Hub : Genes

Usp35

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Usp35 0.08 0.04 2.1e-07 0.06 0.05 0.05 0.05 8.1e-07 1.8e-06 3.8e-06 2.5e-06
2 Brain alternative TSS XM_238899.9 0.04 0.03 1.1e-03 0.02 0.03 0.03 0.03 2.3e-03 5.1e-04 8.0e-04 1.8e-03
3 PL alternative TSS XM_039101069.1 0.03 0.02 3.8e-03 0.04 0.01 0.03 0.03 7.3e-05 1.1e-02 1.7e-04 2.7e-04
4 PL alternative TSS XM_039101069.1 0.03 0.02 1.5e-03 0.03 0.03 0.03 0.03 2.3e-04 3.7e-04 2.7e-04 2.9e-04
5 PL alternative TSS XM_238899.9 0.04 0.03 3.3e-03 0.04 0.01 0.03 0.03 5.8e-05 1.3e-02 3.5e-04 2.9e-04
6 PL gene expression Usp35 0.04 0.03 3.7e-04 0.02 0.03 0.03 0.03 3.3e-03 1.7e-04 4.7e-04 5.1e-04
7 PL alternative TSS XM_039101071.1 0.03 0.02 2.9e-03 0.01 0.02 0.02 0.01 2.1e-02 3.0e-03 5.4e-03 1.3e-02
8 Brain alternative TSS XM_039101073.1 0.05 0.03 2.5e-04 0.02 0.02 0.03 0.03 4.1e-03 2.9e-03 5.2e-04 1.4e-03
9 LHb alternative TSS XM_039101073.1 0.17 0.11 6.2e-03 0.13 0.04 0.13 0.12 6.4e-04 3.8e-02 4.9e-04 7.1e-04
10 PL isoform ratio XM_039101070.1 0.03 0.02 5.1e-03 0.01 0.01 0.01 0.02 9.8e-03 7.8e-03 3.6e-02 6.1e-03
11 PL alternative TSS XM_039101073.1 0.04 0.02 6.7e-04 0.03 0.02 0.02 0.03 1.7e-04 9.1e-04 4.8e-03 5.0e-04
12 Brain gene expression Usp35 0.07 0.04 1.8e-04 0.04 0.03 0.03 0.02 2.3e-04 2.1e-03 2.1e-03 2.5e-03
13 Adipose gene expression Usp35 0.05 0.03 9.1e-04 0.01 0.01 0 0.01 9.7e-03 9.7e-03 2.4e-01 5.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.20.30.7-0.3-0.40.30.3-0.30.40.5-0.7-0.6-0.6-0.8-0.9-0.4
Area under the delay curve0.30.30.80.90.80.60.6-0.60.7-0.4-0.2-0.5-0.2-0.1-0.2-0.3
BMI with tail0.72.26.0-0.90.5-1.2-1.21.2-2.5-1.41.62.01.71.31.3-1.6
BMI without tail3.67.520.3-1.10.8-1.6-1.61.6-4.5-2.53.63.93.53.23.1-1.3
Body weight1.98.019.2-1.31.4-1.8-1.81.8-4.4-3.03.53.93.52.92.7-2.6
Weight adjusted by age1.21.43.00.50.9-0.4-0.40.4-0.7-1.21.71.71.71.51.41.1
Bone surface0.71.33.21.51.21.81.8-1.81.0-0.80.30.30.50.30.01.0
Bone volume0.60.92.21.21.21.51.5-1.50.5-1.00.50.50.70.40.30.5
Breakpoint value in progressive ratio session0.20.20.60.1-0.2-0.1-0.10.10.70.5-0.6-0.6-0.5-0.7-0.80.3
Number of licking bursts1.21.43.9-2.0-1.3-1.7-1.71.7-1.30.7-0.20.1-0.2-0.2-0.3-1.2
Context. condit. distance diff. score2.12.66.71.91.02.62.6-2.62.1-0.2-0.5-0.7-0.3-0.5-0.41.8
Locomotion velocity, session 10.80.92.40.8-0.20.30.3-0.31.60.8-1.2-1.3-1.2-1.0-0.90.8
Locomotion distance, session 10.30.41.30.90.20.50.5-0.51.00.3-0.3-0.6-0.5-0.1-0.11.2
Locomotion velocity, session 20.20.31.41.20.70.30.3-0.30.6-0.40.20.00.20.20.20.7
Locomotion distance, session 20.20.30.90.20.4-0.9-0.90.9-0.3-0.40.20.10.10.20.2-0.7
Locomotion velocity, session 30.20.20.70.60.30.80.8-0.80.6-0.0-0.2-0.3-0.2-0.1-0.20.3
Locomotion distance, session 31.31.43.21.50.71.71.7-1.71.80.1-0.7-1.0-0.7-0.5-0.61.1
Stereotopy head waving bouts, day 31.41.74.5-2.1-1.8-1.9-1.91.9-1.51.00.00.50.2-0.1-0.2-0.4
Stereotopy head waving duration, day 30.50.52.4-0.7-0.3-1.0-1.01.0-0.40.2-0.4-0.3-0.4-0.5-0.5-1.6
Locomotion velocity, session 70.10.10.50.50.3-0.1-0.10.10.7-0.0-0.3-0.3-0.2-0.4-0.30.3
Locomotion distance, session 70.40.51.21.11.00.60.6-0.60.5-0.80.50.40.60.50.50.9
Stereotopy head waving bouts, day 70.40.40.8-0.1-0.7-0.4-0.40.40.80.9-0.8-0.7-0.6-0.9-0.70.7
