Hub : Genes

Eno4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Eno4	0.06	0.04	7.7e-05	0.01	0.03	0.02	0.01	5.5e-02	7.6e-04	9.3e-04	9.2e-03
2	NAcc	gene expression	Eno4	0.04	0.04	3.3e-03	0.01	0.01	0.01	0	5.1e-02	1.6e-02	2.9e-02	1.3e-01
3	NAcc	alternative polyA	NM_001134505.1	0.04	0.03	2.2e-04	0.03	0.03	0.03	0.03	1.6e-04	2.5e-04	2.7e-04	3.5e-04
4	NAcc	alternative polyA	XM_006231669.4	0.05	0.03	9.5e-05	0.03	0.03	0.03	0.03	6.9e-05	9.0e-05	9.2e-05	1.2e-04
5	NAcc	alternative polyA	NM_001134505.1	0.04	0.03	4.3e-04	0.03	0.03	0.03	0.03	6.3e-04	4.6e-04	4.7e-04	4.6e-04
6	RMTg	alternative TSS	XM_039103296.1	0.13	0.1	8.8e-03	0.03	0.04	0.01	0.02	5.4e-02	2.6e-02	1.3e-01	8.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	0.7	1.2	4.6	-1.2	-0.1	0.6	-0.6	-0.6	-2.1
Area under the delay curve	3.4	3.6	4.8	-1.9	-1.9	-2.2	2.2	2.0	0.7
BMI with tail	2.7	8.8	26.9	-5.2	-2.5	-2.6	2.6	2.2	-1.2
BMI without tail	2.5	5.1	13.8	-3.7	-2.2	-1.9	1.9	1.8	-1.0
Body weight	3.2	13.5	38.9	-6.2	-3.3	-3.2	3.2	2.9	-1.5
Weight adjusted by age	0.7	0.8	1.7	-1.3	-0.6	-1.1	1.1	0.7	0.1
Bone surface	0.6	1.0	3.2	-0.7	0.4	0.8	-0.8	-0.9	-1.8
Bone volume	0.5	0.8	2.6	-1.6	-0.5	-0.1	0.1	0.0	-1.5
Breakpoint value in progressive ratio session	2.1	2.3	4.0	-2.0	-1.9	-1.3	1.3	1.3	-1.1
Number of licking bursts	1.7	1.9	3.1	0.5	0.9	1.7	-1.7	-1.4	-1.8
Context. condit. distance diff. score	0.9	1.0	1.5	1.1	1.2	1.1	-1.1	-1.1	-0.0
Locomotion velocity, session 1	0.1	0.1	0.1	0.4	0.2	0.2	-0.2	-0.2	0.0
Locomotion distance, session 1	0.8	1.1	2.2	1.5	1.3	0.8	-0.8	-0.9	0.9
Locomotion velocity, session 2	1.9	2.2	4.6	2.1	1.7	1.2	-1.2	-1.3	0.9
Locomotion distance, session 2	0.8	1.1	2.2	1.2	1.5	0.9	-0.9	-1.0	0.8
Locomotion velocity, session 3	0.6	0.7	1.5	1.2	1.0	0.7	-0.7	-0.7	0.6
Locomotion distance, session 3	1.0	1.1	2.0	1.4	1.3	0.7	-0.7	-0.8	1.1
Stereotopy head waving bouts, day 3	0.1	0.2	0.3	0.1	-0.3	-0.4	0.4	0.5	0.6
Stereotopy head waving duration, day 3	0.0	0.0	0.0	0.2	-0.2	-0.0	0.0	0.1	-0.1
Locomotion velocity, session 7	0.7	0.8	1.3	0.7	1.1	1.0	-1.0	-1.1	-0.2
Locomotion distance, session 7	0.6	0.8	1.7	0.9	1.3	0.8	-0.8	-1.0	0.5
Stereotopy head waving bouts, day 7	0.1	0.1	0.4	-0.2	-0.2	0.1	-0.1	-0.1	-0.6
Stereotopy head waving duration, day 7	1.0	1.2	2.0	-1.2	-1.4	-1.1	1.1	1.2	-0.3
Locomotion velocity, session 8	2.9	3.5	4.4	1.9	1.9	2.1	-2.1	-2.1	-0.8
Locomotion distance, session 8	5.4	7.9	10.8	3.0	3.3	3.0	-3.0	-3.1	-0.3
Degree of sensitization distance	0.2	0.2	0.7	-0.7	-0.3	0.0	-0.0	-0.0	-0.9
Degree of sensitization stereotypy	0.3	0.3	0.8	-0.9	-0.5	-0.3	0.3	0.3	-0.7
Conditioned locomotion	0.3	0.4	0.5	-0.4	-0.6	-0.7	0.7	0.7	0.4
