Itsn2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Eye	alternative polyA	XM_063261879.1	0.26	0.16	7.5e-03	0.1	0.05	0.05	0.07	1.4e-02	6.2e-02	6.4e-02	2.8e-02
2	Eye	isoform ratio	XM_063261879.1	0.36	0.17	5.8e-03	0.08	0.06	0.05	0.06	2.1e-02	3.8e-02	6.4e-02	3.8e-02
3	Adipose	gene expression	Itsn2	0.02	0.02	7.8e-03	0	0	-0	-0	3.6e-01	1.3e-01	5.8e-01	4.3e-01
4	PL	intron excision ratio	chr6_33336657_33357620	0.02	0.02	6.3e-03	0.02	0.01	0.01	0.01	5.0e-03	8.5e-03	1.4e-02	7.4e-03
5	Brain	gene expression	Itsn2	0.03	0.03	8.7e-03	0.02	0.01	0	0.01	2.9e-03	1.5e-02	1.8e-01	2.0e-02
6	PL	gene expression	Itsn2	0.02	0.01	4.9e-03	0.02	0.01	0.01	0.01	3.9e-03	7.3e-03	7.5e-03	1.1e-02
7	Brain	mRNA stability	Itsn2	0.02	0.02	9.4e-03	0	0.01	0.01	0.01	1.3e-01	1.3e-02	6.3e-02	3.3e-02
8	Eye	intron excision ratio	chr6_33409270_33411703	2.7	0.01	8.3e-03	-0.01	-0.02	NA	NA	5.1e-01	8.7e-01	NA	NA
9	Eye	intron excision ratio	chr6_33336657_33357620	5.3	1.6	2.6e-03	-0.02	-0.01	-0.02	NA	9.7e-01	5.9e-01	8.9e-01	NA

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9
Bone: apparent density	2.1	3.9	6.8	-1.9	-1.9	-2.4	-1.8	1.8	1.8	2.6	2.2	-0.6
Area under the delay curve	0.0	0.1	0.1	-0.3	-0.3	0.1	0.2	0.3	0.3	-0.1	-0.3	0.1
BMI with tail	2.4	8.5	13.1	3.3	3.3	3.1	3.6	-3.0	-3.1	-2.8	-0.7	-2.1
BMI without tail	1.2	6.6	9.1	3.0	3.0	2.5	2.9	-2.8	-2.8	-2.1	0.3	-2.6
Body weight	2.6	11.5	15.2	3.9	3.9	3.8	3.6	-3.7	-3.7	-3.5	-2.1	-1.4
Weight adjusted by age	0.3	0.8	2.3	1.0	1.0	0.7	1.0	-0.7	-0.7	-0.7	-0.0	-1.5
Bone surface	0.4	0.8	1.4	-0.8	-0.8	-1.1	-0.6	1.1	1.0	1.2	0.9	-0.6
Bone volume	1.0	2.1	3.4	-1.3	-1.3	-1.8	-1.2	1.6	1.6	1.8	1.4	-0.5
Breakpoint value in progressive ratio session	0.6	1.1	1.9	-0.8	-0.8	-1.2	-1.2	1.4	1.4	1.2	1.0	-0.3
Number of licking bursts	0.7	2.2	3.5	1.3	1.3	1.8	1.9	-1.6	-1.7	-1.7	-1.1	-0.2
Context. condit. distance diff. score	0.7	0.8	2.9	-0.4	-0.4	-0.9	-0.2	0.6	0.5	1.1	1.7	-1.2
Locomotion velocity, session 1	0.1	0.1	0.3	0.1	0.1	0.3	0.5	-0.2	-0.2	-0.3	0.2	-0.1
Locomotion distance, session 1	0.7	0.9	1.9	-1.4	-1.4	-0.9	-0.7	0.9	0.9	0.8	0.8	0.4
Locomotion velocity, session 2	0.4	0.4	1.5	0.6	0.6	0.7	1.2	-0.3	-0.3	-0.6	0.2	-0.8
Locomotion distance, session 2	0.1	0.1	0.3	-0.5	-0.5	0.1	0.2	0.3	0.2	-0.2	-0.3	0.2
Locomotion velocity, session 3	0.1	0.1	0.7	-0.0	-0.0	-0.0	0.0	-0.2	-0.2	0.1	0.9	-0.5
Locomotion distance, session 3	0.1	0.2	1.0	0.0	0.0	-0.1	0.0	-0.1	-0.1	0.2	1.0	-0.6
Stereotopy head waving bouts, day 3	2.8	3.4	4.7	-1.7	-1.7	-2.1	-2.1	1.8	1.8	2.2	2.1	-0.3
Stereotopy head waving duration, day 3	0.4	0.4	0.8	-0.6	-0.6	-0.8	-0.9	0.6	0.6	0.8	0.7	-0.0
Locomotion velocity, session 7	0.1	0.1	0.3	-0.1	-0.1	0.1	0.3	-0.0	-0.1	0.0	0.3	-0.6
Locomotion distance, session 7	0.5	0.7	1.3	0.9	0.9	0.8	0.8	-0.8	-0.9	-0.7	0.3	-1.2
Stereotopy head waving bouts, day 7	0.1	0.1	0.6	-0.2	-0.2	0.2	0.2	-0.4	-0.4	-0.2	-0.3	0.8
Stereotopy head waving duration, day 7	0.2	0.2	0.9	-0.6	-0.6	-0.2	-0.4	-0.0	0.0	0.2	-0.2	0.9
Locomotion velocity, session 8	1.0	1.2	3.2	-0.6	-0.6	-1.1	-0.5	1.1	1.1	1.2	1.8	-1.1
Locomotion distance, session 8	1.3	1.9	3.2	-1.4	-1.4	-1.5	-0.9	1.4	1.3	1.6	1.8	-0.7
