Hub : Genes

Fosl2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL alternative polyA NM_001013146.2 0.04 0.04 1.6e-04 0.03 0.03 0.03 0.03 3.1e-04 2.6e-04 4.9e-04 8.5e-04
2 PL alternative polyA XM_039111806.2 0.04 0.04 1.7e-04 0.03 0.03 0.03 0.03 2.7e-04 2.3e-04 4.6e-04 7.1e-04
3 PL isoform ratio XM_039111806.2 0.04 0.04 6.7e-05 0.03 0.04 0.03 0.03 1.1e-04 7.1e-05 1.3e-04 2.6e-04
4 BLA alternative polyA XM_039111806.2 0.06 0.06 4.5e-03 0.03 0.03 0.03 0.03 6.8e-03 6.5e-03 6.6e-03 7.2e-03
5 Brain alternative polyA NM_001013146.2 0.04 0.04 1.8e-03 0.02 0.03 0.02 0.02 5.8e-03 2.0e-03 6.6e-03 4.9e-03
6 Brain alternative polyA XM_039111806.2 0.04 0.04 1.6e-03 0.02 0.03 0.02 0.02 5.6e-03 1.9e-03 6.2e-03 4.9e-03
7 NAcc alternative polyA XM_039111806.2 0.02 0.02 1.1e-03 0.02 0.02 0.02 0.02 9.8e-04 9.8e-04 1.6e-03 1.4e-03
8 NAcc alternative polyA NM_001013146.2 0.02 0.02 1.2e-03 0.01 0.02 0.01 0.02 2.3e-03 1.1e-03 1.9e-03 1.6e-03
9 BLA isoform ratio XM_039111806.2 0.09 0.08 5.2e-04 0.04 0.05 0.03 0.04 2.1e-03 1.7e-03 9.0e-03 2.0e-03
10 BLA isoform ratio NM_012954.2 0.09 0.07 5.7e-04 0.05 0.05 0.05 0.05 1.7e-03 9.6e-04 1.9e-03 1.2e-03
11 NAcc isoform ratio XM_039111806.2 0.04 0.03 5.0e-06 0.02 0.04 0.03 0.03 1.2e-04 3.7e-06 5.3e-05 4.6e-05
12 NAcc isoform ratio NM_012954.2 0.01 0.02 7.7e-03 0 0.01 0 0 7.3e-02 7.9e-03 4.5e-02 5.5e-02
13 BLA alternative polyA NM_001013146.2 0.06 0.06 3.9e-03 0.04 0.04 0.04 0.04 5.0e-03 4.8e-03 4.4e-03 5.6e-03
14 PL isoform ratio NM_012954.2 0.05 0.05 5.4e-05 0.03 0.03 0.04 0.03 1.1e-04 1.7e-04 6.2e-05 2.5e-04
15 Liver gene expression Fosl2 0.04 0.04 6.5e-04 0.02 0.02 0.02 0.02 2.2e-03 1.7e-03 1.3e-03 3.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density4.68.411.02.9-2.9-2.9-2.92.9-2.92.92.9-2.92.9-2.92.9-2.7-2.93.3
Area under the delay curve1.01.51.81.3-1.3-1.3-1.31.2-1.21.11.3-1.31.3-1.31.3-0.8-1.31.0
BMI with tail0.20.60.9-0.70.70.70.7-0.80.8-0.9-0.80.7-0.70.8-0.80.70.5-0.8
BMI without tail0.31.82.3-1.31.31.31.3-1.41.4-1.5-1.41.4-1.41.4-1.41.20.9-1.4
Body weight1.77.37.9-2.72.72.72.7-2.72.7-2.8-2.72.7-2.72.7-2.72.82.6-2.5
Weight adjusted by age0.00.10.1-0.20.20.20.3-0.20.2-0.3-0.20.3-0.30.2-0.20.20.20.2
Bone surface2.24.36.92.0-2.0-2.0-2.02.1-2.12.12.1-2.02.0-2.12.1-1.8-1.92.6
Bone volume2.34.67.72.1-2.1-2.1-2.12.1-2.12.12.1-2.12.1-2.12.1-1.9-2.12.8
Breakpoint value in progressive ratio session0.51.02.20.9-0.9-0.9-0.91.0-1.01.30.9-0.90.9-1.00.9-0.7-0.71.5
Number of licking bursts0.10.30.50.5-0.5-0.5-0.50.5-0.50.40.5-0.50.5-0.50.5-0.3-0.40.7
Context. condit. distance diff. score0.00.00.1-0.10.10.00.0-0.00.0-0.0-0.00.0-0.00.0-0.00.10.3-0.2
Locomotion velocity, session 10.10.10.4-0.30.30.40.4-0.30.3-0.3-0.40.4-0.40.4-0.40.40.1-0.6
Locomotion distance, session 12.02.53.21.6-1.6-1.6-1.61.6-1.61.61.6-1.61.6-1.61.6-1.7-1.81.2
Locomotion velocity, session 20.10.20.6-0.40.40.40.4-0.40.4-0.3-0.40.4-0.40.4-0.40.20.4-0.8
Locomotion distance, session 20.00.00.4-0.10.10.10.1-0.10.1-0.0-0.10.1-0.10.1-0.1-0.1-0.1-0.7
Locomotion velocity, session 30.40.40.50.7-0.7-0.7-0.70.7-0.70.70.7-0.70.7-0.70.7-0.5-0.50.6
Locomotion distance, session 30.70.81.10.9-0.9-0.9-0.90.9-0.90.90.9-0.90.9-0.90.9-1.0-1.10.8
Stereotopy head waving bouts, day 31.31.61.91.2-1.2-1.2-1.31.3-1.31.41.3-1.31.3-1.31.3-1.2-0.81.3
Stereotopy head waving duration, day 30.00.00.20.2-0.2-0.2-0.20.2-0.20.30.2-0.20.2-0.20.2-0.00.20.4
Locomotion velocity, session 70.70.82.00.9-0.9-0.9-0.90.9-0.90.90.9-0.90.9-0.90.9-0.5-0.81.4
Locomotion distance, session 70.10.10.4-0.10.10.10.1-0.10.1-0.1-0.10.1-0.10.1-0.10.50.50.6
