Hub : Genes

Slc30a3

solute carrier family 30 member 3

chr6:30984241–31004689 (+)

Slc30a3 RatGTEx page

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	IL	gene expression	Slc30a3	0.24	0.16	2.9e-04	0.11	0.11	0.11	0.1	1.5e-03	1.5e-03	1.1e-03	2.1e-03
2	BLA	gene expression	Slc30a3	0.1	0.07	1.7e-05	0.1	0.09	0.1	0.1	7.3e-06	1.3e-05	7.5e-06	7.5e-06
3	Liver	mRNA stability	Slc30a3	0.04	0.04	1.9e-04	0.02	0.02	0.02	0.02	9.0e-04	2.1e-03	1.3e-03	1.9e-03
4	PL	gene expression	Slc30a3	0.07	0.05	1.3e-10	0.09	0.1	0.09	0.09	1.8e-10	5.8e-11	2.7e-10	2.8e-10
5	Liver	gene expression	Slc30a3	0.81	0.14	0.0e+00	0.22	0.22	0.22	0.22	1.9e-24	9.9e-24	1.7e-24	5.4e-24
6	IC	gene expression	Slc30a3	0.14	0.08	3.3e-07	0.12	0.15	0.11	0.14	7.0e-06	8.7e-07	2.9e-05	2.6e-06
7	Brain	gene expression	Slc30a3	0.08	0.05	8.4e-10	0.08	0.09	0.08	0.08	7.5e-08	1.3e-08	3.4e-08	4.7e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bone: apparent density	4.3	7.3	9.8	2.3	3.1	-1.9	2.9	-2.9	2.8	2.8
Area under the delay curve	0.1	0.1	0.4	0.1	0.7	-0.3	0.3	-0.4	0.3	0.3
BMI with tail	0.7	2.4	7.5	-2.1	-0.9	2.7	-1.1	1.0	-1.0	-1.0
BMI without tail	1.0	3.0	6.4	-2.1	-1.5	2.5	-1.5	1.4	-1.4	-1.4
Body weight	2.5	10.8	13.1	-3.6	-3.1	3.5	-3.2	3.2	-3.1	-3.1
Weight adjusted by age	0.1	0.1	0.2	0.5	0.1	-0.1	0.3	-0.4	0.3	0.3
Bone surface	2.1	3.9	5.8	1.4	2.4	-0.8	2.2	-2.3	2.1	2.0
Bone volume	2.2	4.0	5.8	1.5	2.4	-1.1	2.2	-2.2	2.1	2.1
Breakpoint value in progressive ratio session	0.7	0.8	1.2	0.7	1.1	-0.3	0.9	-1.1	1.0	1.0
Number of licking bursts	0.2	0.4	1.5	-1.0	0.5	1.2	0.1	-0.2	0.1	0.1
Context. condit. distance diff. score	0.0	0.0	0.2	0.2	-0.1	-0.4	0.0	0.0	0.0	0.0
Locomotion velocity, session 1	0.1	0.1	0.4	-0.6	-0.2	0.3	-0.1	0.2	-0.1	-0.2
Locomotion distance, session 1	1.5	1.8	2.3	1.0	1.5	-1.1	1.5	-1.5	1.4	1.4
Locomotion velocity, session 2	0.2	0.3	0.3	-0.5	-0.5	0.5	-0.5	0.6	-0.6	-0.5
Locomotion distance, session 2	0.0	0.0	0.0	0.1	-0.0	0.1	0.1	-0.0	0.0	0.0
Locomotion velocity, session 3	0.7	0.7	1.1	1.0	0.6	-0.6	0.9	-0.9	1.0	1.0
Locomotion distance, session 3	0.6	0.7	0.9	0.7	0.9	-0.2	0.9	-0.9	0.9	0.9
Stereotopy head waving bouts, day 3	1.9	2.2	2.9	1.7	1.3	-1.1	1.5	-1.5	1.6	1.6
Stereotopy head waving duration, day 3	0.1	0.2	0.3	0.5	0.2	-0.3	0.4	-0.4	0.5	0.5
Locomotion velocity, session 7	0.9	1.0	1.5	0.6	1.1	0.2	1.1	-1.2	1.2	1.1
Locomotion distance, session 7	0.2	0.3	1.1	-0.7	0.0	1.1	0.2	-0.3	0.2	0.2
Stereotopy head waving bouts, day 7	0.0	0.0	0.1	0.2	0.2	0.3	0.1	-0.0	0.1	0.1
Stereotopy head waving duration, day 7	0.4	0.5	1.3	1.1	0.6	-0.7	0.6	-0.5	0.6	0.7
Locomotion velocity, session 8	0.3	0.3	0.7	0.9	0.2	-0.6	0.5	-0.6	0.5	0.4
Locomotion distance, session 8	0.3	0.4	0.5	0.6	0.5	-0.7	0.7	-0.6	0.6	0.6
Degree of sensitization distance	1.2	1.2	2.2	-1.5	-1.0	1.4	-0.9	0.9	-0.9	-1.0
Degree of sensitization stereotypy	0.2	0.2	0.4	-0.3	-0.3	0.6	-0.5	0.6	-0.5	-0.4
Conditioned locomotion	3.4	3.9	5.0	2.2	1.8	-2.2	1.9	-1.9	1.9	1.9
Cocaine response after cond. corrected	0.5	0.6	0.8	0.2	0.9	-0.4	0.9	-0.9	0.9	0.8