Degree of sensitization distance	0.9	1.0	1.4	1.1	1.1	1.2	1.0	-1.1	-1.1	-1.1	-0.6	-0.5
Degree of sensitization stereotypy	1.0	1.1	2.1	0.4	0.4	1.2	1.0	-1.1	-1.1	-1.3	-1.5	1.2
Conditioned locomotion	1.9	2.2	3.7	-1.4	-1.4	-1.7	-1.3	1.2	1.2	1.9	1.9	-0.7
Cocaine response after cond. corrected	0.2	0.3	1.4	-0.3	-0.3	0.2	-0.1	0.0	0.0	-0.3	-1.2	1.2
Cocaine response after cond. not corrected	0.5	0.7	2.7	-0.8	-0.8	-0.3	-0.8	0.5	0.5	0.1	-1.1	1.6
Cocaine response before conditioning	1.5	1.8	2.7	-1.5	-1.5	-1.5	-1.6	1.4	1.5	1.4	0.8	0.6
Saline control response	0.9	1.2	1.9	-1.2	-1.2	-1.2	-1.4	1.2	1.2	1.2	0.4	0.5
Bone: connectivity density	1.1	1.8	3.2	-1.4	-1.4	-1.7	-1.2	1.3	1.3	1.8	1.2	-0.4
Bone: cortical apparent density	0.2	0.3	0.7	-0.3	-0.3	-0.4	-0.6	0.7	0.7	0.2	-0.4	0.9
Bone: cortical area	0.1	0.2	0.7	0.2	0.2	0.4	0.2	-0.4	-0.4	-0.5	-0.8	0.6
Bone: cortical porosity	1.3	1.4	2.2	-1.3	-1.3	-1.2	-1.5	1.3	1.3	1.1	0.1	0.9
Bone: cortical porosity	1.2	1.3	1.8	-1.2	-1.2	-1.3	-1.3	1.4	1.3	1.3	0.7	0.2
Bone: cortical thickness	0.7	1.2	4.6	0.5	0.5	0.9	0.3	-0.6	-0.6	-1.2	-2.1	1.6
Bone: cortical thickness	0.3	0.4	0.6	-0.7	-0.7	-0.6	-0.8	0.7	0.7	0.4	-0.1	0.6
Bone: cortical tissue density	0.1	0.2	0.5	-0.2	-0.2	-0.3	-0.4	0.6	0.6	0.1	-0.4	0.7
Condit. Reinf. active minus inactive responses	2.8	3.2	4.9	1.6	1.6	2.1	1.7	-1.8	-1.8	-2.2	-2.2	0.4
Condit. Reinf. active-inactive response ratio	2.1	2.3	3.2	1.6	1.6	1.7	1.2	-1.6	-1.6	-1.7	-1.8	0.1
Condit. Reinf. active responses	0.3	0.4	0.8	0.3	0.3	0.8	0.7	-0.6	-0.6	-0.9	-0.9	0.2
Condit. Reinf. inactive responses	1.1	1.4	2.1	-1.4	-1.4	-1.3	-1.0	1.3	1.2	1.3	1.2	-0.1
Incentive salience index mean	0.9	1.2	2.1	0.7	0.7	1.3	1.2	-1.1	-1.1	-1.4	-1.5	0.4
Condit. Reinf. lever presses	0.3	0.4	1.2	-1.1	-1.1	-0.3	-0.2	0.5	0.5	0.2	-0.2	0.7
Condit. Reinf. active minus inactive responses	0.3	0.5	1.4	-0.7	-0.7	-0.7	-1.2	0.6	0.6	0.6	-0.1	0.8
Condit. Reinf. active-inactive response ratio	0.1	0.2	0.8	-0.4	-0.4	-0.1	-0.3	0.1	0.1	0.0	-0.6	0.9
Condit. Reinf. active responses	0.4	0.5	1.8	-0.7	-0.7	-0.3	-1.0	0.3	0.3	0.1	-0.8	1.4
Condit. Reinf. inactive responses	0.1	0.1	0.4	-0.5	-0.5	-0.1	-0.5	0.1	0.1	0.0	-0.2	0.6
Condit. Reinf. lever presses	0.7	1.0	2.6	-1.2	-1.2	-0.7	-1.3	0.9	0.9	0.5	-0.4	1.6
Condit. Reinf. lever reinforcers received	0.4	0.5	2.0	-0.6	-0.6	-0.2	-0.9	0.3	0.3	-0.0	-1.0	1.4
Conditioned reinforcement - actives	1.1	4.4	7.0	-2.4	-2.4	-2.4	-2.6	2.1	1.8	2.2	0.4	1.7
Conditioned reinforcement - inactives	2.3	6.3	9.5	-3.1	-3.1	-2.7	-2.8	2.5	2.3	2.5	0.7	2.1
Conditioned locomotion	2.2	3.3	5.7	-1.8	-1.8	-1.9	-2.4	2.4	2.2	1.7	-0.2	0.8
Patch foraging indifference point 0 sec	0.1	0.2	0.7	0.2	0.2	-0.1	0.4	-0.2	-0.2	0.3	0.7	-0.9
Patch foraging indifference point AUC	0.1	0.3	1.3	-0.3	-0.3	-0.2	0.1	-0.3	-0.3	0.4	1.2	-0.9
Delay disc. indifference point, 0s delay	0.5	0.5	1.5	0.3	0.3	0.6	0.4	-0.3	-0.3	-0.9	-1.2	1.2
Delay disc. indifference point, 16s delay	0.0	0.0	0.1	-0.0	-0.0	0.0	0.1	0.3	0.2	-0.1	-0.0	-0.3
Delay disc. indifference point, 2s delay	0.2	0.2	0.8	0.0	0.0	0.2	-0.1	0.2	0.3	-0.4	-0.9	0.8
Delay disc. indifference point, 24s delay	1.5	2.4	3.3	-1.8	-1.8	-1.7	-1.6	1.7	1.6	1.7	1.1	-0.3
