Hub : Genes

Atraid

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IL mRNA stability Atraid 0.23 0.19 5.8e-04 0.16 0.1 0.14 0.13 1.5e-04 2.0e-03 2.9e-04 5.8e-04
2 BLA mRNA stability Atraid 0.25 0.28 9.8e-04 0.05 0.05 0.03 0.04 1.8e-03 1.9e-03 6.2e-03 3.4e-03
3 Brain mRNA stability Atraid 0.07 0.05 3.8e-08 0.06 0.08 0.06 0.07 3.1e-06 1.1e-07 4.5e-06 7.3e-07
4 LHb gene expression Atraid 0.48 0.38 2.8e-05 0.22 0.15 0.17 0.19 7.1e-06 1.8e-04 8.3e-05 2.5e-05
5 pVTA intron excision ratio chr6_31037182_31038877 0.13 0.09 2.2e-05 0.05 0.06 0.06 0.06 6.9e-05 6.8e-06 2.2e-05 1.2e-05
6 Liver gene expression Atraid 0.33 0.19 0.0e+00 0.26 0.26 0.26 0.26 3.2e-28 3.9e-28 3.0e-28 3.0e-28
7 Adipose gene expression Atraid 0.22 0.16 0.0e+00 0.16 0.16 0.16 0.16 5.4e-17 6.1e-18 8.2e-18 6.8e-18
8 PL gene expression Atraid 0.45 0.08 5.6e-17 0.17 0.15 0.16 0.16 7.0e-18 3.6e-16 1.3e-16 3.8e-17
9 Adipose mRNA stability Atraid 0.04 0.04 9.4e-04 0.02 0.02 0.02 0.02 4.4e-03 3.6e-03 3.1e-03 4.8e-03
10 NAcc mRNA stability Atraid 0.04 0.03 2.3e-07 0.04 0.04 0.04 0.04 1.9e-06 3.6e-07 1.1e-06 6.7e-07
11 PL mRNA stability Atraid 0.05 0.05 1.2e-05 0.04 0.05 0.04 0.04 3.0e-05 8.3e-06 1.3e-05 1.3e-05
12 OFC mRNA stability Atraid 0.42 0.38 1.4e-04 0.17 0.14 0.14 0.15 8.6e-05 3.7e-04 3.8e-04 2.0e-04
13 RMTg gene expression Atraid 0.21 0.12 2.2e-06 0.19 0.2 0.17 0.2 7.3e-06 5.0e-06 2.4e-05 5.3e-06
14 pVTA gene expression Atraid 0.17 0.1 4.1e-13 0.17 0.17 0.15 0.17 1.2e-13 5.7e-14 3.5e-12 7.0e-14
15 Brain gene expression Atraid 0.52 0.21 0.0e+00 0.22 0.2 0.22 0.21 2.9e-20 4.9e-18 4.1e-20 1.1e-19
16 PL intron excision ratio chr6_31037182_31038552 0.03 0.03 1.8e-03 0.03 0.03 0.03 0.03 1.7e-04 8.7e-04 2.8e-04 2.7e-04
17 IC gene expression Atraid 0.28 0.23 4.6e-03 0.03 0.04 0.02 0.02 2.2e-02 1.4e-02 3.7e-02 6.5e-02
18 NAcc gene expression Atraid 0.21 0.37 5.6e-14 0.1 0.09 0.1 0.1 3.9e-15 3.1e-13 1.7e-14 6.2e-15
19 BLA gene expression Atraid 0.16 0.16 5.5e-06 0.12 0.09 0.11 0.11 1.0e-06 1.2e-05 1.4e-06 3.0e-06
20 PL intron excision ratio chr6_31037182_31038877 0.03 0.03 8.0e-04 0.03 0.03 0.03 0.03 1.9e-04 3.6e-04 1.6e-04 2.0e-04
21 pVTA mRNA stability Atraid 0.17 0.11 1.1e-09 0.12 0.12 0.11 0.12 5.0e-10 4.6e-10 4.6e-09 3.3e-10

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
Bone: apparent density3.96.79.51.93.12.8-1.92.2-3.0-2.8-2.8-2.82.62.63.1-2.9-2.6-2.8-1.9-2.4-2.7-2.91.92.3
Area under the delay curve0.10.21.2-0.30.60.30.20.1-0.2-0.2-0.4-0.40.20.20.9-0.2-0.1-0.20.1-0.0-0.4-1.1-0.20.1
BMI with tail0.41.33.4-1.8-1.0-1.31.4-1.60.91.11.11.1-1.2-1.1-0.80.91.11.11.01.30.90.9-0.9-1.0
BMI without tail0.82.44.5-2.1-1.5-1.61.9-1.81.41.51.41.5-1.5-1.5-1.51.41.51.61.41.41.21.5-1.3-1.4
Body weight2.410.413.8-3.7-3.3-3.33.5-3.43.13.33.13.2-3.3-3.3-3.03.23.33.23.33.22.82.8-3.3-3.2
Weight adjusted by age0.10.20.60.70.20.3-0.70.6-0.2-0.3-0.5-0.50.40.5-0.1-0.4-0.6-0.5-0.5-0.4-0.40.30.50.6
Bone surface1.93.45.70.82.32.1-0.91.2-2.4-2.0-2.2-2.21.81.82.4-2.2-1.8-2.2-0.9-1.6-2.2-2.10.81.4
Bone volume1.93.55.70.92.42.1-0.91.4-2.4-2.1-2.1-2.11.91.92.3-2.2-1.8-2.2-0.9-1.6-2.1-2.10.81.5
Breakpoint value in progressive ratio session0.91.01.80.60.90.9-0.51.1-0.8-1.0-1.2-1.21.01.01.3-1.0-1.1-1.2-0.8-0.9-1.1-1.30.81.2
Number of licking bursts0.10.10.7-0.80.4-0.00.6-0.6-0.30.0-0.1-0.1-0.2-0.10.6-0.20.2-0.10.40.4-0.2-0.4-0.3-0.2
Context. condit. distance diff. score0.00.00.10.3-0.20.1-0.30.2-0.0-0.1-0.0-0.00.10.1-0.0-0.0-0.00.0-0.3-0.1-0.1-0.00.30.0
Locomotion velocity, session 10.20.20.8-0.9-0.2-0.10.8-0.4-0.00.20.30.3-0.2-0.2-0.20.10.30.20.90.30.20.3-0.9-0.3
Locomotion distance, session 11.11.42.70.31.51.5-0.40.8-1.7-1.4-1.3-1.31.21.21.5-1.5-1.1-1.3-0.3-1.0-1.2-1.60.30.8
Locomotion velocity, session 20.30.30.5-0.6-0.6-0.50.6-0.70.50.60.60.6-0.6-0.6-0.50.60.70.70.40.60.60.3-0.4-0.7
Locomotion distance, session 20.00.00.2-0.5-0.00.00.5-0.2-0.10.00.10.0-0.1-0.1-0.1-0.00.10.00.30.10.2-0.0-0.3-0.2
Locomotion velocity, session 30.91.01.71.30.70.9-1.31.1-0.8-1.0-0.9-1.01.01.10.7-1.0-1.2-1.0-1.2-1.1-0.8-0.71.21.3
Locomotion distance, session 30.60.61.00.50.90.9-0.40.6-1.0-0.9-0.9-0.90.80.91.0-1.0-0.8-0.8-0.5-0.8-0.7-0.90.40.8
Stereotopy head waving bouts, day 32.42.83.61.91.41.6-1.91.8-1.5-1.6-1.6-1.61.71.71.3-1.6-1.8-1.6-1.9-1.8-1.7-1.31.91.8
Stereotopy head waving duration, day 30.30.40.70.80.20.4-0.80.8-0.3-0.5-0.5-0.50.60.60.2-0.5-0.7-0.5-0.8-0.7-0.5-0.30.90.8
