Hub : Genes

Atraid

all-trans retinoic acid-induced differentiation factor

chr6:31035194–31039779 (-)

Atraid RatGTEx page

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA mRNA stability Atraid 0.25 0.28 9.8e-04 0.05 0.05 0.03 0.04 1.8e-03 1.9e-03 6.2e-03 3.4e-03
2 Brain mRNA stability Atraid 0.07 0.05 3.8e-08 0.06 0.08 0.06 0.07 3.1e-06 1.1e-07 4.5e-06 7.3e-07
3 IL mRNA stability Atraid 0.23 0.19 5.8e-04 0.16 0.1 0.14 0.13 1.5e-04 2.0e-03 2.9e-04 5.8e-04
4 pVTA intron excision ratio chr6_31037182_31038877 0.13 0.09 2.2e-05 0.05 0.06 0.06 0.06 6.9e-05 6.8e-06 2.2e-05 1.2e-05
5 LHb gene expression Atraid 0.48 0.38 2.8e-05 0.22 0.15 0.17 0.19 7.1e-06 1.8e-04 8.3e-05 2.5e-05
6 Liver gene expression Atraid 0.33 0.19 0.0e+00 0.26 0.26 0.26 0.26 3.2e-28 3.9e-28 3.0e-28 3.0e-28
7 Adipose gene expression Atraid 0.22 0.16 0.0e+00 0.16 0.16 0.16 0.16 5.4e-17 6.1e-18 8.2e-18 6.8e-18
8 PL gene expression Atraid 0.45 0.08 5.6e-17 0.17 0.15 0.16 0.16 7.0e-18 3.6e-16 1.3e-16 3.8e-17
9 Adipose mRNA stability Atraid 0.04 0.04 9.4e-04 0.02 0.02 0.02 0.02 4.4e-03 3.6e-03 3.1e-03 4.8e-03
10 NAcc mRNA stability Atraid 0.04 0.03 2.3e-07 0.04 0.04 0.04 0.04 1.9e-06 3.6e-07 1.1e-06 6.7e-07
11 PL mRNA stability Atraid 0.05 0.05 1.2e-05 0.04 0.05 0.04 0.04 3.0e-05 8.3e-06 1.3e-05 1.3e-05
12 Brain gene expression Atraid 0.52 0.21 0.0e+00 0.22 0.2 0.22 0.21 2.9e-20 4.9e-18 4.1e-20 1.1e-19
13 RMTg gene expression Atraid 0.21 0.12 2.2e-06 0.19 0.2 0.17 0.2 7.3e-06 5.0e-06 2.4e-05 5.3e-06
14 pVTA gene expression Atraid 0.17 0.1 4.1e-13 0.17 0.17 0.15 0.17 1.2e-13 5.7e-14 3.5e-12 7.0e-14
15 OFC mRNA stability Atraid 0.42 0.38 1.4e-04 0.17 0.14 0.14 0.15 8.6e-05 3.7e-04 3.8e-04 2.0e-04
16 NAcc gene expression Atraid 0.21 0.37 5.6e-14 0.1 0.09 0.1 0.1 3.9e-15 3.1e-13 1.7e-14 6.2e-15
17 IC gene expression Atraid 0.28 0.23 4.6e-03 0.03 0.04 0.02 0.02 2.2e-02 1.4e-02 3.7e-02 6.5e-02
18 PL intron excision ratio chr6_31037182_31038552 0.03 0.03 1.8e-03 0.03 0.03 0.03 0.03 1.7e-04 8.7e-04 2.8e-04 2.7e-04
19 BLA gene expression Atraid 0.16 0.16 5.5e-06 0.12 0.09 0.11 0.11 1.0e-06 1.2e-05 1.4e-06 3.0e-06
20 pVTA mRNA stability Atraid 0.17 0.11 1.1e-09 0.12 0.12 0.11 0.12 5.0e-10 4.6e-10 4.6e-09 3.3e-10
21 PL intron excision ratio chr6_31037182_31038877 0.03 0.03 8.0e-04 0.03 0.03 0.03 0.03 1.9e-04 3.6e-04 1.6e-04 2.0e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
Bone: apparent density3.96.79.53.12.81.92.2-1.9-3.0-2.8-2.8-2.82.62.6-2.8-2.9-2.63.1-2.7-2.4-1.9-2.92.31.9
Area under the delay curve0.10.21.20.60.3-0.30.10.2-0.2-0.2-0.4-0.40.20.2-0.2-0.2-0.10.9-0.4-0.00.1-1.10.1-0.2
BMI with tail0.41.33.4-1.0-1.3-1.8-1.61.40.91.11.11.1-1.2-1.11.10.91.1-0.80.91.31.00.9-1.0-0.9
BMI without tail0.82.44.5-1.5-1.6-2.1-1.81.91.41.51.41.5-1.5-1.51.61.41.5-1.51.21.41.41.5-1.4-1.3
Body weight2.410.413.8-3.3-3.3-3.7-3.43.53.13.33.13.2-3.3-3.33.23.23.3-3.02.83.23.32.8-3.2-3.3
Weight adjusted by age0.10.20.60.20.30.70.6-0.7-0.2-0.3-0.5-0.50.40.5-0.5-0.4-0.6-0.1-0.4-0.4-0.50.30.60.5
Bone surface1.93.45.72.32.10.81.2-0.9-2.4-2.0-2.2-2.21.81.8-2.2-2.2-1.82.4-2.2-1.6-0.9-2.11.40.8
Bone volume1.93.55.72.42.10.91.4-0.9-2.4-2.1-2.1-2.11.91.9-2.2-2.2-1.82.3-2.1-1.6-0.9-2.11.50.8
Breakpoint value in progressive ratio session0.91.01.80.90.90.61.1-0.5-0.8-1.0-1.2-1.21.01.0-1.2-1.0-1.11.3-1.1-0.9-0.8-1.31.20.8
Number of licking bursts0.10.10.70.4-0.0-0.8-0.60.6-0.30.0-0.1-0.1-0.2-0.1-0.1-0.20.20.6-0.20.40.4-0.4-0.2-0.3
Context. condit. distance diff. score0.00.00.1-0.20.10.30.2-0.3-0.0-0.1-0.0-0.00.10.10.0-0.0-0.0-0.0-0.1-0.1-0.3-0.00.00.3
Locomotion velocity, session 10.20.20.8-0.2-0.1-0.9-0.40.8-0.00.20.30.3-0.2-0.20.20.10.3-0.20.20.30.90.3-0.3-0.9
Locomotion distance, session 11.11.42.71.51.50.30.8-0.4-1.7-1.4-1.3-1.31.21.2-1.3-1.5-1.11.5-1.2-1.0-0.3-1.60.80.3
Locomotion velocity, session 20.30.30.5-0.6-0.5-0.6-0.70.60.50.60.60.6-0.6-0.60.70.60.7-0.50.60.60.40.3-0.7-0.4
Locomotion distance, session 20.00.00.2-0.00.0-0.5-0.20.5-0.10.00.10.0-0.1-0.10.0-0.00.1-0.10.20.10.3-0.0-0.2-0.3
Locomotion velocity, session 30.91.01.70.70.91.31.1-1.3-0.8-1.0-0.9-1.01.01.1-1.0-1.0-1.20.7-0.8-1.1-1.2-0.71.31.2
Locomotion distance, session 30.60.61.00.90.90.50.6-0.4-1.0-0.9-0.9-0.90.80.9-0.8-1.0-0.81.0-0.7-0.8-0.5-0.90.80.4
Stereotopy head waving bouts, day 32.42.83.61.41.61.91.8-1.9-1.5-1.6-1.6-1.61.71.7-1.6-1.6-1.81.3-1.7-1.8-1.9-1.31.81.9
Stereotopy head waving duration, day 30.30.40.70.20.40.80.8-0.8-0.3-0.5-0.5-0.50.60.6-0.5-0.5-0.70.2-0.5-0.7-0.8-0.30.80.9
Locomotion velocity, session 70.91.01.61.31.00.30.7-0.3-1.2-1.1-1.3-1.21.01.1-1.2-1.2-1.10.9-1.2-0.9-0.3-0.91.00.3
Locomotion distance, session 70.10.20.90.10.1-0.9-0.31.0-0.3-0.1-0.4-0.40.00.1-0.4-0.3-0.1-0.1-0.30.00.80.0-0.0-0.7
