Itsn2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	Itsn2	0.02	0.01	1.3e-03	0.02	0.03	0.02	0.02	1.4e-03	5.8e-04	1.2e-03	1.6e-03
2	Adipose	gene expression	Itsn2	0.02	0.02	9.7e-03	0	0	-0	-0	3.1e-01	1.4e-01	4.3e-01	3.9e-01
3	PL	intron excision ratio	chr6_27617212_27638176	0.02	0.01	6.4e-03	0.02	0.01	0.01	0.01	3.9e-03	3.3e-02	1.2e-02	1.4e-02
4	Brain	mRNA stability	Itsn2	0.03	0.02	6.1e-03	0	0.01	0.01	0.01	1.8e-01	2.1e-02	3.9e-02	7.3e-02
5	Brain	gene expression	Itsn2	0.03	0.02	6.3e-03	0.03	0.02	0.01	0.02	2.0e-03	7.1e-03	3.2e-02	4.6e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	4.5	7.6	11.1	-2.7	-3.2	-2.2	3.3	2.1
Area under the delay curve	0.0	0.0	0.1	0.2	0.2	0.1	-0.3	0.0
BMI with tail	4.1	13.1	15.1	3.8	3.7	3.9	-3.5	-3.3
BMI without tail	1.9	3.9	4.5	1.9	2.1	1.6	-2.1	-2.1
Body weight	3.9	16.1	17.6	4.2	4.1	4.1	-3.9	-3.8
Weight adjusted by age	1.3	1.5	2.0	1.3	1.1	1.2	-1.0	-1.4
Bone surface	1.3	2.2	3.2	-1.5	-1.7	-0.9	1.8	1.4
Bone volume	2.8	4.7	6.4	-2.1	-2.5	-1.6	2.5	2.0
Breakpoint value in progressive ratio session	2.2	2.4	2.9	-1.5	-1.7	-1.4	1.7	1.4
Number of licking bursts	2.4	2.8	3.1	1.6	1.7	1.8	-1.6	-1.7
Context. condit. distance diff. score	0.5	0.6	1.4	-0.6	-1.0	-0.2	1.2	0.4
Locomotion velocity, session 1	0.3	0.3	0.6	0.4	0.5	0.4	-0.4	-0.8
Locomotion distance, session 1	0.4	0.5	0.7	-0.8	-0.7	-0.8	0.7	0.4
Locomotion velocity, session 2	0.5	0.5	1.1	0.7	0.7	1.1	-0.7	-0.3
Locomotion distance, session 2	0.0	0.0	0.1	0.1	0.2	0.1	-0.3	-0.2
Locomotion velocity, session 3	0.0	0.0	0.1	0.0	-0.1	-0.0	0.2	-0.3
Locomotion distance, session 3	0.0	0.0	0.1	-0.0	-0.2	0.1	0.3	-0.2
Stereotopy head waving bouts, day 3	3.9	4.6	5.4	-2.0	-2.3	-2.2	2.3	1.8
Stereotopy head waving duration, day 3	0.7	0.9	1.2	-0.9	-1.0	-1.1	1.0	0.8
Locomotion velocity, session 7	0.1	0.1	0.2	0.2	-0.0	0.4	0.1	0.2
Locomotion distance, session 7	0.5	0.7	1.1	1.0	0.8	0.9	-0.6	-0.7
Stereotopy head waving bouts, day 7	0.0	0.0	0.0	-0.2	0.0	0.1	-0.1	-0.2
Stereotopy head waving duration, day 7	0.2	0.2	0.4	-0.7	-0.5	-0.5	0.4	0.3
Locomotion velocity, session 8	0.7	0.8	1.6	-0.8	-1.2	-0.4	1.2	0.6
Locomotion distance, session 8	1.4	2.0	2.9	-1.4	-1.7	-1.1	1.7	1.1
Degree of sensitization distance	1.1	1.1	1.6	1.3	1.1	1.0	-1.1	-0.8
Degree of sensitization stereotypy	0.8	0.9	1.3	0.6	1.0	0.9	-1.1	-0.9
Conditioned locomotion	2.6	3.0	4.6	-1.7	-2.0	-1.5	2.1	1.1
Cocaine response after cond. corrected	0.0	0.1	0.1	-0.1	0.2	-0.1	-0.3	-0.3