Stereotopy head waving duration, day 70.10.10.30.50.20.30.3-0.30.5-0.0-0.2-0.2-0.1-0.4-0.20.2
Locomotion velocity, session 82.32.87.52.71.92.02.0-2.02.7-0.7-0.9-1.1-0.7-1.1-1.00.5
Locomotion distance, session 80.71.02.51.61.01.41.4-1.41.4-0.4-0.2-0.4-0.1-0.4-0.20.8
Degree of sensitization distance1.41.43.2-0.10.5-0.5-0.50.5-1.6-1.11.71.81.61.51.60.2
Degree of sensitization stereotypy1.01.13.71.20.10.90.9-0.91.90.5-1.0-1.1-0.8-1.0-0.91.4
Conditioned locomotion0.20.31.4-0.10.10.00.0-0.00.20.1-0.6-0.7-0.7-0.5-0.6-1.2
Cocaine response after cond. corrected0.50.51.50.20.21.21.2-1.20.1-0.20.50.40.40.60.61.1
Cocaine response after cond. not corrected0.50.61.80.0-0.31.31.3-1.30.60.4-0.1-0.1-0.10.00.01.3
Cocaine response before conditioning0.91.12.4-0.7-1.4-0.4-0.40.40.81.6-1.3-1.1-1.1-1.3-1.10.7
Saline control response1.31.73.71.11.91.01.0-1.0-1.0-1.91.51.21.21.21.5-1.0
Bone: connectivity density0.71.12.70.3-0.50.90.9-0.91.71.0-1.3-1.2-1.1-1.1-1.30.9
Bone: cortical apparent density0.10.11.0-0.4-0.00.00.0-0.0-0.7-0.20.20.20.10.10.2-1.0
Bone: cortical area0.71.02.00.81.30.60.6-0.6-0.4-1.41.31.41.41.01.00.5
Bone: cortical porosity0.30.30.6-0.3-0.70.10.1-0.10.50.8-0.7-0.6-0.7-0.6-0.60.4
Bone: cortical porosity0.40.41.1-0.4-1.0-0.0-0.00.00.51.0-0.7-0.6-0.7-0.6-0.60.8
Bone: cortical thickness0.00.10.2-0.3-0.1-0.3-0.30.3-0.3-0.10.30.40.30.20.10.2
Bone: cortical thickness1.01.24.01.10.61.71.7-1.71.0-0.20.2-0.00.10.40.42.0
Bone: cortical tissue density0.10.11.0-0.4-0.10.00.0-0.0-0.7-0.10.10.1-0.00.00.2-1.0
Condit. Reinf. active minus inactive responses1.41.63.10.31.00.70.7-0.7-1.4-1.41.81.71.51.81.7-0.2
Condit. Reinf. active-inactive response ratio1.41.62.70.10.91.01.0-1.0-1.4-1.41.61.61.41.61.5-0.5
Condit. Reinf. active responses0.60.71.70.00.5-0.1-0.10.1-1.2-0.91.21.21.01.31.1-0.4
Condit. Reinf. inactive responses0.10.10.40.1-0.1-0.6-0.60.6-0.10.10.0-0.10.00.1-0.10.1
Incentive salience index mean1.01.22.40.81.10.70.7-0.7-0.8-1.31.51.41.31.51.40.4
Condit. Reinf. lever presses0.20.31.41.20.80.30.3-0.30.5-0.60.30.20.30.40.30.6
Condit. Reinf. active minus inactive responses3.84.78.92.73.02.22.2-2.2-0.2-2.82.31.82.12.12.11.0
Condit. Reinf. active-inactive response ratio1.51.63.91.92.01.31.3-1.30.4-1.61.10.71.01.11.00.6
Condit. Reinf. active responses5.06.913.03.03.62.32.3-2.3-0.6-3.53.02.52.82.82.80.9
Condit. Reinf. inactive responses2.22.75.11.21.90.70.7-0.7-1.3-2.22.22.12.12.02.10.0
Condit. Reinf. lever presses5.16.918.73.94.33.23.2-3.21.1-3.41.71.01.51.61.50.1
Condit. Reinf. lever reinforcers received5.17.213.43.23.72.62.6-2.6-0.4-3.52.92.42.72.72.71.1
Conditioned reinforcement - actives2.52.57.91.1-0.12.12.1-2.12.40.8-0.9-0.9-0.7-0.8-0.92.8
Conditioned reinforcement - inactives0.80.82.7-0.7-0.7-1.7-1.71.70.40.7-0.5-0.2-0.2-0.6-0.60.4
Conditioned locomotion1.62.06.20.8-0.31.41.4-1.42.51.0-1.2-1.1-0.8-1.3-1.22.2
Patch foraging indifference point 0 sec1.01.54.21.62.01.31.3-1.3-0.1-1.81.20.91.01.00.8-0.4
Patch foraging indifference point AUC0.20.20.70.60.50.20.2-0.2-0.1-0.50.60.50.50.80.50.6
Delay disc. indifference point, 0s delay0.30.41.70.60.30.10.1-0.10.2-0.30.70.60.70.80.61.3
Delay disc. indifference point, 16s delay0.60.61.50.70.80.50.5-0.50.7-0.2-0.8-1.2-0.9-0.6-0.4-1.2