Stereotopy head waving bouts, day 70.00.10.20.30.10.5-0.1-0.5-0.1-0.10.10.10.10.10.1-0.1-0.10.2-0.1-0.1-0.4-0.20.10.5
Stereotopy head waving duration, day 70.60.72.00.70.61.40.8-1.4-0.5-0.7-0.5-0.50.70.7-0.5-0.6-0.70.6-0.7-0.8-1.2-0.60.81.2
Locomotion velocity, session 80.30.30.50.30.60.60.7-0.6-0.5-0.6-0.7-0.60.60.6-0.6-0.5-0.60.1-0.6-0.7-0.5-0.10.50.5
Locomotion distance, session 80.20.30.50.50.70.40.4-0.3-0.7-0.6-0.6-0.60.60.5-0.6-0.6-0.50.5-0.6-0.5-0.4-0.70.30.4
Degree of sensitization distance1.01.02.0-0.9-1.0-1.4-1.21.30.91.00.80.8-1.0-1.00.80.91.0-1.00.71.01.21.0-1.1-1.2
Degree of sensitization stereotypy0.20.20.5-0.2-0.50.0-0.6-0.00.50.50.70.7-0.5-0.50.70.50.5-0.30.50.50.00.2-0.40.1
Conditioned locomotion3.43.95.11.92.02.22.1-2.2-1.8-1.9-1.9-1.92.01.9-1.8-1.8-1.91.7-1.8-2.0-2.2-1.91.92.2
Cocaine response after cond. corrected0.40.51.40.90.80.10.4-0.1-0.9-0.8-0.8-0.90.70.7-0.9-0.8-0.60.9-0.9-0.5-0.1-1.20.50.1
Cocaine response after cond. not corrected1.21.42.81.61.30.80.9-0.8-1.4-1.3-1.2-1.21.21.1-1.2-1.3-1.11.5-1.3-0.9-0.8-1.70.90.8
Cocaine response before conditioning1.92.34.31.61.52.01.6-2.1-1.3-1.4-1.1-1.11.51.4-1.1-1.3-1.41.3-1.2-1.5-2.1-1.11.32.1
Saline control response0.81.12.20.91.01.41.0-1.4-0.9-1.0-0.9-0.91.01.0-0.9-0.9-1.00.7-0.9-1.1-1.4-0.70.91.5
Bone: connectivity density3.75.88.52.82.61.72.0-1.7-2.8-2.6-2.6-2.62.42.5-2.6-2.7-2.42.9-2.6-2.2-1.8-2.82.31.7
Bone: cortical apparent density0.30.51.01.00.70.30.4-0.4-0.8-0.7-0.7-0.70.60.6-0.8-0.8-0.61.0-0.7-0.5-0.4-1.00.50.4
Bone: cortical area0.40.61.31.00.9-0.20.20.1-1.2-0.8-0.9-0.90.70.7-0.9-1.0-0.61.1-1.0-0.50.1-1.00.4-0.1
Bone: cortical porosity1.61.73.31.21.31.81.5-1.8-1.1-1.2-1.0-1.01.31.2-1.0-1.1-1.21.2-1.0-1.4-1.7-0.91.31.6
Bone: cortical porosity1.51.62.31.21.31.51.5-1.5-1.2-1.3-1.1-1.11.31.3-1.1-1.2-1.31.3-1.1-1.4-1.4-0.91.31.3
Bone: cortical thickness0.10.10.40.1-0.1-0.6-0.70.5-0.20.10.20.2-0.3-0.30.20.00.40.20.20.40.6-0.2-0.5-0.5
Bone: cortical thickness1.11.31.91.31.30.50.9-0.6-1.4-1.2-1.3-1.41.21.2-1.4-1.3-1.11.4-1.2-1.1-0.6-1.41.10.6
Bone: cortical tissue density0.20.30.70.90.60.20.3-0.2-0.7-0.6-0.6-0.60.50.5-0.6-0.6-0.40.8-0.5-0.3-0.3-0.80.40.3
Condit. Reinf. active minus inactive responses0.91.01.9-0.7-1.0-1.3-1.21.40.81.00.80.8-1.0-1.00.80.81.0-0.70.91.21.30.6-0.9-1.3
Condit. Reinf. active-inactive response ratio1.01.02.3-0.8-1.0-1.4-1.01.50.91.00.80.8-1.0-0.90.80.90.9-0.70.91.11.40.7-0.8-1.4
Condit. Reinf. active responses0.10.10.50.60.3-0.2-0.10.2-0.4-0.3-0.3-0.20.20.2-0.2-0.3-0.10.6-0.30.00.1-0.70.1-0.1
Condit. Reinf. inactive responses1.41.72.61.61.41.11.0-1.1-1.5-1.4-1.2-1.11.31.3-1.2-1.4-1.21.5-1.4-1.2-1.3-1.61.11.3
Incentive salience index mean0.10.10.40.3-0.0-0.6-0.30.6-0.10.0-0.2-0.1-0.1-0.1-0.1-0.10.10.30.00.30.5-0.3-0.1-0.6
Condit. Reinf. lever presses0.50.71.41.20.90.30.7-0.4-1.0-0.9-0.9-0.90.80.8-0.9-0.9-0.81.1-0.8-0.6-0.5-1.20.70.4
Condit. Reinf. active minus inactive responses4.35.68.82.02.22.92.4-3.0-2.1-2.2-2.1-2.12.32.3-2.0-2.2-2.32.2-2.0-2.3-2.9-2.32.42.9
Condit. Reinf. active-inactive response ratio1.61.85.00.91.12.21.2-2.2-1.0-1.1-0.8-0.81.21.2-0.8-1.0-1.11.1-0.9-1.2-2.2-1.11.22.2
Condit. Reinf. active responses3.44.75.52.12.02.32.2-2.3-2.0-2.1-2.1-2.12.22.2-2.0-2.1-2.32.1-2.0-2.1-2.3-2.22.32.3
Condit. Reinf. inactive responses1.31.72.51.51.30.51.3-0.5-1.4-1.4-1.6-1.61.41.4-1.5-1.4-1.51.5-1.5-1.2-0.5-1.51.40.5
Condit. Reinf. lever presses2.13.03.81.61.71.91.7-2.0-1.6-1.7-1.8-1.71.71.7-1.7-1.6-1.61.7-1.6-1.7-1.9-1.91.51.9
Condit. Reinf. lever reinforcers received3.24.45.62.02.02.32.1-2.4-1.9-2.0-2.0-2.02.12.1-1.9-2.0-2.22.0-1.9-2.1-2.3-2.12.22.3
Conditioned reinforcement - actives1.83.26.30.91.62.32.5-2.3-1.1-1.6-1.8-1.81.81.7-1.8-1.3-1.90.6-1.7-2.3-2.2-0.41.92.0
Conditioned reinforcement - inactives2.94.36.62.62.22.02.2-2.3-2.1-2.1-2.0-2.02.12.1-1.9-2.1-2.12.1-2.1-1.7-2.1-1.72.02.1
Conditioned locomotion0.71.02.4-0.20.51.31.6-1.4-0.1-0.6-1.0-0.90.80.8-0.8-0.4-1.0-0.6-0.7-1.4-1.31.01.01.2
Patch foraging indifference point 0 sec0.40.71.1-0.6-1.0-0.9-0.90.80.80.91.00.9-0.9-0.80.80.70.7-0.61.10.90.80.9-0.7-0.8
Patch foraging indifference point AUC0.81.22.61.41.30.20.6-0.3-1.6-1.3-1.3-1.21.11.1-1.2-1.4-1.01.4-1.2-1.2-0.6-1.10.90.5
Delay disc. indifference point, 0s delay3.33.65.5-1.5-1.8-2.3-1.92.41.91.91.81.8-2.0-2.01.82.02.1-1.31.72.12.11.1-2.2-2.2
Delay disc. indifference point, 16s delay0.10.11.00.40.20.00.1-0.3-0.2-0.2-0.2-0.10.20.2-0.0-0.2-0.10.7-0.2-0.1-0.2-1.00.20.1
Delay disc. indifference point, 2s delay0.20.20.5-0.3-0.4-0.5-0.50.70.40.40.40.3-0.5-0.50.40.40.5-0.20.20.50.70.2-0.6-0.7
Delay disc. indifference point, 24s delay1.01.15.21.41.00.81.0-1.0-0.9-0.9-1.0-1.10.90.9-0.9-0.8-0.81.8-0.9-0.7-0.4-2.30.80.3