Stereotopy head waving bouts, day 70.00.00.10.2-0.2-0.2-0.20.2-0.20.20.2-0.20.2-0.20.2-0.4-0.2-0.2
Stereotopy head waving duration, day 70.30.40.90.6-0.6-0.6-0.60.6-0.60.60.6-0.60.6-0.60.6-0.9-0.80.0
Locomotion velocity, session 80.00.00.0-0.10.10.10.1-0.10.10.0-0.10.1-0.10.1-0.10.10.2-0.2
Locomotion distance, session 80.20.30.40.6-0.6-0.6-0.60.6-0.60.60.6-0.60.6-0.60.6-0.6-0.50.2
Degree of sensitization distance1.01.12.0-1.11.11.11.1-1.01.0-1.0-1.01.0-1.01.0-1.01.41.4-0.4
Degree of sensitization stereotypy0.10.10.5-0.20.20.20.2-0.20.2-0.3-0.30.3-0.30.3-0.3-0.10.0-0.7
Conditioned locomotion3.13.63.81.9-1.9-1.9-1.91.9-1.91.91.9-1.91.9-2.02.0-1.9-1.51.8
Cocaine response after cond. corrected1.21.82.31.4-1.4-1.4-1.41.4-1.41.21.3-1.41.4-1.31.3-1.4-1.51.1
Cocaine response after cond. not corrected2.33.33.81.9-1.9-1.9-1.81.8-1.81.71.8-1.81.8-1.81.8-1.9-1.91.7
Cocaine response before conditioning0.91.11.21.0-1.0-1.0-1.01.0-1.01.11.0-1.01.0-1.01.0-1.0-1.11.1
Saline control response0.40.51.10.7-0.7-0.7-0.70.7-0.70.70.7-0.70.7-0.70.7-0.9-1.10.5
Bone: connectivity density4.67.49.12.7-2.7-2.7-2.72.7-2.72.82.7-2.72.7-2.72.7-2.6-2.73.0
Bone: cortical apparent density0.71.11.41.0-1.0-1.1-1.11.1-1.11.01.1-1.11.1-1.11.1-1.0-1.01.2
Bone: cortical area0.81.33.61.1-1.1-1.1-1.11.1-1.11.01.1-1.11.1-1.11.1-0.9-1.31.9
Bone: cortical porosity0.80.91.31.0-1.0-1.0-1.01.0-1.00.91.0-1.01.0-1.01.0-1.2-1.00.3
Bone: cortical porosity0.91.01.31.0-1.0-1.0-1.01.0-1.00.91.0-1.01.0-1.01.0-1.1-1.10.5
Bone: cortical thickness0.00.10.30.2-0.2-0.2-0.20.2-0.20.20.2-0.20.2-0.10.1-0.1-0.50.5
Bone: cortical thickness1.61.92.41.4-1.4-1.4-1.41.4-1.41.41.4-1.41.4-1.41.4-1.3-1.51.3
Bone: cortical tissue density0.50.81.00.9-0.9-0.9-0.90.9-0.90.80.9-0.90.9-0.90.9-0.8-0.81.0
Condit. Reinf. active minus inactive responses0.30.40.7-0.60.60.60.6-0.60.6-0.6-0.60.6-0.60.6-0.60.80.7-0.0
Condit. Reinf. active-inactive response ratio0.30.40.6-0.60.60.60.6-0.60.6-0.7-0.60.6-0.60.6-0.60.80.6-0.0
Condit. Reinf. active responses0.40.51.20.7-0.7-0.7-0.70.7-0.70.70.7-0.70.7-0.70.7-0.5-0.61.1
Condit. Reinf. inactive responses1.72.22.51.5-1.5-1.5-1.51.5-1.51.61.5-1.51.5-1.51.5-1.4-1.51.4
Incentive salience index mean0.10.20.90.3-0.3-0.3-0.30.3-0.30.40.3-0.30.3-0.30.3-0.1-0.30.9
Condit. Reinf. lever presses1.01.52.11.2-1.2-1.2-1.21.2-1.21.21.2-1.21.2-1.21.2-1.0-1.21.4
Condit. Reinf. active minus inactive responses3.04.65.42.2-2.2-2.2-2.22.2-2.22.32.2-2.22.2-2.22.2-2.2-1.92.0
Condit. Reinf. active-inactive response ratio0.61.01.31.0-1.0-1.0-1.01.0-1.01.11.0-1.01.0-1.11.1-1.1-0.70.8
Condit. Reinf. active responses3.04.35.72.1-2.1-2.1-2.02.1-2.12.22.1-2.12.1-2.12.1-1.9-1.82.4
Condit. Reinf. inactive responses1.62.45.21.5-1.5-1.5-1.51.5-1.51.51.5-1.51.5-1.51.5-1.1-1.52.3
Condit. Reinf. lever presses2.02.93.51.7-1.7-1.7-1.71.7-1.71.91.7-1.71.7-1.71.7-1.6-1.51.8
Condit. Reinf. lever reinforcers received2.63.75.01.9-1.9-1.9-1.91.9-1.92.11.9-1.91.9-1.91.9-1.8-1.72.2
Conditioned reinforcement - actives0.10.20.60.5-0.5-0.5-0.50.4-0.40.40.4-0.50.5-0.40.5-0.8-0.40.1
Conditioned reinforcement - inactives1.02.73.01.7-1.7-1.6-1.61.7-1.71.71.7-1.61.6-1.71.6-1.7-1.71.5
Conditioned locomotion0.50.81.0-0.80.80.80.8-0.90.9-1.0-0.90.8-0.80.9-0.91.00.7-0.9
Patch foraging indifference point 0 sec0.20.61.2-0.80.80.80.8-0.80.8-0.9-0.80.8-0.80.8-0.81.10.60.1
Patch foraging indifference point AUC0.51.11.61.0-1.0-1.0-1.01.1-1.11.11.0-1.01.0-1.01.0-1.1-1.30.7
Delay disc. indifference point, 0s delay0.91.02.6-0.90.90.90.9-1.01.0-1.2-1.00.9-0.91.0-1.01.00.8-1.6