Delay disc. indifference point, 2s delay0.10.10.60.60.50.00.0-0.00.7-0.20.10.10.20.0-0.20.5
Delay disc. indifference point, 24s delay0.30.21.90.20.4-0.0-0.00.00.1-0.2-0.4-0.6-0.5-0.4-0.4-1.4
Delay disc. indifference point, 4s delay0.70.72.01.21.40.50.5-0.50.2-1.30.90.81.00.70.60.2
Delay disc. indifference point, 8s delay0.80.82.21.21.01.51.5-1.50.9-0.5-0.2-0.5-0.3-0.1-0.1-0.2
Indifference point function ln k0.40.51.60.30.30.40.4-0.40.70.1-0.9-1.0-0.8-1.3-0.6-0.9
Indifference point function log k0.40.51.60.30.30.40.4-0.40.70.1-0.9-1.0-0.8-1.3-0.6-0.9
Patch foraging total patch changes 0 sec0.91.43.91.62.01.41.4-1.40.1-1.71.00.80.80.80.7-0.4
Patch foraging total patch changes 12 sec0.81.02.30.90.80.60.6-0.6-0.2-0.91.31.31.41.20.81.5
Patch foraging total patch changes 18 sec1.62.03.31.81.71.51.5-1.5-0.2-1.71.51.21.31.61.20.9
Patch foraging total patch changes 24 sec1.41.72.91.30.91.51.5-1.5-0.2-1.01.31.11.21.61.21.7
Patch foraging total patch changes 6 sec0.10.21.70.10.70.10.1-0.1-0.2-0.60.10.0-0.10.1-0.3-1.3
Patch foraging time to switch 0 sec2.03.06.7-2.4-2.6-2.4-2.42.4-0.52.1-1.2-0.7-1.0-1.2-1.2-0.2
Patch foraging water rate 0 sec1.21.94.22.11.92.02.0-2.00.9-1.40.70.30.50.90.80.7
Patch foraging water rate 12 sec0.71.13.41.61.81.31.3-1.30.6-1.30.2-0.40.00.20.4-0.8
Patch foraging water rate 18 sec1.01.33.31.21.81.41.4-1.4-0.1-1.50.90.40.50.91.2-0.5
Patch foraging water rate 24 sec0.50.61.41.11.00.50.5-0.51.2-0.4-0.7-1.0-0.8-0.7-0.5-0.9
Patch foraging water rate 6 sec0.30.51.00.90.70.70.7-0.71.0-0.1-0.5-0.9-0.8-0.5-0.2-0.4
Seeking ratio, delayed vs. immediate footshock0.10.10.5-0.3-0.7-0.2-0.20.20.40.6-0.3-0.2-0.2-0.2-0.10.7
Distance traveled before self-admin0.00.00.1-0.3-0.1-0.2-0.20.2-0.30.00.0-0.10.00.10.0-0.4
Distance traveled after self-admin1.11.21.8-1.4-1.2-1.2-1.21.2-0.11.2-1.1-1.0-1.1-1.0-0.9-1.1
Extensor digitorum longus weight0.41.63.60.31.6-0.3-0.30.3-1.4-1.91.61.61.51.21.1-1.3
Bone: elastic displacement0.50.61.0-0.7-0.6-1.0-1.01.00.20.7-0.8-0.8-0.9-0.7-0.7-0.7
Bone: elastic work1.31.63.2-0.7-0.9-0.8-0.80.81.11.3-1.8-1.7-1.8-1.6-1.7-0.8
Bone: endosteal estimation1.12.43.71.81.91.21.2-1.2-0.4-1.91.91.71.91.71.71.0
Bone: endosteal perimeter1.32.76.52.42.61.31.3-1.30.2-2.31.71.41.71.41.40.7
Epididymis fat weight1.53.58.9-1.4-0.1-1.0-1.01.0-2.8-1.22.53.02.72.31.80.4
Delta time in closed arm before/after self-admin2.62.55.31.22.21.31.3-1.3-1.4-2.31.51.11.21.41.6-2.1
Delta time in open arm before/after self-admin0.60.61.90.90.70.80.8-0.80.4-0.60.70.70.80.70.41.4
Diff in mean of infusions in LGA sessions1.71.84.1-1.8-1.1-2.0-2.02.0-1.20.6-0.40.1-0.4-0.6-0.7-2.0
Delay discount exponential model param0.30.30.8-0.9-0.8-0.7-0.70.7-0.70.40.30.50.30.20.20.3
Extinction: sum of active levers before priming0.50.50.80.60.90.70.7-0.7-0.3-0.90.80.70.70.70.7-0.2
Active lever presses in extinction session 60.50.51.80.2-0.40.40.4-0.41.10.8-0.6-0.7-0.6-0.5-0.51.3
Bone: final force0.10.20.50.20.30.40.4-0.40.7-0.0-0.4-0.3-0.2-0.5-0.60.1
Bone: final moment0.10.10.40.30.30.40.4-0.40.6-0.1-0.3-0.1-0.1-0.4-0.50.2
Food consumed during 24 hour testing period0.81.02.11.20.41.41.4-1.41.40.2-0.8-0.8-0.5-1.0-0.90.3
Glucose0.10.20.50.50.70.20.2-0.20.5-0.5-0.2-0.10.1-0.5-0.6-0.5
