Hub : Genes

Shoc2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose intron excision ratio chr1_252996911_253013782 0.04 0.02 3.7e-04 0.01 0.03 0.01 0.01 8.2e-03 7.4e-04 3.0e-02 1.2e-02
2 NAcc intron excision ratio chr1_252996911_253013782 0.03 0.02 6.0e-03 0.01 0.01 0 0 2.9e-02 5.6e-02 3.4e-01 7.1e-02
3 PL intron excision ratio chr1_252996911_253013782 0.04 0.02 1.2e-03 0.03 0.02 0.02 0.03 1.1e-04 3.2e-03 1.5e-03 8.9e-04
4 Brain alternative polyA XM_039080784.1 0.04 0.03 3.2e-03 0.01 0.02 0.01 0.01 1.6e-02 8.9e-03 8.3e-02 1.5e-02
5 NAcc intron excision ratio chr1_253013919_253026947 0.03 0.02 7.4e-03 0 0.01 0.01 0 7.4e-02 2.7e-02 3.7e-02 1.2e-01
6 Adipose mRNA stability Shoc2 0.08 0.04 5.4e-09 0.06 0.06 0.07 0.06 7.2e-07 2.7e-07 3.6e-08 1.8e-07
7 NAcc gene expression Shoc2 0.06 0.05 6.5e-03 -0 0.01 0.01 0 9.3e-01 2.9e-02 4.4e-02 2.0e-01
8 Brain alternative polyA XM_039080757.1 0.03 0.02 7.6e-03 0.01 0.01 0 0.01 1.9e-02 2.8e-02 1.1e-01 2.9e-02
9 Brain alternative polyA XM_039080784.1 0.04 0.03 4.7e-03 0.02 0.01 0.01 0.02 1.0e-02 1.4e-02 6.1e-02 1.2e-02
10 Liver alternative polyA XM_039080784.1 0.03 0.02 2.5e-03 0.01 0 -0 0 2.8e-02 8.1e-02 4.3e-01 7.5e-02
11 Brain alternative TSS XM_039080768.1 0.04 0.03 8.6e-04 0.01 0.04 0.04 0.03 1.2e-02 2.6e-04 3.3e-04 1.5e-03
12 Liver alternative polyA XM_039080757.1 0.03 0.02 9.0e-03 0 0 -0 -0 8.5e-02 2.7e-01 7.9e-01 3.8e-01
13 PL alternative TSS XM_039080752.1 0.04 0.03 6.0e-03 0.01 0.01 0.01 0 4.8e-02 1.1e-02 1.7e-02 3.2e-01
14 Brain mRNA stability Shoc2 0.04 0.03 2.9e-03 0.01 0.03 0.02 0.02 5.3e-02 1.7e-03 8.3e-03 9.1e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density1.52.54.52.0-2.0-2.0-2.1-1.8-1.52.0-2.02.00.80.3-0.6-0.1-0.7
Area under the delay curve1.92.05.21.7-1.5-1.5-1.8-1.7-2.32.0-1.41.40.40.5-0.6-0.4-0.8
BMI with tail2.27.313.13.4-2.9-2.9-3.2-2.6-3.62.0-3.33.32.5-1.1-2.71.70.4
BMI without tail2.96.011.42.9-3.1-3.1-3.0-2.9-3.42.9-2.42.41.9-0.7-1.80.2-0.1
Body weight3.514.629.94.6-4.4-4.4-4.8-3.5-4.02.2-5.55.53.1-1.7-3.12.50.0
Weight adjusted by age0.80.92.10.9-1.5-1.5-1.1-0.8-0.9-0.3-1.31.30.6-0.9-0.50.7-0.1
Bone surface0.20.40.70.9-0.7-0.7-0.8-0.6-0.20.6-0.80.80.7-0.1-0.40.50.2
Bone volume1.42.35.31.9-1.8-1.8-2.0-1.5-1.31.4-2.32.30.9-0.1-0.70.5-0.5
Breakpoint value in progressive ratio session0.80.82.51.0-1.4-1.4-1.0-1.0-0.11.6-0.80.80.00.6-0.0-0.7-0.7
Number of licking bursts0.70.82.80.6-0.8-0.8-0.8-0.1-0.20.6-1.71.7-0.71.00.4-0.3-1.3
Context. condit. distance diff. score0.91.12.3-1.51.11.11.51.41.3-0.91.0-1.0-1.00.40.7-0.30.2
Locomotion velocity, session 11.41.53.0-1.21.01.01.00.90.6-0.30.8-0.8-1.61.71.7-1.7-1.6
Locomotion distance, session 10.40.51.2-0.80.90.90.81.10.7-1.00.1-0.1-0.50.10.40.30.1
Locomotion velocity, session 20.80.92.6-0.91.01.01.01.01.0-1.60.4-0.40.5-1.1-0.11.21.3
Locomotion distance, session 20.40.51.2-0.20.20.20.10.90.6-1.1-1.11.1-0.50.60.80.7-0.6
Locomotion velocity, session 31.01.22.5-1.51.21.21.31.61.0-1.40.3-0.3-1.50.81.0-0.3-0.6
Locomotion distance, session 32.02.14.2-2.01.61.61.62.11.6-1.9-0.10.1-1.90.91.7-0.5-1.0
Stereotopy head waving bouts, day 30.20.21.00.20.30.30.1-0.20.00.01.0-1.00.20.0-0.10.10.4
Stereotopy head waving duration, day 30.40.42.3-0.10.50.50.3-0.10.00.41.5-1.5-0.20.50.2-0.60.0
Locomotion velocity, session 70.70.81.8-0.90.70.70.70.90.8-0.80.2-0.2-1.31.11.3-0.8-1.2
Locomotion distance, session 71.21.63.5-1.61.41.41.51.91.7-1.70.2-0.2-1.20.61.20.1-0.3