Cocaine response after cond. corrected	1.9	2.2	5.4	2.3	1.5	0.6	-0.6	-0.7	2.1
Cocaine response after cond. not corrected	1.7	1.9	5.2	2.3	1.4	0.7	-0.7	-0.8	1.6
Cocaine response before conditioning	0.4	0.5	2.1	-0.5	-0.5	0.3	-0.3	-0.1	-1.5
Saline control response	0.2	0.3	0.5	-0.2	-0.3	-0.7	0.7	0.5	0.7
Bone: connectivity density	0.6	1.0	3.1	-0.4	0.4	0.9	-0.9	-0.9	-1.8
Bone: cortical apparent density	1.4	1.8	4.6	2.1	1.3	0.5	-0.5	-0.5	2.0
Bone: cortical area	0.7	1.0	3.1	-1.4	0.2	0.5	-0.5	-0.7	-1.8
Bone: cortical porosity	0.3	0.4	1.0	-0.9	-0.6	-0.2	0.2	0.2	-1.0
Bone: cortical porosity	0.8	0.8	1.9	-1.4	-1.0	-0.4	0.4	0.5	-1.2
Bone: cortical thickness	1.0	1.6	2.6	0.0	1.5	1.3	-1.3	-1.6	-1.0
Bone: cortical thickness	0.1	0.1	0.2	-0.4	0.5	0.0	-0.0	-0.3	0.2
Bone: cortical tissue density	1.4	1.8	4.7	2.2	1.2	0.4	-0.4	-0.5	2.0
Condit. Reinf. active minus inactive responses	1.5	1.7	2.1	1.2	1.3	1.5	-1.5	-1.5	-0.6
Condit. Reinf. active-inactive response ratio	0.6	0.7	1.0	0.8	0.7	1.0	-1.0	-0.9	-0.6
Condit. Reinf. active responses	1.7	2.1	3.0	0.6	1.5	1.6	-1.6	-1.7	-1.2
Condit. Reinf. inactive responses	1.3	1.5	2.2	0.1	1.2	1.4	-1.4	-1.5	-1.3
Incentive salience index mean	1.6	1.9	2.7	1.4	1.6	1.5	-1.5	-1.6	-0.2
Condit. Reinf. lever presses	0.4	0.6	1.0	0.8	1.0	0.7	-0.7	-0.8	0.2
Condit. Reinf. active minus inactive responses	0.7	0.9	2.3	-1.4	-1.0	-0.4	0.4	0.4	-1.5
Condit. Reinf. active-inactive response ratio	0.5	0.5	1.2	-1.1	-0.7	-0.4	0.4	0.3	-0.9
Condit. Reinf. active responses	1.1	1.5	3.5	-1.9	-1.2	-0.5	0.5	0.5	-1.8
Condit. Reinf. inactive responses	0.5	0.6	1.5	-1.2	-0.9	-0.4	0.4	0.4	-1.0
Condit. Reinf. lever presses	0.3	0.5	1.3	-1.1	-0.6	-0.2	0.2	0.2	-1.1
Condit. Reinf. lever reinforcers received	0.7	1.0	3.4	-1.3	-0.8	-0.1	0.1	0.1	-1.8
Conditioned reinforcement - actives	1.7	1.7	4.6	2.1	1.3	1.1	-1.1	-0.9	0.8
Conditioned reinforcement - inactives	0.1	0.1	0.4	-0.2	-0.4	0.1	-0.1	0.1	-0.6
Conditioned locomotion	1.9	2.2	5.3	2.3	1.6	1.3	-1.3	-1.3	0.7
Patch foraging indifference point 0 sec	0.3	0.5	1.7	-1.3	-0.2	-0.3	0.3	-0.1	-1.1
Patch foraging indifference point AUC	0.5	0.5	1.6	-1.2	-0.7	-0.4	0.4	0.5	-0.7
Delay disc. indifference point, 0s delay	0.2	0.2	0.6	-0.2	0.0	-0.4	0.4	0.3	0.8
Delay disc. indifference point, 16s delay	2.2	2.2	3.0	-1.4	-1.5	-1.7	1.7	1.6	0.5
Delay disc. indifference point, 2s delay	2.2	2.4	3.4	-0.8	-1.2	-1.8	1.8	1.7	1.7
Delay disc. indifference point, 24s delay	1.2	1.2	2.0	-1.4	-1.2	-1.1	1.1	1.0	-0.3
Delay disc. indifference point, 4s delay	2.1	2.3	3.1	-1.3	-1.5	-1.8	1.8	1.6	0.7
Delay disc. indifference point, 8s delay	2.6	2.6	3.5	-1.6	-1.7	-1.9	1.9	1.8	0.6