Delay disc. indifference point, 4s delay	0.1	0.1	0.2	0.0	0.0	0.1	0.2	0.3	0.5	-0.2	-0.4	0.1
Delay disc. indifference point, 8s delay	0.1	0.1	0.3	-0.3	-0.3	-0.2	0.1	0.5	0.4	0.2	0.3	-0.6
Indifference point function ln k	0.7	2.0	2.9	-1.7	-1.7	-1.4	-1.5	1.5	1.5	1.1	-0.1	1.4
Indifference point function log k	0.7	2.0	2.9	-1.7	-1.7	-1.4	-1.5	1.5	1.5	1.1	-0.1	1.4
Patch foraging total patch changes 0 sec	0.1	0.2	0.7	0.2	0.2	-0.1	0.4	-0.2	-0.2	0.3	0.7	-0.9
Patch foraging total patch changes 12 sec	1.4	1.9	3.1	1.4	1.4	1.4	1.5	-1.8	-1.8	-1.2	-0.1	-1.0
Patch foraging total patch changes 18 sec	0.4	1.0	3.3	0.8	0.8	0.2	0.7	-0.7	-0.7	0.2	1.7	-1.8
Patch foraging total patch changes 24 sec	0.3	1.0	1.7	1.0	1.0	1.0	1.3	-1.2	-1.2	-0.9	-0.4	-0.6
Patch foraging total patch changes 6 sec	0.8	1.3	2.0	1.1	1.1	1.1	1.4	-1.4	-1.4	-0.9	0.1	-1.1
Patch foraging time to switch 0 sec	0.3	1.0	2.4	1.6	1.6	0.9	0.6	-0.9	-0.8	-0.9	-0.4	-0.5
Patch foraging water rate 0 sec	1.2	4.3	6.6	-2.6	-2.6	-2.3	-1.9	2.3	2.3	2.2	1.0	0.5
Patch foraging water rate 12 sec	0.1	0.5	2.6	-0.1	-0.1	0.4	-0.0	-0.1	-0.1	-0.6	-1.6	1.2
Patch foraging water rate 18 sec	1.6	3.5	5.2	-2.3	-2.3	-1.7	-1.9	1.9	1.9	1.3	-0.8	2.3
Patch foraging water rate 24 sec	0.1	0.1	0.2	0.4	0.4	0.2	0.4	-0.1	-0.1	-0.1	-0.2	-0.5
Patch foraging water rate 6 sec	1.0	1.5	2.3	-1.4	-1.4	-1.0	-1.3	1.3	1.3	0.8	-0.7	1.5
Seeking ratio, delayed vs. immediate footshock	0.3	0.5	0.7	0.9	0.9	0.8	0.6	-0.8	-0.8	-0.7	-0.1	0.3
Distance traveled before self-admin	0.1	0.1	0.5	-0.1	-0.1	-0.0	-0.5	0.7	0.4	0.1	0.5	0.0
Distance traveled after self-admin	0.1	0.2	0.7	0.7	0.7	0.1	-0.1	0.1	-0.1	-0.0	0.8	-0.6
Extensor digitorum longus weight	1.5	5.9	9.0	-3.0	-3.0	-2.6	-2.7	2.5	2.5	2.5	1.3	1.0
Bone: elastic displacement	1.3	1.7	3.0	-1.4	-1.4	-1.5	-1.7	1.3	1.3	1.4	0.6	0.8
Bone: elastic work	1.0	1.3	2.0	-1.1	-1.1	-1.3	-1.4	1.2	1.2	1.2	0.4	0.8
Bone: endosteal estimation	0.4	1.0	2.9	-0.8	-0.8	-0.9	-0.5	0.7	0.6	1.1	1.7	-1.0
Bone: endosteal perimeter	0.2	0.4	2.0	0.0	0.0	-0.1	0.4	-0.3	-0.3	0.3	1.4	-1.1
Epididymis fat weight	11.2	56.7	79.5	8.9	8.9	8.2	8.4	-8.0	-8.0	-7.7	-3.6	-3.6
Delta time in closed arm before/after self-admin	0.2	0.2	0.7	0.2	0.2	-0.3	-0.1	0.1	0.1	0.3	0.9	-0.8
Delta time in open arm before/after self-admin	0.4	0.5	1.3	0.1	0.1	0.9	1.0	-1.1	-1.1	-0.8	-0.1	-0.1
Diff in mean of infusions in LGA sessions	0.3	0.5	1.1	0.5	0.5	0.7	1.0	-0.6	-0.6	-0.6	0.2	-0.9
Delay discount exponential model param	0.1	0.2	0.4	0.5	0.5	0.3	0.1	-0.6	-0.7	-0.3	-0.0	0.1
Extinction: sum of active levers before priming	0.3	0.4	1.7	0.2	0.2	-0.5	0.2	0.2	0.4	0.6	1.2	-1.3
Active lever presses in extinction session 6	0.3	0.3	0.9	-0.7	-0.7	-0.5	-0.5	0.2	0.1	0.6	1.0	-0.2
Bone: final force	0.2	0.3	0.7	0.3	0.3	0.7	0.5	-0.6	-0.6	-0.7	-0.8	0.5
Bone: final moment	0.1	0.2	0.4	0.2	0.2	0.5	0.3	-0.5	-0.5	-0.5	-0.6	0.5
Food consumed during 24 hour testing period	0.0	0.1	0.3	-0.5	-0.5	-0.1	-0.1	0.2	0.2	0.1	0.3	0.2
Glucose	0.7	1.1	1.8	1.3	1.3	1.0	0.9	-1.3	-1.3	-0.9	-0.4	-0.6
Heart weight	0.6	0.9	1.3	1.1	1.1	1.1	1.0	-0.9	-1.0	-1.0	-0.4	-0.5
Delay discount hyperbolic model param	0.1	0.1	0.3	0.3	0.3	0.1	-0.1	-0.5	-0.5	-0.0	0.1	0.1
