Hub : Genes

Asxl2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Asxl2 0.09 0.06 2.7e-13 0.11 0.11 0.11 0.11 1.2e-12 5.9e-13 1.1e-12 4.5e-13
2 Adipose gene expression Asxl2 0.16 0.12 4.6e-13 0.11 0.11 0.11 0.11 1.8e-12 5.9e-12 9.4e-12 6.4e-12
3 Brain mRNA stability Asxl2 0.09 0.07 6.8e-08 0.07 0.08 0.07 0.07 2.7e-07 5.5e-08 7.9e-07 2.7e-07
4 pVTA gene expression Asxl2 0.07 0.06 5.7e-03 0.04 0.03 0.03 0.03 7.8e-03 2.0e-02 2.7e-02 2.3e-02
5 OFC gene expression Asxl2 0.16 0.13 1.1e-03 0.12 0.12 0.12 0.11 1.2e-03 8.5e-04 1.2e-03 1.7e-03
6 PL gene expression Asxl2 0.07 0.08 4.9e-06 0.04 0.04 0.03 0.04 2.8e-05 1.1e-05 2.5e-04 4.8e-05
7 BLA gene expression Asxl2 0.14 0.1 1.2e-07 0.1 0.11 0.08 0.1 5.7e-06 2.0e-06 7.1e-05 6.2e-06
8 NAcc mRNA stability Asxl2 0.03 0.02 1.4e-03 0.02 0.02 0.02 0.01 4.6e-03 2.6e-03 5.3e-03 7.4e-03
9 LHb gene expression Asxl2 0.18 0.17 2.9e-03 0.07 0.08 0.08 0.08 9.6e-03 7.4e-03 6.2e-03 5.9e-03
10 Brain gene expression Asxl2 0.19 0.1 0.0e+00 0.25 0.26 0.25 0.26 4.3e-23 3.1e-24 8.1e-23 2.1e-24
11 Adipose mRNA stability Asxl2 0.27 0.18 0.0e+00 0.2 0.2 0.2 0.2 1.6e-21 4.5e-22 5.9e-22 1.0e-21
12 Liver gene expression Asxl2 0.11 0.08 5.0e-12 0.09 0.09 0.1 0.09 4.9e-10 3.2e-10 8.3e-11 7.0e-10

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density3.15.26.0-2.52.4-2.52.5-2.4-2.3-2.3-2.2-2.2-2.2-2.21.7
Area under the delay curve0.10.10.20.1-0.50.30.20.30.20.20.20.10.30.2-0.3
BMI with tail2.68.49.63.1-3.13.0-3.13.02.92.92.92.92.82.7-2.4
BMI without tail0.61.22.11.1-1.11.1-1.51.11.11.11.11.01.11.0-0.6
Body weight1.98.08.93.0-2.83.0-2.93.02.92.92.92.92.92.8-2.0
Weight adjusted by age0.40.41.01.0-0.80.8-0.80.70.60.60.60.50.60.5-0.0
Bone surface0.61.11.6-1.11.1-1.11.3-1.1-1.1-1.0-1.0-1.0-1.0-1.00.5
Bone volume1.72.93.9-1.81.8-1.82.0-1.8-1.8-1.7-1.7-1.6-1.7-1.61.1
Breakpoint value in progressive ratio session1.11.21.6-1.01.2-1.11.3-1.1-1.1-1.1-1.1-1.1-1.0-1.11.0
Number of licking bursts1.41.72.61.3-1.31.3-1.21.31.31.31.31.21.21.2-1.6
Context. condit. distance diff. score0.10.20.3-0.40.1-0.40.1-0.4-0.4-0.5-0.5-0.5-0.5-0.40.3
Locomotion velocity, session 10.60.60.90.9-0.50.7-0.70.70.70.80.80.90.80.8-0.8
Locomotion distance, session 10.50.61.5-0.71.2-0.91.0-0.8-0.7-0.7-0.7-0.6-0.6-0.70.7
Locomotion velocity, session 20.10.10.20.2-0.50.3-0.30.30.30.20.20.10.20.2-0.3
Locomotion distance, session 20.00.10.30.00.50.00.20.10.10.20.20.30.30.10.4
Locomotion velocity, session 30.00.00.0-0.2-0.2-0.0-0.1-0.1-0.1-0.1-0.1-0.2-0.2-0.1-0.1
Locomotion distance, session 30.00.00.20.1-0.10.1-0.20.10.20.20.20.20.20.2-0.4
Stereotopy head waving bouts, day 32.02.32.6-1.41.5-1.61.5-1.6-1.6-1.6-1.6-1.6-1.6-1.51.5
Stereotopy head waving duration, day 30.40.40.8-0.50.3-0.60.5-0.7-0.7-0.8-0.8-0.9-0.7-0.60.7
Locomotion velocity, session 70.00.00.20.1-0.10.1-0.30.20.10.10.20.10.10.1-0.5
Locomotion distance, session 70.91.21.71.1-1.11.1-1.31.11.01.11.11.01.00.9-1.2
Stereotopy head waving bouts, day 70.00.00.10.3-0.2-0.00.0-0.1-0.0-0.0-0.0-0.0-0.10.0-0.1
Stereotopy head waving duration, day 70.30.40.5-0.50.4-0.70.6-0.7-0.7-0.7-0.7-0.7-0.7-0.60.6