Indifference point function ln k	0.3	0.4	0.8	0.9	0.9	0.4	-0.4	-0.7	0.4
Indifference point function log k	0.3	0.4	0.8	0.9	0.9	0.4	-0.4	-0.7	0.4
Patch foraging total patch changes 0 sec	0.4	0.7	2.2	-1.5	-0.2	-0.3	0.3	-0.1	-1.3
Patch foraging total patch changes 12 sec	0.6	0.8	2.5	-1.6	-0.5	-0.2	0.2	0.0	-1.5
Patch foraging total patch changes 18 sec	1.3	1.6	4.4	-2.1	-1.3	-0.8	0.8	0.7	-1.4
Patch foraging total patch changes 24 sec	1.0	1.2	3.0	-1.7	-1.0	-0.4	0.4	0.4	-1.7
Patch foraging total patch changes 6 sec	0.8	1.1	3.7	-1.7	-0.4	0.1	-0.1	-0.2	-1.9
Patch foraging time to switch 0 sec	0.2	0.3	0.6	0.3	-0.6	-0.5	0.5	0.8	0.7
Patch foraging water rate 0 sec	0.1	0.2	0.6	-0.8	0.3	0.1	-0.1	-0.4	-0.6
Patch foraging water rate 12 sec	0.4	0.6	2.2	-1.0	-0.1	0.3	-0.3	-0.4	-1.5
Patch foraging water rate 18 sec	0.1	0.1	0.2	0.2	0.4	-0.0	0.0	-0.2	0.5
Patch foraging water rate 24 sec	0.4	0.6	0.8	-0.7	-0.3	-0.9	0.9	0.7	0.9
Patch foraging water rate 6 sec	0.1	0.1	0.2	-0.5	-0.0	-0.3	0.3	0.3	0.4
Seeking ratio, delayed vs. immediate footshock	1.6	1.8	3.8	2.0	1.4	1.3	-1.3	-1.2	0.3
Distance traveled before self-admin	1.3	1.4	5.4	0.6	-0.1	-1.0	1.0	0.9	2.3
Distance traveled after self-admin	0.5	0.6	2.4	0.7	0.1	-0.5	0.5	0.5	1.6
Extensor digitorum longus weight	1.0	4.0	9.9	-3.2	-2.0	-1.8	1.8	1.8	-0.6
Bone: elastic displacement	0.7	0.8	1.0	-0.5	-0.7	-1.0	1.0	1.0	0.9
Bone: elastic work	0.6	0.8	2.1	-0.4	-0.2	-0.9	0.9	0.8	1.5
Bone: endosteal estimation	0.3	0.5	1.5	-1.2	-0.7	-0.5	0.5	0.5	-0.7
Bone: endosteal perimeter	1.2	2.5	4.5	-2.1	-1.7	-1.6	1.6	1.6	-0.2
Epididymis fat weight	3.9	9.1	29.0	-5.4	-2.6	-2.0	2.0	1.7	-2.8
Delta time in closed arm before/after self-admin	0.6	0.6	1.1	1.1	0.9	0.7	-0.7	-0.6	0.5
Delta time in open arm before/after self-admin	1.0	0.9	3.7	-1.0	-0.9	0.0	-0.0	0.1	-1.9
Diff in mean of infusions in LGA sessions	0.7	0.8	1.5	-1.2	-1.1	-0.4	0.4	0.6	-1.1
Delay discount exponential model param	4.0	4.2	5.6	2.0	2.1	2.4	-2.4	-2.2	-0.7
Extinction: sum of active levers before priming	1.7	1.7	2.6	-1.3	-1.6	-1.5	1.5	1.2	-0.5
Active lever presses in extinction session 6	1.2	1.2	1.6	-1.3	-1.2	-1.2	1.2	1.0	-0.3
Bone: final force	0.2	0.4	0.8	-0.8	0.5	0.4	-0.4	-0.6	-0.9
Bone: final moment	0.2	0.4	0.9	-0.9	0.3	0.3	-0.3	-0.5	-0.9
Food consumed during 24 hour testing period	0.7	0.9	1.2	1.0	1.0	1.1	-1.1	-1.0	-0.3
Glucose	1.7	2.5	6.0	-2.5	-1.7	-1.4	1.4	1.4	-0.7
Heart weight	0.3	0.4	1.5	-1.2	-0.1	-0.6	0.6	0.2	-0.1
Delay discount hyperbolic model param	3.8	4.0	5.5	1.9	2.0	2.3	-2.3	-2.2	-0.9
Intermittent access intake day 1-15 change	2.0	1.9	2.7	-1.5	-1.6	-1.5	1.5	1.5	-0.1