Stereotopy head waving bouts, day 70.50.51.1-0.60.80.80.60.60.4-0.50.7-0.7-0.90.91.0-0.7-0.8
Stereotopy head waving duration, day 70.30.41.1-0.20.30.30.20.2-0.0-0.20.5-0.5-0.81.10.9-0.8-1.0
Locomotion velocity, session 80.20.20.7-0.70.50.50.70.70.5-0.80.4-0.4-0.2-0.10.10.20.3
Locomotion distance, session 80.71.02.6-1.41.01.01.31.61.5-1.40.1-0.1-1.00.30.70.30.0
Degree of sensitization distance0.30.30.90.5-0.5-0.5-0.3-0.7-0.11.00.7-0.70.50.1-0.2-0.20.3
Degree of sensitization stereotypy1.01.12.3-1.01.01.01.01.20.9-0.90.5-0.5-1.41.41.5-0.7-1.1
Conditioned locomotion0.91.02.6-1.21.01.01.11.61.4-1.6-0.00.0-0.90.51.20.3-0.4
Cocaine response after cond. corrected1.51.75.2-1.31.51.51.61.01.1-0.52.3-2.3-0.4-0.10.2-0.31.0
Cocaine response after cond. not corrected2.52.76.6-1.91.91.92.21.71.8-1.12.6-2.6-0.80.10.4-0.21.1
Cocaine response before conditioning0.30.31.2-0.60.30.30.70.81.1-0.70.4-0.4-0.60.50.40.0-0.1
Saline control response0.91.22.5-1.11.21.21.31.11.6-1.51.5-1.5-0.4-0.00.70.30.5
Bone: connectivity density0.40.61.50.8-0.8-0.8-0.8-1.0-0.61.2-0.60.60.9-0.4-0.70.00.3
Bone: cortical apparent density1.62.16.2-1.82.02.01.71.81.3-2.50.9-0.9-0.5-1.00.30.70.8
Bone: cortical area0.60.92.60.10.10.10.01.01.3-0.9-1.01.0-1.01.61.20.7-1.1
Bone: cortical porosity0.30.30.90.8-0.5-0.5-0.6-0.8-0.11.00.5-0.5-0.00.80.3-0.5-0.4
Bone: cortical porosity0.40.41.00.8-0.8-0.8-0.7-0.7-0.11.0-0.00.0-0.21.00.4-0.6-0.8
Bone: cortical thickness1.32.15.6-1.01.31.31.22.32.4-2.3-0.30.3-1.31.21.41.2-0.4
Bone: cortical thickness1.11.33.9-0.81.21.21.01.81.6-2.0-0.40.4-0.80.50.81.3-0.0
Bone: cortical tissue density1.52.05.8-1.82.02.01.71.71.2-2.40.9-0.9-0.4-1.10.30.70.8
Condit. Reinf. active minus inactive responses1.31.43.1-1.10.80.81.00.81.0-0.01.0-1.0-1.61.71.5-1.8-1.4
Condit. Reinf. active-inactive response ratio0.80.82.3-0.70.50.50.80.30.50.51.3-1.3-1.01.20.8-1.5-0.7
Condit. Reinf. active responses1.61.95.8-1.00.70.70.90.91.1-0.20.7-0.7-2.02.42.0-1.8-2.0
Condit. Reinf. inactive responses0.50.62.90.0-0.1-0.1-0.00.30.40.1-0.20.2-1.11.71.1-0.8-1.5
Incentive salience index mean1.51.84.4-1.40.80.81.10.91.00.01.1-1.1-1.91.81.7-2.1-1.6
Condit. Reinf. lever presses0.50.72.6-0.6-0.1-0.10.20.10.10.4-0.10.1-1.31.11.0-1.6-1.5
Condit. Reinf. active minus inactive responses3.94.814.0-1.20.90.90.90.51.00.71.5-1.5-3.13.73.0-3.7-3.4
Condit. Reinf. active-inactive response ratio3.73.99.6-1.61.01.01.41.01.10.31.9-1.9-2.73.02.4-3.1-2.5
Condit. Reinf. active responses2.63.711.3-0.80.60.60.50.30.80.60.8-0.8-2.73.42.7-3.2-3.3
Condit. Reinf. inactive responses0.40.52.20.2-0.1-0.1-0.4-0.3-0.10.3-0.50.5-0.81.11.0-1.1-1.5
Condit. Reinf. lever presses2.63.58.9-1.61.11.11.31.51.5-0.50.8-0.8-2.83.02.7-2.3-2.7
Condit. Reinf. lever reinforcers received2.83.911.7-1.00.80.80.80.61.10.51.2-1.2-2.83.42.7-3.2-3.1
Conditioned reinforcement - actives1.01.02.31.2-1.5-1.5-1.0-1.4-0.51.40.0-0.01.1-0.5-0.7-0.10.4
Conditioned reinforcement - inactives0.60.61.20.9-1.1-1.1-1.1-0.8-0.40.6-0.70.7-0.10.60.7-0.4-1.1
Conditioned locomotion2.73.35.52.1-1.9-1.9-1.9-1.9-2.01.3-1.21.22.3-1.9-2.31.51.4
Patch foraging indifference point 0 sec0.60.92.90.21.11.10.61.01.2-1.01.0-1.00.10.50.01.71.0
Patch foraging indifference point AUC0.91.03.1-0.10.50.5-0.10.61.3-0.3-0.90.9-1.41.81.4-0.4-1.7
Delay disc. indifference point, 0s delay1.31.43.11.3-1.7-1.7-1.5-1.3-1.70.9-1.21.20.5-0.1-0.3-0.0-0.6