Cocaine response after cond. not corrected	0.2	0.2	0.4	-0.6	-0.1	-0.7	-0.0	0.3
Cocaine response before conditioning	1.6	1.9	3.1	-1.4	-1.2	-1.4	1.1	1.8
Saline control response	1.7	2.3	2.6	-1.6	-1.5	-1.6	1.4	1.3
Bone: connectivity density	2.6	4.1	6.2	-2.0	-2.4	-1.6	2.5	1.4
Bone: cortical apparent density	0.1	0.1	0.3	-0.3	-0.1	-0.5	-0.1	0.1
Bone: cortical area	0.1	0.1	0.2	0.3	0.5	0.3	-0.5	-0.3
Bone: cortical porosity	2.0	2.2	2.3	-1.5	-1.5	-1.4	1.4	1.5
Bone: cortical porosity	1.4	1.6	1.8	-1.3	-1.3	-1.1	1.2	1.4
Bone: cortical thickness	0.4	0.7	1.4	0.6	1.1	0.4	-1.2	-0.5
Bone: cortical thickness	0.7	0.8	1.3	-0.9	-0.7	-1.0	0.6	1.1
Bone: cortical tissue density	0.0	0.1	0.2	-0.2	0.0	-0.4	-0.2	-0.0
Condit. Reinf. active minus inactive responses	4.0	4.5	5.2	2.1	2.3	1.8	-2.3	-2.1
Condit. Reinf. active-inactive response ratio	2.5	2.8	3.3	1.7	1.8	1.3	-1.7	-1.8
Condit. Reinf. active responses	0.7	0.9	1.0	0.9	1.0	0.8	-1.0	-1.0
Condit. Reinf. inactive responses	1.1	1.3	1.5	-1.2	-1.2	-1.0	1.2	1.2
Incentive salience index mean	1.6	1.9	2.2	1.3	1.5	1.2	-1.5	-1.4
Condit. Reinf. lever presses	0.0	0.0	0.1	-0.3	-0.1	-0.1	-0.0	0.1
Condit. Reinf. active minus inactive responses	0.6	0.7	1.5	-0.9	-0.7	-1.2	0.7	0.4
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.1	-0.3	-0.1	-0.4	0.1	0.0
Condit. Reinf. active responses	0.2	0.3	0.9	-0.5	-0.2	-1.0	0.1	0.1
Condit. Reinf. inactive responses	0.1	0.1	0.3	-0.2	-0.0	-0.5	-0.0	-0.2
Condit. Reinf. lever presses	0.4	0.6	1.6	-0.9	-0.5	-1.2	0.2	0.5
Condit. Reinf. lever reinforcers received	0.2	0.2	0.9	-0.5	-0.1	-0.9	-0.0	0.1
Conditioned reinforcement - actives	4.1	4.1	4.7	-2.1	-2.0	-2.0	1.8	2.2
Conditioned reinforcement - inactives	5.9	6.6	8.1	-2.9	-2.5	-2.6	2.3	2.5
Conditioned locomotion	4.1	5.0	7.8	-2.2	-1.8	-2.6	1.4	2.8
Patch foraging indifference point 0 sec	0.0	0.1	0.2	0.0	-0.3	0.3	0.4	0.2
Patch foraging indifference point AUC	0.1	0.1	0.2	0.0	-0.2	0.0	0.3	-0.5
Delay disc. indifference point, 0s delay	0.3	0.3	0.8	0.3	0.7	0.4	-0.9	-0.1
Delay disc. indifference point, 16s delay	0.0	0.0	0.0	-0.0	-0.0	-0.0	-0.0	0.0
Delay disc. indifference point, 2s delay	0.1	0.1	0.4	0.1	0.4	-0.1	-0.6	0.4
Delay disc. indifference point, 24s delay	2.3	2.3	2.6	-1.5	-1.6	-1.5	1.5	1.3
Delay disc. indifference point, 4s delay	0.0	0.0	0.1	0.1	0.2	0.0	-0.2	0.2
Delay disc. indifference point, 8s delay	0.0	0.0	0.0	0.0	-0.0	-0.0	0.0	0.1
Indifference point function ln k	1.6	2.3	3.1	-1.7	-1.4	-1.5	1.2	1.8
