Hub : Genes

Ppm1g

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain mRNA stability Ppm1g 0.04 0.04 2.0e-03 0.02 0.02 0.02 0.02 2.2e-03 3.1e-03 7.5e-03 3.4e-03
2 Adipose mRNA stability Ppm1g 0.03 0.04 1.3e-03 0.02 0.01 0.02 0.01 3.0e-03 2.1e-02 4.8e-03 1.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density3.86.59.0-3.0-2.0
Area under the delay curve0.10.10.2-0.2-0.5
BMI with tail0.20.70.80.90.8
BMI without tail0.61.81.91.41.3
Body weight1.88.19.33.02.6
Weight adjusted by age0.00.00.0-0.10.1
Bone surface2.13.75.9-2.4-1.3
Bone volume2.03.55.8-2.4-1.1
Breakpoint value in progressive ratio session0.50.60.8-0.9-0.6
Number of licking bursts0.00.00.1-0.3-0.1
Context. condit. distance diff. score0.00.00.0-0.1-0.1
Locomotion velocity, session 10.10.10.3-0.10.5
Locomotion distance, session 12.12.62.8-1.7-1.6
Locomotion velocity, session 20.10.10.30.5-0.0
Locomotion distance, session 20.00.10.1-0.1-0.3
Locomotion velocity, session 30.40.40.7-0.9-0.4
Locomotion distance, session 30.91.01.0-1.0-1.0
Stereotopy head waving bouts, day 31.61.82.2-1.5-1.2
Stereotopy head waving duration, day 30.00.00.1-0.3-0.1
Locomotion velocity, session 70.70.81.5-1.20.0
Locomotion distance, session 70.40.50.9-0.40.9
Stereotopy head waving bouts, day 70.30.30.6-0.1-0.8
Stereotopy head waving duration, day 70.91.12.0-0.5-1.4
Locomotion velocity, session 80.10.10.2-0.50.1
Locomotion distance, session 80.40.50.6-0.8-0.7
Degree of sensitization distance1.81.93.00.91.7
Degree of sensitization stereotypy0.20.30.30.5-0.5
Conditioned locomotion3.33.84.2-1.9-2.0
Cocaine response after cond. corrected0.81.01.3-0.8-1.2
Cocaine response after cond. not corrected1.72.02.2-1.3-1.5
Cocaine response before conditioning1.11.31.9-1.4-0.8
Saline control response0.60.80.9-1.0-0.8
Bone: connectivity density3.85.97.7-2.8-2.0
Bone: cortical apparent density0.60.80.8-0.8-0.9
Bone: cortical area0.50.71.5-1.20.0
Bone: cortical porosity1.41.51.8-1.1-1.3
Bone: cortical porosity1.21.41.4-1.2-1.2
Bone: cortical thickness0.00.10.1-0.20.3
Bone: cortical thickness1.21.52.0-1.4-1.0
Bone: cortical tissue density0.40.50.6-0.7-0.8
Condit. Reinf. active minus inactive responses0.91.01.20.81.1
Condit. Reinf. active-inactive response ratio1.01.01.20.91.1
Condit. Reinf. active responses0.10.10.2-0.4-0.2
Condit. Reinf. inactive responses1.62.02.1-1.5-1.4
Incentive salience index mean0.10.10.1-0.10.4
Condit. Reinf. lever presses0.50.71.0-1.0-0.7
Condit. Reinf. active minus inactive responses3.84.95.4-2.1-2.3
Condit. Reinf. active-inactive response ratio1.41.62.3-1.0-1.5
Condit. Reinf. active responses2.33.24.0-2.0-1.5
Condit. Reinf. inactive responses0.71.01.9-1.4-0.3
Condit. Reinf. lever presses1.92.72.7-1.6-1.6
Condit. Reinf. lever reinforcers received2.12.93.6-1.9-1.5
Conditioned reinforcement - actives0.91.52.0-1.4-1.0
Conditioned reinforcement - inactives2.74.04.4-2.1-1.9
Conditioned locomotion0.70.91.6-0.31.3
Patch foraging indifference point 0 sec0.91.83.00.71.7
Patch foraging indifference point AUC1.62.32.8-1.7-1.3
Delay disc. indifference point, 0s delay2.12.33.61.91.0
Delay disc. indifference point, 16s delay0.10.10.1-0.2-0.4
Delay disc. indifference point, 2s delay0.20.20.20.40.5
Delay disc. indifference point, 24s delay1.92.13.5-0.8-1.9
Delay disc. indifference point, 4s delay0.00.00.1-0.1-0.3
Delay disc. indifference point, 8s delay0.10.10.1-0.0-0.4
Indifference point function ln k0.00.00.0-0.00.0
Indifference point function log k0.00.00.0-0.00.0
Patch foraging total patch changes 0 sec0.81.62.70.71.6
