Hub : Genes

Ndufc2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Ndufc2	0.1	0.06	3.4e-09	0.08	0.09	0.09	0.08	1.1e-07	1.5e-08	2.8e-08	9.3e-08
2	Brain	mRNA stability	Ndufc2	0.16	0.1	2.5e-11	0.12	0.09	0.09	0.1	5.4e-11	4.7e-09	1.9e-08	1.8e-09
3	RMTg	mRNA stability	Ndufc2	0.15	0.09	3.1e-03	0.12	0.13	0.12	0.11	3.6e-04	3.1e-04	5.1e-04	5.9e-04
4	Adipose	gene expression	Ndufc2	0.44	0.14	1.1e-14	0.07	0.09	0.1	0.06	7.5e-08	1.8e-10	1.1e-10	9.2e-08
5	PL	intron excision ratio	chr1_151712205_151717265	0.07	0.05	1.0e-03	0.04	0.02	0.02	0.02	9.4e-05	4.0e-03	3.3e-03	1.1e-03
6	PL	intron excision ratio	chr1_151717408_151718013	0.06	0.04	1.9e-03	0.03	0.02	0.01	0.02	2.5e-04	3.6e-03	8.8e-03	1.5e-03
7	OFC	mRNA stability	Ndufc2	0.16	0.1	2.5e-03	0.11	0.09	0.03	0.07	1.6e-03	4.6e-03	5.4e-02	8.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bone: apparent density	0.1	0.2	0.7	0.1	-0.3	0.4	0.2	-0.5	0.6	-0.8
Area under the delay curve	0.4	0.5	1.2	-0.9	-1.1	0.9	0.6	0.1	-0.1	-0.2
BMI with tail	1.2	3.8	5.6	1.4	2.1	-2.4	-1.8	2.3	-2.2	1.3
BMI without tail	6.7	13.8	19.3	2.3	4.2	-4.4	-3.8	3.9	-3.7	3.2
Body weight	3.0	12.5	18.5	2.0	3.6	-4.1	-3.1	4.3	-4.2	2.8
Weight adjusted by age	0.5	0.6	2.0	-0.5	0.8	-0.6	-0.0	0.6	-0.6	1.4
Bone surface	0.7	1.3	3.2	-1.8	-1.2	1.2	1.5	-0.5	0.6	0.2
Bone volume	0.3	0.5	1.7	-1.3	-0.7	0.6	0.7	0.1	0.0	0.4
Breakpoint value in progressive ratio session	0.4	0.4	0.5	-0.4	-0.7	0.7	0.7	-0.6	0.7	-0.6
Number of licking bursts	1.3	1.5	3.8	1.9	1.6	-1.5	-1.2	0.6	-0.6	-0.3
Context. condit. distance diff. score	3.2	3.9	6.5	-2.4	-2.2	2.3	2.5	-1.6	1.5	-0.4
Locomotion velocity, session 1	1.3	1.4	2.2	-0.9	-1.4	1.5	0.8	-1.3	1.3	-0.8
Locomotion distance, session 1	0.5	0.7	1.0	-0.9	-1.0	1.0	0.9	-0.8	0.8	-0.0
Locomotion velocity, session 2	0.3	0.3	0.9	-1.0	-0.7	0.7	0.2	-0.2	0.3	0.3
Locomotion distance, session 2	0.2	0.2	0.6	0.2	0.1	-0.3	-0.8	0.7	-0.7	0.3
Locomotion velocity, session 3	0.2	0.3	0.4	-0.6	-0.6	0.6	0.5	-0.4	0.3	-0.2
Locomotion distance, session 3	2.2	2.4	3.6	-1.8	-1.9	1.9	1.8	-1.2	1.2	-0.6
Stereotopy head waving bouts, day 3	1.7	2.0	4.5	2.1	2.1	-1.7	-1.6	0.2	-0.1	-0.1
Stereotopy head waving duration, day 3	0.3	0.4	0.9	0.8	0.3	-0.4	-0.9	0.6	-0.6	-0.5
Locomotion velocity, session 7	0.3	0.4	0.6	-0.7	-0.7	0.7	0.8	-0.4	0.5	-0.2
Locomotion distance, session 7	0.5	0.7	1.7	-1.3	-0.8	0.7	1.3	-0.1	0.2	0.6
Stereotopy head waving bouts, day 7	0.5	0.6	1.3	-0.2	-0.4	0.7	0.5	-1.1	1.1	-0.7
Stereotopy head waving duration, day 7	0.1	0.1	0.2	-0.5	-0.4	0.5	0.2	-0.3	0.3	-0.2
Locomotion velocity, session 8	4.4	5.3	9.8	-3.0	-3.1	2.9	2.4	-1.2	1.2	-1.0
Locomotion distance, session 8	1.0	1.5	2.9	-1.7	-1.6	1.5	1.3	-0.7	0.7	-0.2
Degree of sensitization distance	1.6	1.7	2.9	0.5	1.4	-1.5	-0.8	1.3	-1.3	1.7
Degree of sensitization stereotypy	2.5	2.7	3.8	-1.6	-1.7	1.9	1.8	-1.7	1.7	-0.8