Locomotion velocity, session 80.50.60.7-0.70.8-0.80.6-0.8-0.8-0.8-0.8-0.8-0.8-0.70.5
Locomotion distance, session 80.30.40.6-0.60.8-0.70.5-0.7-0.7-0.7-0.7-0.6-0.6-0.70.5
Degree of sensitization distance0.91.01.31.1-1.11.0-1.11.01.01.00.90.90.90.9-0.7
Degree of sensitization stereotypy0.30.40.80.8-0.90.6-0.50.60.60.60.60.60.50.5-0.5
Conditioned locomotion3.44.04.5-2.01.7-2.02.1-2.0-2.1-2.1-2.1-2.0-2.1-2.11.7
Cocaine response after cond. corrected0.10.20.2-0.40.3-0.40.4-0.4-0.4-0.4-0.4-0.4-0.4-0.40.3
Cocaine response after cond. not corrected0.70.80.8-0.90.9-0.90.8-0.9-0.9-0.9-0.9-0.9-0.9-0.80.7
Cocaine response before conditioning2.12.63.0-1.61.7-1.61.7-1.6-1.6-1.6-1.6-1.6-1.6-1.61.5
Saline control response1.62.13.0-1.51.3-1.51.7-1.5-1.5-1.5-1.5-1.5-1.4-1.41.1
Bone: connectivity density1.93.03.7-1.91.6-1.91.9-1.8-1.8-1.8-1.7-1.7-1.7-1.71.2
Bone: cortical apparent density0.00.00.1-0.20.1-0.20.2-0.1-0.1-0.1-0.1-0.0-0.0-0.00.3
Bone: cortical area0.00.10.2-0.2-0.00.3-0.20.20.20.20.20.20.20.2-0.4
Bone: cortical porosity3.74.14.6-1.92.1-2.02.1-2.0-2.0-2.0-2.0-2.0-2.0-2.02.1
Bone: cortical porosity2.93.23.8-1.81.8-1.81.9-1.8-1.8-1.7-1.7-1.7-1.8-1.71.8
Bone: cortical thickness0.30.40.90.2-0.40.7-0.70.70.70.70.70.70.70.7-1.0
Bone: cortical thickness0.60.71.5-1.01.2-0.80.9-0.8-0.8-0.7-0.7-0.7-0.7-0.80.9
Bone: cortical tissue density0.00.00.1-0.10.1-0.10.2-0.1-0.0-0.0-0.00.10.00.10.2
Condit. Reinf. active minus inactive responses2.22.42.91.5-1.51.6-1.71.61.71.61.61.51.61.6-1.0
Condit. Reinf. active-inactive response ratio2.12.23.11.3-1.61.6-1.81.51.61.51.51.41.51.6-1.0
Condit. Reinf. active responses0.10.20.30.4-0.30.4-0.40.50.50.50.50.50.50.40.1
Condit. Reinf. inactive responses1.41.62.4-1.11.5-1.41.5-1.3-1.2-1.2-1.2-1.0-1.1-1.31.3
Incentive salience index mean0.20.30.40.5-0.50.6-0.60.60.60.60.50.50.60.6-0.1
Condit. Reinf. lever presses0.60.91.2-0.91.1-1.01.0-0.9-0.9-0.9-0.9-0.9-0.9-0.90.9
Condit. Reinf. active minus inactive responses1.31.62.1-1.11.3-1.31.5-1.3-1.3-1.3-1.3-1.2-1.2-1.31.4
Condit. Reinf. active-inactive response ratio0.70.70.9-0.70.8-0.91.0-0.9-0.9-0.9-0.9-0.8-0.8-0.90.7
Condit. Reinf. active responses0.81.11.7-0.81.0-1.11.3-1.0-1.0-1.0-1.0-0.9-0.9-1.11.2
Condit. Reinf. inactive responses0.20.20.5-0.40.5-0.50.7-0.4-0.4-0.4-0.4-0.4-0.4-0.50.7
Condit. Reinf. lever presses0.91.31.4-0.91.2-1.21.2-1.2-1.2-1.2-1.2-1.2-1.1-1.20.8
Condit. Reinf. lever reinforcers received0.71.01.6-0.81.1-1.01.3-0.9-1.0-0.9-0.9-0.9-0.9-1.01.2
Conditioned reinforcement - actives4.14.15.9-2.42.1-2.02.0-2.0-1.9-2.0-2.0-2.0-1.9-1.92.0
Conditioned reinforcement - inactives5.86.57.2-2.62.6-2.72.5-2.7-2.7-2.6-2.6-2.6-2.7-2.51.9
Conditioned locomotion4.45.26.8-2.42.6-2.42.5-2.3-2.3-2.2-2.2-2.2-2.2-2.12.1
Patch foraging indifference point 0 sec0.50.81.51.0-0.50.8-0.90.80.80.80.90.90.80.9-1.2
Patch foraging indifference point AUC0.00.00.0-0.1-0.10.0-0.2-0.0-0.1-0.0-0.0-0.0-0.1-0.1-0.0
Delay disc. indifference point, 0s delay1.01.11.71.1-1.31.0-0.51.01.01.11.11.01.01.0-1.3
Delay disc. indifference point, 16s delay0.00.00.10.2-0.10.20.00.30.20.30.30.20.30.2-0.0