Intermittent access intake escalation	1.0	1.0	1.5	-0.6	-0.9	-1.2	1.2	1.1	0.8
Intermittent access intake escalation 2	0.7	0.7	0.9	-0.6	-0.9	-1.0	1.0	0.9	0.4
Intermitt. access day 1 inactive lever presses	2.9	3.1	5.7	-2.4	-2.1	-1.5	1.5	1.5	-1.2
Intermitt. access day 15 inactive lever presses	0.7	0.7	1.3	-1.1	-0.9	-0.9	0.9	0.8	-0.2
Intermitt. access escalation Index	0.6	0.6	0.9	-0.3	-0.7	-1.0	1.0	0.8	0.5
Intermittent access day 1 total infusions	0.0	0.0	0.1	0.1	-0.0	0.1	-0.1	0.1	0.3
Intermittent access day 15 total infusions	0.9	1.0	1.4	-0.6	-1.0	-1.2	1.2	1.2	0.8
Intermittent access terminal intake (last 3 days)	0.6	0.7	1.0	-0.7	-0.9	-0.9	0.9	1.0	0.4
Intermittent access total infusions	0.2	0.2	0.4	-0.2	-0.5	-0.5	0.5	0.6	0.6
Intermittent access day 1 locomotion	0.5	0.6	2.1	0.4	-0.2	-0.6	0.6	0.7	1.4
Intermittent access day 15 total locomotion	1.3	1.4	2.3	-1.5	-1.3	-1.2	1.2	1.2	-0.3
Intermittent access total locomotion	0.4	0.5	1.5	0.1	-0.2	-0.7	0.7	0.6	1.2
Intermittent access standard deviation	0.7	0.7	1.4	-0.9	-1.2	-0.7	0.7	0.8	-0.7
Left kidney weight	0.3	0.9	2.5	0.1	1.6	0.2	-0.2	-0.7	1.4
Right kidney weight	0.2	0.6	2.0	-0.5	0.9	-0.4	0.4	-0.2	1.4
Cocaine induced anxiety	4.0	4.6	6.7	2.6	2.3	2.3	-2.3	-2.1	0.2
Post-drug Anxiety	1.6	1.8	2.2	1.3	1.5	1.5	-1.5	-1.5	-0.3
Baseline Anxiety	2.9	3.1	5.4	-2.3	-2.0	-1.7	1.7	1.5	-1.0
Tail length	0.3	1.0	1.8	-1.3	-1.3	-0.8	0.8	0.9	-0.7
Length with tail	0.4	1.4	4.0	-2.0	-1.1	-1.0	1.0	0.9	-0.6
Length without tail	0.1	0.3	1.3	-1.1	0.1	-0.0	0.0	-0.2	-0.6
Times rat made contact with spout	0.0	0.0	0.1	-0.0	0.2	0.3	-0.3	-0.1	-0.0
Lifetime Intake	0.1	0.1	0.2	0.3	-0.1	-0.0	0.0	0.2	0.5
Liver weight, left	2.8	4.4	8.2	-2.9	-2.4	-2.0	2.0	2.0	-0.6
Liver weight, right	4.1	6.7	12.1	-3.5	-2.8	-2.6	2.6	2.5	-0.5
Locomotor activity	0.1	0.1	0.2	-0.2	-0.3	-0.4	0.4	0.4	0.2
Locomotor testing distance	0.2	0.4	1.6	0.4	0.1	-0.4	0.4	0.4	1.3
Locomotor testing rearing	0.9	1.3	1.8	-0.5	-0.9	-1.4	1.4	1.3	1.3
Locomotion in novel chamber	0.3	0.3	1.1	0.7	0.6	0.2	-0.2	-0.1	1.0
Locomotion in novel chamber post-restriction	1.0	1.2	2.5	1.4	1.3	0.5	-0.5	-0.6	1.6
Fecal boli incidents, locomotor time 1	0.1	0.1	0.3	-0.1	0.1	0.4	-0.4	-0.3	-0.6
Change in fecal boli incidents, locomotor task	0.5	0.5	0.8	0.1	0.6	0.9	-0.9	-0.7	-0.7
Time >=10cm from walls, locomotor time 1	0.7	0.7	0.9	0.8	0.8	0.9	-0.9	-1.0	-0.5
Bouts of movement, locomotor time 1	1.2	1.3	2.1	-1.4	-1.4	-1.0	1.0	1.1	-0.6
Total resting periods, locomotor time 1	0.7	0.7	1.2	-1.1	-1.0	-0.8	0.8	0.9	-0.3
Rest time, locomotor task time 1	1.3	1.4	2.5	1.2	1.6	1.2	-1.2	-1.2	0.4
Distance moved, locomotor task time 1	0.6	0.7	1.0	-0.6	-0.9	-1.0	1.0	0.9	0.4