Delay disc. indifference point, 16s delay0.91.31.51.2-1.2-1.2-1.21.1-1.11.11.2-1.21.2-1.11.1-0.8-1.21.2
Delay disc. indifference point, 2s delay0.10.10.5-0.20.20.20.2-0.20.2-0.2-0.20.1-0.20.2-0.20.40.1-0.7
Delay disc. indifference point, 24s delay3.55.65.92.4-2.4-2.4-2.42.4-2.42.32.4-2.42.4-2.42.4-2.1-2.32.3
Delay disc. indifference point, 4s delay0.10.10.10.3-0.3-0.3-0.30.3-0.30.30.3-0.30.3-0.30.3-0.0-0.20.2
Delay disc. indifference point, 8s delay0.71.11.51.1-1.1-1.1-1.11.1-1.10.91.1-1.11.1-1.11.1-0.7-1.20.8
Indifference point function ln k0.00.00.00.0-0.0-0.0-0.0-0.00.0-0.0-0.0-0.00.00.00.0-0.00.1-0.2
Indifference point function log k0.00.00.00.0-0.0-0.0-0.0-0.00.0-0.0-0.0-0.00.00.00.0-0.00.1-0.2
Patch foraging total patch changes 0 sec0.20.51.1-0.70.70.70.7-0.70.7-0.8-0.70.7-0.70.7-0.71.00.50.1
Patch foraging total patch changes 12 sec1.01.31.8-1.21.21.21.2-1.11.1-1.3-1.21.2-1.21.2-1.21.30.9-0.7
Patch foraging total patch changes 18 sec0.10.30.4-0.50.50.50.5-0.50.5-0.6-0.50.5-0.50.5-0.50.60.3-0.3
Patch foraging total patch changes 24 sec0.72.32.9-1.51.51.51.5-1.51.5-1.6-1.51.5-1.51.5-1.51.71.5-1.2
Patch foraging total patch changes 6 sec0.10.20.2-0.40.40.40.4-0.40.4-0.5-0.40.4-0.40.4-0.40.4-0.0-0.1
Patch foraging time to switch 0 sec0.00.10.50.4-0.4-0.4-0.40.3-0.30.20.3-0.40.4-0.30.3-0.2-0.40.7
Patch foraging water rate 0 sec0.00.10.4-0.40.40.40.4-0.30.3-0.3-0.40.4-0.40.3-0.30.20.4-0.7
Patch foraging water rate 12 sec0.52.22.7-1.51.51.51.5-1.51.5-1.5-1.51.5-1.51.5-1.51.21.5-1.7
Patch foraging water rate 18 sec0.30.71.2-0.80.80.80.7-0.80.8-1.0-0.80.7-0.70.8-0.80.60.8-1.1
Patch foraging water rate 24 sec1.92.82.9-1.71.71.71.7-1.71.7-1.6-1.71.7-1.71.7-1.71.71.7-1.3
Patch foraging water rate 6 sec1.31.92.2-1.41.41.41.4-1.41.4-1.4-1.41.4-1.41.4-1.41.21.5-1.5
Seeking ratio, delayed vs. immediate footshock0.50.72.7-0.80.80.80.8-0.80.8-0.9-0.80.8-0.80.8-0.80.60.6-1.6
Distance traveled before self-admin0.00.00.10.2-0.2-0.2-0.20.2-0.2-0.00.2-0.20.2-0.20.2-0.3-0.00.1
Distance traveled after self-admin1.01.82.1-1.41.41.41.4-1.41.4-1.4-1.41.4-1.41.4-1.41.21.2-1.2
Extensor digitorum longus weight4.718.819.94.3-4.3-4.3-4.34.3-4.34.34.3-4.34.3-4.34.3-4.3-4.54.3
Bone: elastic displacement0.81.01.41.0-1.0-1.0-1.01.0-1.00.91.0-1.01.0-1.01.0-1.2-1.10.5
Bone: elastic work1.21.62.01.2-1.2-1.2-1.21.2-1.21.21.2-1.21.2-1.21.2-1.3-1.31.4
Bone: endosteal estimation0.51.33.51.1-1.1-1.1-1.11.1-1.11.11.1-1.11.1-1.11.1-0.8-0.81.9
Bone: endosteal perimeter0.30.62.40.7-0.7-0.7-0.70.8-0.80.80.8-0.70.7-0.80.8-0.5-0.51.5
Epididymis fat weight10.754.257.7-7.47.47.47.4-7.47.4-7.3-7.47.4-7.47.4-7.47.67.3-6.4
Delta time in closed arm before/after self-admin0.00.00.20.1-0.1-0.1-0.10.1-0.10.20.1-0.10.1-0.10.1-0.1-0.10.5
Delta time in open arm before/after self-admin0.20.20.60.5-0.5-0.5-0.50.5-0.50.30.5-0.50.5-0.40.4-0.4-0.80.5
Diff in mean of infusions in LGA sessions0.00.00.0-0.10.10.10.1-0.10.10.1-0.10.1-0.10.1-0.10.20.10.1
Delay discount exponential model param1.72.42.7-1.61.61.61.6-1.51.5-1.4-1.61.6-1.61.6-1.61.11.6-1.3
Extinction: sum of active levers before priming0.60.91.01.0-1.0-1.0-1.01.0-1.01.01.0-1.01.0-1.01.0-1.0-1.00.6
Active lever presses in extinction session 60.00.00.20.1-0.1-0.1-0.10.1-0.10.20.1-0.10.1-0.10.10.1-0.00.4
Bone: final force0.10.21.40.4-0.4-0.4-0.40.4-0.40.30.4-0.40.4-0.40.4-0.1-0.61.2
Bone: final moment0.20.31.80.5-0.5-0.5-0.50.5-0.50.40.5-0.50.5-0.50.5-0.1-0.61.3