Delay disc. indifference point, 2s delay0.20.20.40.4-0.60.4-0.30.40.40.40.40.30.40.4-0.6
Delay disc. indifference point, 24s delay3.02.93.8-1.72.0-1.81.9-1.7-1.7-1.6-1.6-1.6-1.6-1.61.4
Delay disc. indifference point, 4s delay0.30.30.50.4-0.70.6-0.10.60.50.50.50.40.60.4-0.6
Delay disc. indifference point, 8s delay0.00.00.3-0.2-0.20.00.5-0.0-0.0-0.0-0.0-0.1-0.0-0.1-0.1
Indifference point function ln k1.62.22.7-1.41.5-1.61.6-1.6-1.6-1.5-1.5-1.4-1.5-1.51.0
Indifference point function log k1.62.22.7-1.41.5-1.61.6-1.6-1.6-1.5-1.5-1.4-1.5-1.51.0
Patch foraging total patch changes 0 sec0.40.61.00.9-0.40.7-0.80.80.70.80.80.90.70.8-1.0
Patch foraging total patch changes 12 sec1.01.31.71.2-1.21.2-1.31.21.11.11.11.11.01.0-1.0
Patch foraging total patch changes 18 sec0.70.81.31.0-0.70.9-0.71.00.91.01.01.10.91.0-0.5
Patch foraging total patch changes 24 sec1.11.31.61.2-0.91.2-1.31.21.21.21.21.21.11.2-1.0
Patch foraging total patch changes 6 sec1.82.63.21.6-1.41.6-1.81.61.61.61.61.71.51.6-1.7
Patch foraging time to switch 0 sec0.40.61.30.9-1.10.9-0.70.80.80.80.70.60.80.8-0.6
Patch foraging water rate 0 sec1.62.54.3-1.52.1-1.81.7-1.6-1.6-1.5-1.5-1.3-1.5-1.51.3
Patch foraging water rate 12 sec0.00.10.10.1-0.10.2-0.20.20.30.30.30.30.30.3-0.2
Patch foraging water rate 18 sec1.41.83.4-1.51.8-1.51.4-1.4-1.3-1.3-1.3-1.2-1.2-1.21.1
Patch foraging water rate 24 sec0.00.10.20.0-0.10.2-0.20.20.20.30.30.40.20.2-0.2
Patch foraging water rate 6 sec0.30.41.2-0.51.1-0.70.8-0.6-0.6-0.5-0.5-0.4-0.5-0.50.9
Seeking ratio, delayed vs. immediate footshock0.00.00.10.1-0.30.2-0.30.10.10.10.10.00.00.1-0.1
Distance traveled before self-admin0.10.10.5-0.50.3-0.30.5-0.3-0.3-0.3-0.3-0.2-0.3-0.40.7
Distance traveled after self-admin0.20.20.30.4-0.20.3-0.60.40.40.40.40.60.40.4-0.3
Extensor digitorum longus weight2.28.611.7-3.43.2-3.03.0-3.0-2.9-2.9-2.9-2.7-2.8-2.82.6
Bone: elastic displacement1.61.82.7-1.71.5-1.51.3-1.4-1.3-1.3-1.3-1.3-1.3-1.21.0
Bone: elastic work0.40.61.1-1.00.9-0.80.6-0.8-0.7-0.7-0.7-0.7-0.7-0.60.4
Bone: endosteal estimation0.10.20.3-0.40.6-0.40.5-0.4-0.4-0.4-0.4-0.4-0.4-0.50.3
Bone: endosteal perimeter0.00.00.0-0.00.0-0.00.2-0.0-0.1-0.0-0.0-0.0-0.1-0.10.2
Epididymis fat weight17.340.246.36.2-6.86.6-6.86.56.46.36.36.26.26.2-5.6
Delta time in closed arm before/after self-admin0.40.40.70.7-0.80.6-0.80.60.50.50.50.40.40.5-0.8
Delta time in open arm before/after self-admin0.10.10.2-0.50.3-0.20.4-0.2-0.2-0.2-0.2-0.1-0.2-0.20.1
Diff in mean of infusions in LGA sessions0.00.00.10.0-0.2-0.1-0.2-0.2-0.2-0.2-0.2-0.2-0.2-0.20.2
Delay discount exponential model param0.00.00.10.10.2-0.1-0.4-0.0-0.0-0.0-0.00.1-0.10.00.1
Extinction: sum of active levers before priming0.40.40.6-0.60.3-0.60.4-0.7-0.7-0.7-0.7-0.8-0.7-0.80.7
Active lever presses in extinction session 61.81.82.1-1.41.2-1.41.4-1.4-1.4-1.4-1.4-1.4-1.3-1.31.0
Bone: final force0.00.10.3-0.1-0.30.2-0.20.20.20.10.10.10.10.2-0.5
Bone: final moment0.00.00.3-0.1-0.30.1-0.20.10.10.10.10.10.10.2-0.6
Food consumed during 24 hour testing period0.00.10.20.40.20.2-0.40.20.20.20.20.20.20.2-0.0
Glucose0.30.50.80.8-0.90.6-0.80.60.60.60.60.60.60.7-0.9
Heart weight4.97.08.22.4-2.92.7-2.72.72.72.62.62.62.72.6-2.3