Conditioned locomotion	0.1	0.1	0.3	0.2	-0.5	0.2	-0.3	0.3	-0.3	-0.6
Cocaine response after cond. corrected	0.2	0.2	1.0	-0.5	-0.2	0.1	1.0	-0.2	0.2	0.6
Cocaine response after cond. not corrected	0.6	0.7	2.2	-0.5	-0.5	0.6	1.5	-0.9	0.9	0.0
Cocaine response before conditioning	0.8	0.9	2.2	0.4	-0.1	0.6	0.5	-1.5	1.5	-1.1
Saline control response	1.3	1.7	4.0	-0.4	0.2	-0.7	-1.0	2.0	-2.0	1.4
Bone: connectivity density	1.3	2.1	3.2	-0.9	-1.2	1.6	1.5	-1.7	1.8	-1.2
Bone: cortical apparent density	0.4	0.6	1.2	0.7	0.6	-0.7	-1.1	0.8	-0.9	0.1
Bone: cortical area	0.3	0.4	1.2	-0.8	0.1	-0.2	0.6	0.7	-0.6	1.1
Bone: cortical porosity	0.2	0.2	0.5	0.1	-0.2	0.4	0.4	-0.7	0.7	-0.5
Bone: cortical porosity	0.3	0.4	1.0	0.2	-0.1	0.4	0.4	-0.9	1.0	-0.5
Bone: cortical thickness	0.0	0.1	0.2	0.2	0.4	-0.3	0.2	0.1	-0.0	0.2
Bone: cortical thickness	1.3	1.5	3.9	-1.5	-1.0	1.1	2.0	-0.9	1.0	0.5
Bone: cortical tissue density	0.4	0.5	1.3	0.8	0.6	-0.7	-1.2	0.7	-0.8	0.1
Condit. Reinf. active minus inactive responses	1.5	1.7	2.6	0.2	1.1	-1.3	-1.1	1.6	-1.6	1.6
Condit. Reinf. active-inactive response ratio	1.5	1.6	2.7	0.3	1.0	-1.3	-1.0	1.6	-1.6	1.4
Condit. Reinf. active responses	1.0	1.3	1.6	0.5	1.1	-1.2	-1.3	1.2	-1.3	1.1
Condit. Reinf. inactive responses	0.0	0.0	0.2	0.1	0.3	-0.1	-0.4	-0.0	0.0	0.0
Incentive salience index mean	0.6	0.7	1.9	-0.4	0.5	-0.6	-0.5	1.0	-1.0	1.4
Condit. Reinf. lever presses	0.2	0.3	1.0	-1.0	-0.6	0.6	0.2	-0.1	0.2	0.3
Condit. Reinf. active minus inactive responses	1.6	2.0	4.8	-2.1	-0.7	0.2	0.7	1.4	-1.4	2.2
Condit. Reinf. active-inactive response ratio	0.9	1.0	2.8	-1.7	-0.9	0.6	0.8	0.6	-0.6	1.1
Condit. Reinf. active responses	2.3	3.2	8.2	-2.3	-0.5	-0.2	0.5	2.0	-2.1	2.9
Condit. Reinf. inactive responses	1.6	2.0	4.4	-0.5	0.7	-1.1	-0.8	1.9	-1.9	2.1
Condit. Reinf. lever presses	3.3	4.5	12.7	-3.6	-2.6	1.7	1.8	1.4	-1.4	1.6
Condit. Reinf. lever reinforcers received	2.2	3.1	7.8	-2.6	-0.7	0.1	0.8	1.8	-1.8	2.8
Conditioned reinforcement - actives	5.1	5.1	8.3	-2.1	-1.9	2.4	2.9	-2.5	2.5	-0.9
Conditioned reinforcement - inactives	0.3	0.3	0.6	0.0	-0.3	0.3	0.8	-0.7	0.8	-0.7
Conditioned locomotion	4.4	5.3	8.5	-2.0	-2.1	2.4	2.9	-2.6	2.5	-1.2
Patch foraging indifference point 0 sec	0.5	0.9	1.5	-1.2	-0.8	0.2	0.4	1.2	-1.2	1.1
Patch foraging indifference point AUC	0.1	0.1	0.3	-0.4	-0.1	-0.0	0.1	0.2	-0.1	0.6
Delay disc. indifference point, 0s delay	0.2	0.3	0.6	-0.7	-0.1	0.3	0.8	-0.4	0.4	0.6
Delay disc. indifference point, 16s delay	0.4	0.4	1.6	-0.5	-1.2	0.8	0.0	0.5	-0.5	-0.4
Delay disc. indifference point, 2s delay	0.6	0.7	1.6	-1.0	-0.9	0.8	1.3	-0.5	0.5	-0.2
Delay disc. indifference point, 24s delay	0.2	0.2	0.4	0.0	-0.5	0.2	-0.4	0.6	-0.6	-0.4
Delay disc. indifference point, 4s delay	0.5	0.5	1.5	-1.2	-0.6	0.4	0.8	0.4	-0.4	0.6
