.9
Bone: trabecular thickness0.10.10.5-0.2-0.2-0.3-0.2-0.2-0.3-0.10.2-0.7
Bone: trabecular tissue density0.00.00.10.10.10.10.00.0-0.10.1-0.3-0.3
Water consumed over 24 hours0.20.30.4-0.6-0.6-0.6-0.5-0.5-0.4-0.3-0.3-0.5
Number of responses in last shaping day1.51.62.2-1.1-1.1-1.4-1.3-1.3-1.5-1.3-1.1-1.2