Indifference point function log k	1.6	2.3	3.1	-1.7	-1.4	-1.5	1.2	1.8
Patch foraging total patch changes 0 sec	0.1	0.1	0.3	-0.1	-0.4	0.1	0.5	0.2
Patch foraging total patch changes 12 sec	1.1	1.5	2.0	1.3	1.1	1.3	-0.8	-1.4
Patch foraging total patch changes 18 sec	0.1	0.1	0.3	0.3	-0.3	0.4	0.5	-0.4
Patch foraging total patch changes 24 sec	0.5	0.7	1.1	0.8	0.7	0.9	-0.5	-1.1
Patch foraging total patch changes 6 sec	0.7	1.0	1.7	1.1	0.8	1.2	-0.5	-1.3
Patch foraging time to switch 0 sec	0.5	0.8	1.1	1.1	1.0	0.7	-1.0	-0.6
Patch foraging water rate 0 sec	3.0	4.8	5.5	-2.3	-2.3	-2.1	2.3	1.9
Patch foraging water rate 12 sec	0.1	0.2	0.4	0.1	0.5	-0.2	-0.6	-0.3
Patch foraging water rate 18 sec	2.4	3.2	4.4	-2.1	-1.6	-2.1	1.3	1.8
Patch foraging water rate 24 sec	0.0	0.0	0.0	0.1	-0.0	0.1	0.1	0.0
Patch foraging water rate 6 sec	0.7	1.0	2.0	-1.2	-0.8	-1.4	0.6	0.7
Seeking ratio, delayed vs. immediate footshock	0.3	0.4	0.5	0.7	0.7	0.6	-0.6	-0.5
Distance traveled before self-admin	0.0	0.0	0.2	0.0	0.1	-0.4	-0.1	-0.0
Distance traveled after self-admin	0.1	0.1	0.2	-0.1	-0.3	-0.4	0.4	0.1
Extensor digitorum longus weight	1.5	6.0	7.0	-2.6	-2.5	-2.6	2.4	2.1
Bone: elastic displacement	1.9	2.2	3.2	-1.5	-1.4	-1.8	1.3	1.3
Bone: elastic work	1.5	1.9	2.7	-1.4	-1.2	-1.5	1.1	1.6
Bone: endosteal estimation	0.3	0.8	1.4	-0.8	-1.1	-0.4	1.2	0.7
Bone: endosteal perimeter	0.0	0.1	0.1	0.1	-0.2	0.3	0.4	-0.0
Epididymis fat weight	21.4	49.8	57.4	7.6	7.1	7.4	-6.6	-6.6
Delta time in closed arm before/after self-admin	0.1	0.1	0.2	0.3	0.1	0.4	0.1	-0.5
Delta time in open arm before/after self-admin	0.3	0.3	0.3	0.5	0.6	0.5	-0.5	-0.4
Diff in mean of infusions in LGA sessions	0.3	0.3	0.7	0.5	0.3	0.9	-0.2	-0.8
Delay discount exponential model param	0.0	0.0	0.0	0.0	0.1	0.1	-0.0	-0.2
Extinction: sum of active levers before priming	0.1	0.1	0.1	-0.2	-0.4	0.3	0.4	-0.0
Active lever presses in extinction session 6	0.2	0.2	0.3	-0.2	-0.4	-0.2	0.5	-0.6
Bone: final force	0.1	0.2	0.3	0.4	0.6	0.5	-0.6	-0.1
Bone: final moment	0.1	0.1	0.2	0.3	0.4	0.4	-0.4	-0.0
Food consumed during 24 hour testing period	0.0	0.0	0.0	-0.2	-0.1	-0.1	0.1	-0.0
Glucose	0.2	0.3	0.8	0.5	0.4	0.2	-0.3	-0.9
Heart weight	4.0	5.7	6.6	2.5	2.6	2.2	-2.5	-2.1
Delay discount hyperbolic model param	0.0	0.0	0.0	0.0	-0.0	0.0	0.1	-0.2
Intermittent access intake day 1-15 change	5.6	5.6	6.5	-2.4	-2.2	-2.6	2.1	2.5
Intermittent access intake escalation	4.6	4.5	5.0	-2.1	-2.1	-2.2	2.1	2.2