Patch foraging total patch changes 12 sec1.41.82.51.11.6
Patch foraging total patch changes 18 sec0.20.40.70.10.8
Patch foraging total patch changes 24 sec1.11.92.71.01.6
Patch foraging total patch changes 6 sec0.10.20.30.30.6
Patch foraging time to switch 0 sec0.00.10.20.40.2
Patch foraging water rate 0 sec0.00.10.1-0.3-0.1
Patch foraging water rate 12 sec0.71.51.91.41.0
Patch foraging water rate 18 sec0.50.81.01.00.7
Patch foraging water rate 24 sec2.02.83.21.81.6
Patch foraging water rate 6 sec0.81.21.61.20.9
Seeking ratio, delayed vs. immediate footshock0.10.10.20.20.5
Distance traveled before self-admin0.10.10.2-0.1-0.4
Distance traveled after self-admin1.21.51.61.31.1
Extensor digitorum longus weight4.015.617.9-4.2-3.6
Bone: elastic displacement1.01.11.8-0.7-1.3
Bone: elastic work0.91.21.2-1.1-1.1
Bone: endosteal estimation0.40.91.7-1.3-0.2
Bone: endosteal perimeter0.20.30.6-0.8-0.0
Epididymis fat weight16.556.661.27.87.2
Delta time in closed arm before/after self-admin0.00.00.0-0.2-0.1
Delta time in open arm before/after self-admin0.00.00.1-0.20.1
Diff in mean of infusions in LGA sessions0.10.10.1-0.20.3
Delay discount exponential model param0.30.40.50.50.7
Extinction: sum of active levers before priming0.30.40.4-0.6-0.6
Active lever presses in extinction session 60.30.30.5-0.70.2
Bone: final force0.30.40.6-0.50.8
Bone: final moment0.30.50.6-0.60.8
Food consumed during 24 hour testing period0.20.20.4-0.6-0.3
Glucose0.30.50.60.50.8
Heart weight2.94.55.31.92.3
Delay discount hyperbolic model param0.10.10.10.40.4
Intermittent access intake day 1-15 change0.10.30.3-0.40.6
Intermittent access intake escalation0.10.30.6-0.10.7
Intermittent access intake escalation 20.50.61.1-0.21.1
Intermitt. access day 1 inactive lever presses0.31.21.5-1.2-0.9
Intermitt. access day 15 inactive lever presses3.77.59.7-3.1-2.3
Intermitt. access escalation Index0.40.61.10.31.1
Intermittent access day 1 total infusions2.84.55.0-2.2-2.0
Intermittent access day 15 total infusions1.11.72.7-1.6-0.8
Intermittent access terminal intake (last 3 days)1.72.33.6-1.9-1.0
Intermittent access total infusions1.82.22.3-1.5-1.4
Intermittent access day 1 locomotion1.31.62.0-1.4-1.1
Intermittent access day 15 total locomotion0.10.10.2-0.5-0.1
Intermittent access total locomotion0.10.10.1-0.4-0.2
Intermittent access standard deviation0.51.01.4-1.2-0.7
Left kidney weight0.00.00.10.3-0.0
Right kidney weight0.31.52.41.50.8
Cocaine induced anxiety0.10.20.4-0.60.1
Post-drug Anxiety0.90.91.21.10.8
Baseline Anxiety2.32.74.42.11.0
Tail length0.41.71.91.41.3
Length with tail1.88.08.83.02.7
Length without tail0.62.02.01.41.4
Times rat made contact with spout1.92.12.4-1.6-1.4
Lifetime Intake1.82.22.7-1.6-1.3
Liver weight, left3.86.36.52.62.5
Liver weight, right10.017.517.54.24.2
Locomotor activity0.30.40.60.80.5
Locomotor testing distance0.10.10.2-0.3-0.4
Locomotor testing rearing0.20.30.5-0.7-0.4
Locomotion in novel chamber1.01.32.40.41.6
Locomotion in novel chamber post-restriction2.94.75.82.41.9
Fecal boli incidents, locomotor time 10.60.81.3-0.6-1.1
Change in fecal boli incidents, locomotor task3.73.64.42.11.7
Time >=10cm from walls, locomotor time 10.20.20.30.3-0.6
Bouts of movement, locomotor time 12.02.32.3-1.5-1.5
Total resting periods, locomotor time 12.32.62.7-1.6-1.6
Rest time, locomotor task time 10.10.10.20.20.5
Distance moved, locomotor task time 10.81.21.31.11.1
Vertical activity count, locomotor time 10.10.30.50.70.2
Time >=10cm from walls, locomotor time 20.10.10.2-0.40.2