Delay disc. indifference point, 8s delay	0.6	0.6	1.7	-1.1	-1.3	1.0	0.7	0.1	-0.1	-0.1
Indifference point function ln k	0.2	0.3	1.0	-0.4	-1.0	0.8	0.4	-0.1	0.1	-0.7
Indifference point function log k	0.2	0.3	1.0	-0.4	-1.0	0.8	0.4	-0.1	0.1	-0.7
Patch foraging total patch changes 0 sec	0.5	0.8	1.6	-1.3	-0.9	0.3	0.4	1.1	-1.1	0.9
Patch foraging total patch changes 12 sec	0.2	0.3	1.1	-0.8	0.1	-0.1	0.5	0.1	0.1	1.1
Patch foraging total patch changes 18 sec	0.6	0.7	2.4	-1.2	-0.2	-0.0	-0.1	0.9	-0.7	1.5
Patch foraging total patch changes 24 sec	0.3	0.4	1.8	-0.9	0.1	-0.1	0.0	0.2	-0.1	1.3
Patch foraging total patch changes 6 sec	0.1	0.2	0.6	-0.0	-0.4	-0.1	-0.1	0.8	-0.7	-0.1
Patch foraging time to switch 0 sec	1.0	1.5	4.4	2.1	1.4	-0.9	-0.8	-0.9	1.0	-1.0
Patch foraging water rate 0 sec	0.8	1.3	3.8	-2.0	-1.5	1.2	1.2	0.2	-0.3	0.6
Patch foraging water rate 12 sec	0.6	0.8	1.9	-1.4	-1.4	0.9	0.3	0.7	-0.8	0.2
Patch foraging water rate 18 sec	0.7	0.9	2.1	-1.0	-0.8	0.2	-0.0	1.3	-1.4	0.9
Patch foraging water rate 24 sec	0.8	1.1	3.6	-1.2	-1.9	1.4	0.8	0.1	-0.1	-0.6
Patch foraging water rate 6 sec	0.4	0.5	1.4	-0.9	-1.2	1.1	0.3	-0.1	-0.0	-0.4
Seeking ratio, delayed vs. immediate footshock	0.3	0.3	0.7	-0.1	-0.2	0.3	0.8	-0.8	0.8	-0.2
Distance traveled before self-admin	0.1	0.1	0.1	0.3	0.3	-0.3	-0.4	0.1	-0.2	-0.1
Distance traveled after self-admin	0.5	0.6	1.5	1.2	0.5	-0.3	-0.9	-0.3	0.2	-1.1
Extensor digitorum longus weight	0.4	1.8	4.3	0.0	0.7	-1.2	-0.8	2.1	-2.0	1.3
Bone: elastic displacement	0.1	0.2	0.6	0.5	-0.2	0.2	0.2	-0.2	0.2	-0.8
Bone: elastic work	0.8	1.0	2.7	0.2	-0.9	1.0	0.8	-1.0	1.1	-1.7
Bone: endosteal estimation	0.4	0.9	2.8	-1.4	0.0	-0.1	0.1	0.8	-0.8	1.7
Bone: endosteal perimeter	0.6	1.3	4.3	-2.1	-0.8	0.5	0.4	0.8	-0.8	1.4
Epididymis fat weight	1.7	3.9	8.0	1.3	2.8	-2.7	-1.2	1.6	-1.5	2.0
Delta time in closed arm before/after self-admin	3.3	3.2	7.5	-0.1	0.5	-1.1	-1.9	2.7	-2.7	1.6
Delta time in open arm before/after self-admin	0.6	0.6	1.6	-1.2	-0.5	0.5	1.3	-0.4	0.6	0.5
Diff in mean of infusions in LGA sessions	1.4	1.6	3.7	1.9	1.2	-1.4	-1.6	0.8	-0.7	-0.5
Delay discount exponential model param	0.4	0.4	1.2	0.9	1.1	-0.8	-0.6	-0.1	0.1	0.2
Extinction: sum of active levers before priming	0.3	0.3	0.6	-0.4	-0.1	-0.2	-0.1	0.8	-0.8	0.7
Active lever presses in extinction session 6	1.2	1.2	2.0	-0.7	-1.1	1.1	1.4	-1.3	1.2	-0.5
Bone: final force	0.3	0.5	1.6	-0.6	-0.7	0.7	1.3	-0.4	0.6	-0.4
Bone: final moment	0.3	0.5	1.4	-0.7	-0.7	0.7	1.2	-0.4	0.5	-0.3
Food consumed during 24 hour testing period	1.1	1.3	2.2	-1.3	-1.4	1.5	0.6	-1.0	1.0	-0.9
Glucose	0.2	0.4	0.7	-0.8	-0.8	0.7	0.7	-0.1	0.1	-0.4
Heart weight	0.5	0.6	1.7	-1.3	-1.0	0.7	0.8	0.2	-0.2	0.7
Delay discount hyperbolic model param	0.5	0.5	1.2	1.0	1.1	-0.9	-0.8	-0.0	0.0	0.0
Intermittent access intake day 1-15 change	2.0	2.0	3.4	-1.5	-1.8	1.7	1.8	-1.0	1.1	-0.5