Intermittent access intake day 1-15 change	0.6	3.4	6.2	-1.7	-1.7	-2.1	-2.5	1.9	2.2	1.9	0.4	1.6
Intermittent access intake escalation	0.5	2.8	5.3	-1.5	-1.5	-1.8	-2.3	1.7	2.0	1.7	0.2	1.5
Intermittent access intake escalation 2	1.1	1.9	3.5	-1.1	-1.1	-1.6	-1.9	1.4	1.8	1.5	0.5	1.0
Intermitt. access day 1 inactive lever presses	0.0	0.4	1.2	-1.1	-1.1	-0.4	-0.4	0.4	0.1	0.4	-0.1	0.7
Intermitt. access day 15 inactive lever presses	0.1	0.7	1.2	-0.9	-0.9	-0.9	-0.6	0.6	0.8	0.9	1.1	0.1
Intermitt. access escalation Index	0.8	2.5	5.0	2.2	2.2	1.4	1.2	-1.6	-1.7	-1.1	0.1	-1.5
Intermittent access day 1 total infusions	0.3	0.8	2.5	-1.6	-1.6	-0.8	-0.6	0.9	0.2	0.6	-0.1	0.6
Intermittent access day 15 total infusions	1.2	2.9	4.5	-2.1	-2.1	-1.7	-2.0	1.7	1.4	1.4	-0.4	1.8
Intermittent access terminal intake (last 3 days)	2.4	4.2	6.6	-2.6	-2.6	-1.9	-2.3	2.0	1.7	1.4	-0.8	2.5
Intermittent access total infusions	2.1	2.5	4.4	-2.1	-2.1	-1.5	-1.7	1.7	1.2	1.1	-0.6	1.5
Intermittent access day 1 locomotion	1.2	2.1	3.8	-2.0	-2.0	-1.0	-1.3	1.5	1.1	0.6	-1.2	1.9
Intermittent access day 15 total locomotion	0.2	0.9	2.6	-1.1	-1.1	-0.3	-0.8	0.7	0.6	0.0	-1.3	1.6
Intermittent access total locomotion	1.9	2.2	3.7	-1.7	-1.7	-1.0	-1.4	1.6	1.3	0.5	-1.7	1.9
Intermittent access standard deviation	0.4	2.2	3.6	-1.9	-1.9	-1.5	-1.6	1.5	1.5	1.3	0.5	1.1
Left kidney weight	0.0	0.1	0.2	-0.2	-0.2	0.4	0.4	-0.4	-0.5	-0.4	-0.2	-0.2
Right kidney weight	0.3	2.1	3.0	1.3	1.3	1.7	1.7	-1.6	-1.7	-1.6	-0.8	-0.8
Cocaine induced anxiety	0.3	0.7	2.1	-0.4	-0.4	-1.1	-0.7	0.5	0.4	1.2	1.5	-0.6
Post-drug Anxiety	1.0	1.1	2.0	1.0	1.0	0.8	1.3	-1.2	-1.4	-0.5	0.7	-1.2
Baseline Anxiety	1.9	3.2	4.9	1.8	1.8	2.2	2.2	-1.9	-1.9	-2.1	-1.2	-0.5
Tail length	0.1	0.5	1.5	-0.7	-0.7	-0.5	-1.2	0.2	0.3	0.4	-0.2	1.2
Length with tail	0.2	0.9	2.5	0.8	0.8	0.9	0.3	-0.9	-0.8	-1.0	-1.6	0.7
Length without tail	0.2	0.8	2.0	0.8	0.8	1.0	0.9	-0.8	-0.8	-1.1	-1.4	0.3
Times rat made contact with spout	1.1	1.2	2.0	-1.0	-1.0	-1.3	-0.8	1.1	1.1	1.4	1.3	-0.7
Lifetime Intake	2.3	2.8	4.8	-2.2	-2.2	-1.5	-1.9	1.8	1.3	1.1	-0.8	1.7
Liver weight, left	2.5	4.3	8.4	1.8	1.8	2.2	1.7	-1.9	-1.8	-2.5	-2.9	1.8
Liver weight, right	3.1	5.3	7.1	2.5	2.5	2.7	2.5	-2.5	-2.5	-2.6	-1.6	-0.4
Locomotor activity	2.3	3.7	6.3	1.6	1.6	2.2	2.1	-2.5	-2.5	-2.1	-1.1	-0.0
Locomotor testing distance	0.9	2.2	4.4	1.2	1.2	1.7	1.7	-2.1	-2.1	-1.5	-0.3	-0.4
Locomotor testing rearing	0.1	0.2	0.3	0.2	0.2	0.5	0.4	-0.6	-0.6	-0.5	-0.3	0.2
Locomotion in novel chamber	1.7	2.3	3.7	1.2	1.2	1.7	1.6	-1.4	-1.6	-1.9	-1.9	0.5
Locomotion in novel chamber post-restriction	0.3	1.0	2.1	1.4	1.4	1.1	0.8	-0.7	-0.7	-1.2	-0.9	-0.2
Fecal boli incidents, locomotor time 1	1.0	2.7	4.7	-2.2	-2.2	-1.9	-1.8	1.2	1.3	1.8	0.8	0.9
Change in fecal boli incidents, locomotor task	2.0	2.2	6.1	2.5	2.5	1.3	1.1	-0.9	-1.0	-1.3	-0.7	-0.7
Time >=10cm from walls, locomotor time 1	0.4	0.5	0.9	-0.4	-0.4	-0.7	-0.6	0.9	0.9	0.8	1.0	-0.4
Bouts of movement, locomotor time 1	0.2	0.3	0.6	-0.8	-0.8	-0.5	-0.2	0.3	0.2	0.5	0.5	0.3
Total resting periods, locomotor time 1	0.4	0.4	0.8	-0.8	-0.8	-0.7	-0.4	0.5	0.4	0.8	0.9	-0.1
Rest time, locomotor task time 1	0.1	0.1	0.2	-0.1	-0.1	-0.4	-0.4	0.0	0.1	0.5	0.5	-0.3