Delay disc. indifference point, 4s delay0.10.10.40.30.0-0.6-0.20.6-0.1-0.0-0.1-0.1-0.0-0.0-0.0-0.10.00.2-0.20.10.2-0.3-0.1-0.2
Delay disc. indifference point, 8s delay0.10.10.80.40.2-0.00.2-0.0-0.1-0.1-0.3-0.30.10.1-0.2-0.1-0.10.8-0.2-0.00.0-0.90.0-0.1
Indifference point function ln k0.10.10.8-0.00.20.90.7-0.70.0-0.2-0.2-0.20.30.2-0.3-0.1-0.3-0.0-0.3-0.3-0.5-0.00.30.4
Indifference point function log k0.10.10.8-0.00.20.90.7-0.70.0-0.2-0.2-0.20.30.2-0.3-0.1-0.3-0.0-0.3-0.3-0.5-0.00.30.4
Patch foraging total patch changes 0 sec0.30.61.0-0.5-0.9-0.9-1.00.80.80.90.90.8-0.8-0.80.70.70.7-0.51.00.90.70.8-0.7-0.6
Patch foraging total patch changes 12 sec1.11.52.3-1.0-1.3-1.5-1.41.41.11.21.31.3-1.2-1.21.21.11.2-1.01.41.21.11.3-1.2-1.1
Patch foraging total patch changes 18 sec0.10.20.8-0.1-0.4-0.9-0.80.70.20.40.30.2-0.4-0.40.20.20.4-0.30.40.30.60.6-0.4-0.5
Patch foraging total patch changes 24 sec0.71.22.6-1.2-1.2-1.1-1.20.91.01.11.11.1-1.1-1.11.01.01.1-1.31.31.00.61.6-1.1-0.6
Patch foraging total patch changes 6 sec0.20.31.0-0.1-0.6-1.0-0.80.90.30.50.50.5-0.5-0.40.50.30.4-0.10.80.50.80.5-0.3-0.8
Patch foraging time to switch 0 sec0.00.00.1-0.2-0.3-0.1-0.30.10.30.20.20.2-0.2-0.10.20.10.1-0.2-0.00.30.1-0.20.00.0
Patch foraging water rate 0 sec0.10.10.50.00.30.70.6-0.6-0.1-0.2-0.2-0.30.30.2-0.3-0.1-0.20.0-0.0-0.5-0.70.30.10.5
Patch foraging water rate 12 sec0.81.62.4-1.6-1.3-0.6-0.90.71.61.31.41.3-1.3-1.31.21.51.3-1.61.51.00.71.6-1.3-0.8
Patch foraging water rate 18 sec0.40.51.1-1.0-0.70.4-0.1-0.11.00.71.01.0-0.6-0.70.91.00.7-1.00.70.50.21.0-0.7-0.3
Patch foraging water rate 24 sec1.62.33.9-2.0-1.7-0.9-1.10.92.01.71.51.5-1.6-1.61.41.91.5-1.91.71.20.91.6-1.4-1.0
Patch foraging water rate 6 sec0.91.42.0-1.4-1.1-0.5-0.70.71.41.21.41.4-1.1-1.21.41.41.3-1.41.20.90.71.4-1.3-0.8
Seeking ratio, delayed vs. immediate footshock0.10.10.7-0.3-0.1-0.0-0.00.10.10.10.20.2-0.1-0.10.10.1-0.0-0.70.0-0.10.00.8-0.10.0
Distance traveled before self-admin0.00.00.1-0.00.00.1-0.1-0.00.00.10.10.2-0.1-0.20.20.20.3-0.10.10.10.20.0-0.4-0.3
Distance traveled after self-admin2.32.83.4-1.7-1.5-1.7-1.81.81.41.61.61.7-1.7-1.71.61.61.8-1.61.61.51.81.4-1.8-1.8
Extensor digitorum longus weight4.517.618.74.34.24.14.0-4.2-4.2-4.2-4.2-4.24.24.2-4.1-4.2-4.14.3-4.3-4.2-4.3-4.34.04.3
Bone: elastic displacement0.80.91.60.80.90.91.3-0.9-0.7-0.9-1.0-1.00.90.9-1.1-0.8-1.00.9-0.7-0.9-1.0-0.91.00.9
Bone: elastic work0.81.11.61.11.10.61.1-0.6-1.1-1.1-1.2-1.21.01.1-1.2-1.1-1.11.2-1.1-1.0-0.7-1.21.00.6
Bone: endosteal estimation0.51.22.21.21.20.00.8-0.0-1.3-1.1-1.4-1.41.01.1-1.4-1.3-1.11.2-1.5-1.0-0.1-1.11.00.1
Bone: endosteal perimeter0.20.51.10.80.7-0.20.40.2-0.8-0.7-0.9-0.90.60.6-0.9-0.8-0.70.7-1.0-0.60.1-0.80.5-0.2
Epididymis fat weight16.054.962.3-7.9-7.9-7.7-7.37.57.87.77.27.2-7.6-7.57.17.57.3-7.57.27.37.07.4-7.0-6.9
Delta time in closed arm before/after self-admin0.00.00.2-0.2-0.0-0.2-0.2-0.1-0.1-0.0-0.2-0.20.00.0-0.2-0.1-0.10.1-0.4-0.00.0-0.20.1-0.1
Delta time in open arm before/after self-admin0.10.10.20.40.30.20.4-0.3-0.3-0.4-0.4-0.30.40.4-0.4-0.4-0.50.3-0.3-0.4-0.3-0.30.50.4
Diff in mean of infusions in LGA sessions0.00.00.20.30.1-0.20.10.2-0.1-0.1-0.2-0.20.10.1-0.4-0.2-0.20.3-0.0-0.1-0.1-0.10.20.2
Delay discount exponential model param0.30.42.0-0.9-0.6-0.1-0.50.10.50.50.70.7-0.5-0.50.60.50.5-1.10.70.40.21.4-0.4-0.1
Extinction: sum of active levers before priming0.30.41.00.70.50.30.4-0.5-0.5-0.5-0.6-0.60.50.6-0.6-0.6-0.50.9-0.5-0.4-0.7-1.00.50.8
Active lever presses in extinction session 60.90.91.90.50.80.91.4-0.7-0.6-0.9-1.1-1.01.01.0-1.0-0.8-1.10.3-0.8-1.2-1.1-0.11.31.0
Bone: final force0.10.10.30.20.3-0.40.00.3-0.5-0.3-0.6-0.50.20.2-0.5-0.4-0.20.3-0.5-0.20.3-0.30.1-0.4
Bone: final moment0.10.20.30.30.4-0.40.00.4-0.6-0.4-0.6-0.50.30.3-0.5-0.5-0.30.4-0.5-0.30.4-0.40.2-0.4
Food consumed during 24 hour testing period0.10.10.30.50.40.30.2-0.3-0.6-0.4-0.3-0.30.40.4-0.3-0.5-0.30.5-0.4-0.3-0.3-0.40.30.4
Glucose0.20.40.8-0.6-0.6-0.7-0.70.50.50.60.50.5-0.6-0.60.50.50.6-0.70.50.60.60.9-0.7-0.7
Heart weight3.35.16.2-2.0-2.1-2.3-2.42.22.02.22.42.5-2.2-2.32.52.12.4-2.22.02.32.22.2-2.4-2.2
Delay discount hyperbolic model param0.20.21.3-0.7-0.40.1-0.3-0.10.40.40.50.5-0.3-0.40.40.40.3-0.90.60.20.01.2-0.30.1
Intermittent access intake day 1-15 change0.10.21.00.00.40.60.5-0.7-0.2-0.3-0.4-0.40.40.3-0.3-0.1-0.2-0.1-0.4-1.0-0.80.30.30.5
Intermittent access intake escalation0.00.10.4-0.20.10.30.1-0.40.1-0.0-0.1-0.00.0-0.00.00.20.1-0.2-0.1-0.6-0.40.5-0.00.2
Intermittent access intake escalation 20.00.00.3-0.00.10.1-0.2-0.3-0.1-0.00.10.20.0-0.10.20.00.2-0.3-0.2-0.4-0.20.5-0.1-0.0
Intermitt. access day 1 inactive lever presses0.51.93.21.21.31.61.5-1.8-1.3-1.3-1.2-1.31.41.4-1.3-1.4-1.41.1-1.2-1.2-1.7-0.81.41.8