Locomotion velocity, session 70.91.01.60.31.31.0-0.30.7-1.2-1.1-1.3-1.21.01.10.9-1.2-1.1-1.2-0.3-0.9-1.2-0.90.31.0
Locomotion distance, session 70.10.20.9-0.90.10.11.0-0.3-0.3-0.1-0.4-0.40.00.1-0.1-0.3-0.1-0.40.80.0-0.30.0-0.7-0.0
Stereotopy head waving bouts, day 70.00.10.20.50.30.1-0.5-0.1-0.1-0.10.10.10.10.10.2-0.1-0.10.1-0.4-0.1-0.1-0.20.50.1
Stereotopy head waving duration, day 70.60.72.01.40.70.6-1.40.8-0.5-0.7-0.5-0.50.70.70.6-0.6-0.7-0.5-1.2-0.8-0.7-0.61.20.8
Locomotion velocity, session 80.30.30.50.60.30.6-0.60.7-0.5-0.6-0.7-0.60.60.60.1-0.5-0.6-0.6-0.5-0.7-0.6-0.10.50.5
Locomotion distance, session 80.20.30.50.40.50.7-0.30.4-0.7-0.6-0.6-0.60.60.50.5-0.6-0.5-0.6-0.4-0.5-0.6-0.70.40.3
Degree of sensitization distance1.01.02.0-1.4-0.9-1.01.3-1.20.91.00.80.8-1.0-1.0-1.00.91.00.81.21.00.71.0-1.2-1.1
Degree of sensitization stereotypy0.20.20.50.0-0.2-0.5-0.0-0.60.50.50.70.7-0.5-0.5-0.30.50.50.70.00.50.50.20.1-0.4
Conditioned locomotion3.43.95.12.21.92.0-2.22.1-1.8-1.9-1.9-1.92.01.91.7-1.8-1.9-1.8-2.2-2.0-1.8-1.92.21.9
Cocaine response after cond. corrected0.40.51.40.10.90.8-0.10.4-0.9-0.8-0.8-0.90.70.70.9-0.8-0.6-0.9-0.1-0.5-0.9-1.20.10.5
Cocaine response after cond. not corrected1.21.42.80.81.61.3-0.80.9-1.4-1.3-1.2-1.21.21.11.5-1.3-1.1-1.2-0.8-0.9-1.3-1.70.80.9
Cocaine response before conditioning1.92.34.32.01.61.5-2.11.6-1.3-1.4-1.1-1.11.51.41.3-1.3-1.4-1.1-2.1-1.5-1.2-1.12.11.3
Saline control response0.81.12.21.40.91.0-1.41.0-0.9-1.0-0.9-0.91.01.00.7-0.9-1.0-0.9-1.4-1.1-0.9-0.71.50.9
Bone: connectivity density3.75.88.51.72.82.6-1.72.0-2.8-2.6-2.6-2.62.42.52.9-2.7-2.4-2.6-1.8-2.2-2.6-2.81.72.3
Bone: cortical apparent density0.30.51.00.31.00.7-0.40.4-0.8-0.7-0.7-0.70.60.61.0-0.8-0.6-0.8-0.4-0.5-0.7-1.00.40.5
Bone: cortical area0.40.61.3-0.21.00.90.10.2-1.2-0.8-0.9-0.90.70.71.1-1.0-0.6-0.90.1-0.5-1.0-1.0-0.10.4
Bone: cortical porosity1.61.73.31.81.21.3-1.81.5-1.1-1.2-1.0-1.01.31.21.2-1.1-1.2-1.0-1.7-1.4-1.0-0.91.61.3
Bone: cortical porosity1.51.62.31.51.21.3-1.51.5-1.2-1.3-1.1-1.11.31.31.3-1.2-1.3-1.1-1.4-1.4-1.1-0.91.31.3
Bone: cortical thickness0.10.10.4-0.60.1-0.10.5-0.7-0.20.10.20.2-0.3-0.30.20.00.40.20.60.40.2-0.2-0.5-0.5
Bone: cortical thickness1.11.31.90.51.31.3-0.60.9-1.4-1.2-1.3-1.41.21.21.4-1.3-1.1-1.4-0.6-1.1-1.2-1.40.61.1
Bone: cortical tissue density0.20.30.70.20.90.6-0.20.3-0.7-0.6-0.6-0.60.50.50.8-0.6-0.4-0.6-0.3-0.3-0.5-0.80.30.4
Condit. Reinf. active minus inactive responses0.91.01.9-1.3-0.7-1.01.4-1.20.81.00.80.8-1.0-1.0-0.70.81.00.81.31.20.90.6-1.3-0.9
Condit. Reinf. active-inactive response ratio1.01.02.3-1.4-0.8-1.01.5-1.00.91.00.80.8-1.0-0.9-0.70.90.90.81.41.10.90.7-1.4-0.8
Condit. Reinf. active responses0.10.10.5-0.20.60.30.2-0.1-0.4-0.3-0.3-0.20.20.20.6-0.3-0.1-0.20.10.0-0.3-0.7-0.10.1
Condit. Reinf. inactive responses1.41.72.61.11.61.4-1.11.0-1.5-1.4-1.2-1.11.31.31.5-1.4-1.2-1.2-1.3-1.2-1.4-1.61.31.1
Incentive salience index mean0.10.10.4-0.60.3-0.00.6-0.3-0.10.0-0.2-0.1-0.1-0.10.3-0.10.1-0.10.50.30.0-0.3-0.6-0.1
Condit. Reinf. lever presses0.50.71.40.31.20.9-0.40.7-1.0-0.9-0.9-0.90.80.81.1-0.9-0.8-0.9-0.5-0.6-0.8-1.20.40.7
Condit. Reinf. active minus inactive responses4.35.68.82.92.02.2-3.02.4-2.1-2.2-2.1-2.12.32.32.2-2.2-2.3-2.0-2.9-2.3-2.0-2.32.92.4
Condit. Reinf. active-inactive response ratio1.61.85.02.20.91.1-2.21.2-1.0-1.1-0.8-0.81.21.21.1-1.0-1.1-0.8-2.2-1.2-0.9-1.12.21.2
Condit. Reinf. active responses3.44.75.52.32.12.0-2.32.2-2.0-2.1-2.1-2.12.22.22.1-2.1-2.3-2.0-2.3-2.1-2.0-2.22.32.3
Condit. Reinf. inactive responses1.31.72.50.51.51.3-0.51.3-1.4-1.4-1.6-1.61.41.41.5-1.4-1.5-1.5-0.5-1.2-1.5-1.50.51.4
Condit. Reinf. lever presses2.13.03.81.91.61.7-2.01.7-1.6-1.7-1.8-1.71.71.71.7-1.6-1.6-1.7-1.9-1.7-1.6-1.91.91.5
Condit. Reinf. lever reinforcers received3.24.45.62.32.02.0-2.42.1-1.9-2.0-2.0-2.02.12.12.0-2.0-2.2-1.9-2.3-2.1-1.9-2.12.32.2
Conditioned reinforcement - actives1.83.26.32.30.91.6-2.32.5-1.1-1.6-1.8-1.81.81.70.6-1.3-1.9-1.8-2.2-2.3-1.7-0.42.01.9
Conditioned reinforcement - inactives2.94.36.62.02.62.2-2.32.2-2.1-2.1-2.0-2.02.12.12.1-2.1-2.1-1.9-2.1-1.7-2.1-1.72.12.0
Conditioned locomotion0.71.02.41.3-0.20.5-1.41.6-0.1-0.6-1.0-0.90.80.8-0.6-0.4-1.0-0.8-1.3-1.4-0.71.01.21.0
Patch foraging indifference point 0 sec0.40.71.1-0.9-0.6-1.00.8-0.90.80.91.00.9-0.9-0.8-0.60.70.70.80.80.91.10.9-0.8-0.7