Delay discount hyperbolic model param0.00.00.10.00.3-0.1-0.3-0.1-0.1-0.1-0.1-0.0-0.2-0.10.2
Intermittent access intake day 1-15 change2.22.23.4-1.51.8-1.51.5-1.5-1.4-1.4-1.4-1.3-1.3-1.41.6
Intermittent access intake escalation1.31.32.4-1.21.6-1.21.2-1.1-1.1-1.0-1.0-1.0-1.0-1.01.4
Intermittent access intake escalation 20.00.00.1-0.10.40.0-0.10.10.20.20.20.20.30.20.2
Intermitt. access day 1 inactive lever presses0.10.10.2-0.50.3-0.40.3-0.3-0.4-0.3-0.3-0.2-0.3-0.40.3
Intermitt. access day 15 inactive lever presses1.41.62.1-1.21.0-1.21.1-1.3-1.3-1.3-1.3-1.5-1.3-1.31.2
Intermitt. access escalation Index3.53.14.52.1-2.01.8-1.91.81.71.71.71.61.61.6-1.4
Intermittent access day 1 total infusions2.93.44.6-2.01.2-1.71.5-1.9-1.9-2.0-2.0-2.1-2.0-2.01.7
Intermittent access day 15 total infusions4.34.86.4-2.42.0-2.12.0-2.1-2.2-2.2-2.2-2.3-2.2-2.22.5
Intermittent access terminal intake (last 3 days)3.53.84.3-2.11.8-1.91.7-1.9-2.0-2.0-2.0-2.1-2.0-2.02.1
Intermittent access total infusions4.75.26.1-2.51.9-2.22.0-2.3-2.3-2.4-2.4-2.5-2.4-2.42.3
Intermittent access day 1 locomotion2.42.52.9-1.61.4-1.61.5-1.6-1.6-1.6-1.6-1.6-1.7-1.71.5
Intermittent access day 15 total locomotion0.40.40.8-0.90.6-0.60.5-0.6-0.6-0.7-0.7-0.7-0.7-0.60.6
Intermittent access total locomotion1.11.21.6-1.31.1-1.11.0-1.1-1.1-1.1-1.1-1.1-1.1-1.11.2
Intermittent access standard deviation0.80.91.7-1.30.9-0.80.5-0.9-0.8-0.9-0.9-0.9-0.9-0.91.3
Left kidney weight0.51.32.3-1.50.8-1.10.9-1.2-1.2-1.2-1.2-1.2-1.3-1.20.6
Right kidney weight0.10.30.70.2-0.80.5-0.90.50.50.50.40.50.50.5-0.8
Cocaine induced anxiety0.10.10.3-0.20.3-0.30.5-0.2-0.2-0.2-0.2-0.2-0.1-0.1-0.2
Post-drug Anxiety1.31.42.51.0-0.91.1-0.91.21.21.21.21.21.31.3-1.6
Baseline Anxiety1.31.41.81.1-1.11.2-1.31.21.21.21.21.21.21.2-1.0
Tail length0.20.61.4-0.81.2-0.80.6-0.7-0.6-0.7-0.6-0.7-0.6-0.60.9
Length with tail0.00.10.30.30.30.3-0.10.40.40.40.40.50.50.50.2
Length without tail0.00.10.20.30.10.20.30.20.10.30.30.50.20.3-0.1
Times rat made contact with spout0.80.91.8-0.91.3-1.00.9-0.9-0.9-0.8-0.8-0.8-0.8-0.81.2
Lifetime Intake5.36.07.1-2.72.0-2.42.2-2.5-2.5-2.5-2.5-2.6-2.5-2.52.4
Liver weight, left1.11.72.51.3-1.21.3-1.61.31.31.31.31.41.31.3-1.2
Liver weight, right5.48.910.03.2-2.93.0-3.13.02.93.03.03.12.92.9-2.8
Locomotor activity0.61.01.31.1-1.11.1-1.01.01.01.01.00.90.91.0-1.1
Locomotor testing distance0.50.81.21.0-1.11.0-0.90.90.90.80.80.80.80.9-0.9
Locomotor testing rearing0.30.50.7-0.50.5-0.70.9-0.7-0.7-0.8-0.8-0.8-0.9-0.80.6
Locomotion in novel chamber0.40.50.60.7-0.70.7-0.70.70.70.70.70.70.80.8-0.5
Locomotion in novel chamber post-restriction2.32.73.71.9-1.41.7-1.21.71.71.81.81.91.81.7-1.2
Fecal boli incidents, locomotor time 13.23.64.0-2.02.0-2.02.0-1.9-1.9-1.9-1.9-1.8-1.9-1.91.5
Change in fecal boli incidents, locomotor task3.53.33.91.9-1.91.9-2.01.91.81.81.81.81.81.7-1.4
Time >=10cm from walls, locomotor time 10.60.61.0-0.70.9-0.70.8-0.7-0.7-0.7-0.7-0.7-0.7-0.81.0
Bouts of movement, locomotor time 10.00.00.1-0.10.3-0.10.2-0.1-0.1-0.1-0.0-0.0-0.0-0.2-0.2
Total resting periods, locomotor time 10.00.00.2-0.10.4-0.20.4-0.2-0.2-0.1-0.1-0.1-0.1-0.2-0.2