Intermittent access intake escalation	2.1	2.0	3.4	-1.7	-1.9	1.7	1.8	-0.9	0.9	-0.3
Intermittent access intake escalation 2	0.6	0.6	1.3	-0.8	-0.5	0.6	1.2	-0.8	0.8	-0.0
Intermitt. access day 1 inactive lever presses	0.4	0.5	1.2	0.6	0.5	-0.2	0.4	-1.1	1.1	-0.3
Intermitt. access day 15 inactive lever presses	0.1	0.1	0.3	0.0	-0.3	0.2	0.5	-0.2	0.2	-0.3
Intermitt. access escalation Index	0.2	0.2	0.6	0.6	0.2	-0.2	-0.3	-0.0	0.0	-0.7
Intermittent access day 1 total infusions	0.5	0.6	1.6	-1.3	-0.8	0.8	1.1	-0.2	0.2	0.1
Intermittent access day 15 total infusions	3.1	3.5	6.5	-2.2	-2.2	2.1	2.5	-1.3	1.3	-0.7
Intermittent access terminal intake (last 3 days)	1.9	2.0	4.5	-1.7	-1.3	1.4	2.1	-1.2	1.2	-0.5
Intermittent access total infusions	1.6	1.8	4.1	-1.5	-1.0	1.3	2.0	-1.3	1.3	-0.4
Intermittent access day 1 locomotion	1.8	1.8	3.1	-0.7	-0.8	1.2	1.7	-1.7	1.7	-1.2
Intermittent access day 15 total locomotion	1.2	1.3	2.8	-1.5	-1.1	1.2	1.7	-0.9	0.9	-0.2
Intermittent access total locomotion	0.9	1.0	2.4	-1.1	-0.6	0.9	1.5	-1.1	1.0	-0.4
Intermittent access standard deviation	0.3	0.3	0.8	-0.3	-0.1	0.2	0.9	-0.7	0.7	0.0
Left kidney weight	1.1	3.1	5.6	-0.2	1.5	-1.7	-1.5	2.1	-2.1	2.4
Right kidney weight	1.1	3.0	4.3	0.3	1.5	-1.7	-1.7	2.1	-2.0	2.0
Cocaine induced anxiety	0.8	0.9	2.0	1.4	1.1	-0.8	-1.4	0.3	-0.3	-0.5
Post-drug Anxiety	0.3	0.4	1.0	0.4	0.3	-0.5	-1.0	0.7	-0.7	0.3
Baseline Anxiety	1.1	1.2	3.0	-1.7	-1.5	1.1	1.1	0.2	-0.2	0.8
Tail length	3.5	10.6	16.3	0.7	3.2	-3.5	-2.9	3.8	-3.6	4.0
Length with tail	2.5	9.1	13.1	1.3	3.0	-3.4	-2.8	3.6	-3.6	2.9
Length without tail	0.1	0.3	0.6	0.6	-0.1	-0.2	-0.2	0.5	-0.7	-0.7
Times rat made contact with spout	0.9	1.1	2.1	1.1	1.4	-1.2	-1.4	0.7	-0.7	0.2
Lifetime Intake	1.6	1.8	3.7	-1.6	-1.1	1.4	1.9	-1.3	1.2	-0.2
Liver weight, left	0.8	1.2	2.0	0.9	1.3	-1.4	-0.8	1.3	-1.2	0.5
Liver weight, right	3.3	5.5	12.1	2.5	3.5	-3.2	-2.0	1.5	-1.5	0.9
Locomotor activity	1.5	2.5	6.3	1.0	1.1	-1.3	-2.5	1.8	-1.6	1.1
Locomotor testing distance	1.7	2.8	5.5	-0.2	0.9	-1.2	-1.9	2.0	-1.9	2.4
Locomotor testing rearing	3.0	4.6	6.6	0.7	2.1	-2.2	-2.3	2.3	-2.2	2.6
Locomotion in novel chamber	2.1	2.6	3.4	-1.1	-1.3	1.8	1.5	-1.9	1.9	-1.7
Locomotion in novel chamber post-restriction	3.5	4.2	6.6	-2.1	-2.5	2.6	2.3	-1.5	1.5	-1.5
Fecal boli incidents, locomotor time 1	3.5	3.8	5.9	-2.2	-1.9	2.1	2.4	-1.9	1.9	0.3
Change in fecal boli incidents, locomotor task	2.0	1.9	4.1	1.8	1.1	-1.2	-2.0	1.0	-1.2	-0.7
Time >=10cm from walls, locomotor time 1	1.2	1.2	1.8	-1.0	-1.3	1.4	1.3	-0.9	0.8	-0.6
Bouts of movement, locomotor time 1	0.4	0.5	1.3	-0.5	-0.7	0.3	-0.3	1.0	-1.1	0.1
Total resting periods, locomotor time 1	0.3	0.4	1.0	-0.5	-1.0	0.6	0.0	0.6	-0.7	-0.5
Rest time, locomotor task time 1	0.4	0.4	1.4	-0.6	-1.2	0.9	0.3	-0.1	-0.1	-0.6
