Hub : Genes

Dennd10

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	mRNA stability	Dennd10	0.02	0.02	4.2e-03	0.02	0.02	0.01	0.02	1.2e-03	8.7e-04	2.1e-02	1.4e-03
2	Adipose	gene expression	Dennd10	0.03	0.02	1.9e-04	0.04	0.03	0.03	0.04	8.9e-05	2.0e-04	1.0e-04	8.4e-05
3	Brain	mRNA stability	Dennd10	0.04	0.02	3.3e-03	0.02	0.02	0.01	0.01	2.5e-03	6.3e-03	2.3e-02	2.5e-02
4	IL	gene expression	Dennd10	0.16	0.11	9.0e-03	0.11	0.1	0.08	0.08	1.4e-03	2.9e-03	6.6e-03	6.7e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	2.5	4.2	9.6	-3.1	-1.7	1.4	1.4
Area under the delay curve	0.3	0.4	1.0	-0.0	-1.0	0.4	0.5
BMI with tail	18.9	61.2	117.3	-10.8	-9.6	4.2	4.1
BMI without tail	15.8	32.7	56.1	-7.5	-6.7	3.9	3.9
Body weight	18.3	76.9	145.9	-12.1	-10.6	5.0	4.9
Weight adjusted by age	3.3	3.7	6.8	-2.6	-2.6	0.8	0.8
Bone surface	2.1	3.7	8.0	-2.8	-1.9	1.3	1.3
Bone volume	3.5	6.0	12.8	-3.6	-2.8	1.3	1.3
Breakpoint value in progressive ratio session	2.6	2.9	4.8	-1.8	-2.2	1.3	1.3
Number of licking bursts	0.9	1.1	1.9	-0.7	-0.4	1.4	1.3
Context. condit. distance diff. score	0.1	0.1	0.1	-0.2	0.3	0.3	0.3
Locomotion velocity, session 1	0.6	0.7	1.3	1.1	1.2	0.0	0.0
Locomotion distance, session 1	2.3	2.9	4.7	2.2	1.9	-1.3	-1.3
Locomotion velocity, session 2	1.7	1.9	2.6	1.6	1.3	-1.3	-1.4
Locomotion distance, session 2	0.4	0.5	1.1	-0.1	-0.2	-1.0	-1.0
Locomotion velocity, session 3	1.7	2.0	3.4	1.8	1.7	-0.9	-0.9
Locomotion distance, session 3	0.9	1.0	1.5	1.2	1.2	-0.7	-0.8
Stereotopy head waving bouts, day 3	0.6	0.7	1.3	1.1	0.5	-0.9	-0.8
Stereotopy head waving duration, day 3	0.5	0.6	1.5	1.2	0.3	-0.7	-0.7
Locomotion velocity, session 7	0.0	0.0	0.1	0.1	0.3	0.2	0.2
Locomotion distance, session 7	0.1	0.2	0.6	-0.7	-0.2	-0.3	-0.3
Stereotopy head waving bouts, day 7	0.8	0.8	1.6	0.4	-0.3	1.3	1.3
Stereotopy head waving duration, day 7	1.0	1.2	2.2	0.6	-0.1	1.5	1.5
Locomotion velocity, session 8	0.9	1.1	3.5	1.0	1.9	-0.2	-0.2
Locomotion distance, session 8	0.4	0.6	1.6	0.4	1.3	-0.6	-0.6
Degree of sensitization distance	1.3	1.3	3.3	-1.8	-1.2	0.5	0.5
Degree of sensitization stereotypy	1.3	1.5	2.6	-0.2	-0.9	1.6	1.6
Conditioned locomotion	0.0	0.0	0.1	0.3	-0.0	0.0	0.0
Cocaine response after cond. corrected	6.5	7.3	9.6	2.2	2.2	-3.1	-3.1
Cocaine response after cond. not corrected	5.6	6.2	6.6	2.3	2.5	-2.6	-2.6
Cocaine response before conditioning	1.2	1.5	2.9	-0.5	0.1	1.7	1.7
Saline control response	0.4	0.6	1.0	1.0	-0.0	-0.8	-0.8
Bone: connectivity density	0.3	0.5	1.1	-1.1	-0.1	0.6	0.6
Bone: cortical apparent density	7.5	9.9	13.5	3.7	3.4	-2.7	-2.7
Bone: cortical area	8.4	12.7	23.0	-4.8	-4.5	2.0	2.0