Intermitt. access day 15 inactive lever presses3.26.59.52.72.82.12.3-2.4-3.1-2.8-2.5-2.52.72.7-2.5-3.0-2.72.0-2.6-2.5-2.4-1.92.62.5
Intermitt. access escalation Index0.70.92.7-0.8-0.9-1.6-1.61.50.40.80.90.8-0.8-0.80.80.50.9-0.91.00.81.10.8-0.7-0.9
Intermittent access day 1 total infusions3.35.36.62.32.32.52.6-2.4-2.2-2.3-2.3-2.32.42.4-2.2-2.3-2.51.9-2.0-2.1-2.4-2.02.42.4
Intermittent access day 15 total infusions1.52.33.11.31.61.81.7-1.7-1.4-1.6-1.5-1.51.61.5-1.4-1.4-1.51.0-1.3-1.8-1.7-1.01.51.6
Intermittent access terminal intake (last 3 days)2.53.34.71.51.92.12.0-2.1-1.7-1.8-1.8-1.71.91.8-1.6-1.7-1.81.3-1.6-2.0-2.2-1.21.82.0
Intermittent access total infusions2.83.35.31.51.72.32.3-2.2-1.4-1.7-1.9-1.81.81.8-1.7-1.6-1.91.3-1.6-1.9-2.2-1.21.92.0
Intermittent access day 1 locomotion2.02.64.01.41.51.71.8-1.9-1.4-1.6-1.6-1.51.61.6-1.4-1.5-1.71.5-1.3-1.4-1.9-1.41.62.0
Intermittent access day 15 total locomotion0.30.51.30.70.60.80.8-1.1-0.5-0.6-0.9-0.70.60.7-0.6-0.6-0.70.5-0.7-0.6-1.1-0.10.71.1
Intermittent access total locomotion0.70.82.10.60.61.11.2-1.4-0.3-0.7-1.1-0.90.80.8-0.8-0.6-1.00.4-0.7-0.8-1.4-0.10.91.4
Intermittent access standard deviation0.81.72.31.31.31.41.4-1.5-1.2-1.3-1.3-1.31.31.3-1.3-1.3-1.41.1-1.2-1.3-1.4-0.91.31.3
Left kidney weight0.00.00.1-0.3-0.2-0.1-0.10.30.30.20.10.2-0.2-0.20.10.20.1-0.20.10.10.4-0.0-0.1-0.3
Right kidney weight0.52.22.9-1.2-1.5-1.5-1.51.51.51.51.61.6-1.5-1.51.61.51.6-0.81.31.71.60.7-1.5-1.6
Cocaine induced anxiety0.20.30.50.60.50.20.3-0.7-0.6-0.5-0.5-0.50.50.5-0.5-0.6-0.50.4-0.5-0.5-0.3-0.30.50.5
Post-drug Anxiety1.41.52.4-0.9-1.2-1.5-1.41.31.11.21.21.2-1.2-1.21.21.11.3-0.91.21.31.51.1-1.3-1.4
Baseline Anxiety3.43.96.4-1.9-2.0-2.1-1.92.52.02.01.91.9-2.0-2.01.92.01.9-1.62.12.12.01.7-2.0-2.1
Tail length0.41.72.4-1.4-1.2-1.2-1.11.51.41.31.21.3-1.2-1.31.41.41.3-1.51.01.01.51.4-1.3-1.5
Length with tail1.77.610.1-3.2-2.8-2.4-2.32.63.02.82.72.7-2.7-2.82.73.02.8-3.02.52.42.82.8-2.7-2.9
Length without tail0.62.02.8-1.7-1.4-1.4-1.21.41.51.41.31.3-1.4-1.41.21.51.4-1.51.21.41.61.3-1.4-1.7
LgA early post infusion interval0.91.22.1-1.4-1.3-0.8-1.00.71.31.21.11.1-1.1-1.11.21.21.1-1.01.21.00.80.8-1.0-0.7
LgA late post infusion interval1.01.22.60.40.91.01.6-1.1-0.7-1.0-1.3-1.41.11.1-1.5-0.9-1.40.6-1.0-1.3-1.0-0.31.41.0
LgA early loading2.64.85.82.12.21.72.2-1.7-2.3-2.3-2.4-2.42.32.3-2.4-2.3-2.42.0-2.3-2.4-1.9-2.02.41.9
LgA late loading0.41.01.71.21.10.80.9-0.9-1.1-1.0-1.1-1.11.01.0-1.0-1.0-0.91.2-1.1-1.0-0.8-1.30.90.7
LgA early average infusions2.32.93.51.91.71.21.6-1.2-1.8-1.8-1.9-1.81.71.8-1.8-1.8-1.81.7-1.9-1.7-1.5-1.31.71.5
LgA late average infusions1.52.13.0-0.9-1.3-1.3-1.61.41.41.41.41.6-1.5-1.51.71.51.6-1.11.51.61.41.1-1.7-1.5
LgA early timeout3.53.74.41.82.01.91.9-1.8-2.0-2.0-2.1-2.01.91.9-2.0-2.0-2.01.8-2.1-2.0-1.9-1.61.81.8
LgA late timeout0.40.51.3-0.5-0.8-0.9-1.20.50.60.70.60.7-0.8-0.80.70.70.9-0.20.60.80.30.4-0.9-0.3
LgA early titration1.11.62.01.41.31.01.1-1.0-1.4-1.3-1.3-1.31.31.3-1.3-1.4-1.31.1-1.4-1.2-1.2-1.01.21.1
LgA late titration1.62.53.6-1.2-1.4-1.5-1.91.61.31.51.51.7-1.6-1.61.81.51.8-1.41.31.71.71.2-1.9-1.7
LgA total infusion0.30.40.7-0.2-0.6-0.8-0.70.70.60.60.50.6-0.7-0.70.60.70.7-0.60.50.70.80.7-0.8-0.8
Times rat made contact with spout1.82.03.21.61.41.31.2-1.3-1.5-1.4-1.5-1.51.41.4-1.5-1.5-1.31.7-1.5-1.2-1.3-1.81.21.3
Lifetime Intake3.03.76.01.51.82.32.4-2.2-1.5-1.8-2.0-2.01.91.9-1.9-1.7-2.11.3-1.8-2.0-2.2-1.22.12.1
Liver weight, left4.06.67.6-2.4-2.5-2.7-2.52.82.52.62.62.6-2.6-2.62.62.52.5-2.52.52.62.72.4-2.5-2.7
Liver weight, right9.516.619.2-4.3-4.2-3.8-3.93.74.24.24.34.3-4.1-4.14.44.24.1-4.44.14.13.64.2-3.9-3.5
Locomotor activity0.30.51.3-0.4-0.8-1.2-0.90.90.70.70.60.6-0.8-0.70.60.60.7-0.00.71.00.80.1-0.6-0.8
Locomotor testing distance0.10.20.60.40.2-0.10.1-0.2-0.4-0.3-0.4-0.50.30.4-0.5-0.5-0.40.8-0.3-0.2-0.2-0.80.60.3
Locomotor testing rearing0.71.42.30.70.81.01.3-1.3-0.8-1.0-1.3-1.41.11.2-1.5-1.0-1.41.0-1.1-1.3-1.3-0.91.51.3
Locomotion in novel chamber0.20.21.4-1.0-0.5-0.10.10.30.60.40.20.2-0.2-0.20.20.50.1-1.20.4-0.30.20.90.10.0
Locomotion in novel chamber post-restriction2.64.35.7-2.2-2.3-1.9-2.01.72.42.22.22.1-2.1-2.12.02.22.0-2.32.32.11.72.0-1.8-1.6
Fecal boli incidents, locomotor time 10.20.30.70.40.60.90.7-0.7-0.6-0.6-0.4-0.30.60.6-0.3-0.5-0.50.4-0.4-0.7-0.8-0.50.60.8
Change in fecal boli incidents, locomotor task4.54.56.7-2.0-2.2-2.2-2.12.62.12.12.01.9-2.1-2.11.92.12.0-1.92.12.22.42.0-2.1-2.3
Time >=10cm from walls, locomotor time 10.10.10.2-0.2-0.2-0.1-0.00.10.30.30.30.1-0.3-0.30.10.40.3-0.00.40.30.2-0.3-0.4-0.2
Bouts of movement, locomotor time 11.51.73.01.11.31.30.9-1.5-1.5-1.4-1.6-1.41.31.3-1.2-1.4-1.21.3-1.7-1.3-1.0-1.51.21.0