Distance moved, locomotor task time 1	0.5	0.6	2.0	-0.2	0.9	-0.8	-0.1	0.6	-0.5	1.4
Vertical activity count, locomotor time 1	0.3	0.3	0.8	-0.1	0.6	-0.6	0.1	0.6	-0.4	0.9
Time >=10cm from walls, locomotor time 2	0.4	0.4	1.2	-1.1	-0.5	0.5	1.0	-0.1	0.2	0.6
Bouts of movement, locomotor time 2	0.1	0.1	0.3	-0.0	0.3	-0.3	-0.2	0.6	-0.5	0.2
Total resting periods, locomotor time 2	0.0	0.1	0.1	-0.0	0.2	-0.2	-0.2	0.4	-0.3	0.2
Rest time, locomotor task time 2	0.5	0.6	1.3	1.1	0.6	-0.2	-0.7	-0.8	0.7	-0.9
Distance moved, locomotor task time 2	0.8	1.0	2.6	-1.6	-0.3	0.2	1.4	0.0	-0.0	1.4
Vertical activity count, locomotor time 2	0.6	0.7	2.4	-1.1	0.1	-0.3	0.8	0.6	-0.4	1.5
Light reinforcement 1	0.7	1.3	2.9	1.7	1.6	-1.5	-1.0	0.4	-0.4	0.3
Light reinforcement 2	0.2	0.2	0.5	0.4	0.2	0.0	0.4	-0.7	0.6	-0.5
Bone: marrow area	0.4	0.8	2.5	-1.2	0.1	-0.2	0.0	0.8	-0.8	1.6
Bone: maximum diameter	0.5	1.0	2.8	-1.7	-0.7	0.3	0.9	0.8	-0.8	1.1
Bone: maximum force	0.6	1.0	1.9	-1.0	-1.1	1.2	1.4	-0.6	0.8	-0.7
Bone: maximum moment	0.5	0.9	1.8	-1.1	-1.1	1.1	1.3	-0.6	0.8	-0.6
Mean time between licks in bursts	0.8	1.2	4.8	-1.4	0.4	-0.4	0.2	0.7	-0.7	2.2
Mean num. licks in bursts	0.8	0.9	2.8	-1.7	-1.2	1.1	0.8	-0.3	0.3	0.3
Cd content in liver	0.4	0.4	0.7	0.6	0.8	-0.8	-0.6	0.5	-0.5	0.5
Co content in liver	0.5	0.6	1.9	-1.3	-0.2	0.1	-0.1	0.6	-0.6	1.4
Cu content in liver	1.6	1.9	3.8	-0.3	0.8	-1.1	-1.2	1.7	-1.7	2.0
Fe content in liver	0.6	0.7	1.9	-1.0	-0.5	0.7	1.4	-0.8	0.8	0.3
K content in liver	0.6	0.6	1.4	1.0	1.0	-0.8	-1.2	0.2	-0.2	-0.0
Mg content in liver	0.0	0.0	0.1	-0.1	0.1	-0.1	-0.2	0.2	-0.2	0.2
Mn content in liver	0.8	1.0	2.3	0.7	-0.2	0.5	0.5	-1.3	1.3	-1.5
Na content in liver	1.2	1.2	3.0	0.2	-0.2	0.7	1.1	-1.7	1.7	-1.0
Rb content in liver	0.7	0.8	2.2	-0.6	-0.2	-0.3	-0.6	1.5	-1.5	0.9
Se content in liver	0.8	1.0	2.2	1.5	0.8	-0.3	-0.4	-1.1	1.1	-1.0
Sr content in liver	0.7	0.7	1.0	-0.9	-1.0	1.0	0.9	-0.7	0.7	-0.4
Zn content in liver	0.6	0.6	1.9	-1.2	-0.3	0.1	0.2	0.7	-0.7	1.4
Bone: minimum diameter	0.8	1.4	4.0	-0.6	0.9	-1.0	-0.7	1.3	-1.3	2.0
Time in familiar zone, hab. session 1	0.1	0.1	0.1	-0.2	-0.2	0.2	0.3	-0.2	0.3	-0.1
Time in novel zone, hab. session 1	1.0	1.0	1.7	0.7	0.8	-1.1	-1.0	1.2	-1.3	0.8
Total zone transitions, hab. session 1	0.3	0.4	1.6	0.8	-0.3	0.2	-0.5	0.0	-0.0	-1.3
Total locomotion distance, hab. session 1	3.9	5.5	11.4	2.9	3.4	-3.0	-2.3	1.1	-1.1	1.1
Locomotion velocity, hab. session 1	3.0	4.3	9.6	2.7	3.1	-2.7	-1.9	0.7	-0.7	0.9
Time in familiar zone, hab. session 2	0.3	0.3	0.7	-0.7	-0.2	-0.0	-0.3	0.8	-0.8	0.5
Time in novel zone, hab. session 2	0.3	0.3	0.9	-0.3	-0.3	0.4	0.9	-0.7	0.7	0.0
Total zone transitions, hab. session 2	0.1	0.2	0.4	0.3	-0.5	0.2	-0.1	0.4	-0.4	-0.7
Total locomotion distance, hab. session 2	3.4	4.4	7.7	2.2	2.8	-2.7	-2.1	1.6	-1.6	1.5
Locomotion velocity, hab. session 2	4.0	5.4	8.5	2.4	2.9	-2.9	-2.3	1.9	-1.9	1.6