Heart weight0.81.22.61.41.31.61.6-1.60.6-0.90.60.20.40.90.80.9
Delay discount hyperbolic model param0.30.31.0-1.0-0.9-0.7-0.70.7-0.70.50.00.30.1-0.00.00.0
Intermittent access intake day 1-15 change0.50.52.51.20.6-0.3-0.30.31.60.1-0.6-0.7-0.5-0.6-0.70.7
Intermittent access intake escalation0.50.52.41.40.80.10.1-0.11.6-0.2-0.5-0.6-0.3-0.4-0.50.7
Intermittent access intake escalation 20.20.21.50.40.1-0.1-0.10.10.60.00.10.20.30.1-0.11.2
Intermitt. access day 1 inactive lever presses0.80.82.0-1.0-1.4-1.2-1.21.20.01.1-0.30.0-0.0-0.3-0.41.2
Intermitt. access day 15 inactive lever presses0.90.93.7-0.3-0.2-1.9-1.91.90.20.3-0.4-0.3-0.2-0.6-0.3-0.2
Intermitt. access escalation Index1.11.03.0-0.9-0.6-1.7-1.71.7-0.10.4-0.6-0.4-0.4-0.6-0.7-1.1
Intermittent access day 1 total infusions0.70.82.20.90.91.51.5-1.50.6-0.70.40.40.50.30.20.6
Intermittent access day 15 total infusions0.91.03.81.50.91.11.1-1.12.0-0.2-0.5-0.5-0.2-0.5-0.71.1
Intermittent access terminal intake (last 3 days)0.50.61.80.90.50.90.9-0.91.3-0.1-0.10.00.3-0.2-0.51.3
Intermittent access total infusions0.60.72.80.70.31.21.2-1.21.2-0.0-0.10.20.4-0.2-0.31.7
Intermittent access day 1 locomotion0.70.71.7-0.2-0.80.60.6-0.61.31.0-0.9-0.6-0.5-0.9-1.11.2
Intermittent access day 15 total locomotion0.40.51.31.00.60.80.8-0.81.1-0.2-0.1-0.10.2-0.1-0.21.1
Intermittent access total locomotion0.30.41.50.40.10.90.9-0.90.90.0-0.10.20.3-0.3-0.31.2
Intermittent access standard deviation0.20.21.3-0.2-0.4-0.5-0.50.50.20.20.10.30.40.1-0.11.2
Left kidney weight1.33.57.30.91.70.60.6-0.6-1.9-2.32.72.72.62.32.40.2
Right kidney weight0.82.45.20.41.20.10.1-0.1-1.9-1.82.32.22.02.11.9-0.2
Cocaine induced anxiety0.81.02.4-1.2-0.9-1.6-1.61.6-0.70.6-0.4-0.2-0.4-0.6-0.4-1.1
Post-drug Anxiety0.10.10.50.10.20.10.1-0.1-0.5-0.30.20.1-0.00.10.3-0.7
Baseline Anxiety1.92.05.42.01.62.32.3-2.30.9-1.10.50.10.30.70.70.8
Tail length3.09.119.30.62.20.10.1-0.1-3.8-3.54.44.44.24.03.8-0.0
Length with tail1.76.413.7-0.51.5-1.0-1.01.0-3.6-2.83.53.73.52.92.7-1.5
Length without tail0.30.84.1-0.9-0.1-1.1-1.11.1-0.30.0-0.4-0.3-0.4-0.5-0.7-2.0
Times rat made contact with spout0.40.51.4-0.9-0.5-0.7-0.70.7-1.2-0.00.40.80.60.10.2-0.7
Lifetime Intake0.91.03.51.00.41.51.5-1.51.3-0.1-0.00.10.2-0.1-0.11.9
Liver weight, left0.71.12.3-0.90.2-1.0-1.01.0-1.5-0.91.01.41.30.60.4-1.3
Liver weight, right2.44.09.4-2.7-1.1-2.4-2.42.4-3.1-0.41.62.52.11.10.9-1.1
Locomotor activity0.40.61.90.10.40.30.3-0.3-1.4-0.70.80.60.41.01.1-1.0
Locomotor testing distance1.62.75.01.51.71.21.2-1.2-1.4-1.92.11.61.62.22.20.3
Locomotor testing rearing2.03.16.30.51.2-0.3-0.30.3-2.3-1.92.52.52.32.42.40.0
Locomotion in novel chamber0.91.13.50.4-0.5-0.2-0.20.21.91.0-1.4-1.1-0.7-1.4-1.70.5
Locomotion in novel chamber post-restriction1.41.76.11.50.71.21.2-1.22.50.2-1.3-1.4-1.0-1.4-1.50.1
Fecal boli incidents, locomotor time 12.42.68.02.10.62.32.3-2.32.10.2-0.2-0.8-0.40.30.32.8
Change in fecal boli incidents, locomotor task1.51.44.8-1.5-0.8-1.5-1.51.5-1.10.4-0.6-0.4-0.6-0.8-0.6-2.2
Time >=10cm from walls, locomotor time 10.60.61.80.90.30.80.8-0.81.30.3-0.8-1.1-0.8-0.7-0.70.3
Bouts of movement, locomotor time 10.40.41.70.61.2-0.4-0.40.40.1-1.00.1-0.20.10.10.1-1.3