Bone: cortical porosity	1.4	1.5	2.6	-1.6	-1.2	1.0	1.0
Bone: cortical porosity	2.6	2.8	4.2	-2.1	-1.8	1.4	1.4
Bone: cortical thickness	4.0	6.6	12.9	-3.6	-3.5	0.7	0.7
Bone: cortical thickness	2.9	3.3	9.2	-2.0	-3.0	-0.2	-0.2
Bone: cortical tissue density	8.1	10.6	14.8	3.8	3.6	-2.7	-2.7
Condit. Reinf. active minus inactive responses	0.7	0.8	2.7	0.5	1.7	-0.2	-0.3
Condit. Reinf. active-inactive response ratio	0.8	0.8	2.5	0.9	1.6	-0.1	-0.1
Condit. Reinf. active responses	0.3	0.3	1.1	-1.1	0.4	0.1	0.1
Condit. Reinf. inactive responses	1.5	1.7	5.2	-2.3	-1.1	0.5	0.5
Incentive salience index mean	0.6	0.7	2.2	0.3	1.5	-0.5	-0.6
Condit. Reinf. lever presses	0.5	0.6	1.3	0.2	1.1	-0.8	-0.8
Condit. Reinf. active minus inactive responses	3.3	4.0	4.7	-2.2	-1.8	2.1	2.0
Condit. Reinf. active-inactive response ratio	3.8	4.0	4.5	-2.0	-2.1	1.9	1.9
Condit. Reinf. active responses	3.8	5.2	6.7	-2.6	-1.9	2.3	2.3
Condit. Reinf. inactive responses	1.4	1.8	2.6	-1.6	-0.9	1.4	1.4
Condit. Reinf. lever presses	1.7	2.2	4.2	-2.1	-1.5	1.1	1.1
Condit. Reinf. lever reinforcers received	2.5	3.5	4.5	-2.1	-1.3	2.0	1.9
Conditioned reinforcement - actives	3.0	3.0	5.3	2.2	2.3	-1.0	-0.9
Conditioned reinforcement - inactives	0.2	0.2	0.6	0.4	0.8	-0.1	-0.2
Conditioned locomotion	2.2	2.6	5.2	1.8	2.3	-1.0	-0.9
Patch foraging indifference point 0 sec	3.2	5.2	9.8	-3.1	-2.9	1.1	1.1
Patch foraging indifference point AUC	0.2	0.3	0.8	-0.3	-0.9	0.3	0.3
Delay disc. indifference point, 0s delay	0.2	0.3	0.8	-0.5	-0.9	-0.2	-0.1
Delay disc. indifference point, 16s delay	0.6	0.6	0.9	0.1	-0.7	1.0	0.9
Delay disc. indifference point, 2s delay	0.4	0.4	0.6	0.8	-0.2	-0.8	-0.7
Delay disc. indifference point, 24s delay	0.2	0.2	0.8	-0.2	-0.9	0.3	0.3
Delay disc. indifference point, 4s delay	0.2	0.2	0.6	0.1	-0.8	0.2	0.3
Delay disc. indifference point, 8s delay	0.1	0.1	0.3	0.5	-0.3	-0.1	-0.1
Indifference point function ln k	0.1	0.2	0.3	-0.4	-0.0	-0.6	-0.5
Indifference point function log k	0.1	0.2	0.3	-0.4	-0.0	-0.6	-0.5
Patch foraging total patch changes 0 sec	4.0	6.4	11.8	-3.4	-3.3	1.2	1.2
Patch foraging total patch changes 12 sec	3.1	4.0	6.6	-2.6	-2.4	1.3	1.3
Patch foraging total patch changes 18 sec	1.7	2.2	4.3	-2.1	-1.8	0.9	0.9
Patch foraging total patch changes 24 sec	0.5	0.6	1.0	-1.0	-0.9	0.7	0.6
Patch foraging total patch changes 6 sec	3.3	4.8	8.0	-2.8	-2.8	1.3	1.3
Patch foraging time to switch 0 sec	0.6	1.0	2.0	1.3	1.4	-0.4	-0.4
Patch foraging water rate 0 sec	1.4	2.3	4.8	-2.0	-2.2	0.3	0.3
Patch foraging water rate 12 sec	2.2	3.4	5.2	-2.3	-2.3	1.3	1.3
Patch foraging water rate 18 sec	0.4	0.6	1.0	-0.7	-1.0	-0.7	-0.7