Rest time, locomotor task time 10.00.00.4-0.00.1-0.10.2-0.1-0.1-0.1-0.1-0.1-0.1-0.1-0.6
Distance moved, locomotor task time 10.20.20.40.6-0.40.4-0.50.40.40.40.40.40.40.50.0
Vertical activity count, locomotor time 10.20.20.30.5-0.20.4-0.40.40.40.50.40.50.50.50.2
Time >=10cm from walls, locomotor time 21.61.72.0-1.31.1-1.31.1-1.3-1.4-1.3-1.3-1.3-1.4-1.31.4
Bouts of movement, locomotor time 20.50.50.60.8-0.50.7-0.40.70.70.80.80.80.80.6-0.7
Total resting periods, locomotor time 20.60.60.80.9-0.60.8-0.50.80.80.80.80.90.80.7-0.9
Rest time, locomotor task time 20.10.10.80.3-0.00.00.30.10.10.10.10.10.10.1-0.9
Distance moved, locomotor task time 20.00.00.1-0.10.1-0.2-0.0-0.2-0.2-0.2-0.2-0.2-0.2-0.10.3
Vertical activity count, locomotor time 20.30.30.4-0.40.1-0.50.3-0.6-0.6-0.6-0.6-0.6-0.6-0.50.5
Light reinforcement 10.40.81.0-0.60.7-0.81.0-0.9-0.9-0.9-0.9-1.0-0.9-0.90.8
Light reinforcement 21.21.72.1-1.01.2-1.31.5-1.3-1.4-1.3-1.3-1.2-1.3-1.41.3
Bone: marrow area0.10.20.3-0.40.6-0.40.5-0.4-0.5-0.4-0.4-0.4-0.5-0.50.4
Bone: maximum diameter0.00.00.1-0.30.2-0.10.2-0.0-0.1-0.0-0.0-0.0-0.1-0.1-0.4
Bone: maximum force0.00.00.1-0.1-0.20.2-0.30.20.10.10.10.10.10.1-0.3
Bone: maximum moment0.00.00.1-0.1-0.10.1-0.20.10.10.10.10.10.10.1-0.3
Mean time between licks in bursts1.82.63.21.8-1.71.6-1.71.61.61.61.61.51.51.5-1.6
Mean num. licks in bursts1.82.23.3-1.51.7-1.51.3-1.5-1.4-1.4-1.4-1.3-1.4-1.31.8
Cd content in liver0.30.30.50.40.20.5-0.70.60.60.60.60.50.70.60.1
Co content in liver4.65.46.0-2.22.1-2.42.4-2.3-2.3-2.4-2.4-2.5-2.3-2.42.2
Cu content in liver0.10.10.6-0.2-0.0-0.20.1-0.2-0.2-0.3-0.3-0.3-0.3-0.40.8
Fe content in liver0.20.20.6-0.40.7-0.50.5-0.5-0.5-0.4-0.4-0.4-0.4-0.50.8
K content in liver2.12.13.01.7-1.41.5-1.61.41.41.41.41.31.31.3-1.4
Mg content in liver1.71.82.21.5-1.41.4-1.41.31.31.31.31.21.21.3-1.5
Mn content in liver0.20.20.50.5-0.50.5-0.40.50.40.50.50.50.40.5-0.7
Na content in liver1.92.02.5-1.21.4-1.61.3-1.6-1.6-1.5-1.5-1.5-1.5-1.40.3
Rb content in liver0.40.51.01.0-0.60.8-0.90.70.70.70.70.60.70.7-0.2
Se content in liver0.70.91.21.1-1.00.9-1.00.90.91.00.91.00.90.9-0.8
Sr content in liver0.10.10.20.4-0.30.2-0.20.20.20.20.20.20.20.2-0.3
Zn content in liver1.41.62.71.6-1.51.3-1.21.31.21.31.21.11.11.1-0.9
Bone: minimum diameter0.50.91.30.7-1.11.1-1.01.01.01.00.90.90.90.9-0.8
Time in familiar zone, hab. session 10.90.81.20.9-1.11.0-1.10.90.90.90.90.90.90.9-0.7
Time in novel zone, hab. session 10.20.20.30.6-0.50.5-0.30.50.50.50.50.50.50.5-0.4
Total zone transitions, hab. session 10.20.30.8-0.60.9-0.60.5-0.5-0.4-0.4-0.4-0.4-0.3-0.40.3
Total locomotion distance, hab. session 10.81.22.1-1.21.5-1.21.1-1.1-1.0-1.0-1.0-0.9-0.9-1.01.0
Locomotion velocity, hab. session 11.52.13.3-1.61.8-1.61.5-1.5-1.4-1.4-1.4-1.3-1.3-1.41.2
Time in familiar zone, hab. session 20.40.40.70.7-0.70.6-0.80.60.60.60.60.50.50.6-0.7
Time in novel zone, hab. session 20.00.00.10.1-0.20.10.20.10.10.10.10.10.10.10.3
Total zone transitions, hab. session 20.10.20.30.30.30.2-0.20.30.40.40.50.60.50.5-0.5
Total locomotion distance, hab. session 20.10.20.30.30.30.2-0.10.40.40.50.50.50.60.5-0.3