Total resting periods, locomotor time 10.40.41.90.40.9-0.4-0.40.40.4-0.5-0.4-0.6-0.4-0.5-0.4-1.4
Rest time, locomotor task time 10.40.40.90.70.50.00.0-0.00.90.1-0.7-1.0-0.8-0.8-0.5-0.7
Distance moved, locomotor task time 11.11.22.60.40.60.40.4-0.4-1.0-1.01.51.41.51.61.41.0
Vertical activity count, locomotor time 10.60.71.40.20.50.60.6-0.6-0.7-0.81.11.01.11.20.90.5
Time >=10cm from walls, locomotor time 20.60.61.31.10.81.01.0-1.00.4-0.70.60.40.60.80.60.9
Bouts of movement, locomotor time 20.20.20.40.20.4-0.6-0.60.6-0.4-0.60.50.60.60.30.3-0.3
Total resting periods, locomotor time 20.10.10.10.20.3-0.3-0.30.3-0.2-0.30.30.40.30.20.2-0.1
Rest time, locomotor task time 20.91.12.5-1.1-1.6-0.9-0.90.90.11.5-1.2-1.0-1.1-1.1-0.8-0.1
Distance moved, locomotor task time 22.12.43.61.41.51.71.7-1.7-0.0-1.51.71.61.91.71.41.5
Vertical activity count, locomotor time 21.92.03.21.11.31.31.3-1.3-0.5-1.51.81.61.81.81.61.2
Light reinforcement 10.61.02.8-1.7-1.3-1.5-1.51.5-1.30.60.20.50.10.20.1-0.2
Light reinforcement 20.20.30.9-0.8-0.9-0.6-0.60.60.20.8-0.4-0.2-0.4-0.4-0.50.5
Bone: marrow area1.02.13.31.61.71.11.1-1.1-0.4-1.81.81.61.81.61.60.9
Bone: maximum diameter0.91.74.71.72.20.90.9-0.90.0-2.01.41.31.51.11.10.3
Bone: maximum force0.20.41.20.60.50.60.6-0.61.1-0.1-0.6-0.5-0.4-0.8-0.90.0
Bone: maximum moment0.20.31.10.60.60.60.6-0.61.0-0.2-0.5-0.3-0.3-0.6-0.80.1
Mean time between licks in bursts2.53.66.51.71.81.21.2-1.2-0.6-2.02.42.42.52.22.21.8
Mean num. licks in bursts0.91.12.91.71.21.51.5-1.50.9-0.80.40.20.50.20.30.9
Cd content in liver0.20.20.6-0.5-0.1-0.1-0.10.1-0.8-0.20.50.60.50.50.5-0.1
Co content in liver1.31.62.81.71.50.90.9-0.9-0.1-1.51.41.21.31.41.41.1
Cu content in liver2.02.44.01.11.61.31.3-1.3-1.3-1.92.01.71.72.02.00.1
Fe content in liver0.50.62.70.70.31.01.0-1.00.7-0.10.30.20.40.30.31.6
K content in liver0.30.30.7-0.8-0.8-0.6-0.60.6-0.70.40.00.20.0-0.0-0.0-0.4
Mg content in liver0.10.10.50.20.20.70.7-0.7-0.1-0.20.20.20.20.20.2-0.0
Mn content in liver1.31.53.1-1.2-1.6-0.4-0.40.40.71.7-1.6-1.4-1.4-1.5-1.5-0.1
Na content in liver1.01.02.8-0.8-1.6-0.1-0.10.10.91.7-1.1-1.0-1.0-0.9-1.01.3
Rb content in liver1.01.23.11.11.81.01.0-1.0-0.5-1.71.00.80.90.80.9-1.1
Se content in liver1.21.55.3-1.8-2.3-0.4-0.40.40.02.0-1.2-1.0-1.2-1.0-1.00.3
Sr content in liver0.30.30.90.70.30.60.6-0.60.90.0-0.4-0.5-0.4-0.4-0.40.4
Zn content in liver1.82.03.21.61.61.81.8-1.8-0.1-1.51.41.01.21.41.40.9
Bone: minimum diameter1.32.44.81.21.50.30.3-0.3-1.2-1.92.22.22.11.92.00.8
Time in familiar zone, hab. session 10.00.00.10.10.00.10.1-0.10.20.0-0.1-0.00.0-0.1-0.20.2
Time in novel zone, hab. session 10.40.41.2-0.30.3-0.4-0.40.4-1.1-0.60.80.70.60.70.9-0.8
Total zone transitions, hab. session 11.11.52.8-0.8-0.6-1.5-1.51.50.30.8-1.3-1.3-1.4-1.3-1.2-1.7
Total locomotion distance, hab. session 12.84.08.5-2.7-1.9-2.9-2.92.9-2.80.61.21.61.11.11.1-0.1
Locomotion velocity, hab. session 12.43.47.1-2.6-2.0-2.7-2.72.7-2.40.80.91.40.91.00.90.2
Time in familiar zone, hab. session 20.50.51.50.91.20.50.5-0.5-0.2-1.20.70.70.80.70.5-0.5
Time in novel zone, hab. session 20.20.21.30.1-0.30.30.3-0.30.40.4-0.1-0.1-0.1-0.10.11.1
Total zone transitions, hab. session 20.60.72.2-0.20.1-1.2-1.21.20.20.1-0.7-0.9-1.0-0.7-0.7-1.5