Cocaine response after cond. not corrected	1.4	1.6	2.4	0.9	1.6	-1.0	1.4	-1.4	1.3	1.3
Cocaine response before conditioning	2.0	2.4	3.9	2.0	1.5	-2.0	1.3	-1.3	1.3	1.3
Saline control response	0.7	0.9	1.5	1.2	0.9	-1.0	1.0	-0.9	0.9	0.9
Bone: connectivity density	3.9	6.2	8.3	2.1	2.9	-1.4	2.7	-2.7	2.7	2.6
Bone: cortical apparent density	0.4	0.5	1.1	0.2	1.1	-0.3	0.8	-0.8	0.8	0.8
Bone: cortical area	0.5	0.7	1.1	0.2	1.0	0.1	1.0	-1.0	0.9	0.9
Bone: cortical porosity	1.8	1.9	3.6	1.9	1.2	-1.9	1.2	-1.1	1.1	1.1
Bone: cortical porosity	1.7	1.9	3.0	1.7	1.2	-1.7	1.2	-1.2	1.2	1.2
Bone: cortical thickness	0.0	0.1	0.3	-0.5	0.1	0.6	0.0	0.0	-0.1	-0.1
Bone: cortical thickness	1.2	1.4	1.8	0.9	1.3	-0.6	1.3	-1.3	1.3	1.3
Bone: cortical tissue density	0.3	0.4	0.8	0.0	0.9	-0.2	0.6	-0.7	0.6	0.6
Condit. Reinf. active minus inactive responses	1.0	1.1	2.3	-1.5	-0.7	1.5	-0.9	0.8	-0.8	-0.9
Condit. Reinf. active-inactive response ratio	1.0	1.0	1.9	-1.3	-0.7	1.4	-1.0	0.9	-0.9	-0.9
Condit. Reinf. active responses	0.1	0.1	0.4	-0.2	0.6	0.1	0.3	-0.3	0.4	0.4
Condit. Reinf. inactive responses	1.5	1.9	2.4	1.2	1.5	-1.3	1.4	-1.3	1.4	1.4
Incentive salience index mean	0.1	0.1	0.4	-0.6	0.3	0.6	0.1	-0.1	0.1	0.1
Condit. Reinf. lever presses	0.6	0.9	1.5	0.6	1.2	-0.7	1.0	-1.0	0.9	0.9
Condit. Reinf. active minus inactive responses	3.8	4.9	6.4	2.5	2.0	-2.2	2.2	-2.1	2.2	2.3
Condit. Reinf. active-inactive response ratio	1.1	1.2	1.9	1.4	0.9	-1.4	1.0	-0.9	1.0	1.1
Condit. Reinf. active responses	3.2	4.4	5.4	2.3	2.1	-1.9	2.1	-2.0	2.1	2.2
Condit. Reinf. inactive responses	1.4	1.8	2.3	1.2	1.5	-0.7	1.4	-1.5	1.5	1.4
Condit. Reinf. lever presses	2.2	3.0	3.7	1.9	1.6	-1.9	1.7	-1.7	1.6	1.7
Condit. Reinf. lever reinforcers received	2.9	4.0	5.0	2.2	2.0	-1.8	2.0	-2.0	2.0	2.0
Conditioned reinforcement - actives	1.8	3.1	7.8	2.4	1.0	-2.8	1.4	-1.5	1.3	1.3
Conditioned reinforcement - inactives	2.7	4.0	5.4	1.5	2.3	-1.8	2.1	-2.1	2.1	2.0
Conditioned locomotion	0.5	0.7	2.2	1.3	-0.3	-1.5	0.3	-0.5	0.3	0.3
Patch foraging indifference point 0 sec	0.4	0.8	1.3	-1.0	-0.5	1.1	-0.9	0.9	-0.8	-0.8
Patch foraging indifference point AUC	0.9	1.4	2.0	0.2	1.4	-0.0	1.4	-1.4	1.4	1.3
Delay disc. indifference point, 0s delay	2.6	2.9	3.4	-1.8	-1.4	1.3	-1.8	1.7	-1.8	-1.8
Delay disc. indifference point, 16s delay	0.1	0.2	0.4	0.3	0.6	-0.6	0.3	-0.3	0.3	0.3
Delay disc. indifference point, 2s delay	0.1	0.2	0.3	-0.6	-0.3	0.2	-0.4	0.4	-0.4	-0.4
Delay disc. indifference point, 24s delay	1.4	1.6	3.1	1.1	1.5	-1.8	1.0	-1.1	1.0	1.1
Delay disc. indifference point, 4s delay	0.0	0.0	0.1	-0.3	0.2	0.2	0.1	-0.2	0.1	0.1
Delay disc. indifference point, 8s delay	0.1	0.1	0.2	0.2	0.5	-0.3	0.2	-0.3	0.2	0.2
Indifference point function ln k	0.2	0.3	1.2	1.0	0.0	-1.1	0.1	-0.1	0.1	0.1
Indifference point function log k	0.2	0.3	1.2	1.0	0.0	-1.1	0.1	-0.1	0.1	0.1
Patch foraging total patch changes 0 sec	0.4	0.8	1.6	-1.1	-0.4	1.2	-0.8	0.8	-0.8	-0.8
Patch foraging total patch changes 12 sec	1.3	1.7	2.7	-1.7	-0.9	1.6	-1.2	1.2	-1.1	-1.1
Patch foraging total patch changes 18 sec	0.3	0.4	1.8	-0.9	-0.1	1.3	-0.3	0.3	-0.3	-0.3