Total resting periods, locomotor time 11.82.03.31.31.51.31.0-1.3-1.6-1.5-1.7-1.51.41.4-1.3-1.6-1.41.4-1.8-1.4-1.0-1.51.31.0
Rest time, locomotor task time 10.10.10.5-0.2-0.2-0.1-0.10.50.20.20.20.2-0.2-0.20.20.20.1-0.60.20.20.70.3-0.1-0.7
Distance moved, locomotor task time 10.81.21.8-1.2-1.1-1.3-1.00.91.11.11.21.3-1.1-1.11.21.11.2-0.91.21.20.70.7-1.0-0.7
Vertical activity count, locomotor time 10.20.61.2-0.9-0.7-1.1-0.70.80.70.70.70.8-0.7-0.80.80.80.8-0.30.90.90.60.2-0.8-0.7
Time >=10cm from walls, locomotor time 20.30.40.80.60.70.50.9-0.7-0.4-0.6-0.7-0.90.60.5-0.7-0.4-0.6-0.0-0.7-0.7-0.7-0.20.40.8
Bouts of movement, locomotor time 20.10.10.4-0.4-0.20.1-0.7-0.20.20.30.20.0-0.4-0.40.20.30.4-0.20.10.30.40.1-0.6-0.4
Total resting periods, locomotor time 20.00.00.3-0.10.10.4-0.4-0.5-0.2-0.1-0.2-0.3-0.0-0.0-0.2-0.10.10.1-0.3-0.00.1-0.1-0.3-0.1
Rest time, locomotor task time 21.01.32.21.51.21.00.8-0.8-1.3-1.2-1.2-1.21.11.2-1.2-1.3-1.21.4-1.2-1.0-0.7-1.31.10.7
Distance moved, locomotor task time 20.91.11.8-1.2-1.0-1.3-0.70.91.21.11.01.1-1.0-1.01.11.11.0-1.31.00.90.51.1-0.9-0.5
Vertical activity count, locomotor time 20.40.51.1-0.9-0.7-0.7-0.30.70.80.70.60.6-0.7-0.70.60.80.7-1.10.60.50.61.0-0.7-0.6
Light reinforcement 12.35.78.52.82.51.91.6-2.0-2.9-2.5-2.5-2.52.42.4-2.4-2.7-2.32.9-2.6-2.2-1.8-2.62.21.8
Light reinforcement 22.53.86.22.42.21.71.4-1.6-2.4-2.1-1.9-2.01.91.9-2.0-2.2-1.82.5-2.2-1.7-1.5-2.11.71.4
Bone: marrow area0.51.22.21.21.10.10.8-0.1-1.3-1.1-1.4-1.41.01.1-1.4-1.3-1.11.2-1.5-1.0-0.1-1.11.00.1
Bone: maximum diameter0.81.62.71.51.30.10.6-0.2-1.6-1.3-1.6-1.61.21.2-1.6-1.5-1.21.7-1.7-1.1-0.1-1.51.00.1
Bone: maximum force0.10.20.40.30.5-0.00.30.0-0.6-0.5-0.6-0.60.40.4-0.6-0.5-0.40.4-0.6-0.40.0-0.40.3-0.0
Bone: maximum moment0.20.30.50.50.60.00.40.0-0.7-0.6-0.7-0.70.50.5-0.7-0.6-0.50.6-0.7-0.5-0.0-0.60.4-0.0
Mean time between licks in bursts1.63.84.5-1.9-2.0-1.9-1.92.01.92.02.12.1-2.0-2.02.02.02.0-1.82.12.01.91.7-1.9-1.9
Mean num. licks in bursts0.20.41.40.30.61.20.8-0.9-0.4-0.5-0.5-0.50.60.6-0.4-0.4-0.60.2-0.4-0.7-0.8-0.40.50.7
Cd content in liver0.00.00.1-0.00.0-0.3-0.2-0.0-0.1-0.0-0.1-0.1-0.00.0-0.1-0.1-0.0-0.0-0.0-0.00.0-0.1-0.00.0
Co content in liver5.56.48.02.82.72.22.4-2.1-2.7-2.6-2.7-2.72.52.5-2.7-2.6-2.42.8-2.7-2.5-2.1-2.72.22.1
Cu content in liver0.10.10.30.40.40.30.6-0.4-0.3-0.3-0.2-0.30.40.4-0.3-0.3-0.30.3-0.3-0.4-0.4-0.30.40.4
Fe content in liver1.01.32.70.81.11.01.6-1.0-0.9-1.1-1.0-1.11.31.3-1.2-1.1-1.40.7-0.9-1.3-1.0-0.71.61.0
K content in liver0.30.30.70.60.5-0.7-0.10.8-0.8-0.5-0.6-0.60.40.4-0.5-0.7-0.30.5-0.7-0.20.8-0.60.2-0.8
Mg content in liver0.30.40.70.70.5-0.7-0.20.7-0.8-0.5-0.6-0.60.40.4-0.6-0.7-0.30.6-0.7-0.20.7-0.80.2-0.7
Mn content in liver0.10.10.4-0.00.1-0.6-0.20.6-0.3-0.2-0.4-0.40.10.2-0.5-0.4-0.3-0.0-0.4-0.10.6-0.10.3-0.6
Na content in liver0.50.51.10.70.90.71.0-0.6-0.8-0.8-0.7-0.60.80.8-0.6-0.7-0.70.6-0.7-0.9-0.6-0.60.70.5
Rb content in liver0.10.10.30.1-0.1-0.5-0.20.6-0.10.0-0.0-0.0-0.00.0-0.1-0.1-0.00.0-0.00.10.6-0.20.1-0.6
Se content in liver0.10.10.5-0.6-0.4-0.1-0.1-0.00.40.30.20.1-0.2-0.20.10.20.1-0.70.20.10.00.7-0.00.0
Sr content in liver0.20.10.3-0.3-0.2-0.3-0.20.20.40.30.40.5-0.3-0.40.50.50.5-0.30.40.30.30.2-0.5-0.3
Zn content in liver1.11.32.6-0.9-1.0-1.6-1.11.50.91.01.00.9-1.0-1.10.90.91.1-1.00.91.01.51.0-1.1-1.5
Bone: minimum diameter0.20.41.6-0.1-0.3-1.2-0.71.20.10.30.10.1-0.4-0.40.10.10.4-0.20.10.51.10.4-0.5-1.2
Time in familiar zone, hab. session 10.90.91.8-0.9-0.9-1.3-1.01.30.70.80.70.8-0.9-0.80.70.70.8-1.00.70.81.31.0-0.8-1.2
Time in novel zone, hab. session 10.30.30.9-0.9-0.80.1-0.2-0.20.90.70.70.6-0.5-0.50.50.70.4-0.90.70.4-0.00.8-0.30.0
Total zone transitions, hab. session 10.10.10.20.40.40.40.2-0.3-0.4-0.4-0.3-0.30.30.3-0.5-0.3-0.30.3-0.4-0.3-0.4-0.50.10.4
Total locomotion distance, hab. session 10.10.20.30.50.50.20.3-0.1-0.5-0.5-0.4-0.50.40.4-0.5-0.5-0.40.4-0.6-0.3-0.2-0.40.20.2
Locomotion velocity, hab. session 10.81.11.81.41.30.80.9-0.7-1.3-1.2-1.0-1.11.11.0-1.2-1.2-1.01.3-1.1-0.9-0.8-1.20.80.7
Time in familiar zone, hab. session 20.00.00.0-0.20.00.1-0.2-0.1-0.1-0.0-0.2-0.20.00.0-0.2-0.1-0.0-0.0-0.2-0.1-0.10.00.00.1
Time in novel zone, hab. session 20.50.50.7-0.6-0.7-0.8-0.40.80.80.70.80.8-0.7-0.70.80.80.6-0.60.80.70.80.6-0.6-0.8
Total zone transitions, hab. session 20.10.10.30.40.2-0.3-0.20.3-0.4-0.2-0.2-0.30.10.1-0.3-0.3-0.10.4-0.3-0.00.4-0.6-0.0-0.4
Total locomotion distance, hab. session 20.10.10.40.60.40.0-0.10.0-0.6-0.4-0.3-0.30.30.3-0.3-0.5-0.20.6-0.4-0.10.1-0.60.1-0.1
Locomotion velocity, hab. session 20.20.30.70.80.60.20.1-0.2-0.8-0.6-0.5-0.50.50.5-0.5-0.7-0.40.8-0.6-0.3-0.2-0.90.30.1
Novel to familiar place preference ratio1.01.11.4-0.9-1.1-1.0-1.21.01.11.11.01.0-1.1-1.11.11.11.1-0.71.11.21.10.8-1.2-1.1