Total locomotion distance, hab. session 22.12.86.5-1.7-0.9-2.2-2.22.2-2.5-0.21.51.71.21.51.5-0.4
Locomotion velocity, hab. session 22.43.37.8-1.8-0.8-2.4-2.42.4-2.8-0.41.61.81.41.61.6-0.7
Novel to familiar place preference ratio0.30.31.0-0.6-0.2-1.0-1.01.0-0.10.2-0.2-0.1-0.1-0.5-0.2-0.4
Novelty place preference0.20.20.6-0.30.0-0.8-0.80.8-0.1-0.0-0.10.00.1-0.3-0.1-0.3
Time in novel zone, NPP test0.20.20.6-0.00.3-0.8-0.80.80.0-0.2-0.1-0.00.1-0.3-0.0-0.4
Total zone transitions, NPP test0.40.51.30.50.2-0.3-0.30.31.00.3-0.9-1.2-1.1-0.9-0.7-0.4
Total locomotion distance, NPP test1.41.92.8-1.4-1.3-1.6-1.61.6-1.70.41.21.41.11.31.31.4
Locomotion velocity, NPP test1.52.13.4-1.8-1.6-1.7-1.71.7-1.80.61.21.51.01.31.31.4
Intraocular pressure1.21.75.82.21.71.11.1-1.12.4-0.6-0.8-1.2-0.7-0.9-0.70.4
Delta distance traveled before/after self-admin0.50.51.7-0.8-0.6-0.7-0.70.7-0.20.5-0.7-0.6-0.8-0.6-0.6-1.3
Delta ambulatory time before/after self-admin0.80.93.1-0.7-0.5-0.6-0.60.60.20.6-1.1-1.2-1.2-1.0-1.0-1.8
Parametrial fat weight0.91.75.0-1.5-0.3-1.5-1.51.5-2.2-0.51.01.20.90.90.9-1.6
Pavlov. Cond. lever latency0.60.81.7-1.3-0.9-1.3-1.31.3-0.60.6-0.5-0.3-0.5-0.5-0.3-1.0
Pavlov. Cond. magazine entry latency1.62.04.31.41.52.12.1-2.10.0-1.41.31.21.21.11.20.8
Pavlov. Cond. change in total contacts1.81.95.11.20.72.32.3-2.30.8-0.50.60.60.70.70.52.1
Pavlov. Cond. index score2.02.54.51.91.62.12.1-2.10.1-1.51.41.21.31.31.31.3
Pavlov. Cond. latency score1.51.93.41.61.41.91.9-1.90.2-1.31.21.11.21.11.11.3
Pavlov. Cond. lever contacts1.01.12.01.41.01.31.3-1.30.3-0.90.90.80.90.90.81.2
Pavlov. Cond. magazine entry number2.02.45.2-1.7-1.8-2.3-2.32.3-0.11.6-1.3-1.1-1.1-1.2-1.2-0.7
Pavlov. Cond. intertrial magazine entries0.30.41.2-0.9-1.1-0.9-0.90.9-0.50.8-0.2-0.1-0.2-0.0-0.20.2
Pavlov. Cond. lever-magazine prob. diff.1.72.14.71.71.42.22.2-2.20.3-1.21.11.01.11.11.01.2
Pavlov. Cond. response bias1.21.43.21.21.01.81.8-1.8-0.1-1.01.00.90.91.01.00.9
Pavlov. Cond. lever latency6.99.323.2-4.7-4.8-4.1-4.14.1-1.63.6-1.7-0.7-1.3-1.6-1.8-0.4
Pavlov. Cond. magazine entry latency2.73.17.42.72.42.72.7-2.71.8-1.4-0.0-0.7-0.30.20.20.2
Pavlov. Cond. change in total contacts4.25.714.43.63.83.13.1-3.11.1-2.91.40.71.11.41.60.4
Pavlov. Cond. index score5.87.417.24.14.13.83.8-3.81.7-3.01.20.40.91.31.40.6
Pavlov. Cond. latency score5.26.415.64.03.93.63.6-3.61.8-2.71.00.10.61.11.10.4
Pavlov. Cond. lever contacts6.48.722.94.44.83.83.8-3.81.3-3.71.80.81.41.71.9-0.0
Pavlov. Cond. magazine entry number5.76.916.8-4.1-3.6-3.9-3.93.9-2.52.3-0.50.3-0.3-0.7-0.6-1.0
Pavlov. Cond. intertrial magazine entries1.52.05.2-0.6-0.2-0.9-0.90.9-2.3-0.71.92.01.81.71.80.4
Pavlov. Cond. lever-magazine prob. diff.5.57.016.34.04.03.73.7-3.71.6-2.91.30.51.01.41.40.6
Pavlov. Cond. response bias7.19.722.54.74.74.24.2-4.21.7-3.51.70.71.31.71.80.8
Time in closed arm before self-admin0.70.81.9-0.0-0.6-0.2-0.20.21.21.1-1.3-1.4-1.3-1.2-0.90.3
Time in closed arm after self-admin1.11.23.20.6-0.00.50.5-0.51.50.7-1.5-1.8-1.6-1.4-1.1-0.6
Time in open arm before self-admin0.30.31.1-0.8-0.5-0.7-0.70.7-1.10.10.20.30.10.20.3-0.7
Time in open arm after self-admin0.70.72.1-0.20.3-0.2-0.20.2-1.1-0.81.21.41.41.10.80.2
Bone: periosteal estimation1.32.84.62.02.11.31.3-1.3-0.1-2.11.91.82.01.61.61.3