Patch foraging water rate 24 sec	1.5	2.1	4.5	-1.8	-2.1	-0.6	-0.6
Patch foraging water rate 6 sec	0.8	1.2	2.6	-1.4	-1.6	-0.2	-0.2
Seeking ratio, delayed vs. immediate footshock	5.0	5.8	10.2	2.9	3.2	-1.5	-1.5
Distance traveled before self-admin	2.6	2.8	4.0	1.7	0.3	-2.0	-2.0
Distance traveled after self-admin	2.6	2.8	3.5	1.9	1.4	-1.7	-1.7
Extensor digitorum longus weight	1.5	5.8	10.9	-3.3	-3.0	1.3	1.3
Bone: elastic displacement	0.2	0.2	0.4	0.3	-0.7	-0.3	-0.3
Bone: elastic work	0.9	1.2	3.6	-0.7	-1.9	-0.6	-0.6
Bone: endosteal estimation	1.5	3.3	5.6	-2.4	-2.1	1.3	1.3
Bone: endosteal perimeter	2.7	5.5	9.3	-2.7	-3.0	1.7	1.7
Epididymis fat weight	26.1	60.9	112.8	-10.6	-8.9	5.1	5.1
Delta time in closed arm before/after self-admin	0.7	0.7	1.0	0.3	0.9	-1.0	-1.0
Delta time in open arm before/after self-admin	3.9	3.7	6.1	-1.5	-0.7	2.5	2.5
Diff in mean of infusions in LGA sessions	0.9	0.9	1.3	-0.6	-0.9	1.1	1.1
Delay discount exponential model param	0.3	0.4	1.2	-0.0	1.1	-0.3	-0.4
Extinction: sum of active levers before priming	0.7	0.7	1.3	-0.4	0.0	1.1	1.1
Active lever presses in extinction session 6	0.9	0.8	2.2	-1.0	-1.5	0.3	0.3
Bone: final force	4.6	7.4	14.1	-3.8	-3.7	1.0	1.0
Bone: final moment	5.1	8.2	15.9	-4.0	-3.8	1.2	1.2
Food consumed during 24 hour testing period	0.2	0.3	0.7	-0.8	-0.6	0.2	0.1
Glucose	8.0	12.0	14.8	-3.6	-3.9	3.2	3.2
Heart weight	6.8	9.7	15.8	-3.7	-4.0	2.1	2.1
Delay discount hyperbolic model param	0.2	0.2	0.9	-0.2	1.0	-0.1	-0.2
Intermittent access intake day 1-15 change	0.2	0.2	0.3	-0.3	-0.3	0.5	0.5
Intermittent access intake escalation	0.0	0.0	0.1	0.2	-0.0	-0.2	-0.2
Intermittent access intake escalation 2	0.2	0.2	0.3	-0.5	-0.5	0.5	0.5
Intermitt. access day 1 inactive lever presses	0.7	0.8	1.5	-1.2	-1.0	0.6	0.6
Intermitt. access day 15 inactive lever presses	0.6	0.7	2.2	-0.7	-1.5	0.1	0.0
Intermitt. access escalation Index	0.1	0.1	0.2	-0.1	0.5	0.0	0.0
Intermittent access day 1 total infusions	0.3	0.4	0.7	0.8	0.8	-0.3	-0.3
Intermittent access day 15 total infusions	0.3	0.3	0.6	0.8	0.6	-0.4	-0.4
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.2	0.5	0.2	-0.0	-0.0
Intermittent access total infusions	0.5	0.6	1.1	1.1	0.9	-0.3	-0.4
Intermittent access day 1 locomotion	2.8	3.0	3.9	1.9	2.0	-1.4	-1.5
Intermittent access day 15 total locomotion	0.3	0.3	0.6	-0.3	-0.2	0.8	0.7
Intermittent access total locomotion	1.3	1.5	2.0	1.3	1.4	-1.0	-1.0
Intermittent access standard deviation	0.5	0.5	1.1	0.1	0.0	1.0	1.0
Left kidney weight	5.3	14.9	30.8	-5.5	-5.3	0.3	0.3
Right kidney weight	5.1	14.2	28.9	-5.4	-5.3	-0.1	-0.1
Cocaine induced anxiety	2.6	3.0	4.8	2.2	2.1	-1.2	-1.2