Patch foraging total patch changes 24 sec	0.8	1.3	1.6	-1.3	-1.1	1.2	-1.1	1.1	-1.1	-1.1
Patch foraging total patch changes 6 sec	0.4	0.6	2.0	-1.1	-0.0	1.4	-0.4	0.4	-0.3	-0.4
Patch foraging time to switch 0 sec	0.1	0.1	0.7	-0.4	-0.3	0.8	-0.2	0.2	-0.1	-0.1
Patch foraging water rate 0 sec	0.1	0.3	1.2	0.9	0.2	-1.1	0.2	-0.2	0.1	0.1
Patch foraging water rate 12 sec	0.7	1.6	2.5	-0.4	-1.6	0.1	-1.4	1.4	-1.5	-1.4
Patch foraging water rate 18 sec	0.5	0.8	1.1	0.5	-1.0	-1.0	-0.9	0.9	-0.9	-0.9
Patch foraging water rate 24 sec	1.8	2.5	3.9	-0.8	-2.0	1.0	-1.8	1.7	-1.8	-1.7
Patch foraging water rate 6 sec	0.9	1.3	1.9	-0.2	-1.4	-0.3	-1.3	1.3	-1.4	-1.3
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.2	0.0	-0.5	-0.0	-0.2	0.2	-0.2	-0.2
Distance traveled before self-admin	0.1	0.1	0.6	0.4	-0.4	-0.8	-0.0	0.1	-0.2	-0.1
Distance traveled after self-admin	2.0	2.4	3.8	-1.4	-1.9	1.1	-1.5	1.6	-1.6	-1.6
Extensor digitorum longus weight	4.3	17.0	18.7	4.1	4.3	-3.4	4.3	-4.2	4.2	4.2
Bone: elastic displacement	0.9	1.0	2.5	1.1	0.8	-1.6	0.8	-0.8	0.8	0.9
Bone: elastic work	1.0	1.2	1.7	1.0	1.1	-1.3	1.1	-1.1	1.1	1.1
Bone: endosteal estimation	0.5	1.2	1.8	0.7	1.2	-0.2	1.2	-1.3	1.2	1.2
Bone: endosteal perimeter	0.2	0.5	0.8	0.3	0.8	-0.2	0.8	-0.9	0.8	0.7
Epididymis fat weight	16.8	57.6	59.9	-7.7	-7.6	7.5	-7.7	7.5	-7.5	-7.6
Delta time in closed arm before/after self-admin	0.2	0.2	0.9	-0.5	-0.1	1.0	0.1	-0.1	0.1	0.1
Delta time in open arm before/after self-admin	0.1	0.1	0.1	0.2	0.3	-0.2	0.3	-0.3	0.4	0.4
Diff in mean of infusions in LGA sessions	0.0	0.0	0.1	-0.1	0.4	0.3	0.1	-0.2	0.1	0.1
Delay discount exponential model param	0.4	0.4	0.8	-0.4	-0.9	0.6	-0.6	0.7	-0.6	-0.7
Extinction: sum of active levers before priming	0.3	0.3	0.6	-0.0	0.8	0.3	0.5	-0.6	0.6	0.6
Active lever presses in extinction session 6	0.6	0.6	1.2	1.1	0.5	-0.8	0.7	-0.8	0.8	0.8
Bone: final force	0.1	0.1	0.2	-0.2	0.2	0.1	0.4	-0.5	0.4	0.3
Bone: final moment	0.1	0.1	0.3	-0.1	0.3	0.0	0.5	-0.5	0.5	0.4
Food consumed during 24 hour testing period	0.1	0.2	0.2	0.2	0.5	0.0	0.5	-0.4	0.5	0.4
Glucose	0.3	0.5	1.1	-0.9	-0.6	1.0	-0.6	0.5	-0.6	-0.6
Heart weight	3.0	4.7	5.1	-2.3	-2.2	2.0	-2.1	2.2	-2.2	-2.2
Delay discount hyperbolic model param	0.2	0.2	0.5	-0.1	-0.7	0.3	-0.5	0.5	-0.5	-0.5
Intermittent access intake day 1-15 change	0.1	0.2	0.9	0.9	-0.2	-0.8	0.3	-0.2	0.2	0.2
Intermittent access intake escalation	0.0	0.1	0.3	0.5	-0.4	-0.5	0.0	0.1	-0.1	-0.1
Intermittent access intake escalation 2	0.0	0.0	0.1	0.3	-0.3	0.0	0.1	0.1	-0.1	-0.1
Intermitt. access day 1 inactive lever presses	0.4	1.5	1.7	1.2	1.1	-1.3	1.3	-1.2	1.3	1.2
Intermitt. access day 15 inactive lever presses	3.0	6.1	7.9	1.8	2.5	-1.7	2.8	-2.7	2.8	2.7
Intermitt. access escalation Index	1.3	1.9	8.0	-1.6	-0.9	2.8	-0.6	0.7	-0.6	-0.6
Intermittent access day 1 total infusions	3.4	5.5	6.4	2.4	2.4	-2.5	2.3	-2.3	2.3	2.3
Intermittent access day 15 total infusions	1.7	2.5	3.7	1.9	1.4	-1.9	1.5	-1.4	1.4	1.4