Bone: periosteal perimeter1.11.95.31.72.30.60.6-0.6-0.5-2.21.51.31.61.21.3-0.7
Bone: post-yield work0.20.20.7-0.1-0.2-0.2-0.20.20.50.4-0.6-0.5-0.5-0.8-0.8-0.3
Progressive ratio test 1 active lever presses0.20.20.5-0.4-0.7-0.1-0.10.10.40.7-0.6-0.5-0.5-0.6-0.60.4
Progressive ratio test 1 breakpoint0.30.30.8-0.5-0.90.10.1-0.10.50.9-0.7-0.5-0.5-0.7-0.70.6
Progressive ratio test 1 inactive lever presses0.10.10.60.1-0.1-0.2-0.20.20.20.1-0.00.00.1-0.10.00.8
Progressive ratio test 2 active lever presses1.01.13.01.21.11.01.0-1.00.7-1.00.90.91.10.90.61.7
Progressive ratio test 2 breakpoint0.70.82.60.90.90.70.7-0.70.5-0.80.91.01.10.80.61.6
Progressive ratio test 2 inactive lever presses0.30.31.70.70.60.20.2-0.20.6-0.40.30.40.50.20.31.3
Incentive Sensitization - Responses1.31.32.21.31.50.70.7-0.70.3-1.41.31.31.51.20.91.3
Incentive Sensitization - Breakpoint1.11.11.91.21.40.60.6-0.60.4-1.31.11.21.41.10.71.4
Sum of active levers in priming session hrs 5-60.30.30.6-0.7-0.2-0.8-0.80.8-0.7-0.00.10.30.20.1-0.1-0.7
Progressive ratio0.70.81.71.30.81.11.1-1.11.3-0.1-0.7-1.1-0.8-0.5-0.30.2
Food seeking constrained by brief footshock1.41.73.81.21.50.80.8-0.8-1.1-1.61.71.31.31.61.90.1
Seeking ratio, punishment vs. effort1.31.64.4-0.7-0.1-0.2-0.20.2-1.9-0.81.82.11.81.61.60.6
Retroperitoneal fat weight3.611.931.3-2.50.3-2.8-2.82.8-5.6-2.54.24.94.33.43.1-2.3
Reaction time number correct0.60.91.9-0.6-0.9-0.8-0.80.80.11.0-1.2-1.3-1.4-1.0-0.9-1.0
Reaction time mean minus median0.60.81.60.71.10.10.1-0.1-0.7-1.31.21.01.01.01.1-0.5
Reaction time mean minus median AUC0.20.30.70.60.80.10.1-0.1-0.3-0.80.60.50.50.50.5-0.6
Reaction time num false alarms0.20.30.8-0.6-0.4-0.7-0.70.7-0.90.00.30.50.30.20.1-0.5
Reaction time num false alarms AUC0.00.10.1-0.2-0.4-0.3-0.30.3-0.10.3-0.10.1-0.1-0.2-0.2-0.0
Reaction time trials correct on left0.60.91.9-0.6-0.9-0.8-0.80.80.11.0-1.2-1.3-1.4-1.0-0.9-1.0
Reaction time trials on left0.60.91.9-0.6-0.9-0.8-0.80.80.11.0-1.2-1.3-1.4-1.0-0.9-0.9
Reaction time mean0.20.20.5-0.7-0.3-0.5-0.50.5-0.7-0.00.40.50.30.30.60.1
Reaction time mean AUC0.10.10.5-0.7-0.4-0.5-0.50.5-0.50.20.10.20.00.10.3-0.1
Median of all reaction times0.10.20.8-0.9-0.7-0.4-0.40.4-0.30.5-0.1-0.0-0.2-0.10.20.5
Reaction time omissions0.40.51.30.30.90.20.2-0.2-0.7-1.01.00.80.81.01.1-0.1
Reaction time false alarm rate0.10.10.3-0.1-0.10.00.0-0.0-0.1-0.10.40.60.50.20.10.6
Reaction time premature initiation rate2.63.58.20.11.20.50.5-0.5-2.2-2.02.72.92.62.42.50.3
Reaction time premature initiations1.11.63.5-0.10.70.20.2-0.2-1.7-1.31.81.91.61.61.8-0.0
Std. dev. reaction times0.91.32.60.51.10.30.3-0.3-1.2-1.41.61.51.41.41.6-0.2
Reaction time trials completed0.60.91.9-0.6-0.9-0.8-0.80.80.11.0-1.2-1.3-1.4-1.0-0.9-0.9
Reaction time trials AUC0.40.61.3-0.6-0.7-0.7-0.70.7-0.10.8-1.0-1.1-1.1-0.8-0.6-0.9
Run reversals in cocaine runway, females3.53.46.50.71.70.70.7-0.7-2.1-2.32.62.32.32.42.5-0.6
Run reversals in cocaine runway, males0.50.51.31.01.10.20.2-0.21.1-0.4-0.6-0.9-0.7-0.4-0.6-0.6
Latency to leave start box in cocaine runway0.50.52.3-1.2-1.50.50.5-0.5-0.61.1-0.10.1-0.2-0.00.10.9
Latency to leave start box in cocaine runway, F0.70.73.5-0.7-1.10.70.7-0.7-0.70.60.60.80.50.60.81.9