Post-drug Anxiety	0.4	0.4	0.9	0.9	1.0	-0.1	-0.1
Baseline Anxiety	2.3	2.4	3.0	-1.7	-1.2	1.6	1.6
Tail length	1.2	3.7	4.3	-2.1	-2.1	1.7	1.8
Length with tail	2.6	9.5	16.1	-4.0	-3.6	2.1	2.1
Length without tail	2.8	6.0	13.0	-3.6	-2.9	1.1	1.1
Times rat made contact with spout	1.0	1.1	2.4	-1.5	-1.2	0.6	0.6
Lifetime Intake	0.9	1.0	1.9	1.4	1.1	-0.7	-0.7
Liver weight, left	4.9	7.9	14.3	-3.8	-3.1	2.0	2.0
Liver weight, right	8.4	14.0	25.9	-5.1	-4.0	2.7	2.7
Locomotor activity	0.0	0.0	0.2	0.1	0.4	0.0	0.0
Locomotor testing distance	0.5	0.9	0.9	1.0	0.9	-0.9	-1.0
Locomotor testing rearing	0.2	0.3	0.4	0.6	-0.3	-0.6	-0.7
Locomotion in novel chamber	0.8	1.0	1.8	-0.0	-0.6	-1.3	-1.3
Locomotion in novel chamber post-restriction	2.1	2.5	4.2	1.2	0.4	-2.1	-2.1
Fecal boli incidents, locomotor time 1	1.2	1.3	2.2	-0.7	-0.7	1.5	1.4
Change in fecal boli incidents, locomotor task	0.3	0.3	1.0	-1.0	-0.3	0.0	0.0
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.2	0.2	0.5	0.5	0.4
Bouts of movement, locomotor time 1	0.6	0.6	0.8	-0.9	-0.5	0.8	0.9
Total resting periods, locomotor time 1	0.3	0.4	0.6	-0.8	-0.6	0.4	0.5
Rest time, locomotor task time 1	0.9	1.0	1.8	-0.2	-0.5	-1.3	-1.4
Distance moved, locomotor task time 1	0.1	0.1	0.4	0.6	0.4	0.1	0.1
Vertical activity count, locomotor time 1	0.4	0.5	0.9	0.9	0.9	-0.4	-0.3
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.2	-0.5	-0.2	-0.1	-0.1
Bouts of movement, locomotor time 2	0.1	0.1	0.2	0.5	-0.0	-0.3	-0.2
Total resting periods, locomotor time 2	0.1	0.1	0.3	0.6	-0.0	-0.4	-0.3
Rest time, locomotor task time 2	0.1	0.1	0.2	0.5	0.1	-0.4	-0.4
Distance moved, locomotor task time 2	0.1	0.1	0.2	0.1	0.3	-0.4	-0.4
Vertical activity count, locomotor time 2	0.1	0.1	0.4	0.2	0.6	-0.2	-0.3
Light reinforcement 1	0.6	1.2	2.1	0.5	0.5	-1.4	-1.5
Light reinforcement 2	0.1	0.1	0.2	0.4	0.5	-0.0	-0.1
Bone: marrow area	1.7	3.6	6.1	-2.5	-2.2	1.3	1.3
Bone: maximum diameter	5.9	10.8	16.4	-4.1	-3.6	2.6	2.6
Bone: maximum force	3.7	6.4	13.3	-3.6	-3.3	0.8	0.8
Bone: maximum moment	4.0	6.9	14.5	-3.8	-3.3	1.0	1.0
Mean time between licks in bursts	0.6	0.8	1.3	-0.7	0.6	1.1	1.2
Mean num. licks in bursts	0.6	0.8	1.6	-0.1	-0.2	-1.3	-1.2
Cd content in liver	0.8	0.9	2.1	0.7	1.5	-0.7	-0.7
Co content in liver	0.5	0.6	1.2	0.0	0.1	-1.1	-1.1
Cu content in liver	0.2	0.2	0.5	-0.5	-0.7	0.2	0.2
Fe content in liver	0.0	0.0	0.0	-0.1	0.1	0.2	0.2
K content in liver	0.2	0.2	0.9	-0.3	-0.9	0.1	0.1
Mg content in liver	0.4	0.4	1.5	-0.0	-1.2	-0.0	-0.0
Mn content in liver	0.2	0.3	0.4	-0.2	-0.5	-0.6	-0.6
Na content in liver	2.4	2.6	5.7	-1.3	-2.4	1.2	1.2
Rb content in liver	0.3	0.3	1.1	1.1	0.3	-0.3	-0.3