Bouts of movement, locomotor time 20.10.10.10.2-0.4
Total resting periods, locomotor time 20.10.20.4-0.2-0.7
Rest time, locomotor task time 21.31.61.7-1.3-1.2
Distance moved, locomotor task time 22.12.53.71.11.9
Vertical activity count, locomotor time 20.60.81.00.81.0
Light reinforcement 12.45.88.5-2.9-1.8
Light reinforcement 22.94.55.7-2.4-1.8
Bone: marrow area0.40.91.7-1.3-0.2
Bone: maximum diameter0.81.52.7-1.6-0.5
Bone: maximum force0.20.40.4-0.60.6
Bone: maximum moment0.30.50.6-0.80.6
Mean time between licks in bursts1.23.03.71.91.5
Mean num. licks in bursts0.10.20.2-0.4-0.4
Cd content in liver0.00.00.0-0.1-0.2
Co content in liver5.76.67.7-2.8-2.3
Cu content in liver0.10.10.1-0.3-0.2
Fe content in liver0.50.61.0-1.0-0.4
K content in liver0.50.50.8-0.9-0.4
Mg content in liver0.40.40.8-0.9-0.3
Mn content in liver0.10.10.1-0.30.1
Na content in liver0.40.40.7-0.8-0.4
Rb content in liver0.00.00.0-0.1-0.0
Se content in liver0.40.50.80.30.9
Sr content in liver0.20.10.10.40.3
Zn content in liver0.91.01.30.81.1
Bone: minimum diameter0.50.91.80.11.3
Time in familiar zone, hab. session 10.90.81.10.71.1
Time in novel zone, hab. session 10.70.70.80.90.7
Total zone transitions, hab. session 10.10.10.2-0.4-0.3
Total locomotion distance, hab. session 10.10.20.3-0.5-0.2
Locomotion velocity, hab. session 10.91.31.6-1.3-1.0
Time in familiar zone, hab. session 20.10.10.2-0.20.4
Time in novel zone, hab. session 20.40.40.70.80.4
Total zone transitions, hab. session 20.20.20.3-0.4-0.5
Total locomotion distance, hab. session 20.40.50.8-0.5-0.9
Locomotion velocity, hab. session 20.70.91.3-0.7-1.2
Novel to familiar place preference ratio0.60.61.21.10.2
Novelty place preference1.01.11.91.40.5
Time in novel zone, NPP test1.21.32.21.50.7
Total zone transitions, NPP test1.72.52.5-1.5-1.6
Total locomotion distance, NPP test2.43.33.7-1.7-1.9
Locomotion velocity, NPP test4.05.76.5-2.2-2.5
Intraocular pressure4.97.18.83.02.3
Delta distance traveled before/after self-admin2.12.33.11.21.8
Delta ambulatory time before/after self-admin0.50.61.20.31.1
Parametrial fat weight10.324.225.34.85.0
Pavlov. Cond. lever latency1.51.82.51.61.1
Pavlov. Cond. magazine entry latency0.10.20.2-0.4-0.4
Pavlov. Cond. change in total contacts0.00.00.1-0.2-0.1
Pavlov. Cond. index score0.70.91.2-1.1-0.8
Pavlov. Cond. latency score0.70.81.2-1.1-0.7
Pavlov. Cond. lever contacts1.01.21.6-1.3-0.9
Pavlov. Cond. magazine entry number0.50.60.80.90.6
Pavlov. Cond. intertrial magazine entries0.70.81.3-1.1-0.6
Pavlov. Cond. lever-magazine prob. diff.1.51.92.1-1.4-1.3
Pavlov. Cond. response bias1.41.82.0-1.4-1.3
Pavlov. Cond. lever latency1.42.02.11.41.4
Pavlov. Cond. magazine entry latency0.20.20.4-0.60.0
Pavlov. Cond. change in total contacts1.01.62.4-0.9-1.5
Pavlov. Cond. index score1.01.31.5-1.2-1.1
Pavlov. Cond. latency score1.11.41.6-1.2-1.1
Pavlov. Cond. lever contacts1.01.41.7-1.1-1.3
Pavlov. Cond. magazine entry number0.10.10.20.50.0
Pavlov. Cond. intertrial magazine entries3.65.45.92.42.2
Pavlov. Cond. lever-magazine prob. diff.0.60.91.0-1.0-0.8
Pavlov. Cond. response bias1.52.02.2-1.5-1.4
Time in closed arm before self-admin1.62.02.61.21.6
Time in closed arm after self-admin2.32.43.01.41.7
Time in open arm before self-admin0.70.71.3-0.4-1.1
Time in open arm after self-admin1.41.51.8-1.4-1.1
Bone: periosteal estimation0.71.52.9-1.7-0.3
Bone: periosteal perimeter0.30.51.0-1.0-0.1
Bone: post-yield work0.50.71.2-1.1-0.4
Progressive ratio test 1 active lever presses0.91.11.4-1.2-0.9