Food consumed during 24 hour testing period0.10.20.20.4-0.4-0.4-0.40.4-0.40.40.4-0.40.4-0.40.4-0.3-0.50.4
Glucose0.50.81.1-0.90.90.90.9-0.90.9-0.9-0.90.9-0.90.9-0.91.01.1-0.6
Heart weight3.04.85.0-2.22.22.22.2-2.22.2-2.2-2.22.2-2.22.2-2.22.12.1-2.0
Delay discount hyperbolic model param1.21.51.8-1.31.31.31.3-1.31.3-1.2-1.31.3-1.31.3-1.30.71.3-1.0
Intermittent access intake day 1-15 change0.00.10.2-0.40.40.40.4-0.40.4-0.3-0.40.4-0.40.4-0.40.40.5-0.4
Intermittent access intake escalation0.10.30.4-0.50.60.50.5-0.60.6-0.5-0.60.5-0.50.6-0.50.60.7-0.6
Intermittent access intake escalation 20.20.40.6-0.60.60.60.6-0.70.7-0.5-0.60.6-0.60.6-0.60.80.6-0.8
Intermitt. access day 1 inactive lever presses0.00.50.70.7-0.7-0.7-0.70.7-0.70.80.7-0.70.7-0.70.7-0.7-0.70.8
Intermitt. access day 15 inactive lever presses0.63.13.61.8-1.8-1.8-1.71.8-1.81.91.8-1.71.7-1.71.7-1.9-1.91.5
Intermitt. access escalation Index0.20.81.0-0.90.90.90.9-0.90.9-0.8-0.91.0-1.00.9-0.91.00.7-0.5
Intermittent access day 1 total infusions1.23.54.11.9-1.9-1.9-1.91.9-1.92.01.9-1.81.8-1.91.9-1.9-2.01.7
Intermittent access day 15 total infusions0.30.81.00.9-0.9-0.9-0.90.9-0.91.00.9-0.90.9-0.90.9-0.9-1.00.8
Intermittent access terminal intake (last 3 days)0.81.41.51.2-1.2-1.2-1.21.2-1.21.21.2-1.21.2-1.21.2-1.2-1.21.1
Intermittent access total infusions1.21.51.71.2-1.2-1.2-1.21.2-1.21.21.2-1.21.2-1.21.2-1.3-1.21.0
Intermittent access day 1 locomotion1.12.12.71.4-1.4-1.4-1.41.5-1.51.41.4-1.41.4-1.41.4-1.3-1.71.5
Intermittent access day 15 total locomotion0.00.00.00.1-0.1-0.1-0.10.1-0.10.10.1-0.10.1-0.10.1-0.1-0.1-0.2
Intermittent access total locomotion0.00.00.10.2-0.2-0.2-0.20.2-0.20.10.2-0.20.2-0.20.2-0.2-0.3-0.1
Intermittent access standard deviation0.10.60.80.8-0.8-0.8-0.80.8-0.80.90.8-0.80.8-0.80.8-0.7-0.80.7
Left kidney weight0.00.00.00.1-0.1-0.1-0.10.0-0.0-0.00.0-0.10.1-0.00.0-0.1-0.0-0.1
Right kidney weight0.00.30.6-0.50.50.50.5-0.60.6-0.7-0.60.5-0.50.6-0.60.50.4-0.8
Cocaine induced anxiety0.00.10.30.2-0.2-0.2-0.20.2-0.20.30.2-0.20.2-0.20.2-0.1-0.30.5
Post-drug Anxiety1.21.41.7-1.21.21.21.2-1.21.2-1.1-1.21.2-1.21.2-1.21.21.3-0.7
Baseline Anxiety1.62.62.9-1.61.61.61.6-1.61.6-1.7-1.61.6-1.61.6-1.61.51.7-1.5
Tail length0.42.22.4-1.51.51.51.5-1.51.5-1.4-1.51.5-1.51.5-1.51.51.5-1.3
Length with tail1.88.08.7-2.92.92.92.8-2.92.9-2.8-2.82.8-2.82.8-2.83.02.9-2.4
Length without tail0.41.92.8-1.41.41.41.4-1.41.4-1.3-1.41.4-1.41.3-1.31.61.7-1.1
Times rat made contact with spout2.73.14.01.7-1.7-1.8-1.81.8-1.81.81.8-1.81.8-1.81.8-1.6-1.62.0
Lifetime Intake1.01.21.41.1-1.1-1.1-1.11.1-1.11.21.1-1.11.1-1.11.1-1.1-1.11.0
Liver weight, left3.76.56.8-2.62.62.62.6-2.62.6-2.5-2.62.6-2.62.6-2.62.62.4-2.2
Liver weight, right10.017.518.0-4.24.24.24.2-4.24.2-4.2-4.24.2-4.24.2-4.24.23.9-3.8
Locomotor activity0.00.00.20.1-0.1-0.1-0.10.0-0.0-0.10.0-0.10.1-0.00.00.0-0.40.0
Locomotor testing distance0.41.01.71.0-1.0-1.0-1.01.0-1.00.81.0-1.01.0-1.01.0-0.9-1.30.8
Locomotor testing rearing0.20.81.20.9-0.9-0.9-0.90.9-0.90.90.9-0.80.8-0.90.8-0.6-1.11.1
Locomotion in novel chamber0.60.81.3-0.90.90.90.9-0.90.9-0.9-0.91.0-0.90.9-0.91.10.90.0
Locomotion in novel chamber post-restriction1.13.44.1-1.91.91.81.9-1.81.8-2.0-1.91.9-1.91.8-1.82.01.9-1.4
Fecal boli incidents, locomotor time 10.20.60.90.8-0.8-0.8-0.80.8-0.80.40.8-0.80.8-0.80.8-1.0-0.50.3
Change in fecal boli incidents, locomotor task3.84.04.3-2.02.02.12.1-2.02.0-2.0-2.02.1-2.12.0-2.01.81.9-1.9
Time >=10cm from walls, locomotor time 10.10.10.20.3-0.3-0.3-0.30.3-0.30.40.3-0.30.3-0.30.3-0.5-0.10.0