Patch foraging indifference point AUC0.81.22.60.21.41.3-0.30.6-1.6-1.3-1.3-1.21.11.11.4-1.4-1.0-1.2-0.6-1.2-1.2-1.10.50.9
Delay disc. indifference point, 0s delay3.33.65.5-2.3-1.5-1.82.4-1.91.91.91.81.8-2.0-2.0-1.32.02.11.82.12.11.71.1-2.2-2.2
Delay disc. indifference point, 16s delay0.10.11.00.00.40.2-0.30.1-0.2-0.2-0.2-0.10.20.20.7-0.2-0.1-0.0-0.2-0.1-0.2-1.00.10.2
Delay disc. indifference point, 2s delay0.20.20.5-0.5-0.3-0.40.7-0.50.40.40.40.3-0.5-0.5-0.20.40.50.40.70.50.20.2-0.7-0.6
Delay disc. indifference point, 24s delay1.01.15.20.81.41.0-1.01.0-0.9-0.9-1.0-1.10.90.91.8-0.8-0.8-0.9-0.4-0.7-0.9-2.30.30.8
Delay disc. indifference point, 4s delay0.10.10.4-0.60.30.00.6-0.2-0.1-0.0-0.1-0.1-0.0-0.00.2-0.10.0-0.00.20.1-0.2-0.3-0.2-0.1
Delay disc. indifference point, 8s delay0.10.10.8-0.00.40.2-0.00.2-0.1-0.1-0.3-0.30.10.10.8-0.1-0.1-0.20.0-0.0-0.2-0.9-0.10.0
Indifference point function ln k0.10.10.80.9-0.00.2-0.70.70.0-0.2-0.2-0.20.30.2-0.0-0.1-0.3-0.3-0.5-0.3-0.3-0.00.40.3
Indifference point function log k0.10.10.80.9-0.00.2-0.70.70.0-0.2-0.2-0.20.30.2-0.0-0.1-0.3-0.3-0.5-0.3-0.3-0.00.40.3
Patch foraging total patch changes 0 sec0.30.61.0-0.9-0.5-0.90.8-1.00.80.90.90.8-0.8-0.8-0.50.70.70.70.70.91.00.8-0.6-0.7
Patch foraging total patch changes 12 sec1.11.52.3-1.5-1.0-1.31.4-1.41.11.21.31.3-1.2-1.2-1.01.11.21.21.11.21.41.3-1.1-1.2
Patch foraging total patch changes 18 sec0.10.20.8-0.9-0.1-0.40.7-0.80.20.40.30.2-0.4-0.4-0.30.20.40.20.60.30.40.6-0.5-0.4
Patch foraging total patch changes 24 sec0.71.22.6-1.1-1.2-1.20.9-1.21.01.11.11.1-1.1-1.1-1.31.01.11.00.61.01.31.6-0.6-1.1
Patch foraging total patch changes 6 sec0.20.31.0-1.0-0.1-0.60.9-0.80.30.50.50.5-0.5-0.4-0.10.30.40.50.80.50.80.5-0.8-0.3
Patch foraging time to switch 0 sec0.00.00.1-0.1-0.2-0.30.1-0.30.30.20.20.2-0.2-0.1-0.20.10.10.20.10.3-0.0-0.20.00.0
Patch foraging water rate 0 sec0.10.10.50.70.00.3-0.60.6-0.1-0.2-0.2-0.30.30.20.0-0.1-0.2-0.3-0.7-0.5-0.00.30.50.1
Patch foraging water rate 12 sec0.81.62.4-0.6-1.6-1.30.7-0.91.61.31.41.3-1.3-1.3-1.61.51.31.20.71.01.51.6-0.8-1.3
Patch foraging water rate 18 sec0.40.51.10.4-1.0-0.7-0.1-0.11.00.71.01.0-0.6-0.7-1.01.00.70.90.20.50.71.0-0.3-0.7
Patch foraging water rate 24 sec1.62.33.9-0.9-2.0-1.70.9-1.12.01.71.51.5-1.6-1.6-1.91.91.51.40.91.21.71.6-1.0-1.4
Patch foraging water rate 6 sec0.91.42.0-0.5-1.4-1.10.7-0.71.41.21.41.4-1.1-1.2-1.41.41.31.40.70.91.21.4-0.8-1.3
Seeking ratio, delayed vs. immediate footshock0.10.10.7-0.0-0.3-0.10.1-0.00.10.10.20.2-0.1-0.1-0.70.1-0.00.10.0-0.10.00.80.0-0.1
Distance traveled before self-admin0.00.00.10.1-0.00.0-0.0-0.10.00.10.10.2-0.1-0.2-0.10.20.30.20.20.10.10.0-0.3-0.4
Distance traveled after self-admin2.32.83.4-1.7-1.7-1.51.8-1.81.41.61.61.7-1.7-1.7-1.61.61.81.61.81.51.61.4-1.8-1.8
Extensor digitorum longus weight4.517.618.74.14.34.2-4.24.0-4.2-4.2-4.2-4.24.24.24.3-4.2-4.1-4.1-4.3-4.2-4.3-4.34.34.0
Bone: elastic displacement0.80.91.60.90.80.9-0.91.3-0.7-0.9-1.0-1.00.90.90.9-0.8-1.0-1.1-1.0-0.9-0.7-0.90.91.0
Bone: elastic work0.81.11.60.61.11.1-0.61.1-1.1-1.1-1.2-1.21.01.11.2-1.1-1.1-1.2-0.7-1.0-1.1-1.20.61.0
Bone: endosteal estimation0.51.22.20.01.21.2-0.00.8-1.3-1.1-1.4-1.41.01.11.2-1.3-1.1-1.4-0.1-1.0-1.5-1.10.11.0
Bone: endosteal perimeter0.20.51.1-0.20.80.70.20.4-0.8-0.7-0.9-0.90.60.60.7-0.8-0.7-0.90.1-0.6-1.0-0.8-0.20.5
Epididymis fat weight16.054.962.3-7.7-7.9-7.97.5-7.37.87.77.27.2-7.6-7.5-7.57.57.37.17.07.37.27.4-6.9-7.0
Delta time in closed arm before/after self-admin0.00.00.2-0.2-0.2-0.0-0.1-0.2-0.1-0.0-0.2-0.20.00.00.1-0.1-0.1-0.20.0-0.0-0.4-0.2-0.10.1
Delta time in open arm before/after self-admin0.10.10.20.20.40.3-0.30.4-0.3-0.4-0.4-0.30.40.40.3-0.4-0.5-0.4-0.3-0.4-0.3-0.30.40.5
Diff in mean of infusions in LGA sessions0.00.00.2-0.20.30.10.20.1-0.1-0.1-0.2-0.20.10.10.3-0.2-0.2-0.4-0.1-0.1-0.0-0.10.20.2
Delay discount exponential model param0.30.42.0-0.1-0.9-0.60.1-0.50.50.50.70.7-0.5-0.5-1.10.50.50.60.20.40.71.4-0.1-0.4
Extinction: sum of active levers before priming0.30.41.00.30.70.5-0.50.4-0.5-0.5-0.6-0.60.50.60.9-0.6-0.5-0.6-0.7-0.4-0.5-1.00.80.5
Active lever presses in extinction session 60.90.91.90.90.50.8-0.71.4-0.6-0.9-1.1-1.01.01.00.3-0.8-1.1-1.0-1.1-1.2-0.8-0.11.01.3
Bone: final force0.10.10.3-0.40.20.30.30.0-0.5-0.3-0.6-0.50.20.20.3-0.4-0.2-0.50.3-0.2-0.5-0.3-0.40.1