Locomotion velocity, hab. session 20.10.10.20.10.40.10.00.20.30.30.30.40.40.4-0.2
Novel to familiar place preference ratio0.30.30.50.70.20.5-0.20.50.50.60.60.70.60.6-0.1
Novelty place preference0.50.50.80.9-0.10.7-0.30.80.70.80.80.90.80.8-0.2
Time in novel zone, NPP test0.40.50.70.8-0.00.7-0.30.70.70.80.80.80.80.7-0.0
Total zone transitions, NPP test0.81.21.5-1.01.2-1.21.1-1.1-1.1-1.1-1.1-1.0-1.0-1.11.1
Total locomotion distance, NPP test1.42.02.9-1.31.7-1.51.5-1.4-1.4-1.3-1.3-1.3-1.3-1.31.4
Locomotion velocity, NPP test1.82.63.8-1.51.9-1.81.8-1.7-1.6-1.6-1.5-1.5-1.5-1.51.4
Intraocular pressure3.85.46.22.4-2.22.3-1.92.42.32.42.42.52.42.3-2.2
Delta distance traveled before/after self-admin1.92.13.51.6-1.31.3-1.91.31.31.31.31.31.31.3-1.8
Delta ambulatory time before/after self-admin0.40.51.40.8-0.50.5-0.90.50.50.60.60.60.60.6-1.2
Parametrial fat weight10.720.927.44.5-4.94.7-5.24.64.64.54.44.44.34.5-4.1
Pavlov. Cond. lever latency0.40.60.70.7-0.70.8-0.80.80.80.80.80.70.80.8-0.5
Pavlov. Cond. magazine entry latency0.00.00.10.2-0.10.10.00.20.20.20.20.20.20.2-0.2
Pavlov. Cond. change in total contacts0.00.00.1-0.1-0.0-0.20.1-0.2-0.2-0.2-0.2-0.2-0.2-0.3-0.1
Pavlov. Cond. index score0.00.10.1-0.10.1-0.30.4-0.3-0.3-0.2-0.2-0.2-0.2-0.3-0.1
Pavlov. Cond. latency score0.00.00.1-0.10.1-0.20.3-0.1-0.2-0.1-0.1-0.1-0.1-0.2-0.2
Pavlov. Cond. lever contacts0.40.40.5-0.60.5-0.70.7-0.7-0.7-0.7-0.7-0.7-0.7-0.70.0
Pavlov. Cond. magazine entry number0.00.00.10.0-0.40.2-0.30.10.10.00.0-0.00.00.10.1
Pavlov. Cond. intertrial magazine entries1.92.43.6-1.61.2-1.51.4-1.5-1.5-1.5-1.6-1.5-1.6-1.51.9
Pavlov. Cond. lever-magazine prob. diff.0.30.40.6-0.60.5-0.70.8-0.7-0.7-0.7-0.7-0.7-0.7-0.70.3
Pavlov. Cond. response bias0.91.11.3-1.01.0-1.11.1-1.1-1.1-1.1-1.1-1.0-1.1-1.10.6
Pavlov. Cond. lever latency0.70.91.10.8-0.81.0-1.01.01.01.01.01.01.01.0-0.4
Pavlov. Cond. magazine entry latency0.00.00.30.4-0.20.10.10.10.10.10.10.10.10.1-0.6
Pavlov. Cond. change in total contacts0.00.00.1-0.10.1-0.10.2-0.1-0.2-0.1-0.1-0.1-0.1-0.2-0.3
Pavlov. Cond. index score0.20.30.5-0.40.5-0.60.7-0.6-0.6-0.6-0.6-0.6-0.6-0.6-0.0
Pavlov. Cond. latency score0.30.30.5-0.40.6-0.60.7-0.6-0.6-0.6-0.6-0.6-0.6-0.6-0.0
Pavlov. Cond. lever contacts0.10.20.3-0.30.3-0.40.4-0.4-0.5-0.5-0.5-0.5-0.5-0.50.0
Pavlov. Cond. magazine entry number0.10.20.4-0.50.5-0.40.2-0.4-0.3-0.4-0.4-0.4-0.3-0.30.6
Pavlov. Cond. intertrial magazine entries2.12.83.51.5-1.21.7-1.81.71.81.81.81.81.81.9-0.9
Pavlov. Cond. lever-magazine prob. diff.0.10.10.1-0.10.3-0.30.4-0.3-0.3-0.3-0.3-0.3-0.3-0.3-0.3
Pavlov. Cond. response bias0.20.30.5-0.50.4-0.60.6-0.6-0.6-0.6-0.6-0.7-0.6-0.70.0
Time in closed arm before self-admin0.10.10.30.20.60.00.50.10.10.20.30.60.20.20.2
Time in closed arm after self-admin0.50.50.80.7-0.30.7-0.50.70.70.80.80.90.80.8-0.5
Time in open arm before self-admin0.10.10.40.3-0.60.3-0.60.20.20.20.2-0.10.20.2-0.1
Time in open arm after self-admin0.10.20.4-0.60.3-0.40.1-0.4-0.3-0.4-0.4-0.5-0.4-0.40.4
Bone: periosteal estimation0.10.20.4-0.70.6-0.40.4-0.4-0.4-0.4-0.4-0.4-0.4-0.50.2