Intermittent access terminal intake (last 3 days)	2.7	3.6	5.6	2.3	1.6	-2.4	1.8	-1.7	1.7	1.7
Intermittent access total infusions	2.9	3.5	6.3	2.3	1.6	-2.5	1.6	-1.6	1.6	1.6
Intermittent access day 1 locomotion	1.9	2.4	3.1	1.5	1.5	-1.8	1.5	-1.5	1.5	1.5
Intermittent access day 15 total locomotion	0.2	0.3	0.4	0.5	0.6	-0.6	0.5	-0.7	0.5	0.5
Intermittent access total locomotion	0.4	0.5	1.0	0.8	0.7	-1.0	0.5	-0.7	0.6	0.5
Intermittent access standard deviation	0.9	1.8	3.1	1.3	1.2	-1.8	1.3	-1.3	1.3	1.2
Left kidney weight	0.0	0.0	0.1	0.0	-0.4	-0.2	-0.2	0.2	-0.2	-0.2
Right kidney weight	0.4	1.8	2.3	-1.4	-1.1	0.9	-1.5	1.5	-1.4	-1.4
Cocaine induced anxiety	0.2	0.3	0.5	-0.1	0.7	0.4	0.5	-0.6	0.6	0.5
Post-drug Anxiety	1.4	1.5	2.4	-1.6	-0.8	1.4	-1.2	1.1	-1.1	-1.2
Baseline Anxiety	2.9	3.3	4.0	-1.7	-1.9	1.3	-2.0	1.9	-2.0	-2.0
Tail length	0.4	1.4	2.2	-0.8	-1.5	0.3	-1.3	1.3	-1.4	-1.3
Length with tail	1.6	6.9	9.6	-2.0	-3.1	1.3	-2.9	2.9	-2.9	-2.9
Length without tail	0.6	1.8	2.5	-1.1	-1.6	0.8	-1.4	1.4	-1.4	-1.4
LgA early post infusion interval	1.2	1.6	2.6	-1.3	-1.6	1.1	-1.2	1.2	-1.2	-1.2
LgA late post infusion interval	0.7	0.9	1.4	1.2	0.2	-1.2	0.8	-1.0	0.9	0.9
LgA early loading	2.5	4.7	5.5	2.0	2.3	-1.6	2.3	-2.3	2.3	2.3
LgA late loading	0.5	1.2	1.8	1.0	1.4	-0.9	1.1	-1.2	1.1	1.1
LgA early average infusions	2.4	3.0	3.8	1.6	1.9	-1.3	1.8	-1.8	1.8	1.7
LgA late average infusions	1.1	1.5	2.1	-1.1	-0.7	1.1	-1.4	1.3	-1.4	-1.4
LgA early timeout	3.5	3.7	4.2	2.0	1.9	-1.7	2.0	-2.0	1.9	1.9
LgA late timeout	0.5	0.7	1.7	-1.2	-0.3	1.3	-0.7	0.6	-0.7	-0.6
LgA early titration	1.2	1.6	2.1	1.2	1.5	-0.8	1.4	-1.4	1.3	1.3
LgA late titration	1.2	1.9	2.2	-1.3	-1.0	1.5	-1.4	1.4	-1.5	-1.5
LgA total infusion	0.2	0.3	0.5	-0.4	-0.1	0.5	-0.6	0.5	-0.7	-0.7
Times rat made contact with spout	1.6	1.9	2.4	1.1	1.5	-0.7	1.5	-1.5	1.5	1.5
Lifetime Intake	3.0	3.6	5.8	2.3	1.7	-2.4	1.7	-1.8	1.7	1.7
Liver weight, left	3.6	6.0	6.5	-2.4	-2.4	2.2	-2.6	2.6	-2.5	-2.5
Liver weight, right	9.3	16.3	18.5	-3.8	-4.2	3.2	-4.2	4.3	-4.2	-4.2
Locomotor activity	0.5	0.8	2.0	-1.4	-0.3	1.3	-0.7	0.6	-0.6	-0.6
Locomotor testing distance	0.2	0.3	0.8	-0.4	0.4	0.9	0.4	-0.4	0.5	0.5
Locomotor testing rearing	0.4	0.7	1.1	0.8	0.6	-0.3	0.9	-1.0	1.1	1.1
Locomotion in novel chamber	0.2	0.3	1.1	0.1	-1.0	0.1	-0.5	0.5	-0.4	-0.4
Locomotion in novel chamber post-restriction	3.0	4.9	5.2	-2.2	-2.3	2.2	-2.3	2.2	-2.2	-2.1
Fecal boli incidents, locomotor time 1	0.4	0.5	1.4	1.2	0.4	-1.1	0.6	-0.4	0.5	0.5
Change in fecal boli incidents, locomotor task	4.3	4.3	5.1	-2.2	-2.0	1.9	-2.1	2.0	-2.1	-2.1
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.2	0.1	-0.2	-0.5	-0.3	0.3	-0.3	-0.2
Bouts of movement, locomotor time 1	1.5	1.7	2.3	1.1	1.5	-0.5	1.5	-1.5	1.4	1.4
Total resting periods, locomotor time 1	1.8	2.0	2.5	1.2	1.6	-0.7	1.6	-1.6	1.5	1.5
Rest time, locomotor task time 1	0.0	0.0	0.1	0.0	-0.2	-0.2	-0.2	0.2	-0.2	-0.2
Distance moved, locomotor task time 1	0.8	1.3	1.5	-1.1	-1.2	1.0	-1.1	1.2	-1.1	-1.0
Vertical activity count, locomotor time 1	0.2	0.5	0.6	-0.7	-0.7	0.7	-0.7	0.8	-0.7	-0.7