Delay disc. indifference point, 16s delay0.60.62.10.9-0.4-0.4-0.8-1.0-1.31.4-0.40.40.10.5-0.3-0.6-0.5
Delay disc. indifference point, 2s delay0.70.81.70.8-1.3-1.3-1.1-0.8-1.30.7-1.31.30.1-0.1-0.2-0.2-0.6
Delay disc. indifference point, 24s delay2.22.15.21.8-1.4-1.4-1.9-1.7-2.32.0-1.61.60.40.7-0.2-0.5-0.9
Delay disc. indifference point, 4s delay0.80.82.20.7-0.5-0.5-0.9-0.9-1.51.4-0.90.9-0.30.70.1-1.1-1.2
Delay disc. indifference point, 8s delay2.32.44.62.0-1.7-1.7-1.9-1.8-2.12.2-1.61.60.60.4-1.0-0.1-0.5
Indifference point function ln k0.20.30.9-0.0-0.2-0.20.1-0.3-0.8-0.10.7-0.70.6-1.0-0.70.30.9
Indifference point function log k0.20.30.9-0.0-0.2-0.20.1-0.3-0.8-0.10.7-0.70.6-1.0-0.70.30.9
Patch foraging total patch changes 0 sec0.40.61.90.20.90.90.50.91.2-0.90.7-0.7-0.10.90.41.40.5
Patch foraging total patch changes 12 sec0.60.82.70.10.70.70.00.71.5-0.2-0.40.4-1.11.61.20.1-1.1
Patch foraging total patch changes 18 sec0.91.15.00.10.80.80.10.81.4-0.50.0-0.0-1.42.21.6-0.1-1.5
Patch foraging total patch changes 24 sec0.70.94.60.8-0.0-0.0-0.60.10.30.6-0.90.9-1.02.11.0-0.2-1.5
Patch foraging total patch changes 6 sec0.40.62.20.50.80.80.10.91.3-0.6-0.20.2-0.11.00.51.50.2
Patch foraging time to switch 0 sec0.50.71.70.5-0.9-0.9-0.4-1.1-0.91.30.5-0.51.1-1.1-1.0-0.21.0
Patch foraging water rate 0 sec0.20.31.3-0.10.50.50.10.70.4-1.1-0.50.5-0.50.60.50.6-0.6
Patch foraging water rate 12 sec0.40.62.11.2-0.7-0.7-1.0-0.9-1.40.8-0.70.70.60.1-0.60.3-0.0
Patch foraging water rate 18 sec0.20.30.80.5-0.1-0.1-0.3-0.3-0.90.1-0.30.30.7-0.6-0.90.80.7
Patch foraging water rate 24 sec0.40.61.31.0-0.6-0.6-0.9-0.6-1.10.6-1.01.00.5-0.2-1.00.70.2
Patch foraging water rate 6 sec0.30.41.30.6-0.3-0.3-0.4-0.3-0.6-0.6-0.20.20.9-0.7-0.71.20.7
Seeking ratio, delayed vs. immediate footshock0.50.62.00.7-0.1-0.1-0.4-0.1-0.8-0.1-0.60.60.8-0.9-1.11.41.0
Distance traveled before self-admin1.21.24.1-1.51.21.21.31.41.1-2.00.6-0.6-0.1-1.00.40.60.8
Distance traveled after self-admin1.51.65.90.2-0.2-0.2-0.10.0-0.7-1.2-0.60.61.6-2.4-1.52.22.1
Extensor digitorum longus weight0.51.96.40.5-0.8-0.8-1.1-0.3-0.60.2-2.42.4-1.21.31.1-0.9-2.5
Bone: elastic displacement0.10.10.40.3-0.3-0.3-0.3-0.5-0.60.60.2-0.2-0.00.1-0.0-0.5-0.3
Bone: elastic work0.40.50.80.7-0.8-0.8-0.8-0.5-0.9-0.1-0.90.90.5-0.8-0.70.80.2
Bone: endosteal estimation1.43.05.52.3-2.3-2.3-2.2-2.1-1.62.2-1.51.51.3-0.3-1.40.40.1
Bone: endosteal perimeter0.81.64.51.5-1.6-1.6-1.6-1.0-0.80.7-2.12.10.60.0-0.40.7-0.5
Epididymis fat weight3.78.720.63.3-3.7-3.7-3.7-2.6-3.22.0-4.54.51.00.4-1.20.3-2.0
Delta time in closed arm before/after self-admin1.11.03.1-0.90.90.91.10.81.3-0.81.8-1.80.1-0.50.30.51.1
Delta time in open arm before/after self-admin1.01.02.11.2-1.3-1.3-1.3-1.3-1.51.1-0.80.80.20.5-0.2-0.5-0.9
Diff in mean of infusions in LGA sessions1.82.04.1-1.81.11.11.81.21.2-0.12.0-2.0-1.71.20.7-1.7-0.4
Delay discount exponential model param2.12.25.6-1.81.51.51.91.72.4-2.01.6-1.6-0.4-0.50.60.50.9
Extinction: sum of active levers before priming0.20.20.40.3-0.4-0.4-0.1-0.30.50.60.6-0.6-0.30.60.2-0.4-0.1
Active lever presses in extinction session 60.50.51.4-0.60.60.60.30.80.1-0.8-0.50.5-0.90.81.2-0.2-1.0
Bone: final force0.30.51.81.1-0.5-0.5-0.7-0.30.10.3-0.90.90.6-0.1-0.91.30.6
Bone: final moment0.50.82.01.4-0.8-0.8-1.0-0.6-0.20.6-1.01.00.8-0.1-1.01.30.5
Food consumed during 24 hour testing period0.30.40.90.8-0.7-0.7-0.8-0.9-0.40.9-0.40.40.7-0.4-0.40.20.4