Bone: final moment0.10.20.3-0.40.30.40.40.0-0.6-0.4-0.6-0.50.30.30.4-0.5-0.3-0.50.4-0.3-0.5-0.4-0.40.2
Food consumed during 24 hour testing period0.10.10.30.30.50.4-0.30.2-0.6-0.4-0.3-0.30.40.40.5-0.5-0.3-0.3-0.3-0.3-0.4-0.40.40.3
Glucose0.20.40.8-0.7-0.6-0.60.5-0.70.50.60.50.5-0.6-0.6-0.70.50.60.50.60.60.50.9-0.7-0.7
Heart weight3.35.16.2-2.3-2.0-2.12.2-2.42.02.22.42.5-2.2-2.3-2.22.12.42.52.22.32.02.2-2.2-2.4
Delay discount hyperbolic model param0.20.21.30.1-0.7-0.4-0.1-0.30.40.40.50.5-0.3-0.4-0.90.40.30.40.00.20.61.20.1-0.3
Intermittent access intake day 1-15 change0.10.21.00.60.00.4-0.70.5-0.2-0.3-0.4-0.40.40.3-0.1-0.1-0.2-0.3-0.8-1.0-0.40.30.50.3
Intermittent access intake escalation0.00.10.40.3-0.20.1-0.40.10.1-0.0-0.1-0.00.0-0.0-0.20.20.10.0-0.4-0.6-0.10.50.2-0.0
Intermittent access intake escalation 20.00.00.30.1-0.00.1-0.3-0.2-0.1-0.00.10.20.0-0.1-0.30.00.20.2-0.2-0.4-0.20.5-0.0-0.1
Intermitt. access day 1 inactive lever presses0.51.93.21.61.21.3-1.81.5-1.3-1.3-1.2-1.31.41.41.1-1.4-1.4-1.3-1.7-1.2-1.2-0.81.81.4
Intermitt. access day 15 inactive lever presses3.26.59.52.12.72.8-2.42.3-3.1-2.8-2.5-2.52.72.72.0-3.0-2.7-2.5-2.4-2.5-2.6-1.92.52.6
Intermitt. access escalation Index0.70.92.7-1.6-0.8-0.91.5-1.60.40.80.90.8-0.8-0.8-0.90.50.90.81.10.81.00.8-0.9-0.7
Intermittent access day 1 total infusions3.35.36.62.52.32.3-2.42.6-2.2-2.3-2.3-2.32.42.41.9-2.3-2.5-2.2-2.4-2.1-2.0-2.02.42.4
Intermittent access day 15 total infusions1.52.33.11.81.31.6-1.71.7-1.4-1.6-1.5-1.51.61.51.0-1.4-1.5-1.4-1.7-1.8-1.3-1.01.61.5
Intermittent access terminal intake (last 3 days)2.53.34.72.11.51.9-2.12.0-1.7-1.8-1.8-1.71.91.81.3-1.7-1.8-1.6-2.2-2.0-1.6-1.22.01.8
Intermittent access total infusions2.83.35.32.31.51.7-2.22.3-1.4-1.7-1.9-1.81.81.81.3-1.6-1.9-1.7-2.2-1.9-1.6-1.22.01.9
Intermittent access day 1 locomotion2.02.64.01.71.41.5-1.91.8-1.4-1.6-1.6-1.51.61.61.5-1.5-1.7-1.4-1.9-1.4-1.3-1.42.01.6
Intermittent access day 15 total locomotion0.30.51.30.80.70.6-1.10.8-0.5-0.6-0.9-0.70.60.70.5-0.6-0.7-0.6-1.1-0.6-0.7-0.11.10.7
Intermittent access total locomotion0.70.82.11.10.60.6-1.41.2-0.3-0.7-1.1-0.90.80.80.4-0.6-1.0-0.8-1.4-0.8-0.7-0.11.40.9
Intermittent access standard deviation0.81.72.31.41.31.3-1.51.4-1.2-1.3-1.3-1.31.31.31.1-1.3-1.4-1.3-1.4-1.3-1.2-0.91.31.3
Left kidney weight0.00.00.1-0.1-0.3-0.20.3-0.10.30.20.10.2-0.2-0.2-0.20.20.10.10.40.10.1-0.0-0.3-0.1
Right kidney weight0.52.22.9-1.5-1.2-1.51.5-1.51.51.51.61.6-1.5-1.5-0.81.51.61.61.61.71.30.7-1.6-1.5
Cocaine induced anxiety0.20.30.50.20.60.5-0.70.3-0.6-0.5-0.5-0.50.50.50.4-0.6-0.5-0.5-0.3-0.5-0.5-0.30.50.5
Post-drug Anxiety1.41.52.4-1.5-0.9-1.21.3-1.41.11.21.21.2-1.2-1.2-0.91.11.31.21.51.31.21.1-1.4-1.3
Baseline Anxiety3.43.96.4-2.1-1.9-2.02.5-1.92.02.01.91.9-2.0-2.0-1.62.01.91.92.02.12.11.7-2.1-2.0
Tail length0.41.72.4-1.2-1.4-1.21.5-1.11.41.31.21.3-1.2-1.3-1.51.41.31.41.51.01.01.4-1.5-1.3
Length with tail1.77.610.1-2.4-3.2-2.82.6-2.33.02.82.72.7-2.7-2.8-3.03.02.82.72.82.42.52.8-2.9-2.7
Length without tail0.62.02.8-1.4-1.7-1.41.4-1.21.51.41.31.3-1.4-1.4-1.51.51.41.21.61.41.21.3-1.7-1.4
Times rat made contact with spout1.82.03.21.31.61.4-1.31.2-1.5-1.4-1.5-1.51.41.41.7-1.5-1.3-1.5-1.3-1.2-1.5-1.81.31.2
Lifetime Intake3.03.76.02.31.51.8-2.22.4-1.5-1.8-2.0-2.01.91.91.3-1.7-2.1-1.9-2.2-2.0-1.8-1.22.12.1
Liver weight, left4.06.67.6-2.7-2.4-2.52.8-2.52.52.62.62.6-2.6-2.6-2.52.52.52.62.72.62.52.4-2.7-2.5
Liver weight, right9.516.619.2-3.8-4.3-4.23.7-3.94.24.24.34.3-4.1-4.1-4.44.24.14.43.64.14.14.2-3.5-3.9
Locomotor activity0.30.51.3-1.2-0.4-0.80.9-0.90.70.70.60.6-0.8-0.7-0.00.60.70.60.81.00.70.1-0.8-0.6
Locomotor testing distance0.10.20.6-0.10.40.2-0.20.1-0.4-0.3-0.4-0.50.30.40.8-0.5-0.4-0.5-0.2-0.2-0.3-0.80.30.6
Locomotor testing rearing0.71.42.31.00.70.8-1.31.3-0.8-1.0-1.3-1.41.11.21.0-1.0-1.4-1.5-1.3-1.3-1.1-0.91.31.5
Locomotion in novel chamber0.20.21.4-0.1-1.0-0.50.30.10.60.40.20.2-0.2-0.2-1.20.50.10.20.2-0.30.40.90.00.1
Locomotion in novel chamber post-restriction2.64.35.7-1.9-2.2-2.31.7-2.02.42.22.22.1-2.1-2.1-2.32.22.02.01.72.12.32.0-1.6-1.8
Fecal boli incidents, locomotor time 10.20.30.70.90.40.6-0.70.7-0.6-0.6-0.4-0.30.60.60.4-0.5-0.5-0.3-0.8-0.7-0.4-0.50.80.6
Change in fecal boli incidents, locomotor task4.54.56.7-2.2-2.0-2.22.6-2.12.12.12.01.9-2.1-2.1-1.92.12.01.92.42.22.12.0-2.3-2.1
Time >=10cm from walls, locomotor time 10.10.10.2-0.1-0.2-0.20.1-0.00.30.30.30.1-0.3-0.3-0.00.40.30.10.20.30.4-0.3-0.2-0.4