Time >=10cm from walls, locomotor time 2	0.4	0.6	1.7	0.8	0.6	-1.3	0.5	-0.7	0.5	0.4
Bouts of movement, locomotor time 2	0.1	0.1	0.2	-0.5	-0.2	0.3	-0.2	0.1	-0.3	-0.3
Total resting periods, locomotor time 2	0.0	0.0	0.0	-0.2	0.1	0.1	0.2	-0.2	0.1	0.0
Rest time, locomotor task time 2	1.2	1.5	2.1	1.0	1.4	-0.8	1.3	-1.3	1.3	1.3
Distance moved, locomotor task time 2	0.9	1.1	1.3	-0.9	-1.1	0.6	-1.1	1.1	-1.1	-1.1
Vertical activity count, locomotor time 2	0.3	0.5	0.6	-0.5	-0.8	0.4	-0.8	0.8	-0.8	-0.8
Light reinforcement 1	2.3	5.7	7.5	1.8	2.7	-0.9	2.7	-2.6	2.7	2.6
Light reinforcement 2	2.7	4.1	5.2	1.8	2.3	-1.5	2.2	-2.1	2.1	2.1
Bone: marrow area	0.5	1.2	1.8	0.7	1.2	-0.2	1.2	-1.3	1.2	1.2
Bone: maximum diameter	0.9	1.7	2.5	0.6	1.5	0.1	1.5	-1.6	1.5	1.4
Bone: maximum force	0.1	0.2	0.3	0.2	0.3	-0.3	0.5	-0.6	0.5	0.5
Bone: maximum moment	0.2	0.3	0.4	0.3	0.5	-0.4	0.6	-0.6	0.6	0.6
Mean time between licks in bursts	1.6	3.8	4.1	-1.9	-1.9	1.9	-2.0	2.0	-2.0	-1.9
Mean num. licks in bursts	0.3	0.5	1.6	1.2	0.2	-1.3	0.5	-0.4	0.4	0.5
Cd content in liver	0.0	0.0	0.2	-0.1	0.0	0.4	0.1	-0.1	0.1	0.1
Co content in liver	5.9	6.8	7.7	2.4	2.8	-2.4	2.7	-2.7	2.6	2.6
Cu content in liver	0.2	0.2	0.7	0.5	0.3	-0.8	0.3	-0.2	0.3	0.3
Fe content in liver	1.1	1.3	2.9	1.3	0.8	-1.7	1.0	-0.9	1.1	1.1
K content in liver	0.3	0.3	0.4	-0.4	0.7	0.3	0.7	-0.7	0.6	0.6
Mg content in liver	0.4	0.4	0.5	-0.5	0.7	0.3	0.7	-0.7	0.7	0.6
Mn content in liver	0.3	0.3	1.4	-0.6	0.0	1.2	0.2	-0.3	0.3	0.2
Na content in liver	0.8	0.9	2.5	1.1	0.6	-1.6	0.8	-0.7	0.7	0.7
Rb content in liver	0.1	0.1	0.6	-0.6	0.0	0.8	0.0	-0.0	0.1	0.1
Se content in liver	0.1	0.2	0.3	-0.5	-0.6	0.4	-0.3	0.3	-0.3	-0.3
Sr content in liver	0.2	0.1	0.3	0.2	-0.3	-0.5	-0.3	0.4	-0.4	-0.4
Zn content in liver	0.8	0.9	1.4	-1.2	-0.9	0.7	-0.9	0.9	-1.0	-1.0
Bone: minimum diameter	0.2	0.3	1.3	-0.7	-0.0	1.1	-0.2	0.1	-0.2	-0.3
Time in familiar zone, hab. session 1	1.0	1.0	2.0	-1.1	-1.0	1.4	-0.8	0.8	-0.8	-0.8
Time in novel zone, hab. session 1	0.4	0.4	0.7	-0.3	-0.8	0.3	-0.8	0.8	-0.7	-0.7
Total zone transitions, hab. session 1	0.1	0.1	0.2	0.4	0.4	-0.3	0.4	-0.4	0.3	0.4
Total locomotion distance, hab. session 1	0.1	0.2	0.3	0.5	0.5	-0.3	0.5	-0.5	0.4	0.4
Locomotion velocity, hab. session 1	1.0	1.3	1.7	1.0	1.3	-1.0	1.2	-1.2	1.2	1.1
Time in familiar zone, hab. session 2	0.0	0.0	0.2	-0.3	-0.1	0.4	0.1	-0.1	0.1	0.1
Time in novel zone, hab. session 2	0.4	0.4	0.6	-0.4	-0.5	0.4	-0.8	0.8	-0.7	-0.7
Total zone transitions, hab. session 2	0.1	0.1	0.3	0.1	0.5	0.2	0.3	-0.3	0.3	0.3
Total locomotion distance, hab. session 2	0.1	0.2	0.5	0.1	0.7	0.1	0.5	-0.5	0.4	0.4
Locomotion velocity, hab. session 2	0.3	0.4	0.9	0.3	0.9	-0.1	0.7	-0.7	0.7	0.6
Novel to familiar place preference ratio	0.9	1.0	1.3	-1.0	-0.8	1.1	-1.1	1.0	-1.1	-1.1
Novelty place preference	1.5	1.6	1.9	-1.2	-1.1	1.4	-1.3	1.3	-1.3	-1.3
Time in novel zone, NPP test	1.7	1.9	2.1	-1.2	-1.2	1.4	-1.4	1.4	-1.4	-1.4
Total zone transitions, NPP test	1.5	2.2	2.4	1.5	1.5	-1.5	1.5	-1.4	1.4	1.5
Total locomotion distance, NPP test	2.0	2.7	3.2	1.6	1.8	-1.5	1.7	-1.6	1.6	1.6