Distance moved, locomotor task time 1	0.2	0.6	1.2	0.6	0.6	1.0	1.0	-0.7	-0.7	-1.1	-0.8	-0.2
Vertical activity count, locomotor time 1	0.0	0.3	1.1	0.1	0.1	0.5	0.3	-0.0	-0.2	-0.6	-1.1	0.8
Time >=10cm from walls, locomotor time 2	0.6	1.8	2.9	-0.8	-0.8	-1.6	-1.4	1.6	1.5	1.7	1.5	0.1
Bouts of movement, locomotor time 2	0.0	0.0	0.1	-0.1	-0.1	-0.0	0.1	0.4	0.2	-0.0	0.1	0.0
Total resting periods, locomotor time 2	0.0	0.0	0.1	-0.0	-0.0	-0.0	0.2	0.2	0.1	0.0	0.3	-0.1
Rest time, locomotor task time 2	0.0	0.0	0.1	0.0	0.0	-0.1	0.2	-0.3	-0.1	0.2	0.3	-0.3
Distance moved, locomotor task time 2	0.2	0.2	1.0	0.1	0.1	0.2	-0.2	0.4	0.3	-0.4	-1.0	0.8
Vertical activity count, locomotor time 2	0.1	0.2	0.5	-0.0	-0.0	-0.5	-0.7	0.6	0.5	0.3	-0.2	0.7
Light reinforcement 1	0.2	0.8	1.9	-1.2	-1.2	-0.6	-1.2	0.4	0.5	0.5	-0.0	1.4
Light reinforcement 2	1.2	2.7	4.2	-1.7	-1.7	-1.8	-2.1	1.9	1.9	1.6	0.5	1.0
Bone: marrow area	0.4	0.9	2.7	-0.8	-0.8	-0.9	-0.4	0.7	0.6	1.1	1.7	-1.0
Bone: maximum diameter	0.1	0.1	0.6	-0.3	-0.3	-0.3	-0.1	0.1	0.1	0.4	0.8	-0.4
Bone: maximum force	0.0	0.1	0.2	-0.1	-0.1	0.2	0.1	-0.1	-0.2	-0.3	-0.5	0.5
Bone: maximum moment	0.0	0.0	0.2	-0.2	-0.2	0.0	-0.1	-0.0	-0.0	-0.1	-0.3	0.5
Mean time between licks in bursts	0.1	0.9	1.7	0.9	0.9	0.9	1.3	-0.9	-1.0	-0.7	0.7	-1.1
Mean num. licks in bursts	1.4	3.7	5.7	-1.7	-1.7	-2.3	-2.2	2.1	2.1	2.4	1.7	-0.3
Cd content in liver	0.3	0.3	0.8	0.6	0.6	0.3	0.5	-0.5	-0.5	-0.1	0.6	-0.9
Co content in liver	1.7	2.0	3.1	-1.8	-1.8	-1.4	-1.5	1.5	1.5	1.2	0.2	1.2
Cu content in liver	0.2	0.2	0.6	0.5	0.5	0.3	0.6	-0.3	-0.4	-0.2	0.4	-0.7
Fe content in liver	1.8	2.2	3.5	-1.4	-1.4	-1.8	-1.3	1.5	1.5	1.9	1.6	-0.7
K content in liver	1.1	1.1	1.8	1.2	1.2	1.1	1.0	-1.3	-1.3	-1.0	-0.4	-0.2
Mg content in liver	0.0	0.1	0.1	0.4	0.4	0.1	0.0	-0.3	-0.3	-0.1	-0.1	-0.1
Mn content in liver	0.5	0.5	1.2	1.1	1.1	0.7	0.6	-0.4	-0.4	-0.7	-0.7	-0.1
Na content in liver	1.9	2.2	3.3	-1.8	-1.8	-1.5	-1.8	1.2	1.3	1.3	0.1	1.6
Rb content in liver	0.7	0.9	2.9	0.9	0.9	0.1	0.6	-0.5	-0.5	0.2	1.5	-1.7
Se content in liver	0.3	0.4	0.7	0.9	0.9	0.6	0.5	-0.5	-0.5	-0.7	-0.4	0.2
Sr content in liver	0.7	0.6	0.9	-0.4	-0.4	-0.9	-0.5	0.9	0.9	1.0	1.0	-0.6
Zn content in liver	1.7	2.0	2.7	1.5	1.5	1.6	1.5	-1.6	-1.6	-1.5	-1.0	-0.2
Bone: minimum diameter	1.0	1.9	3.0	1.4	1.4	1.6	1.7	-1.4	-1.4	-1.6	-0.9	-0.3
Time in familiar zone, hab. session 1	1.2	1.3	2.0	1.3	1.3	1.3	1.4	-1.0	-1.0	-1.3	-0.9	-0.5
Time in novel zone, hab. session 1	0.3	0.3	0.9	0.6	0.6	0.2	0.5	-0.4	-0.4	-0.0	0.7	-0.9
Total zone transitions, hab. session 1	0.4	0.6	1.6	-1.3	-1.3	-0.7	-0.6	0.6	0.5	0.7	0.4	0.2
Total locomotion distance, hab. session 1	0.9	1.3	2.9	-1.7	-1.7	-1.1	-1.1	1.0	1.0	0.9	0.3	1.1
Locomotion velocity, hab. session 1	1.8	2.6	5.3	-2.3	-2.3	-1.5	-1.6	1.4	1.4	1.3	0.1	1.7
Time in familiar zone, hab. session 2	0.0	0.1	0.2	0.2	0.2	0.1	0.2	0.1	0.1	-0.1	-0.2	-0.5
Time in novel zone, hab. session 2	0.3	0.3	0.5	0.7	0.7	0.5	0.7	-0.5	-0.5	-0.4	0.2	-0.7
Total zone transitions, hab. session 2	0.3	0.4	1.1	-0.7	-0.7	-0.5	0.0	0.4	0.3	0.7	1.0	-0.9
Total locomotion distance, hab. session 2	0.3	0.5	2.0	-0.4	-0.4	-0.4	0.1	0.1	0.1	0.6	1.4	-1.1