Bouts of movement, locomotor time 11.51.73.01.31.11.3-1.50.9-1.5-1.4-1.6-1.41.31.31.3-1.4-1.2-1.2-1.0-1.3-1.7-1.51.01.2
Total resting periods, locomotor time 11.82.03.31.31.31.5-1.31.0-1.6-1.5-1.7-1.51.41.41.4-1.6-1.4-1.3-1.0-1.4-1.8-1.51.01.3
Rest time, locomotor task time 10.10.10.5-0.1-0.2-0.20.5-0.10.20.20.20.2-0.2-0.2-0.60.20.10.20.70.20.20.3-0.7-0.1
Distance moved, locomotor task time 10.81.21.8-1.3-1.2-1.10.9-1.01.11.11.21.3-1.1-1.1-0.91.11.21.20.71.21.20.7-0.7-1.0
Vertical activity count, locomotor time 10.20.61.2-1.1-0.9-0.70.8-0.70.70.70.70.8-0.7-0.8-0.30.80.80.80.60.90.90.2-0.7-0.8
Time >=10cm from walls, locomotor time 20.30.40.80.50.60.7-0.70.9-0.4-0.6-0.7-0.90.60.5-0.0-0.4-0.6-0.7-0.7-0.7-0.7-0.20.80.4
Bouts of movement, locomotor time 20.10.10.40.1-0.4-0.2-0.2-0.70.20.30.20.0-0.4-0.4-0.20.30.40.20.40.30.10.1-0.4-0.6
Total resting periods, locomotor time 20.00.00.30.4-0.10.1-0.5-0.4-0.2-0.1-0.2-0.3-0.0-0.00.1-0.10.1-0.20.1-0.0-0.3-0.1-0.1-0.3
Rest time, locomotor task time 21.01.32.21.01.51.2-0.80.8-1.3-1.2-1.2-1.21.11.21.4-1.3-1.2-1.2-0.7-1.0-1.2-1.30.71.1
Distance moved, locomotor task time 20.91.11.8-1.3-1.2-1.00.9-0.71.21.11.01.1-1.0-1.0-1.31.11.01.10.50.91.01.1-0.5-0.9
Vertical activity count, locomotor time 20.40.51.1-0.7-0.9-0.70.7-0.30.80.70.60.6-0.7-0.7-1.10.80.70.60.60.50.61.0-0.6-0.7
Light reinforcement 12.35.78.51.92.82.5-2.01.6-2.9-2.5-2.5-2.52.42.42.9-2.7-2.3-2.4-1.8-2.2-2.6-2.61.82.2
Light reinforcement 22.53.86.21.72.42.2-1.61.4-2.4-2.1-1.9-2.01.91.92.5-2.2-1.8-2.0-1.5-1.7-2.2-2.11.41.7
Bone: marrow area0.51.22.20.11.21.1-0.10.8-1.3-1.1-1.4-1.41.01.11.2-1.3-1.1-1.4-0.1-1.0-1.5-1.10.11.0
Bone: maximum diameter0.81.62.70.11.51.3-0.20.6-1.6-1.3-1.6-1.61.21.21.7-1.5-1.2-1.6-0.1-1.1-1.7-1.50.11.0
Bone: maximum force0.10.20.4-0.00.30.50.00.3-0.6-0.5-0.6-0.60.40.40.4-0.5-0.4-0.60.0-0.4-0.6-0.4-0.00.3
Bone: maximum moment0.20.30.50.00.50.60.00.4-0.7-0.6-0.7-0.70.50.50.6-0.6-0.5-0.7-0.0-0.5-0.7-0.6-0.00.4
Mean time between licks in bursts1.63.84.5-1.9-1.9-2.02.0-1.91.92.02.12.1-2.0-2.0-1.82.02.02.01.92.02.11.7-1.9-1.9
Mean num. licks in bursts0.20.41.41.20.30.6-0.90.8-0.4-0.5-0.5-0.50.60.60.2-0.4-0.6-0.4-0.8-0.7-0.4-0.40.70.5
Cd content in liver0.00.00.1-0.3-0.00.0-0.0-0.2-0.1-0.0-0.1-0.1-0.00.0-0.0-0.1-0.0-0.10.0-0.0-0.0-0.10.0-0.0
Co content in liver5.56.48.02.22.82.7-2.12.4-2.7-2.6-2.7-2.72.52.52.8-2.6-2.4-2.7-2.1-2.5-2.7-2.72.12.2
Cu content in liver0.10.10.30.30.40.4-0.40.6-0.3-0.3-0.2-0.30.40.40.3-0.3-0.3-0.3-0.4-0.4-0.3-0.30.40.4
Fe content in liver1.01.32.71.00.81.1-1.01.6-0.9-1.1-1.0-1.11.31.30.7-1.1-1.4-1.2-1.0-1.3-0.9-0.71.01.6
K content in liver0.30.30.7-0.70.60.50.8-0.1-0.8-0.5-0.6-0.60.40.40.5-0.7-0.3-0.50.8-0.2-0.7-0.6-0.80.2
Mg content in liver0.30.40.7-0.70.70.50.7-0.2-0.8-0.5-0.6-0.60.40.40.6-0.7-0.3-0.60.7-0.2-0.7-0.8-0.70.2
Mn content in liver0.10.10.4-0.6-0.00.10.6-0.2-0.3-0.2-0.4-0.40.10.2-0.0-0.4-0.3-0.50.6-0.1-0.4-0.1-0.60.3
Na content in liver0.50.51.10.70.70.9-0.61.0-0.8-0.8-0.7-0.60.80.80.6-0.7-0.7-0.6-0.6-0.9-0.7-0.60.50.7
Rb content in liver0.10.10.3-0.50.1-0.10.6-0.2-0.10.0-0.0-0.0-0.00.00.0-0.1-0.0-0.10.60.1-0.0-0.2-0.60.1
Se content in liver0.10.10.5-0.1-0.6-0.4-0.0-0.10.40.30.20.1-0.2-0.2-0.70.20.10.10.00.10.20.70.0-0.0
Sr content in liver0.20.10.3-0.3-0.3-0.20.2-0.20.40.30.40.5-0.3-0.4-0.30.50.50.50.30.30.40.2-0.3-0.5
Zn content in liver1.11.32.6-1.6-0.9-1.01.5-1.10.91.01.00.9-1.0-1.1-1.00.91.10.91.51.00.91.0-1.5-1.1
Bone: minimum diameter0.20.41.6-1.2-0.1-0.31.2-0.70.10.30.10.1-0.4-0.4-0.20.10.40.11.10.50.10.4-1.2-0.5
Time in familiar zone, hab. session 10.90.91.8-1.3-0.9-0.91.3-1.00.70.80.70.8-0.9-0.8-1.00.70.80.71.30.80.71.0-1.2-0.8
Time in novel zone, hab. session 10.30.30.90.1-0.9-0.8-0.2-0.20.90.70.70.6-0.5-0.5-0.90.70.40.5-0.00.40.70.80.0-0.3
Total zone transitions, hab. session 10.10.10.20.40.40.4-0.30.2-0.4-0.4-0.3-0.30.30.30.3-0.3-0.3-0.5-0.4-0.3-0.4-0.50.40.1
Total locomotion distance, hab. session 10.10.20.30.20.50.5-0.10.3-0.5-0.5-0.4-0.50.40.40.4-0.5-0.4-0.5-0.2-0.3-0.6-0.40.20.2
Locomotion velocity, hab. session 10.81.11.80.81.41.3-0.70.9-1.3-1.2-1.0-1.11.11.01.3-1.2-1.0-1.2-0.8-0.9-1.1-1.20.70.8
Time in familiar zone, hab. session 20.00.00.00.1-0.20.0-0.1-0.2-0.1-0.0-0.2-0.20.00.0-0.0-0.1-0.0-0.2-0.1-0.1-0.20.00.10.0