Locomotion velocity, NPP test	3.1	4.3	5.4	1.9	2.3	-1.8	2.2	-2.1	2.1	2.1
Intraocular pressure	6.3	9.1	11.5	-3.3	-2.6	3.4	-3.0	2.9	-2.9	-2.9
Delta distance traveled before/after self-admin	2.1	2.2	3.0	-1.7	-1.6	1.7	-1.3	1.4	-1.3	-1.3
Delta ambulatory time before/after self-admin	0.4	0.5	1.5	-1.0	-0.6	1.2	-0.4	0.5	-0.4	-0.4
Parametrial fat weight	12.3	29.0	34.3	-5.9	-5.2	5.5	-5.2	5.3	-5.3	-5.3
Pavlov. Cond. lever latency	1.5	1.9	3.0	-0.9	-1.7	0.7	-1.5	1.5	-1.5	-1.4
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	-0.2	0.4	0.4	0.3	-0.3	0.3	0.3
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	-0.1	0.3	0.2	0.2	-0.2	0.2	0.2
Pavlov. Cond. index score	0.6	0.7	1.3	0.2	1.2	0.1	1.0	-1.0	0.9	0.9
Pavlov. Cond. latency score	0.6	0.7	1.3	0.1	1.1	0.2	1.0	-1.0	0.9	0.9
Pavlov. Cond. lever contacts	1.0	1.2	2.1	0.7	1.4	-0.5	1.2	-1.2	1.2	1.1
Pavlov. Cond. magazine entry number	0.3	0.4	0.7	-0.2	-0.8	-0.2	-0.8	0.7	-0.8	-0.7
Pavlov. Cond. intertrial magazine entries	1.5	1.8	3.2	1.4	1.4	-1.8	1.2	-1.1	1.2	1.3
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.4	2.4	0.6	1.5	-0.3	1.3	-1.3	1.3	1.3
Pavlov. Cond. response bias	1.1	1.4	2.1	0.8	1.4	-0.6	1.3	-1.3	1.3	1.3
Pavlov. Cond. lever latency	1.6	2.2	2.6	-1.6	-1.4	1.5	-1.4	1.5	-1.4	-1.4
Pavlov. Cond. magazine entry latency	0.3	0.3	0.5	0.6	0.5	-0.5	0.6	-0.7	0.5	0.5
Pavlov. Cond. change in total contacts	0.6	1.0	1.3	1.0	1.1	-0.9	1.0	-1.1	1.0	1.0
Pavlov. Cond. index score	1.3	1.7	1.9	1.4	1.3	-1.3	1.3	-1.4	1.2	1.2
Pavlov. Cond. latency score	1.3	1.7	2.0	1.4	1.3	-1.4	1.3	-1.4	1.2	1.2
Pavlov. Cond. lever contacts	1.1	1.5	1.7	1.3	1.2	-1.3	1.2	-1.3	1.2	1.2
Pavlov. Cond. magazine entry number	0.1	0.2	0.3	-0.3	-0.3	0.3	-0.5	0.6	-0.4	-0.4
Pavlov. Cond. intertrial magazine entries	3.5	5.2	5.6	-2.2	-2.3	2.2	-2.4	2.3	-2.3	-2.3
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.1	1.3	1.0	1.1	-1.0	1.1	-1.2	1.0	1.0
Pavlov. Cond. response bias	1.7	2.4	2.5	1.6	1.5	-1.6	1.5	-1.6	1.5	1.5
LgA PC1 addiction-like behavior	0.1	0.2	0.7	0.4	0.8	-0.3	0.3	-0.3	0.2	0.2
Time in closed arm before self-admin	0.7	0.9	1.5	-0.8	-1.2	0.8	-1.0	0.9	-1.0	-1.0
Time in closed arm after self-admin	1.5	1.6	2.5	-1.1	-1.6	1.4	-1.2	1.1	-1.2	-1.2
Time in open arm before self-admin	0.1	0.1	0.6	0.2	0.8	-0.0	0.3	-0.2	0.2	0.3
Time in open arm after self-admin	1.3	1.4	2.5	0.8	1.6	-0.6	1.3	-1.2	1.3	1.3
Bone: periosteal estimation	0.8	1.7	2.5	0.8	1.6	-0.2	1.5	-1.6	1.5	1.4
Bone: periosteal perimeter	0.4	0.6	0.9	0.3	0.9	-0.2	0.9	-1.0	0.9	0.9
Bone: post-yield work	1.0	1.5	2.2	1.5	0.9	-1.5	1.2	-1.1	1.1	1.2
Progressive ratio test 1 active lever presses	1.9	2.3	4.0	1.6	1.7	-2.0	1.2	-1.4	1.3	1.3
Progressive ratio test 1 breakpoint	1.9	2.3	3.9	1.6	1.7	-2.0	1.2	-1.4	1.3	1.3
Progressive ratio test 1 inactive lever presses	3.0	4.4	6.0	2.2	1.9	-2.4	2.0	-2.0	2.0	2.0
Progressive ratio test 2 active lever presses	0.7	0.8	2.7	1.3	0.4	-1.6	0.5	-0.5	0.4	0.4
Progressive ratio test 2 breakpoint	0.6	0.6	2.4	1.2	0.3	-1.5	0.4	-0.4	0.3	0.3