Glucose2.03.09.61.5-2.0-2.0-1.8-0.8-1.5-0.1-3.13.11.1-1.1-1.11.7-0.1
Heart weight4.26.09.9-2.53.13.12.93.02.6-2.72.5-2.5-2.31.92.2-0.4-0.7
Delay discount hyperbolic model param1.81.95.0-1.61.41.41.81.62.2-1.91.6-1.6-0.3-0.40.60.50.8
Intermittent access intake day 1-15 change2.52.55.32.2-2.3-2.3-2.1-2.3-1.42.0-1.01.01.10.0-0.3-0.3-0.4
Intermittent access intake escalation2.32.24.32.1-2.1-2.1-2.0-2.0-1.51.6-1.11.11.4-0.4-0.50.2-0.0
Intermittent access intake escalation 23.73.67.22.4-2.7-2.7-2.4-2.5-1.81.9-1.71.71.7-0.9-1.30.40.1
Intermitt. access day 1 inactive lever presses1.41.54.50.8-0.9-0.9-1.1-0.3-1.00.6-2.12.1-1.21.30.5-0.4-1.9
Intermitt. access day 15 inactive lever presses0.20.30.8-0.1-0.3-0.3-0.1-0.1-0.90.6-0.40.4-0.60.50.1-0.8-0.8
Intermitt. access escalation Index0.70.61.20.7-1.0-1.0-0.8-0.6-0.90.1-1.11.10.7-0.9-0.50.80.4
Intermittent access day 1 total infusions0.60.71.80.6-0.8-0.8-0.7-0.8-0.71.3-0.30.3-0.61.20.5-1.2-1.2
Intermittent access day 15 total infusions2.62.96.22.0-2.3-2.3-2.1-2.2-2.12.5-1.21.20.30.8-0.0-1.0-1.3
Intermittent access terminal intake (last 3 days)3.43.77.72.2-2.6-2.6-2.4-2.5-2.42.8-1.61.60.60.5-0.7-1.0-1.2
Intermittent access total infusions2.32.55.31.9-2.1-2.1-2.0-2.0-2.02.3-1.31.30.30.8-0.2-0.9-1.2
Intermittent access day 1 locomotion0.10.10.60.1-0.2-0.2-0.2-0.3-0.80.2-0.20.20.1-0.4-0.7-0.00.1
Intermittent access day 15 total locomotion0.80.92.81.2-0.9-0.9-1.3-1.2-1.70.7-0.90.90.50.1-0.00.0-0.5
Intermittent access total locomotion0.91.03.11.1-0.9-0.9-1.0-1.1-1.70.5-0.70.71.0-1.1-1.20.70.6
Intermittent access standard deviation4.95.210.23.1-3.2-3.2-3.0-3.0-2.13.1-1.91.91.70.3-0.6-0.3-0.7
Left kidney weight2.26.115.42.1-1.6-1.6-1.8-1.2-1.9-0.6-2.22.23.3-3.6-3.33.92.8
Right kidney weight1.54.28.52.1-1.7-1.7-1.9-1.2-1.6-0.0-2.42.42.5-2.4-2.62.91.7
Cocaine induced anxiety2.22.56.8-1.71.61.61.82.11.4-2.60.5-0.50.4-1.7-0.61.91.9
Post-drug Anxiety0.80.81.9-0.81.21.21.11.40.4-1.30.1-0.10.1-0.6-0.71.31.0
Baseline Anxiety1.71.85.71.1-0.9-0.9-1.3-0.9-1.21.4-1.11.1-1.22.20.8-1.5-2.4
Tail length0.51.53.11.0-1.7-1.7-1.5-1.2-0.81.2-1.81.8-0.10.30.5-0.7-1.3
Length with tail1.24.312.82.3-2.4-2.4-2.7-1.7-1.40.7-3.63.61.2-0.9-1.11.4-0.4
Length without tail0.81.85.81.4-0.6-0.6-1.3-0.2-0.1-1.1-2.42.40.8-0.8-1.02.30.2
Times rat made contact with spout0.40.41.90.40.20.2-0.50.20.3-0.8-1.41.4-0.10.30.20.8-0.5
Lifetime Intake2.12.35.11.9-2.1-2.1-1.9-2.0-1.72.3-1.01.00.50.8-0.1-0.9-1.0
Liver weight, left0.40.62.10.50.10.1-0.60.10.3-0.1-1.21.2-0.51.41.0-0.1-1.4
Liver weight, right4.27.013.53.4-3.0-3.0-3.6-2.8-2.41.7-3.73.72.3-1.2-1.81.6-0.1
Locomotor activity0.71.13.1-0.81.51.51.01.31.0-1.80.3-0.30.0-0.50.01.40.9
Locomotor testing distance1.11.84.9-0.81.51.51.21.51.1-2.20.8-0.80.6-1.2-0.52.01.7
Locomotor testing rearing0.50.83.00.00.80.80.40.30.0-0.70.6-0.61.1-1.2-0.91.51.7
Locomotion in novel chamber1.41.83.4-1.41.51.51.61.41.5-1.71.8-1.8-0.4-0.20.60.40.8
Locomotion in novel chamber post-restriction0.10.10.3-0.30.00.00.3-0.1-0.50.10.6-0.6-0.1-0.4-0.6-0.50.1
Fecal boli incidents, locomotor time 10.50.61.00.8-1.0-1.0-1.0-1.0-0.70.6-1.01.00.5-0.4-0.4-0.0-0.1
Change in fecal boli incidents, locomotor task0.50.51.7-0.80.00.00.50.30.10.00.7-0.7-1.00.70.9-1.3-0.9
Time >=10cm from walls, locomotor time 10.30.31.40.0-0.4-0.40.1-0.20.1-0.10.6-0.61.0-0.9-0.20.61.2
Bouts of movement, locomotor time 11.92.14.71.8-2.1-2.1-1.9-2.2-1.22.0-0.50.50.40.7-0.1-1.2-1.1