Time in novel zone, hab. session 20.50.50.7-0.8-0.6-0.70.8-0.40.80.70.80.8-0.7-0.7-0.60.80.60.80.80.70.80.6-0.8-0.6
Total zone transitions, hab. session 20.10.10.3-0.30.40.20.3-0.2-0.4-0.2-0.2-0.30.10.10.4-0.3-0.1-0.30.4-0.0-0.3-0.6-0.4-0.0
Total locomotion distance, hab. session 20.10.10.40.00.60.40.0-0.1-0.6-0.4-0.3-0.30.30.30.6-0.5-0.2-0.30.1-0.1-0.4-0.6-0.10.1
Locomotion velocity, hab. session 20.20.30.70.20.80.6-0.20.1-0.8-0.6-0.5-0.50.50.50.8-0.7-0.4-0.5-0.2-0.3-0.6-0.90.10.3
Novel to familiar place preference ratio1.01.11.4-1.0-0.9-1.11.0-1.21.11.11.01.0-1.1-1.1-0.71.11.11.11.11.21.10.8-1.1-1.2
Novelty place preference1.61.72.0-1.2-1.2-1.41.2-1.41.41.41.31.3-1.4-1.4-1.01.41.41.31.31.41.41.1-1.3-1.4
Time in novel zone, NPP test1.81.92.2-1.3-1.4-1.51.2-1.41.51.41.41.4-1.4-1.4-1.11.41.41.41.31.41.51.2-1.3-1.4
Total zone transitions, NPP test1.31.82.51.21.51.5-1.21.2-1.5-1.4-1.2-1.31.41.41.5-1.4-1.3-1.3-1.3-1.3-1.2-1.61.21.2
Total locomotion distance, NPP test1.82.53.01.71.71.7-1.51.4-1.7-1.6-1.4-1.51.61.61.6-1.6-1.5-1.5-1.6-1.5-1.5-1.71.51.4
Locomotion velocity, NPP test2.94.05.21.92.32.1-1.81.7-2.2-2.1-2.0-2.02.02.02.2-2.1-1.9-2.0-1.9-1.9-2.0-2.31.81.8
Intraocular pressure5.98.59.8-2.9-2.9-3.12.8-3.13.03.02.92.9-3.0-3.0-2.52.93.02.83.03.13.02.3-3.0-2.8
Delta distance traveled before/after self-admin1.92.02.6-1.6-1.6-1.41.6-1.61.21.41.51.4-1.4-1.4-1.61.21.41.31.41.21.41.6-1.3-1.3
Delta ambulatory time before/after self-admin0.30.41.0-1.0-0.7-0.51.0-0.80.30.50.60.6-0.5-0.5-0.60.40.60.40.70.40.50.6-0.6-0.5
Parametrial fat weight12.830.038.7-5.8-5.1-5.45.3-6.24.95.45.45.5-5.6-5.6-5.25.25.75.65.65.55.25.1-5.6-5.9
Pavlov. Cond. lever latency1.41.73.1-0.8-1.8-1.50.9-1.01.61.41.51.4-1.3-1.3-1.61.51.31.40.81.11.41.6-0.8-1.2
Pavlov. Cond. magazine entry latency0.00.10.20.00.40.3-0.10.0-0.4-0.3-0.2-0.20.20.20.2-0.3-0.2-0.20.1-0.1-0.2-0.3-0.10.2
Pavlov. Cond. change in total contacts0.00.00.1-0.10.30.20.10.1-0.2-0.2-0.1-0.10.10.10.2-0.2-0.1-0.10.2-0.0-0.1-0.3-0.20.1
Pavlov. Cond. index score0.50.61.40.21.20.9-0.40.4-1.1-0.9-0.9-0.80.80.81.0-1.0-0.7-0.8-0.2-0.5-0.8-1.10.10.7
Pavlov. Cond. latency score0.50.61.40.21.20.9-0.40.4-1.1-0.9-0.9-0.80.70.81.0-1.0-0.7-0.8-0.1-0.5-0.8-1.10.10.6
Pavlov. Cond. lever contacts0.91.02.10.51.41.2-0.60.8-1.3-1.1-1.2-1.11.01.01.3-1.2-0.9-1.1-0.4-0.8-1.1-1.30.40.9
Pavlov. Cond. magazine entry number0.30.40.8-0.3-0.9-0.70.4-0.40.90.70.60.6-0.6-0.6-0.60.80.60.60.20.50.60.7-0.2-0.6
Pavlov. Cond. intertrial magazine entries1.41.62.61.11.31.3-1.21.4-1.2-1.2-1.1-1.11.31.31.4-1.2-1.2-1.0-1.6-1.2-1.2-1.41.61.3
Pavlov. Cond. lever-magazine prob. diff.1.01.32.40.61.61.3-0.80.8-1.4-1.2-1.2-1.21.11.21.3-1.3-1.1-1.2-0.6-0.9-1.2-1.50.51.1
Pavlov. Cond. response bias1.11.32.20.81.51.3-0.91.0-1.4-1.3-1.2-1.11.21.21.2-1.3-1.1-1.1-0.7-1.0-1.1-1.40.61.1
Pavlov. Cond. lever latency1.62.12.6-1.5-1.4-1.41.5-1.41.41.41.61.6-1.4-1.4-1.51.41.41.61.51.41.51.5-1.5-1.3
Pavlov. Cond. magazine entry latency0.30.30.60.50.50.6-0.50.5-0.6-0.6-0.8-0.80.60.60.5-0.6-0.6-0.8-0.6-0.6-0.6-0.20.60.4
Pavlov. Cond. change in total contacts0.71.21.81.11.01.0-1.11.0-0.9-1.0-1.3-1.31.01.01.2-1.0-1.0-1.3-1.2-1.0-1.0-1.21.20.9
Pavlov. Cond. index score1.31.72.31.31.21.3-1.31.2-1.2-1.3-1.5-1.51.21.21.3-1.2-1.3-1.5-1.3-1.3-1.3-1.11.31.1
Pavlov. Cond. latency score1.31.72.41.31.21.3-1.31.2-1.3-1.3-1.6-1.61.31.21.2-1.2-1.2-1.5-1.4-1.3-1.3-1.11.41.1
Pavlov. Cond. lever contacts1.11.51.81.31.21.2-1.31.1-1.1-1.2-1.3-1.41.21.21.3-1.1-1.2-1.3-1.3-1.2-1.3-1.31.21.0
Pavlov. Cond. magazine entry number0.20.20.5-0.3-0.3-0.50.3-0.30.50.50.70.7-0.4-0.4-0.40.50.40.70.40.40.50.3-0.4-0.3
Pavlov. Cond. intertrial magazine entries3.55.26.1-2.2-2.3-2.42.2-2.32.42.42.42.4-2.3-2.3-2.12.32.32.52.22.32.32.0-2.2-2.1
Pavlov. Cond. lever-magazine prob. diff.0.81.11.61.01.01.1-1.00.9-1.0-1.0-1.3-1.31.01.01.1-1.0-1.0-1.3-1.0-1.0-1.1-0.91.00.9
Pavlov. Cond. response bias1.72.42.71.51.51.5-1.51.4-1.5-1.5-1.6-1.61.51.51.6-1.5-1.5-1.6-1.6-1.5-1.6-1.61.51.4
Time in closed arm before self-admin0.60.81.5-0.7-1.1-1.00.8-0.81.11.00.80.8-0.9-0.9-1.21.00.80.70.30.90.81.2-0.2-0.8
Time in closed arm after self-admin1.01.02.2-0.8-1.5-1.30.7-0.81.41.11.00.9-1.1-1.0-1.31.20.90.80.41.00.91.4-0.5-0.8
Time in open arm before self-admin0.10.10.40.10.60.3-0.1-0.0-0.3-0.2-0.1-0.10.10.10.6-0.2-0.00.0-0.1-0.0-0.2-0.70.00.1