Intermittent access intake escalation 2	1.4	1.4	1.7	-1.0	-1.1	-1.3	1.2	1.2
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.1	-0.0	0.2	0.3	-0.2	-0.3
Intermitt. access day 15 inactive lever presses	0.5	0.6	1.0	-0.9	-0.9	-0.5	1.0	0.2
Intermitt. access escalation Index	1.7	1.5	2.2	1.4	1.4	0.7	-1.5	-0.9
Intermittent access day 1 total infusions	1.1	1.2	1.7	-1.3	-1.1	-1.1	0.9	1.1
Intermittent access day 15 total infusions	3.3	3.7	4.4	-2.1	-1.8	-2.1	1.6	2.1
Intermittent access terminal intake (last 3 days)	2.5	2.7	4.1	-1.8	-1.3	-1.8	1.0	2.0
Intermittent access total infusions	1.7	1.9	2.4	-1.5	-1.2	-1.5	1.0	1.6
Intermittent access day 1 locomotion	1.7	1.8	2.7	-1.5	-1.1	-1.5	0.7	1.6
Intermittent access day 15 total locomotion	0.5	0.5	1.0	-0.8	-0.5	-0.9	0.3	1.0
Intermittent access total locomotion	0.7	0.8	1.5	-1.0	-0.6	-1.1	0.2	1.2
Intermittent access standard deviation	0.5	0.6	0.7	-0.7	-0.7	-0.9	0.7	0.7
Left kidney weight	0.1	0.2	0.4	-0.4	-0.2	-0.6	0.1	0.5
Right kidney weight	0.5	1.5	1.8	1.3	1.3	1.1	-1.2	-1.2
Cocaine induced anxiety	1.9	2.1	3.5	-1.3	-1.7	-1.1	1.9	1.2
Post-drug Anxiety	0.1	0.1	0.3	0.2	-0.1	0.5	0.3	-0.5
Baseline Anxiety	2.0	2.1	2.6	1.4	1.6	1.3	-1.6	-1.4
Tail length	0.1	0.4	0.9	-0.7	-0.5	-0.9	0.5	0.2
Length with tail	0.2	0.8	1.1	0.9	1.0	0.7	-1.0	-0.8
Length without tail	0.2	0.4	0.8	0.7	0.6	0.9	-0.6	-0.2
Times rat made contact with spout	1.3	1.5	2.3	-1.2	-1.5	-0.8	1.5	1.0
Lifetime Intake	2.1	2.4	3.2	-1.7	-1.4	-1.8	1.2	1.6
Liver weight, left	2.5	3.9	5.7	1.8	2.3	1.4	-2.4	-1.9
Liver weight, right	5.3	8.8	9.7	3.1	3.0	3.0	-2.9	-2.8
Locomotor activity	3.0	4.7	5.6	2.1	2.2	2.2	-2.0	-2.4
Locomotor testing distance	2.1	3.5	5.9	1.8	1.7	1.8	-1.5	-2.4
Locomotor testing rearing	0.2	0.4	0.9	0.5	0.5	0.4	-0.5	-1.0
Locomotion in novel chamber	2.6	3.2	4.3	1.6	2.0	1.6	-2.1	-1.6
Locomotion in novel chamber post-restriction	0.6	0.7	1.1	0.8	0.9	0.6	-1.1	-0.5
Fecal boli incidents, locomotor time 1	3.9	4.3	4.9	-2.1	-2.1	-2.0	2.0	2.2
Change in fecal boli incidents, locomotor task	1.9	1.8	2.4	1.6	1.5	1.1	-1.4	-1.2
Time >=10cm from walls, locomotor time 1	0.4	0.4	0.6	-0.5	-0.7	-0.4	0.8	0.6
Bouts of movement, locomotor time 1	0.3	0.3	0.4	-0.6	-0.6	-0.4	0.6	0.6
Total resting periods, locomotor time 1	0.6	0.7	1.0	-0.8	-0.9	-0.7	1.0	0.7
Rest time, locomotor task time 1	0.4	0.4	0.5	-0.6	-0.6	-0.7	0.6	0.6
Distance moved, locomotor task time 1	1.1	1.2	1.3	1.1	1.1	1.1	-1.2	-1.0
Vertical activity count, locomotor time 1	0.2	0.3	0.6	0.4	0.7	0.3	-0.8	-0.1