Bone: periosteal perimeter0.00.00.1-0.0-0.10.2-0.00.10.10.10.10.00.10.1-0.3
Bone: post-yield work1.72.42.8-1.71.5-1.51.3-1.6-1.5-1.6-1.6-1.6-1.6-1.61.5
Progressive ratio test 1 active lever presses2.72.83.5-1.91.5-1.61.4-1.7-1.7-1.7-1.7-1.9-1.7-1.71.5
Progressive ratio test 1 breakpoint1.92.02.7-1.71.2-1.41.1-1.5-1.4-1.5-1.5-1.6-1.5-1.51.1
Progressive ratio test 1 inactive lever presses4.75.26.2-2.41.9-2.21.9-2.3-2.3-2.4-2.4-2.5-2.4-2.42.1
Progressive ratio test 2 active lever presses2.32.52.9-1.71.6-1.61.4-1.6-1.6-1.6-1.6-1.7-1.5-1.61.4
Progressive ratio test 2 breakpoint2.42.73.1-1.71.6-1.61.5-1.7-1.7-1.7-1.7-1.8-1.6-1.61.5
Progressive ratio test 2 inactive lever presses3.03.54.2-2.01.8-1.91.7-1.9-1.9-1.9-1.9-2.1-1.9-1.91.6
Incentive Sensitization - Responses1.71.72.2-1.11.3-1.31.1-1.3-1.4-1.3-1.3-1.4-1.3-1.31.5
Incentive Sensitization - Breakpoint1.11.11.6-0.91.1-1.00.9-1.0-1.1-1.0-1.1-1.1-1.0-1.11.3
Sum of active levers in priming session hrs 5-60.10.10.30.5-0.00.2-0.10.20.20.30.30.30.20.2-0.3
Progressive ratio0.30.31.1-0.30.3-0.50.7-0.5-0.6-0.5-0.5-0.5-0.5-0.51.0
Food seeking constrained by brief footshock15.318.920.0-4.34.2-4.43.9-4.4-4.5-4.4-4.4-4.5-4.4-4.44.3
Seeking ratio, punishment vs. effort1.41.72.6-1.61.4-1.41.0-1.3-1.3-1.3-1.3-1.3-1.3-1.30.7
Retroperitoneal fat weight32.2105.7122.210.2-11.110.7-10.610.510.410.210.210.110.110.1-9.1
Reaction time number correct0.30.40.7-0.80.9-0.60.9-0.5-0.5-0.5-0.5-0.4-0.4-0.50.7
Reaction time mean minus median0.10.10.40.2-0.60.3-0.30.20.20.20.10.00.20.20.0
Reaction time mean minus median AUC0.20.20.40.4-0.70.5-0.60.40.50.40.40.30.40.5-0.2
Reaction time num false alarms1.52.02.91.7-1.21.5-1.41.51.41.51.51.41.41.3-0.8
Reaction time num false alarms AUC1.52.03.11.8-1.21.5-1.41.51.51.51.51.41.41.4-0.9
Reaction time trials correct on left0.30.40.7-0.80.9-0.60.9-0.5-0.5-0.5-0.5-0.4-0.4-0.50.7
Reaction time trials on left0.20.40.7-0.80.8-0.60.8-0.5-0.5-0.4-0.5-0.3-0.4-0.50.7
Reaction time mean0.10.10.50.3-0.70.4-0.50.30.30.30.30.20.30.3-0.2
Reaction time mean AUC0.00.00.20.2-0.50.2-0.30.20.20.10.10.00.10.10.0
Median of all reaction times0.00.00.10.1-0.40.2-0.30.10.10.10.10.00.10.1-0.1
Reaction time omissions0.20.30.50.4-0.50.6-0.40.60.70.60.60.50.70.6-0.3
Reaction time false alarm rate2.13.04.42.1-1.61.8-1.81.81.71.71.71.61.71.6-1.3
Reaction time premature initiation rate0.10.10.30.6-0.00.3-0.10.40.40.40.40.40.40.4-0.3
Reaction time premature initiations0.00.00.20.10.4-0.10.40.00.00.10.10.20.10.10.1
Std. dev. reaction times0.30.40.80.6-0.90.7-0.70.70.70.60.60.50.60.7-0.2
Reaction time trials completed0.20.40.7-0.80.8-0.60.8-0.5-0.5-0.4-0.5-0.3-0.4-0.50.7
Reaction time trials AUC0.30.40.8-0.80.8-0.60.9-0.6-0.5-0.5-0.5-0.4-0.4-0.50.7
Run reversals in cocaine runway, females0.30.30.5-0.60.7-0.60.4-0.6-0.6-0.6-0.6-0.6-0.6-0.60.3
Run reversals in cocaine runway, males1.11.11.7-1.31.2-1.10.8-1.1-1.0-1.1-1.0-1.0-0.9-1.01.0
Latency to leave start box in cocaine runway0.20.20.4-0.7-0.1-0.3-0.1-0.4-0.4-0.5-0.5-0.6-0.5-0.5-0.0
Latency to leave start box in cocaine runway, F0.00.10.3-0.1-0.30.0-0.5-0.1-0.1-0.2-0.2-0.3-0.2-0.2-0.1