Total resting periods, locomotor time 12.02.24.61.8-2.1-2.1-2.0-2.2-1.31.9-0.90.90.40.7-0.0-1.1-1.2
Rest time, locomotor task time 10.30.31.2-0.70.60.60.70.70.7-1.10.4-0.4-0.20.20.60.10.0
Distance moved, locomotor task time 10.80.91.80.9-1.1-1.1-1.1-0.9-1.30.9-1.31.30.3-0.4-0.60.1-0.3
Vertical activity count, locomotor time 10.90.92.2-1.51.01.01.31.21.2-1.20.8-0.8-0.7-0.30.4-0.20.2
Time >=10cm from walls, locomotor time 20.30.31.2-0.50.50.50.51.00.5-1.1-0.30.3-0.50.50.60.4-0.3
Bouts of movement, locomotor time 20.91.03.60.6-0.6-0.6-1.0-1.7-1.11.80.2-0.2-0.10.2-0.0-1.9-0.8
Total resting periods, locomotor time 20.90.93.40.9-0.7-0.7-1.1-1.8-0.91.90.2-0.20.30.0-0.2-1.5-0.5
Rest time, locomotor task time 21.01.14.20.9-0.7-0.7-0.6-0.8-0.20.20.1-0.12.1-1.5-1.11.41.8
Distance moved, locomotor task time 20.50.62.0-0.50.50.50.40.60.30.20.2-0.2-1.41.41.0-0.9-1.2
Vertical activity count, locomotor time 21.61.83.5-1.51.71.71.41.91.3-1.60.2-0.2-1.71.11.3-0.2-0.8
Light reinforcement 10.81.52.8-1.51.71.71.51.31.4-0.81.3-1.3-1.30.81.0-0.8-0.4
Light reinforcement 20.60.91.7-1.21.01.01.00.91.1-0.60.6-0.6-1.30.61.0-1.0-0.7
Bone: marrow area1.32.95.52.4-2.3-2.3-2.2-2.1-1.52.1-1.51.51.3-0.3-1.40.40.1
Bone: maximum diameter0.51.02.50.6-0.6-0.6-0.60.50.8-0.6-1.51.5-0.91.61.00.5-1.4
Bone: maximum force0.10.20.60.8-0.5-0.5-0.5-0.10.40.2-0.50.50.20.2-0.30.80.2
Bone: maximum moment0.20.41.21.1-0.9-0.9-0.8-0.50.10.5-0.70.70.40.3-0.40.70.1
Mean time between licks in bursts0.81.24.30.6-0.7-0.7-0.5-1.3-1.32.11.1-1.1-0.21.0-0.1-1.8-0.7
Mean num. licks in bursts0.60.71.8-0.10.90.90.40.20.3-1.10.8-0.81.0-1.2-0.61.21.3
Cd content in liver5.15.612.8-2.43.13.12.92.22.3-1.13.6-3.6-1.51.31.4-0.90.5
Co content in liver1.41.63.3-0.91.81.81.31.11.1-1.61.4-1.40.3-0.9-0.41.21.5
Cu content in liver0.60.72.10.9-0.2-0.2-1.0-0.9-1.50.3-0.90.91.0-1.0-0.90.70.5
Fe content in liver1.61.95.6-1.12.42.41.41.61.7-1.51.1-1.1-0.90.60.80.60.3
K content in liver1.61.62.91.4-1.3-1.3-1.7-1.6-1.71.3-1.51.50.8-0.5-0.7-0.1-0.4
Mg content in liver1.81.93.51.4-1.5-1.5-1.8-1.5-1.51.6-1.91.90.20.3-0.1-0.7-1.3
Mn content in liver0.80.91.9-1.20.60.60.91.00.7-0.90.2-0.2-1.40.81.4-1.0-1.1
Na content in liver0.80.93.6-0.40.40.40.0-0.2-0.00.60.1-0.1-1.21.31.4-1.9-1.7
Rb content in liver0.50.62.90.4-0.2-0.2-0.3-0.8-0.41.70.8-0.8-0.21.00.3-1.5-0.6
Se content in liver0.20.20.60.4-0.0-0.0-0.2-0.6-0.50.60.5-0.50.6-0.5-0.70.10.7
Sr content in liver1.41.22.70.6-0.7-0.7-0.7-1.6-1.61.20.8-0.81.3-1.6-1.3-0.41.1
Zn content in liver0.50.61.6-1.31.11.10.80.60.2-0.80.4-0.4-0.7-0.40.7-0.7-0.2
Bone: minimum diameter0.50.92.21.0-1.1-1.1-1.1-0.5-0.40.6-1.51.5-0.40.80.2-0.1-1.1
Time in familiar zone, hab. session 11.00.92.90.2-0.4-0.4-0.0-0.6-1.00.20.8-0.81.3-1.7-1.60.71.6
Time in novel zone, hab. session 11.21.24.10.2-0.4-0.4-0.50.10.40.2-1.51.5-1.31.61.3-0.9-2.0
Total zone transitions, hab. session 10.71.03.0-0.81.01.00.71.51.1-1.7-0.50.5-0.90.81.10.6-0.7
Total locomotion distance, hab. session 10.30.41.2-0.30.20.20.30.70.8-0.7-0.10.1-0.91.01.1-0.1-0.9
Locomotion velocity, hab. session 10.50.71.9-0.60.60.60.61.01.1-0.90.3-0.3-1.01.21.4-0.2-0.8
Time in familiar zone, hab. session 21.81.83.91.3-1.7-1.7-1.6-1.4-1.32.0-1.21.2-0.21.10.1-1.2-1.5
Time in novel zone, hab. session 21.11.12.2-0.91.31.31.21.10.9-1.50.9-0.90.1-0.9-0.21.01.2
Total zone transitions, hab. session 20.20.20.5-0.0-0.0-0.0-0.00.40.4-0.4-0.60.6-0.60.70.50.1-0.7