Novelty place preference1.61.72.0-1.2-1.4-1.2-1.41.21.41.41.31.3-1.4-1.41.31.41.4-1.01.41.41.31.1-1.4-1.3
Time in novel zone, NPP test1.81.92.2-1.4-1.5-1.3-1.41.21.51.41.41.4-1.4-1.41.41.41.4-1.11.51.41.31.2-1.4-1.3
Total zone transitions, NPP test1.31.82.51.51.51.21.2-1.2-1.5-1.4-1.2-1.31.41.4-1.3-1.4-1.31.5-1.2-1.3-1.3-1.61.21.2
Total locomotion distance, NPP test1.82.53.01.71.71.71.4-1.5-1.7-1.6-1.4-1.51.61.6-1.5-1.6-1.51.6-1.5-1.5-1.6-1.71.41.5
Locomotion velocity, NPP test2.94.05.22.32.11.91.7-1.8-2.2-2.1-2.0-2.02.02.0-2.0-2.1-1.92.2-2.0-1.9-1.9-2.31.81.8
Intraocular pressure5.98.59.8-2.9-3.1-2.9-3.12.83.03.02.92.9-3.0-3.02.82.93.0-2.53.03.13.02.3-2.8-3.0
Delta distance traveled before/after self-admin1.92.02.6-1.6-1.4-1.6-1.61.61.21.41.51.4-1.4-1.41.31.21.4-1.61.41.21.41.6-1.3-1.3
Delta ambulatory time before/after self-admin0.30.41.0-0.7-0.5-1.0-0.81.00.30.50.60.6-0.5-0.50.40.40.6-0.60.50.40.70.6-0.5-0.6
Parametrial fat weight12.830.038.7-5.1-5.4-5.8-6.25.34.95.45.45.5-5.6-5.65.65.25.7-5.25.25.55.65.1-5.9-5.6
Pavlov. Cond. lever latency1.41.73.1-1.8-1.5-0.8-1.00.91.61.41.51.4-1.3-1.31.41.51.3-1.61.41.10.81.6-1.2-0.8
Pavlov. Cond. magazine entry latency0.00.10.20.40.30.00.0-0.1-0.4-0.3-0.2-0.20.20.2-0.2-0.3-0.20.2-0.2-0.10.1-0.30.2-0.1
Pavlov. Cond. change in total contacts0.00.00.10.30.2-0.10.10.1-0.2-0.2-0.1-0.10.10.1-0.1-0.2-0.10.2-0.1-0.00.2-0.30.1-0.2
Pavlov. Cond. index score0.50.61.41.20.90.20.4-0.4-1.1-0.9-0.9-0.80.80.8-0.8-1.0-0.71.0-0.8-0.5-0.2-1.10.70.1
Pavlov. Cond. latency score0.50.61.41.20.90.20.4-0.4-1.1-0.9-0.9-0.80.70.8-0.8-1.0-0.71.0-0.8-0.5-0.1-1.10.60.1
Pavlov. Cond. lever contacts0.91.02.11.41.20.50.8-0.6-1.3-1.1-1.2-1.11.01.0-1.1-1.2-0.91.3-1.1-0.8-0.4-1.30.90.4
Pavlov. Cond. magazine entry number0.30.40.8-0.9-0.7-0.3-0.40.40.90.70.60.6-0.6-0.60.60.80.6-0.60.60.50.20.7-0.6-0.2
Pavlov. Cond. intertrial magazine entries1.41.62.61.31.31.11.4-1.2-1.2-1.2-1.1-1.11.31.3-1.0-1.2-1.21.4-1.2-1.2-1.6-1.41.31.6
Pavlov. Cond. lever-magazine prob. diff.1.01.32.41.61.30.60.8-0.8-1.4-1.2-1.2-1.21.11.2-1.2-1.3-1.11.3-1.2-0.9-0.6-1.51.10.5
Pavlov. Cond. response bias1.11.32.21.51.30.81.0-0.9-1.4-1.3-1.2-1.11.21.2-1.1-1.3-1.11.2-1.1-1.0-0.7-1.41.10.6
Pavlov. Cond. lever latency1.62.12.6-1.4-1.4-1.5-1.41.51.41.41.61.6-1.4-1.41.61.41.4-1.51.51.41.51.5-1.3-1.5
Pavlov. Cond. magazine entry latency0.30.30.60.50.60.50.5-0.5-0.6-0.6-0.8-0.80.60.6-0.8-0.6-0.60.5-0.6-0.6-0.6-0.20.40.6
Pavlov. Cond. change in total contacts0.71.21.81.01.01.11.0-1.1-0.9-1.0-1.3-1.31.01.0-1.3-1.0-1.01.2-1.0-1.0-1.2-1.20.91.2
Pavlov. Cond. index score1.31.72.31.21.31.31.2-1.3-1.2-1.3-1.5-1.51.21.2-1.5-1.2-1.31.3-1.3-1.3-1.3-1.11.11.3
Pavlov. Cond. latency score1.31.72.41.21.31.31.2-1.3-1.3-1.3-1.6-1.61.31.2-1.5-1.2-1.21.2-1.3-1.3-1.4-1.11.11.4
Pavlov. Cond. lever contacts1.11.51.81.21.21.31.1-1.3-1.1-1.2-1.3-1.41.21.2-1.3-1.1-1.21.3-1.3-1.2-1.3-1.31.01.2
Pavlov. Cond. magazine entry number0.20.20.5-0.3-0.5-0.3-0.30.30.50.50.70.7-0.4-0.40.70.50.4-0.40.50.40.40.3-0.3-0.4
Pavlov. Cond. intertrial magazine entries3.55.26.1-2.3-2.4-2.2-2.32.22.42.42.42.4-2.3-2.32.52.32.3-2.12.32.32.22.0-2.1-2.2
Pavlov. Cond. lever-magazine prob. diff.0.81.11.61.01.11.00.9-1.0-1.0-1.0-1.3-1.31.01.0-1.3-1.0-1.01.1-1.1-1.0-1.0-0.90.91.0
Pavlov. Cond. response bias1.72.42.71.51.51.51.4-1.5-1.5-1.5-1.6-1.61.51.5-1.6-1.5-1.51.6-1.6-1.5-1.6-1.61.41.5
LgA PC1 addiction-like behavior0.00.10.30.60.30.1-0.1-0.1-0.4-0.2-0.2-0.10.10.1-0.1-0.2-0.00.3-0.2-0.10.2-0.4-0.0-0.3
Time in closed arm before self-admin0.60.81.5-1.1-1.0-0.7-0.80.81.11.00.80.8-0.9-0.90.71.00.8-1.20.80.90.31.2-0.8-0.2
Time in closed arm after self-admin1.01.02.2-1.5-1.3-0.8-0.80.71.41.11.00.9-1.1-1.00.81.20.9-1.30.91.00.41.4-0.8-0.5
Time in open arm before self-admin0.10.10.40.60.30.1-0.0-0.1-0.3-0.2-0.1-0.10.10.10.0-0.2-0.00.6-0.2-0.0-0.1-0.70.10.0
Time in open arm after self-admin1.21.32.41.51.20.80.9-0.9-1.4-1.2-1.1-1.01.21.2-1.0-1.3-1.11.4-1.1-1.0-0.9-1.41.21.0
Bone: periosteal estimation0.71.62.81.61.40.10.8-0.1-1.7-1.4-1.6-1.61.21.2-1.5-1.5-1.21.5-1.7-1.1-0.2-1.41.00.1
Bone: periosteal perimeter0.30.61.11.00.8-0.00.3-0.0-1.0-0.8-0.9-0.90.70.7-0.9-0.9-0.60.9-1.0-0.6-0.0-1.00.5-0.0
Bone: post-yield work1.11.72.70.91.21.61.4-1.6-1.1-1.2-1.3-1.31.31.2-1.3-1.1-1.30.9-1.1-1.4-1.6-1.11.21.6
Progressive ratio test 1 active lever presses1.72.13.61.51.41.71.9-1.6-1.1-1.4-1.5-1.41.41.5-1.4-1.3-1.61.3-1.5-1.2-1.4-0.91.51.4
Progressive ratio test 1 breakpoint1.72.13.61.51.41.71.9-1.6-1.1-1.4-1.5-1.41.41.5-1.4-1.3-1.61.3-1.5-1.2-1.4-1.01.51.4
Progressive ratio test 1 inactive lever presses3.34.87.02.12.22.42.7-2.5-2.0-2.2-2.1-2.12.32.3-2.1-2.1-2.41.5-2.1-2.3-2.3-1.32.32.4