Progressive ratio test 2 inactive lever presses	1.3	2.2	3.4	1.7	1.1	-1.8	1.4	-1.5	1.4	1.3
ShA PR total presses	2.0	2.3	2.7	1.5	1.6	-1.5	1.5	-1.5	1.5	1.5
Incentive Sensitization - Responses	0.2	0.3	0.8	0.8	0.1	-0.9	0.3	-0.3	0.3	0.3
Incentive Sensitization - Breakpoint	0.1	0.2	0.5	0.7	-0.1	-0.7	0.2	-0.1	0.1	0.2
LgA PR total presses	0.8	0.9	1.8	0.9	1.3	-0.4	0.9	-1.0	0.9	0.9
Sum of active levers in priming session hrs 5-6	0.6	0.6	1.4	-0.4	1.2	0.7	0.7	-0.7	0.7	0.7
Progressive ratio	0.0	0.1	0.2	-0.1	-0.4	0.4	-0.1	0.1	-0.1	-0.1
Food seeking constrained by brief footshock	4.3	5.3	8.0	2.8	2.1	-2.8	2.1	-2.1	2.1	2.1
Seeking ratio, punishment vs. effort	0.5	0.8	1.6	0.9	1.1	-1.3	0.7	-0.7	0.7	0.7
Retroperitoneal fat weight	24.2	103.0	126.7	-10.8	-9.7	11.3	-9.9	9.7	-9.7	-9.8
Reaction time number correct	0.4	0.9	1.0	1.0	1.0	-0.7	1.0	-1.0	0.9	0.9
Reaction time mean minus median	0.0	0.0	0.1	0.3	-0.0	-0.3	-0.1	0.0	-0.0	-0.0
Reaction time mean minus median AUC	0.0	0.1	0.1	-0.2	-0.2	0.1	-0.3	0.3	-0.3	-0.3
Reaction time num false alarms	0.4	0.5	2.4	-1.1	0.4	1.6	-0.0	-0.0	0.0	0.0
Reaction time num false alarms AUC	0.4	0.6	2.5	-1.1	0.6	1.6	0.0	-0.1	0.1	0.0
Reaction time trials correct on left	0.4	0.9	1.0	1.0	1.0	-0.7	1.0	-1.0	0.9	0.9
Reaction time trials on left	0.5	0.9	1.0	1.0	1.0	-0.7	1.0	-1.0	0.9	0.9
Reaction time mean	0.9	1.4	1.9	-1.0	-1.1	0.6	-1.3	1.3	-1.4	-1.4
Reaction time mean AUC	0.7	1.1	1.6	-0.9	-0.9	0.5	-1.2	1.2	-1.3	-1.2
Median of all reaction times	1.1	1.6	2.1	-1.2	-1.1	0.7	-1.4	1.4	-1.5	-1.5
Reaction time omissions	0.1	0.2	0.6	-0.4	0.6	0.8	0.2	-0.3	0.3	0.3
Reaction time false alarm rate	0.6	0.9	3.1	-1.5	0.1	1.8	-0.5	0.4	-0.4	-0.4
Reaction time premature initiation rate	0.1	0.1	0.2	-0.2	-0.4	0.0	-0.5	0.4	-0.5	-0.4
Reaction time premature initiations	0.0	0.0	0.1	0.3	0.1	-0.3	0.1	-0.1	0.1	0.1
Std. dev. reaction times	0.2	0.4	0.5	-0.4	-0.6	0.4	-0.7	0.6	-0.7	-0.7
Reaction time trials completed	0.5	0.9	1.0	1.0	1.0	-0.7	1.0	-1.0	0.9	0.9
Reaction time trials AUC	0.6	1.1	1.3	1.2	1.1	-0.9	1.1	-1.1	1.1	1.1
Run reversals in cocaine runway, females	0.1	0.1	0.5	0.4	0.1	-0.7	-0.2	0.3	-0.2	-0.2
Run reversals in cocaine runway, males	0.2	0.2	1.0	0.7	0.2	-1.0	0.2	-0.1	0.2	0.3
Latency to leave start box in cocaine runway	0.7	0.8	1.4	1.0	0.9	-1.2	0.8	-0.9	0.8	0.8
Latency to leave start box in cocaine runway, F	0.3	0.4	1.0	0.4	1.0	-0.4	0.5	-0.6	0.5	0.5
Latency to leave start box in cocaine runway, M	0.5	0.5	1.8	1.1	-0.2	-1.3	0.3	-0.2	0.2	0.2
Std. dev. time between licks in bursts	0.5	0.6	2.7	-1.2	-0.2	1.6	-0.3	0.3	-0.3	-0.3
Total sessions with >9 infusions	1.1	1.3	3.0	1.6	0.6	-1.7	0.8	-1.0	0.9	0.9
Short access day 1 total inactive lever presses	6.4	8.4	11.1	2.3	3.3	-2.1	3.1	-3.1	3.1	3.0
Short access day 10 total inactive lever presses	1.6	3.8	5.0	1.5	2.2	-1.6	2.0	-2.0	2.1	2.1
Short access day 1 total infusions	3.6	4.7	5.9	2.4	1.9	-2.2	2.1	-2.3	2.2	2.1
Short access day 10 total infusions	2.5	3.2	4.9	1.9	1.8	-2.2	1.6	-1.6	1.6	1.6
Short access total infusions	1.3	1.6	2.6	1.6	0.9	-1.6	1.1	-1.2	1.1	1.1