Total locomotion distance, hab. session 20.20.30.9-0.1-0.1-0.1-0.00.50.5-0.5-0.60.6-0.90.80.8-0.1-1.0
Locomotion velocity, hab. session 20.30.40.9-0.30.10.10.20.70.8-0.8-0.40.4-0.90.80.9-0.0-0.9
Novel to familiar place preference ratio0.40.41.20.8-1.1-1.1-0.7-0.8-0.51.0-0.20.20.30.3-0.3-0.3-0.2
Novelty place preference0.91.02.31.2-1.5-1.5-1.2-1.2-1.01.4-0.60.60.60.1-0.6-0.2-0.2
Time in novel zone, NPP test1.41.53.31.5-1.8-1.8-1.5-1.5-1.21.8-0.80.80.50.3-0.5-0.5-0.5
Total zone transitions, NPP test0.60.81.8-0.40.10.10.21.00.8-0.8-1.21.2-1.01.31.3-0.0-1.3
Total locomotion distance, NPP test0.50.71.9-0.2-0.0-0.00.00.70.7-0.6-0.80.8-1.01.31.3-0.3-1.4
Locomotion velocity, NPP test0.40.51.2-0.50.20.20.40.91.0-1.0-0.60.6-0.80.81.10.1-0.8
Intraocular pressure0.60.82.50.9-0.7-0.7-0.9-0.7-0.41.4-0.50.5-0.41.60.6-0.8-1.3
Delta distance traveled before/after self-admin2.42.65.11.9-1.5-1.5-1.4-1.5-2.11.0-0.70.72.1-1.6-2.31.71.7
Delta ambulatory time before/after self-admin2.02.23.92.0-1.6-1.6-1.6-1.6-2.01.5-1.01.01.6-0.8-1.91.00.9
Parametrial fat weight1.42.85.62.4-1.9-1.9-2.4-1.9-1.61.6-2.22.20.70.5-0.70.1-1.1
Pavlov. Cond. lever latency0.00.10.20.20.20.20.10.20.20.10.2-0.20.10.3-0.10.50.3
Pavlov. Cond. magazine entry latency0.40.51.20.5-1.0-1.0-0.8-0.5-0.50.5-1.11.1-0.20.2-0.0-0.2-0.7
Pavlov. Cond. change in total contacts0.30.31.30.1-0.7-0.7-0.5-0.2-0.3-0.2-1.11.1-0.0-0.5-0.20.1-0.3
Pavlov. Cond. index score0.30.41.40.2-0.8-0.8-0.6-0.4-0.4-0.1-1.21.2-0.1-0.20.0-0.1-0.6
Pavlov. Cond. latency score0.30.41.20.3-0.8-0.8-0.6-0.5-0.50.0-1.11.10.0-0.4-0.2-0.1-0.4
Pavlov. Cond. lever contacts0.30.30.80.1-0.7-0.7-0.5-0.6-0.70.4-0.50.5-0.3-0.10.1-0.9-0.7
Pavlov. Cond. magazine entry number0.50.71.8-0.81.01.01.00.70.8-0.31.3-1.3-0.20.20.4-0.20.5
Pavlov. Cond. intertrial magazine entries0.50.61.1-0.81.11.10.91.10.9-0.90.4-0.4-0.70.60.70.1-0.3
Pavlov. Cond. lever-magazine prob. diff.0.30.41.40.2-0.7-0.7-0.6-0.3-0.4-0.0-1.21.2-0.3-0.00.2-0.3-0.9
Pavlov. Cond. response bias0.40.41.10.4-0.9-0.9-0.8-0.6-0.70.3-1.11.10.1-0.3-0.2-0.2-0.5
Pavlov. Cond. lever latency2.12.89.70.9-0.7-0.7-0.7-1.1-1.1-0.1-0.10.12.6-3.1-2.32.12.7
Pavlov. Cond. magazine entry latency0.70.81.51.2-0.9-0.9-1.2-0.9-0.91.1-1.01.0-0.10.90.3-0.4-1.1
Pavlov. Cond. change in total contacts1.31.76.80.1-0.2-0.2-0.2-0.10.30.80.0-0.0-1.82.61.8-2.0-2.5
Pavlov. Cond. index score0.91.15.00.3-0.2-0.2-0.3-0.00.10.7-0.30.3-1.42.21.4-1.3-2.0
Pavlov. Cond. latency score0.91.14.10.6-0.5-0.5-0.6-0.3-0.10.9-0.60.6-1.12.01.2-1.2-2.0
Pavlov. Cond. lever contacts2.02.77.6-1.21.01.01.11.51.5-0.70.2-0.2-2.62.72.4-1.6-2.4
Pavlov. Cond. magazine entry number0.91.11.9-1.31.21.21.41.11.1-1.31.2-1.20.1-1.0-0.20.51.2
Pavlov. Cond. intertrial magazine entries0.70.91.6-1.21.21.21.21.21.3-0.90.8-0.8-0.80.40.7-0.20.0
Pavlov. Cond. lever-magazine prob. diff.0.81.14.30.3-0.4-0.4-0.4-0.1-0.00.6-0.40.4-1.32.11.4-1.3-2.0
Pavlov. Cond. response bias1.52.07.5-0.70.70.70.71.00.9-0.20.2-0.2-2.22.72.1-1.5-2.3
Time in closed arm before self-admin0.30.42.00.2-0.3-0.3-0.5-0.3-0.50.0-1.41.40.0-0.3-0.4-0.1-0.4
Time in closed arm after self-admin0.30.31.0-0.70.20.20.50.10.40.31.0-1.0-0.4-0.10.3-0.90.0
Time in open arm before self-admin0.30.40.9-0.70.70.70.60.81.0-0.60.2-0.2-0.60.20.9-0.0-0.2
Time in open arm after self-admin0.50.51.30.8-0.8-0.8-0.8-0.7-1.20.7-0.50.5-0.10.80.2-0.4-0.9