Se content in liver	0.0	0.1	0.2	0.4	0.1	-0.1	-0.1
Sr content in liver	5.9	5.4	7.9	2.8	1.6	-2.4	-2.4
Zn content in liver	1.3	1.4	2.5	0.7	-0.6	-1.6	-1.6
Bone: minimum diameter	5.1	9.5	15.3	-3.9	-3.7	2.1	2.1
Time in familiar zone, hab. session 1	1.5	1.4	3.1	-1.1	-1.8	0.8	0.8
Time in novel zone, hab. session 1	1.8	1.7	5.0	1.4	2.2	0.0	0.0
Total zone transitions, hab. session 1	0.3	0.4	0.7	0.6	0.1	-0.8	-0.8
Total locomotion distance, hab. session 1	0.1	0.1	0.3	0.1	0.5	0.2	0.2
Locomotion velocity, hab. session 1	0.0	0.0	0.2	-0.0	0.4	0.0	0.1
Time in familiar zone, hab. session 2	1.2	1.2	2.2	-0.5	0.5	1.5	1.5
Time in novel zone, hab. session 2	0.3	0.3	0.4	0.2	-0.5	-0.6	-0.6
Total zone transitions, hab. session 2	0.1	0.2	0.3	0.1	-0.3	-0.5	-0.5
Total locomotion distance, hab. session 2	0.3	0.4	0.8	-0.9	-0.7	0.4	0.5
Locomotion velocity, hab. session 2	0.3	0.4	0.8	-0.9	-0.9	0.3	0.3
Novel to familiar place preference ratio	0.5	0.5	0.8	-0.5	0.4	0.9	0.9
Novelty place preference	0.4	0.4	0.7	-0.3	0.4	0.8	0.8
Time in novel zone, NPP test	1.3	1.3	2.4	-0.8	0.3	1.5	1.5
Total zone transitions, NPP test	0.3	0.4	0.6	-0.5	-0.4	-0.8	-0.8
Total locomotion distance, NPP test	0.1	0.2	0.3	-0.4	-0.0	-0.5	-0.5
Locomotion velocity, NPP test	0.9	1.2	2.4	0.1	0.2	-1.5	-1.5
Intraocular pressure	0.7	1.0	1.6	-1.0	0.0	1.3	1.3
Delta distance traveled before/after self-admin	0.6	0.6	2.1	0.6	1.5	-0.1	-0.1
Delta ambulatory time before/after self-admin	0.5	0.6	2.0	0.4	1.4	-0.2	-0.2
Parametrial fat weight	19.5	38.0	68.1	-8.3	-7.1	4.1	4.1
Pavlov. Cond. lever latency	0.2	0.2	0.6	0.7	0.6	0.1	0.2
Pavlov. Cond. magazine entry latency	0.5	0.7	1.6	-1.3	-0.8	0.5	0.5
Pavlov. Cond. change in total contacts	3.0	3.2	5.1	-2.3	-1.6	1.6	1.6
Pavlov. Cond. index score	0.9	1.1	2.4	-1.5	-1.1	0.7	0.6
Pavlov. Cond. latency score	0.7	0.9	1.9	-1.4	-1.0	0.6	0.6
Pavlov. Cond. lever contacts	0.8	1.0	1.7	-1.3	-1.1	0.7	0.7
Pavlov. Cond. magazine entry number	0.8	1.0	2.2	1.5	0.9	-0.8	-0.7
Pavlov. Cond. intertrial magazine entries	0.8	1.0	2.9	-1.7	-1.0	-0.1	-0.0
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.3	2.7	-1.7	-1.1	0.9	0.8
Pavlov. Cond. response bias	0.5	0.6	1.4	-1.2	-0.9	0.4	0.4
Pavlov. Cond. lever latency	1.6	2.1	4.0	2.0	0.9	-1.3	-1.3
Pavlov. Cond. magazine entry latency	0.4	0.5	1.0	-0.2	0.4	0.9	1.0
Pavlov. Cond. change in total contacts	0.7	1.0	1.3	-1.2	-0.5	1.1	1.1
Pavlov. Cond. index score	0.5	0.7	1.1	-1.1	-0.2	0.9	0.9
Pavlov. Cond. latency score	0.5	0.6	1.1	-1.0	-0.3	0.7	0.8
Pavlov. Cond. lever contacts	1.0	1.3	2.4	-1.5	-0.8	1.0	1.1
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	0.2	-0.2	-0.4	-0.5