Progressive ratio test 1 breakpoint1.01.21.4-1.2-1.0
Progressive ratio test 1 inactive lever presses3.14.44.7-2.0-2.2
Progressive ratio test 2 active lever presses0.10.20.3-0.50.2
Progressive ratio test 2 breakpoint0.10.10.2-0.50.2
Progressive ratio test 2 inactive lever presses0.71.22.2-1.5-0.5
Incentive Sensitization - Responses0.20.20.3-0.50.4
Incentive Sensitization - Breakpoint0.20.30.4-0.40.6
Sum of active levers in priming session hrs 5-60.60.60.6-0.8-0.7
Progressive ratio0.10.10.20.10.5
Food seeking constrained by brief footshock3.34.04.1-2.0-2.0
Seeking ratio, punishment vs. effort0.81.21.9-0.7-1.4
Retroperitoneal fat weight22.093.794.39.79.7
Reaction time number correct0.61.21.3-1.1-1.1
Reaction time mean minus median0.00.00.00.1-0.0
Reaction time mean minus median AUC0.00.00.10.3-0.0
Reaction time num false alarms0.00.00.1-0.0-0.3
Reaction time num false alarms AUC0.00.00.1-0.0-0.3
Reaction time trials correct on left0.61.21.3-1.1-1.1
Reaction time trials on left0.71.31.4-1.1-1.2
Reaction time mean1.21.82.01.31.4
Reaction time mean AUC1.01.51.71.21.3
Median of all reaction times1.52.22.51.31.6
Reaction time omissions0.00.10.1-0.3-0.2
Reaction time false alarm rate0.10.20.20.50.4
Reaction time premature initiation rate0.10.20.30.5-0.3
Reaction time premature initiations0.30.51.0-0.1-1.0
Std. dev. reaction times0.30.60.80.60.9
Reaction time trials completed0.71.31.4-1.1-1.2
Reaction time trials AUC0.81.51.5-1.2-1.2
Run reversals in cocaine runway, females0.50.50.90.3-0.9
Run reversals in cocaine runway, males1.31.32.7-0.0-1.6
Latency to leave start box in cocaine runway0.20.30.4-0.7-0.3
Latency to leave start box in cocaine runway, F0.10.10.1-0.4-0.3
Latency to leave start box in cocaine runway, M0.00.00.0-0.20.0
Std. dev. time between licks in bursts0.10.20.30.20.5
Total sessions with >9 infusions0.40.50.8-0.9-0.4
Short access day 1 total inactive lever presses8.411.011.9-3.2-3.4
Short access day 10 total inactive lever presses2.15.05.9-2.0-2.4
Short access day 1 total infusions2.73.64.9-2.2-1.5
Short access day 10 total infusions2.12.62.8-1.6-1.7
Short access total infusions0.70.81.3-1.1-0.6
Short access day 1 locomotion2.02.53.2-1.8-1.3
Short access day 10 total locomotion0.91.61.8-1.3-1.2
Short access total locomotion0.00.00.1-0.30.0
One hour access (0.3 mA shock)0.80.91.7-1.3-0.4
Compulsive drug intake0.60.70.80.9-0.7
One hour access (shock baseline)1.01.52.8-1.7-0.4
Social response proportion0.91.01.70.51.3
Social responses0.30.40.70.20.8
Social time0.81.01.70.71.3
Soleus weight4.814.114.5-3.7-3.8
Bone: stiffness0.10.20.4-0.20.7
Tibialis anterior weight3.110.613.4-3.7-2.8
Time to tail flick, vehicle, before self-admin1.01.11.51.20.8
Time to tail flick, vehicle, after self-admin3.64.85.82.41.9
Time to tail flick, test, before self-admin0.20.20.3-0.1-0.6
Time to tail flick, test, after self-admin0.10.10.2-0.10.4
Delta time to tail flick, vehicle, before/after SA0.40.40.70.30.8
Delta time to tail flick, test, before/after SA1.01.01.7-1.3-0.6
Tibia length3.39.011.32.63.4
Ambulatory time before self-admin0.10.20.4-0.2-0.6
Ambulatory time after self-admin0.70.90.90.91.0
Bone: tissue strength1.01.01.01.01.0
Total heroin consumption2.42.83.9-2.0-1.3
Bone: trabecular number3.25.36.6-2.6-2.0
Bone: trabecular spacing2.43.14.72.21.2
Bone: trabecular thickness0.50.61.3-1.10.1
Bone: trabecular tissue density0.30.40.6-0.8-0.5
Water consumed over 24 hours0.40.61.0-1.0-0.3
Number of responses in last shaping day0.10.10.2-0.4-0.2