ShA early post infusion interval	0.4	0.3	0.9	-0.7	-0.4	0.9	-0.4	0.5	-0.5	-0.5
ShA late post infusion interval	3.0	3.0	5.1	-1.6	-2.3	1.5	-1.6	1.6	-1.6	-1.7
ShA early loading	0.2	0.2	0.5	-0.2	0.7	-0.0	0.4	-0.4	0.5	0.4
ShA late loading	0.6	0.8	1.4	0.5	1.2	-0.2	1.0	-1.0	1.0	1.0
Short access day 1 locomotion	3.0	3.8	5.6	2.4	1.6	-2.3	1.8	-1.9	1.8	1.8
Short access day 10 total locomotion	1.3	2.3	3.7	1.7	1.4	-1.9	1.4	-1.4	1.4	1.4
Short access total locomotion	0.3	0.4	1.3	0.9	0.3	-1.1	0.4	-0.4	0.4	0.4
ShA early average infusions	1.3	1.6	2.0	1.0	1.4	-1.3	1.2	-1.4	1.2	1.2
ShA late average infusions	2.3	2.4	3.0	1.4	1.7	-1.2	1.6	-1.7	1.6	1.5
ShA early timeout	0.4	0.4	0.6	0.3	0.8	-0.7	0.6	-0.7	0.6	0.6
ShA late timeout	1.9	2.1	2.7	1.5	1.3	-1.6	1.4	-1.4	1.4	1.4
ShA early titration	0.2	0.2	0.4	0.3	0.6	-0.6	0.4	-0.5	0.4	0.4
ShA late titration	2.0	2.1	2.4	1.3	1.6	-1.3	1.5	-1.5	1.5	1.4
ShA total infusions	1.1	1.3	2.1	1.0	1.4	-1.0	1.1	-1.2	1.1	1.1
One hour access (0.3 mA shock)	1.6	1.9	4.0	1.8	1.0	-2.0	1.2	-1.1	1.1	1.1
Shock compulsivity	0.7	1.4	2.1	1.1	1.4	-1.4	1.1	-1.1	0.9	0.9
Compulsive drug intake	1.2	1.5	3.8	-1.6	-0.5	2.0	-0.9	1.1	-0.9	-0.9
One hour access (shock baseline)	2.3	3.5	7.6	2.4	1.3	-2.8	1.6	-1.6	1.5	1.5
Social response proportion	0.2	0.3	0.4	-0.2	-0.6	-0.3	-0.6	0.5	-0.6	-0.6
Social responses	0.0	0.1	0.1	-0.3	-0.1	0.1	-0.3	0.2	-0.3	-0.4
Social time	0.2	0.3	0.6	-0.1	-0.7	0.0	-0.6	0.5	-0.7	-0.8
Soleus weight	4.6	13.5	15.8	3.6	4.0	-3.2	3.8	-3.7	3.7	3.7
Bone: stiffness	0.0	0.0	0.0	-0.1	0.1	0.1	0.2	-0.2	0.1	0.1
Tibialis anterior weight	3.5	11.9	14.2	3.2	3.8	-2.5	3.6	-3.6	3.6	3.6
Time to tail flick, vehicle, before self-admin	0.9	0.9	1.3	-0.3	-1.2	0.4	-1.1	1.1	-1.1	-1.1
Time to tail flick, vehicle, after self-admin	3.3	4.3	5.4	-1.8	-2.3	1.6	-2.2	2.1	-2.2	-2.2
Time to tail flick, test, before self-admin	0.0	0.0	0.1	0.2	-0.0	0.1	0.2	-0.2	0.3	0.3
Time to tail flick, test, after self-admin	0.3	0.3	1.1	1.0	0.4	-0.9	0.3	-0.3	0.2	0.3
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.3	-0.5	-0.4	0.5	-0.3	0.2	-0.2	-0.3
Delta time to tail flick, test, before/after SA	2.0	2.0	2.8	1.6	1.6	-1.7	1.3	-1.2	1.2	1.2
Tibia length	2.7	7.5	8.0	-2.7	-2.8	2.6	-2.7	2.7	-2.7	-2.8
Ambulatory time before self-admin	0.1	0.1	0.6	0.5	-0.1	-0.8	0.1	-0.0	0.0	0.0
Ambulatory time after self-admin	1.3	1.6	2.8	-1.2	-1.7	0.8	-1.2	1.3	-1.2	-1.2
Bone: tissue strength	0.8	0.8	1.2	-0.6	-1.1	0.5	-1.0	1.0	-1.0	-0.9
Total heroin consumption	2.7	3.2	4.7	1.5	2.2	-1.1	1.9	-1.9	1.9	1.9
Total infusions	0.1	0.1	0.1	-0.1	0.2	0.3	-0.3	0.1	-0.3	-0.4
Bone: trabecular number	3.3	5.4	7.6	2.0	2.7	-1.7	2.5	-2.4	2.4	2.4
Bone: trabecular spacing	2.8	3.7	4.8	-1.6	-2.2	1.3	-2.1	2.2	-2.1	-2.0
Bone: trabecular thickness	0.7	0.8	1.2	0.5	1.1	-0.5	1.0	-1.1	1.0	0.9
Bone: trabecular tissue density	0.3	0.4	0.5	0.6	0.5	-0.7	0.7	-0.6	0.7	0.7
Water consumed over 24 hours	0.4	0.5	1.2	0.0	1.1	0.1	0.8	-0.8	0.8	0.7
Number of responses in last shaping day	0.2	0.2	0.5	0.7	-0.3	-0.5	0.4	-0.4	0.4	0.3