Pavlov. Cond. intertrial magazine entries	1.6	2.1	4.8	-1.9	-2.2	-0.0	-0.1
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.6	-0.8	-0.1	0.7	0.8
Pavlov. Cond. response bias	1.2	1.7	2.2	-1.5	-0.4	1.5	1.5
Time in closed arm before self-admin	0.1	0.1	0.3	0.5	0.0	0.3	0.3
Time in closed arm after self-admin	0.9	0.9	1.1	1.0	0.7	-1.0	-1.0
Time in open arm before self-admin	0.4	0.4	1.0	1.0	0.7	-0.4	-0.4
Time in open arm after self-admin	2.0	2.3	4.3	-0.6	-0.4	2.1	2.1
Bone: periosteal estimation	5.3	10.9	19.7	-4.4	-4.1	1.8	1.8
Bone: periosteal perimeter	7.5	12.5	21.4	-4.3	-4.6	2.2	2.2
Bone: post-yield work	0.9	1.2	3.1	-1.8	-0.7	0.7	0.7
Progressive ratio test 1 active lever presses	1.2	1.3	2.0	1.4	1.1	-1.0	-1.0
Progressive ratio test 1 breakpoint	1.0	1.1	1.9	1.4	0.9	-0.9	-0.9
Progressive ratio test 1 inactive lever presses	0.4	0.4	0.7	0.6	0.9	-0.5	-0.6
Progressive ratio test 2 active lever presses	0.1	0.1	0.5	-0.1	-0.7	-0.1	-0.0
Progressive ratio test 2 breakpoint	0.1	0.1	0.5	-0.2	-0.7	-0.2	-0.1
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.1	-0.4	0.0	0.1	0.2
Incentive Sensitization - Responses	1.0	1.0	2.1	-1.1	-1.4	0.5	0.6
Incentive Sensitization - Breakpoint	0.9	1.0	1.8	-1.1	-1.3	0.6	0.7
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	-0.2	-0.0	0.4	0.4
Progressive ratio	2.4	2.7	5.0	2.2	1.4	-1.4	-1.4
Food seeking constrained by brief footshock	3.6	4.5	8.6	2.9	2.8	-0.8	-0.8
Seeking ratio, punishment vs. effort	0.1	0.1	0.3	0.0	0.5	0.2	0.2
Retroperitoneal fat weight	29.2	95.8	175.4	-13.2	-11.3	6.3	6.3
Reaction time number correct	0.7	1.0	1.2	-0.9	-1.1	1.1	1.0
Reaction time mean minus median	0.2	0.2	0.4	0.6	-0.2	-0.5	-0.5
Reaction time mean minus median AUC	0.6	0.8	0.9	1.0	-0.7	-0.9	-0.9
Reaction time num false alarms	0.2	0.3	0.9	-0.9	-0.2	-0.2	-0.2
Reaction time num false alarms AUC	0.3	0.4	1.2	-1.1	-0.6	-0.1	-0.1
Reaction time trials correct on left	0.7	1.0	1.2	-0.9	-1.1	1.1	1.0
Reaction time trials on left	0.7	1.0	1.2	-0.9	-1.1	1.1	1.0
Reaction time mean	1.3	1.8	4.7	2.2	1.3	-0.7	-0.7
Reaction time mean AUC	1.8	2.4	5.9	2.4	1.3	-1.0	-1.0
Median of all reaction times	1.7	2.3	5.7	2.4	1.5	-0.8	-0.8
Reaction time omissions	0.1	0.2	0.3	0.3	0.5	0.3	0.3
Reaction time false alarm rate	0.1	0.2	0.5	-0.7	0.1	-0.4	-0.4
Reaction time premature initiation rate	0.3	0.4	0.5	0.6	0.4	-0.7	-0.7
Reaction time premature initiations	0.0	0.0	0.1	-0.0	-0.4	-0.1	-0.2
Std. dev. reaction times	0.1	0.1	0.4	0.6	-0.0	-0.2	-0.2
Reaction time trials completed	0.7	1.0	1.2	-0.9	-1.1	1.1	1.0
Reaction time trials AUC	1.0	1.4	1.7	-1.2	-1.3	1.2	1.1