Novel to familiar place preference ratio	0.0	0.0	0.1	0.3	0.0	-0.1	0.2	0.1	-0.1	-0.2
Novelty place preference	0.0	0.0	0.1	0.1	-0.1	-0.1	0.2	0.2	-0.2	-0.0
Time in novel zone, NPP test	0.1	0.1	0.1	-0.1	-0.3	0.1	0.3	0.3	-0.3	-0.0
Total zone transitions, NPP test	0.4	0.5	1.3	-0.5	-1.1	1.0	0.5	-0.4	0.4	-0.8
Total locomotion distance, NPP test	1.4	1.9	5.2	1.5	2.3	-1.9	-0.9	0.2	-0.3	1.3
Locomotion velocity, NPP test	1.7	2.4	6.5	1.8	2.6	-2.1	-1.0	0.2	-0.2	1.3
Intraocular pressure	3.3	4.6	9.0	-2.7	-3.0	2.7	2.5	-1.0	1.0	-0.8
Delta distance traveled before/after self-admin	0.3	0.3	0.8	0.9	0.3	-0.3	-0.8	0.2	-0.2	-0.6
Delta ambulatory time before/after self-admin	0.3	0.3	1.1	0.7	-0.3	0.1	-0.5	0.1	-0.1	-1.0
Parametrial fat weight	1.7	3.3	5.2	1.9	2.2	-2.3	-1.7	1.8	-1.7	0.8
Pavlov. Cond. lever latency	0.3	0.4	1.4	1.2	0.6	-0.7	-0.5	0.3	-0.3	-0.4
Pavlov. Cond. magazine entry latency	0.4	0.5	1.5	-1.2	-0.2	0.2	0.5	0.5	-0.5	1.1
Pavlov. Cond. change in total contacts	1.1	1.2	2.5	-1.6	-0.7	0.9	1.6	-0.9	1.0	0.6
Pavlov. Cond. index score	0.5	0.7	2.3	-1.5	-0.3	0.3	0.3	0.4	-0.3	1.3
Pavlov. Cond. latency score	0.4	0.6	2.1	-1.5	-0.4	0.4	0.5	0.2	-0.1	1.1
Pavlov. Cond. lever contacts	0.3	0.3	1.4	-1.2	-0.3	0.4	0.2	0.0	0.0	0.9
Pavlov. Cond. magazine entry number	0.5	0.7	2.1	1.4	0.5	-0.3	-0.4	-0.6	0.6	-1.2
Pavlov. Cond. intertrial magazine entries	0.4	0.5	1.0	1.0	0.9	-0.7	-0.9	-0.2	0.2	-0.2
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	2.1	-1.4	-0.4	0.4	0.4	0.1	-0.1	1.0
Pavlov. Cond. response bias	0.2	0.3	1.1	-0.8	0.0	0.0	-0.2	0.3	-0.3	1.0
Pavlov. Cond. lever latency	4.6	6.1	17.2	4.1	3.2	-2.2	-2.0	-1.3	1.4	-1.7
Pavlov. Cond. magazine entry latency	2.7	3.1	6.9	-2.6	-2.6	2.1	1.9	-0.0	0.0	0.1
Pavlov. Cond. change in total contacts	2.8	3.8	10.5	-3.2	-2.4	1.6	1.7	1.1	-1.1	1.4
Pavlov. Cond. index score	4.2	5.3	14.9	-3.9	-3.1	2.3	2.2	0.8	-0.8	1.2
Pavlov. Cond. latency score	4.0	5.0	13.5	-3.7	-3.1	2.3	2.1	0.6	-0.7	1.0
Pavlov. Cond. lever contacts	4.1	5.5	15.0	-3.9	-2.9	1.9	1.8	1.6	-1.6	1.8
Pavlov. Cond. magazine entry number	5.6	6.8	17.0	4.1	3.6	-3.0	-2.9	0.2	-0.2	-0.5
Pavlov. Cond. intertrial magazine entries	3.0	3.9	6.4	1.4	2.5	-2.3	-2.3	1.4	-1.5	1.9
Pavlov. Cond. lever-magazine prob. diff.	3.9	5.0	14.0	-3.7	-2.9	2.1	2.2	0.8	-0.8	1.3
Pavlov. Cond. response bias	4.8	6.6	18.8	-4.3	-3.3	2.4	2.4	1.0	-1.0	1.7
Time in closed arm before self-admin	0.9	1.0	1.3	-0.3	-1.1	1.1	1.0	-1.1	1.1	-1.0
Time in closed arm after self-admin	1.0	1.1	2.1	-0.6	-1.5	1.4	0.6	-0.7	0.8	-1.1
Time in open arm before self-admin	1.0	1.0	2.1	1.2	1.1	-1.1	-1.4	0.6	-0.9	0.3
Time in open arm after self-admin	0.6	0.7	1.3	0.3	1.1	-1.1	-0.6	0.7	-0.7	0.9
Bone: periosteal estimation	0.5	1.1	3.3	-1.8	-0.3	0.2	0.9	0.6	-0.6	1.7
Bone: periosteal perimeter	0.7	1.2	2.4	-1.2	-0.3	-0.2	-0.5	1.6	-1.5	1.3