Time in open arm after self-admin1.21.32.40.81.51.2-0.90.9-1.4-1.2-1.1-1.01.21.21.4-1.3-1.1-1.0-0.9-1.0-1.1-1.41.01.2
Bone: periosteal estimation0.71.62.80.11.61.4-0.10.8-1.7-1.4-1.6-1.61.21.21.5-1.5-1.2-1.5-0.2-1.1-1.7-1.40.11.0
Bone: periosteal perimeter0.30.61.1-0.01.00.8-0.00.3-1.0-0.8-0.9-0.90.70.70.9-0.9-0.6-0.9-0.0-0.6-1.0-1.0-0.00.5
Bone: post-yield work1.11.72.71.60.91.2-1.61.4-1.1-1.2-1.3-1.31.31.20.9-1.1-1.3-1.3-1.6-1.4-1.1-1.11.61.2
Progressive ratio test 1 active lever presses1.72.13.61.71.51.4-1.61.9-1.1-1.4-1.5-1.41.41.51.3-1.3-1.6-1.4-1.4-1.2-1.5-0.91.41.5
Progressive ratio test 1 breakpoint1.72.13.61.71.51.4-1.61.9-1.1-1.4-1.5-1.41.41.51.3-1.3-1.6-1.4-1.4-1.2-1.5-1.01.41.5
Progressive ratio test 1 inactive lever presses3.34.87.02.42.12.2-2.52.7-2.0-2.2-2.1-2.12.32.31.5-2.1-2.4-2.1-2.3-2.3-2.1-1.32.42.3
Progressive ratio test 2 active lever presses0.50.61.71.20.40.6-1.11.3-0.3-0.6-0.8-0.70.70.70.1-0.4-0.8-0.6-0.9-0.9-0.60.00.70.7
Progressive ratio test 2 breakpoint0.40.41.41.10.30.5-1.01.2-0.2-0.5-0.7-0.60.60.6-0.0-0.3-0.7-0.5-0.8-0.8-0.50.10.60.6
Progressive ratio test 2 inactive lever presses1.52.53.81.81.31.6-2.02.0-1.4-1.6-1.6-1.61.61.60.8-1.5-1.7-1.6-1.8-1.7-1.6-0.51.71.6
Incentive Sensitization - Responses0.10.20.70.60.10.5-0.50.7-0.3-0.4-0.4-0.40.50.4-0.1-0.3-0.4-0.3-0.5-0.8-0.20.00.30.3
Incentive Sensitization - Breakpoint0.10.10.40.4-0.00.3-0.30.5-0.2-0.3-0.3-0.20.30.2-0.3-0.1-0.2-0.2-0.4-0.7-0.00.20.20.2
Sum of active levers in priming session hrs 5-60.40.31.2-0.41.10.50.4-0.1-0.8-0.6-0.4-0.40.40.51.0-0.7-0.4-0.4-0.1-0.1-0.5-1.10.10.4
Progressive ratio0.00.00.3-0.3-0.2-0.20.50.00.10.1-0.00.0-0.1-0.0-0.20.0-0.0-0.0-0.00.00.00.5-0.00.1
Food seeking constrained by brief footshock4.45.38.62.72.12.3-2.52.9-1.9-2.3-2.1-2.12.42.41.8-2.1-2.4-2.3-2.7-2.6-2.0-1.52.52.4
Seeking ratio, punishment vs. effort0.40.61.31.10.90.8-1.10.9-0.7-0.8-0.5-0.60.80.70.9-0.6-0.7-0.6-0.7-0.7-0.5-1.00.70.6
Retroperitoneal fat weight22.997.7115.2-10.7-9.8-10.310.3-10.59.710.09.69.6-10.0-9.9-9.99.69.79.69.910.09.59.7-9.7-9.4
Reaction time number correct0.40.71.10.91.00.9-0.80.7-1.0-0.9-0.9-0.90.80.81.0-0.9-0.8-0.9-0.7-0.8-0.7-0.90.70.7
Reaction time mean minus median0.00.10.50.40.00.0-0.50.30.1-0.0-0.00.00.10.1-0.30.0-0.10.1-0.7-0.2-0.10.30.60.1
Reaction time mean minus median AUC0.00.10.1-0.0-0.2-0.3-0.1-0.10.30.30.30.3-0.2-0.2-0.30.30.20.3-0.20.10.20.40.2-0.2
Reaction time num false alarms0.20.30.8-0.80.5-0.30.7-0.9-0.10.20.20.1-0.3-0.20.6-0.10.30.10.90.70.3-0.5-0.8-0.3
Reaction time num false alarms AUC0.20.31.0-0.90.6-0.20.8-1.0-0.10.20.10.1-0.3-0.20.8-0.10.30.10.90.80.3-0.6-0.7-0.3
Reaction time trials correct on left0.40.71.10.91.00.9-0.80.7-1.0-0.9-0.9-0.90.80.81.0-0.9-0.8-0.9-0.7-0.8-0.7-0.90.70.7
Reaction time trials on left0.40.81.20.91.11.0-0.90.7-1.0-0.9-0.9-0.90.90.91.1-0.9-0.8-0.9-0.7-0.9-0.7-1.00.70.8
Reaction time mean1.01.62.2-1.1-1.0-1.21.2-1.11.31.31.31.4-1.3-1.4-1.11.41.41.51.11.41.21.3-1.1-1.4
Reaction time mean AUC0.91.42.0-1.0-0.9-1.11.0-1.01.21.21.21.4-1.2-1.2-1.01.31.31.41.01.31.11.2-1.0-1.3
Median of all reaction times1.42.02.6-1.4-1.0-1.31.4-1.31.41.41.41.5-1.4-1.5-1.11.51.61.61.31.51.31.3-1.4-1.6
Reaction time omissions0.00.10.4-0.20.60.10.00.0-0.3-0.2-0.2-0.20.20.20.3-0.3-0.3-0.2-0.1-0.1-0.2-0.10.10.3
Reaction time false alarm rate0.40.61.6-1.20.1-0.71.1-1.30.30.60.60.5-0.7-0.60.20.40.70.51.21.20.7-0.1-1.1-0.7
Reaction time premature initiation rate0.10.20.3-0.1-0.4-0.50.1-0.30.50.40.40.4-0.4-0.4-0.50.50.30.5-0.10.40.40.4-0.0-0.4
Reaction time premature initiations0.00.00.10.40.10.1-0.40.1-0.0-0.1-0.1-0.10.10.10.1-0.0-0.1-0.0-0.4-0.10.0-0.10.30.1
Std. dev. reaction times0.20.40.7-0.4-0.5-0.60.5-0.40.70.60.60.7-0.6-0.6-0.70.70.60.80.40.60.60.8-0.5-0.7
Reaction time trials completed0.40.81.20.91.11.0-0.90.7-1.0-0.9-0.9-0.90.90.91.1-0.9-0.8-0.9-0.7-0.9-0.7-1.00.70.8
Reaction time trials AUC0.51.01.41.11.11.1-1.00.9-1.1-1.0-1.0-1.01.01.01.2-1.0-0.9-1.0-0.9-1.0-0.8-1.10.90.9
Run reversals in cocaine runway, females0.10.10.30.2-0.2-0.10.00.10.30.20.40.4-0.1-0.2-0.20.30.20.30.10.20.5-0.0-0.2-0.2
Run reversals in cocaine runway, males0.10.10.50.70.00.3-0.50.5-0.1-0.2-0.1-0.20.30.30.3-0.1-0.3-0.3-0.4-0.3-0.1-0.60.30.2
Latency to leave start box in cocaine runway0.60.61.10.60.70.9-0.31.0-0.7-0.8-0.9-0.90.90.80.7-0.7-0.8-0.8-0.8-1.1-0.8-0.40.70.8