Run reversals in cocaine runway, females	0.4	0.4	0.5	0.5	0.4	0.7	0.7
Run reversals in cocaine runway, males	2.4	2.3	3.5	1.4	0.6	-1.9	-1.9
Latency to leave start box in cocaine runway	0.8	0.9	1.7	0.2	-0.5	1.3	1.3
Latency to leave start box in cocaine runway, F	0.8	0.9	1.3	-0.4	-0.7	1.2	1.2
Latency to leave start box in cocaine runway, M	0.2	0.2	0.3	0.6	-0.3	0.4	0.4
Std. dev. time between licks in bursts	0.6	0.7	2.5	0.6	1.6	0.0	-0.0
Total sessions with >9 infusions	1.8	2.0	3.1	1.2	0.6	-1.7	-1.8
Short access day 1 total inactive lever presses	0.6	0.7	1.9	0.4	1.4	-0.6	-0.6
Short access day 10 total inactive lever presses	1.2	1.4	2.5	-1.6	-1.4	-0.7	-0.7
Short access day 1 total infusions	1.7	1.8	2.0	1.3	1.2	-1.4	-1.4
Short access day 10 total infusions	1.2	1.3	3.0	1.7	1.2	-0.6	-0.6
Short access total infusions	1.8	2.1	3.2	1.8	1.3	-1.3	-1.3
Short access day 1 locomotion	0.6	0.6	0.8	0.9	0.7	-0.8	-0.9
Short access day 10 total locomotion	0.4	0.5	0.8	0.9	0.9	-0.4	-0.4
Short access total locomotion	3.4	3.5	4.3	2.1	1.3	-2.0	-2.0
One hour access (0.3 mA shock)	0.1	0.1	0.3	0.4	0.6	0.3	0.3
Compulsive drug intake	0.1	0.1	0.4	-0.6	0.2	-0.1	0.0
One hour access (shock baseline)	0.4	0.4	1.1	1.0	0.8	-0.2	-0.3
Social response proportion	0.2	0.2	0.7	-0.9	0.2	-0.1	-0.1
Social responses	2.1	2.7	4.7	-2.2	-1.5	1.4	1.3
Social time	0.2	0.2	0.3	-0.5	-0.3	0.5	0.6
Soleus weight	1.4	4.0	10.0	-2.5	-3.2	-0.1	-0.1
Bone: stiffness	1.4	2.3	5.0	-2.2	-2.0	0.3	0.3
Tibialis anterior weight	0.2	0.8	1.5	-1.2	-1.0	0.7	0.6
Time to tail flick, vehicle, before self-admin	0.5	0.5	0.8	-0.9	-0.1	0.8	0.8
Time to tail flick, vehicle, after self-admin	0.5	0.5	0.6	-0.7	-0.8	0.7	0.7
Time to tail flick, test, before self-admin	1.9	1.9	2.3	1.5	0.9	-1.5	-1.5
Time to tail flick, test, after self-admin	0.6	0.6	0.9	-0.8	-0.2	0.9	0.9
Delta time to tail flick, vehicle, before/after SA	1.3	1.3	3.5	-0.8	-1.9	0.7	0.7
Delta time to tail flick, test, before/after SA	3.8	3.4	4.9	-2.2	-1.1	2.0	2.0
Tibia length	0.2	0.5	1.2	-1.1	-0.8	0.3	0.4
Ambulatory time before self-admin	1.6	1.7	2.6	1.3	-0.0	-1.6	-1.6
Ambulatory time after self-admin	3.0	3.3	4.3	2.1	1.7	-1.7	-1.7
Bone: tissue strength	0.2	0.2	0.3	0.3	0.5	0.5	0.5
Total heroin consumption	3.5	4.1	7.4	-2.3	-2.7	1.3	1.3
Bone: trabecular number	1.6	2.5	5.1	-2.2	-1.4	1.2	1.2
Bone: trabecular spacing	1.4	1.9	4.2	1.8	2.0	-0.2	-0.2
Bone: trabecular thickness	7.9	9.5	16.7	-4.1	-3.9	1.7	1.7
Bone: trabecular tissue density	1.5	2.1	3.9	1.5	2.0	-1.1	-1.1
Water consumed over 24 hours	0.1	0.2	0.3	-0.1	-0.4	-0.5	-0.5
Number of responses in last shaping day	0.7	0.7	1.1	1.1	1.0	-0.6	-0.6