Bouts of movement, locomotor time 12.83.64.12.0-2.0-2.0-2.01.9-1.91.51.9-2.02.0-1.91.9-1.8-2.01.6
Total resting periods, locomotor time 13.13.64.12.0-2.0-2.0-2.01.9-1.91.51.9-2.02.0-1.92.0-1.8-1.91.7
Rest time, locomotor task time 10.10.10.4-0.30.30.30.3-0.30.3-0.4-0.30.2-0.30.3-0.20.40.6-0.3
Distance moved, locomotor task time 10.30.71.1-0.90.90.90.9-0.90.9-0.7-0.90.9-0.90.9-0.91.00.5-0.5
Vertical activity count, locomotor time 10.00.20.3-0.50.50.50.5-0.50.5-0.3-0.50.5-0.50.5-0.50.50.4-0.3
Time >=10cm from walls, locomotor time 20.00.00.10.1-0.1-0.1-0.10.2-0.20.20.2-0.10.1-0.20.2-0.1-0.00.1
Bouts of movement, locomotor time 20.00.00.1-0.10.10.10.1-0.10.1-0.1-0.10.0-0.00.0-0.0-0.00.3-0.3
Total resting periods, locomotor time 20.00.00.10.1-0.1-0.1-0.10.1-0.10.10.1-0.20.2-0.20.2-0.30.2-0.2
Rest time, locomotor task time 21.11.82.11.4-1.4-1.4-1.41.4-1.41.41.4-1.41.4-1.41.4-1.4-1.01.1
Distance moved, locomotor task time 21.21.52.5-1.31.31.31.3-1.31.3-1.1-1.31.3-1.31.3-1.31.60.8-0.6
Vertical activity count, locomotor time 20.51.21.3-1.11.11.11.1-1.11.1-1.0-1.11.2-1.21.1-1.11.11.0-0.6
Light reinforcement 11.77.711.22.7-2.7-2.7-2.72.7-2.72.62.7-2.72.7-2.72.7-2.5-3.13.3
Light reinforcement 21.94.24.72.1-2.1-2.1-2.12.1-2.12.12.1-2.12.1-2.12.1-1.9-2.02.2
Bone: marrow area0.51.33.51.1-1.1-1.1-1.11.1-1.11.11.1-1.11.1-1.11.1-0.8-0.81.9
Bone: maximum diameter1.32.65.81.6-1.6-1.6-1.61.6-1.61.51.6-1.61.6-1.61.6-1.3-1.62.4
Bone: maximum force0.20.31.60.5-0.5-0.5-0.50.5-0.50.40.5-0.50.5-0.50.5-0.2-0.61.3
Bone: maximum moment0.20.52.10.6-0.6-0.6-0.60.6-0.60.60.6-0.60.6-0.60.6-0.3-0.61.5
Mean time between licks in bursts0.63.64.4-1.91.91.91.9-1.91.9-1.7-1.91.9-1.91.9-1.91.82.1-1.9
Mean num. licks in bursts0.00.10.20.3-0.3-0.3-0.30.3-0.30.40.3-0.30.3-0.30.3-0.4-0.40.4
Cd content in liver0.10.10.20.2-0.2-0.2-0.20.2-0.20.10.2-0.20.2-0.20.2-0.3-0.40.2
Co content in liver7.28.510.52.9-2.9-2.9-2.92.9-2.92.72.9-2.92.9-2.92.9-2.9-3.22.8
Cu content in liver0.10.10.20.4-0.4-0.4-0.40.4-0.40.30.4-0.40.4-0.40.4-0.5-0.50.3
Fe content in liver0.40.50.70.7-0.7-0.7-0.70.7-0.70.70.7-0.70.7-0.70.7-0.6-0.60.8
K content in liver0.30.30.40.5-0.5-0.5-0.50.5-0.50.60.6-0.50.5-0.60.6-0.4-0.10.7
Mg content in liver0.50.50.90.7-0.7-0.7-0.70.7-0.70.80.7-0.70.7-0.70.7-0.6-0.50.9
Mn content in liver0.00.00.00.1-0.1-0.1-0.10.1-0.10.10.1-0.10.1-0.10.1-0.1-0.10.1
Na content in liver0.20.30.40.5-0.5-0.5-0.50.5-0.50.60.5-0.50.5-0.50.5-0.5-0.30.4
Rb content in liver0.00.10.10.2-0.2-0.2-0.20.2-0.20.20.2-0.20.2-0.20.2-0.2-0.20.3
Se content in liver0.40.50.6-0.70.70.70.7-0.70.7-0.7-0.70.7-0.70.7-0.70.80.6-0.5
Sr content in liver0.10.10.3-0.30.30.30.3-0.20.2-0.2-0.20.2-0.20.2-0.20.30.5-0.2
Zn content in liver0.70.81.0-0.90.90.90.9-0.90.9-1.0-1.00.9-0.91.0-1.00.80.6-0.7
Bone: minimum diameter0.10.10.7-0.20.20.20.2-0.20.2-0.4-0.20.2-0.20.2-0.20.50.00.8
Time in familiar zone, hab. session 10.70.80.9-0.90.90.90.9-0.90.9-0.9-0.90.9-0.90.9-0.90.90.8-0.5
Time in novel zone, hab. session 10.60.70.9-0.80.80.80.8-0.80.8-0.8-0.80.9-0.90.8-0.80.80.8-0.9
Total zone transitions, hab. session 10.10.20.30.4-0.4-0.4-0.40.4-0.40.50.4-0.40.4-0.40.4-0.4-0.50.4
Total locomotion distance, hab. session 10.10.10.20.3-0.3-0.3-0.30.3-0.30.30.3-0.30.3-0.30.3-0.3-0.30.5
Locomotion velocity, hab. session 11.01.41.71.2-1.2-1.2-1.21.2-1.21.21.2-1.21.2-1.21.2-1.1-1.11.3
Time in familiar zone, hab. session 20.00.00.1-0.10.10.10.1-0.10.1-0.0-0.10.2-0.20.2-0.20.2-0.1-0.0
Time in novel zone, hab. session 20.20.30.5-0.50.50.50.5-0.50.5-0.6-0.50.5-0.50.5-0.50.50.7-0.4