Progressive ratio test 2 active lever presses0.50.61.70.40.61.21.3-1.1-0.3-0.6-0.8-0.70.70.7-0.6-0.4-0.80.1-0.6-0.9-0.90.00.70.7
Progressive ratio test 2 breakpoint0.40.41.40.30.51.11.2-1.0-0.2-0.5-0.7-0.60.60.6-0.5-0.3-0.7-0.0-0.5-0.8-0.80.10.60.6
Progressive ratio test 2 inactive lever presses1.52.53.81.31.61.82.0-2.0-1.4-1.6-1.6-1.61.61.6-1.6-1.5-1.70.8-1.6-1.7-1.8-0.51.61.7
ShA PR total presses1.82.12.51.51.51.41.4-1.4-1.5-1.5-1.6-1.51.51.5-1.4-1.5-1.51.5-1.6-1.5-1.3-1.41.41.3
Incentive Sensitization - Responses0.10.20.70.10.50.60.7-0.5-0.3-0.4-0.4-0.40.50.4-0.3-0.3-0.4-0.1-0.2-0.8-0.50.00.30.3
Incentive Sensitization - Breakpoint0.10.10.4-0.00.30.40.5-0.3-0.2-0.3-0.3-0.20.30.2-0.2-0.1-0.2-0.3-0.0-0.7-0.40.20.20.2
LgA PR total presses0.90.92.21.20.81.00.5-1.2-0.8-0.8-0.9-0.90.80.8-0.8-0.8-0.71.4-1.0-0.7-1.2-1.50.71.1
Sum of active levers in priming session hrs 5-60.40.31.21.10.5-0.4-0.10.4-0.8-0.6-0.4-0.40.40.5-0.4-0.7-0.41.0-0.5-0.1-0.1-1.10.40.1
Progressive ratio0.00.00.3-0.2-0.2-0.30.00.50.10.1-0.00.0-0.1-0.0-0.00.0-0.0-0.20.00.0-0.00.50.1-0.0
Food seeking constrained by brief footshock4.45.38.62.12.32.72.9-2.5-1.9-2.3-2.1-2.12.42.4-2.3-2.1-2.41.8-2.0-2.6-2.7-1.52.42.5
Seeking ratio, punishment vs. effort0.40.61.30.90.81.10.9-1.1-0.7-0.8-0.5-0.60.80.7-0.6-0.6-0.70.9-0.5-0.7-0.7-1.00.60.7
Retroperitoneal fat weight22.997.7115.2-9.8-10.3-10.7-10.510.39.710.09.69.6-10.0-9.99.69.69.7-9.99.510.09.99.7-9.4-9.7
Reaction time number correct0.40.71.11.00.90.90.7-0.8-1.0-0.9-0.9-0.90.80.8-0.9-0.9-0.81.0-0.7-0.8-0.7-0.90.70.7
Reaction time mean minus median0.00.10.50.00.00.40.3-0.50.1-0.0-0.00.00.10.10.10.0-0.1-0.3-0.1-0.2-0.70.30.10.6
Reaction time mean minus median AUC0.00.10.1-0.2-0.3-0.0-0.1-0.10.30.30.30.3-0.2-0.20.30.30.2-0.30.20.1-0.20.4-0.20.2
Reaction time num false alarms0.20.30.80.5-0.3-0.8-0.90.7-0.10.20.20.1-0.3-0.20.1-0.10.30.60.30.70.9-0.5-0.3-0.8
Reaction time num false alarms AUC0.20.31.00.6-0.2-0.9-1.00.8-0.10.20.10.1-0.3-0.20.1-0.10.30.80.30.80.9-0.6-0.3-0.7
Reaction time trials correct on left0.40.71.11.00.90.90.7-0.8-1.0-0.9-0.9-0.90.80.8-0.9-0.9-0.81.0-0.7-0.8-0.7-0.90.70.7
Reaction time trials on left0.40.81.21.11.00.90.7-0.9-1.0-0.9-0.9-0.90.90.9-0.9-0.9-0.81.1-0.7-0.9-0.7-1.00.80.7
Reaction time mean1.01.62.2-1.0-1.2-1.1-1.11.21.31.31.31.4-1.3-1.41.51.41.4-1.11.21.41.11.3-1.4-1.1
Reaction time mean AUC0.91.42.0-0.9-1.1-1.0-1.01.01.21.21.21.4-1.2-1.21.41.31.3-1.01.11.31.01.2-1.3-1.0
Median of all reaction times1.42.02.6-1.0-1.3-1.4-1.31.41.41.41.41.5-1.4-1.51.61.51.6-1.11.31.51.31.3-1.6-1.4
Reaction time omissions0.00.10.40.60.1-0.20.00.0-0.3-0.2-0.2-0.20.20.2-0.2-0.3-0.30.3-0.2-0.1-0.1-0.10.30.1
Reaction time false alarm rate0.40.61.60.1-0.7-1.2-1.31.10.30.60.60.5-0.7-0.60.50.40.70.20.71.21.2-0.1-0.7-1.1
Reaction time premature initiation rate0.10.20.3-0.4-0.5-0.1-0.30.10.50.40.40.4-0.4-0.40.50.50.3-0.50.40.4-0.10.4-0.4-0.0
Reaction time premature initiations0.00.00.10.10.10.40.1-0.4-0.0-0.1-0.1-0.10.10.1-0.0-0.0-0.10.10.0-0.1-0.4-0.10.10.3
Std. dev. reaction times0.20.40.7-0.5-0.6-0.4-0.40.50.70.60.60.7-0.6-0.60.80.70.6-0.70.60.60.40.8-0.7-0.5
Reaction time trials completed0.40.81.21.11.00.90.7-0.9-1.0-0.9-0.9-0.90.90.9-0.9-0.9-0.81.1-0.7-0.9-0.7-1.00.80.7
Reaction time trials AUC0.51.01.41.11.11.10.9-1.0-1.1-1.0-1.0-1.01.01.0-1.0-1.0-0.91.2-0.8-1.0-0.9-1.10.90.9
Run reversals in cocaine runway, females0.10.10.3-0.2-0.10.20.10.00.30.20.40.4-0.1-0.20.30.30.2-0.20.50.20.1-0.0-0.2-0.2
Run reversals in cocaine runway, males0.10.10.50.00.30.70.5-0.5-0.1-0.2-0.1-0.20.30.3-0.3-0.1-0.30.3-0.1-0.3-0.4-0.60.20.3
Latency to leave start box in cocaine runway0.60.61.10.70.90.61.0-0.3-0.7-0.8-0.9-0.90.90.8-0.8-0.7-0.80.7-0.8-1.1-0.8-0.40.80.7
Latency to leave start box in cocaine runway, F0.20.30.80.90.50.20.4-0.0-0.5-0.5-0.5-0.50.50.5-0.4-0.5-0.40.9-0.5-0.5-0.6-0.60.50.6
Latency to leave start box in cocaine runway, M0.20.20.7-0.40.40.60.8-0.4-0.1-0.4-0.4-0.40.40.4-0.4-0.2-0.4-0.5-0.4-0.8-0.30.50.40.1
Std. dev. time between licks in bursts0.20.31.2-0.1-0.4-1.1-1.00.90.10.40.40.4-0.5-0.50.50.20.6-0.30.20.60.80.1-0.6-0.7
Total sessions with >9 infusions1.11.42.90.51.01.51.7-1.5-0.7-1.0-1.2-1.31.21.2-1.3-0.9-1.30.3-1.1-1.4-1.3-0.21.41.3
Short access day 1 total inactive lever presses6.78.812.03.53.12.72.8-3.0-3.3-3.1-3.0-3.03.03.1-2.9-3.2-3.02.7-2.8-2.6-2.8-2.53.02.9
Short access day 10 total inactive lever presses1.74.14.92.22.02.01.8-2.2-2.1-2.0-1.9-1.92.02.0-1.9-2.1-2.02.1-1.8-1.7-2.2-2.02.02.1
Short access day 1 total infusions4.25.58.21.82.22.42.9-2.5-2.0-2.3-2.5-2.62.42.4-2.6-2.3-2.61.5-2.2-2.6-2.5-1.22.72.4
Short access day 10 total infusions2.22.94.61.61.71.92.1-1.8-1.5-1.7-1.8-1.71.71.7-1.7-1.6-1.81.3-1.5-1.6-1.7-1.31.81.7