Bone: periosteal estimation0.71.43.21.8-1.6-1.6-1.6-0.9-0.40.8-1.71.70.50.5-0.50.9-0.4
Bone: periosteal perimeter0.81.45.21.4-1.1-1.1-1.4-0.3-0.1-0.2-2.32.30.20.50.01.3-0.7
Bone: post-yield work0.60.82.80.1-0.4-0.4-0.2-0.40.21.20.2-0.2-1.01.50.9-1.7-1.4
Progressive ratio test 1 active lever presses1.01.12.91.3-1.2-1.2-1.2-1.6-1.71.6-0.20.20.6-0.0-0.5-0.4-0.2
Progressive ratio test 1 breakpoint0.80.82.61.0-1.0-1.0-1.0-1.3-1.31.6-0.10.10.10.4-0.2-0.8-0.5
Progressive ratio test 1 inactive lever presses1.31.43.10.8-1.2-1.2-1.1-0.9-1.21.4-1.21.2-0.81.20.6-1.2-1.8
Progressive ratio test 2 active lever presses3.53.88.82.5-2.6-2.6-2.3-2.8-2.53.0-0.80.81.5-0.2-1.2-0.5-0.0
Progressive ratio test 2 breakpoint3.33.79.02.4-2.6-2.6-2.3-2.8-2.43.0-0.70.71.30.0-1.1-0.7-0.2
Progressive ratio test 2 inactive lever presses3.43.98.32.1-2.7-2.7-2.3-2.4-2.62.9-1.81.80.50.3-1.0-1.0-1.1
Incentive Sensitization - Responses2.82.86.52.1-2.5-2.5-2.0-2.4-1.82.6-0.80.81.10.1-0.5-0.6-0.3
Incentive Sensitization - Breakpoint2.62.76.12.0-2.4-2.4-2.0-2.3-1.72.5-0.90.91.00.2-0.5-0.6-0.4
Sum of active levers in priming session hrs 5-60.20.20.8-0.50.40.40.30.5-0.3-0.5-0.20.2-0.60.50.9-0.4-0.7
Progressive ratio0.60.71.5-0.71.11.11.00.81.00.01.2-1.2-0.60.80.6-0.20.3
Food seeking constrained by brief footshock0.60.73.2-0.2-0.1-0.10.30.3-0.21.00.7-0.7-1.21.81.0-1.1-1.0
Seeking ratio, punishment vs. effort0.60.71.60.5-1.3-1.3-0.8-0.8-1.00.7-0.90.9-0.20.40.2-0.8-1.1
Retroperitoneal fat weight5.618.328.85.3-5.3-5.3-5.4-4.7-4.83.7-5.15.13.2-1.6-4.01.5-0.2
Reaction time number correct1.82.55.12.3-1.4-1.4-1.8-1.7-1.62.1-1.41.41.9-0.6-1.91.21.0
Reaction time mean minus median0.20.30.70.8-0.6-0.6-0.5-0.7-0.40.40.3-0.30.8-0.4-0.60.50.6
Reaction time mean minus median AUC0.91.12.41.2-1.3-1.3-1.0-1.2-1.00.6-0.20.21.6-1.2-1.20.91.0
Reaction time num false alarms0.70.92.6-0.80.40.40.40.60.9-0.4-0.30.3-1.41.31.5-1.2-1.6
Reaction time num false alarms AUC1.01.42.8-1.30.90.91.01.31.6-1.10.3-0.3-1.61.31.7-0.9-1.3
Reaction time trials correct on left1.82.55.12.3-1.4-1.4-1.8-1.7-1.62.1-1.41.41.9-0.6-1.91.21.0
Reaction time trials on left1.82.65.22.3-1.4-1.4-1.9-1.8-1.62.2-1.31.31.9-0.6-1.91.11.0
Reaction time mean0.40.51.50.4-0.4-0.4-0.2-0.5-0.7-0.00.3-0.31.1-1.2-1.00.81.2
Reaction time mean AUC0.30.41.10.2-0.3-0.3-0.0-0.4-0.60.10.6-0.60.9-1.0-0.90.41.0
Median of all reaction times0.50.72.40.3-0.3-0.3-0.1-0.4-0.7-0.20.1-0.11.2-1.5-1.21.01.4
Reaction time omissions1.01.44.61.2-1.3-1.3-0.9-1.6-1.32.20.7-0.71.3-0.6-1.1-0.40.8
Reaction time false alarm rate2.33.26.4-2.21.21.21.71.72.0-1.60.9-0.9-2.51.62.5-1.8-1.9
Reaction time premature initiation rate1.11.45.7-0.90.70.70.91.81.4-2.4-1.11.1-0.1-0.60.31.90.6
Reaction time premature initiations1.01.47.10.40.10.1-0.10.80.5-1.3-1.71.71.0-1.0-0.72.71.3
Std. dev. reaction times0.50.71.31.1-1.1-1.1-0.9-1.1-1.00.60.2-0.21.1-0.6-0.80.40.6
Reaction time trials completed1.82.65.22.3-1.4-1.4-1.9-1.8-1.62.2-1.31.31.9-0.6-1.91.11.0
Reaction time trials AUC1.82.65.32.3-1.3-1.3-1.9-1.8-1.72.1-1.41.41.9-0.6-1.81.10.9
Run reversals in cocaine runway, females1.41.44.91.1-0.5-0.5-0.5-0.7-0.40.40.2-0.21.8-1.4-1.71.82.2
Run reversals in cocaine runway, males0.20.20.5-0.70.60.60.70.60.5-0.10.4-0.4-0.3-0.10.0-0.20.2
Latency to leave start box in cocaine runway0.80.92.9-0.91.31.31.00.81.7-0.90.9-0.9-0.50.00.6-0.00.2
Latency to leave start box in cocaine runway, F2.52.86.4-1.72.52.51.91.82.0-2.01.7-1.7-0.4-0.50.50.71.1