Time >=10cm from walls, locomotor time 2	2.1	2.2	2.6	-1.4	-1.6	-1.2	1.6	1.6
Bouts of movement, locomotor time 2	0.0	0.0	0.0	0.0	0.1	0.1	-0.1	0.2
Total resting periods, locomotor time 2	0.0	0.0	0.0	-0.0	-0.0	0.1	-0.0	0.2
Rest time, locomotor task time 2	0.0	0.1	0.1	-0.1	-0.3	0.2	0.4	0.1
Distance moved, locomotor task time 2	0.1	0.1	0.3	0.0	0.3	-0.2	-0.5	0.1
Vertical activity count, locomotor time 2	0.2	0.2	0.4	-0.4	-0.3	-0.6	0.1	0.6
Light reinforcement 1	0.2	0.5	1.3	-0.8	-0.5	-1.1	0.4	-0.1
Light reinforcement 2	2.6	3.5	4.7	-2.1	-1.8	-2.2	1.5	1.8
Bone: marrow area	0.3	0.7	1.3	-0.7	-1.0	-0.4	1.1	0.8
Bone: maximum diameter	0.1	0.2	0.4	-0.3	-0.5	-0.1	0.6	0.4
Bone: maximum force	0.1	0.1	0.1	0.3	0.4	0.4	-0.4	0.1
Bone: maximum moment	0.0	0.0	0.0	0.1	0.2	0.2	-0.2	0.2
Mean time between licks in bursts	1.3	1.8	2.2	1.4	1.2	1.5	-1.1	-1.5
Mean num. licks in bursts	4.2	5.0	5.8	-2.2	-2.4	-2.1	2.4	2.1
Cd content in liver	0.0	0.0	0.1	-0.0	-0.2	0.1	0.3	-0.1
Co content in liver	1.9	2.3	3.1	-1.7	-1.3	-1.5	1.1	1.8
Cu content in liver	0.7	0.9	1.3	1.0	0.8	1.1	-0.6	-1.1
Fe content in liver	0.7	0.9	1.7	-0.8	-1.1	-0.8	1.3	0.5
K content in liver	2.4	2.3	2.8	1.7	1.5	1.6	-1.3	-1.5
Mg content in liver	0.9	1.0	1.3	1.1	1.0	1.0	-0.8	-0.9
Mn content in liver	0.1	0.1	0.3	0.2	0.4	0.1	-0.5	0.2
Na content in liver	2.7	2.8	4.0	-1.9	-1.6	-2.0	1.4	1.5
Rb content in liver	0.4	0.4	0.9	0.8	0.4	0.7	-0.1	-1.0
Se content in liver	0.6	0.8	0.9	1.0	0.9	0.9	-0.9	-0.8
Sr content in liver	0.0	0.0	0.1	-0.0	-0.1	0.2	0.1	0.1
Zn content in liver	6.1	6.7	7.2	2.5	2.7	2.6	-2.6	-2.5
Bone: minimum diameter	1.1	2.0	2.6	1.4	1.5	1.6	-1.4	-1.1
Time in familiar zone, hab. session 1	1.9	1.8	2.1	1.4	1.4	1.5	-1.4	-1.1
Time in novel zone, hab. session 1	0.1	0.1	0.2	0.4	0.1	0.4	-0.0	-0.4
Total zone transitions, hab. session 1	0.3	0.4	0.4	-0.7	-0.7	-0.7	0.7	0.5
Total locomotion distance, hab. session 1	0.7	1.0	1.4	-1.2	-1.0	-1.1	0.8	0.9
Locomotion velocity, hab. session 1	1.5	2.1	2.9	-1.7	-1.3	-1.7	1.1	1.4
Time in familiar zone, hab. session 2	0.1	0.1	0.1	0.3	0.3	0.3	-0.2	-0.3
Time in novel zone, hab. session 2	0.2	0.2	0.3	0.5	0.3	0.6	-0.2	-0.4
Total zone transitions, hab. session 2	0.1	0.1	0.4	-0.2	-0.5	0.1	0.6	0.2
Total locomotion distance, hab. session 2	0.1	0.1	0.4	-0.2	-0.5	0.1	0.6	0.1
Locomotion velocity, hab. session 2	0.1	0.2	0.5	-0.3	-0.5	-0.0	0.7	0.1
Novel to familiar place preference ratio	0.0	0.0	0.0	-0.1	-0.1	-0.1	0.1	-0.1