Locomotion velocity, hab. session 2	0.4	0.5	2.0	-0.6	-0.6	-0.5	0.0	0.1	0.1	0.7	1.4	-0.9
Novel to familiar place preference ratio	0.0	0.0	0.1	0.1	0.1	0.1	0.2	-0.3	-0.3	-0.1	-0.1	0.3
Novelty place preference	0.2	0.2	0.4	0.4	0.4	0.5	0.5	-0.6	-0.6	-0.5	-0.4	0.4
Time in novel zone, NPP test	0.2	0.2	0.5	0.5	0.5	0.5	0.7	-0.6	-0.6	-0.5	-0.2	-0.0
Total zone transitions, NPP test	0.9	1.3	2.9	-1.5	-1.5	-1.1	-0.6	0.8	0.7	1.2	1.7	-0.8
Total locomotion distance, NPP test	1.5	2.1	3.4	-1.7	-1.7	-1.5	-1.1	1.3	1.2	1.6	1.8	-0.6
Locomotion velocity, NPP test	1.7	2.5	3.9	-2.0	-2.0	-1.7	-1.5	1.2	1.2	1.8	1.7	0.2
Intraocular pressure	2.0	3.3	6.2	2.5	2.5	1.8	1.9	-1.7	-1.6	-1.7	-0.7	-1.2
Delta distance traveled before/after self-admin	0.9	1.0	2.0	1.1	1.1	0.9	1.1	-1.4	-1.3	-0.9	-0.2	-0.3
Delta ambulatory time before/after self-admin	0.0	0.0	0.1	0.2	0.2	-0.3	-0.0	-0.3	-0.2	0.3	0.3	-0.3
Parametrial fat weight	24.1	56.7	77.9	8.0	8.0	8.6	7.5	-8.8	-8.7	-8.3	-5.2	-0.9
Pavlov. Cond. lever latency	0.2	0.3	0.6	0.7	0.7	0.4	0.1	-0.4	-0.3	-0.5	-0.8	0.2
Pavlov. Cond. magazine entry latency	0.2	0.2	1.0	-0.0	-0.0	-0.1	0.5	0.0	-0.1	0.2	1.0	-1.0
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	-0.2	-0.2	-0.1	0.2	0.4	0.3	0.1	0.1	-0.1
Pavlov. Cond. index score	0.1	0.2	0.5	-0.3	-0.3	-0.2	0.4	0.2	0.2	0.3	0.7	-0.7
Pavlov. Cond. latency score	0.2	0.3	0.9	-0.3	-0.3	-0.2	0.4	0.3	0.2	0.4	0.9	-0.9
Pavlov. Cond. lever contacts	0.1	0.2	0.5	-0.7	-0.7	-0.3	0.1	0.3	0.3	0.2	0.4	0.1
Pavlov. Cond. magazine entry number	0.4	0.4	1.9	0.6	0.6	0.5	-0.2	-0.3	-0.2	-0.6	-1.4	0.9
Pavlov. Cond. intertrial magazine entries	0.5	0.6	1.3	-0.5	-0.5	-1.0	-1.1	0.9	0.9	1.0	0.1	0.3
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.6	-0.6	-0.6	-0.4	0.1	0.5	0.4	0.5	0.8	-0.4
Pavlov. Cond. response bias	0.6	0.7	1.7	-1.0	-1.0	-0.8	-0.3	0.6	0.6	0.9	1.3	-0.4
Pavlov. Cond. lever latency	0.6	0.8	1.0	1.0	1.0	1.0	0.9	-0.9	-0.9	-1.0	-0.8	0.1
Pavlov. Cond. magazine entry latency	0.1	0.1	0.5	0.1	0.1	-0.1	-0.1	-0.2	-0.1	0.3	0.7	-0.6
Pavlov. Cond. change in total contacts	0.0	0.1	0.4	-0.2	-0.2	-0.2	-0.3	0.2	0.1	0.3	0.6	-0.5
Pavlov. Cond. index score	0.3	0.5	0.7	-0.6	-0.6	-0.8	-0.8	0.6	0.6	0.8	0.8	-0.2
Pavlov. Cond. latency score	0.4	0.6	0.9	-0.7	-0.7	-0.9	-0.9	0.7	0.7	0.9	0.9	-0.3
Pavlov. Cond. lever contacts	0.2	0.3	0.4	-0.7	-0.7	-0.6	-0.6	0.5	0.5	0.6	0.5	-0.1
Pavlov. Cond. magazine entry number	0.2	0.3	1.2	-0.5	-0.5	-0.2	-0.2	0.5	0.5	0.0	-0.8	1.1
Pavlov. Cond. intertrial magazine entries	0.6	1.3	2.0	1.3	1.3	1.2	1.3	-0.8	-0.8	-1.3	-1.4	0.3
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.8	-0.4	-0.4	-0.6	-0.6	0.4	0.4	0.7	0.9	-0.4
Pavlov. Cond. response bias	0.4	0.6	0.9	-0.9	-0.9	-0.8	-0.7	0.6	0.6	0.9	0.9	-0.3
Time in closed arm before self-admin	0.1	0.1	0.3	0.2	0.2	0.4	0.4	-0.4	-0.6	-0.3	0.2	-0.5
Time in closed arm after self-admin	1.1	1.2	1.8	1.1	1.1	1.3	1.3	-1.1	-1.1	-1.3	-0.9	-0.2
Time in open arm before self-admin	0.1	0.1	0.2	0.2	0.2	0.1	-0.2	0.1	0.2	-0.2	-0.5	0.5
Time in open arm after self-admin	0.1	0.1	0.3	-0.6	-0.6	-0.2	-0.2	0.1	0.2	0.3	0.4	0.3
Bone: periosteal estimation	0.1	0.3	0.5	-0.7	-0.7	-0.6	-0.3	0.4	0.4	0.6	0.7	-0.2