Total zone transitions, hab. session 20.20.30.40.5-0.5-0.5-0.50.5-0.50.50.5-0.50.5-0.50.5-0.6-0.60.3
Total locomotion distance, hab. session 20.20.30.50.6-0.6-0.6-0.60.6-0.60.60.6-0.60.6-0.60.6-0.7-0.50.2
Locomotion velocity, hab. session 20.50.71.00.8-0.8-0.8-0.80.8-0.80.80.8-0.80.8-0.80.8-1.0-0.70.5
Novel to familiar place preference ratio0.30.40.8-0.70.70.70.6-0.70.7-0.8-0.70.6-0.60.7-0.70.30.6-0.9
Novelty place preference0.70.91.4-1.01.01.00.9-1.01.0-1.1-1.00.9-0.91.0-1.00.60.9-1.2
Time in novel zone, NPP test1.01.21.6-1.11.11.11.1-1.11.1-1.2-1.11.1-1.11.1-1.10.81.0-1.3
Total zone transitions, NPP test1.52.22.71.5-1.5-1.5-1.51.5-1.51.51.5-1.51.5-1.51.5-1.6-1.61.0
Total locomotion distance, NPP test1.82.62.91.6-1.6-1.6-1.61.6-1.61.71.6-1.61.6-1.61.6-1.7-1.61.3
Locomotion velocity, NPP test3.44.95.52.2-2.2-2.2-2.22.2-2.22.32.2-2.22.2-2.22.2-2.4-2.21.8
Intraocular pressure2.94.85.5-2.22.22.22.2-2.22.2-2.3-2.22.2-2.22.2-2.22.22.1-2.0
Delta distance traveled before/after self-admin2.52.72.9-1.71.71.71.7-1.71.7-1.6-1.71.7-1.71.7-1.71.71.5-1.3
Delta ambulatory time before/after self-admin0.20.40.9-0.60.60.70.6-0.60.6-0.6-0.60.7-0.70.7-0.70.90.5-0.4
Parametrial fat weight10.524.827.3-5.05.05.05.0-5.05.0-5.1-5.05.0-5.05.0-5.05.24.6-4.4
Pavlov. Cond. lever latency1.72.22.6-1.51.51.51.5-1.51.5-1.5-1.51.5-1.51.5-1.51.31.4-1.6
Pavlov. Cond. magazine entry latency0.10.10.10.3-0.3-0.3-0.30.3-0.30.30.3-0.30.3-0.30.3-0.3-0.20.1
Pavlov. Cond. change in total contacts0.00.00.10.2-0.2-0.2-0.20.2-0.20.20.2-0.20.2-0.20.2-0.1-0.10.2
Pavlov. Cond. index score0.70.91.00.9-0.9-0.9-0.91.0-1.01.01.0-1.01.0-1.01.0-0.8-0.81.0
Pavlov. Cond. latency score0.60.80.90.9-0.9-0.9-0.90.9-0.90.90.9-0.90.9-0.90.9-0.8-0.71.0
Pavlov. Cond. lever contacts1.21.41.61.2-1.2-1.2-1.21.2-1.21.21.2-1.21.2-1.21.2-1.0-1.01.3
Pavlov. Cond. magazine entry number0.30.40.5-0.70.70.70.7-0.70.7-0.7-0.70.7-0.70.7-0.70.60.5-0.7
Pavlov. Cond. intertrial magazine entries1.61.93.01.4-1.4-1.4-1.41.4-1.41.41.4-1.41.4-1.41.4-1.1-1.41.7
Pavlov. Cond. lever-magazine prob. diff.1.51.92.11.4-1.4-1.4-1.41.4-1.41.41.4-1.41.4-1.41.4-1.3-1.21.3
Pavlov. Cond. response bias1.21.51.71.2-1.2-1.2-1.21.2-1.21.31.3-1.21.2-1.31.3-1.1-1.01.2
Pavlov. Cond. lever latency1.42.02.3-1.41.41.41.4-1.41.4-1.5-1.41.4-1.41.4-1.41.41.2-1.5
Pavlov. Cond. magazine entry latency0.00.10.20.2-0.2-0.2-0.20.2-0.20.20.2-0.20.2-0.20.2-0.2-0.20.4
Pavlov. Cond. change in total contacts0.41.11.41.0-1.0-1.0-1.01.0-1.01.21.0-1.01.0-1.11.1-1.2-0.80.9
Pavlov. Cond. index score0.71.11.41.1-1.1-1.1-1.11.1-1.11.11.1-1.11.1-1.11.1-1.0-0.81.2
Pavlov. Cond. latency score0.61.01.11.0-1.0-1.0-1.01.0-1.01.11.0-1.01.0-1.01.0-1.0-0.71.0
Pavlov. Cond. lever contacts1.01.51.91.2-1.2-1.2-1.21.2-1.21.31.2-1.21.2-1.21.2-1.2-1.01.4
Pavlov. Cond. magazine entry number0.10.10.3-0.30.30.30.3-0.30.3-0.3-0.30.3-0.30.3-0.30.20.2-0.6
Pavlov. Cond. intertrial magazine entries1.83.94.3-2.02.02.02.0-2.02.0-2.0-2.02.0-2.02.0-2.02.11.8-1.7
Pavlov. Cond. lever-magazine prob. diff.0.40.60.90.8-0.8-0.8-0.80.8-0.80.90.8-0.80.8-0.80.8-0.8-0.51.0
Pavlov. Cond. response bias1.72.33.11.5-1.5-1.5-1.51.5-1.51.61.5-1.51.5-1.51.5-1.4-1.31.8
Time in closed arm before self-admin0.91.52.0-1.21.21.21.2-1.21.2-1.2-1.21.3-1.31.3-1.31.41.1-1.1
Time in closed arm after self-admin1.71.92.7-1.41.41.41.4-1.41.4-1.3-1.41.4-1.41.4-1.41.61.4-1.1
Time in open arm before self-admin0.30.40.60.6-0.6-0.6-0.60.6-0.60.70.6-0.60.6-0.60.6-0.8-0.40.5
Time in open arm after self-admin1.92.12.21.4-1.4-1.4-1.51.4-1.41.41.5-1.51.5-1.51.5-1.4-1.51.4