Vertical activity count, locomotor time 1	0.3	0.3	0.5	-0.2	-0.4	-0.6	0.6	0.6	0.7
Time >=10cm from walls, locomotor time 2	1.7	1.8	2.5	0.8	1.5	1.6	-1.6	-1.6	-0.7
Bouts of movement, locomotor time 2	1.0	1.1	1.6	-0.4	-1.1	-1.2	1.2	1.3	0.8
Total resting periods, locomotor time 2	1.6	1.7	2.5	-0.6	-1.4	-1.5	1.5	1.6	0.9
Rest time, locomotor task time 2	0.4	0.5	0.8	-0.2	-0.4	-0.8	0.8	0.7	0.9
Distance moved, locomotor task time 2	0.7	0.8	1.1	0.7	1.0	1.0	-1.0	-1.1	-0.5
Vertical activity count, locomotor time 2	0.8	0.9	1.3	0.7	1.0	1.1	-1.1	-1.1	-0.6
Light reinforcement 1	0.2	0.4	0.7	0.7	0.9	0.5	-0.5	-0.6	0.6
Light reinforcement 2	0.8	1.1	1.8	1.4	1.2	1.0	-1.0	-1.0	0.4
Bone: marrow area	0.3	0.6	1.6	-1.3	-0.7	-0.5	0.5	0.5	-0.7
Bone: maximum diameter	1.2	2.2	5.9	-2.4	-1.5	-0.9	0.9	0.8	-1.7
Bone: maximum force	0.5	0.8	1.4	-0.2	1.0	0.9	-0.9	-1.2	-1.0
Bone: maximum moment	0.5	0.8	1.2	-0.3	0.9	0.9	-0.9	-1.1	-1.1
Mean time between licks in bursts	0.4	0.5	2.4	-0.2	-0.3	0.5	-0.5	-0.3	-1.5
Mean num. licks in bursts	1.5	1.8	3.8	-0.4	-0.7	-1.5	1.5	1.4	2.0
Cd content in liver	4.8	5.3	6.8	2.2	2.2	2.5	-2.5	-2.6	-1.4
Co content in liver	2.0	2.3	3.9	1.7	2.0	1.4	-1.4	-1.7	0.2
Cu content in liver	0.1	0.1	0.2	0.3	0.1	-0.1	0.1	0.1	0.5
Fe content in liver	0.8	1.0	1.6	0.1	0.8	1.1	-1.1	-1.1	-1.3
K content in liver	0.6	0.6	0.9	-0.5	-0.9	-0.9	0.9	0.9	0.4
Mg content in liver	2.7	2.8	3.8	-1.3	-1.8	-1.9	1.9	1.9	0.8
Mn content in liver	0.5	0.6	0.9	-0.6	-0.6	-0.9	0.9	0.8	0.6
Na content in liver	2.7	2.8	3.5	-1.7	-1.9	-1.9	1.9	1.8	0.4
Rb content in liver	1.6	2.0	2.6	-1.2	-1.6	-1.6	1.6	1.6	0.4
Se content in liver	0.6	0.7	1.0	0.4	0.7	1.0	-1.0	-1.0	-1.0
Sr content in liver	0.6	0.5	1.6	1.1	0.6	-0.0	0.0	-0.1	1.3
Zn content in liver	1.8	2.0	6.4	0.3	-0.3	-1.4	1.4	1.2	2.5
Bone: minimum diameter	0.3	0.6	2.2	-1.5	-0.4	-0.2	0.2	0.0	-1.2
Time in familiar zone, hab. session 1	1.5	1.4	1.9	-1.0	-0.9	-1.4	1.4	1.2	1.1
Time in novel zone, hab. session 1	0.9	0.9	2.5	0.3	0.2	1.0	-1.0	-0.8	-1.6
Total zone transitions, hab. session 1	0.1	0.2	0.5	-0.4	-0.0	-0.5	0.5	0.3	0.7
Total locomotion distance, hab. session 1	1.2	1.7	2.2	0.7	1.1	1.5	-1.5	-1.5	-1.3
Locomotion velocity, hab. session 1	1.1	1.6	2.1	0.8	1.2	1.5	-1.5	-1.5	-1.1
Time in familiar zone, hab. session 2	0.5	0.5	1.6	-0.9	-0.8	-0.2	0.2	0.3	-1.3
Time in novel zone, hab. session 2	0.4	0.4	1.2	0.7	0.7	0.1	-0.1	-0.2	1.1
Total zone transitions, hab. session 2	0.4	0.5	0.8	-0.4	-0.4	-0.8	0.8	0.7	0.9
Total locomotion distance, hab. session 2	0.0	0.0	0.1	-0.1	0.2	0.2	-0.2	-0.3	-0.2
Locomotion velocity, hab. session 2	0.0	0.0	0.1	-0.2	0.1	-0.1	0.1	-0.0	-0.0