Novelty place preference	0.1	0.1	0.2	0.2	0.3	0.3	-0.3	-0.5
Time in novel zone, NPP test	0.1	0.1	0.3	0.3	0.3	0.4	-0.2	-0.5
Total zone transitions, NPP test	0.4	0.6	1.2	-0.7	-1.0	-0.5	1.1	0.4
Total locomotion distance, NPP test	1.3	1.8	2.5	-1.3	-1.5	-1.1	1.6	1.1
Locomotion velocity, NPP test	1.7	2.4	3.0	-1.6	-1.7	-1.5	1.7	1.2
Intraocular pressure	2.7	3.8	4.7	2.2	2.0	1.9	-1.9	-1.8
Delta distance traveled before/after self-admin	0.5	0.6	1.0	0.8	0.5	0.9	-0.4	-1.0
Delta ambulatory time before/after self-admin	0.1	0.1	0.3	-0.2	-0.4	-0.0	0.5	0.2
Parametrial fat weight	17.3	33.7	38.5	5.9	6.2	5.2	-6.0	-5.6
Pavlov. Cond. lever latency	0.0	0.0	0.1	0.3	0.3	0.0	-0.3	0.0
Pavlov. Cond. magazine entry latency	0.2	0.3	0.7	0.4	0.1	0.8	0.1	-0.9
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	-0.1	-0.0	0.2	-0.0	0.0
Pavlov. Cond. index score	0.1	0.1	0.3	0.0	-0.1	0.6	0.2	-0.3
Pavlov. Cond. latency score	0.1	0.1	0.3	0.0	-0.2	0.6	0.3	-0.3
Pavlov. Cond. lever contacts	0.1	0.1	0.1	-0.3	-0.3	0.1	0.3	0.0
Pavlov. Cond. magazine entry number	0.1	0.1	0.3	0.1	0.3	-0.4	-0.4	0.5
Pavlov. Cond. intertrial magazine entries	1.2	1.5	1.9	-1.1	-1.2	-1.2	1.1	1.4
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.3	-0.4	-0.5	0.1	0.6	0.1
Pavlov. Cond. response bias	0.5	0.6	1.1	-0.8	-1.0	-0.4	1.0	0.3
Pavlov. Cond. lever latency	0.7	1.0	1.1	1.0	1.0	1.0	-1.0	-0.8
Pavlov. Cond. magazine entry latency	0.0	0.1	0.1	-0.0	-0.2	-0.3	0.3	-0.2
Pavlov. Cond. change in total contacts	0.0	0.1	0.1	-0.1	-0.2	-0.4	0.2	-0.2
Pavlov. Cond. index score	0.5	0.6	0.9	-0.7	-0.8	-0.9	0.8	0.5
Pavlov. Cond. latency score	0.6	0.7	0.9	-0.8	-0.9	-1.0	0.9	0.6
Pavlov. Cond. lever contacts	0.1	0.1	0.2	-0.3	-0.3	-0.4	0.3	0.2
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	-0.5	-0.2	-0.2	0.0	0.4
Pavlov. Cond. intertrial magazine entries	1.2	1.6	2.2	1.2	1.4	1.4	-1.5	-0.7
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.5	-0.5	-0.6	-0.7	0.6	0.4
Pavlov. Cond. response bias	0.3	0.4	0.5	-0.5	-0.7	-0.7	0.7	0.3
Time in closed arm before self-admin	0.0	0.0	0.0	-0.0	-0.1	-0.2	0.2	-0.1
Time in closed arm after self-admin	1.3	1.3	1.7	1.0	1.1	1.2	-1.2	-1.3
Time in open arm before self-admin	0.1	0.1	0.3	0.2	0.5	0.2	-0.6	0.2
Time in open arm after self-admin	0.2	0.2	0.4	-0.3	-0.3	-0.4	0.3	0.7
Bone: periosteal estimation	0.2	0.3	0.5	-0.5	-0.6	-0.3	0.7	0.6
Bone: periosteal perimeter	0.0	0.0	0.1	0.1	-0.0	0.2	0.1	-0.0
Bone: post-yield work	1.2	1.6	2.4	-1.1	-1.5	-1.0	1.6	1.2