Latency to leave start box in cocaine runway, M1.01.02.3-1.2-1.5-0.2-0.20.20.31.5-1.3-1.1-1.2-1.1-1.1-0.3
Std. dev. time between licks in bursts1.51.84.10.20.60.10.1-0.1-1.7-1.22.01.91.82.01.90.4
Total sessions with >9 infusions0.70.82.80.90.01.21.2-1.21.30.3-0.3-0.3-0.2-0.3-0.21.7
Short access day 1 total inactive lever presses0.10.10.30.40.30.20.2-0.20.6-0.1-0.1-0.10.1-0.1-0.10.5
Short access day 10 total inactive lever presses1.82.06.4-1.5-0.9-2.5-2.52.5-0.90.5-0.20.1-0.0-0.2-0.5-1.4
Short access day 1 total infusions1.21.34.71.10.51.71.7-1.70.8-0.30.40.30.50.30.52.2
Short access day 10 total infusions1.51.64.51.30.62.02.0-2.00.9-0.40.50.40.60.50.52.1
Short access total infusions0.91.04.80.80.11.51.5-1.50.80.00.20.20.30.20.32.2
Short access day 1 locomotion1.71.84.21.20.32.02.0-2.02.00.5-0.9-1.2-0.9-0.7-0.61.4
Short access day 10 total locomotion0.20.20.80.20.10.90.9-0.90.3-0.10.10.20.4-0.1-0.10.5
Short access total locomotion0.70.72.7-0.4-1.10.90.9-0.90.81.1-0.6-0.3-0.3-0.5-0.61.7
One hour access (0.3 mA shock)1.41.63.51.71.31.31.3-1.30.6-1.11.11.11.21.10.81.9
Compulsive drug intake0.10.10.40.0-0.40.20.2-0.20.10.4-0.1-0.0-0.10.0-0.00.7
One hour access (shock baseline)0.50.61.31.11.00.90.9-0.90.7-0.70.50.50.70.40.30.9
Social response proportion0.60.73.5-1.9-1.5-0.5-0.50.5-1.10.90.10.50.1-0.10.0-0.2
Social responses1.01.34.4-1.2-0.2-0.7-0.70.7-2.1-0.61.21.51.11.11.2-1.1
Social time0.50.73.1-1.8-1.6-0.2-0.20.2-0.81.2-0.5-0.3-0.6-0.3-0.1-0.1
Soleus weight0.82.55.0-0.20.9-0.9-0.90.9-2.2-1.72.12.22.01.91.7-1.0
Bone: stiffness0.10.20.6-0.4-0.10.20.2-0.20.30.1-0.5-0.2-0.3-0.6-0.7-0.5
Tibialis anterior weight0.31.01.9-0.40.6-1.4-1.41.4-1.2-0.90.91.00.90.70.6-1.1
Time to tail flick, vehicle, before self-admin0.20.21.0-0.4-0.1-0.5-0.50.5-1.0-0.20.30.40.20.30.4-0.7
Time to tail flick, vehicle, after self-admin0.91.02.41.51.21.51.5-1.51.0-0.6-0.3-0.8-0.4-0.10.20.0
Time to tail flick, test, before self-admin0.50.51.11.01.01.01.0-1.00.3-0.70.30.20.30.40.30.2
Time to tail flick, test, after self-admin1.71.82.81.71.61.71.7-1.7-0.2-1.51.20.90.91.31.40.6
Delta time to tail flick, vehicle, before/after SA1.41.43.71.50.81.51.5-1.51.90.1-0.9-1.4-0.9-0.6-0.50.8
Delta time to tail flick, test, before/after SA0.00.00.1-0.3-0.3-0.2-0.20.2-0.30.2-0.0-0.1-0.20.10.2-0.1
Tibia length0.20.62.31.30.50.50.5-0.51.50.1-0.6-0.7-0.5-0.6-0.41.3
Ambulatory time before self-admin0.10.10.3-0.1-0.2-0.1-0.10.10.40.3-0.4-0.4-0.4-0.4-0.5-0.2
Ambulatory time after self-admin1.61.72.6-1.2-1.1-1.1-1.11.10.51.3-1.6-1.6-1.5-1.5-1.6-1.5
Bone: tissue strength3.43.36.1-1.9-2.0-1.5-1.51.50.92.1-2.2-1.7-1.8-2.3-2.5-1.0
Total heroin consumption0.10.10.50.00.3-0.1-0.10.10.1-0.1-0.2-0.3-0.2-0.2-0.4-0.7
Bone: trabecular number0.60.91.9-0.7-0.9-0.1-0.10.10.71.1-1.3-1.1-1.1-1.3-1.4-0.5
Bone: trabecular spacing0.40.51.91.00.40.80.8-0.80.5-0.20.3-0.00.10.50.61.4
Bone: trabecular thickness0.70.83.70.11.10.10.1-0.1-1.0-1.30.80.80.70.60.5-1.9
Bone: trabecular tissue density1.31.95.8-1.4-0.1-1.5-1.51.5-2.4-0.71.11.20.90.80.9-2.2
Water consumed over 24 hours0.70.81.6-1.3-1.2-0.9-0.90.9-0.50.9-0.7-0.4-0.6-0.9-0.8-1.1
Number of responses in last shaping day1.31.36.2-0.1-0.30.10.1-0.1-0.8-0.21.31.41.41.51.52.5