Bone: post-yield work	0.2	0.2	0.6	-0.1	-0.3	0.5	0.1	-0.5	0.6	-0.8
Progressive ratio test 1 active lever presses	0.3	0.3	0.6	0.1	-0.1	0.3	0.4	-0.8	0.7	-0.7
Progressive ratio test 1 breakpoint	0.4	0.4	1.0	0.1	0.0	0.4	0.4	-1.0	1.0	-0.8
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.2	-0.3	-0.1	0.2	0.4	-0.4	0.4	0.0
Progressive ratio test 2 active lever presses	1.1	1.2	3.2	-1.8	-0.8	0.8	1.8	-0.4	0.5	0.5
Progressive ratio test 2 breakpoint	0.8	0.9	2.5	-1.5	-0.6	0.6	1.6	-0.4	0.4	0.5
Progressive ratio test 2 inactive lever presses	0.5	0.6	1.5	-1.2	-0.6	0.7	1.2	-0.5	0.5	0.1
Incentive Sensitization - Responses	1.1	1.1	3.1	-1.8	-0.8	0.6	1.7	0.1	-0.0	0.9
Incentive Sensitization - Breakpoint	1.1	1.1	3.2	-1.7	-0.8	0.6	1.8	-0.1	0.1	0.8
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.5	0.7	0.5	-0.7	-0.4	0.5	-0.4	0.0
Progressive ratio	0.8	1.0	2.4	-1.2	-1.5	1.4	0.7	-0.4	0.3	-0.3
Food seeking constrained by brief footshock	1.4	1.7	3.8	-0.2	0.6	-0.9	-1.2	1.7	-1.6	1.9
Seeking ratio, punishment vs. effort	1.5	1.8	3.7	0.9	1.9	-1.9	-0.9	1.0	-0.9	1.6
Retroperitoneal fat weight	5.9	19.4	30.4	3.4	5.3	-5.5	-4.1	4.3	-4.4	3.3
Reaction time number correct	0.2	0.3	0.9	1.0	0.0	-0.0	-0.9	-0.0	0.2	-0.6
Reaction time mean minus median	0.6	0.8	1.9	-0.2	0.4	-0.6	-1.0	1.3	-1.4	0.9
Reaction time mean minus median AUC	0.2	0.3	0.8	-0.2	0.0	-0.2	-0.7	0.8	-0.9	0.4
Reaction time num false alarms	0.4	0.6	1.0	0.9	1.0	-1.0	-0.9	0.5	-0.5	0.4
Reaction time num false alarms AUC	0.0	0.1	0.1	0.3	0.3	-0.2	-0.3	-0.2	0.2	-0.0
Reaction time trials correct on left	0.2	0.3	0.9	1.0	0.0	-0.0	-0.9	-0.0	0.2	-0.6
Reaction time trials on left	0.2	0.3	0.9	0.9	0.0	-0.0	-0.9	-0.1	0.2	-0.6
Reaction time mean	0.3	0.3	0.6	0.6	0.7	-0.8	-0.4	0.5	-0.5	0.5
Reaction time mean AUC	0.1	0.1	0.3	0.6	0.4	-0.5	-0.1	0.3	-0.3	0.2
Median of all reaction times	0.1	0.1	0.4	0.6	0.5	-0.4	0.2	-0.1	0.2	0.2
Reaction time omissions	0.4	0.5	1.2	-0.1	0.2	-0.5	-0.1	1.1	-1.0	1.1
Reaction time false alarm rate	0.1	0.1	0.3	-0.1	0.2	-0.1	0.5	-0.4	0.3	0.2
Reaction time premature initiation rate	2.4	3.2	5.0	0.4	1.8	-2.0	-1.2	2.0	-2.1	2.2
Reaction time premature initiations	1.5	2.2	2.9	0.6	1.5	-1.7	-1.3	1.6	-1.7	1.7
Std. dev. reaction times	1.0	1.5	2.6	0.0	0.8	-1.1	-1.1	1.6	-1.6	1.5
Reaction time trials completed	0.2	0.3	0.9	0.9	0.0	-0.0	-0.9	-0.1	0.2	-0.6
Reaction time trials AUC	0.2	0.3	1.0	1.0	0.2	-0.2	-1.0	0.2	-0.1	-0.4
Run reversals in cocaine runway, females	4.3	4.1	6.5	0.2	1.6	-1.9	-1.9	2.6	-2.6	2.5
Run reversals in cocaine runway, males	1.2	1.1	3.3	-1.2	-1.8	1.3	1.1	0.1	0.0	-0.6
Latency to leave start box in cocaine runway	0.7	0.7	1.9	1.2	1.4	-0.9	-0.8	-0.5	0.4	0.1
Latency to leave start box in cocaine runway, F	0.6	0.7	2.1	0.7	1.4	-0.9	-0.5	-0.4	0.4	0.8