Progressive ratio test 1 active lever presses	0.3	0.3	0.6	-0.8	-0.5	-0.7	0.2	0.3
Progressive ratio test 1 breakpoint	0.2	0.2	0.6	-0.7	-0.4	-0.5	0.2	0.4
Progressive ratio test 1 inactive lever presses	1.6	1.7	2.2	-1.5	-1.4	-1.4	1.3	1.1
Progressive ratio test 2 active lever presses	2.0	2.2	2.9	-1.5	-1.3	-1.6	1.1	1.7
Progressive ratio test 2 breakpoint	2.1	2.4	3.2	-1.6	-1.4	-1.7	1.2	1.8
Progressive ratio test 2 inactive lever presses	3.8	4.4	5.1	-2.2	-2.0	-2.3	1.9	2.1
Incentive Sensitization - Responses	2.3	2.3	4.1	-1.4	-1.1	-1.8	0.9	2.0
Incentive Sensitization - Breakpoint	1.7	1.7	3.4	-1.2	-0.9	-1.6	0.6	1.8
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	-0.3	-0.4	-0.1	0.5	0.1
Progressive ratio	0.1	0.1	0.3	0.3	0.1	0.5	0.1	-0.1
Food seeking constrained by brief footshock	8.0	9.8	11.1	-3.1	-3.3	-2.9	3.3	3.0
Seeking ratio, punishment vs. effort	2.1	2.5	3.0	-1.6	-1.6	-1.7	1.5	1.4
Retroperitoneal fat weight	37.2	122.3	133.0	11.5	11.5	10.6	-11.0	-10.6
Reaction time number correct	0.2	0.3	0.5	-0.7	-0.7	-0.4	0.7	0.4
Reaction time mean minus median	1.7	2.2	2.7	1.5	1.5	1.6	-1.3	-1.6
Reaction time mean minus median AUC	1.9	2.4	3.5	1.5	1.5	1.5	-1.4	-1.9
Reaction time num false alarms	2.4	3.3	4.7	1.9	1.6	2.0	-1.3	-2.2
Reaction time num false alarms AUC	2.4	3.3	4.4	1.8	1.6	2.0	-1.4	-2.1
Reaction time trials correct on left	0.2	0.3	0.5	-0.7	-0.7	-0.4	0.7	0.4
Reaction time trials on left	0.2	0.2	0.3	-0.6	-0.6	-0.3	0.6	0.3
Reaction time mean	0.2	0.3	0.4	0.6	0.6	0.5	-0.6	-0.6
Reaction time mean AUC	0.2	0.3	0.3	0.5	0.5	0.4	-0.6	-0.5
Median of all reaction times	0.0	0.0	0.1	-0.1	-0.0	-0.2	-0.1	0.1
Reaction time omissions	1.5	2.0	3.4	1.3	1.1	1.8	-0.9	-1.9
Reaction time false alarm rate	2.7	3.7	4.1	2.0	1.9	2.0	-1.7	-2.0
Reaction time premature initiation rate	0.1	0.1	0.3	-0.2	-0.4	-0.0	0.5	0.3
Reaction time premature initiations	0.4	0.5	0.9	-0.7	-0.9	-0.4	1.0	0.5
Std. dev. reaction times	1.6	2.3	2.9	1.5	1.5	1.5	-1.3	-1.7
Reaction time trials completed	0.2	0.2	0.3	-0.6	-0.6	-0.3	0.6	0.3
Reaction time trials AUC	0.1	0.2	0.2	-0.5	-0.5	-0.3	0.4	0.2
Run reversals in cocaine runway, females	1.2	1.1	1.2	-1.0	-1.1	-1.1	1.1	1.1
Run reversals in cocaine runway, males	0.8	0.8	1.4	-1.2	-0.8	-0.9	0.6	0.7
Latency to leave start box in cocaine runway	1.1	1.2	3.1	-0.5	-1.3	-0.7	1.8	0.5
Latency to leave start box in cocaine runway, F	0.2	0.2	0.7	0.1	-0.5	-0.1	0.8	-0.3
Latency to leave start box in cocaine runway, M	2.7	2.6	4.4	-1.3	-1.8	-1.4	2.1	1.3