Latency to leave start box in cocaine runway, M0.50.50.90.7-0.9-0.9-0.7-0.90.61.0-0.20.20.00.60.5-0.7-0.6
Std. dev. time between licks in bursts0.91.13.40.4-0.8-0.8-0.6-0.9-0.81.70.1-0.1-0.71.50.7-1.9-1.5
Total sessions with >9 infusions2.22.44.82.0-2.0-2.0-2.0-1.9-2.20.9-1.31.31.5-0.9-1.10.90.2
Short access day 1 total inactive lever presses1.51.63.81.6-2.0-2.0-1.8-1.5-1.21.1-1.31.30.6-0.1-0.20.0-0.7
Short access day 10 total inactive lever presses0.70.73.10.8-0.7-0.7-0.9-0.3-0.50.7-1.81.8-0.20.4-0.10.1-0.8
Short access day 1 total infusions2.72.95.22.1-2.3-2.3-2.2-2.1-1.91.4-1.51.51.8-1.0-1.10.70.2
Short access day 10 total infusions0.91.02.10.9-1.3-1.3-1.0-1.1-1.11.5-0.90.9-0.20.90.2-1.0-1.1
Short access total infusions1.51.73.61.6-1.9-1.9-1.6-1.8-1.41.9-0.70.70.70.4-0.2-0.6-0.6
Short access day 1 locomotion3.23.45.92.3-2.4-2.4-2.4-2.3-2.31.6-1.81.81.6-0.9-1.30.50.1
Short access day 10 total locomotion2.22.55.11.1-1.4-1.4-1.3-0.9-1.8-0.3-2.22.21.2-2.1-2.11.60.7
Short access total locomotion1.11.22.61.0-1.2-1.2-1.0-1.1-1.60.3-0.90.90.9-1.3-1.60.70.5
One hour access (0.3 mA shock)5.96.913.33.6-3.6-3.6-3.5-3.6-2.63.7-2.02.01.50.4-0.9-0.6-0.9
Compulsive drug intake0.30.30.6-0.10.70.70.40.40.80.00.7-0.7-0.40.80.7-0.0-0.0
One hour access (shock baseline)3.13.67.62.3-2.8-2.8-2.4-2.5-2.12.2-1.71.71.1-0.3-0.9-0.4-0.6
Social response proportion7.48.012.23.1-2.9-2.9-2.9-2.8-3.31.3-2.32.33.5-3.1-3.52.72.2
Social responses2.32.95.72.4-1.6-1.6-1.9-1.7-1.91.4-1.41.42.0-0.8-2.21.61.1
Social time2.73.67.62.2-1.7-1.7-1.7-1.8-1.81.0-0.70.72.6-2.2-2.82.32.3
Soleus weight1.74.910.32.6-1.7-1.7-2.7-1.8-2.00.4-3.23.22.3-1.9-2.32.50.8
Bone: stiffness0.10.11.00.00.20.20.20.31.0-0.10.2-0.2-0.00.20.00.40.3
Tibialis anterior weight0.30.93.7-0.1-0.1-0.1-0.30.00.10.5-0.80.8-1.31.51.1-1.4-1.9
Time to tail flick, vehicle, before self-admin0.70.81.61.3-0.9-0.9-1.2-0.8-0.90.1-1.21.20.7-0.3-0.51.00.1
Time to tail flick, vehicle, after self-admin0.20.20.80.00.30.30.10.20.1-0.7-0.00.00.7-0.5-0.30.90.7
Time to tail flick, test, before self-admin0.40.41.3-0.20.60.60.20.40.3-1.1-0.30.30.4-0.9-0.51.00.8
Time to tail flick, test, after self-admin0.10.10.10.40.20.2-0.4-0.2-0.30.1-0.40.40.20.40.3-0.0-0.3
Delta time to tail flick, vehicle, before/after SA0.30.31.2-0.50.60.60.70.30.4-0.11.1-1.10.20.00.1-0.10.6
Delta time to tail flick, test, before/after SA0.20.20.60.6-0.3-0.3-0.5-0.4-0.80.6-0.30.30.20.60.3-0.2-0.5
Tibia length0.92.412.50.10.40.40.41.31.0-2.0-1.01.01.3-1.6-1.53.52.3
Ambulatory time before self-admin0.90.93.4-1.20.90.91.01.21.0-1.80.5-0.50.1-1.20.30.90.9
Ambulatory time after self-admin2.93.29.51.0-0.8-0.8-0.9-0.5-0.9-1.0-1.71.72.4-3.1-2.13.02.4
Bone: tissue strength0.40.41.60.2-0.7-0.7-0.3-0.8-0.11.20.6-0.6-0.10.30.0-1.3-0.4
Total heroin consumption0.70.82.30.4-0.8-0.8-0.6-0.5-0.01.3-0.50.5-1.11.40.5-1.4-1.5
Bone: trabecular number1.72.66.31.9-2.1-2.1-2.1-2.2-1.62.5-1.41.41.00.0-0.8-0.6-0.5
Bone: trabecular spacing1.01.32.6-1.41.11.11.21.41.3-1.10.4-0.4-1.61.11.3-0.7-1.0
Bone: trabecular thickness4.14.912.42.6-2.6-2.6-2.9-2.0-2.21.6-3.53.51.0-0.2-0.90.6-1.0
Bone: trabecular tissue density0.30.41.8-0.70.80.80.40.70.0-1.4-0.40.4-0.4-0.50.30.3-0.2
Water consumed over 24 hours1.11.32.41.2-0.9-0.9-1.2-0.9-0.80.0-1.31.31.5-1.4-1.11.50.9
Number of responses in last shaping day0.20.20.60.4-0.1-0.1-0.1-0.2-0.3-0.00.1-0.10.8-0.4-0.50.60.7