Bone: periosteal perimeter	0.1	0.1	0.5	-0.0	-0.0	-0.0	0.2	-0.3	-0.3	0.2	0.7	-0.4
Bone: post-yield work	1.2	2.1	2.9	-1.4	-1.4	-1.6	-1.2	1.5	1.5	1.7	1.7	-0.6
Progressive ratio test 1 active lever presses	0.8	1.3	2.9	-1.7	-1.7	-0.7	-1.0	1.1	0.8	0.4	-1.0	1.3
Progressive ratio test 1 breakpoint	0.8	1.3	2.9	-1.7	-1.7	-0.8	-1.0	1.2	0.8	0.5	-0.9	1.1
Progressive ratio test 1 inactive lever presses	0.6	1.7	3.8	-1.9	-1.9	-1.2	-1.3	1.1	0.8	0.9	-0.2	1.2
Progressive ratio test 2 active lever presses	2.4	3.4	5.0	-2.2	-2.2	-1.7	-2.0	2.0	1.7	1.3	-0.6	2.0
Progressive ratio test 2 breakpoint	2.7	3.4	5.0	-2.2	-2.2	-1.7	-2.0	2.0	1.7	1.2	-0.8	2.2
Progressive ratio test 2 inactive lever presses	1.5	4.6	6.5	-2.6	-2.6	-2.2	-2.5	2.2	2.2	1.9	0.3	2.0
Incentive Sensitization - Responses	1.1	3.1	4.7	-1.8	-1.8	-1.7	-2.1	1.9	1.9	1.4	-0.3	2.2
Incentive Sensitization - Breakpoint	1.3	2.9	5.6	-1.7	-1.7	-1.6	-2.0	1.8	1.8	1.2	-0.5	2.4
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.5	0.1	0.1	0.0	0.4	-0.2	-0.1	0.1	0.7	-0.6
Progressive ratio	0.1	0.2	0.6	0.3	0.3	0.3	0.6	0.1	-0.3	-0.1	0.7	-0.8
Food seeking constrained by brief footshock	6.2	7.8	11.7	-3.4	-3.4	-3.1	-2.8	2.7	2.6	3.1	2.2	0.4
Seeking ratio, punishment vs. effort	0.9	1.9	3.2	-1.6	-1.6	-1.7	-1.8	1.1	1.4	1.6	0.7	0.5
Retroperitoneal fat weight	33.2	148.7	202.7	14.2	14.2	13.6	13.0	-13.1	-13.0	-13.0	-7.1	-4.0
Reaction time number correct	0.1	0.5	0.6	-0.8	-0.8	-0.8	-0.7	0.6	0.6	0.8	0.6	-0.0
Reaction time mean minus median	0.2	1.5	2.3	1.4	1.4	1.3	1.5	-1.3	-1.3	-1.3	-0.6	-0.4
Reaction time mean minus median AUC	0.2	1.4	2.3	1.1	1.1	1.4	1.5	-1.4	-1.4	-1.4	-0.8	-0.1
Reaction time num false alarms	1.5	2.6	4.1	1.6	1.6	1.7	1.9	-2.0	-2.0	-1.4	-0.2	-1.3
Reaction time num false alarms AUC	1.1	2.6	4.4	1.4	1.4	1.8	1.9	-2.1	-2.1	-1.5	-0.5	-0.9
Reaction time trials correct on left	0.1	0.5	0.6	-0.8	-0.8	-0.8	-0.7	0.6	0.6	0.8	0.6	-0.0
Reaction time trials on left	0.1	0.3	0.5	-0.7	-0.7	-0.7	-0.5	0.5	0.5	0.7	0.5	-0.0
Reaction time mean	0.1	0.3	0.4	0.6	0.6	0.6	0.6	-0.6	-0.6	-0.7	-0.3	0.0
Reaction time mean AUC	0.1	0.2	0.4	0.4	0.4	0.6	0.5	-0.5	-0.5	-0.6	-0.4	0.1
Median of all reaction times	0.0	0.0	0.0	0.0	0.0	0.1	0.0	-0.0	-0.0	-0.1	0.0	0.2
Reaction time omissions	1.4	2.3	4.9	1.1	1.1	1.8	2.2	-1.9	-2.0	-1.6	-0.4	-0.6
Reaction time false alarm rate	2.3	3.2	4.7	1.8	1.8	2.0	2.0	-2.2	-2.1	-1.8	-1.0	-0.6
Reaction time premature initiation rate	0.2	0.3	0.8	-0.3	-0.3	-0.4	-0.1	0.4	0.4	0.5	0.8	-0.9
Reaction time premature initiations	0.2	0.7	1.0	-0.8	-0.8	-0.9	-0.6	0.8	0.8	1.0	1.0	-0.7
Std. dev. reaction times	0.5	1.5	2.3	1.2	1.2	1.4	1.5	-1.4	-1.4	-1.3	-0.6	-0.5
Reaction time trials completed	0.1	0.3	0.5	-0.7	-0.7	-0.7	-0.5	0.5	0.5	0.7	0.5	-0.0
Reaction time trials AUC	0.1	0.3	0.4	-0.7	-0.7	-0.6	-0.5	0.5	0.5	0.6	0.3	0.1
Run reversals in cocaine runway, females	0.7	0.8	1.5	-0.8	-0.8	-1.2	-1.2	0.4	0.6	1.2	1.2	-0.1
Run reversals in cocaine runway, males	0.7	0.8	2.8	-1.2	-1.2	-0.6	-0.8	0.4	0.4	0.3	-0.4	1.7
Latency to leave start box in cocaine runway	1.6	2.2	6.3	-0.3	-0.3	-1.3	-0.9	1.1	0.9	1.8	2.5	-2.5
Latency to leave start box in cocaine runway, F	1.0	1.2	6.2	0.6	0.6	-0.4	-0.2	0.4	0.0	0.8	1.7	-2.5