Short access total infusions1.51.93.50.81.21.51.9-1.6-1.0-1.3-1.5-1.51.41.4-1.4-1.2-1.60.5-1.2-1.5-1.5-0.51.61.6
ShA early post infusion interval0.40.30.9-0.4-0.5-0.7-0.70.90.30.50.60.5-0.5-0.50.50.40.5-0.40.30.70.90.5-0.6-0.8
ShA late post infusion interval2.52.54.5-2.1-1.6-1.5-1.71.31.61.61.51.4-1.6-1.61.61.61.6-1.81.21.41.11.9-1.7-1.1
ShA early loading0.20.20.60.60.3-0.10.2-0.1-0.4-0.3-0.4-0.30.30.3-0.4-0.5-0.40.8-0.50.0-0.0-0.80.40.1
ShA late loading0.60.81.61.00.90.60.7-0.8-1.0-0.9-1.0-1.00.90.9-0.9-1.0-0.91.3-1.0-0.9-0.5-1.10.90.6
Short access day 1 locomotion3.54.37.81.41.92.52.5-2.8-1.6-1.9-2.1-2.22.12.1-2.1-1.8-2.21.3-1.9-2.3-2.3-1.12.32.3
Short access day 10 total locomotion1.42.55.51.61.52.01.6-2.3-1.4-1.5-1.5-1.41.51.5-1.3-1.5-1.61.5-1.5-1.3-1.9-1.21.52.0
Short access total locomotion0.40.51.60.10.51.11.0-1.3-0.2-0.5-0.7-0.60.60.6-0.6-0.4-0.80.2-0.5-0.6-0.90.10.71.0
ShA early average infusions1.41.72.41.31.21.11.5-1.2-1.1-1.2-1.5-1.51.21.3-1.5-1.2-1.41.3-1.3-1.1-1.2-1.11.51.2
ShA late average infusions2.32.43.31.61.51.21.7-1.3-1.5-1.6-1.8-1.81.61.6-1.8-1.6-1.71.3-1.6-1.6-1.4-1.11.71.4
ShA early timeout0.40.40.70.60.60.40.7-0.5-0.6-0.6-0.8-0.80.60.6-0.7-0.6-0.60.7-0.8-0.4-0.6-0.50.70.5
ShA late timeout2.02.23.11.31.41.31.7-1.4-1.3-1.4-1.6-1.61.51.5-1.7-1.4-1.61.1-1.4-1.5-1.6-1.11.61.5
ShA early titration0.20.20.40.50.40.40.5-0.6-0.4-0.4-0.6-0.60.40.4-0.6-0.4-0.50.5-0.4-0.2-0.6-0.40.50.5
ShA late titration1.81.92.61.41.51.01.4-1.0-1.5-1.5-1.6-1.61.41.4-1.6-1.5-1.51.2-1.5-1.5-1.0-1.11.51.0
ShA total infusions0.91.11.61.31.10.81.1-0.9-1.1-1.1-1.2-1.21.11.1-1.2-1.1-1.21.0-1.1-1.1-0.9-0.81.20.9
One hour access (0.3 mA shock)1.41.62.81.01.31.71.6-1.5-1.1-1.2-1.2-1.21.31.2-1.2-1.1-1.20.7-1.4-1.4-1.5-0.71.21.3
Shock compulsivity0.51.01.91.31.21.31.0-1.1-1.0-1.0-1.1-1.01.00.9-0.9-0.9-0.81.4-1.0-0.8-1.0-1.00.60.8
Compulsive drug intake1.41.63.2-0.8-1.1-1.7-1.81.70.81.11.51.3-1.2-1.21.21.01.4-0.61.41.41.50.2-1.3-1.4
One hour access (shock baseline)2.03.15.31.41.82.32.3-2.3-1.4-1.7-1.9-1.71.81.7-1.6-1.5-1.81.3-1.9-2.0-2.0-0.91.71.7
Social response proportion0.30.41.2-0.6-0.5-0.5-0.30.80.60.50.40.4-0.5-0.50.50.60.5-0.70.20.51.10.9-0.5-1.1
Social responses0.20.20.7-0.1-0.3-0.5-0.50.60.30.30.20.3-0.4-0.40.40.30.3-0.4-0.10.40.80.7-0.4-0.8
Social time0.30.42.0-0.7-0.6-0.4-0.40.40.70.60.40.5-0.5-0.60.40.60.5-1.10.50.30.41.4-0.5-0.5
Soleus weight4.413.016.54.03.83.33.4-3.3-3.8-3.7-3.6-3.73.63.6-3.6-3.6-3.43.9-3.7-3.4-3.5-4.13.23.5
Bone: stiffness0.00.00.00.10.10.2-0.1-0.2-0.2-0.1-0.1-0.10.10.1-0.1-0.10.00.2-0.2-0.2-0.1-0.1-0.00.1
Tibialis anterior weight3.612.014.23.73.53.13.1-3.3-3.6-3.5-3.6-3.63.43.5-3.5-3.6-3.43.7-3.7-3.3-3.3-3.83.23.3
Time to tail flick, vehicle, before self-admin0.80.81.8-1.2-1.0-0.3-0.40.21.31.00.90.9-0.9-0.90.81.10.7-1.21.20.70.41.3-0.6-0.5
Time to tail flick, vehicle, after self-admin3.14.15.7-2.4-2.2-1.8-1.81.92.42.21.81.8-2.1-2.11.82.21.9-2.12.22.01.82.2-2.0-1.8
Time to tail flick, test, before self-admin0.10.10.20.10.20.40.4-0.5-0.1-0.3-0.3-0.30.30.3-0.2-0.2-0.40.4-0.2-0.2-0.4-0.30.40.5
Time to tail flick, test, after self-admin0.20.20.60.50.40.80.6-0.3-0.2-0.4-0.3-0.30.40.3-0.4-0.2-0.40.4-0.3-0.3-0.6-0.20.30.5
Delta time to tail flick, vehicle, before/after SA0.10.10.7-0.4-0.3-0.7-0.40.80.20.30.10.1-0.3-0.30.10.20.2-0.20.20.40.40.2-0.3-0.4
Delta time to tail flick, test, before/after SA1.41.52.41.61.41.31.1-0.9-1.3-1.3-1.1-1.21.21.2-1.2-1.2-1.11.3-1.3-1.2-1.2-1.21.01.1
Tibia length2.97.910.2-2.8-2.7-2.9-2.72.92.72.72.72.7-2.8-2.82.82.72.8-2.82.72.73.22.9-2.7-3.2
Ambulatory time before self-admin0.00.00.10.10.20.20.0-0.3-0.1-0.1-0.10.00.0-0.00.10.00.10.1-0.0-0.0-0.1-0.2-0.20.0
Ambulatory time after self-admin1.51.82.2-1.5-1.2-1.4-1.51.41.01.31.41.4-1.3-1.41.41.21.5-1.41.41.21.31.2-1.4-1.3
Bone: tissue strength0.90.91.2-1.0-0.9-0.7-0.80.71.01.01.11.1-0.9-1.01.11.01.0-0.81.10.90.90.6-0.9-0.9
Total heroin consumption2.83.35.52.01.81.71.5-1.7-1.9-1.8-1.9-1.81.81.8-1.8-1.8-1.72.3-1.8-1.6-1.7-2.21.71.7
Total infusions0.10.10.30.1-0.3-0.5-0.40.40.30.30.10.2-0.4-0.40.30.30.4-0.30.20.40.50.5-0.4-0.5
Bone: trabecular number2.94.77.32.72.51.41.9-1.3-2.6-2.4-2.3-2.32.22.2-2.3-2.4-2.22.7-2.3-2.0-1.3-2.52.01.2
Bone: trabecular spacing2.73.54.8-2.2-2.0-1.2-1.71.22.22.02.12.2-1.9-1.92.22.12.0-2.22.21.81.11.8-1.7-1.0
Bone: trabecular thickness0.60.71.21.11.0-0.00.60.0-1.1-0.9-1.0-1.10.90.9-1.1-1.0-0.91.1-1.0-0.70.0-0.80.7-0.0
Bone: trabecular tissue density0.30.50.80.50.70.90.6-0.9-0.8-0.7-0.5-0.50.70.7-0.5-0.7-0.60.6-0.7-0.8-0.8-0.50.60.8
Water consumed over 24 hours0.30.41.31.10.70.10.1-0.2-1.0-0.7-0.7-0.70.50.6-0.6-0.8-0.51.1-0.9-0.4-0.3-0.80.40.3
Number of responses in last shaping day0.30.40.8-0.40.50.50.9-0.5-0.3-0.5-0.8-0.80.60.5-0.7-0.4-0.7-0.4-0.9-0.9-0.30.30.70.3