Novel to familiar place preference ratio	1.4	1.4	2.5	0.4	0.7	1.3	-1.3	-1.3	-1.6
Novelty place preference	1.0	1.0	1.9	0.3	0.6	1.1	-1.1	-1.0	-1.4
Time in novel zone, NPP test	1.0	1.1	3.1	-0.0	0.3	1.1	-1.1	-1.0	-1.8
Total zone transitions, NPP test	0.0	0.0	0.2	-0.1	0.1	-0.2	0.2	0.1	0.4
Total locomotion distance, NPP test	1.1	1.5	2.2	0.9	1.4	1.4	-1.4	-1.5	-0.6
Locomotion velocity, NPP test	1.5	2.1	3.0	1.4	1.7	1.6	-1.6	-1.7	-0.2
Intraocular pressure	0.7	1.0	4.0	-1.2	-0.7	-0.1	0.1	-0.1	-2.0
Delta distance traveled before/after self-admin	0.0	0.0	0.0	-0.1	-0.1	-0.1	0.1	0.1	-0.0
Delta ambulatory time before/after self-admin	0.1	0.1	0.3	0.0	0.1	0.2	-0.2	-0.2	-0.5
Parametrial fat weight	3.7	7.3	21.0	-4.6	-2.6	-1.9	1.9	1.7	-2.5
Pavlov. Cond. lever latency	0.2	0.2	0.5	-0.4	-0.7	-0.2	0.2	0.4	-0.7
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	0.0	0.1	-0.1	0.1	-0.0	0.3
Pavlov. Cond. change in total contacts	0.3	0.4	0.5	-0.6	-0.4	-0.7	0.7	0.6	0.5
Pavlov. Cond. index score	0.1	0.1	0.2	-0.4	-0.2	-0.4	0.4	0.3	0.3
Pavlov. Cond. latency score	0.0	0.1	0.1	-0.2	-0.0	-0.3	0.3	0.2	0.4
Pavlov. Cond. lever contacts	0.1	0.1	0.1	-0.3	-0.1	-0.3	0.3	0.2	0.3
Pavlov. Cond. magazine entry number	0.3	0.4	0.5	0.6	0.6	0.7	-0.7	-0.7	-0.3
Pavlov. Cond. intertrial magazine entries	1.1	1.3	2.0	0.6	1.4	1.3	-1.3	-1.4	-0.5
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	-0.4	-0.2	-0.4	0.4	0.4	0.3
Pavlov. Cond. response bias	0.1	0.1	0.4	-0.1	-0.0	-0.4	0.4	0.3	0.6
Pavlov. Cond. lever latency	0.5	0.7	2.8	0.9	0.5	-0.3	0.3	0.2	1.7
Pavlov. Cond. magazine entry latency	0.8	0.9	1.7	-1.1	-1.3	-0.9	0.9	1.0	-0.4
Pavlov. Cond. change in total contacts	0.3	0.5	1.0	-0.9	-0.8	-0.3	0.3	0.4	-1.0
Pavlov. Cond. index score	0.5	0.7	1.3	-1.1	-1.0	-0.5	0.5	0.6	-1.0
Pavlov. Cond. latency score	0.4	0.5	1.0	-1.0	-0.9	-0.3	0.3	0.5	-1.0
Pavlov. Cond. lever contacts	0.3	0.4	1.3	-0.8	-0.5	0.1	-0.1	0.1	-1.1
Pavlov. Cond. magazine entry number	0.4	0.5	0.9	0.9	1.0	0.7	-0.7	-0.7	0.3
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.3	-0.6	0.1	0.1	-0.1	-0.2	-0.5
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	1.1	-1.0	-1.0	-0.5	0.5	0.6	-0.8
Pavlov. Cond. response bias	0.4	0.6	1.8	-1.0	-0.8	-0.1	0.1	0.2	-1.4
Time in closed arm before self-admin	1.7	1.9	3.0	-0.9	-1.2	-1.7	1.7	1.5	1.1
Time in closed arm after self-admin	1.0	1.0	2.5	0.3	-0.4	-1.2	1.2	0.9	1.6
Time in open arm before self-admin	3.1	3.3	5.0	1.7	1.8	2.2	-2.2	-1.9	-0.6
Time in open arm after self-admin	1.2	1.3	3.3	-0.0	0.3	1.3	-1.3	-0.9	-1.8
Bone: periosteal estimation	0.3	0.6	2.0	-1.4	-0.1	0.1	-0.1	-0.2	-1.3
Bone: periosteal perimeter	1.7	2.8	6.8	-2.6	-1.7	-1.5	1.5	1.4	-0.6