Bone: periosteal estimation1.02.46.01.5-1.5-1.5-1.51.5-1.51.41.5-1.51.5-1.51.5-1.2-1.42.5
Bone: periosteal perimeter0.61.13.41.0-1.0-1.0-1.01.0-1.01.01.0-1.01.0-1.01.0-0.7-0.91.8
Bone: post-yield work0.61.11.81.0-1.0-1.0-1.01.0-1.01.11.0-1.01.0-1.01.1-0.8-0.81.3
Progressive ratio test 1 active lever presses0.50.91.01.0-1.0-1.0-1.01.0-1.01.01.0-1.01.0-1.01.0-1.0-0.91.0
Progressive ratio test 1 breakpoint0.61.11.11.0-1.0-1.0-1.01.0-1.01.01.0-1.01.0-1.01.0-1.0-0.91.1
Progressive ratio test 1 inactive lever presses0.51.42.31.1-1.1-1.1-1.11.2-1.21.21.2-1.11.1-1.21.1-1.5-1.30.6
Progressive ratio test 2 active lever presses0.00.00.00.0-0.0-0.0-0.0-0.00.0-0.00.0-0.00.0-0.00.00.10.20.2
Progressive ratio test 2 breakpoint0.00.00.1-0.10.10.00.0-0.10.1-0.1-0.10.0-0.00.1-0.00.20.30.1
Progressive ratio test 2 inactive lever presses0.00.10.20.4-0.4-0.4-0.40.4-0.40.50.4-0.40.4-0.40.4-0.3-0.30.5
Incentive Sensitization - Responses0.00.00.10.0-0.0-0.0-0.0-0.10.1-0.0-0.0-0.00.00.00.00.20.10.4
Incentive Sensitization - Breakpoint0.00.00.1-0.20.20.20.2-0.20.3-0.2-0.20.1-0.10.2-0.20.30.30.1
Sum of active levers in priming session hrs 5-61.21.21.31.1-1.1-1.1-1.11.1-1.11.11.1-1.11.1-1.11.1-1.1-1.01.1
Progressive ratio0.41.11.8-1.11.11.11.1-1.01.0-0.5-1.01.1-1.11.0-1.01.11.3-0.7
Food seeking constrained by brief footshock1.51.82.91.4-1.4-1.4-1.41.3-1.31.51.4-1.41.4-1.41.4-1.7-1.40.4
Seeking ratio, punishment vs. effort0.71.52.21.3-1.3-1.3-1.31.2-1.20.91.2-1.31.3-1.21.2-1.5-1.50.6
Retroperitoneal fat weight20.893.2100.5-9.89.89.89.7-9.79.7-9.7-9.79.7-9.79.7-9.710.09.3-8.5
Reaction time number correct0.31.11.31.1-1.1-1.1-1.11.0-1.00.91.0-1.11.1-1.01.1-1.1-0.90.8
Reaction time mean minus median0.00.00.4-0.00.00.00.0-0.10.1-0.3-0.10.0-0.00.1-0.1-0.3-0.4-0.6
Reaction time mean minus median AUC0.00.10.6-0.20.20.20.2-0.20.2-0.4-0.20.2-0.20.2-0.2-0.1-0.2-0.8
Reaction time num false alarms0.20.30.80.6-0.6-0.6-0.60.5-0.50.50.5-0.60.6-0.50.5-0.5-0.60.9
Reaction time num false alarms AUC0.30.61.30.8-0.8-0.8-0.80.7-0.70.70.7-0.80.8-0.70.7-0.6-0.91.1
Reaction time trials correct on left0.31.11.31.1-1.1-1.1-1.11.0-1.00.91.0-1.11.1-1.01.1-1.1-0.90.8
Reaction time trials on left0.31.11.41.1-1.1-1.1-1.11.1-1.11.01.1-1.11.1-1.11.1-1.2-1.00.8
Reaction time mean0.71.51.7-1.21.21.31.3-1.31.3-1.3-1.31.3-1.31.3-1.31.10.9-1.2
Reaction time mean AUC0.51.31.4-1.11.11.11.1-1.21.2-1.2-1.21.1-1.21.2-1.21.00.8-1.1
Median of all reaction times1.11.71.8-1.31.31.31.3-1.31.3-1.3-1.31.3-1.31.3-1.41.31.1-1.1
Reaction time omissions0.00.10.10.2-0.2-0.2-0.20.2-0.20.10.2-0.20.2-0.20.2-0.2-0.40.3
Reaction time false alarm rate0.00.00.40.1-0.1-0.1-0.10.1-0.10.20.1-0.10.1-0.10.10.1-0.20.7
Reaction time premature initiation rate0.10.21.1-0.40.40.40.4-0.40.4-0.4-0.40.4-0.40.3-0.30.10.5-1.1
Reaction time premature initiations0.00.10.40.2-0.2-0.2-0.20.2-0.20.10.3-0.30.3-0.30.3-0.5-0.1-0.6
Std. dev. reaction times0.20.60.8-0.70.70.70.7-0.80.8-0.8-0.80.8-0.80.8-0.80.60.4-0.9
Reaction time trials completed0.31.11.41.1-1.1-1.1-1.11.1-1.11.01.1-1.11.1-1.11.1-1.2-1.00.8
Reaction time trials AUC0.41.41.61.2-1.2-1.2-1.21.2-1.21.11.2-1.21.2-1.21.2-1.3-1.11.0
Run reversals in cocaine runway, females0.00.00.20.1-0.1-0.1-0.10.1-0.10.10.1-0.10.1-0.10.1-0.40.1-0.4
Run reversals in cocaine runway, males0.50.61.40.8-0.8-0.8-0.80.7-0.70.60.7-0.70.7-0.70.7-1.2-0.80.3
Latency to leave start box in cocaine runway0.20.30.40.5-0.5-0.5-0.50.5-0.50.40.5-0.50.5-0.50.5-0.5-0.60.2
Latency to leave start box in cocaine runway, F0.30.40.80.6-0.6-0.6-0.60.6-0.60.50.6-0.60.6-0.60.6-0.5-0.60.9