Latency to leave start box in cocaine runway, M1.51.42.4-1.50.9-1.21.0-1.2-1.2-1.3-1.3-1.2-1.2-1.30.9
Std. dev. time between licks in bursts0.80.91.51.2-0.90.9-0.71.00.91.01.01.01.00.9-1.0
Total sessions with >9 infusions6.97.67.9-2.82.6-2.82.8-2.8-2.7-2.8-2.8-2.7-2.8-2.72.8
Short access day 1 total inactive lever presses2.32.64.1-2.01.2-1.61.4-1.6-1.6-1.7-1.7-1.7-1.7-1.61.3
Short access day 10 total inactive lever presses0.20.20.60.4-0.70.4-0.40.30.30.30.30.20.30.3-0.8
Short access day 1 total infusions4.34.55.6-2.41.7-2.11.9-2.2-2.1-2.2-2.2-2.3-2.3-2.22.0
Short access day 10 total infusions5.96.67.8-2.82.0-2.52.3-2.6-2.6-2.7-2.7-2.7-2.7-2.62.6
Short access total infusions4.45.06.0-2.41.8-2.21.8-2.3-2.2-2.4-2.4-2.4-2.4-2.32.0
Short access day 1 locomotion5.45.86.2-2.52.3-2.42.5-2.4-2.4-2.4-2.4-2.4-2.5-2.42.4
Short access day 10 total locomotion1.61.82.7-1.11.4-1.41.3-1.3-1.4-1.3-1.3-1.2-1.4-1.31.6
Short access total locomotion2.52.63.0-1.61.6-1.71.6-1.7-1.6-1.6-1.6-1.5-1.7-1.61.6
One hour access (0.3 mA shock)2.52.94.9-2.21.9-1.81.7-1.7-1.6-1.6-1.6-1.6-1.5-1.51.5
Compulsive drug intake4.14.15.01.9-2.12.0-2.02.02.12.02.02.11.92.0-2.2
One hour access (shock baseline)6.98.09.4-3.13.0-2.82.8-2.8-2.8-2.8-2.8-2.8-2.7-2.72.9
Social response proportion0.10.10.4-0.4-0.0-0.20.6-0.3-0.2-0.3-0.3-0.4-0.3-0.20.2
Social responses0.20.20.70.3-0.50.4-0.20.40.40.40.40.30.40.5-0.8
Social time0.10.10.3-0.50.0-0.20.5-0.3-0.2-0.3-0.3-0.4-0.3-0.20.3
Soleus weight2.77.911.4-3.43.1-2.92.9-2.8-2.8-2.8-2.7-2.6-2.7-2.72.3
Bone: stiffness0.10.20.50.3-0.70.5-0.50.50.40.40.40.40.40.3-0.4
Tibialis anterior weight0.93.14.8-2.02.2-1.81.9-1.8-1.7-1.7-1.7-1.5-1.6-1.61.5
Time to tail flick, vehicle, before self-admin0.40.40.91.0-0.50.6-0.30.60.50.60.60.60.60.6-0.4
Time to tail flick, vehicle, after self-admin6.57.07.72.4-2.62.7-2.62.72.82.72.72.82.82.7-2.2
Time to tail flick, test, before self-admin1.71.72.8-1.01.6-1.31.6-1.2-1.2-1.1-1.1-1.1-1.2-1.21.7
Time to tail flick, test, after self-admin1.11.21.5-1.01.1-1.11.2-1.1-1.1-1.1-1.0-1.1-1.0-1.11.1
Delta time to tail flick, vehicle, before/after SA2.52.53.31.3-1.61.6-1.81.61.71.61.61.61.61.6-1.1
Delta time to tail flick, test, before/after SA1.41.31.6-1.20.7-1.11.0-1.2-1.2-1.2-1.2-1.3-1.3-1.20.5
Tibia length0.71.92.21.1-1.11.4-1.51.41.51.41.41.31.51.5-1.3
Ambulatory time before self-admin0.10.10.4-0.30.3-0.20.5-0.2-0.2-0.3-0.3-0.1-0.3-0.30.6
Ambulatory time after self-admin0.10.10.20.3-0.00.1-0.40.20.20.20.20.40.30.2-0.1
Bone: tissue strength0.70.71.30.7-1.10.8-0.80.80.80.80.80.80.80.9-1.1
Total heroin consumption1.41.72.2-1.21.4-1.41.5-1.4-1.4-1.3-1.3-1.3-1.2-1.30.6
Bone: trabecular number3.45.26.3-2.52.3-2.42.3-2.4-2.4-2.3-2.3-2.3-2.3-2.21.9
Bone: trabecular spacing0.91.21.61.2-1.01.1-1.31.11.11.01.01.01.01.0-1.1
Bone: trabecular thickness0.60.71.3-0.80.7-0.80.9-0.7-0.8-0.7-0.7-0.7-0.8-0.81.2
Bone: trabecular tissue density0.10.21.3-0.30.3-0.30.1-0.3-0.3-0.3-0.4-0.4-0.3-0.41.1
Water consumed over 24 hours0.10.10.3-0.20.6-0.20.4-0.2-0.2-0.1-0.1-0.1-0.1-0.2-0.1
Number of responses in last shaping day2.62.73.2-1.61.2-1.61.8-1.6-1.7-1.7-1.7-1.7-1.7-1.71.6