Bone: post-yield work	2.0	2.7	3.7	0.5	1.4	1.8	-1.8	-1.9	-1.9
Progressive ratio test 1 active lever presses	0.6	0.6	0.9	-0.1	-0.8	-0.9	0.9	0.9	0.8
Progressive ratio test 1 breakpoint	0.3	0.3	0.5	-0.1	-0.6	-0.6	0.6	0.7	0.5
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.2	-0.2	-0.4	-0.2	0.2	0.2	-0.5
Progressive ratio test 2 active lever presses	2.2	2.4	3.3	-1.4	-1.5	-1.8	1.8	1.7	0.8
Progressive ratio test 2 breakpoint	2.9	3.3	4.5	-1.7	-1.8	-2.1	2.1	2.0	0.8
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.6	-0.2	-0.2	0.1	-0.1	-0.1	-0.8
Incentive Sensitization - Responses	5.0	5.0	6.8	-2.4	-2.2	-2.6	2.6	2.3	0.6
Incentive Sensitization - Breakpoint	4.9	4.9	6.6	-2.5	-2.2	-2.6	2.6	2.3	0.4
Sum of active levers in priming session hrs 5-6	1.1	1.0	2.1	-1.1	-1.4	-0.9	0.9	1.0	-0.7
Progressive ratio	2.3	2.7	3.7	1.9	1.5	1.8	-1.8	-1.7	-0.6
Food seeking constrained by brief footshock	0.3	0.4	1.0	1.0	0.5	0.6	-0.6	-0.6	-0.1
Seeking ratio, punishment vs. effort	1.3	1.5	2.2	-1.0	-1.0	-1.5	1.5	1.3	1.1
Retroperitoneal fat weight	4.0	13.3	43.4	-6.6	-3.0	-2.7	2.7	2.2	-2.7
Reaction time number correct	1.5	2.1	2.8	-1.3	-1.7	-1.6	1.6	1.7	0.4
Reaction time mean minus median	2.4	3.1	3.9	-1.8	-1.9	-2.0	2.0	1.9	0.5
Reaction time mean minus median AUC	4.7	6.1	8.2	-1.8	-2.4	-2.9	2.9	2.8	1.8
Reaction time num false alarms	0.4	0.5	1.0	0.7	1.0	0.6	-0.6	-0.8	0.2
Reaction time num false alarms AUC	0.3	0.3	0.7	0.7	0.9	0.3	-0.3	-0.6	0.6
Reaction time trials correct on left	1.5	2.1	2.8	-1.3	-1.7	-1.6	1.6	1.7	0.4
Reaction time trials on left	1.7	2.4	3.2	-1.4	-1.8	-1.7	1.7	1.8	0.4
Reaction time mean	4.0	5.6	7.6	-1.6	-2.4	-2.7	2.7	2.8	1.6
Reaction time mean AUC	4.8	6.5	8.9	-1.7	-2.6	-2.9	2.9	3.0	1.8
Median of all reaction times	4.0	5.4	7.5	-1.3	-2.3	-2.7	2.7	2.7	1.9
Reaction time omissions	2.5	3.4	4.7	-2.1	-2.2	-1.9	1.9	2.0	0.1
Reaction time false alarm rate	1.2	1.7	2.9	1.3	1.7	1.3	-1.3	-1.5	-0.0
Reaction time premature initiation rate	0.1	0.2	0.4	0.4	0.6	-0.0	0.0	-0.3	0.7
Reaction time premature initiations	0.4	0.5	0.9	-0.4	-0.4	-0.9	0.9	0.7	0.9
Std. dev. reaction times	3.5	4.9	6.3	-2.2	-2.4	-2.5	2.5	2.4	0.7
Reaction time trials completed	1.7	2.4	3.2	-1.4	-1.8	-1.7	1.7	1.8	0.4
Reaction time trials AUC	1.5	2.2	3.0	-1.4	-1.7	-1.6	1.6	1.7	0.3
Run reversals in cocaine runway, females	0.1	0.1	0.3	-0.4	-0.4	-0.2	0.2	0.1	-0.6
Run reversals in cocaine runway, males	0.4	0.4	1.6	0.5	0.2	-0.4	0.4	0.2	1.2
Latency to leave start box in cocaine runway	2.4	2.6	3.7	-1.1	-1.9	-1.9	1.9	1.8	0.4
Latency to leave start box in cocaine runway, F	1.9	2.1	3.0	-1.3	-1.7	-1.7	1.7	1.6	0.1