Latency to leave start box in cocaine runway, M	0.5	0.5	1.3	0.9	0.1	0.1	-0.0	-0.8	0.8	-1.1
Std. dev. time between licks in bursts	1.9	2.3	3.5	0.5	1.7	-1.6	-1.7	1.4	-1.4	1.9
Total sessions with >9 infusions	1.2	1.3	2.2	-1.2	-1.0	1.3	1.5	-1.2	1.2	-0.2
Short access day 1 total inactive lever presses	0.3	0.4	0.9	-0.7	-0.7	0.6	1.0	-0.3	0.4	-0.2
Short access day 10 total inactive lever presses	0.6	0.7	2.0	1.4	0.9	-1.0	-0.7	0.5	-0.4	-0.3
Short access day 1 total infusions	0.9	0.9	2.0	-1.4	-0.7	0.9	1.3	-0.8	0.8	0.4
Short access day 10 total infusions	0.9	1.0	2.3	-1.5	-0.7	1.0	1.3	-0.9	0.9	0.4
Short access total infusions	0.7	0.8	1.4	-1.1	-0.5	0.8	1.2	-1.0	1.0	0.2
Short access day 1 locomotion	2.8	3.1	4.7	-1.7	-2.2	2.1	2.1	-1.5	1.4	-0.8
Short access day 10 total locomotion	0.1	0.1	0.2	-0.4	-0.1	0.3	0.4	-0.5	0.3	0.0
Short access total locomotion	0.9	0.9	2.6	-0.2	-0.1	0.6	0.8	-1.6	1.6	-0.6
One hour access (0.3 mA shock)	1.0	1.1	3.2	-1.8	-0.9	0.8	1.5	-0.3	0.3	0.9
Compulsive drug intake	0.0	0.0	0.2	0.1	0.1	0.0	0.1	-0.4	0.4	0.0
One hour access (shock baseline)	0.6	0.7	1.9	-1.4	-1.0	0.8	1.2	-0.3	0.3	0.3
Social response proportion	1.2	1.3	2.9	1.7	1.7	-1.4	-1.3	-0.0	-0.2	-0.1
Social responses	2.6	3.3	4.5	1.6	2.0	-2.1	-2.1	1.6	-1.9	1.1
Social time	0.7	0.9	2.8	1.7	1.2	-1.0	-0.9	-0.1	0.0	-0.2
Soleus weight	1.2	3.6	4.8	0.9	2.0	-2.1	-2.0	2.2	-2.1	1.7
Bone: stiffness	0.1	0.2	0.5	-0.1	-0.3	0.3	0.7	-0.2	0.3	-0.6
Tibialis anterior weight	0.3	1.0	2.0	0.6	0.8	-1.1	-0.7	1.4	-1.3	0.8
Time to tail flick, vehicle, before self-admin	0.7	0.8	1.2	0.9	0.9	-1.0	-1.1	0.9	-0.7	0.5
Time to tail flick, vehicle, after self-admin	0.7	0.7	1.6	-1.3	-1.3	1.1	0.6	0.1	-0.2	0.1
Time to tail flick, test, before self-admin	0.3	0.3	0.8	-0.9	-0.7	0.5	0.5	0.3	-0.1	0.4
Time to tail flick, test, after self-admin	0.7	0.7	2.2	-1.0	-0.3	0.0	-0.1	1.1	-0.8	1.5
Delta time to tail flick, vehicle, before/after SA	2.4	2.4	4.4	-1.8	-2.1	2.0	1.8	-1.0	0.8	-0.6
Delta time to tail flick, test, before/after SA	0.1	0.1	0.3	0.5	0.3	-0.3	-0.5	0.3	-0.2	0.2
Tibia length	0.6	1.8	2.6	-1.5	-1.5	1.6	1.6	-1.1	1.3	-0.3
Ambulatory time before self-admin	0.1	0.2	0.3	-0.1	-0.4	0.4	0.4	-0.4	0.3	-0.6
Ambulatory time after self-admin	0.6	0.6	2.8	0.9	-0.2	0.3	-0.2	-0.6	0.6	-1.7
Bone: tissue strength	1.8	1.7	5.6	1.0	-0.3	0.6	0.8	-1.5	1.5	-2.4
Total heroin consumption	0.1	0.1	0.3	-0.1	-0.5	0.1	0.2	0.3	-0.3	-0.2
Bone: trabecular number	0.4	0.6	1.9	0.3	-0.4	0.6	0.3	-0.9	0.9	-1.4
Bone: trabecular spacing	0.2	0.3	0.6	-0.8	-0.5	0.5	0.5	-0.4	0.3	0.6
Bone: trabecular thickness	1.1	1.3	3.1	0.3	0.4	-0.9	-1.3	1.8	-1.8	0.5
Bone: trabecular tissue density	3.3	4.6	6.4	2.1	2.2	-2.4	-2.5	2.2	-2.3	0.9
Water consumed over 24 hours	0.6	0.8	1.9	1.4	0.9	-0.7	-1.3	0.1	-0.1	-0.8
Number of responses in last shaping day	0.5	0.5	1.7	0.0	1.1	-0.8	-0.1	-0.1	0.1	1.3