Latency to leave start box in cocaine runway, F0.20.30.80.20.90.5-0.00.4-0.5-0.5-0.5-0.50.50.50.9-0.5-0.4-0.4-0.6-0.5-0.5-0.60.60.5
Latency to leave start box in cocaine runway, M0.20.20.70.6-0.40.4-0.40.8-0.1-0.4-0.4-0.40.40.4-0.5-0.2-0.4-0.4-0.3-0.8-0.40.50.10.4
Std. dev. time between licks in bursts0.20.31.2-1.1-0.1-0.40.9-1.00.10.40.40.4-0.5-0.5-0.30.20.60.50.80.60.20.1-0.7-0.6
Total sessions with >9 infusions1.11.42.91.50.51.0-1.51.7-0.7-1.0-1.2-1.31.21.20.3-0.9-1.3-1.3-1.3-1.4-1.1-0.21.31.4
Short access day 1 total inactive lever presses6.78.812.02.73.53.1-3.02.8-3.3-3.1-3.0-3.03.03.12.7-3.2-3.0-2.9-2.8-2.6-2.8-2.52.93.0
Short access day 10 total inactive lever presses1.74.14.92.02.22.0-2.21.8-2.1-2.0-1.9-1.92.02.02.1-2.1-2.0-1.9-2.2-1.7-1.8-2.02.12.0
Short access day 1 total infusions4.25.58.22.41.82.2-2.52.9-2.0-2.3-2.5-2.62.42.41.5-2.3-2.6-2.6-2.5-2.6-2.2-1.22.42.7
Short access day 10 total infusions2.22.94.61.91.61.7-1.82.1-1.5-1.7-1.8-1.71.71.71.3-1.6-1.8-1.7-1.7-1.6-1.5-1.31.71.8
Short access total infusions1.51.93.51.50.81.2-1.61.9-1.0-1.3-1.5-1.51.41.40.5-1.2-1.6-1.4-1.5-1.5-1.2-0.51.61.6
Short access day 1 locomotion3.54.37.82.51.41.9-2.82.5-1.6-1.9-2.1-2.22.12.11.3-1.8-2.2-2.1-2.3-2.3-1.9-1.12.32.3
Short access day 10 total locomotion1.42.55.52.01.61.5-2.31.6-1.4-1.5-1.5-1.41.51.51.5-1.5-1.6-1.3-1.9-1.3-1.5-1.22.01.5
Short access total locomotion0.40.51.61.10.10.5-1.31.0-0.2-0.5-0.7-0.60.60.60.2-0.4-0.8-0.6-0.9-0.6-0.50.11.00.7
One hour access (0.3 mA shock)1.41.62.81.71.01.3-1.51.6-1.1-1.2-1.2-1.21.31.20.7-1.1-1.2-1.2-1.5-1.4-1.4-0.71.31.2
Compulsive drug intake1.41.63.2-1.7-0.8-1.11.7-1.80.81.11.51.3-1.2-1.2-0.61.01.41.21.51.41.40.2-1.4-1.3
One hour access (shock baseline)2.03.15.32.31.41.8-2.32.3-1.4-1.7-1.9-1.71.81.71.3-1.5-1.8-1.6-2.0-2.0-1.9-0.91.71.7
Social response proportion0.30.41.2-0.5-0.6-0.50.8-0.30.60.50.40.4-0.5-0.5-0.70.60.50.51.10.50.20.9-1.1-0.5
Social responses0.20.20.7-0.5-0.1-0.30.6-0.50.30.30.20.3-0.4-0.4-0.40.30.30.40.80.4-0.10.7-0.8-0.4
Social time0.30.42.0-0.4-0.7-0.60.4-0.40.70.60.40.5-0.5-0.6-1.10.60.50.40.40.30.51.4-0.5-0.5
Soleus weight4.413.016.53.34.03.8-3.33.4-3.8-3.7-3.6-3.73.63.63.9-3.6-3.4-3.6-3.5-3.4-3.7-4.13.53.2
Bone: stiffness0.00.00.00.20.10.1-0.2-0.1-0.2-0.1-0.1-0.10.10.10.2-0.10.0-0.1-0.1-0.2-0.2-0.10.1-0.0
Tibialis anterior weight3.612.014.23.13.73.5-3.33.1-3.6-3.5-3.6-3.63.43.53.7-3.6-3.4-3.5-3.3-3.3-3.7-3.83.33.2
Time to tail flick, vehicle, before self-admin0.80.81.8-0.3-1.2-1.00.2-0.41.31.00.90.9-0.9-0.9-1.21.10.70.80.40.71.21.3-0.5-0.6
Time to tail flick, vehicle, after self-admin3.14.15.7-1.8-2.4-2.21.9-1.82.42.21.81.8-2.1-2.1-2.12.21.91.81.82.02.22.2-1.8-2.0
Time to tail flick, test, before self-admin0.10.10.20.40.10.2-0.50.4-0.1-0.3-0.3-0.30.30.30.4-0.2-0.4-0.2-0.4-0.2-0.2-0.30.50.4
Time to tail flick, test, after self-admin0.20.20.60.80.50.4-0.30.6-0.2-0.4-0.3-0.30.40.30.4-0.2-0.4-0.4-0.6-0.3-0.3-0.20.50.3
Delta time to tail flick, vehicle, before/after SA0.10.10.7-0.7-0.4-0.30.8-0.40.20.30.10.1-0.3-0.3-0.20.20.20.10.40.40.20.2-0.4-0.3
Delta time to tail flick, test, before/after SA1.41.52.41.31.61.4-0.91.1-1.3-1.3-1.1-1.21.21.21.3-1.2-1.1-1.2-1.2-1.2-1.3-1.21.11.0
Tibia length2.97.910.2-2.9-2.8-2.72.9-2.72.72.72.72.7-2.8-2.8-2.82.72.82.83.22.72.72.9-3.2-2.7
Ambulatory time before self-admin0.00.00.10.20.10.2-0.30.0-0.1-0.1-0.10.00.0-0.00.10.00.10.1-0.1-0.0-0.0-0.20.0-0.2
Ambulatory time after self-admin1.51.82.2-1.4-1.5-1.21.4-1.51.01.31.41.4-1.3-1.4-1.41.21.51.41.31.21.41.2-1.3-1.4
Bone: tissue strength0.90.91.2-0.7-1.0-0.90.7-0.81.01.01.11.1-0.9-1.0-0.81.01.01.10.90.91.10.6-0.9-0.9
Total heroin consumption2.83.35.51.72.01.8-1.71.5-1.9-1.8-1.9-1.81.81.82.3-1.8-1.7-1.8-1.7-1.6-1.8-2.21.71.7
Bone: trabecular number2.94.77.31.42.72.5-1.31.9-2.6-2.4-2.3-2.32.22.22.7-2.4-2.2-2.3-1.3-2.0-2.3-2.51.22.0
Bone: trabecular spacing2.73.54.8-1.2-2.2-2.01.2-1.72.22.02.12.2-1.9-1.9-2.22.12.02.21.11.82.21.8-1.0-1.7
Bone: trabecular thickness0.60.71.2-0.01.11.00.00.6-1.1-0.9-1.0-1.10.90.91.1-1.0-0.9-1.10.0-0.7-1.0-0.8-0.00.7
Bone: trabecular tissue density0.30.50.80.90.50.7-0.90.6-0.8-0.7-0.5-0.50.70.70.6-0.7-0.6-0.5-0.8-0.8-0.7-0.50.80.6
Water consumed over 24 hours0.30.41.30.11.10.7-0.20.1-1.0-0.7-0.7-0.70.50.61.1-0.8-0.5-0.6-0.3-0.4-0.9-0.80.30.4
Number of responses in last shaping day0.30.40.80.5-0.40.5-0.50.9-0.3-0.5-0.8-0.80.60.5-0.4-0.4-0.7-0.7-0.3-0.9-0.90.30.30.7