Latency to leave start box in cocaine runway, M	1.8	1.7	3.5	-1.0	-1.0	-1.5	-1.1	1.1	1.2	1.7	1.9	-1.1
Std. dev. time between licks in bursts	0.2	0.3	1.0	0.3	0.3	0.4	0.8	-0.3	-0.4	-0.3	0.5	-1.0
Total sessions with >9 infusions	2.0	2.5	3.9	-2.0	-2.0	-1.3	-1.8	1.9	1.5	0.9	-1.2	1.5
Short access day 1 total inactive lever presses	2.3	4.7	8.2	-2.9	-2.9	-2.3	-2.4	2.1	1.8	2.0	0.1	1.7
Short access day 10 total inactive lever presses	0.1	1.0	4.9	-0.5	-0.5	-0.9	-0.1	-0.1	-0.4	1.2	2.2	-1.0
Short access day 1 total infusions	1.1	2.1	3.8	-1.8	-1.8	-1.4	-1.9	1.3	0.9	1.1	-0.6	1.5
Short access day 10 total infusions	1.2	2.0	3.5	-1.9	-1.9	-1.4	-1.7	1.4	1.0	1.2	-0.3	1.4
Short access total infusions	1.0	1.4	2.2	-1.5	-1.5	-1.0	-1.4	1.2	0.8	0.6	-1.0	1.3
Short access day 1 locomotion	0.6	1.1	2.0	-1.4	-1.4	-0.7	-0.9	1.1	0.6	0.4	-1.1	1.2
Short access day 10 total locomotion	0.4	1.6	2.6	-1.6	-1.6	-1.1	-1.4	1.5	1.4	0.9	-0.4	1.2
Short access total locomotion	1.4	2.2	3.4	-1.7	-1.7	-1.0	-1.3	1.8	1.6	0.5	-1.5	1.5
One hour access (0.3 mA shock)	4.3	5.1	8.2	-2.3	-2.3	-2.6	-2.9	2.6	2.4	2.4	0.7	1.1
Compulsive drug intake	0.2	0.2	0.7	0.8	0.8	0.2	0.2	-0.3	0.0	-0.0	0.4	-0.5
One hour access (shock baseline)	1.8	4.6	7.0	-2.6	-2.6	-2.3	-2.6	2.3	1.9	2.0	0.0	1.8
Social response proportion	0.2	0.3	0.9	0.9	0.9	0.1	-0.2	0.2	0.3	-0.2	-1.0	0.3
Social responses	0.3	0.4	1.0	1.0	1.0	0.6	0.5	-0.7	-0.6	-0.5	-0.1	-0.5
Social time	0.2	0.4	1.7	0.3	0.3	0.5	-0.2	-0.1	-0.1	-0.7	-1.3	0.9
Soleus weight	3.3	9.8	13.6	-3.7	-3.7	-3.5	-3.0	3.4	3.3	3.4	2.4	0.4
Bone: stiffness	0.1	0.2	0.5	0.0	0.0	0.5	0.4	-0.3	-0.3	-0.6	-0.7	0.5
Tibialis anterior weight	1.1	3.7	6.0	-2.5	-2.5	-2.0	-2.0	1.9	1.9	1.9	1.1	0.8
Time to tail flick, vehicle, before self-admin	0.5	0.6	1.4	0.2	0.2	0.9	0.9	-0.6	-0.8	-1.1	-1.2	0.5
Time to tail flick, vehicle, after self-admin	2.9	6.0	9.7	3.1	3.1	2.6	2.8	-2.2	-2.2	-2.4	-0.5	-2.1
Time to tail flick, test, before self-admin	0.3	0.3	1.0	-0.3	-0.3	-0.2	-0.1	0.9	0.9	-0.0	-1.0	0.1
Time to tail flick, test, after self-admin	0.8	0.9	2.1	-0.8	-0.8	-1.0	-0.8	1.3	1.5	0.9	0.1	0.5
Delta time to tail flick, vehicle, before/after SA	1.2	1.3	3.1	1.5	1.5	0.7	1.1	-0.9	-0.8	-0.5	0.7	-1.8
Delta time to tail flick, test, before/after SA	1.9	2.3	3.4	-1.4	-1.4	-1.8	-1.8	1.7	1.7	1.8	1.2	0.4
Tibia length	0.7	2.0	4.0	1.3	1.3	1.6	1.3	-1.1	-1.1	-1.8	-2.0	0.6
Ambulatory time before self-admin	0.0	0.1	0.2	-0.1	-0.1	0.1	-0.2	0.4	0.2	-0.0	0.5	0.2
Ambulatory time after self-admin	0.1	0.1	0.6	0.4	0.4	-0.0	-0.3	-0.1	-0.3	0.1	0.8	0.1
Bone: tissue strength	0.6	0.6	1.7	0.6	0.6	0.8	0.5	-0.5	-0.5	-0.9	-1.3	0.8
Total heroin consumption	4.5	5.3	8.5	-2.2	-2.2	-2.4	-2.7	2.9	2.8	2.4	1.3	1.0
Bone: trabecular number	1.6	3.0	5.3	-1.7	-1.7	-2.2	-1.7	1.6	1.7	2.3	1.8	-0.2
Bone: trabecular spacing	0.7	1.1	2.9	0.4	0.4	1.2	0.4	-0.8	-0.8	-1.4	-1.7	1.3
Bone: trabecular thickness	0.4	0.5	1.9	0.2	0.2	-0.5	0.0	0.1	0.1	0.7	1.3	-1.4
Bone: trabecular tissue density	0.1	0.2	1.1	-0.3	-0.3	-0.4	-0.3	0.2	0.2	0.5	1.1	-0.4
Water consumed over 24 hours	0.1	0.2	1.2	-0.0	-0.0	0.1	0.4	-0.2	-0.3	0.1	0.8	-1.1
Number of responses in last shaping day	0.7	0.9	1.4	-1.0	-1.0	-1.1	-1.2	1.1	1.0	1.1	0.6	0.1