Latency to leave start box in cocaine runway, M0.30.32.1-0.40.40.40.4-0.40.4-0.5-0.40.4-0.40.4-0.40.10.2-1.4
Std. dev. time between licks in bursts0.00.10.1-0.30.30.30.3-0.30.3-0.1-0.30.3-0.30.3-0.30.40.2-0.1
Total sessions with >9 infusions0.00.00.10.1-0.1-0.1-0.10.2-0.20.30.2-0.10.1-0.20.1-0.2-0.20.2
Short access day 1 total inactive lever presses3.06.08.02.5-2.5-2.4-2.42.5-2.52.52.5-2.42.4-2.52.4-2.8-2.51.7
Short access day 10 total inactive lever presses0.53.23.81.8-1.8-1.8-1.81.9-1.92.01.8-1.81.8-1.81.8-1.9-1.81.4
Short access day 1 total infusions0.51.01.51.0-1.0-1.0-0.91.0-1.11.21.0-0.90.9-1.01.0-1.1-1.11.0
Short access day 10 total infusions1.11.72.31.3-1.3-1.3-1.31.3-1.31.31.3-1.31.3-1.31.3-1.5-1.21.1
Short access total infusions0.10.10.20.3-0.3-0.3-0.30.4-0.40.50.3-0.30.3-0.30.3-0.3-0.30.3
Short access day 1 locomotion0.71.21.61.1-1.1-1.1-1.11.1-1.11.21.1-1.11.1-1.11.1-1.3-1.20.7
Short access day 10 total locomotion0.51.82.51.4-1.4-1.4-1.41.3-1.31.21.3-1.41.4-1.31.3-1.5-1.61.0
Short access total locomotion0.00.00.00.0-0.0-0.0-0.00.0-0.0-0.00.00.0-0.0-0.0-0.0-0.0-0.2-0.1
One hour access (0.3 mA shock)0.20.30.40.5-0.5-0.5-0.50.5-0.50.70.5-0.60.6-0.60.6-0.4-0.40.4
Compulsive drug intake0.10.10.3-0.40.40.40.4-0.30.3-0.1-0.30.4-0.40.3-0.40.20.5-0.5
One hour access (shock baseline)0.41.01.11.0-1.0-1.0-1.01.0-1.00.91.0-1.01.0-1.01.0-0.9-1.00.9
Social response proportion0.60.70.8-0.90.90.90.9-0.90.9-0.9-0.90.9-0.90.9-0.90.90.5-0.6
Social responses0.20.20.5-0.50.50.50.5-0.50.5-0.7-0.50.5-0.50.5-0.50.50.0-0.2
Social time1.11.82.4-1.31.31.31.3-1.41.4-1.4-1.41.3-1.31.4-1.41.10.8-1.5
Soleus weight5.817.118.94.2-4.2-4.2-4.24.2-4.24.14.2-4.24.2-4.14.1-4.2-4.33.6
Bone: stiffness0.00.00.60.1-0.1-0.1-0.10.1-0.10.10.1-0.10.1-0.10.10.1-0.10.7
Tibialis anterior weight4.314.717.43.9-3.9-3.9-3.93.8-3.83.83.8-3.83.8-3.83.8-3.6-4.23.8
Time to tail flick, vehicle, before self-admin1.11.41.9-1.21.21.21.1-1.21.2-1.4-1.21.1-1.11.2-1.20.91.1-1.4
Time to tail flick, vehicle, after self-admin1.93.95.1-2.02.02.01.9-2.02.0-2.3-2.01.9-2.02.0-2.01.71.7-2.2
Time to tail flick, test, before self-admin0.10.10.10.2-0.2-0.2-0.20.3-0.30.30.2-0.20.2-0.20.2-0.3-0.30.2
Time to tail flick, test, after self-admin0.10.10.20.3-0.3-0.3-0.40.3-0.30.20.3-0.40.4-0.30.3-0.2-0.20.4
Delta time to tail flick, vehicle, before/after SA0.00.00.1-0.10.10.10.1-0.10.1-0.2-0.10.1-0.10.1-0.10.30.10.1
Delta time to tail flick, test, before/after SA1.31.61.81.3-1.3-1.3-1.31.3-1.31.21.3-1.31.3-1.31.3-1.1-1.11.3
Tibia length3.18.710.1-3.03.03.03.0-3.03.0-2.9-3.03.0-3.03.0-3.03.22.9-2.0
Ambulatory time before self-admin0.00.10.20.3-0.3-0.3-0.30.3-0.30.20.3-0.40.4-0.30.3-0.5-0.20.2
Ambulatory time after self-admin0.71.21.5-1.11.11.11.1-1.11.1-1.2-1.11.1-1.11.1-1.11.00.9-0.9
Bone: tissue strength0.40.40.6-0.70.70.70.7-0.60.6-0.6-0.60.7-0.70.6-0.60.80.7-0.2
Total heroin consumption3.54.15.02.0-2.0-2.0-2.02.1-2.12.22.0-2.02.0-2.02.0-1.8-2.02.2
Bone: trabecular number3.36.27.42.5-2.5-2.5-2.52.5-2.52.52.5-2.52.5-2.52.5-2.4-2.62.7
Bone: trabecular spacing1.92.94.2-1.71.71.71.7-1.71.7-1.8-1.71.7-1.71.7-1.71.51.4-2.1
Bone: trabecular thickness0.60.82.70.8-0.8-0.8-0.80.8-0.80.80.8-0.80.8-0.80.8-0.6-0.91.7
Bone: trabecular tissue density0.10.30.30.5-0.5-0.5-0.50.5-0.50.50.5-0.60.6-0.50.6-0.5-0.30.4
Water consumed over 24 hours0.40.81.90.9-0.9-0.9-0.90.9-0.90.80.9-0.90.9-0.90.9-0.5-0.61.4
Number of responses in last shaping day0.20.20.3-0.50.50.50.5-0.50.5-0.3-0.50.5-0.50.5-0.50.20.6-0.4