Latency to leave start box in cocaine runway, M	1.3	1.2	1.8	-0.3	-1.0	-1.3	1.3	1.2	1.0
Std. dev. time between licks in bursts	2.1	2.5	3.2	1.3	1.3	1.8	-1.8	-1.8	-1.3
Total sessions with >9 infusions	0.2	0.2	0.9	0.6	0.4	-0.0	0.0	-0.0	1.0
Short access day 1 total inactive lever presses	0.4	0.4	0.8	0.3	0.3	0.7	-0.7	-0.7	-0.9
Short access day 10 total inactive lever presses	0.3	0.4	1.0	-1.0	-0.5	-0.5	0.5	0.3	-0.7
Short access day 1 total infusions	0.1	0.2	0.5	0.0	-0.1	-0.4	0.4	0.3	0.7
Short access day 10 total infusions	0.2	0.3	0.9	0.7	0.1	-0.1	0.1	0.2	1.0
Short access total infusions	0.2	0.2	0.6	0.7	0.3	0.1	-0.1	-0.0	0.7
Short access day 1 locomotion	0.6	0.7	1.1	-0.5	-0.9	-1.0	1.0	0.9	0.4
Short access day 10 total locomotion	0.3	0.3	0.8	0.1	-0.1	-0.6	0.6	0.4	0.9
Short access total locomotion	0.9	0.9	3.8	0.7	0.2	-0.6	0.6	0.5	2.0
One hour access (0.3 mA shock)	1.1	1.2	2.4	-1.2	-1.5	-1.0	1.0	1.1	-0.7
Compulsive drug intake	0.1	0.1	0.6	-0.3	-0.1	-0.0	0.0	-0.2	-0.8
One hour access (shock baseline)	0.1	0.2	0.3	-0.1	-0.5	-0.3	0.3	0.6	0.3
Social response proportion	0.4	0.5	1.2	-0.3	-0.0	-0.8	0.8	0.5	1.1
Social responses	0.3	0.4	1.4	-1.2	-0.4	-0.5	0.5	0.3	-0.4
Social time	2.4	3.2	4.2	-1.2	-1.5	-2.1	2.1	2.0	1.7
Soleus weight	4.8	14.1	18.6	-3.5	-3.4	-4.3	4.3	4.2	2.5
Bone: stiffness	0.8	1.2	1.8	0.1	1.1	1.2	-1.2	-1.4	-1.2
Tibialis anterior weight	1.6	5.5	7.9	-2.8	-2.6	-2.4	2.4	2.6	0.3
Time to tail flick, vehicle, before self-admin	1.2	1.3	1.9	0.3	0.9	1.3	-1.3	-1.3	-1.4
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.1	-0.1	0.3	0.2	-0.2	-0.2	-0.1
Time to tail flick, test, before self-admin	0.7	0.7	1.7	1.3	0.8	0.2	-0.2	-0.3	1.2
Time to tail flick, test, after self-admin	0.5	0.6	1.1	-1.0	-0.9	-0.3	0.3	0.4	-1.1
Delta time to tail flick, vehicle, before/after SA	1.4	1.3	1.7	-1.2	-1.1	-1.3	1.3	1.3	0.6
Delta time to tail flick, test, before/after SA	0.9	0.8	2.8	-1.2	-0.6	0.2	-0.2	-0.0	-1.7
Tibia length	0.1	0.2	0.5	0.2	0.7	0.5	-0.5	-0.6	-0.1
Ambulatory time before self-admin	0.6	0.6	2.4	0.6	0.0	-0.6	0.6	0.5	1.6
Ambulatory time after self-admin	0.4	0.5	1.6	0.5	-0.2	-0.6	0.6	0.6	1.3
Bone: tissue strength	0.0	0.0	0.1	0.1	-0.1	0.1	-0.1	-0.0	-0.3
Total heroin consumption	1.7	2.0	4.0	-2.0	-1.6	-1.2	1.2	1.1	-1.1
Bone: trabecular number	0.7	1.1	4.5	-1.1	-0.1	0.6	-0.6	-0.6	-2.1
Bone: trabecular spacing	0.1	0.1	0.5	0.7	0.0	0.2	-0.2	-0.1	0.1
Bone: trabecular thickness	1.0	1.2	4.1	-2.0	-0.9	-0.6	0.6	0.6	-1.1
Bone: trabecular tissue density	0.9	1.2	3.8	0.4	-0.4	-1.0	1.0	1.1	2.0
Water consumed over 24 hours	0.2	0.3	0.6	0.7	0.5	0.3	-0.3	-0.2	0.7
Number of responses in last shaping day	0.0	0.0	0.0	0.2	-0.0	0.1	-0.1	0.0	0.0