Std. dev. time between licks in bursts	0.1	0.1	0.2	0.4	0.2	0.5	-0.1	-0.4
Total sessions with >9 infusions	2.3	2.6	3.6	-1.9	-1.3	-1.9	0.8	1.8
Short access day 1 total inactive lever presses	1.6	1.8	2.4	-1.6	-1.3	-1.5	1.2	1.1
Short access day 10 total inactive lever presses	0.5	0.6	1.5	0.5	0.1	1.1	0.2	-1.2
Short access day 1 total infusions	1.7	1.8	3.0	-1.4	-1.2	-1.7	1.1	1.3
Short access day 10 total infusions	2.6	2.9	3.6	-1.9	-1.6	-1.9	1.4	1.7
Short access total infusions	1.7	1.9	2.6	-1.5	-1.3	-1.6	1.1	1.3
Short access day 1 locomotion	1.6	1.7	2.2	-1.5	-1.2	-1.5	0.9	1.4
Short access day 10 total locomotion	1.1	1.3	1.6	-1.3	-1.0	-1.3	0.8	1.2
Short access total locomotion	1.9	2.0	2.7	-1.6	-1.2	-1.6	0.8	1.6
One hour access (0.3 mA shock)	5.5	6.4	7.1	-2.4	-2.5	-2.7	2.4	2.6
Compulsive drug intake	0.2	0.2	0.5	0.7	0.3	0.6	-0.1	-0.5
One hour access (shock baseline)	3.8	4.4	5.6	-2.2	-1.9	-2.4	1.7	2.2
Social response proportion	0.1	0.1	0.3	-0.0	0.2	-0.2	-0.3	0.6
Social responses	0.3	0.4	0.5	0.7	0.6	0.6	-0.5	-0.7
Social time	0.1	0.1	0.5	0.1	0.5	-0.2	-0.7	0.2
Soleus weight	3.5	10.4	12.0	-3.5	-3.5	-3.0	3.4	2.7
Bone: stiffness	0.2	0.2	0.4	0.4	0.5	0.7	-0.5	-0.2
Tibialis anterior weight	0.9	3.0	3.6	-1.9	-1.9	-1.7	1.8	1.3
Time to tail flick, vehicle, before self-admin	2.7	2.8	3.3	1.5	1.7	1.6	-1.8	-1.8
Time to tail flick, vehicle, after self-admin	8.3	8.9	11.0	3.1	2.8	3.1	-2.6	-3.3
Time to tail flick, test, before self-admin	1.0	1.0	1.5	-1.2	-0.9	-1.0	0.6	1.2
Time to tail flick, test, after self-admin	0.6	0.6	0.9	-1.0	-0.7	-0.7	0.5	1.0
Delta time to tail flick, vehicle, before/after SA	0.9	0.9	1.3	1.1	0.7	1.1	-0.5	-1.2
Delta time to tail flick, test, before/after SA	2.0	1.8	2.2	-1.3	-1.3	-1.4	1.3	1.5
Tibia length	1.1	3.2	4.1	1.7	2.0	1.2	-2.0	-1.9
Ambulatory time before self-admin	0.1	0.1	0.2	0.2	0.4	-0.0	-0.4	-0.3
Ambulatory time after self-admin	0.1	0.1	0.2	-0.2	-0.2	-0.5	0.3	-0.0
Bone: tissue strength	0.7	0.7	1.2	0.7	1.0	0.5	-1.1	-0.7
Total heroin consumption	4.4	5.2	5.9	-2.1	-2.2	-2.4	2.2	2.4
Bone: trabecular number	4.0	6.2	8.5	-2.5	-2.8	-2.2	2.9	1.8
Bone: trabecular spacing	1.1	1.4	2.9	1.1	1.5	0.6	-1.7	-0.6
Bone: trabecular thickness	0.5	0.6	1.5	-0.5	-1.0	-0.3	1.2	0.0
Bone: trabecular tissue density	0.1	0.1	0.2	-0.1	-0.3	-0.1	0.4	0.4
Water consumed over 24 hours	0.4	0.5	1.1	-0.6	-0.9	-0.3	1.0	0.3
Number of responses in last shaping day	1.7	1.7	2.2	-1.3	-1.3	-1.5	1.2	1.2